C3a receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

C

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

May 10, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

ENDOGENOUS LIGANDS

C3a, C5a



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 V 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 123 3x53 G.H5 N 347 G.H5.19
Polar ICL3 K 370 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 K 370 - G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 M 363 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 M 363 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 F 368 - G.H5 F 334 G.H5.06
Aromatic ICL3 F 368 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 F 368 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 F 368 - G.S6 Y 320 G.S6.02
Hydrophobic ICL4 L 438 - G.H5 G 352 G.H5.24
Polar ICL3 K 370 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 K 370 - G.h4s6 K 314 G.h4s6.08
Polar H8 K 440 8x48 G.H5 K 349 G.H5.21
Hydrophobic H8 K 440 8x48 G.H5 K 349 G.H5.21
Polar TM2 N 57 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 N 57 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 N 57 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 K 374 6x32 G.H5 F 354 G.H5.26
Polar ICL3 F 368 - G.H5 K 345 G.H5.17
Ionic ICL3 K 370 - G.h4s6 E 318 G.h4s6.12
Ionic ICL3 R 367 - G.H5 D 337 G.H5.09
Polar ICL3 R 367 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 I 128 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 R 367 - G.H5 F 334 G.H5.06
Polar H8 K 440 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 440 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 120 3x50 G.H5 L 353 G.H5.25
Polar ICL2 N 132 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 132 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 132 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 R 134 34x57 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 134 34x57 G.H5 N 347 G.H5.19
Hydrophobic TM5 M 363 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 124 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 I 128 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 Q 131 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 131 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL4 G 439 - G.H5 G 352 G.H5.24
Polar ICL2 N 132 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 132 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 P 127 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 127 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM5 Y 356 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 124 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL3 F 368 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 I 128 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 128 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 Q 372 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 372 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 378 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Polar TM2 N 57 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 57 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Polar TM6 T 375 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 375 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 375 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 131 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 131 34x54 G.hns1 R 32 G.hns1.03