D4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IRU

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41422-023-00808-0

PUBLICATION DATE

June 21, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

58 interactions (Click to see)

LIGANDS

rotigotine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

ENDOGENOUS LIGANDS

dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 R 226 5x72 G.S6 Y 327 G.S6.02
Hydrophobic ICL4 F 403 - G.H5 G 359 G.H5.24
Hydrophobic TM3 R 133 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 133 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM6 K 343 6x32 G.H5 F 361 G.H5.26
Van-der-waals TM6 K 343 6x32 G.H5 F 361 G.H5.26
Hydrophobic ICL2 P 140 - G.H5 T 347 G.H5.12
Van-der-waals ICL2 P 140 - G.H5 T 347 G.H5.12
Polar TM3 A 136 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 136 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 136 3x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 L 141 - G.S3 V 194 G.S3.01
Van-der-waals ICL2 L 141 - G.S3 V 194 G.S3.01
Polar H8 N 404 8x47 G.H5 D 357 G.H5.22
Van-der-waals H8 N 404 8x47 G.H5 D 357 G.H5.22
Hydrophobic ICL2 P 140 - G.H5 I 351 G.H5.16
Van-der-waals ICL2 P 140 - G.H5 I 351 G.H5.16
Hydrophobic ICL2 Y 143 - G.H5 N 354 G.H5.19
Van-der-waals ICL2 Y 143 - G.H5 N 354 G.H5.19
Hydrophobic ICL2 L 141 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 L 141 - G.H5 I 350 G.H5.15
Hydrophobic ICL2 N 144 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 N 144 - G.H5 I 350 G.H5.15
Polar ICL2 R 145 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 145 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 145 - G.hns1 R 31 G.hns1.02
Polar TM6 A 344 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM6 A 344 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 A 344 6x33 G.H5 L 360 G.H5.25
Polar ICL2 N 144 - G.H5 N 354 G.H5.19
Van-der-waals ICL2 N 144 - G.H5 N 354 G.H5.19
Hydrophobic ICL2 L 141 - G.S1 H 34 G.S1.02
Van-der-waals ICL2 L 141 - G.S1 H 34 G.S1.02
Hydrophobic TM5 T 215 5x61 G.H5 L 360 G.H5.25
Hydrophobic TM6 K 343 6x32 G.H5 L 360 G.H5.25
Polar TM3 R 133 3x50 G.H5 C 358 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 C 358 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 C 358 G.H5.23
Van-der-waals TM5 W 222 5x68 G.H5 K 352 G.H5.17
Hydrophobic ICL2 L 141 - G.H5 F 343 G.H5.08
Hydrophobic ICL2 Q 146 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 Q 146 - G.hns1 R 31 G.hns1.02
Hydrophobic TM5 L 219 5x65 G.H5 L 355 G.H5.20
Van-der-waals TM5 L 219 5x65 G.H5 L 355 G.H5.20
Van-der-waals TM6 K 343 6x32 G.H5 G 359 G.H5.24
Hydrophobic ICL2 P 140 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 140 - G.H5 I 350 G.H5.15
Ionic TM5 R 226 5x72 G.H5 D 348 G.H5.13
Polar TM5 R 226 5x72 G.H5 D 348 G.H5.13
Hydrophobic TM5 R 226 5x72 G.H5 D 348 G.H5.13
Van-der-waals TM5 R 226 5x72 G.H5 D 348 G.H5.13
Polar H8 N 404 8x47 G.H5 G 359 G.H5.24
Hydrophobic H8 N 404 8x47 G.H5 G 359 G.H5.24
Van-der-waals H8 N 404 8x47 G.H5 G 359 G.H5.24
Hydrophobic ICL2 L 141 - G.H5 T 347 G.H5.12
Van-der-waals ICL2 L 141 - G.H5 T 347 G.H5.12
Ionic ICL2 R 145 - G.H5 D 357 G.H5.22
Polar ICL2 R 145 - G.H5 D 357 G.H5.22
Hydrophobic ICL2 R 145 - G.H5 D 357 G.H5.22
Van-der-waals ICL2 R 145 - G.H5 D 357 G.H5.22
Polar TM5 W 222 5x68 G.H5 D 348 G.H5.13
Hydrophobic TM5 W 222 5x68 G.H5 D 348 G.H5.13
Van-der-waals TM5 W 222 5x68 G.H5 D 348 G.H5.13
Hydrophobic TM3 V 137 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 137 3x54 G.H5 L 355 G.H5.20
Polar ICL2 P 140 - G.H5 N 354 G.H5.19
Van-der-waals ICL2 P 140 - G.H5 N 354 G.H5.19
Hydrophobic TM2 T 69 2x39 G.H5 D 357 G.H5.22
Van-der-waals TM2 T 69 2x39 G.H5 D 357 G.H5.22
Hydrophobic TM5 W 222 5x68 G.H5 I 351 G.H5.16
Van-der-waals TM5 W 222 5x68 G.H5 I 351 G.H5.16
Hydrophobic TM6 V 347 6x36 G.H5 L 360 G.H5.25
Van-der-waals TM6 V 347 6x36 G.H5 L 360 G.H5.25
Hydrophobic TM6 L 348 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 348 6x37 G.H5 L 360 G.H5.25
Polar ICL2 Q 146 - G.hns1 A 32 G.hns1.03
Van-der-waals ICL2 Q 146 - G.hns1 A 32 G.hns1.03
Van-der-waals ICL2 N 144 - G.H5 M 353 G.H5.18
Hydrophobic TM2 T 69 2x39 G.H5 C 358 G.H5.23
Van-der-waals TM2 T 69 2x39 G.H5 C 358 G.H5.23
Hydrophobic TM3 A 136 3x53 G.H5 C 358 G.H5.23