GPR52 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6LI3

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41586-020-2019-0

PUBLICATION DATE

Feb. 26, 2020

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

ENDOGENOUS LIGANDS

No endogenous ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL1 H 73 12x52 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 146 34x50 G.H5 Q 384 G.H5.16
Polar TM5 R 240 5x76 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 240 5x76 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 240 5x76 G.h4s6 Y 358 G.h4s6.20
Polar TM3 D 138 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM5 F 244 5x80 G.H4 L 346 G.H4.16
Van-der-waals TM5 F 244 5x80 G.H4 L 346 G.H4.16
Hydrophobic TM6 L 267 6x37 G.H5 E 392 G.H5.24
Polar TM3 I 143 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 267 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 267 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 C 230 5x66 G.H5 L 393 G.H5.25
Ionic TM5 H 233 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 233 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM3 A 142 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 147 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 N 150 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 N 150 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 146 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 146 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL3 H 247 - G.h4s6 A 351 G.h4s6.04
Polar TM5 R 241 5x77 G.h4s6 D 354 G.h4s6.10
Van-der-waals TM5 R 241 5x77 G.h4s6 D 354 G.h4s6.10
Polar TM5 R 240 5x76 G.S6 C 359 G.S6.01
Van-der-waals TM5 R 240 5x76 G.S6 C 359 G.S6.01
Hydrophobic TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 143 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 143 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 C 230 5x66 G.H5 L 394 G.H5.26
Polar TM5 H 233 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 233 5x69 G.H5 Q 384 G.H5.16
Polar TM5 E 236 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM5 H 233 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 233 5x69 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 233 5x69 G.H5 R 385 G.H5.17
Polar TM5 R 243 5x79 G.hgh4 P 321 G.hgh4.11
Hydrophobic TM5 R 243 5x79 G.hgh4 P 321 G.hgh4.11
Van-der-waals TM5 R 243 5x79 G.hgh4 P 321 G.hgh4.11
Polar TM2 Y 74 2x37 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 P 146 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 146 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 I 237 5x73 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 237 5x73 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 240 5x76 G.S6 P 361 G.S6.03
Van-der-waals TM5 R 240 5x76 G.S6 P 361 G.S6.03
Hydrophobic TM6 F 268 6x38 G.H5 L 393 G.H5.25
Van-der-waals TM6 F 268 6x38 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 237 5x73 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 237 5x73 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 233 5x69 G.H5 L 388 G.H5.20
Hydrophobic TM5 F 244 5x80 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 F 244 5x80 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 F 244 5x80 G.H4 D 343 G.H4.13
Van-der-waals TM5 F 244 5x80 G.H4 D 343 G.H4.13
Hydrophobic ICL2 L 147 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM5 R 240 5x76 G.H4 L 346 G.H4.16
Hydrophobic ICL2 L 147 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 147 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM2 T 76 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 76 2x39 G.H5 Y 391 G.H5.23