Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
15931130 101511 0 None 1000 2 Rat 9.4 pEC50 = 9.4 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL301477 101511 0 None 1000 2 Rat 9.4 pEC50 = 9.4 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44297866 101574 0 None 38 2 Rat 9.4 pEC50 = 9.4 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL301841 101574 0 None 38 2 Rat 9.4 pEC50 = 9.4 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
2089 2725 21 None -3 8 Rat 9.3 pEC50 = 9.3 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
ChEMBL None None None None 10.1021/jm900671k
3795 2725 21 None -3 8 Rat 9.3 pEC50 = 9.3 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
ChEMBL None None None None 10.1021/jm900671k
5311311 2725 21 None -3 8 Rat 9.3 pEC50 = 9.3 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
ChEMBL None None None None 10.1021/jm900671k
CHEMBL217406 2725 21 None -3 8 Rat 9.3 pEC50 = 9.3 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
ChEMBL None None None None 10.1021/jm900671k
2098 3638 31 None -63 11 Rat 9.0 pEC50 = 9 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
36511 3638 31 None -63 11 Rat 9.0 pEC50 = 9 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
3805 3638 31 None -63 11 Rat 9.0 pEC50 = 9 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
3835 3638 31 None -63 11 Rat 9.0 pEC50 = 9 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 3638 31 None -63 11 Rat 9.0 pEC50 = 9 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
44355179 24144 0 None 33 2 Rat 8.9 pEC50 = 8.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134091 24144 0 None 33 2 Rat 8.9 pEC50 = 8.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
2089 2725 21 None -3 8 Rat 8.8 pEC50 = 8.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
3795 2725 21 None -3 8 Rat 8.8 pEC50 = 8.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
5311311 2725 21 None -3 8 Rat 8.8 pEC50 = 8.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL217406 2725 21 None -3 8 Rat 8.8 pEC50 = 8.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
73356363 89074 0 None -9 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372949 89074 0 None -9 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
10055612 95978 0 None -31 3 Rat 5.9 pEC50 = 5.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262049 95978 0 None -31 3 Rat 5.9 pEC50 = 5.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
10327810 116236 0 None 31 2 Rat 5.9 pEC50 = 5.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337465 116236 0 None 31 2 Rat 5.9 pEC50 = 5.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10259515 156595 0 None -954 2 Rat 4.9 pEC50 = 4.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL407511 156595 0 None -954 2 Rat 4.9 pEC50 = 4.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
44355678 23286 0 None -4 2 Rat 5.9 pEC50 = 5.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL133362 23286 0 None -4 2 Rat 5.9 pEC50 = 5.9 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10462850 24059 0 None 36 2 Rat 7.8 pEC50 = 7.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134012 24059 0 None 36 2 Rat 7.8 pEC50 = 7.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
2098 3638 31 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
36511 3638 31 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
3805 3638 31 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
3835 3638 31 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL235363 3638 31 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
2098 3638 31 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
36511 3638 31 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
3805 3638 31 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
3835 3638 31 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 3638 31 None -63 11 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
73348740 89076 0 None -51 2 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372953 89076 0 None -51 2 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44297675 100153 0 None 47 2 Rat 8.6 pEC50 = 8.6 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL291903 100153 0 None 47 2 Rat 8.6 pEC50 = 8.6 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
10395375 116157 0 None 2 2 Rat 5.7 pEC50 = 5.7 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337037 116157 0 None 2 2 Rat 5.7 pEC50 = 5.7 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
2090 2726 20 None -6 9 Rat 7.6 pEC50 = 7.6 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
5311312 2726 20 None -6 9 Rat 7.6 pEC50 = 7.6 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL437797 2726 20 None -6 9 Rat 7.6 pEC50 = 7.6 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL335054 209734 0 None 20 3 Rat 8.5 pEC50 = 8.5 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
5311135 21523 10 None 316 3 Rat 8.4 pEC50 = 8.4 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131872 21523 10 None 316 3 Rat 8.4 pEC50 = 8.4 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134481 206987 0 None 1 3 Rat 7.5 pEC50 = 7.5 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm00100a027
44355648 96676 0 None 22 3 Rat 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL267712 96676 0 None 22 3 Rat 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
10350201 116659 0 None 6 2 Rat 6.3 pEC50 = 6.3 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL339391 116659 0 None 6 2 Rat 6.3 pEC50 = 6.3 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
44355117 21588 0 None 19 3 Rat 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131923 21588 0 None 19 3 Rat 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
44297786 101239 0 None - 1 Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL299503 101239 0 None - 1 Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
44355368 25437 0 None 1 3 Rat 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL135186 25437 0 None 1 3 Rat 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
2089 2725 21 None -3 8 Rat 7.2 pEC50 = 7.2 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
ChEMBL None None None None 10.1021/jm900671k
3795 2725 21 None -3 8 Rat 7.2 pEC50 = 7.2 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
ChEMBL None None None None 10.1021/jm900671k
5311311 2725 21 None -3 8 Rat 7.2 pEC50 = 7.2 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
ChEMBL None None None None 10.1021/jm900671k
CHEMBL217406 2725 21 None -3 8 Rat 7.2 pEC50 = 7.2 Functional
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
ChEMBL None None None None 10.1021/jm900671k
15931129 193308 0 None -1 2 Rat 8.2 pEC50 = 8.2 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL54622 193308 0 None -1 2 Rat 8.2 pEC50 = 8.2 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44297852 98550 0 None 7 2 Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL280020 98550 0 None 7 2 Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
11765601 95977 0 None 9 2 Rat 7.0 pEC50 = 7.0 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262048 95977 0 None 9 2 Rat 7.0 pEC50 = 7.0 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
10009596 115010 0 None -1 2 Rat 7.0 pEC50 = 7.0 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
CHEMBL335248 115010 0 None -1 2 Rat 7.0 pEC50 = 7.0 Functional
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
145953024 162040 0 None -4 5 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4168948 162040 0 None -4 5 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
145952624 161835 0 None -1 4 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 889 21 2 10 3.3 CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4165525 161835 0 None -1 4 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 889 21 2 10 3.3 CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
10917690 205871 0 None -645 4 Human 5.5 pIC50 = 5.5 Functional
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL95051 205871 0 None -645 4 Human 5.5 pIC50 = 5.5 Functional
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
145957924 161544 0 None -1 4 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4161021 161544 0 None -1 4 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL412740 211274 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1ccc(/N=C(\S)Cc2ccccc2)cc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCS)C(N)=O 10.1016/S0960-894X(97)00088-7
145958767 161705 0 None 1 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 932 22 2 11 2.8 CC[C@H](C)[C@@H](OC(=O)[C@H](Cc1ccccc1)N(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4163618 161705 0 None 1 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 932 22 2 11 2.8 CC[C@H](C)[C@@H](OC(=O)[C@H](Cc1ccccc1)N(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
2089 2725 21 None -3 8 Human 8.1 pIC50 = 8.1 Functional
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None None 10.1016/S0960-894X(97)00088-7
3795 2725 21 None -3 8 Human 8.1 pIC50 = 8.1 Functional
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None None 10.1016/S0960-894X(97)00088-7
5311311 2725 21 None -3 8 Human 8.1 pIC50 = 8.1 Functional
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None None 10.1016/S0960-894X(97)00088-7
CHEMBL217406 2725 21 None -3 8 Human 8.1 pIC50 = 8.1 Functional
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None None 10.1016/S0960-894X(97)00088-7
CHEMBL264972 208888 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1ccc(NC(=S)c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCS)C(N)=O 10.1016/S0960-894X(97)00088-7
153996 112171 2 None -2 6 Human 8.1 pIC50 = 8.1 Functional
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330366 112171 2 None -2 6 Human 8.1 pIC50 = 8.1 Functional
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL539021 112171 2 None -2 6 Human 8.1 pIC50 = 8.1 Functional
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44392439 167811 0 None - 1 Rabbit 10.1 pKd = 10.1 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 557 7 1 4 5.2 O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL434548 167811 0 None - 1 Rabbit 10.1 pKd = 10.1 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 557 7 1 4 5.2 O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
11433617 6693 0 None - 0 Human 9.7 pKd = 9.7 Functional
Antagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractionsAntagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractions
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083850 6693 0 None - 0 Human 9.7 pKd = 9.7 Functional
Antagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractionsAntagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractions
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
44392392 129651 0 None - 1 Rabbit 9.7 pKd = 9.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 555 7 0 4 5.4 O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL367815 129651 0 None - 1 Rabbit 9.7 pKd = 9.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 555 7 0 4 5.4 O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392491 167747 0 None - 1 Rabbit 9.7 pKd = 9.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 556 7 1 4 5.2 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL434142 167747 0 None - 1 Rabbit 9.7 pKd = 9.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 556 7 1 4 5.2 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392318 122028 0 None - 0 Rabbit 9.6 pKd = 9.6 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 519 7 0 4 5.0 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL360134 122028 0 None - 0 Rabbit 9.6 pKd = 9.6 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 519 7 0 4 5.0 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
44346720 114337 0 None - 0 Golden hamster 9.3 pKd = 9.3 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 849 14 9 8 1.8 CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL334186 114337 0 None - 0 Golden hamster 9.3 pKd = 9.3 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 849 14 9 8 1.8 CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
71452717 78488 0 None - 0 Rabbit 9.2 pKd = 9.2 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 678 7 5 6 1.6 O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112925 78488 0 None - 0 Rabbit 9.2 pKd = 9.2 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 678 7 5 6 1.6 O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
9959481 64888 0 None - 1 Human 9.2 pKd = 9.2 Functional
pA2 for NK2 receptor of human bladder IM9 cellspA2 for NK2 receptor of human bladder IM9 cells
ChEMBL 559 7 0 3 6.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL182600 64888 0 None - 1 Human 9.2 pKd = 9.2 Functional
pA2 for NK2 receptor of human bladder IM9 cellspA2 for NK2 receptor of human bladder IM9 cells
ChEMBL 559 7 0 3 6.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
71449111 78485 0 None - 0 Rabbit 9.1 pKd = 9.1 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112922 78485 0 None - 0 Rabbit 9.1 pKd = 9.1 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44346727 167605 0 None - 0 Golden hamster 9.1 pKd = 9.1 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 784 11 8 7 2.7 CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL433191 167605 0 None - 0 Golden hamster 9.1 pKd = 9.1 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 784 11 8 7 2.7 CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44374427 54508 0 None - 0 Rabbit 9.0 pKd = 9 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 765 12 6 8 0.9 O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL161242 54508 0 None - 0 Rabbit 9.0 pKd = 9 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 765 12 6 8 0.9 O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
71458042 78486 0 None - 0 Rabbit 9.0 pKd = 9 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 692 8 5 6 2.0 O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112923 78486 0 None - 0 Rabbit 9.0 pKd = 9 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 692 8 5 6 2.0 O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44392351 66069 0 None - 1 Rabbit 9.0 pKd = 9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 620 8 0 5 4.3 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185182 66069 0 None - 1 Rabbit 9.0 pKd = 9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 620 8 0 5 4.3 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
10929285 66376 0 None - 1 Rabbit 9.0 pKd = 9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL185572 66376 0 None - 1 Rabbit 9.0 pKd = 9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1016/j.bmcl.2005.05.134
10940813 65999 0 None - 1 Rabbit 8.9 pKd = 8.9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185007 65999 0 None - 1 Rabbit 8.9 pKd = 8.9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392347 121614 0 None - 1 Rabbit 8.9 pKd = 8.9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 543 7 0 4 5.1 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL359655 121614 0 None - 1 Rabbit 8.9 pKd = 8.9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 543 7 0 4 5.1 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
9915372 126538 1 None - 1 Rabbit 8.9 pKd = 8.9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL365613 126538 1 None - 1 Rabbit 8.9 pKd = 8.9 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
9915372 126538 1 None - 1 Human 8.8 pKd = 8.8 Functional
pA2 for NK2 receptor of Human bladderpA2 for NK2 receptor of Human bladder
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL365613 126538 1 None - 1 Human 8.8 pKd = 8.8 Functional
pA2 for NK2 receptor of Human bladderpA2 for NK2 receptor of Human bladder
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392445 66023 0 None - 1 Rabbit 8.8 pKd = 8.8 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 495 8 0 3 5.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185133 66023 0 None - 1 Rabbit 8.8 pKd = 8.8 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 495 8 0 3 5.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1 10.1016/j.bmcl.2005.05.134
44346794 15099 0 None - 0 Golden hamster 8.8 pKd = 8.8 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 828 11 8 7 3.1 CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL121271 15099 0 None - 0 Golden hamster 8.8 pKd = 8.8 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 828 11 8 7 3.1 CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
10972666 122431 0 None - 1 Rabbit 8.7 pKd = 8.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 465 7 0 4 3.7 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL360721 122431 0 None - 1 Rabbit 8.7 pKd = 8.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 465 7 0 4 3.7 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
10950925 129132 0 None - 1 Rabbit 8.7 pKd = 8.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL367348 129132 0 None - 1 Rabbit 8.7 pKd = 8.7 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
9830361 181044 0 None - 0 Human 8.0 pKd = 8 Functional
Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2
ChEMBL 538 7 1 4 7.1 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL47739 181044 0 None - 0 Human 8.0 pKd = 8 Functional
Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2
ChEMBL 538 7 1 4 7.1 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
10232566 4154 0 None - 0 Human 8.0 pKd = 8 Functional
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2
ChEMBL 607 12 2 4 6.1 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL100297 4154 0 None - 0 Human 8.0 pKd = 8 Functional
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2
ChEMBL 607 12 2 4 6.1 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44307677 168698 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 168698 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44370530 48858 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL156186 48858 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
9810288 201996 0 None - 0 Guinea pig 7.0 pKd = 7 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67508 201996 0 None - 0 Guinea pig 7.0 pKd = 7 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44346881 140991 0 None - 0 Golden hamster 7.0 pKd = 7 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 923 13 9 9 1.5 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O 10.1021/jm00047a020
CHEMBL384610 140991 0 None - 0 Golden hamster 7.0 pKd = 7 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 923 13 9 9 1.5 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O 10.1021/jm00047a020
10350528 106251 0 None - 4 Rabbit 5.0 pKd = 5 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106251 0 None - 4 Rabbit 5.0 pKd = 5 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10439730 106275 0 None - 4 Rabbit 5.0 pKd = 5 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106275 0 None - 4 Rabbit 5.0 pKd = 5 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL413730 211337 0 None - 0 Golden hamster 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None None 10.1021/jm00014a022
CHEMBL217365 207629 0 None - 0 Rabbit 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL262647 208798 0 None - 0 Rabbit 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
CHEMBL263985 208855 0 None - 0 Rabbit 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL329888 209576 0 None - 0 Rabbit 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL412621 211263 0 None - 0 Rabbit 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm00014a022
CHEMBL413730 211337 0 None - 0 Rabbit 4.0 pKd = 4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None None 10.1021/jm00014a022
44346487 113631 0 None - 0 Rabbit 6.0 pKd = 6.0 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 746 11 9 8 0.2 CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL332872 113631 0 None - 0 Rabbit 6.0 pKd = 6.0 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 746 11 9 8 0.2 CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346706 167606 0 None - 0 Golden hamster 7.0 pKd = 7.0 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 745 11 9 8 -0.4 CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL433192 167606 0 None - 0 Golden hamster 7.0 pKd = 7.0 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 745 11 9 8 -0.4 CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL406487 210863 0 None - 0 Golden hamster 6.0 pKd = 6.0 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44347003 163626 0 None - 0 Rabbit 7.0 pKd = 7.0 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 744 11 8 7 1.7 CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL421062 163626 0 None - 0 Rabbit 7.0 pKd = 7.0 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 744 11 8 7 1.7 CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL216897 207599 0 None - 0 Golden hamster 5.0 pKd = 5.0 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44346707 113997 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 798 11 7 7 3.0 CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL333515 113997 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 798 11 7 7 3.0 CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL407328 210907 0 None - 0 Golden hamster 5.9 pKd = 5.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44307898 199788 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 199788 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44347083 15280 0 None - 0 Golden hamster 7.9 pKd = 7.9 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 762 12 8 8 1.4 CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL121571 15280 0 None - 0 Golden hamster 7.9 pKd = 7.9 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 762 12 8 8 1.4 CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL385603 210610 0 None - 0 Golden hamster 5.9 pKd = 5.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44307821 101644 0 None - 0 Guinea pig 6.9 pKd = 6.9 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 101644 0 None - 0 Guinea pig 6.9 pKd = 6.9 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10259370 106266 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144340 106266 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL412189 211228 0 None - 0 Rabbit 5.9 pKd = 5.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
10418001 106271 0 None - 0 Rabbit 5.9 pKd = 5.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144348 106271 0 None - 0 Rabbit 5.9 pKd = 5.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10349900 106267 0 None - 4 Rabbit 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106267 0 None - 4 Rabbit 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10395494 106272 0 None - 0 Rabbit 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144349 106272 0 None - 0 Rabbit 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44347084 113754 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 893 16 9 9 2.8 CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL333027 113754 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 893 16 9 9 2.8 CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346863 165831 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 909 13 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL427606 165831 0 None - 0 Rabbit 6.9 pKd = 6.9 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 909 13 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL263743 208843 0 None - 0 Rabbit 4.9 pKd = 4.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None None 10.1021/jm00014a022
CHEMBL385914 210622 0 None - 0 Rabbit 5.9 pKd = 5.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
CHEMBL439287 212084 0 None - 0 Golden hamster 5.9 pKd = 5.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00014a022
CHEMBL267409 208975 0 None - 0 Golden hamster 6.9 pKd = 6.9 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O 10.1021/jm00014a022
CHEMBL329888 209576 0 None - 0 Rat 4.9 pKd = 4.9 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL387199 210660 0 None - 0 Golden hamster 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44346488 163636 0 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 798 11 8 7 2.2 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O 10.1021/jm00047a020
CHEMBL421071 163636 0 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 798 11 8 7 2.2 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O 10.1021/jm00047a020
CHEMBL267409 208975 0 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O 10.1021/jm00014a022
CHEMBL329888 209576 0 None - 0 Golden hamster 4.8 pKd = 4.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
44346720 114337 0 None - 0 Rabbit 7.8 pKd = 7.8 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 849 14 9 8 1.8 CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL334186 114337 0 None - 0 Rabbit 7.8 pKd = 7.8 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 849 14 9 8 1.8 CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44307679 201823 0 None - 0 Guinea pig 7.8 pKd = 7.8 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 201823 0 None - 0 Guinea pig 7.8 pKd = 7.8 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44347003 163626 0 None - 0 Golden hamster 7.8 pKd = 7.8 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 744 11 8 7 1.7 CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL421062 163626 0 None - 0 Golden hamster 7.8 pKd = 7.8 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 744 11 8 7 1.7 CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL439287 212084 0 None - 0 Rat 6.8 pKd = 6.8 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00014a022
CHEMBL217365 207629 0 None - 0 Golden hamster 4.8 pKd = 4.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44307773 101890 0 None - 0 Guinea pig 6.8 pKd = 6.8 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL303803 101890 0 None - 0 Guinea pig 6.8 pKd = 6.8 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL429340 211774 0 None - 0 Golden hamster 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL439284 212083 18 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00063a015
10395612 106265 0 None - 0 Rabbit 4.8 pKd = 4.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144339 106265 0 None - 0 Rabbit 4.8 pKd = 4.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10032981 106270 0 None - 0 Rabbit 4.8 pKd = 4.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144347 106270 0 None - 0 Rabbit 4.8 pKd = 4.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
9832198 106273 0 None - 4 Rabbit 4.8 pKd = 4.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106273 0 None - 4 Rabbit 4.8 pKd = 4.8 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL385603 210610 0 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
CHEMBL439287 212084 0 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00014a022
CHEMBL268563 209014 0 None - 0 Rabbit 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
CHEMBL268563 209014 0 None - 0 Golden hamster 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
CHEMBL412621 211263 0 None - 0 Golden hamster 5.8 pKd = 5.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm00014a022
CHEMBL263743 208843 0 None - 0 Golden hamster 4.8 pKd = 4.8 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None None 10.1021/jm00014a022
44347002 112336 0 None - 0 Golden hamster 7.7 pKd = 7.7 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 778 11 8 7 1.9 CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL330810 112336 0 None - 0 Golden hamster 7.7 pKd = 7.7 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 778 11 8 7 1.9 CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL438716 212040 0 None - 0 Rat 4.7 pKd = 4.7 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
9874206 202075 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 202075 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL412621 211263 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm00014a022
CHEMBL263997 208856 0 None - 0 Rabbit 6.7 pKd = 6.7 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL441181 212133 0 None - 0 Rat 5.7 pKd = 5.7 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
CHEMBL438716 212040 0 None - 0 Rabbit 4.7 pKd = 4.7 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
57391133 68025 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 68025 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
44370713 50759 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL157858 50759 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
10055415 106274 0 None - 4 Rabbit 5.7 pKd = 5.7 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106274 0 None - 4 Rabbit 5.7 pKd = 5.7 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
3086681 2240 14 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 2240 14 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 2240 14 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
10325464 119629 0 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351236 119629 0 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10506928 119713 0 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL352102 119713 0 None - 1 Rabbit 4.7 pKd = 4.7 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10350454 106249 0 None - 4 Rabbit 4.7 pKd = 4.7 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106249 0 None - 4 Rabbit 4.7 pKd = 4.7 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44347001 112685 0 None - 0 Golden hamster 8.7 pKd = 8.7 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 851 15 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL331480 112685 0 None - 0 Golden hamster 8.7 pKd = 8.7 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 851 15 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44374556 52451 0 None - 0 Rabbit 8.6 pKd = 8.6 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 773 9 5 6 3.7 O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL159449 52451 0 None - 0 Rabbit 8.6 pKd = 8.6 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 773 9 5 6 3.7 O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44392444 121820 0 None - 1 Rabbit 8.6 pKd = 8.6 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 481 7 0 3 4.8 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL359903 121820 0 None - 1 Rabbit 8.6 pKd = 8.6 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 481 7 0 3 4.8 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL429340 211774 0 None - 0 Rabbit 7.7 pKd = 7.7 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL263997 208856 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44347083 15280 0 None - 0 Rabbit 6.7 pKd = 6.7 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 762 12 8 8 1.4 CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL121571 15280 0 None - 0 Rabbit 6.7 pKd = 6.7 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 762 12 8 8 1.4 CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL334721 209653 1 None - 2 Guinea pig 7.6 pKd = 7.6 Functional
Compound was evaluated for antagonistic activity towards Tachykinin receptor 2 at guinea pig tracheaCompound was evaluated for antagonistic activity towards Tachykinin receptor 2 at guinea pig trachea
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00282-0
CHEMBL263985 208855 0 None - 0 Rat 5.6 pKd = 5.6 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
9918520 102278 0 None - 0 Guinea pig 7.6 pKd = 7.6 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL305055 102278 0 None - 0 Guinea pig 7.6 pKd = 7.6 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL429340 211774 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL217365 207629 0 None - 0 Rat 4.6 pKd = 4.6 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL266526 208941 0 None - 0 Rabbit 6.6 pKd = 6.6 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL412830 211283 0 None - 0 Rabbit 5.6 pKd = 5.6 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL412189 211228 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
CHEMBL385914 210622 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
71449112 78489 0 None - 0 Rabbit 8.5 pKd = 8.5 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 682 10 8 7 0.3 O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112926 78489 0 None - 0 Rabbit 8.5 pKd = 8.5 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 682 10 8 7 0.3 O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44374557 119090 0 None - 0 Rabbit 8.5 pKd = 8.5 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 693 11 6 6 1.9 CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(01)00841-1
CHEMBL346285 119090 0 None - 0 Rabbit 8.5 pKd = 8.5 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 693 11 6 6 1.9 CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(01)00841-1
9807403 66351 0 None - 1 Rabbit 8.5 pKd = 8.5 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185452 66351 0 None - 1 Rabbit 8.5 pKd = 8.5 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44346707 113997 0 None - 0 Golden hamster 8.4 pKd = 8.4 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 798 11 7 7 3.0 CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL333515 113997 0 None - 0 Golden hamster 8.4 pKd = 8.4 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 798 11 7 7 3.0 CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44370529 48794 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
CHEMBL156128 48794 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
10305816 4155 0 None - 0 Human 8.4 pKd = 8.4 Functional
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2
ChEMBL 736 16 2 6 6.9 O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL100298 4155 0 None - 0 Human 8.4 pKd = 8.4 Functional
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2
ChEMBL 736 16 2 6 6.9 O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44374543 52615 0 None - 0 Rabbit 8.4 pKd = 8.4 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 773 9 5 6 3.7 O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL159585 52615 0 None - 0 Rabbit 8.4 pKd = 8.4 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 773 9 5 6 3.7 O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44374598 118986 0 None - 0 Rabbit 8.4 pKd = 8.4 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 811 10 10 10 -1.2 CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL345402 118986 0 None - 0 Rabbit 8.4 pKd = 8.4 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 811 10 10 10 -1.2 CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL412830 211283 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O 10.1021/jm00014a022
44346486 113624 0 None - 0 Golden hamster 6.5 pKd = 6.5 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 759 13 9 8 0.8 CC(C)C[C@@H]1CN[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL332820 113624 0 None - 0 Golden hamster 6.5 pKd = 6.5 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 759 13 9 8 0.8 CC(C)C[C@@H]1CN[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346488 163636 0 None - 0 Golden hamster 7.5 pKd = 7.5 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 798 11 8 7 2.2 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O 10.1021/jm00047a020
CHEMBL421071 163636 0 None - 0 Golden hamster 7.5 pKd = 7.5 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 798 11 8 7 2.2 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O 10.1021/jm00047a020
10145229 9083 0 None - 0 Golden hamster 6.5 pKd = 6.5 Functional
Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 9083 0 None - 0 Golden hamster 6.5 pKd = 6.5 Functional
Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL263985 208855 0 None - 0 Golden hamster 4.5 pKd = 4.5 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44305816 162469 0 None - 0 Rabbit 4.5 pKd = 4.5 Functional
Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
CHEMBL417572 162469 0 None - 0 Rabbit 4.5 pKd = 4.5 Functional
Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
CHEMBL216897 207599 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL267409 208975 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O 10.1021/jm00014a022
CHEMBL407328 210907 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL385914 210622 0 None - 0 Golden hamster 6.5 pKd = 6.5 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
44346727 167605 0 None - 0 Rabbit 7.4 pKd = 7.4 Functional
Tested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uMTested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uM
ChEMBL 784 11 8 7 2.7 CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL433191 167605 0 None - 0 Rabbit 7.4 pKd = 7.4 Functional
Tested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uMTested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uM
ChEMBL 784 11 8 7 2.7 CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL266526 208941 0 None - 0 Rat 6.4 pKd = 6.4 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL387199 210660 0 None - 0 Rat 6.4 pKd = 6.4 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44307819 102123 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 102123 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307678 196998 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 196998 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307820 201940 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 201940 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
21121353 101003 0 None - 4 Rabbit 5.4 pKd = 5.4 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101003 0 None - 4 Rabbit 5.4 pKd = 5.4 Functional
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
44346863 165831 0 None - 0 Golden hamster 8.4 pKd = 8.4 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 909 13 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL427606 165831 0 None - 0 Golden hamster 8.4 pKd = 8.4 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 909 13 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL406487 210863 0 None - 0 Rabbit 6.4 pKd = 6.4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL262647 208798 0 None - 0 Golden hamster 5.4 pKd = 5.4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
44346794 15099 0 None - 0 Rabbit 7.4 pKd = 7.4 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 828 11 8 7 3.1 CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL121271 15099 0 None - 0 Rabbit 7.4 pKd = 7.4 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 828 11 8 7 3.1 CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL412830 211283 0 None - 0 Golden hamster 6.4 pKd = 6.4 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL263743 208843 0 None - 0 Rat 5.4 pKd = 5.4 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None None 10.1021/jm00014a022
CHEMBL441181 212133 0 None - 0 Rabbit 5.3 pKd = 5.3 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
9829402 167935 0 None - 0 Rabbit 8.3 pKd = 8.3 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(01)00841-1
CHEMBL435324 167935 0 None - 0 Rabbit 8.3 pKd = 8.3 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(01)00841-1
1488931 51285 13 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
Compound was evaluated for NK-2 receptor antagonistic activity in the guinea pig tracheaCompound was evaluated for NK-2 receptor antagonistic activity in the guinea pig trachea
ChEMBL 344 2 0 6 3.8 O=c1c2cnn(-c3ccccc3)c2nc2scc(-c3ccccc3)n12 10.1016/0960-894X(95)00558-B
CHEMBL158318 51285 13 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
Compound was evaluated for NK-2 receptor antagonistic activity in the guinea pig tracheaCompound was evaluated for NK-2 receptor antagonistic activity in the guinea pig trachea
ChEMBL 344 2 0 6 3.8 O=c1c2cnn(-c3ccccc3)c2nc2scc(-c3ccccc3)n12 10.1016/0960-894X(95)00558-B
9896563 103304 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL308891 103304 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
9939307 201793 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66106 201793 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307757 201842 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 201842 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307758 201862 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 201862 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9810835 201881 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66763 201881 0 None - 0 Guinea pig 7.3 pKd = 7.3 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307741 202090 0 None - 0 Guinea pig 6.3 pKd = 6.3 Functional
In vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstrictionIn vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68234 202090 0 None - 0 Guinea pig 6.3 pKd = 6.3 Functional
In vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstrictionIn vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
104943 55099 34 None - 4 Rabbit 4.3 pKd = 4.3 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55099 34 None - 4 Rabbit 4.3 pKd = 4.3 Functional
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
44347001 112685 0 None - 0 Rabbit 7.3 pKd = 7.3 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 851 15 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL331480 112685 0 None - 0 Rabbit 7.3 pKd = 7.3 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 851 15 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
9939040 4941 5 None - 2 Guinea pig 7.3 pKd = 7.3 Functional
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 4941 5 None - 2 Guinea pig 7.3 pKd = 7.3 Functional
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL266526 208941 0 None - 0 Golden hamster 6.3 pKd = 6.3 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL327457 209547 0 None - 0 Rabbit 5.2 pKd = 5.2 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL334721 209653 1 None - 2 Rat 8.2 pKd = 8.2 Functional
Compound was evaluated for antagonistic activity towards Tachykinin receptor 2 in rat vas deferensCompound was evaluated for antagonistic activity towards Tachykinin receptor 2 in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00282-0
44374504 54564 0 None - 0 Rabbit 8.2 pKd = 8.2 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL161288 54564 0 None - 0 Rabbit 8.2 pKd = 8.2 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
71461644 78487 0 None - 0 Rabbit 8.2 pKd = 8.2 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 784 10 10 10 -0.9 O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL2112924 78487 0 None - 0 Rabbit 8.2 pKd = 8.2 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 784 10 10 10 -0.9 O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O 10.1016/s0960-894x(01)00841-1
11038500 63222 0 None - 1 Rabbit 8.2 pKd = 8.2 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL180049 63222 0 None - 1 Rabbit 8.2 pKd = 8.2 Functional
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44347084 113754 0 None - 0 Golden hamster 8.2 pKd = 8.2 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 893 16 9 9 2.8 CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL333027 113754 0 None - 0 Golden hamster 8.2 pKd = 8.2 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 893 16 9 9 2.8 CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
9875181 170777 0 None - 0 Guinea pig 7.2 pKd = 7.2 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL446146 170777 0 None - 0 Guinea pig 7.2 pKd = 7.2 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391132 68024 0 None - 0 Human 6.2 pKd = 6.2 Functional
Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916634 68024 0 None - 0 Human 6.2 pKd = 6.2 Functional
Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
44307953 168628 0 None - 0 Guinea pig 6.2 pKd = 6.2 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL440679 168628 0 None - 0 Guinea pig 6.2 pKd = 6.2 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL540651 168628 0 None - 0 Guinea pig 6.2 pKd = 6.2 Functional
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL438716 212040 0 None - 0 Golden hamster 5.2 pKd = 5.2 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL216897 207599 0 None - 0 Rabbit 5.2 pKd = 5.2 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
132837 2207 51 None - 4 Rabbit 5.2 pKd = 5.2 Functional
Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
9461 2207 51 None - 4 Rabbit 5.2 pKd = 5.2 Functional
Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
CHEMBL22870 2207 51 None - 4 Rabbit 5.2 pKd = 5.2 Functional
Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
CHEMBL407328 210907 0 None - 0 Rabbit 7.2 pKd = 7.2 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL263997 208856 0 None - 0 Golden hamster 6.2 pKd = 6.2 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL441181 212133 0 None - 0 Golden hamster 5.2 pKd = 5.2 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44346487 113631 0 None - 0 Golden hamster 7.2 pKd = 7.2 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 746 11 9 8 0.2 CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL332872 113631 0 None - 0 Golden hamster 7.2 pKd = 7.2 Functional
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 746 11 9 8 0.2 CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346706 167606 0 None - 0 Rabbit 6.2 pKd = 6.2 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 745 11 9 8 -0.4 CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL433192 167606 0 None - 0 Rabbit 6.2 pKd = 6.2 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 745 11 9 8 -0.4 CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44374622 119558 0 None - 0 Rabbit 8.1 pKd = 8.1 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL350596 119558 0 None - 0 Rabbit 8.1 pKd = 8.1 Functional
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL327457 209547 0 None - 0 Rat 5.1 pKd = 5.1 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL385603 210610 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44347002 112336 0 None - 0 Rabbit 7.1 pKd = 7.1 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 778 11 8 7 1.9 CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL330810 112336 0 None - 0 Rabbit 7.1 pKd = 7.1 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 778 11 8 7 1.9 CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346881 140991 0 None - 0 Rabbit 5.1 pKd = 5.1 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 923 13 9 9 1.5 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O 10.1021/jm00047a020
CHEMBL384610 140991 0 None - 0 Rabbit 5.1 pKd = 5.1 Functional
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 923 13 9 9 1.5 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O 10.1021/jm00047a020
CHEMBL406487 210863 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL387199 210660 0 None - 0 Rabbit 7.1 pKd = 7.1 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
CHEMBL327457 209547 0 None - 0 Golden hamster 5.0 pKd = 5.0 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL412189 211228 0 None - 0 Golden hamster 6.0 pKd = 6.0 Functional
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
CHEMBL413730 211337 0 None - 0 Rat 5.0 pKd = 5.0 Functional
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None None 10.1021/jm00014a022
44434204 153034 0 None - 0 Guinea pig 7.0 pKi = 7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 610 11 3 6 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL398028 153034 0 None - 0 Guinea pig 7.0 pKi = 7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 610 11 3 6 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
10166998 166128 0 None - 0 Guinea pig 7.0 pKi = 7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL428203 166128 0 None - 0 Guinea pig 7.0 pKi = 7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434205 88972 0 None - 0 Guinea pig 6.9 pKi = 6.9 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 623 11 3 6 3.7 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL237048 88972 0 None - 0 Guinea pig 6.9 pKi = 6.9 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 623 11 3 6 3.7 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1 10.1016/j.bmcl.2007.06.053
44434197 148694 0 None - 0 Guinea pig 7.7 pKi = 7.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394419 148694 0 None - 0 Guinea pig 7.7 pKi = 7.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
10121831 89009 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL237097 89009 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434203 148695 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 594 11 3 5 4.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394420 148695 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 594 11 3 5 4.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434191 149304 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL394889 149304 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434202 151638 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 652 17 3 5 6.3 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL396827 151638 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 652 17 3 5 6.3 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
10281234 91802 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL242631 91802 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434198 149291 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 623 11 3 6 4.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL394878 149291 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 623 11 3 6 4.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1 10.1016/j.bmcl.2007.06.053
3881 1824 0 None - 1 Rat 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1331460
2091 2755 0 None 223 2 Guinea pig 8.8 pEC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311427
2089 2725 21 None -1 8 Guinea pig 8.9 pEC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2426129
3795 2725 21 None -1 8 Guinea pig 8.9 pEC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2426129
5311311 2725 21 None -1 8 Guinea pig 8.9 pEC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2426129
CHEMBL217406 2725 21 None -1 8 Guinea pig 8.9 pEC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2426129
16132172 2752 0 None - 1 Guinea pig 9.5 pEC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311427
3667 2752 0 None - 1 Guinea pig 9.5 pEC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311427
30699 215969 0 None -1 14 Human 8.3 pIC50 = 8.3 Functional
NoneNone
Drug Central 423 7 2 8 0.5 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O None
104974 3419 27 None 6 5 Guinea pig 10.3 pIC50 = 10.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
2111 3419 27 None 6 5 Guinea pig 10.3 pIC50 = 10.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
3481 3419 27 None 6 5 Guinea pig 10.3 pIC50 = 10.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
CHEMBL308148 3419 27 None 6 5 Guinea pig 10.3 pIC50 = 10.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
DB06660 3419 27 None 6 5 Guinea pig 10.3 pIC50 = 10.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
3843 2404 0 None - 1 Rat 9.1 pIC50 = 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9718274


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
124003 2451 17 None - 1 Human 7.1 pEC50 = 7.1 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/np058114h
2116 2451 17 None - 1 Human 7.1 pEC50 = 7.1 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/np058114h
CHEMBL507824 2451 17 None - 1 Human 7.1 pEC50 = 7.1 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/np058114h
CHEMBL334721 209653 1 None - 3 Golden hamster 10.1 pIC50 = 10.1 Binding
Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderTested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladder
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/S0960-894X(96)00570-7
104974 3419 27 None 1 7 Human 9.9 pIC50 = 9.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
2111 3419 27 None 1 7 Human 9.9 pIC50 = 9.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
3481 3419 27 None 1 7 Human 9.9 pIC50 = 9.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
CHEMBL308148 3419 27 None 1 7 Human 9.9 pIC50 = 9.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
DB06660 3419 27 None 1 7 Human 9.9 pIC50 = 9.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
68932311 124273 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642170 124273 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
68870199 124274 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642171 124274 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
68932793 124276 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642173 124276 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
68930433 124269 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642166 124269 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
68928720 124277 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642174 124277 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
68870858 124271 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642168 124271 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
68870105 124267 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642164 124267 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
68932418 124275 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 642 6 1 6 4.1 CN(C(=O)c1ccc(N2CCOCC2)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)C3(O)CC3)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642172 124275 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 642 6 1 6 4.1 CN(C(=O)c1ccc(N2CCOCC2)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)C3(O)CC3)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
68928842 124278 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642175 124278 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
9959481 64888 0 None - 1 Human 9.4 pIC50 = 9.4 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 559 7 0 3 6.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL182600 64888 0 None - 1 Human 9.4 pIC50 = 9.4 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 559 7 0 3 6.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
68869786 124270 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 0 5 4.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(N4CCOCC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642167 124270 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 0 5 4.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(N4CCOCC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
104974 3419 27 None 1 7 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
2111 3419 27 None 1 7 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
3481 3419 27 None 1 7 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL308148 3419 27 None 1 7 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
DB06660 3419 27 None 1 7 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
71699787 124260 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642157 124260 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
693306 159882 50 None - 0 Human 9.3 pIC50 = 9.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 290 6 0 3 4.1 CCOc1cc(C=O)ccc1OCc1ccc(Cl)cc1 nan
CHEMBL4111499 159882 50 None - 0 Human 9.3 pIC50 = 9.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 290 6 0 3 4.1 CCOc1cc(C=O)ccc1OCc1ccc(Cl)cc1 nan
68932391 124268 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642165 124268 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
42611207 124266 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642163 124266 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
10929285 66376 0 None - 2 Human 9.1 pIC50 = 9.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL185572 66376 0 None - 2 Human 9.1 pIC50 = 9.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1016/j.bmcl.2005.05.134
104974 3419 27 None 1 7 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
2111 3419 27 None 1 7 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
3481 3419 27 None 1 7 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
CHEMBL308148 3419 27 None 1 7 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
DB06660 3419 27 None 1 7 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
68932301 124272 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642169 124272 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
2089 2725 21 None - 5 Golden hamster 9.0 pIC50 = 9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
3795 2725 21 None - 5 Golden hamster 9.0 pIC50 = 9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
5311311 2725 21 None - 5 Golden hamster 9.0 pIC50 = 9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
CHEMBL217406 2725 21 None - 5 Golden hamster 9.0 pIC50 = 9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
10033398 116789 0 None - 0 Golden hamster 9.0 pIC50 = 9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 824 27 9 10 -0.0 CCCN(C[C@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a024
CHEMBL339591 116789 0 None - 0 Golden hamster 9.0 pIC50 = 9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 824 27 9 10 -0.0 CCCN(C[C@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a024
44392491 167747 0 None - 1 Human 9.0 pIC50 = 9 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 556 7 1 4 5.2 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL434142 167747 0 None - 1 Human 9.0 pIC50 = 9 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 556 7 1 4 5.2 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
71699790 124263 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642160 124263 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
72548703 161019 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL4128926 161019 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
44392351 66069 0 None - 1 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 620 8 0 5 4.3 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185182 66069 0 None - 1 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 620 8 0 5 4.3 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392439 167811 0 None - 1 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 557 7 1 4 5.2 O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL434548 167811 0 None - 1 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 557 7 1 4 5.2 O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
2089 2725 21 None 102 5 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3795 2725 21 None 102 5 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
5311311 2725 21 None 102 5 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL217406 2725 21 None 102 5 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
71699791 124264 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642161 124264 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
10327914 17907 0 None - 0 Golden hamster 8.0 pIC50 = 8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 782 25 10 10 -1.1 CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL126776 17907 0 None - 0 Golden hamster 8.0 pIC50 = 8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 782 25 10 10 -1.1 CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
44392444 121820 0 None - 1 Human 8.0 pIC50 = 8 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 481 7 0 3 4.8 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL359903 121820 0 None - 1 Human 8.0 pIC50 = 8 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 481 7 0 3 4.8 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
44319321 13592 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194933 13592 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553554 13592 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
73265452 125924 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651890 125924 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
91535935 158073 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay
ChEMBL 532 7 1 4 6.8 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/acsmedchemlett.7b00094
CHEMBL4092276 158073 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay
ChEMBL 532 7 1 4 6.8 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/acsmedchemlett.7b00094
44411742 77900 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
CHEMBL210811 77900 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
2812 4711 96 None -28 34 Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 4711 96 None -28 34 Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
2090 2726 20 None -38 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
5311312 2726 20 None -38 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL437797 2726 20 None -38 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
10010429 18852 0 None - 0 Golden hamster 7.0 pIC50 = 7.0 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 776 26 9 10 -0.6 CCCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL128854 18852 0 None - 0 Golden hamster 7.0 pIC50 = 7.0 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 776 26 9 10 -0.6 CCCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
49863734 15160 0 None -13 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 15160 0 None -13 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL103634 206716 0 None - 1 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
44305248 201198 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62679 201198 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
10485206 117674 0 None - 0 Golden hamster 7.0 pIC50 = 7.0 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 748 25 10 10 -1.3 CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL340880 117674 0 None - 0 Golden hamster 7.0 pIC50 = 7.0 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 748 25 10 10 -1.3 CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
44384901 169337 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
CHEMBL444086 169337 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
44319082 167464 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL432183 167464 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL2372521 208524 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2ccccc21)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
10435115 120286 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 476 7 2 3 5.2 [O-][S+](c1ccccc1)C(c1ccccc1)C1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL355541 120286 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 476 7 2 3 5.2 [O-][S+](c1ccccc1)C(c1ccccc1)C1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00074-9
9940218 117834 1 None - 0 Golden hamster 6.9 pIC50 = 6.9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 734 24 10 10 -1.7 CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL341015 117834 1 None - 0 Golden hamster 6.9 pIC50 = 6.9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 734 24 10 10 -1.7 CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
67232184 125925 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651891 125925 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
44384902 59632 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL173245 59632 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44319222 105663 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313546 105663 0 None - 0 Mouse 7.9 pIC50 = 7.9 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
73265453 125926 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651892 125926 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL2372519 208523 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2cc3ccccc3cc21)C(N)=O 10.1021/jm00037a009
71458131 79274 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2115343 79274 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
71452663 78133 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2112070 78133 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
2750 202363 69 None -2 12 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
CHEMBL7002 202363 69 None -2 12 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
9832198 106273 0 None - 3 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106273 0 None - 3 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384986 129252 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
CHEMBL367528 129252 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
10366515 57274 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 450 6 2 3 4.6 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 10.1016/s0960-894x(01)00074-9
CHEMBL166675 57274 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 450 6 2 3 4.6 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 10.1016/s0960-894x(01)00074-9
CHEMBL2372516 208520 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
137647980 157394 3 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay
ChEMBL 600 7 1 4 7.9 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 10.1021/acsmedchemlett.7b00094
CHEMBL4084542 157394 3 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay
ChEMBL 600 7 1 4 7.9 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 10.1021/acsmedchemlett.7b00094
CHEMBL341065 209893 0 None - 0 Golden hamster 6.9 pIC50 = 6.9 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL449091 212210 0 None - 0 Golden hamster 5.9 pIC50 = 5.9 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44312324 202978 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73896 202978 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44312219 101911 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL303868 101911 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44380176 160962 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 613 10 1 3 7.7 CN(C[C@@H](CCN1CCC(NC(=O)c2ccccc2)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(01)00074-9
CHEMBL412815 160962 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 613 10 1 3 7.7 CN(C[C@@H](CCN1CCC(NC(=O)c2ccccc2)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(01)00074-9
44312056 203016 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL74237 203016 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10349900 106267 0 None - 3 Rat 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106267 0 None - 3 Rat 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
6518171 167733 49 None -4 8 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
CHEMBL434063 167733 49 None -4 8 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
3561 18886 34 None -1 11 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
CHEMBL1289 18886 34 None -1 11 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
2098 3638 31 None - 6 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
36511 3638 31 None - 6 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
3805 3638 31 None - 6 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
3835 3638 31 None - 6 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
CHEMBL235363 3638 31 None - 6 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
11038500 63222 0 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL180049 63222 0 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
10940813 65999 0 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185007 65999 0 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
9914897 178480 0 None - 0 Golden hamster 5.8 pIC50 = 5.8 Binding
Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL47146 178480 0 None - 0 Golden hamster 5.8 pIC50 = 5.8 Binding
Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
9914897 178480 0 None - 0 Golden hamster 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL47146 178480 0 None - 0 Golden hamster 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
148124 205370 82 None - 1 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
CHEMBL3545252 205370 82 None - 1 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
CHEMBL92 205370 82 None - 1 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
44319307 106065 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL314119 106065 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319306 106613 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315923 106613 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44212282 60958 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL176682 60958 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL276294 209083 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)S(C)(=O)=O)C(N)=O 10.1021/jm00037a009
138106918 193814 39 None - 1 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
5311497 193814 39 None - 1 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
CHEMBL553025 193814 39 None - 1 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
6918276 15435 4 None -56 8 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS nan
CHEMBL1221512 15435 4 None -56 8 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS nan
CHEMBL306072 209231 0 None - 0 Golden hamster 5.8 pIC50 = 5.8 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
71456198 78165 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL2112209 78165 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
44351724 19199 0 None - 0 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 818 26 9 10 -0.4 CC(C)CC(=O)N(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL129301 19199 0 None - 0 Golden hamster 6.8 pIC50 = 6.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 818 26 9 10 -0.4 CC(C)CC(=O)N(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL340847 209890 0 None - 0 Golden hamster 5.8 pIC50 = 5.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NCCCC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
44312218 202439 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL70461 202439 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
11057 175575 19 None -1 20 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
3468 175575 19 None -1 20 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL459265 175575 19 None -1 20 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL64894 175575 19 None -1 20 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
44305511 201277 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63014 201277 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
44335354 4865 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
CHEMBL104708 4865 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
10349900 106267 0 None - 3 Human 7.8 pIC50 = 7.8 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106267 0 None - 3 Human 7.8 pIC50 = 7.8 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44319223 106621 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
CHEMBL315982 106621 0 None - 0 Mouse 7.8 pIC50 = 7.8 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
22901331 11876 0 None - 1 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11876 0 None - 1 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11876 0 None - 1 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11876 0 None - 1 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11876 0 None - 1 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL406812 210874 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
3823 49951 38 None -36 11 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
76973198 49951 38 None -36 11 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
CHEMBL157101 49951 38 None -36 11 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
44444681 93937 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250798 93937 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
15730 70774 73 None -2 10 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
CHEMBL195437 70774 73 None -2 10 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
10258592 98750 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL281481 98750 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
2090 2726 20 None - 4 Golden hamster 7.8 pIC50 = 7.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
5311312 2726 20 None - 4 Golden hamster 7.8 pIC50 = 7.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
CHEMBL437797 2726 20 None - 4 Golden hamster 7.8 pIC50 = 7.8 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
15391369 102355 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL305509 102355 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
49863732 15158 0 None -24 4 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 15158 0 None -24 4 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
9874168 203991 3 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL82386 203991 3 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL2372525 208525 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
71452678 78167 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2112211 78167 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
10350454 106249 0 None - 3 Rat 6.7 pIC50 = 6.7 Binding
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106249 0 None - 3 Rat 6.7 pIC50 = 6.7 Binding
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384987 61025 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL176769 61025 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44335466 4985 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL105295 4985 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
44319057 204129 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL83585 204129 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL415600 211446 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
2335 11743 21 None -3 12 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
8478 11743 21 None -3 12 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL1182210 11743 21 None -3 12 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL221753 11743 21 None -3 12 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
10395276 18731 0 None - 0 Golden hamster 6.7 pIC50 = 6.7 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 748 24 9 10 -1.4 CC(C)C[C@@H](CN(C)[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL128521 18731 0 None - 0 Golden hamster 6.7 pIC50 = 6.7 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 748 24 9 10 -1.4 CC(C)C[C@@H](CN(C)[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
176 394 63 None -4 31 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157 394 63 None -4 31 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2566 394 63 None -4 31 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
CHEMBL633 394 63 None -4 31 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
DB01118 394 63 None -4 31 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
3191 102385 93 None -12 25 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
CHEMBL305660 102385 93 None -12 25 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
CHEMBL36402 210174 0 None - 0 Golden hamster 4.7 pIC50 = 4.7 Binding
Binding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligandBinding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligand
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O 10.1016/0960-894X(95)00254-Q
73265451 125923 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651889 125923 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
71699789 124262 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642159 124262 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
9853506 12978 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1190281 12978 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL540553 12978 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319086 13600 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194977 13600 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553617 13600 0 None - 0 Mouse 8.7 pIC50 = 8.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
9852376 98645 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL280789 98645 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
71699792 124265 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3642162 124265 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
44404006 132235 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
CHEMBL370013 132235 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
71699788 124261 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642158 124261 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
73265455 125928 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651894 125928 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
3570748 57215 23 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 414 7 1 3 4.1 COC1(C[S+]([O-])c2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL166161 57215 23 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 414 7 1 3 4.1 COC1(C[S+]([O-])c2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL2390989 208666 13 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to human NK2 receptor by radioligand displacement assayBinding affinity to human NK2 receptor by radioligand displacement assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.bmc.2013.03.016
44276792 98674 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL281019 98674 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44392445 66023 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 495 8 0 3 5.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185133 66023 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 495 8 0 3 5.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1 10.1016/j.bmcl.2005.05.134
2098 3638 31 None - 6 Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
36511 3638 31 None - 6 Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
3805 3638 31 None - 6 Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
3835 3638 31 None - 6 Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
CHEMBL235363 3638 31 None - 6 Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
44335410 4931 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105009 4931 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44276738 96742 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26831 96742 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
9874168 203991 3 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL82386 203991 3 None - 0 Mouse 7.7 pIC50 = 7.7 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44312169 202723 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 492 5 3 2 5.4 O=C(Nc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL72140 202723 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 492 5 3 2 5.4 O=C(Nc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
76287260 125226 16 None - 0 Human 4.7 pIC50 = 4.7 Binding
Displacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting methodDisplacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting method
ChEMBL 440 6 0 7 4.1 CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4OC)c3)cnnc21 10.1021/acs.jmedchem.9b00322
CHEMBL3647536 125226 16 None - 0 Human 4.7 pIC50 = 4.7 Binding
Displacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting methodDisplacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting method
ChEMBL 440 6 0 7 4.1 CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4OC)c3)cnnc21 10.1021/acs.jmedchem.9b00322
44312145 203010 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL74176 203010 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
9843958 199109 1 None - 1 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00074-9
CHEMBL60064 199109 1 None - 1 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00074-9
1212 1632 45 None -389 65 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
204 1632 45 None -389 65 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
3372 1632 45 None -389 65 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
CHEMBL726 1632 45 None -389 65 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
DB00623 1632 45 None -389 65 Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
44319250 106524 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315322 106524 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
10099939 4918 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL104954 4918 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
9830304 106863 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
CHEMBL317632 106863 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
10099939 4918 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL104954 4918 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44312257 102437 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306065 102437 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
25129133 188300 0 None -1122 5 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL507340 188300 0 None -1122 5 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
23653789 3530 19 None 1 2 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
9280 3530 19 None 1 2 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
CHEMBL447955 3530 19 None 1 2 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
DB12973 3530 19 None 1 2 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
10350528 106251 0 None - 3 Rat 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106251 0 None - 3 Rat 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
2098 3638 31 None -457 6 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
36511 3638 31 None -457 6 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3805 3638 31 None -457 6 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3835 3638 31 None -457 6 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL235363 3638 31 None -457 6 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
44379971 58445 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 398 3 2 3 3.5 [O-][S+](C[C@]1(O)CCN2CCc3c([nH]c4ccc(F)cc34)[C@H]2C1)c1ccccc1 10.1016/s0960-894x(01)00074-9
CHEMBL168632 58445 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 398 3 2 3 3.5 [O-][S+](C[C@]1(O)CCN2CCc3c([nH]c4ccc(F)cc34)[C@H]2C1)c1ccccc1 10.1016/s0960-894x(01)00074-9
44312028 102379 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL305609 102379 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44335376 4477 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL102376 4477 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
155565189 174992 0 None 2 4 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 634 7 0 9 6.2 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12 10.1016/j.ejmech.2019.04.064
CHEMBL4579120 174992 0 None 2 4 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 634 7 0 9 6.2 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12 10.1016/j.ejmech.2019.04.064
392622 56019 94 None 2 4 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 nan
CHEMBL163 56019 94 None 2 4 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 nan
28417 39799 48 None -1 12 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
CHEMBL1479 39799 48 None -1 12 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
2600 3720 73 None -6 13 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
2608 3720 73 None -6 13 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
5405 3720 73 None -6 13 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
CHEMBL17157 3720 73 None -6 13 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
DB00342 3720 73 None -6 13 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
9984184 202943 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73618 202943 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL2112246 207489 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
2726 906 64 None -125 72 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
621 906 64 None -125 72 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
83 906 64 None -125 72 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
CHEMBL71 906 64 None -125 72 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
DB00477 906 64 None -125 72 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
10055928 116125 0 None - 0 Golden hamster 6.6 pIC50 = 6.6 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 762 25 9 10 -1.0 CCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL336849 116125 0 None - 0 Golden hamster 6.6 pIC50 = 6.6 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 762 25 9 10 -1.0 CCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
44319249 204352 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
CHEMBL85499 204352 0 None - 0 Mouse 5.6 pIC50 = 5.6 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
9869033 99958 3 None - 0 Bovine 5.6 pIC50 = 5.6 Binding
Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL290364 99958 3 None - 0 Bovine 5.6 pIC50 = 5.6 Binding
Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
71450941 79109 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113739 79109 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
16220269 189068 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Inhibition of neurokinin 2 receptorInhibition of neurokinin 2 receptor
ChEMBL 361 3 1 2 4.4 CC[C@@H]1O[C@](/C=C/C2CC2)(C(F)(F)F)c2c(ccc(F)c2F)NC1=O 10.1073/pnas.0605125104
CHEMBL515170 189068 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Inhibition of neurokinin 2 receptorInhibition of neurokinin 2 receptor
ChEMBL 361 3 1 2 4.4 CC[C@@H]1O[C@](/C=C/C2CC2)(C(F)(F)F)c2c(ccc(F)c2F)NC1=O 10.1073/pnas.0605125104
53232 188040 92 None 1 2 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 nan
CHEMBL503 188040 92 None 1 2 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 nan
CHEMBL2115376 207523 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
CHEMBL2369767 207939 0 None - 0 Golden hamster 5.5 pIC50 = 5.5 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
64143 197186 57 None -1 8 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C nan
CHEMBL584 197186 57 None -1 8 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C nan
2247 502 77 None -44 41 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 502 77 None -44 41 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 502 77 None -44 41 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 502 77 None -44 41 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 502 77 None -44 41 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
9831641 79287 5 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2115415 79287 5 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
44319224 106593 0 None - 0 Mouse 8.5 pIC50 = 8.5 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315814 106593 0 None - 0 Mouse 8.5 pIC50 = 8.5 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44392392 129651 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 555 7 0 4 5.4 O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL367815 129651 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 555 7 0 4 5.4 O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
127032997 138003 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells
ChEMBL 748 24 10 10 -2.1 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.bmc.2016.03.006
CHEMBL3775108 138003 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells
ChEMBL 748 24 10 10 -2.1 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.bmc.2016.03.006
CHEMBL2390989 208666 13 None - 1 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.bmc.2016.11.014
137633652 156055 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 749 24 10 10 -1.5 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/acs.jmedchem.6b01422
CHEMBL4068783 156055 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 749 24 10 10 -1.5 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/acs.jmedchem.6b01422
2090 2726 20 None - 4 Golden hamster 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL None None None None 10.1021/jm950892r
5311312 2726 20 None - 4 Golden hamster 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL None None None None 10.1021/jm950892r
CHEMBL437797 2726 20 None - 4 Golden hamster 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL None None None None 10.1021/jm950892r
44319308 105897 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313931 105897 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
15485361 96781 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL26860 96781 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
9915372 126538 1 None -1 2 Human 8.4 pIC50 = 8.4 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL365613 126538 1 None -1 2 Human 8.4 pIC50 = 8.4 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44305557 201125 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL62341 201125 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
44305557 201125 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL62341 201125 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL431641 211878 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
71458099 79181 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2114398 79181 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
155558726 174236 0 None -3 4 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 835 11 0 13 6.7 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C 10.1016/j.ejmech.2019.04.064
CHEMBL4562303 174236 0 None -3 4 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 835 11 0 13 6.7 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C 10.1016/j.ejmech.2019.04.064
5353853 17803 41 None -14 15 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
9556529 17803 41 None -14 15 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1262 17803 41 None -14 15 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
44301871 100280 4 None - 1 Golden hamster 5.5 pIC50 = 5.5 Binding
Concentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladderConcentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladder
ChEMBL 441 9 3 3 4.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL292766 100280 4 None - 1 Golden hamster 5.5 pIC50 = 5.5 Binding
Concentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladderConcentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladder
ChEMBL 441 9 3 3 4.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL311405 209353 15 None - 0 Golden hamster 5.5 pIC50 = 5.5 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44212284 59673 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
CHEMBL173420 59673 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
CHEMBL102128 206712 0 None - 1 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
23294214 168594 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL440465 168594 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL406442 210861 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
1016 3690 75 None -16 35 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 3690 75 None -16 35 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 3690 75 None -16 35 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 3690 75 None -16 35 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 3690 75 None -16 35 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 3690 75 None -16 35 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL103939 206718 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
CHEMBL2115375 207522 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
1836 2554 56 None -40 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
3340 2554 56 None -40 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
5281040 2554 56 None -40 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
CHEMBL787 2554 56 None -40 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
DB00471 2554 56 None -40 15 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
9832198 106273 0 None - 3 Rat 6.4 pIC50 = 6.4 Binding
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106273 0 None - 3 Rat 6.4 pIC50 = 6.4 Binding
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10393390 97825 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL27463 97825 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL216813 207596 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
132837 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 2207 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
2351 3234 60 None -13 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
2820 3234 60 None -13 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
5035 3234 60 None -13 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
CHEMBL81 3234 60 None -13 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
DB00481 3234 60 None -13 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
44386230 61034 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
CHEMBL176811 61034 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
44319084 13585 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194867 13585 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553451 13585 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
133 2460 48 None -165 42 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
1723 2460 48 None -165 42 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
28693 2460 48 None -165 42 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL19215 2460 48 None -165 42 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
DB13520 2460 48 None -165 42 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL405209 210802 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
49863731 15157 0 None -5 3 Rat 7.4 pIC50 = 7.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214024 15157 0 None -5 3 Rat 7.4 pIC50 = 7.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
1024 1263 69 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
162639143 1263 69 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
5284373 1263 69 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
760 1263 69 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
CHEMBL160 1263 69 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
DB00091 1263 69 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
3598 187238 73 None -1 7 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
CHEMBL496 187238 73 None -1 7 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
73265454 125927 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651893 125927 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
44384677 130936 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
CHEMBL369174 130936 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
73265449 123893 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3639507 123893 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
44312285 102484 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306400 102484 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
122179477 120960 3 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of NK2 receptor (unknown origin)Inhibition of NK2 receptor (unknown origin)
ChEMBL 525 5 3 9 3.2 CCn1cc([C@@]2(c3nn(C)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1 10.1021/ml500514w
CHEMBL3582336 120960 3 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of NK2 receptor (unknown origin)Inhibition of NK2 receptor (unknown origin)
ChEMBL 525 5 3 9 3.2 CCn1cc([C@@]2(c3nn(C)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1 10.1021/ml500514w
71449072 78168 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
CHEMBL2112212 78168 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
11059058 9996 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2
ChEMBL 429 3 1 7 4.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 10.1021/jm010878g
CHEMBL115444 9996 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2
ChEMBL 429 3 1 7 4.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 10.1021/jm010878g
10350454 106249 0 None - 3 Human 7.4 pIC50 = 7.4 Binding
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106249 0 None - 3 Human 7.4 pIC50 = 7.4 Binding
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44290659 101063 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL298247 101063 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL411230 211127 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44288896 168421 0 None - 0 Bovine 5.4 pIC50 = 5.4 Binding
Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL43912 168421 0 None - 0 Bovine 5.4 pIC50 = 5.4 Binding
Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
44312256 202874 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL73097 202874 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
1752 45504 56 None -1 5 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 220 8 1 1 4.7 CCCCCCCCCc1ccc(O)cc1 nan
CHEMBL153062 45504 56 None -1 5 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 220 8 1 1 4.7 CCCCCCCCCc1ccc(O)cc1 nan
1548953 205945 24 None -7 17 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL954 205945 24 None -7 17 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL1201469 14341 0 None 1 4 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
CHEMBL2112245 207488 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
10350528 106251 0 None - 3 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106251 0 None - 3 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
11951302 104365 0 None - 1 Human 4.3 pIC50 = 4.3 Binding
Antagonist activity at human NK2 receptorAntagonist activity at human NK2 receptor
ChEMBL 404 7 2 5 3.5 COCCOc1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1ccc(Cl)cc1 10.1021/jm4010708
CHEMBL3109772 104365 0 None - 1 Human 4.3 pIC50 = 4.3 Binding
Antagonist activity at human NK2 receptorAntagonist activity at human NK2 receptor
ChEMBL 404 7 2 5 3.5 COCCOc1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1ccc(Cl)cc1 10.1021/jm4010708
2406 99938 84 None -16 12 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
CHEMBL290106 99938 84 None -16 12 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
4189 205195 91 None -18 34 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 205195 91 None -18 34 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 205195 91 None -18 34 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
10439730 106275 0 None - 3 Rat 6.3 pIC50 = 6.3 Binding
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106275 0 None - 3 Rat 6.3 pIC50 = 6.3 Binding
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44402934 70728 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
CHEMBL195222 70728 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
10379 3010 33 None - 1 Human 5.3 pIC50 = 5.3 Binding
Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor
ChEMBL 340 5 1 7 3.3 CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C 10.1021/jm900025h
9884366 3010 33 None - 1 Human 5.3 pIC50 = 5.3 Binding
Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor
ChEMBL 340 5 1 7 3.3 CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C 10.1021/jm900025h
CHEMBL482950 3010 33 None - 1 Human 5.3 pIC50 = 5.3 Binding
Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor
ChEMBL 340 5 1 7 3.3 CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C 10.1021/jm900025h
DB12572 3010 33 None - 1 Human 5.3 pIC50 = 5.3 Binding
Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor
ChEMBL 340 5 1 7 3.3 CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C 10.1021/jm900025h
CHEMBL264341 208869 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C/c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
5318 15400 44 None -1 13 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1200348 15400 44 None -1 13 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1221 15400 44 None -1 13 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
9939040 4941 5 None -2 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL105060 4941 5 None -2 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
44335319 107024 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL318606 107024 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
25109291 190792 9 None -72 8 Human 8.2 pIC50 = 8.2 Binding
Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
CHEMBL519240 190792 9 None -72 8 Human 8.2 pIC50 = 8.2 Binding
Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
10101612 116794 0 None - 0 Golden hamster 7.3 pIC50 = 7.3 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 752 25 10 11 -2.0 CSCC[C@H](NC[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL339615 116794 0 None - 0 Golden hamster 7.3 pIC50 = 7.3 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 752 25 10 11 -2.0 CSCC[C@H](NC[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
44276673 96908 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26951 96908 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
11989776 2664 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of human NK2 receptorInhibition of human NK2 receptor
ChEMBL 569 5 1 6 5.9 COC(=O)N(c1ccccc1)NC(=O)c1c(CN2CCN(CC2)C(C)(C)C)c(nc2c1cccc2F)c1ccccc1 10.1016/j.bmcl.2006.08.085
2130 2664 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of human NK2 receptorInhibition of human NK2 receptor
ChEMBL 569 5 1 6 5.9 COC(=O)N(c1ccccc1)NC(=O)c1c(CN2CCN(CC2)C(C)(C)C)c(nc2c1cccc2F)c1ccccc1 10.1016/j.bmcl.2006.08.085
CHEMBL221445 2664 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of human NK2 receptorInhibition of human NK2 receptor
ChEMBL 569 5 1 6 5.9 COC(=O)N(c1ccccc1)NC(=O)c1c(CN2CCN(CC2)C(C)(C)C)c(nc2c1cccc2F)c1ccccc1 10.1016/j.bmcl.2006.08.085
44305271 101774 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL303119 101774 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
44291515 100669 0 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
CHEMBL295301 100669 0 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
44305544 201385 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63785 201385 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
5362440 9926 58 None - 1 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
CHEMBL115 9926 58 None - 1 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
10907460 9735 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL113956 9735 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL2372444 208500 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44281769 109172 7 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Binding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligandBinding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligand
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00254-Q
CHEMBL32248 109172 7 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Binding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligandBinding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligand
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00254-Q
44345938 11898 0 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderTested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladder
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
CHEMBL118328 11898 0 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderTested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladder
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
44212281 130094 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL368159 130094 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL2114442 207510 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
44190762 176306 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of radioligand from tachykinin NK2 receptorDisplacement of radioligand from tachykinin NK2 receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
CHEMBL461571 176306 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of radioligand from tachykinin NK2 receptorDisplacement of radioligand from tachykinin NK2 receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
44386105 131408 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL369498 131408 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44335360 4796 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL104348 4796 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
10077113 121029 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL35857 121029 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44385575 59484 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL172676 59484 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
44411637 138750 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
CHEMBL379097 138750 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
10076881 162366 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
CHEMBL417407 162366 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
10055770 116973 0 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 734 24 10 10 -1.7 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL339941 116973 0 None - 0 Golden hamster 5.3 pIC50 = 5.3 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 734 24 10 10 -1.7 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL2114443 207511 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
44319355 105043 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL312173 105043 0 None - 0 Mouse 7.2 pIC50 = 7.2 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
71450949 79139 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL2114103 79139 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
11790 99027 94 None -2 4 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 272 1 0 2 4.6 O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 nan
CHEMBL283196 99027 94 None -2 4 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 272 1 0 2 4.6 O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 nan
73265456 125929 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651895 125929 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
71461705 79208 0 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2114963 79208 0 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
9916195 119993 2 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 576 7 1 4 5.0 CN(C)C(=O)NC1(c2ccccc2)CCN(CC[C@@]2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL354422 119993 2 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 576 7 1 4 5.0 CN(C)C(=O)NC1(c2ccccc2)CCN(CC[C@@]2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL126294 206925 17 None - 0 Golden hamster 8.2 pIC50 = 8.2 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
44310284 202672 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 465 7 0 4 3.7 O=C(CC1CC1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL71784 202672 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 465 7 0 4 3.7 O=C(CC1CC1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
44310102 202688 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 418 7 0 2 5.7 CN(CC(CCN1CCCCC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71918 202688 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 418 7 0 2 5.7 CN(CC(CCN1CCCCC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
10950925 129132 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL367348 129132 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44309946 202219 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 434 7 1 3 4.7 CN(CC(CCN1CCC(O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL69065 202219 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 434 7 1 3 4.7 CN(CC(CCN1CCC(O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
23294208 96700 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL26790 96700 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44310237 103307 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 517 7 0 5 4.2 COc1ccccc1C(=O)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL308901 103307 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 517 7 0 5 4.2 COc1ccccc1C(=O)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
44309945 102593 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 500 8 2 4 4.9 CN(CC(CCN1CCC(O)(c2ncc[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL307338 102593 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 500 8 2 4 4.9 CN(CC(CCN1CCC(O)(c2ncc[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310282 202384 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 523 7 0 5 3.7 O=S(=O)(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL70157 202384 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 523 7 0 5 3.7 O=S(=O)(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
10394084 119339 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 618 9 1 5 7.4 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc(C2(C(F)(F)F)N=N2)c1 10.1016/0960-894X(96)00075-3
CHEMBL348599 119339 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 618 9 1 5 7.4 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc(C2(C(F)(F)F)N=N2)c1 10.1016/0960-894X(96)00075-3
44310456 102301 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 485 8 0 5 5.2 CN(CC(CCN1CCC(n2cncn2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL305191 102301 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 485 8 0 5 5.2 CN(CC(CCN1CCC(n2cncn2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310433 202657 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 456 8 0 4 5.0 CN(CC(CCN1CC(n2ccnc2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71704 202657 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 456 8 0 4 5.0 CN(CC(CCN1CC(n2ccnc2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
11498370 100707 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL295615 100707 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
44386231 61051 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
CHEMBL176951 61051 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
44335372 4706 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL103979 4706 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL2372517 208521 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
3198 203802 73 None -21 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 203802 73 None -21 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 203802 73 None -21 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
138106885 166358 71 None -1 4 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
36314 166358 71 None -1 4 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
CHEMBL428647 166358 71 None -1 4 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
44291788 100942 0 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
CHEMBL297327 100942 0 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
44291015 100757 1 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@](C)(Cc1ccccc1)C(=O)NCCCCCCCCO 10.1021/jm950892r
CHEMBL296014 100757 1 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@](C)(Cc1ccccc1)C(=O)NCCCCCCCCO 10.1021/jm950892r
441243 9743 53 None -19 8 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
CHEMBL114 9743 53 None -19 8 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
CHEMBL307433 209234 0 None - 0 Golden hamster 6.2 pIC50 = 6.2 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
10055415 106274 0 None - 3 Human 7.2 pIC50 = 7.2 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106274 0 None - 3 Human 7.2 pIC50 = 7.2 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10055415 106274 0 None - 3 Rat 7.2 pIC50 = 7.2 Binding
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106274 0 None - 3 Rat 7.2 pIC50 = 7.2 Binding
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
2125 2981 2 None - 1 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
5311350 2981 2 None - 1 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
CHEMBL444832 2981 2 None - 1 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
2125 2981 2 None - 1 Golden hamster 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1021/jm950892r
5311350 2981 2 None - 1 Golden hamster 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1021/jm950892r
CHEMBL444832 2981 2 None - 1 Golden hamster 5.2 pIC50 = 5.2 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1021/jm950892r
44335318 5036 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105600 5036 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
49863733 15159 0 None -2 4 Rat 6.2 pIC50 = 6.2 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 15159 0 None -2 4 Rat 6.2 pIC50 = 6.2 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL410808 211096 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
657255 197406 29 None -17 15 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 nan
CHEMBL588119 197406 29 None -17 15 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 nan
CHEMBL405422 210814 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)SC)C(N)=O 10.1021/jm00037a009
3040489 44310 1 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uM
ChEMBL 318 4 1 2 3.8 O=C1CCN(Cc2ccccc2)CC1Cc1c[nH]c2ccccc12 10.1016/0960-894X(94)80030-8
CHEMBL151990 44310 1 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uM
ChEMBL 318 4 1 2 3.8 O=C1CCN(Cc2ccccc2)CC1Cc1c[nH]c2ccccc12 10.1016/0960-894X(94)80030-8
CHEMBL264353 208873 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
44366600 42686 0 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uM
ChEMBL 360 5 1 2 3.8 O=C1CCN(C(=O)CCc2c[nH]c3ccccc23)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
CHEMBL150346 42686 0 None - 0 Golden hamster 5.2 pIC50 = 5.2 Binding
Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uM
ChEMBL 360 5 1 2 3.8 O=C1CCN(C(=O)CCc2c[nH]c3ccccc23)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
135449286 192586 2 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
CHEMBL52330 192586 2 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
44212285 123300 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
CHEMBL362394 123300 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
73265450 125921 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3651887 125921 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
87318292 125931 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651897 125931 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
44310105 202599 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 550 8 1 5 6.6 CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71394 202599 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 550 8 1 5 6.6 CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310432 202650 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 473 6 0 4 3.8 O=C(c1ccccc1)N1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL71644 202650 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 473 6 0 4 3.8 O=C(c1ccccc1)N1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
44310150 102235 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 534 8 1 3 7.0 CN(CC(CCN1CCC(c2nc3ccccc3[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL304807 102235 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 534 8 1 3 7.0 CN(CC(CCN1CCC(c2nc3ccccc3[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310262 202570 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 536 8 1 5 6.2 CN(CC(CCN1CCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71226 202570 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 536 8 1 5 6.2 CN(CC(CCN1CCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310238 202346 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 487 6 0 4 4.2 O=C(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL69889 202346 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 487 6 0 4 4.2 O=C(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
44310165 202196 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 484 8 0 4 5.8 CN(CC(CCN1CCC(n2ccnc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL68917 202196 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 484 8 0 4 5.8 CN(CC(CCN1CCC(n2ccnc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
10005190 202651 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 475 8 0 4 4.3 CN(CC(CCN1CC(N2CCOCC2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71647 202651 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 475 8 0 4 4.3 CN(CC(CCN1CC(N2CCOCC2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44319323 13635 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1195230 13635 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL554092 13635 0 None - 0 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
9807403 66351 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185452 66351 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392347 121614 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 543 7 0 4 5.1 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL359655 121614 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 543 7 0 4 5.1 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
71449143 79110 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113740 79110 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2371928 208409 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CC(=O)NC(=O)N1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2006.07.036
25028925 90934 2 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 90934 2 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2369630 207900 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44212283 59546 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL172915 59546 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
44319356 103892 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL310173 103892 0 None - 0 Mouse 7.1 pIC50 = 7.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
73265457 125930 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651896 125930 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
10439730 106275 0 None - 3 Human 7.1 pIC50 = 7.1 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106275 0 None - 3 Human 7.1 pIC50 = 7.1 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10972666 122431 0 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 465 7 0 4 3.7 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL360721 122431 0 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 465 7 0 4 3.7 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
9915428 173061 2 None - 0 Golden hamster 6.1 pIC50 = 6.1 Binding
Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL45340 173061 2 None - 0 Golden hamster 6.1 pIC50 = 6.1 Binding
Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
9915428 173061 2 None - 0 Golden hamster 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL45340 173061 2 None - 0 Golden hamster 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
44310151 102305 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 534 8 0 4 6.9 CN(CC(CCN1CCC(n2cnc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL305236 102305 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 534 8 0 4 6.9 CN(CC(CCN1CCC(n2cnc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
153996 112171 2 None -3 3 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL330366 112171 2 None -3 3 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL539021 112171 2 None -3 3 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
153996 112171 2 None - 3 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL330366 112171 2 None - 3 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL539021 112171 2 None - 3 Mouse 8.1 pIC50 = 8.1 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44310139 203004 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 564 8 1 5 7.0 CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL74127 203004 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 564 8 1 5 7.0 CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
9831309 134741 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL372587 134741 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
21831101 202124 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 550 8 1 5 6.6 CN(CC(CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL68440 202124 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 550 8 1 5 6.6 CN(CC(CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
18964186 202601 0 None - 3 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71397 202601 0 None - 3 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
9850582 195566 21 None -1 6 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cellsBinding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(03)00343-3
CHEMBL56835 195566 21 None -1 6 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cellsBinding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(03)00343-3
21121353 101003 0 None - 3 Rat 6.1 pIC50 = 6.1 Binding
Tested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101003 0 None - 3 Rat 6.1 pIC50 = 6.1 Binding
Tested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL2369631 207901 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
2683 102415 24 None -398 16 Human 5.1 pIC50 = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL305906 102415 24 None -398 16 Human 5.1 pIC50 = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL334255 102415 24 None -398 16 Human 5.1 pIC50 = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
579 3095 13 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL None None None None 10.1016/j.bmcl.2006.07.036
6918468 3095 13 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL None None None None 10.1016/j.bmcl.2006.07.036
CHEMBL41547 3095 13 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL None None None None 10.1016/j.bmcl.2006.07.036
10259606 117606 0 None - 0 Golden hamster 8.1 pIC50 = 8.1 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 768 24 10 10 -1.5 CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL340743 117606 0 None - 0 Golden hamster 8.1 pIC50 = 8.1 Binding
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 768 24 10 10 -1.5 CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL263852 208848 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)C)C(N)=O 10.1021/jm00037a009
CHEMBL2390989 208666 13 None - 1 Human 8.0 pIC50 = 8.0 Binding
Binding affinity to human NK2 receptor by radioligand displacement assayBinding affinity to human NK2 receptor by radioligand displacement assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.ejmech.2013.01.044
44319340 204197 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL84055 204197 0 None - 0 Mouse 8.0 pIC50 = 8.0 Binding
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44312000 202973 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73839 202973 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL265573 208909 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C\c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
448537 159703 86 None -26 25 Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
CHEMBL411 159703 86 None -26 25 Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
44384678 61042 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
CHEMBL176860 61042 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
21121353 101003 0 None - 3 Human 7.0 pIC50 = 7 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101003 0 None - 3 Human 7.0 pIC50 = 7 Binding
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
44270502 54967 0 None - 1 Rat 9.7 pKd = 9.7 Binding
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL 714 6 8 7 -0.3 CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](C)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
CHEMBL16180 54967 0 None - 1 Rat 9.7 pKd = 9.7 Binding
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL 714 6 8 7 -0.3 CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](C)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
118718707 114881 0 None - 1 Rat 6.0 pKd = 6 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 843 12 8 9 0.3 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3350012 114881 0 None - 1 Rat 6.0 pKd = 6 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 843 12 8 9 0.3 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718415 114852 0 None -2 2 Rat 5.0 pKd = 5 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 820 12 8 10 -0.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349511 114852 0 None -2 2 Rat 5.0 pKd = 5 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 820 12 8 10 -0.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718693 114877 0 None - 1 Rat 5.0 pKd = 5 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 843 12 8 9 0.3 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349994 114877 0 None - 1 Rat 5.0 pKd = 5 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 843 12 8 9 0.3 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718709 114882 0 None - 1 Rat 5.0 pKd = 5 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 726 8 5 7 2.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3350016 114882 0 None - 1 Rat 5.0 pKd = 5 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 726 8 5 7 2.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718515 114861 0 None - 1 Rat 4.9 pKd = 4.9 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 786 12 7 8 1.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349686 114861 0 None - 1 Rat 4.9 pKd = 4.9 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 786 12 7 8 1.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
118718571 114868 0 None - 1 Rat 4.8 pKd = 4.8 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 747 12 6 8 0.7 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349799 114868 0 None - 1 Rat 4.8 pKd = 4.8 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 747 12 6 8 0.7 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349619 209699 0 None - 1 Rat 4.8 pKd = 4.8 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718570 114867 0 None 63 2 Rat 6.7 pKd = 6.7 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 786 12 7 8 1.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349798 114867 0 None 63 2 Rat 6.7 pKd = 6.7 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 786 12 7 8 1.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349990 209718 0 None - 1 Rat 4.7 pKd = 4.7 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718513 114860 0 None - 1 Rat 5.6 pKd = 5.6 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 797 11 6 8 2.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349683 114860 0 None - 1 Rat 5.6 pKd = 5.6 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 797 11 6 8 2.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
118718694 114878 0 None - 1 Rat 4.6 pKd = 4.6 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 804 12 7 9 -0.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349995 114878 0 None - 1 Rat 4.6 pKd = 4.6 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 804 12 7 9 -0.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718517 114863 0 None -1 3 Rat 6.4 pKd = 6.4 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349688 114863 0 None -1 3 Rat 6.4 pKd = 6.4 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
44270503 98323 0 None - 1 Rat 8.3 pKd = 8.3 Binding
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL 908 10 12 13 -2.8 CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](CSCC3O[C@@H](O)C(O)[C@H](O)[C@H]3O)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
CHEMBL278223 98323 0 None - 1 Rat 8.3 pKd = 8.3 Binding
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL 908 10 12 13 -2.8 CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](CSCC3O[C@@H](O)C(O)[C@H](O)[C@H]3O)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
CHEMBL334721 209653 1 None -9 3 Rat 8.2 pKd = 8.2 Binding
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
CHEMBL3349531 209679 0 None - 1 Rat 6.2 pKd = 6.2 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
CHEMBL3349620 209700 8 None 251 3 Rat 8.1 pKd = 8.1 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718516 114862 0 None -79 3 Rat 5.1 pKd = 5.1 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
CHEMBL3349687 114862 0 None -79 3 Rat 5.1 pKd = 5.1 Binding
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
9831504 84612 0 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 696 8 6 6 2.0 O=C1C[C@@H](NC2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224081 84612 0 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 696 8 6 6 2.0 O=C1C[C@@H](NC2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
71449111 78485 0 None 6 2 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112922 78485 0 None 6 2 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44421489 168163 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 742 9 7 7 0.8 NS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL436981 168163 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 742 9 7 7 0.8 NS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11433617 6693 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083850 6693 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
23625329 92387 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 664 11 3 6 5.6 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Cl)cc2s1 10.1021/jm070289w
CHEMBL243711 92387 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 664 11 3 6 5.6 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Cl)cc2s1 10.1021/jm070289w
11593070 92737 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 708 11 3 6 5.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Br)cc2s1 10.1021/jm070289w
CHEMBL244362 92737 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 708 11 3 6 5.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Br)cc2s1 10.1021/jm070289w
23627059 150644 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 698 11 3 6 5.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(C(F)(F)F)cc2s1 10.1021/jm070289w
CHEMBL395972 150644 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 698 11 3 6 5.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(C(F)(F)F)cc2s1 10.1021/jm070289w
11366268 141473 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL387506 141473 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
44421488 168444 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 741 9 6 7 1.6 CS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL439281 168444 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 741 9 6 7 1.6 CS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11527495 1937 15 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 10.1021/jm070289w
2117 1937 15 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 10.1021/jm070289w
CHEMBL266125 1937 15 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 10.1021/jm070289w
DB12042 1937 15 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 10.1021/jm070289w
46889641 6701 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083858 6701 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237033 14083 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 359 7 1 4 1.9 N[C@@H](CCC(=O)N1CCN(CC2CCOCC2)CC1)Cc1ccccc1 10.1021/jm100176s
CHEMBL1083974 14083 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 359 7 1 4 1.9 N[C@@H](CCC(=O)N1CCN(CC2CCOCC2)CC1)Cc1ccccc1 10.1021/jm100176s
CHEMBL1198853 14083 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 359 7 1 4 1.9 N[C@@H](CCC(=O)N1CCN(CC2CCOCC2)CC1)Cc1ccccc1 10.1021/jm100176s
23627061 150649 0 None - 1 Human 10.0 pKi = 10.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 701 14 3 7 5.8 CCN(CC)c1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
CHEMBL395974 150649 0 None - 1 Human 10.0 pKi = 10.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 701 14 3 7 5.8 CCN(CC)c1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
2115 1817 17 None 8 3 Rat 10.0 pKi = 10 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
9953599 1817 17 None 8 3 Rat 10.0 pKi = 10 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL2110370 1817 17 None 8 3 Rat 10.0 pKi = 10 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
10508281 84359 0 None - 1 Human 10.0 pKi = 10 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm0010217
CHEMBL223221 84359 0 None - 1 Human 10.0 pKi = 10 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm0010217
10508281 84359 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm040832y
CHEMBL223221 84359 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm040832y
11239751 84747 0 None 1995 3 Human 10.0 pKi = 10 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL225297 84747 0 None 1995 3 Human 10.0 pKi = 10 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11193639 142524 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 680 8 6 6 3.0 O=C1C[C@@H](NC2CCSCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL389510 142524 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 680 8 6 6 3.0 O=C1C[C@@H](NC2CCSCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11445137 6722 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 11 2 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083879 6722 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 11 2 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
10508281 84359 0 None - 1 Human 10.0 pKi = 10 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm011127h
CHEMBL223221 84359 0 None - 1 Human 10.0 pKi = 10 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm011127h
10122346 91801 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 652 11 3 7 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(c3ccccn3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242626 91801 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 652 11 3 7 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(c3ccccn3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
71452717 78488 0 None 5 2 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 678 7 5 6 1.6 O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112925 78488 0 None 5 2 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 678 7 5 6 1.6 O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
11388737 84604 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 691 7 5 6 1.7 CC(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL224003 84604 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 691 7 5 6 1.7 CC(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11764349 84642 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 721 9 7 7 1.1 O=C1C[C@@H](NC(=O)CN2CCC(O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224374 84642 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 721 9 7 7 1.1 O=C1C[C@@H](NC(=O)CN2CCC(O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46236920 6706 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 629 12 2 5 7.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083863 6706 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 629 12 2 5 7.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237170 6712 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 640 12 2 5 6.7 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccc(F)cc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083869 6712 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 640 12 2 5 6.7 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccc(F)cc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
23626110 149174 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 640 12 4 7 2.0 NS(=O)(=O)N1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1021/jm070289w
CHEMBL394780 149174 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 640 12 4 7 2.0 NS(=O)(=O)N1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1021/jm070289w
23627060 150646 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 660 12 3 7 4.9 COc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
CHEMBL395973 150646 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 660 12 3 7 4.9 COc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
44302816 198681 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 903 20 7 8 2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL59780 198681 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 903 20 7 8 2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
5487475 88963 24 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 903 20 7 8 2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL2370064 88963 24 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 903 20 7 8 2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
9853827 84797 0 None 794 3 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225588 84797 0 None 794 3 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11216552 96514 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 678 8 5 6 2.7 CN(C1CCOCC1)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
CHEMBL266284 96514 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 678 8 5 6 2.7 CN(C1CCOCC1)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
10326920 142467 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL389459 142467 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11411829 142525 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 712 8 6 7 1.7 O=C1C[C@@H](NC2CCS(=O)(=O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL389511 142525 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 712 8 6 7 1.7 O=C1C[C@@H](NC2CCS(=O)(=O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11228042 161187 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 6 6 5 2.8 N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O 10.1021/jm040832y
CHEMBL413715 161187 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 6 6 5 2.8 N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O 10.1021/jm040832y
46237171 6713 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083870 6713 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237301 6716 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 6 6.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccs5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083873 6716 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 6 6.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccs5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237302 6717 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 6 6.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccsc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083874 6717 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 6 6.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccsc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237445 6718 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 612 12 2 6 6.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccoc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083875 6718 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 612 12 2 6 6.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccoc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
10326920 142467 0 None - 1 Human 9.8 pKi = 9.8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL389459 142467 0 None - 1 Human 9.8 pKi = 9.8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
11205343 84606 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 731 8 5 6 3.5 O=C1C[C@@H](N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224009 84606 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 731 8 5 6 3.5 O=C1C[C@@H](N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11285709 84762 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 6 6 5 2.8 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O 10.1021/jm040832y
CHEMBL225392 84762 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 6 6 5 2.8 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O 10.1021/jm040832y
44421490 141809 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 677 8 6 6 2.2 CN1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL388626 141809 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 677 8 6 6 2.2 CN1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11228450 142254 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 733 8 5 7 2.3 O=C1C[C@@H](N2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL389279 142254 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 733 8 5 7 2.3 O=C1C[C@@H](N2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
9831546 203464 0 None 1 3 Human 9.7 pKi = 9.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78284 203464 0 None 1 3 Human 9.7 pKi = 9.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44307820 201940 0 None 1 2 Guinea pig 9.7 pKi = 9.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 201940 0 None 1 2 Guinea pig 9.7 pKi = 9.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
23626743 92142 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 630 11 3 6 4.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243496 92142 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 630 11 3 6 4.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
53318867 58175 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 639 12 3 6 4.5 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1 10.1016/j.bmcl.2011.01.074
CHEMBL1683146 58175 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 639 12 3 6 4.5 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1 10.1016/j.bmcl.2011.01.074
23627058 150642 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 648 11 3 6 5.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(F)cc2s1 10.1021/jm070289w
CHEMBL395971 150642 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 648 11 3 6 5.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(F)cc2s1 10.1021/jm070289w
11205157 84652 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 718 7 5 6 3.2 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224494 84652 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 718 7 5 6 3.2 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11491634 170979 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 822 10 6 8 1.2 O=C1C[C@@H](NC(=O)CN2CCC(N3CC[S+]([O-])CC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL446450 170979 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 822 10 6 8 1.2 O=C1C[C@@H](NC(=O)CN2CCC(N3CC[S+]([O-])CC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46238093 6689 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 634 12 2 6 5.7 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2cc(Cl)ccc2o1 10.1021/jm100176s
CHEMBL1083846 6689 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 634 12 2 6 5.7 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2cc(Cl)ccc2o1 10.1021/jm100176s
46236387 6692 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 12 2 6 5.5 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2s1 10.1021/jm100176s
CHEMBL1083849 6692 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 12 2 6 5.5 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2s1 10.1021/jm100176s
46237038 6709 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083866 6709 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237300 6715 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccncc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083872 6715 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccncc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
10232332 92768 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccc(Cl)cc2s1 10.1021/jm070289w
CHEMBL244566 92768 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccc(Cl)cc2s1 10.1021/jm070289w
44307819 102123 0 None -1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 102123 0 None -1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307677 168698 0 None 1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 168698 0 None 1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307757 201842 0 None -1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 201842 0 None -1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307758 201862 0 None -1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 201862 0 None -1 2 Guinea pig 9.5 pKi = 9.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44383850 59623 0 None - 1 Rat 9.5 pKi = 9.5 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 552 9 0 4 6.8 CC(=O)OC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
CHEMBL173203 59623 0 None - 1 Rat 9.5 pKi = 9.5 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 552 9 0 4 6.8 CC(=O)OC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
44385292 130866 0 None - 1 Rat 9.5 pKi = 9.5 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 572 10 0 5 7.2 CCN(CC(CCN1CCC(OC(C)=O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 10.1016/S0960-894X(00)80694-0
CHEMBL368995 130866 0 None - 1 Rat 9.5 pKi = 9.5 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 572 10 0 5 7.2 CCN(CC(CCN1CCC(OC(C)=O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 10.1016/S0960-894X(00)80694-0
2115 1817 17 None -8 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cellsBinding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
9953599 1817 17 None -8 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cellsBinding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL2110370 1817 17 None -8 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cellsBinding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
44301859 198130 0 None 35481 2 Rat 9.5 pKi = 9.5 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL59413 198130 0 None 35481 2 Rat 9.5 pKi = 9.5 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
44577911 171687 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 12 3 5 5.7 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL447439 171687 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 12 3 5 5.7 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1 10.1016/j.bmcl.2008.06.102
25071640 173827 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1cccc(Cl)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL455238 173827 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1cccc(Cl)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
71449111 78485 0 None 6 2 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112922 78485 0 None 6 2 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
11193706 10415 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 707 9 6 7 1.0 O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL116812 10415 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 707 9 6 7 1.0 O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11251435 84647 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 721 10 7 7 1.1 O=C1C[C@@H](NC(=O)CN2CCC[C@H]2CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224426 84647 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 721 10 7 7 1.1 O=C1C[C@@H](NC(=O)CN2CCC[C@H]2CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11400251 143328 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 739 9 6 7 0.7 O=C1C[C@@H](NC(=O)CN2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL390168 143328 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 739 9 6 7 0.7 O=C1C[C@@H](NC(=O)CN2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46237960 6615 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 610 12 2 5 5.4 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1 10.1021/jm100176s
CHEMBL1083561 6615 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 610 12 2 5 5.4 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1 10.1021/jm100176s
46889640 6698 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 11 2 6 5.9 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083855 6698 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 11 2 6 5.9 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237299 6714 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccnc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083871 6714 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccnc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236394 6720 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 9 4.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5nnn(C)n5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083877 6720 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 9 4.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5nnn(C)n5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236396 6721 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 618 15 2 6 5.8 CCOCCCN1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
CHEMBL1083878 6721 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 618 15 2 6 5.8 CCOCCCN1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
46236516 6790 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 639 12 2 6 4.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084160 6790 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 639 12 2 6 4.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
44577911 171687 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 664 12 3 5 5.7 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1 10.1021/jm100176s
CHEMBL447439 171687 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 664 12 3 5 5.7 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1 10.1021/jm100176s
11193706 10415 0 None - 1 Human 9.5 pKi = 9.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 707 9 6 7 1.0 O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL116812 10415 0 None - 1 Human 9.5 pKi = 9.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 707 9 6 7 1.0 O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
53324157 58180 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 610 12 2 5 5.4 O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2011.01.074
CHEMBL1683151 58180 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 610 12 2 5 5.4 O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2011.01.074
9961315 117421 0 None -2 3 Human 9.5 pKi = 9.5 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
CHEMBL340326 117421 0 None -2 3 Human 9.5 pKi = 9.5 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
23626900 150651 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cccc(Cl)c2s1 10.1021/jm070289w
CHEMBL395975 150651 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cccc(Cl)c2s1 10.1021/jm070289w
44434191 149304 0 None 501 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL394889 149304 0 None 501 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
11274473 84601 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 744 13 11 10 -1.4 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL223993 84601 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 744 13 11 10 -1.4 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
10876489 84780 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 788 10 6 7 2.6 O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225475 84780 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 788 10 6 7 2.6 O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11331994 168456 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 663 7 5 6 1.8 CN1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL439377 168456 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 663 7 5 6 1.8 CN1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
46238232 6691 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 614 12 2 6 5.3 Cc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1 10.1021/jm100176s
CHEMBL1083848 6691 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 614 12 2 6 5.3 Cc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1 10.1021/jm100176s
46236510 6723 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 639 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)c5cccn5C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083880 6723 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 639 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)c5cccn5C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236512 6788 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 645 10 2 6 4.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084158 6788 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 645 10 2 6 4.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
44343142 155318 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 788 10 6 7 2.6 O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL406024 155318 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 788 10 6 7 2.6 O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
2106 3490 3 None -1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
9875034 3490 3 None -1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
CHEMBL77023 3490 3 None -1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
9810544 203084 0 None -1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL74956 203084 0 None -1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
155551678 174859 0 None -1 3 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
CHEMBL4576324 174859 0 None -1 3 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
44307898 199788 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 199788 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307679 201823 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 201823 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
23625950 142349 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 578 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCSCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL389355 142349 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 578 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCSCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
104974 3419 27 None -1 7 Bovine 9.3 pKi = 9.3 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
2111 3419 27 None -1 7 Bovine 9.3 pKi = 9.3 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
3481 3419 27 None -1 7 Bovine 9.3 pKi = 9.3 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
CHEMBL308148 3419 27 None -1 7 Bovine 9.3 pKi = 9.3 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
DB06660 3419 27 None -1 7 Bovine 9.3 pKi = 9.3 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
44315483 96151 0 None -1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL263243 96151 0 None -1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9831707 203318 0 None 1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76965 203318 0 None 1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9853636 203739 0 None -1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL80355 203739 0 None -1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
102023780 120235 0 None -1 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10417302 120235 0 None -1 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380072 120235 0 None -1 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355041 120235 0 None -1 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
104974 3419 27 None 1 7 Human 9.3 pKi = 9.3 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
2111 3419 27 None 1 7 Human 9.3 pKi = 9.3 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
3481 3419 27 None 1 7 Human 9.3 pKi = 9.3 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
CHEMBL308148 3419 27 None 1 7 Human 9.3 pKi = 9.3 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
DB06660 3419 27 None 1 7 Human 9.3 pKi = 9.3 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
104974 3419 27 None -7 7 Rat 9.3 pKi = 9.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
2111 3419 27 None -7 7 Rat 9.3 pKi = 9.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
3481 3419 27 None -7 7 Rat 9.3 pKi = 9.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL308148 3419 27 None -7 7 Rat 9.3 pKi = 9.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
DB06660 3419 27 None -7 7 Rat 9.3 pKi = 9.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
9843958 199109 1 None - 1 Rat 9.3 pKi = 9.3 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL60064 199109 1 None - 1 Rat 9.3 pKi = 9.3 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
44577907 171885 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL447971 171885 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44421494 141476 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 1068 19 17 20 -5.8 O=C1C[C@@H](NC[C@H](O)[C@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL387542 141476 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 1068 19 17 20 -5.8 O=C1C[C@@H](NC[C@H](O)[C@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11468591 143326 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 748 10 7 7 0.9 NC(=O)C1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL390167 143326 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 748 10 7 7 0.9 NC(=O)C1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
46237957 6614 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 636 13 2 5 5.9 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc(-c2ccccc2)cc1 10.1021/jm100176s
CHEMBL1083560 6614 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 636 13 2 5 5.9 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc(-c2ccccc2)cc1 10.1021/jm100176s
46236647 6697 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083854 6697 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236798 6704 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](/C=C/CN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083861 6704 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](/C=C/CN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
11239162 6708 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 645 13 2 6 6.5 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083865 6708 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 645 13 2 6 6.5 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236514 6789 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 681 12 2 7 4.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084159 6789 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 681 12 2 7 4.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236655 6792 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 638 12 2 6 5.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)C(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084162 6792 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 638 12 2 6 5.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)C(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
2110 2922 33 None -1 6 Rat 9.3 pKi = 9.3 Binding
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
219077 2922 33 None -1 6 Rat 9.3 pKi = 9.3 Binding
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
3480 2922 33 None -1 6 Rat 9.3 pKi = 9.3 Binding
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
CHEMBL346178 2922 33 None -1 6 Rat 9.3 pKi = 9.3 Binding
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
DB04872 2922 33 None -1 6 Rat 9.3 pKi = 9.3 Binding
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
23626744 92145 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 616 10 3 6 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243498 92145 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 616 10 3 6 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
2109 4073 3 None -5 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
9852253 4073 3 None -5 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
CHEMBL129683 4073 3 None -5 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
9830361 181044 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 538 7 1 4 7.1 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL47739 181044 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 538 7 1 4 7.1 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
9850582 195566 21 None -1 6 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56835 195566 21 None -1 6 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44307741 202090 0 None -15 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68234 202090 0 None -15 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL334721 209653 1 None 9 3 Human 9.2 pKi = 9.2 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1021/jm0010217
10281234 91802 0 None 38 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL242631 91802 0 None 38 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
71458042 78486 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 692 8 5 6 2.0 O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112923 78486 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 692 8 5 6 2.0 O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44421493 84602 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 906 16 14 15 -3.6 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL223994 84602 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 906 16 14 15 -3.6 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46237825 6613 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 650 13 2 5 6.3 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2)cc1 10.1021/jm100176s
CHEMBL1083559 6613 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 650 13 2 5 6.3 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2)cc1 10.1021/jm100176s
46238229 6690 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 13 2 7 5.0 COc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1 10.1021/jm100176s
CHEMBL1083847 6690 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 13 2 7 5.0 COc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1 10.1021/jm100176s
9874027 6694 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083851 6694 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237037 6707 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 631 12 2 6 6.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083864 6707 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 631 12 2 6 6.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237168 6710 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 609 11 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083867 6710 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 609 11 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46889663 6791 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 611 11 3 6 3.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(N)(=O)=O)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084161 6791 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 611 11 3 6 3.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(N)(=O)=O)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237698 6793 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 624 12 2 6 4.7 CCS(=O)(=O)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
CHEMBL1084163 6793 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 624 12 2 6 4.7 CCS(=O)(=O)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
46238091 6932 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 600 12 2 6 5.0 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2o1 10.1021/jm100176s
CHEMBL1084765 6932 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 600 12 2 6 5.0 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2o1 10.1021/jm100176s
2109 4073 3 None -5 3 Human 9.2 pKi = 9.2 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
9852253 4073 3 None -5 3 Human 9.2 pKi = 9.2 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
CHEMBL129683 4073 3 None -5 3 Human 9.2 pKi = 9.2 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
10281234 91802 0 None 38 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242631 91802 0 None 38 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
9852630 203145 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75598 203145 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9896757 203273 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76580 203273 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9831075 203442 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78132 203442 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380396 57415 0 None -1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166921 57415 0 None -1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9872857 181172 0 None 2 3 Human 9.2 pKi = 9.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 498 7 1 4 6.1 CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1 10.1021/jm000501v
CHEMBL47775 181172 0 None 2 3 Human 9.2 pKi = 9.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 498 7 1 4 6.1 CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1 10.1021/jm000501v
44307773 101890 0 None -17 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL303803 101890 0 None -17 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
2089 2725 21 None 102 5 Human 9.2 pKi = 9.2 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3795 2725 21 None 102 5 Human 9.2 pKi = 9.2 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
5311311 2725 21 None 102 5 Human 9.2 pKi = 9.2 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL217406 2725 21 None 102 5 Human 9.2 pKi = 9.2 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
10303894 85576 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 588 12 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)s1 10.1021/jm070289w
CHEMBL230424 85576 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 588 12 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)s1 10.1021/jm070289w
23626412 148621 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 659 11 3 7 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL394350 148621 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 659 11 3 7 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
10166998 166128 0 None 125 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL428203 166128 0 None 125 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577893 169450 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 13 3 6 4.8 CCSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL444253 169450 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 13 3 6 4.8 CCSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44577903 169478 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL444289 169478 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
11285716 141505 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL387698 141505 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL406287 141505 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46236796 6703 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 11 2 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083860 6703 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 11 2 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237169 6711 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 610 11 2 7 5.4 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ncccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083868 6711 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 610 11 2 7 5.4 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ncccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46889664 6794 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 672 11 2 6 5.1 CC/N=C(\N1CCOCC1)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
CHEMBL1084164 6794 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 672 11 2 6 5.1 CC/N=C(\N1CCOCC1)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
11285716 141505 0 None - 1 Human 9.1 pKi = 9.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL387698 141505 0 None - 1 Human 9.1 pKi = 9.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL406287 141505 0 None - 1 Human 9.1 pKi = 9.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
9810434 103904 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL310273 103904 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
101195489 155080 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9875056 155080 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL404599 155080 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9917970 203245 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76437 203245 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380206 57467 0 None -1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166961 57467 0 None -1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380448 119774 0 None -1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352588 119774 0 None -1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10370066 172209 1 None 1 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 540 7 1 5 5.9 C[C@H](NC(=O)c1c(CN2CCC(N3CCOCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL45129 172209 1 None 1 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 540 7 1 5 5.9 C[C@H](NC(=O)c1c(CN2CCC(N3CCOCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
44307821 101644 0 None -4 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 101644 0 None -4 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 202075 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 202075 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
23626108 78718 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 589 11 4 6 3.9 C[C@H]1CN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)C[C@@H](C)N1 10.1021/jm070289w
CHEMBL2113292 78718 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 589 11 4 6 3.9 C[C@H]1CN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)C[C@@H](C)N1 10.1021/jm070289w
54537190 79233 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 1 3 6.5 CCC(O)(CC)C1CCN(CC[C@H](CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL2115073 79233 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 1 3 6.5 CCC(O)(CC)C1CCN(CC[C@H](CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
23625325 142816 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 630 11 3 6 5.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL389744 142816 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 630 11 3 6 5.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
23626568 91798 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 673 12 3 7 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242619 91798 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 673 12 3 7 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
9961936 102615 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307498 102615 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9961955 172204 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL451235 172204 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337354 5384 0 None 58 2 Human 9.1 pKi = 9.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
CHEMBL107469 5384 0 None 58 2 Human 9.1 pKi = 9.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
44307678 196998 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 196998 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44384522 59762 0 None - 1 Rat 9.1 pKi = 9.1 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 538 10 0 3 7.3 CCOC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
CHEMBL173841 59762 0 None - 1 Rat 9.1 pKi = 9.1 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 538 10 0 3 7.3 CCOC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
44351946 116866 1 None 1778 3 Human 9.0 pKi = 9.0 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL339767 116866 1 None 1778 3 Human 9.0 pKi = 9.0 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
18964186 202601 0 None -3 3 Bovine 9.0 pKi = 9 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/j.bmcl.2004.06.053
CHEMBL71397 202601 0 None -3 3 Bovine 9.0 pKi = 9 Binding
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/j.bmcl.2004.06.053
153996 112171 2 None -3 3 Human 9.0 pKi = 9 Binding
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL330366 112171 2 None -3 3 Human 9.0 pKi = 9 Binding
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL539021 112171 2 None -3 3 Human 9.0 pKi = 9 Binding
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
15508105 203123 0 None 1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75422 203123 0 None 1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10432325 17773 0 None - 1 Rat 9.0 pKi = 9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.6 Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
CHEMBL126050 17773 0 None - 1 Rat 9.0 pKi = 9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.6 Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
44281649 108533 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32124 108533 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281332 112411 0 None 100 2 Human 9.0 pKi = 9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33106 112411 0 None 100 2 Human 9.0 pKi = 9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
5769 3468 3 None 194 2 Human 9.0 pKi = 9 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 10.1021/jm000501v
9806459 3468 3 None 194 2 Human 9.0 pKi = 9 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 10.1021/jm000501v
CHEMBL295770 3468 3 None 194 2 Human 9.0 pKi = 9 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 10.1021/jm000501v
44434198 149291 0 None 25 2 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 623 11 3 6 4.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL394878 149291 0 None 25 2 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 623 11 3 6 4.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1 10.1016/j.bmcl.2007.06.053
44577908 170510 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 13 3 6 4.8 CSc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL445730 170510 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 13 3 6 4.8 CSc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44577898 170736 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1cccc(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL446086 170736 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1cccc(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44577906 172233 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL451374 172233 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
44577900 188298 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1ccccc1Cl)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL507334 188298 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1ccccc1Cl)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
11764212 84708 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224888 84708 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46237296 6695 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CN5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083852 6695 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CN5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236392 6719 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 612 12 3 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5c[nH]cn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083876 6719 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 612 12 3 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5c[nH]cn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
9875181 170777 0 None -7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL446146 170777 0 None -7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9810835 201881 0 None -7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66763 201881 0 None -7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 202075 0 None -1 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 202075 0 None -1 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44385249 60876 0 None - 1 Rat 9.0 pKi = 9 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 516 8 1 4 6.3 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccsc1 10.1016/S0960-894X(00)80694-0
CHEMBL176588 60876 0 None - 1 Rat 9.0 pKi = 9 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 516 8 1 4 6.3 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccsc1 10.1016/S0960-894X(00)80694-0
18964186 202601 0 None -3 3 Rat 9.0 pKi = 9 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL71397 202601 0 None -3 3 Rat 9.0 pKi = 9 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/S0960-894X(00)80694-0
23626413 91800 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 589 10 3 6 3.0 CN1CCN(C(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1021/jm070289w
CHEMBL242625 91800 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 589 10 3 6 3.0 CN1CCN(C(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1021/jm070289w
44315298 102637 0 None -1 3 Human 9.0 pKi = 9.0 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307733 102637 0 None -1 3 Human 9.0 pKi = 9.0 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337208 5168 0 None 38 2 Human 9.0 pKi = 9.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106300 5168 0 None 38 2 Human 9.0 pKi = 9.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337207 7748 0 None 10 2 Human 9.0 pKi = 9.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108955 7748 0 None 10 2 Human 9.0 pKi = 9.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
23626569 148932 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 659 11 3 7 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL394607 148932 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 659 11 3 7 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
9831674 103932 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL310334 103932 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
44315370 203131 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75479 203131 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315297 203159 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL75698 203159 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
44315299 203302 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76823 203302 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10792233 175841 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 526 7 1 4 5.9 CC(C)C(=O)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1 10.1021/jm000501v
CHEMBL45961 175841 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 526 7 1 4 5.9 CC(C)C(=O)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1 10.1021/jm000501v
104974 3419 27 None -3 7 Golden hamster 8.9 pKi = 8.9 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
2111 3419 27 None -3 7 Golden hamster 8.9 pKi = 8.9 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
3481 3419 27 None -3 7 Golden hamster 8.9 pKi = 8.9 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL308148 3419 27 None -3 7 Golden hamster 8.9 pKi = 8.9 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
DB06660 3419 27 None -3 7 Golden hamster 8.9 pKi = 8.9 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
2089 2725 21 None 102 5 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL None None None None 10.1021/jm401823z
3795 2725 21 None 102 5 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL None None None None 10.1021/jm401823z
5311311 2725 21 None 102 5 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL None None None None 10.1021/jm401823z
CHEMBL217406 2725 21 None 102 5 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL None None None None 10.1021/jm401823z
9887650 16472 0 None 1 5 Rat 8.9 pKi = 8.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL124208 16472 0 None 1 5 Rat 8.9 pKi = 8.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
10476440 116501 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 406 5 2 2 3.9 O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL338825 116501 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 406 5 2 2 3.9 O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
10046881 117975 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 405 5 1 2 4.4 O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL341357 117975 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 405 5 1 2 4.4 O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
10121831 89009 0 None 158 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL237097 89009 0 None 158 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434196 148692 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394418 148692 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434203 148695 0 None 158 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394420 148695 0 None 158 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577901 172888 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1ccc(Cl)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL452960 172888 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1ccc(Cl)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44577902 187746 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL500797 187746 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
11480157 168142 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 906 16 14 15 -3.6 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL436804 168142 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 906 16 14 15 -3.6 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46236649 6699 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 12 2 6 6.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083856 6699 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 12 2 6 6.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
44337355 5274 0 None 26 2 Human 8.9 pKi = 8.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106877 5274 0 None 26 2 Human 8.9 pKi = 8.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337174 7801 0 None 11 2 Human 8.9 pKi = 8.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
CHEMBL108997 7801 0 None 11 2 Human 8.9 pKi = 8.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
22861435 168930 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CC/C(=N\O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL443264 168930 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CC/C(=N\O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44302497 161179 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1095 24 8 14 2.9 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL413650 161179 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1095 24 8 14 2.9 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
118724118 115905 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1095 25 8 14 3.3 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL3360196 115905 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1095 25 8 14 3.3 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
23625476 96492 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 655 11 3 7 4.8 N#Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
CHEMBL266108 96492 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 655 11 3 7 4.8 N#Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
44380526 58020 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168272 58020 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
18964216 59577 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 516 8 1 4 6.3 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 10.1016/S0960-894X(00)80694-0
CHEMBL173008 59577 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 516 8 1 4 6.3 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 10.1016/S0960-894X(00)80694-0
44302414 82038 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1110 25 8 14 3.3 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL217548 82038 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1110 25 8 14 3.3 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
190884 115906 8 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1110 26 8 14 3.7 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL3360197 115906 8 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1110 26 8 14 3.7 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
44302394 96802 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1124 26 8 14 3.7 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL268783 96802 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1124 26 8 14 3.7 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
118724119 115907 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1174 30 9 14 4.8 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL3360198 115907 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1174 30 9 14 4.8 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
44315369 102545 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306952 102545 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380091 120209 0 None -2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354772 120209 0 None -2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10744541 100872 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 520 8 1 4 6.6 CC(C)[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL296857 100872 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 520 8 1 4 6.6 CC(C)[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
44385289 61038 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 560 8 1 3 7.4 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc2ccccc12 10.1016/S0960-894X(00)80694-0
CHEMBL176853 61038 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 560 8 1 3 7.4 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc2ccccc12 10.1016/S0960-894X(00)80694-0
10232331 92739 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cc(Cl)ccc2s1 10.1021/jm070289w
CHEMBL244364 92739 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cc(Cl)ccc2s1 10.1021/jm070289w
10342250 16753 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 423 7 2 3 3.7 CC(=O)N(Cc1ccccc1)CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1021/jm00019a006
CHEMBL125310 16753 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 423 7 2 3 3.7 CC(=O)N(Cc1ccccc1)CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1021/jm00019a006
10477484 17091 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 425 5 1 3 4.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc(F)c1 10.1021/jm00019a006
CHEMBL125696 17091 0 None - 1 Rat 8.8 pKi = 8.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 425 5 1 3 4.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc(F)c1 10.1021/jm00019a006
10722305 109830 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 601 6 5 4 2.8 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1 10.1021/jm0010217
CHEMBL323884 109830 0 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 601 6 5 4 2.8 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1 10.1021/jm0010217
44434195 88166 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.6 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
CHEMBL235574 88166 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.6 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
44434202 151638 0 None 125 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.3 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL396827 151638 0 None 125 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.3 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
44577905 171085 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL446604 171085 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44374556 52451 0 None 1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 773 9 5 6 3.7 O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL159449 52451 0 None 1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 773 9 5 6 3.7 O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44374427 54508 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 765 12 6 8 0.9 O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL161242 54508 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 765 12 6 8 0.9 O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
11491576 84474 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 649 7 6 6 1.4 O=C1C[C@@H](N2CCNCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL223644 84474 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 649 7 6 6 1.4 O=C1C[C@@H](N2CCNCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11343418 84648 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 720 9 6 7 0.9 CN1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL224427 84648 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 720 9 6 7 0.9 CN1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
44421491 136746 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 882 13 11 11 -1.5 CC(=O)N[C@H]1[C@H](NC(=O)CCC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)O[C@H](CO)[C@@H](O)[C@@H]1O 10.1021/jm040832y
CHEMBL375213 136746 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 882 13 11 11 -1.5 CC(=O)N[C@H]1[C@H](NC(=O)CCC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)O[C@H](CO)[C@@H](O)[C@@H]1O 10.1021/jm040832y
11479743 141506 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 7 5 5 3.0 O=C1C[C@@H](N2CCCCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL387699 141506 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 7 5 5 3.0 O=C1C[C@@H](N2CCCCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
10303737 85549 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 582 12 3 5 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)cc1 10.1021/jm070289w
CHEMBL230324 85549 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 582 12 3 5 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)cc1 10.1021/jm070289w
118724120 115908 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1181 29 9 15 3.2 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNCC(=O)Nc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL3360199 115908 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1181 29 9 15 3.2 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNCC(=O)Nc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
10722305 109830 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 601 6 5 4 2.8 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1 10.1021/jm011127h
CHEMBL323884 109830 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 601 6 5 4 2.8 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1 10.1021/jm011127h
44343144 163468 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 662 9 7 8 0.8 O=C1C[C@H](NCc2nn[nH]n2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL420859 163468 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 662 9 7 8 0.8 O=C1C[C@H](NCc2nn[nH]n2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
9939307 201793 0 None 2 4 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL66106 201793 0 None 2 4 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10840329 116464 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 546 8 1 4 7.2 CC[C@H](NC(=O)c1c(CN2CCN(C3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL33868 116464 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 546 8 1 4 7.2 CC[C@H](NC(=O)c1c(CN2CCN(C3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
44315390 203333 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL77042 203333 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380062 120251 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355295 120251 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
9850582 195566 21 None -1 6 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56835 195566 21 None -1 6 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44315576 203534 0 None -1 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78851 203534 0 None -1 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
23625179 83117 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 616 10 3 6 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL220365 83117 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 616 10 3 6 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
23625180 92143 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 12 3 6 5.3 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243497 92143 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 12 3 6 5.3 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
9829402 167935 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm0010217
CHEMBL435324 167935 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm0010217
44331128 106773 0 None - 1 Human 8.7 pKi = 8.7 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 814 12 6 9 1.4 CN(C)CCN(C)C(=O)c1nccnc1C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(02)00539-5
CHEMBL316943 106773 0 None - 1 Human 8.7 pKi = 8.7 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 814 12 6 9 1.4 CN(C)CCN(C)C(=O)c1nccnc1C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(02)00539-5
9829402 167935 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(02)00539-5
CHEMBL435324 167935 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(02)00539-5
44434194 88129 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 575 11 3 6 3.4 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL235353 88129 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 575 11 3 6 3.4 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1016/j.bmcl.2007.06.053
44434197 148694 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394419 148694 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434204 153034 0 None 50 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL398028 153034 0 None 50 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577899 172390 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1ccc(F)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL451751 172390 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1ccc(F)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44577904 188116 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL504342 188116 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
9829402 167935 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(01)00841-1
CHEMBL435324 167935 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(01)00841-1
11332007 84657 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 785 14 11 10 -1.3 CC(=O)N[C@@H](CN[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/jm040832y
CHEMBL224532 84657 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 785 14 11 10 -1.3 CC(=O)N[C@@H](CN[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/jm040832y
11377052 137345 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
CHEMBL376141 137345 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
9829402 167935 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
CHEMBL435324 167935 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
46889639 6696 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083853 6696 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237442 6700 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 575 12 3 5 5.9 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CCO)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083857 6700 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 575 12 3 5 5.9 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CCO)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236794 6702 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)CN4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083859 6702 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)CN4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm100176s
46237575 6812 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 560 11 2 5 4.5 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C=O)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084251 6812 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 560 11 2 5 4.5 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C=O)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
9829402 167935 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm011127h
CHEMBL435324 167935 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm011127h
10026337 112337 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 441 5 1 3 5.0 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(Cl)cc1 10.1021/jm00019a006
CHEMBL330826 112337 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 441 5 1 3 5.0 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(Cl)cc1 10.1021/jm00019a006
10251624 117832 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 6 1 3 4.4 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1CCc1ccccc1 10.1021/jm00019a006
CHEMBL341008 117832 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 6 1 3 4.4 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1CCc1ccccc1 10.1021/jm00019a006
10069913 170743 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 406 5 2 3 3.6 O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)NN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL446099 170743 0 None - 1 Rat 8.0 pKi = 8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 406 5 2 3 3.6 O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)NN1Cc1ccccc1 10.1021/jm00019a006
44281753 99356 0 None 9 2 Human 8.0 pKi = 8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285476 99356 0 None 9 2 Human 8.0 pKi = 8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44353078 96145 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 595 7 5 5 2.6 COc1ccc(CC2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)cc1 10.1021/jm0010217
CHEMBL263194 96145 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 595 7 5 5 2.6 COc1ccc(CC2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)cc1 10.1021/jm0010217
10579116 115935 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 579 7 5 4 3.0 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCc2ccccc2)CN1 10.1021/jm0010217
CHEMBL336053 115935 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 579 7 5 4 3.0 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCc2ccccc2)CN1 10.1021/jm0010217
10232566 4154 0 None - 1 Human 8.0 pKi = 8 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 607 12 2 4 6.1 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL100297 4154 0 None - 1 Human 8.0 pKi = 8 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 607 12 2 4 6.1 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44577894 171849 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 616 12 3 5 4.8 CC(C)c1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL447676 171849 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 616 12 3 5 4.8 CC(C)c1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44577889 187672 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 14 3 6 4.5 CCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL499689 187672 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 14 3 6 4.5 CCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
71461644 78487 0 None -1 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 784 10 10 10 -0.9 O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL2112924 78487 0 None -1 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 784 10 10 10 -0.9 O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O 10.1016/s0960-894x(01)00841-1
49863731 15157 0 None -5 3 Rat 8.0 pKi = 8 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214024 15157 0 None -5 3 Rat 8.0 pKi = 8 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
44343084 10397 0 None - 1 Human 8.0 pKi = 8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 581 7 5 4 3.4 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC2=CC=CCC2)C(=O)N[C@H](CCc2ccccc2)CN1 10.1021/jm011127h
CHEMBL116629 10397 0 None - 1 Human 8.0 pKi = 8 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 581 7 5 4 3.4 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC2=CC=CCC2)C(=O)N[C@H](CCc2ccccc2)CN1 10.1021/jm011127h
23625471 143338 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 590 11 2 6 4.2 CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1 10.1021/jm070289w
CHEMBL390174 143338 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 590 11 2 6 4.2 CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1 10.1021/jm070289w
23625784 85836 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 605 11 4 5 4.2 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(Cl)c(Cl)c2)CCCC1 10.1021/jm070289w
CHEMBL231261 85836 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 605 11 4 5 4.2 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(Cl)c(Cl)c2)CCCC1 10.1021/jm070289w
10001491 117549 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccncc1 10.1021/jm00019a006
CHEMBL340405 117549 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccncc1 10.1021/jm00019a006
11743532 117608 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 432 5 1 4 4.2 N#Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
CHEMBL340747 117608 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 432 5 1 4 4.2 N#Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
10407490 167988 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 381 7 3 3 3.5 OC1(CNCc2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1021/jm00019a006
CHEMBL435619 167988 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 381 7 3 3 3.5 OC1(CNCc2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1021/jm00019a006
44391105 65297 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL183414 65297 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44281391 99518 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 688 11 1 5 9.2 CO/N=C(\CO/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286589 99518 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 688 11 1 5 9.2 CO/N=C(\CO/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44434175 88747 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 540 15 4 7 2.2 CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCOCCOCCN 10.1016/j.bmcl.2007.06.053
CHEMBL236659 88747 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 540 15 4 7 2.2 CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCOCCOCCN 10.1016/j.bmcl.2007.06.053
44434178 88880 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 13 3 5 4.9 CCN(CC)CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236873 88880 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 13 3 5 4.9 CCN(CC)CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434182 89004 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 548 12 3 5 4.5 CCN(CC)CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL237081 89004 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 548 12 3 5 4.5 CCN(CC)CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434192 89005 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 589 11 3 6 3.8 CN1CCN(CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL237082 89005 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 589 11 3 6 3.8 CN1CCN(CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1 10.1016/j.bmcl.2007.06.053
44434187 89175 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 10 3 6 3.5 O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL237516 89175 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 10 3 6 3.5 O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434197 148694 0 None 1 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394419 148694 0 None 1 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434179 166500 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 14 4 5 5.1 NCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL428906 166500 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 14 4 5 5.1 NCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44301551 101337 0 None - 1 Rat 6.0 pKi = 6 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 342 8 3 3 3.2 Cc1ccccc1OCC(O)CNCCc1c[nH]c2ccc(F)cc12 10.1016/S0960-894X(01)80541-2
CHEMBL300174 101337 0 None - 1 Rat 6.0 pKi = 6 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 342 8 3 3 3.2 Cc1ccccc1OCC(O)CNCCc1c[nH]c2ccc(F)cc12 10.1016/S0960-894X(01)80541-2
44391061 64526 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL182104 64526 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
23625323 91931 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 522 11 2 6 2.5 CN(CC(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(=O)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243069 91931 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 522 11 2 6 2.5 CN(CC(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(=O)c1cc2ccccc2s1 10.1021/jm070289w
44391019 63549 0 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL180396 63549 0 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
51351496 60284 7 None -18 4 Human 5.0 pKi = 5 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760205 60284 7 None -18 4 Human 5.0 pKi = 5 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
90417914 118360 0 None -3235 5 Human 5.0 pKi = 5 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
CHEMBL3422015 118360 0 None -3235 5 Human 5.0 pKi = 5 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
44434159 145264 0 None - 1 Human 5.0 pKi = 5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
CHEMBL391696 145264 0 None - 1 Human 5.0 pKi = 5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
44392497 64678 0 None - 1 Human 5.0 pKi = 5 Binding
Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor
ChEMBL 535 7 0 3 6.1 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL182317 64678 0 None - 1 Human 5.0 pKi = 5 Binding
Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor
ChEMBL 535 7 0 3 6.1 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
57391133 68025 0 None -1 2 Human 4.0 pKi = 4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 68025 0 None -1 2 Human 4.0 pKi = 4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
2098 3638 31 None -457 6 Human 7.0 pKi = 7.0 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
36511 3638 31 None -457 6 Human 7.0 pKi = 7.0 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3805 3638 31 None -457 6 Human 7.0 pKi = 7.0 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3835 3638 31 None -457 6 Human 7.0 pKi = 7.0 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL235363 3638 31 None -457 6 Human 7.0 pKi = 7.0 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
10232846 113617 0 None -11 2 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL332793 113617 0 None -11 2 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL411905 211215 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)/N=C(/S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)C(N)=O 10.1021/jm00039a012
44380763 119528 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL350360 119528 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
5353853 17803 41 None -14 15 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
9556529 17803 41 None -14 15 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1262 17803 41 None -14 15 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
25221995 195176 0 None -40 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
CHEMBL565894 195176 0 None -40 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
10010096 99428 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285986 99428 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44215303 118457 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342341 118457 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363952 120498 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356508 120498 0 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380069 57312 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166842 57312 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44266459 4454 0 None -91 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 381 5 2 3 5.4 CC[C@@H](NC(=O)c1c(N)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10224 4454 0 None -91 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 381 5 2 3 5.4 CC[C@@H](NC(=O)c1c(N)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44281392 99496 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286433 99496 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281722 110903 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 590 11 1 5 7.8 CO/N=C(\COCc1ccc2ccccc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32717 110903 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 590 11 1 5 7.8 CO/N=C(\COCc1ccc2ccccc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44215305 118749 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343627 118749 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10002284 16701 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.6 Cc1ccccc1CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
CHEMBL125001 16701 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.6 Cc1ccccc1CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
44434168 88325 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 580 15 4 7 3.2 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236250 88325 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 580 15 4 7 3.2 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
90663622 106227 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 614 15 4 7 3.3 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
CHEMBL3143848 106227 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 614 15 4 7 3.3 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
44577891 188091 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 15 3 6 4.9 CCCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL503837 188091 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 15 3 6 4.9 CCCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
23625633 92148 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 599 11 4 5 3.4 O=C(Nc1ccc(Br)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
CHEMBL243502 92148 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 599 11 4 5 3.4 O=C(Nc1ccc(Br)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
44342868 10461 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 680 10 7 6 1.5 O=C(O)CCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
CHEMBL116969 10461 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 680 10 7 6 1.5 O=C(O)CCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
44342903 109819 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 597 7 5 5 3.0 COc1ccc(C[C@@H]2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC3=CC=CCC3)C(=O)N2)cc1 10.1021/jm011127h
CHEMBL323836 109819 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 597 7 5 5 3.0 COc1ccc(C[C@@H]2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC3=CC=CCC3)C(=O)N2)cc1 10.1021/jm011127h
CHEMBL431641 211878 0 None - 1 Human 7.9 pKi = 7.9 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
44390541 63708 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 558 11 3 5 5.3 CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL180725 63708 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 558 11 3 5 5.3 CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44391089 63945 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL180942 63945 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL5092328 213585 3 None 6 4 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis
ChEMBL None None None CCS(=O)(=O)[C@]1(C)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)O4)ccc2F)N=C1N 10.1021/acs.jmedchem.1c00935
8867347 60279 6 None -10 4 Human 4.9 pKi = 4.9 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760200 60279 6 None -10 4 Human 4.9 pKi = 4.9 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
44305793 100378 0 None -5 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL293432 100378 0 None -5 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
6604014 206112 6 None -28 2 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
CHEMBL9643 206112 6 None -28 2 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
5764 3441 35 None -58 2 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm960818o
6604858 3441 35 None -58 2 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm960818o
CHEMBL9843 3441 35 None -58 2 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm960818o
1016 3690 75 None -16 35 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 3690 75 None -16 35 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 3690 75 None -16 35 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 3690 75 None -16 35 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 3690 75 None -16 35 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 3690 75 None -16 35 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
23625473 166222 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 540 11 3 5 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cccc(Cl)c1 10.1021/jm070289w
CHEMBL428394 166222 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 540 11 3 5 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cccc(Cl)c1 10.1021/jm070289w
19610193 106748 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
CHEMBL316740 106748 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
10454808 167985 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 420 5 2 3 3.4 O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)C(=O)N1Cc1ccccc1 10.1021/jm00019a006
CHEMBL435610 167985 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 420 5 2 3 3.4 O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)C(=O)N1Cc1ccccc1 10.1021/jm00019a006
44331223 206650 0 None - 1 Human 6.9 pKi = 6.9 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 706 16 2 8 4.3 O=C(c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL99608 206650 0 None - 1 Human 6.9 pKi = 6.9 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 706 16 2 8 4.3 O=C(c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44434169 88615 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 568 10 4 5 4.8 NCc1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)cc1 10.1016/j.bmcl.2007.06.053
CHEMBL236458 88615 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 568 10 4 5 4.8 NCc1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)cc1 10.1016/j.bmcl.2007.06.053
44434181 88883 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 15 4 5 5.5 NCCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236874 88883 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 15 4 5 5.5 NCCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
10995343 20646 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC(Cc2ccccc2)CN1 10.1021/jm0010217
CHEMBL131024 20646 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC(Cc2ccccc2)CN1 10.1021/jm0010217
10554969 78091 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC[C@H](Cc2ccccc2)N1 10.1021/jm0010217
CHEMBL2111858 78091 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC[C@H](Cc2ccccc2)N1 10.1021/jm0010217
11801084 78373 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@H](Cc2ccccc2)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm0010217
CHEMBL2112669 78373 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@H](Cc2ccccc2)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm0010217
10576528 109996 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 475 4 5 4 0.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm0010217
CHEMBL324804 109996 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 475 4 5 4 0.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm0010217
10576528 109996 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 475 4 5 4 0.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm011127h
CHEMBL324804 109996 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 475 4 5 4 0.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm011127h
71533722 118355 0 None -933 5 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
CHEMBL3422010 118355 0 None -933 5 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
71549769 118363 0 None -3981 5 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
CHEMBL3422018 118363 0 None -3981 5 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
44312761 103102 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 576 12 0 8 6.0 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1 10.1016/s0960-894x(02)00471-7
CHEMBL308613 103102 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 576 12 0 8 6.0 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1 10.1016/s0960-894x(02)00471-7
44312564 202856 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 486 9 1 8 3.8 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2S1 10.1016/s0960-894x(02)00471-7
CHEMBL72979 202856 0 None - 1 Human 4.9 pKi = 4.9 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 486 9 1 8 3.8 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2S1 10.1016/s0960-894x(02)00471-7
1836 2554 56 None -40 15 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
3340 2554 56 None -40 15 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
5281040 2554 56 None -40 15 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
CHEMBL787 2554 56 None -40 15 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
DB00471 2554 56 None -40 15 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
44314834 203439 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78092 203439 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281359 110080 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 546 11 1 5 7.1 CO/N=C(\COCC1CCCCC1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32533 110080 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 546 11 1 5 7.1 CO/N=C(\COCC1CCCCC1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9987474 203125 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75436 203125 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
22405758 195390 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 476 9 1 3 5.7 CCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56739 195390 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 476 9 1 3 5.7 CCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44390601 63944 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 536 11 3 5 4.5 O=C(Nc1ccc(Sc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL180940 63944 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 536 11 3 5 4.5 O=C(Nc1ccc(Sc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44281785 110875 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 652 11 1 5 9.3 CO/N=C(\COCc1cc(C(C)(C)C)cc(C(C)(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32700 110875 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 652 11 1 5 9.3 CO/N=C(\COCc1cc(C(C)(C)C)cc(C(C)(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44282004 121247 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL35891 121247 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
51351504 60285 1 None -34 4 Human 4.9 pKi = 4.9 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760206 60285 1 None -34 4 Human 4.9 pKi = 4.9 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
2351 3234 60 None -13 21 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
2820 3234 60 None -13 21 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
5035 3234 60 None -13 21 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
CHEMBL81 3234 60 None -13 21 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
DB00481 3234 60 None -13 21 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
132837 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 2207 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
133 2460 48 None -165 42 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
1723 2460 48 None -165 42 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
28693 2460 48 None -165 42 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL19215 2460 48 None -165 42 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
DB13520 2460 48 None -165 42 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
44281397 162418 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1ccccc1C)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL417490 162418 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1ccccc1C)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44364001 39664 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147767 39664 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
3598 187238 73 None -1 7 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
CHEMBL496 187238 73 None -1 7 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
1024 1263 69 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
162639143 1263 69 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
5284373 1263 69 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
760 1263 69 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
CHEMBL160 1263 69 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
DB00091 1263 69 None - 1 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
44380732 58683 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL169002 58683 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44337371 5219 0 None -4 2 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106572 5219 0 None -4 2 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44337288 7963 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109092 7963 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44281345 109991 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32477 109991 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44215306 36943 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145302 36943 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
23625475 92131 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 632 11 3 5 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(I)cc1 10.1021/jm070289w
CHEMBL243280 92131 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 632 11 3 5 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(I)cc1 10.1021/jm070289w
155565189 174992 0 None 2 4 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 634 7 0 9 6.2 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12 10.1016/j.ejmech.2019.04.064
CHEMBL4579120 174992 0 None 2 4 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 634 7 0 9 6.2 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12 10.1016/j.ejmech.2019.04.064
71533722 118355 0 None -933 5 Human 4.9 pKi = 4.9 Binding
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
CHEMBL3422010 118355 0 None -933 5 Human 4.9 pKi = 4.9 Binding
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
44300668 196148 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 448 8 1 3 4.9 CN(CC(CCN1CCC(CO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
CHEMBL57224 196148 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 448 8 1 3 4.9 CN(CC(CCN1CCC(CO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
CHEMBL102128 206712 0 None - 1 Human 5.9 pKi = 5.9 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
2132 3687 48 None -97 6 Human 6.8 pKi = 6.8 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
5311424 3687 48 None -97 6 Human 6.8 pKi = 6.8 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
CHEMBL10188 3687 48 None -97 6 Human 6.8 pKi = 6.8 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
44363756 39597 0 None -8 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147715 39597 0 None -8 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10691318 167052 3 None -102 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 382 5 2 3 5.5 CC[C@@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL430118 167052 3 None -102 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 382 5 2 3 5.5 CC[C@@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
2132 3687 48 None -97 6 Human 6.8 pKi = 6.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm000501v
5311424 3687 48 None -97 6 Human 6.8 pKi = 6.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm000501v
CHEMBL10188 3687 48 None -97 6 Human 6.8 pKi = 6.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm000501v
44363877 38913 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146947 38913 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44281538 109824 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32385 109824 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363442 37707 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145959 37707 0 None -1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44329517 206536 0 None 36 2 Golden hamster 7.8 pKi = 7.8 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 387 4 1 6 3.1 CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O 10.1016/0960-894X(95)00502-K
CHEMBL98929 206536 0 None 36 2 Golden hamster 7.8 pKi = 7.8 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 387 4 1 6 3.1 CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O 10.1016/0960-894X(95)00502-K
10001490 161394 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccn1 10.1021/jm00019a006
CHEMBL415518 161394 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccn1 10.1021/jm00019a006
44577910 187628 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 606 12 3 6 4.2 O=C(/C=C/c1cccs1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL499153 187628 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 606 12 3 6 4.2 O=C(/C=C/c1cccs1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
2090 2726 20 None -38 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisDisplacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
5311312 2726 20 None -38 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisDisplacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
CHEMBL437797 2726 20 None -38 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisDisplacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
11421866 136690 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm040832y
CHEMBL375053 136690 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm040832y
46236800 6705 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.4 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083862 6705 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.4 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
1752 45504 56 None -1 5 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 220 8 1 1 4.7 CCCCCCCCCc1ccc(O)cc1 nan
CHEMBL153062 45504 56 None -1 5 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 220 8 1 1 4.7 CCCCCCCCCc1ccc(O)cc1 nan
1548953 205945 24 None -7 17 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL954 205945 24 None -7 17 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL1201469 14341 0 None 1 4 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
2406 99938 84 None -16 12 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
CHEMBL290106 99938 84 None -16 12 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
CHEMBL103939 206718 0 None - 1 Human 6.8 pKi = 6.8 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
44281743 99178 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284244 99178 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10471895 117574 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 331 3 1 3 2.8 CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
CHEMBL340548 117574 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 331 3 1 3 2.8 CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
44301858 198404 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 372 5 2 3 3.5 N#Cc1ccc2[nH]cc(CCN3CCC(NC(=O)c4ccccc4)CC3)c2c1 10.1016/S0960-894X(01)80541-2
CHEMBL59594 198404 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 372 5 2 3 3.5 N#Cc1ccc2[nH]cc(CCN3CCC(NC(=O)c4ccccc4)CC3)c2c1 10.1016/S0960-894X(01)80541-2
CHEMBL583102 214004 5 None -5248 2 Human 5.8 pKi = 5.8 Binding
Binding affinity at human NK2 receptorBinding affinity at human NK2 receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O 10.1021/jm2017072
CHEMBL583102 214004 5 None -5248 2 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O 10.1021/jm900948q
11203189 63957 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 520 11 3 5 4.2 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181004 63957 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 520 11 3 5 4.2 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44337353 5355 0 None 9 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL107306 5355 0 None 9 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44363983 17982 0 None -2 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL126970 17982 0 None -2 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363926 38833 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146882 38833 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10010039 39665 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147769 39665 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380457 57808 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167613 57808 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
49863733 15159 0 None -2 4 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 15159 0 None -2 4 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44391130 64604 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 492 10 2 4 3.1 O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1 10.1016/j.bmcl.2004.11.045
CHEMBL182264 64604 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 492 10 2 4 3.1 O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1 10.1016/j.bmcl.2004.11.045
44391136 65773 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL183917 65773 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
73354570 88980 0 None -13 2 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
CHEMBL2370513 88980 0 None -13 2 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
155558726 174236 0 None -3 4 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 835 11 0 13 6.7 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C 10.1016/j.ejmech.2019.04.064
CHEMBL4562303 174236 0 None -3 4 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 835 11 0 13 6.7 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C 10.1016/j.ejmech.2019.04.064
4189 205195 91 None -18 34 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 205195 91 None -18 34 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 205195 91 None -18 34 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
5318 15400 44 None -1 13 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1200348 15400 44 None -1 13 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1221 15400 44 None -1 13 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44281957 99355 0 None -27 2 Human 6.8 pKi = 6.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285475 99355 0 None -27 2 Human 6.8 pKi = 6.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44380290 99628 0 None -21 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL287369 99628 0 None -21 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
15887537 108559 0 None -3 3 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL321270 108559 0 None -3 3 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44281303 100004 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 582 11 1 8 6.2 CO/N=C(\COCc1ccc2nonc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL290786 100004 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 582 11 1 8 6.2 CO/N=C(\COCc1ccc2nonc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314946 203354 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77235 203354 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
5362440 9926 58 None - 1 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
CHEMBL115 9926 58 None - 1 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
44266422 4376 0 None -79 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 423 7 1 3 5.8 CC[C@@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10162 4376 0 None -79 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 423 7 1 3 5.8 CC[C@@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
10812218 171506 0 None -79 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 423 7 1 3 5.8 CC[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL44722 171506 0 None -79 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 423 7 1 3 5.8 CC[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
44337414 9125 0 None -5 2 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110507 9125 0 None -5 2 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
44329163 110961 0 None -2 2 Human 4.8 pKi = 4.8 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 344 3 2 6 2.8 Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL327531 110961 0 None -2 2 Human 4.8 pKi = 4.8 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 344 3 2 6 2.8 Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
22901328 205934 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 420 4 3 6 4.2 CC(C)c1nc2[nH]c(N3CCC(O)CC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL95347 205934 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 420 4 3 6 4.2 CC(C)c1nc2[nH]c(N3CCC(O)CC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44281713 99202 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284396 99202 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9849950 100900 0 None 64 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 458 8 1 4 5.3 CCC(CC)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
CHEMBL297086 100900 0 None 64 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 458 8 1 4 5.3 CCC(CC)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
10189341 10024 0 None -10 2 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL115633 10024 0 None -10 2 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
141952732 119959 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44380527 119959 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
CHEMBL354091 119959 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44380095 120343 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355868 120343 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10390570 16367 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 483 6 1 3 5.9 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(c1ccccc1)c1ccccc1 10.1021/jm00019a006
CHEMBL123731 16367 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 483 6 1 3 5.9 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(c1ccccc1)c1ccccc1 10.1021/jm00019a006
10093650 16624 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.9 CC(c1ccccc1)N1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
CHEMBL124624 16624 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.9 CC(c1ccccc1)N1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
10344101 116341 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 457 5 1 3 5.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc2ccccc2c1 10.1021/jm00019a006
CHEMBL338030 116341 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 457 5 1 3 5.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc2ccccc2c1 10.1021/jm00019a006
11802167 78378 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 633 6 5 4 3.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)CN1 10.1021/jm0010217
CHEMBL2112675 78378 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 633 6 5 4 3.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)CN1 10.1021/jm0010217
44434171 88896 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 614 15 4 7 3.0 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL236890 88896 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 614 15 4 7 3.0 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
44434184 89082 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 11 3 5 4.7 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL237303 89082 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 11 3 5 4.7 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577885 188034 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 13 3 6 4.1 CCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL502914 188034 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 13 3 6 4.1 CCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
54583959 60345 0 None -38 4 Human 4.7 pKi = 4.7 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760339 60345 0 None -38 4 Human 4.7 pKi = 4.7 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
11790 99027 94 None -2 4 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 272 1 0 2 4.6 O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 nan
CHEMBL283196 99027 94 None -2 4 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 272 1 0 2 4.6 O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 nan
118724123 115912 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 954 29 11 16 -1.6 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(N)=O 10.1021/jm401823z
CHEMBL3360202 115912 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 954 29 11 16 -1.6 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(N)=O 10.1021/jm401823z
44363948 36148 0 None -5 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144668 36148 0 None -5 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380795 204412 0 None -7 2 Human 6.7 pKi = 6.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL85980 204412 0 None -7 2 Human 6.7 pKi = 6.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10454135 17789 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccnc1 10.1021/jm00019a006
CHEMBL126158 17789 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccnc1 10.1021/jm00019a006
44380415 119809 0 None -2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352813 119809 0 None -2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44281685 99569 0 None 5 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286901 99569 0 None 5 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281977 108906 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32197 108906 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281976 110085 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32537 110085 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10394882 113313 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33249 113313 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
137633652 156055 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 749 24 10 10 -1.5 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/acs.jmedchem.6b01422
CHEMBL4068783 156055 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 749 24 10 10 -1.5 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/acs.jmedchem.6b01422
9918520 102278 0 None -2 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL305055 102278 0 None -2 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9896563 103304 0 None -5 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL308891 103304 0 None -5 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307953 168628 0 None -35 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL440679 168628 0 None -35 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL540651 168628 0 None -35 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9939307 201793 0 None -6 4 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66106 201793 0 None -6 4 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
52918297 58181 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 611 12 2 6 4.8 O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2cn1 10.1016/j.bmcl.2011.01.074
CHEMBL1683152 58181 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 611 12 2 6 4.8 O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2cn1 10.1016/j.bmcl.2011.01.074
23626111 85719 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 645 12 3 7 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL231173 85719 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 645 12 3 7 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
22405735 78011 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CC/C(=N/O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL2111522 78011 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CC/C(=N/O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
23625785 152138 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 556 11 3 5 3.4 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ccccc2c1 10.1021/jm070289w
CHEMBL397264 152138 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 556 11 3 5 3.4 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ccccc2c1 10.1021/jm070289w
10187380 152137 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 545 11 4 5 2.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2[nH]1 10.1021/jm070289w
CHEMBL397263 152137 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 545 11 4 5 2.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2[nH]1 10.1021/jm070289w
10209751 85578 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 559 11 3 6 2.8 Cn1c(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc2ccccc21 10.1021/jm070289w
CHEMBL230426 85578 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 559 11 3 6 2.8 Cn1c(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc2ccccc21 10.1021/jm070289w
23653789 3530 19 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9280 3530 19 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
CHEMBL447955 3530 19 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
DB12973 3530 19 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9825316 178928 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 456 6 2 4 5.0 C[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL47412 178928 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 456 6 2 4 5.0 C[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
44315267 105026 0 None 40 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312141 105026 0 None 40 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315209 203203 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76093 203203 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9979586 16630 0 None - 1 Rat 8.6 pKi = 8.6 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 4 1 4 4.0 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(=O)c1ccccc1 10.1021/jm00019a006
CHEMBL124648 16630 0 None - 1 Rat 8.6 pKi = 8.6 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 4 1 4 4.0 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(=O)c1ccccc1 10.1021/jm00019a006
44353064 156815 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 960 12 13 13 -3.9 CC(=O)N[C@@H]1[C@@H](CO)[C@H](O)[C@@H](CO)O[C@H]1NC(=O)C[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1021/jm0010217
CHEMBL407782 156815 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 960 12 13 13 -3.9 CC(=O)N[C@@H]1[C@@H](CO)[C@H](O)[C@@H](CO)O[C@H]1NC(=O)C[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1021/jm0010217
44434205 88972 0 None 50 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 623 11 3 6 3.7 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL237048 88972 0 None 50 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 623 11 3 6 3.7 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1 10.1016/j.bmcl.2007.06.053
44374598 118986 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 811 10 10 10 -1.2 CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL345402 118986 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 811 10 10 10 -1.2 CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
9887650 16472 0 None -1 5 Guinea pig 8.6 pKi = 8.6 Binding
The compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig tracheaThe compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig trachea
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL124208 16472 0 None -1 5 Guinea pig 8.6 pKi = 8.6 Binding
The compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig tracheaThe compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig trachea
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
44315572 102508 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306624 102508 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9918479 57307 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166827 57307 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
71461711 79232 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CCC(=NO)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL2115072 79232 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CCC(=NO)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44315231 104920 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL311712 104920 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
10167532 92738 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2c(Cl)cccc2s1 10.1021/jm070289w
CHEMBL244363 92738 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2c(Cl)cccc2s1 10.1021/jm070289w
18393120 5188 0 None 10 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106404 5188 0 None 10 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281415 99234 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 702 12 1 5 9.2 CO/N=C(\COC/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284597 99234 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 702 12 1 5 9.2 CO/N=C(\COC/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281680 118086 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 659 11 1 6 8.2 CO/N=C(\COCc1ccc2ccc(C(F)(F)F)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL34167 118086 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 659 11 1 6 8.2 CO/N=C(\COCc1ccc2ccc(C(F)(F)F)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363909 35671 0 None 5 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144223 35671 0 None 5 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
23625321 91876 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 536 11 3 6 3.0 CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1021/jm070289w
CHEMBL242847 91876 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 536 11 3 6 3.0 CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1021/jm070289w
44390529 63853 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 520 11 3 5 4.2 O=C(Nc1ccc(Oc2cccc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL180877 63853 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 520 11 3 5 4.2 O=C(Nc1ccc(Oc2cccc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390606 63966 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.6 CCc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL181050 63966 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.6 CCc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44390998 65258 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1cccc(Oc2ccccc2)c1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL183232 65258 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1cccc(Oc2ccccc2)c1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390535 122302 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 576 14 3 7 3.9 COc1cc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc(OC)c1 10.1016/j.bmcl.2004.11.045
CHEMBL360546 122302 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 576 14 3 7 3.9 COc1cc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc(OC)c1 10.1016/j.bmcl.2004.11.045
44390588 123189 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 544 12 3 5 5.2 CC(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL362201 123189 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 544 12 3 5 5.2 CC(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44314597 103872 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310019 103872 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44391006 63745 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 485 11 2 4 3.4 O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.11.045
CHEMBL180749 63745 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 485 11 2 4 3.4 O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.11.045
44390987 64113 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 471 10 2 4 3.5 O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2004.11.045
CHEMBL181329 64113 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 471 10 2 4 3.5 O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2004.11.045
44390994 64505 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 438 10 2 4 2.3 CN(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181998 64505 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 438 10 2 4 2.3 CN(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391145 121916 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 492 10 2 4 3.1 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1 10.1016/j.bmcl.2004.11.045
CHEMBL360085 121916 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 492 10 2 4 3.1 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1 10.1016/j.bmcl.2004.11.045
3198 203802 73 None -21 34 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 203802 73 None -21 34 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 203802 73 None -21 34 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44329015 206242 0 None - 1 Golden hamster 4.7 pKi = 4.7 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 384 4 2 6 3.6 O=C(O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
CHEMBL97204 206242 0 None - 1 Golden hamster 4.7 pKi = 4.7 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 384 4 2 6 3.6 O=C(O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
138106885 166358 71 None -1 4 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
36314 166358 71 None -1 4 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
CHEMBL428647 166358 71 None -1 4 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
441243 9743 53 None -19 8 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
CHEMBL114 9743 53 None -19 8 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
44314533 105199 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312539 105199 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314482 103332 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL309087 103332 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44281516 99420 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285929 99420 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281333 112226 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 611 11 1 7 7.6 CO/N=C(\COCc1ccc2sc(C)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33046 112226 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 611 11 1 7 7.6 CO/N=C(\COCc1ccc2sc(C)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314482 103332 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL309087 103332 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10078301 118727 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343447 118727 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314482 103332 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL309087 103332 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314482 103332 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL309087 103332 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10394952 104270 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310703 104270 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10417108 99638 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Tested for binding affinity of compound against Tachykinin receptor 2Tested for binding affinity of compound against Tachykinin receptor 2
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287454 99638 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Tested for binding affinity of compound against Tachykinin receptor 2Tested for binding affinity of compound against Tachykinin receptor 2
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10250427 106950 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 400 4 3 6 4.2 CC(C)c1nc2[nH]c(N3CCC(C)(O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL318198 106950 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 400 4 3 6 4.2 CC(C)c1nc2[nH]c(N3CCC(C)(O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44266599 4578 0 None -97 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 440 8 2 4 5.2 CC[C@@H](NC(=O)c1c(OCC(=O)O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10303 4578 0 None -97 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 440 8 2 4 5.2 CC[C@@H](NC(=O)c1c(OCC(=O)O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44380277 58933 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170325 58933 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314548 102436 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306052 102436 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44337201 108125 0 None -245 3 Human 6.7 pKi = 6.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320548 108125 0 None -245 3 Human 6.7 pKi = 6.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337308 5373 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL107407 5373 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44282003 99649 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287523 99649 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9874473 41564 0 None -16 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41564 0 None -16 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
10600223 178888 0 None -4 3 Human 7.7 pKi = 7.7 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 464 7 2 4 5.2 CC[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL47408 178888 0 None -4 3 Human 7.7 pKi = 7.7 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 464 7 2 4 5.2 CC[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
44329340 206678 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 462 5 3 6 5.3 CC(C)c1nc2[nH]c(N3CCC(O)(c4ccccc4)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL99823 206678 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 462 5 3 6 5.3 CC(C)c1nc2[nH]c(N3CCC(O)(c4ccccc4)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
657255 197406 29 None -17 15 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 nan
CHEMBL588119 197406 29 None -17 15 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 nan
44380092 119855 0 None -12 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353162 119855 0 None -12 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44363436 35487 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144057 35487 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363949 120429 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356105 120429 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
9874473 41564 0 None -16 3 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41564 0 None -16 3 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44383761 129295 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 565 10 1 3 6.4 CC(=O)NCC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
CHEMBL367542 129295 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 565 10 1 3 6.4 CC(=O)NCC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
86274490 159339 0 None -1148 3 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
CHEMBL4106866 159339 0 None -1148 3 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
10044833 106961 0 None -43 2 Human 5.6 pKi = 5.6 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 372 5 2 6 3.5 CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL318254 106961 0 None -43 2 Human 5.6 pKi = 5.6 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 372 5 2 6 3.5 CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44380313 57785 0 None -15 2 Human 6.6 pKi = 6.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167409 57785 0 None -15 2 Human 6.6 pKi = 6.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
1760285 206649 3 None -13 2 Human 6.6 pKi = 6.6 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 366 5 1 2 5.8 CC[C@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
CHEMBL9960 206649 3 None -13 2 Human 6.6 pKi = 6.6 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 366 5 1 2 5.8 CC[C@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
1760287 4231 2 None -2 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 366 5 1 2 5.8 CC[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10079 4231 2 None -2 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 366 5 1 2 5.8 CC[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44380764 120216 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354822 120216 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10395141 203117 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75367 203117 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44302769 161128 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1350 26 11 15 6.5 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)/C(S)=N/c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL413205 161128 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1350 26 11 15 6.5 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)/C(S)=N/c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
23625324 91932 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 11 2 6 3.9 CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
CHEMBL243071 91932 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 11 2 6 3.9 CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
44305818 14626 0 None -630 4 Human 5.6 pKi = 5.6 Binding
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 14626 0 None -630 4 Human 5.6 pKi = 5.6 Binding
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 14626 0 None -630 4 Human 5.6 pKi = 5.6 Binding
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
73350089 88978 0 None -19 2 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
CHEMBL2370510 88978 0 None -19 2 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
44380289 119749 0 None -14 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352364 119749 0 None -14 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44281784 112994 0 None 6 2 Human 7.6 pKi = 7.6 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33198 112994 0 None 6 2 Human 7.6 pKi = 7.6 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44434189 168260 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL437777 168260 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577884 170206 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 604 12 3 6 3.7 COc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL445284 170206 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 604 12 3 6 3.7 COc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
44577896 170344 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 631 14 3 6 4.4 CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1 10.1016/j.bmcl.2008.06.102
CHEMBL445493 170344 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 631 14 3 6 4.4 CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1 10.1016/j.bmcl.2008.06.102
44421492 136748 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 939 14 12 12 -2.4 CC(=O)N[C@@H](CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
CHEMBL375214 136748 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 939 14 12 12 -2.4 CC(=O)N[C@@H](CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
23625786 85550 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 557 11 3 6 2.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ncccc2c1 10.1021/jm070289w
CHEMBL230326 85550 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 557 11 3 6 2.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ncccc2c1 10.1021/jm070289w
44390560 65062 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 570 11 3 5 5.1 O=C(Nc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL182947 65062 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 570 11 3 5 5.1 O=C(Nc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
10077178 102706 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 592 12 0 8 5.0 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
CHEMBL308176 102706 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 592 12 0 8 5.0 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
86274727 160236 0 None -1047 3 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4114280 160236 0 None -1047 3 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
44434177 88748 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 548 13 4 5 4.7 NCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236661 88748 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 548 13 4 5 4.7 NCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44329148 108453 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 359 7 4 6 3.6 CC(C)c1nc2[nH]c(NCCCN)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL321137 108453 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 359 7 4 6 3.6 CC(C)c1nc2[nH]c(NCCCN)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44314298 203432 0 None -4 2 Human 6.6 pKi = 6.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78065 203432 0 None -4 2 Human 6.6 pKi = 6.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44363990 16136 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL122643 16136 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363912 118252 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL341843 118252 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
49863734 15160 0 None -13 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 15160 0 None -13 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44314299 203435 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78070 203435 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
52918298 58179 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 631 14 3 6 4.4 CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1 10.1016/j.bmcl.2011.01.074
CHEMBL1683150 58179 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 631 14 3 6 4.4 CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1 10.1016/j.bmcl.2011.01.074
44314578 203438 0 None -13 2 Human 6.6 pKi = 6.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78091 203438 0 None -13 2 Human 6.6 pKi = 6.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44337289 107552 0 None -3 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL319474 107552 0 None -3 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44363963 120764 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL357853 120764 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44337370 106932 0 None -147 2 Human 6.6 pKi = 6.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL318081 106932 0 None -147 2 Human 6.6 pKi = 6.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL2112592 207496 0 None 1 2 Human 4.6 pKi = 4.6 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
10837820 178655 0 None -38 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 463 7 1 3 6.8 CC[C@H](NC(=O)c1c(CN2CCCCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL47275 178655 0 None -38 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 463 7 1 3 6.8 CC[C@H](NC(=O)c1c(CN2CCCCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
2131 3443 63 None -34 2 Human 6.6 pKi = 6.6 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
6604009 3443 63 None -34 2 Human 6.6 pKi = 6.6 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
CHEMBL10284 3443 63 None -34 2 Human 6.6 pKi = 6.6 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
10619783 4614 0 None -5 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 380 5 1 2 6.1 CC[C@@H](NC(=O)c1c(C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10334 4614 0 None -5 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 380 5 1 2 6.1 CC[C@@H](NC(=O)c1c(C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44337324 6633 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108364 6633 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281771 99179 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284269 99179 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363962 35701 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144249 35701 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
44314871 105213 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312573 105213 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
23625783 92430 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 663 11 4 5 3.5 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(I)cc2)CCCC1 10.1021/jm070289w
CHEMBL243933 92430 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 663 11 4 5 3.5 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(I)cc2)CCCC1 10.1021/jm070289w
86275688 147775 0 None -1071 3 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
CHEMBL3936869 147775 0 None -1071 3 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
44329339 112109 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 406 4 2 6 4.0 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL330220 112109 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 406 4 2 6 4.0 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44281744 112975 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33194 112975 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
2683 102415 24 None -398 16 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL305906 102415 24 None -398 16 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL334255 102415 24 None -398 16 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
4529080 166932 6 None -93 2 Human 5.5 pKi = 5.5 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
CHEMBL429951 166932 6 None -93 2 Human 5.5 pKi = 5.5 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
4529080 166932 6 None -93 2 Human 5.5 pKi = 5.5 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm960818o
CHEMBL429951 166932 6 None -93 2 Human 5.5 pKi = 5.5 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm960818o
44329600 4151 0 None - 1 Golden hamster 4.5 pKi = 4.5 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 340 3 1 5 3.9 Clc1ccc(Nc2nc(N3CCOCC3)nc3ccccc23)cc1 10.1016/0960-894X(95)00502-K
CHEMBL100264 4151 0 None - 1 Golden hamster 4.5 pKi = 4.5 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 340 3 1 5 3.9 Clc1ccc(Nc2nc(N3CCOCC3)nc3ccccc23)cc1 10.1016/0960-894X(95)00502-K
44337173 6611 0 None 30 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108350 6611 0 None 30 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281650 113298 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33243 113298 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44282002 124986 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL36462 124986 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9810288 201996 0 None -8 2 Guinea pig 8.5 pKi = 8.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67508 201996 0 None -8 2 Guinea pig 8.5 pKi = 8.5 Binding
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44315421 105248 0 None -2 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312612 105248 0 None -2 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380090 120208 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354771 120208 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
25109291 190792 9 None -72 8 Human 8.5 pKi = 8.5 Binding
Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
CHEMBL519240 190792 9 None -72 8 Human 8.5 pKi = 8.5 Binding
Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
44577892 171257 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 620 12 3 6 4.4 CSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL446853 171257 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 620 12 3 6 4.4 CSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
11285910 141507 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 727 8 5 7 1.1 CS(=O)(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL387700 141507 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 727 8 5 7 1.1 CS(=O)(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11181079 163007 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
CHEMBL420308 163007 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
11296497 168345 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm040832y
CHEMBL438559 168345 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm040832y
23626109 166137 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 11 4 6 3.6 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(O)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL428217 166137 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 11 4 6 3.6 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(O)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
44342780 109668 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 604 6 6 4 3.0 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)CN1 10.1021/jm011127h
CHEMBL323677 109668 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 604 6 6 4 3.0 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)CN1 10.1021/jm011127h
44343083 109905 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 585 6 5 5 2.6 O=C1CCC(=O)N[C@@H](CC2CNc3ccc(F)cc32)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm011127h
CHEMBL324313 109905 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 585 6 5 5 2.6 O=C1CCC(=O)N[C@@H](CC2CNc3ccc(F)cc32)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm011127h
11181079 163007 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
CHEMBL420308 163007 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
11296497 168345 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm011127h
CHEMBL438559 168345 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm011127h
44380131 57308 0 None -3 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166828 57308 0 None -3 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44337330 5260 0 None 6 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106816 5260 0 None 6 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
53322827 58177 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 657 12 3 6 4.6 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1F 10.1016/j.bmcl.2011.01.074
CHEMBL1683148 58177 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 657 12 3 6 4.6 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1F 10.1016/j.bmcl.2011.01.074
44337266 5226 0 None 27 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106608 5226 0 None 27 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44337313 108116 0 None 7 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320487 108116 0 None 7 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44380132 95980 0 None -4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL262053 95980 0 None -4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9914111 195024 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 1 3 6.5 CCC(O)(CC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56481 195024 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 1 3 6.5 CCC(O)(CC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44315590 167245 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
CHEMBL430609 167245 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
22405764 195473 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 490 10 1 3 6.1 CCCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56788 195473 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 490 10 1 3 6.1 CCCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
23626252 92130 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 12 4 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243278 92130 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 12 4 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
23625637 150393 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 613 11 4 5 3.8 Cc1cc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)ccc1Br 10.1021/jm070289w
CHEMBL395774 150393 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 613 11 4 5 3.8 Cc1cc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)ccc1Br 10.1021/jm070289w
10025437 15465 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 425 5 1 3 4.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1 10.1021/jm00019a006
CHEMBL122169 15465 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 425 5 1 3 4.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1 10.1021/jm00019a006
10048714 16416 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 437 6 1 4 4.3 COc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
CHEMBL124013 16416 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 437 6 1 4 4.3 COc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
44301859 198130 0 None 35481 2 Rat 8.4 pKi = 8.4 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL59413 198130 0 None 35481 2 Rat 8.4 pKi = 8.4 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
10305816 4155 0 None - 1 Human 8.4 pKi = 8.4 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 736 16 2 6 6.9 O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL100298 4155 0 None - 1 Human 8.4 pKi = 8.4 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 736 16 2 6 6.9 O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44434193 88143 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 589 11 3 6 3.8 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL235431 88143 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 589 11 3 6 3.8 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1 10.1016/j.bmcl.2007.06.053
44434185 89083 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 11 3 5 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL237304 89083 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 11 3 5 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577887 169059 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 15 3 6 4.9 CCCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL443691 169059 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 15 3 6 4.9 CCCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
44577897 169367 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1ccccc1F)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL444142 169367 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1ccccc1F)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44577888 173303 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 13 3 6 4.1 CCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL453961 173303 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 13 3 6 4.1 CCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
71449112 78489 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 682 10 8 7 0.3 O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112926 78489 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 682 10 8 7 0.3 O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
53326714 58176 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 673 12 3 6 5.2 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1Cl 10.1016/j.bmcl.2011.01.074
CHEMBL1683147 58176 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 673 12 3 6 5.2 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1Cl 10.1016/j.bmcl.2011.01.074
44421495 84745 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 920 15 14 15 -4.1 O=C1CC(NC(=O)[C@@H](O)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225264 84745 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 920 15 14 15 -4.1 O=C1CC(NC(=O)[C@@H](O)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
10372391 9756 0 None - 1 Human 8.4 pKi = 8.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 679 9 9 6 0.1 N=C(N)NCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
CHEMBL114068 9756 0 None - 1 Human 8.4 pKi = 8.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 679 9 9 6 0.1 N=C(N)NCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
44342904 10426 0 None - 1 Human 8.4 pKi = 8.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 676 9 6 9 0.3 O=C(Cn1cnnn1)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)NC1=O 10.1021/jm011127h
CHEMBL116871 10426 0 None - 1 Human 8.4 pKi = 8.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 676 9 6 9 0.3 O=C(Cn1cnnn1)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)NC1=O 10.1021/jm011127h
44314502 203089 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75018 203089 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
23625326 148847 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1sc2ccccc2c1Cl 10.1021/jm070289w
CHEMBL394543 148847 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1sc2ccccc2c1Cl 10.1021/jm070289w
44391011 64040 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1cccc(Oc2ccccc2)c1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181291 64040 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1cccc(Oc2ccccc2)c1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44337467 109726 0 None -17 2 Human 6.5 pKi = 6.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL323741 109726 0 None -17 2 Human 6.5 pKi = 6.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
44391005 121817 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 438 10 2 4 2.3 CN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL359885 121817 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 438 10 2 4 2.3 CN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391123 121844 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 471 10 2 4 3.5 O=C(N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.11.045
CHEMBL360023 121844 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 471 10 2 4 3.5 O=C(N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.11.045
86275685 144745 0 None -416 2 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)C3C)n1 nan
CHEMBL3913001 144745 0 None -416 2 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)C3C)n1 nan
10022196 206546 0 None -45 2 Human 5.5 pKi = 5.5 Binding
Inhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cellsInhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 372 4 2 6 3.7 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL98977 206546 0 None -45 2 Human 5.5 pKi = 5.5 Binding
Inhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cellsInhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 372 4 2 6 3.7 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44314503 203285 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL76704 203285 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
9931729 100524 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 416 6 2 4 3.2 O=S(=O)(CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL294336 100524 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 416 6 2 4 3.2 O=S(=O)(CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
44301695 199704 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 382 6 2 3 4.1 Cc1ccccc1OCC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/S0960-894X(01)80541-2
CHEMBL60459 199704 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 382 6 2 3 4.1 Cc1ccccc1OCC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/S0960-894X(01)80541-2
10122872 107275 0 None - 1 Human 7.5 pKi = 7.5 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 704 16 2 6 5.5 O=C(c1ccccc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL319154 107275 0 None - 1 Human 7.5 pKi = 7.5 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 704 16 2 6 5.5 O=C(c1ccccc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44434195 88166 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.6 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
CHEMBL235574 88166 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.6 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
44434186 154255 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 12 3 5 5.3 CC(C)N(CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(C)C 10.1016/j.bmcl.2007.06.053
CHEMBL400209 154255 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 12 3 5 5.3 CC(C)N(CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(C)C 10.1016/j.bmcl.2007.06.053
44391033 123041 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL361815 123041 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390451 165632 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 532 12 3 6 4.1 COc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL426421 165632 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 532 12 3 6 4.1 COc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44391026 123394 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL362800 123394 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL2111789 207475 0 None 3 2 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
44266551 97876 0 None -58 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 394 6 1 2 6.3 CCc1c(-c2ccccc2)nc2ccccc2c1C(=O)N[C@H](CC)c1ccccc1 10.1021/jm980633c
CHEMBL275017 97876 0 None -58 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 394 6 1 2 6.3 CCc1c(-c2ccccc2)nc2ccccc2c1C(=O)N[C@H](CC)c1ccccc1 10.1021/jm980633c
10626894 9829 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 571 6 5 4 3.3 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1 10.1021/jm0010217
CHEMBL114442 9829 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 571 6 5 4 3.3 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1 10.1021/jm0010217
44434162 145289 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 489 8 3 4 4.3 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NC2CC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL391710 145289 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 489 8 3 4 4.3 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NC2CC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434163 146327 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 534 11 3 5 4.1 CN(C)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL392523 146327 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 534 11 3 5 4.1 CN(C)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434160 166794 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
CHEMBL429452 166794 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
10626894 9829 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 571 6 5 4 3.3 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1 10.1021/jm011127h
CHEMBL114442 9829 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 571 6 5 4 3.3 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1 10.1021/jm011127h
10985363 10422 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 703 9 5 6 3.6 C=CCOC(=O)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N1 10.1021/jm011127h
CHEMBL116855 10422 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 703 9 5 6 3.6 C=CCOC(=O)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N1 10.1021/jm011127h
10875451 109869 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.6 O=C1CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL324106 109869 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.6 O=C1CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
448537 159703 86 None -26 25 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
CHEMBL411 159703 86 None -26 25 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
44390446 64133 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 550 12 3 5 4.5 O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181359 64133 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 550 12 3 5 4.5 O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
86275451 159546 0 None -4466 3 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL4108623 159546 0 None -4466 3 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
10668461 79053 0 None -181 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 396 6 1 3 5.8 CC[C@H](NC(=O)c1c(OC)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL2113673 79053 0 None -181 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 396 6 1 3 5.8 CC[C@H](NC(=O)c1c(OC)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44363936 19835 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL130354 19835 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10552329 167481 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 470 6 2 4 5.5 C[C@H](NC(=O)c1c(CN2CCC(N)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL432301 167481 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 470 6 2 4 5.5 C[C@H](NC(=O)c1c(CN2CCC(N)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
9874473 41564 0 None -16 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41564 0 None -16 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44314504 102443 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306121 102443 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
22405732 194721 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 462 8 1 3 5.3 CC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56274 194721 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 462 8 1 3 5.3 CC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
11496610 4012 11 None 2 2 Human 6.5 pKi = 6.5 Binding
Inhibition of human neurokinin NK2 receptorInhibition of human neurokinin NK2 receptor
ChEMBL 476 4 1 5 5.8 CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C 10.1021/jm801572m
5582 4012 11 None 2 2 Human 6.5 pKi = 6.5 Binding
Inhibition of human neurokinin NK2 receptorInhibition of human neurokinin NK2 receptor
ChEMBL 476 4 1 5 5.8 CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C 10.1021/jm801572m
CHEMBL474991 4012 11 None 2 2 Human 6.5 pKi = 6.5 Binding
Inhibition of human neurokinin NK2 receptorInhibition of human neurokinin NK2 receptor
ChEMBL 476 4 1 5 5.8 CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C 10.1021/jm801572m
73353047 88976 0 None -1 2 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370509 88976 0 None -1 2 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44281358 97811 0 None -3 2 Human 6.5 pKi = 6.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL274557 97811 0 None -3 2 Human 6.5 pKi = 6.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
2812 4711 96 None -28 34 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 4711 96 None -28 34 Human 5.5 pKi = 5.5 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
44314868 155157 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL405129 155157 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314867 156785 0 None -8 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL407749 156785 0 None -8 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44329374 206545 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 430 6 2 7 4.5 COC1(OC)CCN(c2nc(Nc3ccc(Cl)cc3)c3[nH]c(C(C)C)nc3n2)CC1 10.1016/0960-894X(95)00502-K
CHEMBL98976 206545 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 430 6 2 7 4.5 COC1(OC)CCN(c2nc(Nc3ccc(Cl)cc3)c3[nH]c(C(C)C)nc3n2)CC1 10.1016/0960-894X(95)00502-K
44329484 206229 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 344 6 3 5 4.7 CCCNc1nc(Nc2ccc(Cl)cc2)c2[nH]c(C(C)C)nc2n1 10.1016/0960-894X(95)00502-K
CHEMBL97140 206229 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 344 6 3 5 4.7 CCCNc1nc(Nc2ccc(Cl)cc2)c2[nH]c(C(C)C)nc2n1 10.1016/0960-894X(95)00502-K
44281572 109903 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32431 109903 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9874473 41564 0 None -16 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41564 0 None -16 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
9852904 116536 0 None -128 3 Human 7.5 pKi = 7.5 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
CHEMBL339051 116536 0 None -128 3 Human 7.5 pKi = 7.5 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
2110 2922 33 None -138 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
219077 2922 33 None -138 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
3480 2922 33 None -138 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
CHEMBL346178 2922 33 None -138 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
DB04872 2922 33 None -138 6 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
44380474 58475 0 None -13 2 Human 6.5 pKi = 6.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168769 58475 0 None -13 2 Human 6.5 pKi = 6.5 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314481 203228 0 None -10 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL76334 203228 0 None -10 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
86275686 146633 0 None -851 2 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)C3C)n1 nan
CHEMBL3927872 146633 0 None -851 2 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)C3C)n1 nan
86274728 160409 0 None -1380 2 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 394 2 0 7 2.7 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2)[C@@H]3C)n1 nan
CHEMBL4115594 160409 0 None -1380 2 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 394 2 0 7 2.7 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2)[C@@H]3C)n1 nan
44314865 203403 0 None -3 2 Human 6.4 pKi = 6.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77752 203403 0 None -3 2 Human 6.4 pKi = 6.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
9874473 41564 0 None -16 3 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41564 0 None -16 3 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
2132 3687 48 None -97 6 Human 5.4 pKi = 5.4 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1016/j.bmcl.2011.02.033
5311424 3687 48 None -97 6 Human 5.4 pKi = 5.4 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1016/j.bmcl.2011.02.033
CHEMBL10188 3687 48 None -97 6 Human 5.4 pKi = 5.4 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1016/j.bmcl.2011.02.033
2089 2725 21 None -3548 5 Guinea pig 5.4 pKi = 5.4 Binding
Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor
ChEMBL None None None None 10.1021/jm00073a022
3795 2725 21 None -3548 5 Guinea pig 5.4 pKi = 5.4 Binding
Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor
ChEMBL None None None None 10.1021/jm00073a022
5311311 2725 21 None -3548 5 Guinea pig 5.4 pKi = 5.4 Binding
Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor
ChEMBL None None None None 10.1021/jm00073a022
CHEMBL217406 2725 21 None -3548 5 Guinea pig 5.4 pKi = 5.4 Binding
Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor
ChEMBL None None None None 10.1021/jm00073a022
86274964 159800 0 None -758 2 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cccc(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4110770 159800 0 None -758 2 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cccc(Cl)c2)[C@@H]3C)n1 nan
44281485 114759 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 616 12 1 5 8.3 CO/N=C(\COCc1ccc(-c2ccccc2)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33479 114759 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 616 12 1 5 8.3 CO/N=C(\COCc1ccc(-c2ccccc2)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314873 203082 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL74918 203082 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
73351579 88975 0 None 2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
CHEMBL2370507 88975 0 None 2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
44314945 203287 0 None -9 2 Human 6.4 pKi = 6.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL76727 203287 0 None -9 2 Human 6.4 pKi = 6.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
44363982 35438 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144010 35438 0 None -2 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44364030 36417 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144887 36417 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44434164 166499 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 13 3 5 4.9 CCN(CC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL428905 166499 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 13 3 5 4.9 CCN(CC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44380473 120271 0 None -549 2 Human 6.4 pKi = 6.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355429 120271 0 None -549 2 Human 6.4 pKi = 6.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44314476 104603 0 None -12 2 Human 6.4 pKi = 6.4 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL311387 104603 0 None -12 2 Human 6.4 pKi = 6.4 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44434166 88324 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 534 12 4 5 4.3 NCCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236248 88324 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 534 12 4 5 4.3 NCCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
90663623 106228 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 628 15 4 7 3.4 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL3143849 106228 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 628 15 4 7 3.4 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL117039 206819 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL None None None O=C1C[C@@H](C(=O)O)NC(=O)[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
2132 3687 48 None -97 6 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
5311424 3687 48 None -97 6 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
CHEMBL10188 3687 48 None -97 6 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
10875000 163320 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 518 5 6 5 -0.2 NC(=O)[C@@H]1CNC(=O)CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1 10.1021/jm011127h
CHEMBL420685 163320 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 518 5 6 5 -0.2 NC(=O)[C@@H]1CNC(=O)CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1 10.1021/jm011127h
44315210 102445 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306124 102445 0 None -1 3 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44281723 99166 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 596 11 1 5 8.0 CO/N=C(\COCc1ccc(C(C)(C)C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284145 99166 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 596 11 1 5 8.0 CO/N=C(\COCc1ccc(C(C)(C)C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281666 108718 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32163 108718 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281958 109199 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32273 109199 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281787 162648 0 None 14 2 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL418224 162648 0 None 14 2 Human 8.4 pKi = 8.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363908 35555 0 None 4 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144116 35555 0 None 4 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44315589 203130 0 None -2 3 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75478 203130 0 None -2 3 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44315589 203130 0 None -2 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
CHEMBL75478 203130 0 None -2 3 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
23625634 92149 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 567 12 4 6 3.4 CSc1ccc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc1 10.1021/jm070289w
CHEMBL243503 92149 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 567 12 4 6 3.4 CSc1ccc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc1 10.1021/jm070289w
44380414 57847 0 None -3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167994 57847 0 None -3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9956370 173150 0 None 53 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 470 6 1 4 5.5 CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)NC2CCCCC2)CC1 10.1021/jm000501v
CHEMBL45362 173150 0 None 53 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 470 6 1 4 5.5 CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)NC2CCCCC2)CC1 10.1021/jm000501v
44380279 57514 0 None -3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166975 57514 0 None -3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
49863732 15158 0 None -24 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 15158 0 None -24 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
53325456 58178 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 630 14 3 5 5.1 CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2011.01.074
CHEMBL1683149 58178 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 630 14 3 5 5.1 CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2011.01.074
11800732 180014 0 None -3 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 546 8 1 4 7.2 CC[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL47544 180014 0 None -3 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 546 8 1 4 7.2 CC[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
23626411 91799 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 673 12 3 7 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242624 91799 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 673 12 3 7 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
10392319 194525 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 532 12 1 3 7.3 CCCC(O)(CCC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56143 194525 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 532 12 1 3 7.3 CCCC(O)(CCC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44315591 203266 0 None -1 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76529 203266 0 None -1 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44380337 57134 0 None -6 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL165465 57134 0 None -6 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
23626254 92789 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 594 16 6 7 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CCO)CCO)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL244766 92789 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 594 16 6 7 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CCO)CCO)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
10280686 142545 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 546 11 3 6 3.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2o1 10.1021/jm070289w
CHEMBL389525 142545 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 546 11 3 6 3.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2o1 10.1021/jm070289w
44315573 103319 0 None -1 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL308983 103319 0 None -1 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10145229 9083 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 9083 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281726 109040 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 540 11 1 5 6.7 CO/N=C(\COCc1ccccc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32215 109040 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 540 11 1 5 6.7 CO/N=C(\COCc1ccccc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
22405761 196612 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 0 4 5.9 CC(=O)OCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL57589 196612 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 0 4 5.9 CC(=O)OCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
2110 2922 33 None -138 6 Human 7.4 pKi = 7.4 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
219077 2922 33 None -138 6 Human 7.4 pKi = 7.4 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
3480 2922 33 None -138 6 Human 7.4 pKi = 7.4 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
CHEMBL346178 2922 33 None -138 6 Human 7.4 pKi = 7.4 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
DB04872 2922 33 None -138 6 Human 7.4 pKi = 7.4 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
44312828 103881 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 640 12 0 8 6.1 CC1=C(C(=O)Oc2ccccc2)[S+]([O-])C2C(O1)OC(COCc1ccccc1)C(OCc1ccccc1)C2OCc1ccccc1 10.1016/s0960-894x(02)00471-7
CHEMBL310084 103881 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 640 12 0 8 6.1 CC1=C(C(=O)Oc2ccccc2)[S+]([O-])C2C(O1)OC(COCc1ccccc1)C(OCc1ccccc1)C2OCc1ccccc1 10.1016/s0960-894x(02)00471-7
44312485 202933 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 486 9 1 8 3.8 CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2S1 10.1016/s0960-894x(02)00471-7
CHEMBL73540 202933 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 486 9 1 8 3.8 CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2S1 10.1016/s0960-894x(02)00471-7
44312718 203077 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 9 1 8 2.8 CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
CHEMBL74882 203077 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 9 1 8 2.8 CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
44314577 159333 0 None -16 2 Human 6.4 pKi = 6.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL41068 159333 0 None -16 2 Human 6.4 pKi = 6.4 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
2750 202363 69 None -2 12 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
CHEMBL7002 202363 69 None -2 12 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
44380596 59040 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170727 59040 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44281505 116390 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33833 116390 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
2090 2726 20 None -38 4 Human 7.4 pKi = 7.4 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
5311312 2726 20 None -38 4 Human 7.4 pKi = 7.4 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL437797 2726 20 None -38 4 Human 7.4 pKi = 7.4 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
9940831 14477 0 None -912 4 Human 5.4 pKi = 5.4 Binding
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 14477 0 None -912 4 Human 5.4 pKi = 5.4 Binding
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 14477 0 None -912 4 Human 5.4 pKi = 5.4 Binding
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
44281334 118889 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL34460 118889 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44329530 111912 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 428 4 2 7 4.2 CC(C)c1nc2[nH]c(N3CCC4(CC3)OCCO4)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL329749 111912 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 428 4 2 7 4.2 CC(C)c1nc2[nH]c(N3CCC4(CC3)OCCO4)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL103634 206716 0 None - 1 Human 7.4 pKi = 7.4 Binding
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
52918299 58183 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 640 13 2 6 5.4 COc1c(C(=O)NC2(C(=O)N[C@H](CCCN3CCN(CC4CCOCC4)CC3)Cc3ccccc3)CCCC2)ccc2ccccc12 10.1016/j.bmcl.2011.01.074
CHEMBL1683154 58183 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 640 13 2 6 5.4 COc1c(C(=O)NC2(C(=O)N[C@H](CCCN3CCN(CC4CCOCC4)CC3)Cc3ccccc3)CCCC2)ccc2ccccc12 10.1016/j.bmcl.2011.01.074
44380093 120224 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354892 120224 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
11734825 13116 0 None -549 2 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL119126 13116 0 None -549 2 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
44363978 40249 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL148282 40249 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
22405743 100230 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 462 9 1 3 5.3 CN(CC(CCN1CCC(CCO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
CHEMBL292415 100230 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 462 9 1 3 5.3 CN(CC(CCN1CCC(CCO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
44314732 203385 0 None -3 2 Human 6.3 pKi = 6.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77592 203385 0 None -3 2 Human 6.3 pKi = 6.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44380413 96148 0 None -21 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL263214 96148 0 None -21 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314487 102440 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306097 102440 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
6518171 167733 49 None -4 8 Human 5.3 pKi = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
CHEMBL434063 167733 49 None -4 8 Human 5.3 pKi = 5.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
86274731 160126 0 None -1584 2 Human 4.3 pKi = 4.3 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 412 2 0 7 2.9 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2F)[C@@H]3C)n1 nan
CHEMBL4113428 160126 0 None -1584 2 Human 4.3 pKi = 4.3 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 412 2 0 7 2.9 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2F)[C@@H]3C)n1 nan
3561 18886 34 None -1 11 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
CHEMBL1289 18886 34 None -1 11 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
71461646 78499 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL2112941 78499 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL2390989 208666 13 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity to human NK2 receptor by radioligand displacement assayBinding affinity to human NK2 receptor by radioligand displacement assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.ejmech.2013.01.044
10390024 17772 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 471 5 1 5 3.8 Cc1ccc(S(=O)(=O)N2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
CHEMBL126043 17772 0 None - 1 Rat 8.3 pKi = 8.3 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 471 5 1 5 3.8 Cc1ccc(S(=O)(=O)N2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
44577886 171359 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 14 3 6 4.5 CCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL447011 171359 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 14 3 6 4.5 CCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
44577895 188286 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 14 3 5 5.1 CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL507077 188286 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 14 3 5 5.1 CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44374543 52615 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 773 9 5 6 3.7 O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL159585 52615 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 773 9 5 6 3.7 O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
11251301 142434 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 663 7 6 6 2.0 NC1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL389432 142434 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 663 7 6 6 2.0 NC1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
44343033 9717 0 None - 1 Human 8.3 pKi = 8.3 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 685 9 4 5 5.4 O=C(N[C@H]1CCCCN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)OCc1ccccc1 10.1021/jm011127h
CHEMBL113765 9717 0 None - 1 Human 8.3 pKi = 8.3 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 685 9 4 5 5.4 O=C(N[C@H]1CCCCN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)OCc1ccccc1 10.1021/jm011127h
44315422 102664 0 None -2 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307877 102664 0 None -2 3 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9940831 14477 0 None -1 4 Rabbit 8.3 pKi = 8.3 Binding
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 14477 0 None -1 4 Rabbit 8.3 pKi = 8.3 Binding
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 14477 0 None -1 4 Rabbit 8.3 pKi = 8.3 Binding
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
44380248 57855 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168144 57855 0 None -1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10303126 152650 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 560 11 3 6 3.3 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC=CC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL397702 152650 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 560 11 3 6 3.3 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC=CC1)c1cc2ccccc2s1 10.1021/jm070289w
44305818 14626 0 None -1 4 Rabbit 8.3 pKi = 8.3 Binding
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 14626 0 None -1 4 Rabbit 8.3 pKi = 8.3 Binding
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 14626 0 None -1 4 Rabbit 8.3 pKi = 8.3 Binding
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
10696939 181016 0 None -3 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 506 8 1 4 6.3 CC[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL47713 181016 0 None -3 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 506 8 1 4 6.3 CC[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
118724122 115911 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1296 40 16 22 -3.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)Nc1ccc([N+](=O)[O-])c2nonc12)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm401823z
CHEMBL3360201 115911 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1296 40 16 22 -3.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)Nc1ccc([N+](=O)[O-])c2nonc12)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm401823z
44380081 57801 0 None -100 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167546 57801 0 None -100 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380733 58308 0 None -7 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168437 58308 0 None -7 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44390607 63573 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 558 11 3 5 5.3 CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL180539 63573 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 558 11 3 5 5.3 CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44384147 130171 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 524 9 1 3 6.3 CN(CC(CCN1CCC(CO)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL368372 130171 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 524 9 1 3 6.3 CN(CC(CCN1CCC(CO)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/S0960-894X(00)80694-0
44434188 89176 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 574 11 3 5 5.1 CN1CCCC1CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL237517 89176 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 574 11 3 5 5.1 CN1CCCC1CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434161 89830 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
CHEMBL238392 89830 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
44434170 153894 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 566 15 4 7 2.8 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL398982 153894 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 566 15 4 7 2.8 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCC1 10.1016/j.bmcl.2007.06.053
44390506 63174 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 552 12 3 5 4.1 O=C(Nc1ccc(OCc2cc(F)cc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL179986 63174 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 552 12 3 5 4.1 O=C(Nc1ccc(OCc2cc(F)cc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391084 63996 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181153 63996 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391034 64242 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181581 64242 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390534 64521 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 584 12 3 5 4.9 O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL182082 64521 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 584 12 3 5 4.9 O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391022 121510 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccccc1Oc1ccccc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL359487 121510 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccccc1Oc1ccccc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44331207 167412 0 None - 1 Human 6.3 pKi = 6.3 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 579 12 3 6 3.8 O=C(NCCc1c[nH]c2ccccc12)c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL431838 167412 0 None - 1 Human 6.3 pKi = 6.3 Binding
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 579 12 3 6 3.8 O=C(NCCc1c[nH]c2ccccc12)c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44312406 156801 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 702 13 0 8 7.2 O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1(=O)=O)c1ccccc1 10.1016/s0960-894x(02)00471-7
CHEMBL407769 156801 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 702 13 0 8 7.2 O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1(=O)=O)c1ccccc1 10.1016/s0960-894x(02)00471-7
10717843 100635 0 None -15 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 437 7 1 3 6.1 CC(C)[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL295059 100635 0 None -15 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 437 7 1 3 6.1 CC(C)[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
25222441 195465 0 None -104 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567849 195465 0 None -104 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
44314872 96424 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL265499 96424 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44329351 206378 0 None 13 2 Golden hamster 6.3 pKi = 6.3 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 358 4 2 6 3.1 CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL97958 206378 0 None 13 2 Golden hamster 6.3 pKi = 6.3 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 358 4 2 6 3.1 CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
148124 205370 82 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
CHEMBL3545252 205370 82 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
CHEMBL92 205370 82 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
44363979 120470 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356268 120470 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
138106918 193814 39 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
5311497 193814 39 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
CHEMBL553025 193814 39 None - 1 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
6918276 15435 4 None -56 8 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS nan
CHEMBL1221512 15435 4 None -56 8 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS nan
44281788 99524 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286640 99524 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10044833 106961 0 None 43 2 Golden hamster 7.3 pKi = 7.3 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 372 5 2 6 3.5 CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL318254 106961 0 None 43 2 Golden hamster 7.3 pKi = 7.3 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 372 5 2 6 3.5 CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44329517 206536 0 None -36 2 Human 6.3 pKi = 6.3 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 387 4 1 6 3.1 CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O 10.1016/0960-894X(95)00502-K
CHEMBL98929 206536 0 None -36 2 Human 6.3 pKi = 6.3 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 387 4 1 6 3.1 CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O 10.1016/0960-894X(95)00502-K
44329149 107070 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 392 6 3 5 5.4 CC(C)c1nc2[nH]c(NCc3ccccc3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL318880 107070 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 392 6 3 5 5.4 CC(C)c1nc2[nH]c(NCc3ccccc3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
11057 175575 19 None -1 20 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
3468 175575 19 None -1 20 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL459265 175575 19 None -1 20 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL64894 175575 19 None -1 20 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
44314454 105138 0 None -4 2 Human 6.3 pKi = 6.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312295 105138 0 None -4 2 Human 6.3 pKi = 6.3 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
3823 49951 38 None -36 11 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
76973198 49951 38 None -36 11 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
CHEMBL157101 49951 38 None -36 11 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
44380094 58436 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168584 58436 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363984 35440 0 None -4 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
CHEMBL144011 35440 0 None -4 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
15730 70774 73 None -2 10 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
CHEMBL195437 70774 73 None -2 10 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
44329367 206507 0 None - 1 Golden hamster 4.2 pKi = 4.2 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 425 5 2 6 4.0 CC(C)NC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
CHEMBL98760 206507 0 None - 1 Golden hamster 4.2 pKi = 4.2 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 425 5 2 6 4.0 CC(C)NC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
44329531 206347 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 384 4 2 6 4.0 CC(C)c1nc2[nH]c(N3CCC(=O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL97764 206347 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 384 4 2 6 4.0 CC(C)c1nc2[nH]c(N3CCC(=O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44364003 118490 0 None -9 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342572 118490 0 None -9 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380080 12136 0 None -323 2 Human 6.2 pKi = 6.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL1184507 12136 0 None -323 2 Human 6.2 pKi = 6.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352842 12136 0 None -323 2 Human 6.2 pKi = 6.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
71549913 118351 0 None -588 3 Human 5.2 pKi = 5.2 Binding
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL3422007 118351 0 None -588 3 Human 5.2 pKi = 5.2 Binding
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
44281633 99525 0 None -3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286646 99525 0 None -3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281778 109208 0 None 4 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32279 109208 0 None 4 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281672 113025 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33215 113025 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10718673 178528 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 457 6 1 4 5.4 C[C@H](NC(=O)c1c(CN2CCOCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL47179 178528 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 457 6 1 4 5.4 C[C@H](NC(=O)c1c(CN2CCOCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
10321179 15390 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 443 5 1 3 4.6 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1F 10.1021/jm00019a006
CHEMBL122019 15390 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 443 5 1 3 4.6 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1F 10.1021/jm00019a006
10091869 112332 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 391 5 1 2 4.8 Fc1ccc2[nH]cc(CCN3CCC4(CC3)CCN(Cc3ccccc3)C4)c2c1 10.1021/jm00019a006
CHEMBL330766 112332 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 391 5 1 2 4.8 Fc1ccc2[nH]cc(CCN3CCC4(CC3)CCN(Cc3ccccc3)C4)c2c1 10.1021/jm00019a006
44434196 148692 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394418 148692 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434180 152502 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL397576 152502 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44374557 119090 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 693 11 6 6 1.9 CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(01)00841-1
CHEMBL346285 119090 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 693 11 6 6 1.9 CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(01)00841-1
44374622 119558 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL350596 119558 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
11411718 168381 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@H](NC2CCOCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
CHEMBL438839 168381 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@H](NC2CCOCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
44342797 167572 0 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 754 8 10 9 -0.7 O=C1C[C@H](NC(=O)[C@]2(O)C[C@@H](O)[C@@H](O)[C@H](O)C2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL432986 167572 0 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 754 8 10 9 -0.7 O=C1C[C@H](NC(=O)[C@]2(O)C[C@@H](O)[C@@H](O)[C@H](O)C2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
44300619 197381 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 503 10 0 4 6.4 CC/C(=N\OC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL58638 197381 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 503 10 0 4 6.4 CC/C(=N\OC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44302496 97961 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1081 23 8 14 2.5 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(N)c1ccc([N+](=O)[O-])c2nonc12)C(N)=O 10.1021/jm00039a012
CHEMBL275499 97961 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1081 23 8 14 2.5 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(N)c1ccc([N+](=O)[O-])c2nonc12)C(N)=O 10.1021/jm00039a012
44380338 119970 0 None -4 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354196 119970 0 None -4 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44391153 64198 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181446 64198 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390553 168680 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 544 12 3 5 5.2 CC(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL441115 168680 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 544 12 3 5 5.2 CC(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44434183 166858 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 10 3 5 4.7 O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL429631 166858 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 10 3 5 4.7 O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44390532 64114 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 550 12 3 5 4.5 O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181330 64114 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 550 12 3 5 4.5 O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390539 64233 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.6 CCc1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL181526 64233 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.6 CCc1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44391105 65297 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL183414 65297 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
10603037 116264 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.4 O=C1CC(Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm0010217
CHEMBL337628 116264 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.4 O=C1CC(Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm0010217
44343099 110840 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 567 6 5 4 2.7 O=C1CC(CC2C=CC=CC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm011127h
CHEMBL326790 110840 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 567 6 5 4 2.7 O=C1CC(CC2C=CC=CC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm011127h
44391036 64014 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 494 9 3 5 2.1 O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCCC(O)(c2ccccc2)C1 10.1016/j.bmcl.2004.11.045
CHEMBL181225 64014 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 494 9 3 5 2.1 O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCCC(O)(c2ccccc2)C1 10.1016/j.bmcl.2004.11.045
44391009 122112 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL360354 122112 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
2335 11743 21 None -3 12 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
8478 11743 21 None -3 12 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL1182210 11743 21 None -3 12 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL221753 11743 21 None -3 12 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
176 394 63 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157 394 63 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2566 394 63 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
CHEMBL633 394 63 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
DB01118 394 63 None -4 31 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
3191 102385 93 None -12 25 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
CHEMBL305660 102385 93 None -12 25 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
22405753 197117 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 503 10 1 3 5.5 CC(=O)NCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL58331 197117 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 503 10 1 3 5.5 CC(=O)NCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44329163 110961 0 None 2 2 Golden hamster 5.2 pKi = 5.2 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 344 3 2 6 2.8 Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL327531 110961 0 None 2 2 Golden hamster 5.2 pKi = 5.2 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 344 3 2 6 2.8 Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44363925 39823 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 754 13 1 7 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147924 39823 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 754 13 1 7 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44364002 120535 0 None -8 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 627 11 1 5 6.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356796 120535 0 None -8 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 627 11 1 5 6.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10022196 206546 0 None 45 2 Golden hamster 7.2 pKi = 7.2 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 372 4 2 6 3.7 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL98977 206546 0 None 45 2 Golden hamster 7.2 pKi = 7.2 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 372 4 2 6 3.7 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
9809876 19202 1 None -398 3 Human 7.2 pKi = 7.2 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL129321 19202 1 None -398 3 Human 7.2 pKi = 7.2 Binding
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
44329351 206378 0 None -13 2 Human 5.2 pKi = 5.2 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 358 4 2 6 3.1 CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL97958 206378 0 None -13 2 Human 5.2 pKi = 5.2 Binding
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 358 4 2 6 3.1 CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44337270 108115 0 None 4 2 Human 8.2 pKi = 8.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 665 8 3 6 4.5 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320486 108115 0 None 4 2 Human 8.2 pKi = 8.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 665 8 3 6 4.5 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281587 53276 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 660 11 1 6 7.4 CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL160210 53276 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 660 11 1 6 7.4 CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281342 108943 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 598 11 1 5 7.7 CO/N=C(\COCC12CC3CC(CC(C3)C1)C2)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32201 108943 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 598 11 1 5 7.7 CO/N=C(\COCC12CC3CC(CC(C3)C1)C2)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10032406 39714 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 667 11 0 5 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147824 39714 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 667 11 0 5 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10484667 202849 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL72930 202849 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
25129133 188300 0 None -1122 5 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL507340 188300 0 None -1122 5 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
44300632 101504 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 476 8 1 3 5.7 CN(CC(CCN1CCC(C(C)(C)O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
CHEMBL301437 101504 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 476 8 1 3 5.7 CN(CC(CCN1CCC(C(C)(C)O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
10389401 116598 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 457 5 1 3 5.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc2ccccc12 10.1021/jm00019a006
CHEMBL339311 116598 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 457 5 1 3 5.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc2ccccc12 10.1021/jm00019a006
9843958 199109 1 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL60064 199109 1 None - 1 Rat 8.1 pKi = 8.1 Binding
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
10627614 10392 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 615 6 5 4 3.7 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)CN1 10.1021/jm0010217
CHEMBL116564 10392 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 615 6 5 4 3.7 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)CN1 10.1021/jm0010217
44434190 148986 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL394648 148986 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44577890 129575 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 13 3 6 4.5 CC(C)Oc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL367768 129575 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 13 3 6 4.5 CC(C)Oc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44374504 54564 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL161288 54564 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
11787612 84763 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@@H](NC2CCOCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
CHEMBL225393 84763 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@@H](NC2CCOCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
10627614 10392 0 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 615 6 5 4 3.7 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)CN1 10.1021/jm011127h
CHEMBL116564 10392 0 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 615 6 5 4 3.7 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)CN1 10.1021/jm011127h
44343143 109937 0 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 665 10 7 6 1.4 NCCCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
CHEMBL324532 109937 0 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 665 10 7 6 1.4 NCCCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
9887650 16472 0 None -6 5 Human 8.1 pKi = 8.1 Binding
The compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cellsThe compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cells
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL124208 16472 0 None -6 5 Human 8.1 pKi = 8.1 Binding
The compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cellsThe compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cells
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
44434158 89695 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
CHEMBL238181 89695 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
23625636 92389 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 557 11 4 5 3.0 O=C(Nc1ccc(F)c(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
CHEMBL243726 92389 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 557 11 4 5 3.0 O=C(Nc1ccc(F)c(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
73347011 88979 0 None -1 2 Human 4.1 pKi = 4.1 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 730 6 7 8 -0.6 COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370511 88979 0 None -1 2 Human 4.1 pKi = 4.1 Binding
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 730 6 7 8 -0.6 COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44314154 203358 0 None -24 2 Human 6.1 pKi = 6.1 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 585 10 1 5 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77265 203358 0 None -24 2 Human 6.1 pKi = 6.1 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 585 10 1 5 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
1212 1632 45 None -389 65 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
204 1632 45 None -389 65 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
3372 1632 45 None -389 65 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
CHEMBL726 1632 45 None -389 65 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
DB00623 1632 45 None -389 65 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
51003494 58014 0 None -9 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]NKA from human cloned NK2 receptorDisplacement of [125I]NKA from human cloned NK2 receptor
ChEMBL 556 8 0 4 3.5 CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 10.1016/j.bmcl.2010.12.135
CHEMBL1682680 58014 0 None -9 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]NKA from human cloned NK2 receptorDisplacement of [125I]NKA from human cloned NK2 receptor
ChEMBL 556 8 0 4 3.5 CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 10.1016/j.bmcl.2010.12.135
86274487 159542 0 None -691 3 Human 5.1 pKi = 5.1 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4108583 159542 0 None -691 3 Human 5.1 pKi = 5.1 Binding
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 nan
10479619 112388 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 465 6 1 5 4.1 COC(=O)c1cccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)c1 10.1021/jm00019a006
CHEMBL331011 112388 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 465 6 1 5 4.1 COC(=O)c1cccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)c1 10.1021/jm00019a006
2110 2922 33 None -138 6 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
219077 2922 33 None -138 6 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
3480 2922 33 None -138 6 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
CHEMBL346178 2922 33 None -138 6 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
DB04872 2922 33 None -138 6 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
44391066 63128 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.1 Cc1ccc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL179796 63128 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.1 Cc1ccc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44390533 123351 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 584 12 3 5 4.9 O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL362682 123351 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 584 12 3 5 4.9 O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44312702 102707 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 686 13 0 7 7.5 O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-])c1ccccc1 10.1016/s0960-894x(02)00471-7
CHEMBL308177 102707 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 686 13 0 7 7.5 O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-])c1ccccc1 10.1016/s0960-894x(02)00471-7
44312785 104935 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 9 1 8 2.8 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
CHEMBL311857 104935 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 9 1 8 2.8 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
44391078 62556 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL178451 62556 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390993 131887 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL369735 131887 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
10578880 9748 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.4 O=C1CC(Cc2ccccc2)C(=O)NCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm0010217
CHEMBL114036 9748 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.4 O=C1CC(Cc2ccccc2)C(=O)NCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm0010217
53472113 118353 0 None -398 5 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 519 4 0 7 6.3 C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 10.1021/jm5017413
CHEMBL3422009 118353 0 None -398 5 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 519 4 0 7 6.3 C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 10.1021/jm5017413
10578880 9748 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.4 O=C1CC(Cc2ccccc2)C(=O)NCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL114036 9748 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.4 O=C1CC(Cc2ccccc2)C(=O)NCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
44282001 99347 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 705 12 1 7 7.0 CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285422 99347 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 705 12 1 7 7.0 CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281571 109900 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 718 10 2 5 8.7 CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32430 109900 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 718 10 2 5 8.7 CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281776 113753 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 568 11 1 5 7.3 CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33302 113753 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 568 11 1 5 7.3 CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337202 7893 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109053 7893 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
53317584 58182 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 640 13 2 6 5.4 COc1cc2ccccc2cc1C(=O)NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1 10.1016/j.bmcl.2011.01.074
CHEMBL1683153 58182 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 640 13 2 6 5.4 COc1cc2ccccc2cc1C(=O)NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1 10.1016/j.bmcl.2011.01.074
118724121 115910 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 911 27 10 15 -0.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)Nc1ccc([N+](=O)[O-])c2nonc12)C(C)C)C(N)=O 10.1021/jm401823z
CHEMBL3360200 115910 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 911 27 10 15 -0.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)Nc1ccc([N+](=O)[O-])c2nonc12)C(C)C)C(N)=O 10.1021/jm401823z
44380249 119838 0 None -3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 12 1 6 7.3 CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353027 119838 0 None -3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 12 1 6 7.3 CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
23626253 168183 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 566 14 6 7 2.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CO)CO)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL437164 168183 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 566 14 6 7 2.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CO)CO)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
44380082 57807 0 None -12 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 683 13 1 6 6.7 CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167606 57807 0 None -12 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 683 13 1 6 6.7 CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
20906619 60344 7 None -31 4 Human 5.1 pKi = 5.1 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 396 4 1 4 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760338 60344 7 None -31 4 Human 5.1 pKi = 5.1 Binding
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 396 4 1 4 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
9957749 180112 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 430 6 1 4 4.6 CC(C)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
CHEMBL47555 180112 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 430 6 1 4 4.6 CC(C)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
44266493 166854 0 None -53 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 426 8 2 4 5.2 CC[C@@H](NC(=O)c1c(OCCO)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL429615 166854 0 None -53 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 426 8 2 4 5.2 CC[C@@H](NC(=O)c1c(OCCO)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44329001 206305 0 None - 1 Golden hamster 6.1 pKi = 6.1 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 398 4 1 7 3.7 COC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
CHEMBL97520 206305 0 None - 1 Golden hamster 6.1 pKi = 6.1 Binding
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 398 4 1 7 3.7 COC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
5764 3441 35 None -58 2 Human 5.1 pKi = 5.1 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
6604858 3441 35 None -58 2 Human 5.1 pKi = 5.1 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
CHEMBL9843 3441 35 None -58 2 Human 5.1 pKi = 5.1 Binding
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
6604014 206112 6 None -28 2 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm960818o
CHEMBL9643 206112 6 None -28 2 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm960818o
2110 2922 33 None -138 6 Human 7.1 pKi = 7.1 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
219077 2922 33 None -138 6 Human 7.1 pKi = 7.1 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
3480 2922 33 None -138 6 Human 7.1 pKi = 7.1 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
CHEMBL346178 2922 33 None -138 6 Human 7.1 pKi = 7.1 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
DB04872 2922 33 None -138 6 Human 7.1 pKi = 7.1 Binding
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
CHEMBL386783 210644 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)Nc1ccc([N+](=O)[O-])c2nonc12)C(N)=O 10.1021/jm00039a012
392622 56019 94 None 2 4 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 nan
CHEMBL163 56019 94 None 2 4 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 nan
11273015 57957 0 None -14 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]NKA from human cloned NK2 receptorDisplacement of [125I]NKA from human cloned NK2 receptor
ChEMBL 563 8 1 3 6.0 CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2010.12.135
CHEMBL1682624 57957 0 None -14 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]NKA from human cloned NK2 receptorDisplacement of [125I]NKA from human cloned NK2 receptor
ChEMBL 563 8 1 3 6.0 CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2010.12.135
28417 39799 48 None -1 12 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
CHEMBL1479 39799 48 None -1 12 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
2600 3720 73 None -6 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
2608 3720 73 None -6 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
5405 3720 73 None -6 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
CHEMBL17157 3720 73 None -6 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
DB00342 3720 73 None -6 13 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
44281567 108733 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1ccc(C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32173 108733 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1ccc(C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10032693 109274 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 703 10 1 5 8.3 CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32309 109274 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 703 10 1 5 8.3 CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
23625635 92388 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 647 11 4 5 3.3 O=C(Nc1ccc(I)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
CHEMBL243725 92388 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 647 11 4 5 3.3 O=C(Nc1ccc(I)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
9828448 100772 0 None 50 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 458 7 1 4 5.2 CC(C)C(C)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
CHEMBL296122 100772 0 None 50 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 458 7 1 4 5.2 CC(C)C(C)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
22405762 162603 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 474 9 0 3 5.9 CCC(=O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL417940 162603 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 474 9 0 3 5.9 CCC(=O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
23625787 148830 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 532 12 3 5 2.7 O=C(/C=C/c1ccccc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
CHEMBL394531 148830 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 532 12 3 5 2.7 O=C(/C=C/c1ccccc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
9939040 4941 5 None -2 4 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 4941 5 None -2 4 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
22405734 198334 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 460 9 0 2 6.8 CCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL59542 198334 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 460 9 0 2 6.8 CCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
2726 906 64 None -125 72 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
621 906 64 None -125 72 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
83 906 64 None -125 72 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
CHEMBL71 906 64 None -125 72 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
DB00477 906 64 None -125 72 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
44363435 36957 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 785 14 0 5 9.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145314 36957 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 785 14 0 5 9.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
23625474 152653 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 551 12 3 7 2.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc([N+](=O)[O-])cc1 10.1021/jm070289w
CHEMBL397704 152653 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 551 12 3 7 2.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc([N+](=O)[O-])cc1 10.1021/jm070289w
53232 188040 92 None 1 2 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 nan
CHEMBL503 188040 92 None 1 2 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 nan
104974 3419 27 None -7 7 Rat 6.0 pKi = 6.0 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
2111 3419 27 None -7 7 Rat 6.0 pKi = 6.0 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
3481 3419 27 None -7 7 Rat 6.0 pKi = 6.0 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL308148 3419 27 None -7 7 Rat 6.0 pKi = 6.0 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
DB06660 3419 27 None -7 7 Rat 6.0 pKi = 6.0 Binding
The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
44314486 105176 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 739 13 0 7 6.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312528 105176 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 739 13 0 7 6.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
23625322 91877 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 534 11 3 6 2.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242848 91877 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 534 11 3 6 2.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC1)c1cc2ccccc2s1 10.1021/jm070289w
44392318 122028 0 None -38018 2 Human 5.0 pKi = 5.0 Binding
Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor
ChEMBL 519 7 0 4 5.0 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL360134 122028 0 None -38018 2 Human 5.0 pKi = 5.0 Binding
Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor
ChEMBL 519 7 0 4 5.0 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
44550460 195361 0 None -69 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 537 8 0 3 5.9 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567198 195361 0 None -69 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 537 8 0 3 5.9 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
44314547 102402 0 None -5 2 Human 6.0 pKi = 6.0 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 661 11 0 5 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL305826 102402 0 None -5 2 Human 6.0 pKi = 6.0 Binding
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 661 11 0 5 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
64143 197186 57 None -1 8 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C nan
CHEMBL584 197186 57 None -1 8 Human 5.0 pKi = 5.0 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C nan
2247 502 77 None -44 41 Human 6.0 pKi = 6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 502 77 None -44 41 Human 6.0 pKi = 6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 502 77 None -44 41 Human 6.0 pKi = 6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 502 77 None -44 41 Human 6.0 pKi = 6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 502 77 None -44 41 Human 6.0 pKi = 6 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
71549635 160327 0 None -1412 3 Human 5.0 pKi = 5 Binding
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 450 4 0 8 4.4 C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 nan
CHEMBL4115030 160327 0 None -1412 3 Human 5.0 pKi = 5 Binding
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 450 4 0 8 4.4 C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 nan
2112 597 0 None - 1 Human 6.0 pKd = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2115 1817 17 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7562907
2115 1817 17 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7682062
2115 1817 17 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7713168
9953599 1817 17 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7562907
9953599 1817 17 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7682062
9953599 1817 17 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7713168
CHEMBL2110370 1817 17 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7562907
CHEMBL2110370 1817 17 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7682062
CHEMBL2110370 1817 17 None -8 3 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 7713168
2089 2725 21 None 102 5 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10455255
3795 2725 21 None 102 5 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10455255
5311311 2725 21 None 102 5 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10455255
CHEMBL217406 2725 21 None 102 5 Human 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10455255
104974 3419 27 None -7 7 Rat 9.7 pKd = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7719707
2111 3419 27 None -7 7 Rat 9.7 pKd = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7719707
3481 3419 27 None -7 7 Rat 9.7 pKd = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7719707
CHEMBL308148 3419 27 None -7 7 Rat 9.7 pKd = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7719707
DB06660 3419 27 None -7 7 Rat 9.7 pKd = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7719707
9850582 195566 21 125I-[MePhe7]-NKB -1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195566 21 125I-[MePhe7]-NKB -1 6 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
9850582 195566 21 3H-NEUROKININ A -1 6 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195566 21 3H-NEUROKININ A -1 6 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
9850582 195566 21 125I-Iodohistidyl -1 6 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195566 21 125I-Iodohistidyl -1 6 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 214302 0 125I-Iodohistidyl -1 6 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 214302 0 125I-Iodohistidyl -1 6 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
9850582 195566 21 125I-Iodohistidyl 1 6 Bovine 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195566 21 125I-Iodohistidyl 1 6 Bovine 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 214302 0 125I-[MePhe7]-NKB -1 6 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 214302 0 125I-Iodohistidyl 1 6 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 214302 0 125I-Iodohistidyl -1 6 Bovine 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 214302 0 125I-Iodohistidyl -1 6 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 214304 0 125I-Iodohistidyl-NKA -95 8 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
202 1480 0 UNDEFINED -9 31 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 1480 0 UNDEFINED -9 31 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 1480 0 UNDEFINED -9 31 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 1480 0 UNDEFINED -9 31 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 1480 0 UNDEFINED -9 31 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
5656 201377 82 UNDEFINED -7 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 201377 82 UNDEFINED -7 40 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
54841 201437 51 UNDEFINED -1 28 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
CHEMBL641 201437 51 UNDEFINED -1 28 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
3075702 215594 0 125I-NKA -2 37 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
119376 1811 41 3H-NEUROKININ A -54954 26 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
247 1811 41 3H-NEUROKININ A -54954 26 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
CHEMBL33884 1811 41 3H-NEUROKININ A -54954 26 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
3294 1975 106 125I-NKA -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 1975 106 125I-NKA -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 1975 106 125I-NKA -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 1975 106 125I-NKA -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 1975 106 125I-NKA -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
243 3153 85 3H-SR 48968 -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 3153 85 3H-SR 48968 -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 3153 85 3H-SR 48968 -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 3153 85 3H-SR 48968 -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 3153 85 3H-SR 48968 -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
21830793 91403 5 3H-8-OH-DPAT -66069 46 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
CHEMBL2413154 91403 5 3H-8-OH-DPAT -66069 46 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
44208932 140176 6 UNDEFINED -120226 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
CHEMBL381689 140176 6 UNDEFINED -120226 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
5079497 214303 0 125I-[MePhe7]-NKB -1445 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 841 26 8 10 -0.0 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)CCC(=O)O None
None 214358 0 125I-Neurokinin A -1 13 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 164 3 1 3 0.8 C1CNC1COC2=CN=CC=C2 None
119380 214359 0 125I-Neurokinin A -1 8 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 166 1 0 3 1.8 CC1=NOC(=C1)C2CCCN2C None
None 214752 0 125I-NKA -10471285 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 372 2 1 3 4.4 CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl None
2098 3638 31 125I-[MePhe7]-NKB -457 6 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3638 31 125I-[MePhe7]-NKB -457 6 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3638 31 125I-[MePhe7]-NKB -457 6 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3638 31 125I-[MePhe7]-NKB -457 6 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3638 31 125I-[MePhe7]-NKB -457 6 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase None None None None None
133090 97971 18 125I-NKA -9 3 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
133090 97971 18 125I-[MePhe7]-NKB -9 3 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
CHEMBL275544 97971 18 125I-NKA -9 3 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
CHEMBL275544 97971 18 125I-[MePhe7]-NKB -9 3 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
None 214433 0 125I-Iodohistidyl -1023 5 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
None 214301 0 125I-[MePhe7]-NKB -20 4 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 1210 38 14 16 -1.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)N None
None 214302 0 125I-Iodohistidyl -3 6 Guinea pig 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 214304 0 3H-NEUROKININ A -54 8 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214304 0 125I-Iodohistidyl-NKA -54 8 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214304 0 125I-Iodohistidyl-NKA -95 8 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214434 0 125I-Iodohistidyl -3 6 Bovine 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
None 214304 0 125I-NEUROPEPTIDE Y -95 8 Guinea pig 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214434 0 125I-Iodohistidyl -12 6 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
None 214304 0 125I-[MePhe7]-NKB -54 8 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214304 0 125I-NKA -54 8 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214434 0 125I-Iodohistidyl -12 6 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
64143 197186 57 None -1 8 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C None
CHEMBL584 197186 57 None -1 8 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C None
53232 188040 92 None 1 2 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 None
CHEMBL503 188040 92 None 1 2 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 None
2726 906 64 None -125 72 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 906 64 None -125 72 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 906 64 None -125 72 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 906 64 None -125 72 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 906 64 None -125 72 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
28417 39799 48 None -1 12 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C None
CHEMBL1479 39799 48 None -1 12 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C None
1212 1632 45 None -389 65 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 1632 45 None -389 65 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 1632 45 None -389 65 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 1632 45 None -389 65 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 1632 45 None -389 65 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
176 394 63 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
2157 394 63 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
2566 394 63 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
CHEMBL633 394 63 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
DB01118 394 63 None -4 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
3823 49951 38 None -36 11 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
76973198 49951 38 None -36 11 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
CHEMBL157101 49951 38 None -36 11 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
2812 4711 96 None -28 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
CHEMBL104 4711 96 None -28 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
448537 159703 86 None -26 25 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 None
CHEMBL411 159703 86 None -26 25 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 None
657255 197406 29 None -17 15 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 None
CHEMBL588119 197406 29 None -17 15 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1 None
441243 9743 53 None -19 8 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 None
CHEMBL114 9743 53 None -19 8 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 None
138106885 166358 71 None -1 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C None
36314 166358 71 None -1 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C None
CHEMBL428647 166358 71 None -1 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C None
3198 203802 73 None -21 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1201049 203802 73 None -21 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL808 203802 73 None -21 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
5362440 9926 58 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O None
CHEMBL115 9926 58 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O None
5318 15400 44 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1200348 15400 44 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1221 15400 44 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
4189 205195 91 None -18 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1559 205195 91 None -18 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL91 205195 91 None -18 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
2406 99938 84 None -16 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O None
CHEMBL290106 99938 84 None -16 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O None
1548955 88153 17 None -1 18 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 405 9 0 2 6.6 CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 None
2800 88153 17 None -1 18 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 405 9 0 2 6.6 CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 None
CHEMBL2355051 88153 17 None -1 18 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 405 9 0 2 6.6 CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 None
1024 1263 69 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central None None None None None
162639143 1263 69 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central None None None None None
5284373 1263 69 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central None None None None None
760 1263 69 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central None None None None None
CHEMBL160 1263 69 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central None None None None None
DB00091 1263 69 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central None None None None None
3598 187238 73 None -1 7 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl None
CHEMBL496 187238 73 None -1 7 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl None
133 2460 48 None -165 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 2460 48 None -165 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 2460 48 None -165 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 2460 48 None -165 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 2460 48 None -165 42 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
2351 3234 60 None -13 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
2820 3234 60 None -13 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
5035 3234 60 None -13 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
CHEMBL81 3234 60 None -13 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
DB00481 3234 60 None -13 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
1836 2554 56 None -40 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 None
3340 2554 56 None -40 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 None
5281040 2554 56 None -40 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 None
CHEMBL787 2554 56 None -40 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 None
DB00471 2554 56 None -40 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 None
1016 3690 75 None -16 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2561 3690 75 None -16 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2733526 3690 75 None -16 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
5384 3690 75 None -16 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
CHEMBL83 3690 75 None -16 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
DB00675 3690 75 None -16 35 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
5353853 17803 41 None -14 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
9556529 17803 41 None -14 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1262 17803 41 None -14 15 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
2247 502 77 None -44 41 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
249 502 77 None -44 41 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
2603 502 77 None -44 41 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
CHEMBL296419 502 77 None -44 41 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
DB00637 502 77 None -44 41 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
2600 3720 73 None -6 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O None
2608 3720 73 None -6 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O None
5405 3720 73 None -6 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O None
CHEMBL17157 3720 73 None -6 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O None
DB00342 3720 73 None -6 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O None
392622 56019 94 None 2 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 None
CHEMBL163 56019 94 None 2 4 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 None
2335 11743 21 None -3 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 None
8478 11743 21 None -3 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 None
CHEMBL1182210 11743 21 None -3 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 None
CHEMBL221753 11743 21 None -3 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 None
3191 102385 93 None -12 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 None
CHEMBL305660 102385 93 None -12 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 None
11057 175575 19 None -1 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
3468 175575 19 None -1 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
CHEMBL459265 175575 19 None -1 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
CHEMBL64894 175575 19 None -1 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
138106918 193814 39 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 None
5311497 193814 39 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 None
CHEMBL553025 193814 39 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 None
148124 205370 82 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C None
CHEMBL3545252 205370 82 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C None
CHEMBL92 205370 82 None - 1 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C None
3561 18886 34 None -1 11 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl None
CHEMBL1289 18886 34 None -1 11 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
Drug Central 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl None
9850582 195566 21 125I-Iodohistidyl -1 6 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195566 21 125I-Iodohistidyl -1 6 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 214304 0 125I-NEUROPEPTIDE Y -95 8 Guinea pig 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
1973 201790 12 125I-NKA -3 35 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 201790 12 125I-NKA -3 35 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 201790 12 125I-NKA -3 35 Rat 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
5771 4085 0 None -17 2 Human 3.8 pKi = 3.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 471 5 2 8 2.7 O/N=C(/C(=O)N1CCN(CC1)c1nc(Nc2ccc(cc2)Cl)c2c(n1)C(=O)N(C2)C(C)C)\C 7562491
9847605 4085 0 None -17 2 Human 3.8 pKi = 3.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 471 5 2 8 2.7 O/N=C(/C(=O)N1CCN(CC1)c1nc(Nc2ccc(cc2)Cl)c2c(n1)C(=O)N(C2)C(C)C)\C 7562491
5771 4085 0 None 17 2 Guinea pig 5.1 pKi = 5.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 471 5 2 8 2.7 O/N=C(/C(=O)N1CCN(CC1)c1nc(Nc2ccc(cc2)Cl)c2c(n1)C(=O)N(C2)C(C)C)\C 7562491
9847605 4085 0 None 17 2 Guinea pig 5.1 pKi = 5.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 471 5 2 8 2.7 O/N=C(/C(=O)N1CCN(CC1)c1nc(Nc2ccc(cc2)Cl)c2c(n1)C(=O)N(C2)C(C)C)\C 7562491
107967 1616 0 None -1000 2 Human 6.1 pKi = 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 11937780
2114 1616 0 None -1000 2 Human 6.1 pKi = 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 11937780
CHEMBL1416993 1616 0 None -1000 2 Human 6.1 pKi = 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 11937780
2087 1889 0 None -28183 4 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
164286 3220 0 None - 1 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2118 3220 0 None - 1 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
10327625 4061 0 None - 1 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 607 9 0 2 8.3 CC(Oc1cccc(c1)CC(=O)N1CCCC(C1)(CC[N+]1(C)CCC(CC1)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 11937780
2122 4061 0 None - 1 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 607 9 0 2 8.3 CC(Oc1cccc(c1)CC(=O)N1CCCC(C1)(CC[N+]1(C)CCC(CC1)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 11937780
2132 3687 48 None -97 6 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 9190866
5311424 3687 48 None -97 6 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 9190866
CHEMBL10188 3687 48 None -97 6 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 9190866
2110 2922 33 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
2110 2922 33 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9190866
219077 2922 33 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
219077 2922 33 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9190866
3480 2922 33 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
3480 2922 33 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9190866
CHEMBL346178 2922 33 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
CHEMBL346178 2922 33 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9190866
DB04872 2922 33 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
DB04872 2922 33 None -138 6 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9190866
124003 2451 17 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2116 2451 17 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
CHEMBL507824 2451 17 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2089 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11137709
2089 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2089 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2089 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
3795 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11137709
3795 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3795 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
3795 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
5311311 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11137709
5311311 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
5311311 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
5311311 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL217406 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11137709
CHEMBL217406 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL217406 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
CHEMBL217406 2725 21 None 102 5 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2123 2723 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16979621
2123 2723 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9484857
3086682 2723 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16979621
3086682 2723 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9484857
2120 4058 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 639 10 1 6 5.9 COc1cc(cc(c1OC)OC)C(=O)N(CC(c1ccc(c(c1)Cl)Cl)CCN1CCC2(CC1)NC(=O)Cc1c2cccc1)C 11937780
9852373 4058 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 639 10 1 6 5.9 COc1cc(cc(c1OC)OC)C(=O)N(CC(c1ccc(c(c1)Cl)Cl)CCN1CCC2(CC1)NC(=O)Cc1c2cccc1)C 11937780
5778 4086 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 516 8 1 3 5.1 O=C1NCCCN1C1CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C 22149761
9871234 4086 0 None - 1 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 516 8 1 3 5.1 O=C1NCCCN1C1CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C 22149761
5769 3468 3 None 194 2 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 11356103
9806459 3468 3 None 194 2 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 11356103
CHEMBL295770 3468 3 None 194 2 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 11356103
3901 2452 0 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11063600
5311274 2452 0 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11063600
104974 3419 27 None -7 7 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1313515
2111 3419 27 None -7 7 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1313515
3481 3419 27 None -7 7 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1313515
CHEMBL308148 3419 27 None -7 7 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1313515
DB06660 3419 27 None -7 7 Rat 9.3 pKi = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1313515
104974 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
104974 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7682062
104974 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
2111 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
2111 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7682062
2111 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
3481 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
3481 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7682062
3481 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
CHEMBL308148 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
CHEMBL308148 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7682062
CHEMBL308148 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
DB06660 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
DB06660 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 7682062
DB06660 3419 27 None 1 7 Human 9.6 pKi = 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
3882 1827 0 None - 1 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8027981
6324620 1827 0 None - 1 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8027981
10483085 4059 0 None - 1 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 567 7 1 3 6.0 O=C1Cc2ccccc2C2(N1)CCN(CC2)CCC(c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccc(cc1)F)C 11937780
2121 4059 0 None - 1 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 567 7 1 3 6.0 O=C1Cc2ccccc2C2(N1)CCN(CC2)CCC(c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccc(cc1)F)C 11937780
11527495 1937 15 None - 1 Human 10.1 pKi None 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 16979621
2117 1937 15 None - 1 Human 10.1 pKi None 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 16979621
CHEMBL266125 1937 15 None - 1 Human 10.1 pKi None 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 16979621
DB12042 1937 15 None - 1 Human 10.1 pKi None 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 16979621
2090 2726 20 None -38 4 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2090 2726 20 None -38 4 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
5311312 2726 20 None -38 4 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
5311312 2726 20 None -38 4 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL437797 2726 20 None -38 4 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
CHEMBL437797 2726 20 None -38 4 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2098 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2098 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
2098 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
36511 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
36511 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
36511 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
3805 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3805 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
3805 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
3835 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3835 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
3835 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL235363 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL235363 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7682062
CHEMBL235363 3638 31 None -457 6 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2113 3045 0 None -199 3 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2106 3490 3 None -1 3 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
9875034 3490 3 None -1 3 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
CHEMBL77023 3490 3 None -1 3 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858