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G PROTEIN
STRUCTURE
RECEPTOR
OTHER PROTEINS
STRUCTURE LIGAND
ENDOGENOUS LIGAND
REFERENCE
Fam. α Species Note % of Seq β Species γ Species Method
PDB
Refined
structure
Resolution
UniProt
IUPHAR Receptor family Class Species Receptor fusion Antibodies Other Name Type Function Name Type Last author Reference PDB Date
Gi/o αo Human - 59 β1 Human γ2 Human cryo-EM 6G79 - 3.8 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human - - - Donitriptan pubchem
small molecule Agonist 5-hydroxytryptamine,... small molecule Tate CG 10.1038/S41586-018-0241-9 2018-06-20 180
Gi/o αi1 Human Non-canonical confor... 62 β1 Human γ2 Human cryo-EM 6OSA - 3.0 NTR1 NTS1 Neurotensin A (Rhodopsin) Human - - - JMV449 pubchem
peptide Agonist neurotensin, large n... peptide Skiniotis G 10.1038/S41586-019-1337-6 2019-07-10 131
Gs αs Bovine - 56 β1 Rat γ2 Bovine cryo-EM 6NBI 6NBI_refined 4.0 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human - Nanobody-35 - Long-acting parathyr...
peptide Agonist PTHrP, TIP39, PTH, P... protein Zhang Y 10.1126/SCIENCE.AAV7942 2019-04-17 107
Gi/o αo Human - 60 β1 Mouse γ2 Human cryo-EM 6K41 - 2.9 ADA2B α2B Adrenoceptors A (Rhodopsin) Human T4-Lysozyme scFv - Dexmedetomidine pubchem
small molecule Agonist (-)-adrenaline, (-)-... small molecule Kobilka BK 10.1038/S41589-020-0492-2 2020-04-15 186
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 6PB1 6PB1_refined 2.8 CRFR2 CRF2 Corticotropin-releasing factor B1 (Secretin) Human - Nanobody-35 - Urocortin pubchem chembl_ligand
peptide Agonist urocortin 2, cortico... peptide Xu HE 10.1016/J.MOLCEL.2020.01.013 2020-02-12 29
Gi/o αo Human - 59 β1 Rat γ2 Mouse cryo-EM 6WWZ 6WWZ_refined 3.3 CCR6 CCR6 Chemokine A (Rhodopsin) Human - scFv16 - CCL20
protein Agonist CCL20, beta-defensin... protein Wu H 10.1038/S41467-020-16820-6 2020-06-24 189
Gq/11 α11 Human - 63 β1 Human γ2 Human cryo-EM 6OIJ 6OIJ_refined 3.3 ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human - Antibody fragment - Iperoxo pubchem
small molecule Agonist acetylcholine small molecule Kobilka BK 10.1126/SCIENCE.AAW5188 2019-05-08 198
Gi/o αi1 Human - 64 β1 Human γ2 Human cryo-EM 6VMS 6VMS_refined 3.8 DRD2 D2 Dopamine A (Rhodopsin) Human T4-Lysozyme scFv16 - Bromocriptine pubchem
small molecule Agonist dopamine small molecule Rosenbaum DM 10.1038/S41586-020-2379-5 2020-06-17 155
Gs αs Human Mini-Gs 61 β1 Human γ2 Human cryo-EM 6LI3 6LI3_refined 3.3 GPR52 GPR52 A orphans A (Rhodopsin) Human - Nanobody-35 - Apo (no ligand)
none Apo (no ligand) - - Xu F 10.1038/S41586-020-2019-0 2020-02-26 32
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 6PT0 - 3.2 CNR2 CB2 Cannabinoid A (Rhodopsin) Human - scFv16 - Win 55212-2 pubchem chembl_ligand
small molecule Agonist 2-arachidonoylglycer... small molecule Xie X 10.1016/J.CELL.2020.01.007 2020-02-12 143
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 6N4B 6N4B_refined 3.0 CNR1 CB1 Cannabinoid A (Rhodopsin) Human - scFv16 - Fub-mdmb pubchem
small molecule Agonist 2-arachidonoylglycer... small molecule Skiniotis G 10.1016/J.CELL.2018.11.040 2019-01-30 122
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6WPW 6WPW_refined 3.1 GLR glucagon Glucagon B1 (Secretin) Human - Nanobody-35 - Glucagon derivative ...
peptide Agonist glucagon peptide Kobilka BK 10.1126/SCIENCE.ABA3373 2020-08-12 56
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 7CFN 7CFN_refined 3.0 GPBAR GPBA Bile acid A (Rhodopsin) Human - Nanobody-35 - INT-777 pubchem
INT-777 pubchem
small molecule
small molecule
Agonist
PAM
chenodeoxycholic aci... small molecule Zhang Y 10.1038/S41586-020-2569-1 2020-09-09 83
Gs αs Human Engineered G protein 50 - - - - X-ray 5G53 5G53_refined 3.4 AA2AR A2A Adenosine A (Rhodopsin) Human - - - NECA pubchem
small molecule Agonist adenosine small molecule Tate CG 10.1038/NATURE18966 2016-08-03 1
Gs αs Human - 61 β1 Human γ2 Human cryo-EM 6WZG 6WZG_refined 2.3 SCTR secretin Glucagon B1 (Secretin) Human - Nanobody-35 - secretin
peptide Agonist secretin, VIP peptide Miller LJ 10.1038/S41467-020-17791-4 2020-08-12 62
Gq/11 αq Human Gq-Gi2 chimera 59 β1 Human γ2 Human cryo-EM 6WHA 6WHA_refined 3.4 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human BRIL scFv16 Gq 25-CN-NBOH pubchem
small molecule Agonist 5-hydroxytryptamine,... small molecule Roth BL 10.1016/J.CELL.2020.08.024 2020-09-23 201
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6P9Y 6P9Y_refined 3.0 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - PACAP pubchem
peptide Agonist VIP, PACAP-27, PACAP... peptide Wootten D 10.1016/J.MOLCEL.2020.01.012 2020-02-05 23
Gs αs Human - 61 β1 Human γ2 Human cryo-EM 6VN7 6VN7_refined 3.2 VIPR1 VPAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - PACAP pubchem
peptide Agonist secretin, GHRH, VIP,... peptide Jiang Y 10.1038/S41467-020-17933-8 2020-09-02 95
Gs αs Human - 89 β1 Human γ2 Human cryo-EM 6X19 6X19_refined 2.1 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - CHU-128 pubchem
small molecule Agonist glucagon, glucagon-l... peptide Wootten D 10.1101/2020.08.16.252585 2020-09-09 92
Gi/o αi1 Human - 65 β1 Human γ2 Human cryo-EM 6LFO 6LFO_refined 3.4 CXCR2 CXCR2 Chemokine A (Rhodopsin) Human - scFv16 - Interleukin-8 pubchem
protein Agonist CXCL6, CXCL8, CXCL1,... protein Liu Z 10.1038/S41586-020-2492-5 2020-09-02 158
Gi/o αi2 Human - 59 β1 Human γ2 Human cryo-EM 6D9H 6D9H_refined 3.6 AA1R A1 Adenosine A (Rhodopsin) Human - - - adenosine pubchem
small molecule Agonist adenosine small molecule Christopoulos A 10.1038/S41586-018-0236-6 2018-06-20 176
Gs αs Human - 43 β1 Human γ2 Human cryo-EM 6NIY 6NIY_refined 3.3 CALCR CT Calcitonin B1 (Secretin) Human - - - calcitonin
peptide Agonist calcitonin, adrenome... peptide Sexton PM 10.1021/ACSPTSCI.8B00056 2019-01-23 5
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6UUS 6UUS_refined 2.4 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP3
- adrenomedullin
peptide Agonist adrenomedullin, &alp... peptide Sexton PM 10.1021/ACSPTSCI.9B00080 2020-04-01 38
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBM 6XBM_refined 3.2 SMO SMO Frizzled F (Frizzled) Human - scFv16 - 24,25-Epoxy-choleste... pubchem
24,25-Epoxy-choleste... pubchem
small molecule
small molecule
Agonist
PAM
constitutive constitutive Li X 10.1038/S41589-020-0646-2 2020-09-30 170
Gs αs Bovine - 89 β1 Rat γ2 Bovine X-ray 3SN6 3SN6_refined 3.2 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human T4-Lysozyme Antibody - BI-167107 pubchem
small molecule Agonist (-)-adrenaline, (-)-... small molecule Kobilka BK 10.1038/NATURE10361 2011-07-20 98
Gs αs Human - 56 β1 Rat γ2 Bovine cryo-EM 7BW0 7BW0_refined 3.9 GPBAR GPBA Bile acid A (Rhodopsin) Human BRIL Nanobody-35 - - - - chenodeoxycholic aci... small molecule Ren R 10.1038/S41392-020-00262-Z 2020-09-02 77
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6B3J 6B3J_refined 3.3 GLP1R GLP-1 Glucagon B1 (Secretin) Human - - - Exendin-P5
peptide Agonist glucagon, glucagon-l... peptide Wootten D 10.1038/NATURE25773 2018-02-21 11
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6E3Y 6E3Y_refined 3.3 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP1
- Calcitonin gene-rela... pubchem
peptide Agonist adrenomedullin, &alp... peptide Sexton PM 10.1038/S41586-018-0535-Y 2018-09-19 20
Gs αs Human - 57 β1 Human γ2 Human cryo-EM 6GDG 6GDG_refined 4.1 AA2AR A2A Adenosine A (Rhodopsin) Human TrxA Nanobody - NECA pubchem
small molecule Agonist adenosine small molecule Tate CG 10.7554/ELIFE.35946 2018-05-16 14
Gs αs Bovine - 58 β1 Rat γ2 Bovine cryo-EM 6NBF 6NBF_refined 3.0 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human - Nanobody-35 - Long-acting parathyr...
peptide Agonist PTHrP, TIP39, PTH, P... protein Zhang Y 10.1126/SCIENCE.AAV7942 2019-04-17 101
Gs αs Human - 57 β1 Rat γ2 Bovine cryo-EM 6LPB 6LPB_refined 3.9 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - PACAP pubchem
peptide Agonist VIP, PACAP-27, PACAP... peptide Nureki O 10.1038/S41594-020-0386-8 2020-03-11 47
Gi/o αi1 Human - 64 β1 Human γ2 Human cryo-EM 6KPG 6KPG_refined 3.0 CNR1 CB1 Cannabinoid A (Rhodopsin) Human - scFv16 - (6Ar,9R,10aR)-9-(hyd... pubchem
small molecule Agonist 2-arachidonoylglycer... small molecule Liu Z 10.1016/J.CELL.2020.01.008 2020-02-12 137
Gs αs Human Gs-Gi1 chimera 58 β1 Human γ2 Human cryo-EM 6PB0 6PB0_refined 3.0 CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human - Nanobody-35 - Urocortin pubchem chembl_ligand
peptide Agonist urocortin 2, cortico... peptide Xu HE 10.1016/J.MOLCEL.2020.01.013 2020-02-12 26
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBK 6XBK_refined 3.2 SMO SMO Frizzled F (Frizzled) Human - scFv16 - Cholesterol pubchem
N/A Agonist constitutive constitutive Li X 10.1038/S41589-020-0646-2 2020-09-30 164
Gi/o αo Human - 61 β1 Human γ2 Human cryo-EM 6OIK 6OIK_refined 3.6 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human - - - Iperoxo pubchem
2CU pubchem
small molecule
small molecule
Agonist
PAM
acetylcholine small molecule Kobilka BK 10.1126/SCIENCE.AAW5188 2019-05-08 183
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6OMM 6OMM_refined 3.2 FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human - - - WKYMVX
peptide Agonist annexin I, humanin, ... protein Zhang C 10.1038/S41467-020-14728-9 2020-02-26 146
Gi/o αi1 Human - 62 β1 Mouse γ2 Human cryo-EM 6K42 6K42_refined 4.1 ADA2B α2B Adrenoceptors A (Rhodopsin) Human T4-Lysozyme scFv - Dexmedetomidine pubchem
small molecule Agonist (-)-adrenaline, (-)-... small molecule Kobilka BK 10.1038/S41589-020-0492-2 2020-04-15 152
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBL - 3.9 SMO SMO Frizzled F (Frizzled) Human - scFv16 - SAG pubchem
Cholesterol pubchem
small moelcule
N/A
PAM
Agonist
constitutive constitutive Li X 10.1038/S41589-020-0646-2 2020-09-30 173
Gs αs Human - 57 β1 Human γ2 Human cryo-EM 6VCB 6VCB_refined 3.3 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - Glucagon-like peptid...
LSN3160440 pubchem
peptide
small molecule
Agonist
PAM
glucagon, glucagon-l... peptide Sloop KW 10.1038/S41589-020-0589-7 2020-07-22 50
Gi/o αi1 Human - 65 β1 Human γ2 Human cryo-EM 6LFM 6LFM_refined 3.5 CXCR2 CXCR2 Chemokine A (Rhodopsin) Human - scFv16 - Interleukin-8 pubchem
protein Agonist CXCL6, CXCL8, CXCL1,... protein Liu Z 10.1038/S41586-020-2492-5 2020-09-02 161
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6UUN 6UUN_refined 3.0 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP2
- adrenomedullin
peptide Agonist adrenomedullin, &alp... peptide Sexton PM 10.1021/ACSPTSCI.9B00080 2020-03-25 35
Gs αs Human - 90 β1 Human γ2 Human cryo-EM 6X18 6X18_refined 2.1 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - glucagon pubchem
peptide Agonist glucagon, glucagon-l... peptide Wootten D 10.1101/2020.08.16.252585 2020-09-09 89
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6M1I 6M1I_refined 3.5 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - PACAP pubchem
peptide Agonist VIP, PACAP-27, PACAP... peptide Ma Y 10.1038/S41422-020-0280-2 2020-03-11 68
Gi/o αt1 Bovine - 59 β1 Bovine γT1 Bovine cryo-EM 6OYA 6OYA_refined 3.3 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - Camelid antibody VHH fragment - Retinal (11-cis) pubchem
small molecule Agonist Retinal small molecule Skiniotis G 10.1016/J.MOLCEL.2019.06.007 2019-07-24 195
Gs αs Bovine - 0 β1 Bovine γ2 Bovine cryo-EM 7JJO 7JJO_refined 2.6 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey - Nanobody-35 - Isoprenaline pubchem
small molecule Agonist (-)-adrenaline, (-)-... small molecule Huang X 10.1016/J.MOLCEL.2020.08.001 2020-09-02 110
Gs αs Human - 89 β1 Human γ2 Human cryo-EM 6X1A 6X1A_refined 2.5 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - PF-06882961 pubchem
small molecule Agonist glucagon, glucagon-l... peptide Wootten D 10.1101/2020.08.16.252585 2020-09-09 86
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6UVA 6UVA_refined 2.3 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP3
- Adrenomedullin-2
peptide Agonist adrenomedullin, &alp... peptide Sexton PM 10.1021/ACSPTSCI.9B00080 2020-04-01 41
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 7CFM 7CFM_refined 3.0 GPBAR GPBA Bile acid A (Rhodopsin) Human - Nanobody-35 - P395 pubchem chembl_ligand
none Agonist chenodeoxycholic aci... small molecule Zhang Y 10.1038/S41586-020-2569-1 2020-09-09 80
Gs αs Human - 47 β1 Human γ2 Human cryo-EM 5UZ7 5UZ7_refined 4.1 CALCR CT Calcitonin B1 (Secretin) Human - - - - - - calcitonin, adrenome... peptide Sexton PM 10.1038/NATURE22327 2017-05-03 2
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6WHC 6WHC_refined 3.4 GLR glucagon Glucagon B1 (Secretin) Human - Nanobody-35 - Dual-agonist peptide...
peptide Agonist glucagon peptide Sexton PM 10.1074/JBC.RA120.013793 2020-05-27 53
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 6KPF - 2.9 CNR2 CB2 Cannabinoid A (Rhodopsin) Human - scFv16 - (6Ar,9R,10aR)-9-(hyd... pubchem
small molecule Agonist 2-arachidonoylglycer... small molecule Liu Z 10.1016/J.CELL.2020.01.008 2020-02-12 140
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 6OS9 6OS9_refined 3.0 NTR1 NTS1 Neurotensin A (Rhodopsin) Human - scFv16 - JMV449 pubchem
peptide Agonist neurotensin, large n... peptide Skiniotis G 10.1038/S41586-019-1337-6 2019-07-10 128
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6WI9 6WI9_refined 4.3 SCTR secretin Glucagon B1 (Secretin) Human - Nanobody-35 - secretin
peptide Agonist secretin, VIP peptide Miller LJ 10.1038/S41467-020-17791-4 2020-08-12 59
Gs αs Human - 50 β1 Bovine γ2 Bovine cryo-EM 7BZ2 7BZ2_refined 3.8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human - Nanobody-35 - Formoterol pubchem chembl_ligand
small molecule Agonist (-)-adrenaline, (-)-... small molecule Tian C 10.1038/S41421-020-0176-9 2020-08-05 74
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 6OT0 6OT0_refined 3.9 SMO SMO Frizzled F (Frizzled) Human - Fab light chain
Fab heavy chain
- 24,25-Epoxy-choleste... pubchem
small molecule Agonist constitutive constitutive Li X 10.1038/S41586-019-1286-0 2019-06-12 125
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6DDF 6DDF_refined 3.5 OPRM μ Opioid A (Rhodopsin) Mouse - - - DAMGO pubchem chembl_ligand
peptide Agonist [Leu]enkephalin, [Me... peptide Kobilka BK 10.1038/S41586-018-0219-7 2018-06-13 116
Gs αs Human - 59 β1 Rat γ2 Bovine cryo-EM 5VAI 5VAI_refined 4.1 G1SGD4 GLP-1 Glucagon B1 (Secretin) Rabbit - - - GLP-1 pubchem
peptide Agonist glucagon, glucagon-l... peptide Skiniotis G 10.1038/NATURE22394 2017-05-24 8
Gi/o αi1 Human - 100 β1 Rat γ2 Bovine cryo-EM 6CMO 6CMO_refined 4.5 OPSD Rhodopsin Opsins A (Rhodopsin) Human BRIL Fab - Apo (no ligand)
none Apo (no ligand) Retinal small molecule Xu HE 10.1038/S41586-018-0215-Y 2018-06-20 119
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 6LMK 6LMK_refined 3.7 GLR glucagon Glucagon B1 (Secretin) Human - Nanobody-35 - glucagon pubchem
peptide Agonist glucagon peptide Wu B 10.1126/SCIENCE.AAZ5346 2020-04-01 44
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBJ 6XBJ_refined 3.9 SMO SMO Frizzled F (Frizzled) Human - scFv16 - Cholesterol pubchem
N/A Agonist constitutive constitutive Li X 10.1038/S41589-020-0646-2 2020-09-30 167
Gi/o αo Human mini-Go 51 - - - - X-ray 6FUF 6FUF_refined 3.1 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - - - Retinal (11-cis) pubchem
small molecule Agonist Retinal small molecule Schertler GFX 10.1126/SCIADV.AAT7052 2018-10-03 179
Gs αs Bovine - 57 β1 Rat γ2 Bovine cryo-EM 6NBH - 3.5 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human - Nanobody-35 - Long-acting parathyr...
peptide Agonist PTHrP, TIP39, PTH, P... protein Zhang Y 10.1126/SCIENCE.AAV7942 2019-04-17 104
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6DDE 6DDE_refined 3.5 OPRM μ Opioid A (Rhodopsin) Mouse - Antibody - DAMGO pubchem chembl_ligand
peptide Agonist [Leu]enkephalin, [Me... peptide Kobilka BK 10.1038/S41586-018-0219-7 2018-06-13 113
Gs αs Human - 54 β1 Human γ2 Human cryo-EM 6M1H 6M1H_refined 3.6 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - Maxadilan pubchem
peptide Agonist VIP, PACAP-27, PACAP... peptide Ma Y 10.1038/S41422-020-0280-2 2020-03-11 65
Gi/o αi1 Human - 60 β1 Bovine γT1 Bovine cryo-EM 6QNO 6QNO_refined 4.4 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - Fab antibody fragment light chain
Fab antibody fragment heavy chain
- Retinal (11-cis) pubchem
small molecule Agonist Retinal small molecule Schertler G 10.7554/ELIFE.46041 2019-07-10 134
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6ORV - 3.0 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - TT-OAD2 pubchem
small molecule Agonist glucagon, glucagon-l... peptide Wootten D 10.1038/s41586-019-1902-z 2020-01-08 71
Gi/o αt1 Bovine - 64 β1 Bovine γT1 Bovine cryo-EM 6OY9 6OY9_refined 3.9 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - - - Retinal (11-cis) pubchem
small molecule Agonist Retinal small molecule Skiniotis G 10.1016/J.MOLCEL.2019.06.007 2019-07-24 192
Gi/o αi1 Human - 63 β1 Human γ2 Human cryo-EM 6LML 6LML_refined 3.9 GLR glucagon Glucagon B1 (Secretin) Human - scFv16 - glucagon pubchem
peptide Agonist glucagon peptide Wu B 10.1126/SCIENCE.AAZ5346 2020-04-01 149
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 6NI3 6NI3_refined 3.8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human - Nanobody-35 - BI-167107 pubchem
small molecule Agonist (-)-adrenaline, (-)-... small molecule Lefkowitz RJ 10.1038/S41594-019-0330-Y 2019-11-20 17