CXCR2 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6LFM

RESOLUTION

3.5 Å

REFERENCE

10.1038/S41586-020-2492-5

PUBLICATION DATE

Sept. 2, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

69 interactions (Click to see)

LIGANDS

Interleukin-8 - Agonist pubchem

ENDOGENOUS LIGANDS

CXCL3, CXCL1, CXCL6, CXCL2, CXCL7, CXCL5, CXCL8



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 S 81 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 81 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 81 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM6 A 249 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 148 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 T 152 34x51 G.H5 F 336 G.H5.08
Polar ICL2 L 155 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 152 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL3 M 243 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 M 243 - G.H5 K 345 G.H5.17
Polar TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 R 159 34x58 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 159 34x58 G.HN E 28 G.HN.52
Hydrophobic TM3 I 148 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 348 G.H5.20
Polar H8 G 318 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 318 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 318 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 K 320 8x49 G.H5 D 350 G.H5.22
Polar H8 Q 319 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM3 A 147 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 151 34x50 G.H5 I 343 G.H5.15
Hydrophobic H8 Q 319 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 Q 319 8x48 G.H5 K 349 G.H5.21
Hydrophobic TM5 L 238 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 249 6x33 G.H5 L 353 G.H5.25
Polar TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 238 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL3 M 243 - G.H5 L 348 G.H5.20
Polar TM6 R 248 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 248 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM5 T 237 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 148 3x54 G.H5 I 344 G.H5.16
Polar ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM7 I 317 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 I 317 7x56 G.H5 G 352 G.H5.24
Polar TM6 R 248 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 248 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 I 253 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 151 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM2 T 83 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 252 6x36 G.H5 L 353 G.H5.25
Van-der-waals ICL2 R 159 34x58 G.hns1 R 32 G.hns1.03
Ionic ICL3 H 242 - G.H5 D 341 G.H5.13
Polar ICL3 H 242 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 H 242 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 H 242 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 243 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 M 243 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 Q 245 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 Q 245 - G.H5 F 354 G.H5.26
Polar ICL3 M 243 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 243 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 M 243 - G.H5 D 341 G.H5.13