Ligand source activities (1 row/activity)
Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
CHEMBL1627325 | 207068 | 0 | None | -1 | 8 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)(C)C)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O | 10.1021/jm900604g | ||||
2098 | 3638 | 31 | None | -1 | 11 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm900604g | ||||
36511 | 3638 | 31 | None | -1 | 11 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm900604g | ||||
3805 | 3638 | 31 | None | -1 | 11 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm900604g | ||||
3835 | 3638 | 31 | None | -1 | 11 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm900604g | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 11 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm900604g | ||||
CHEMBL384518 | 210581 | 9 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm000093v | ||||
2098 | 3638 | 31 | None | -1 | 11 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm2017072 | ||||
36511 | 3638 | 31 | None | -1 | 11 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm2017072 | ||||
3805 | 3638 | 31 | None | -1 | 11 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm2017072 | ||||
3835 | 3638 | 31 | None | -1 | 11 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm2017072 | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 11 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm2017072 | ||||
2098 | 3638 | 31 | None | -1 | 11 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm000093v | ||||
36511 | 3638 | 31 | None | -1 | 11 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm000093v | ||||
3805 | 3638 | 31 | None | -1 | 11 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm000093v | ||||
3835 | 3638 | 31 | None | -1 | 11 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm000093v | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 11 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm000093v | ||||
2098 | 3638 | 31 | None | -2 | 11 | Guinea pig | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00169a003 | ||||
36511 | 3638 | 31 | None | -2 | 11 | Guinea pig | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00169a003 | ||||
3805 | 3638 | 31 | None | -2 | 11 | Guinea pig | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00169a003 | ||||
3835 | 3638 | 31 | None | -2 | 11 | Guinea pig | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00169a003 | ||||
CHEMBL235363 | 3638 | 31 | None | -2 | 11 | Guinea pig | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00169a003 | ||||
73356363 | 89074 | 0 | None | 9 | 2 | Guinea pig | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 711 | 22 | 7 | 8 | 0.9 | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O | 10.1021/jm00169a003 | ||
CHEMBL2372949 | 89074 | 0 | None | 9 | 2 | Guinea pig | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 711 | 22 | 7 | 8 | 0.9 | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O | 10.1021/jm00169a003 | ||
44355648 | 96676 | 0 | None | -22 | 3 | Guinea pig | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 994 | 29 | 10 | 13 | -1.5 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL267712 | 96676 | 0 | None | -22 | 3 | Guinea pig | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 994 | 29 | 10 | 13 | -1.5 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O | 10.1021/jm00100a027 | ||
44355117 | 21588 | 0 | None | -19 | 3 | Guinea pig | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 946 | 28 | 10 | 13 | -2.1 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL131923 | 21588 | 0 | None | -19 | 3 | Guinea pig | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 946 | 28 | 10 | 13 | -2.1 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O | 10.1021/jm00100a027 | ||
44297675 | 100153 | 0 | None | -47 | 2 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 711 | 22 | 7 | 8 | 0.9 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O | 10.1021/jm00169a003 | ||
CHEMBL291903 | 100153 | 0 | None | -47 | 2 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 711 | 22 | 7 | 8 | 0.9 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O | 10.1021/jm00169a003 | ||
10259515 | 156595 | 0 | None | 954 | 2 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 751 | 22 | 6 | 8 | 1.8 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL407511 | 156595 | 0 | None | 954 | 2 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 751 | 22 | 6 | 8 | 1.8 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL263185 | 208816 | 4 | None | 2 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O | 10.1021/jm000093v | ||||
2089 | 2725 | 21 | None | -6 | 8 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00100a027 | ||||
3795 | 2725 | 21 | None | -6 | 8 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00100a027 | ||||
5311311 | 2725 | 21 | None | -6 | 8 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00100a027 | ||||
CHEMBL217406 | 2725 | 21 | None | -6 | 8 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00100a027 | ||||
CHEMBL415159 | 211427 | 4 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O | 10.1021/jm000093v | ||||
44297866 | 101574 | 0 | None | -38 | 2 | Guinea pig | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 723 | 21 | 6 | 8 | 1.0 | CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O | 10.1021/jm00169a003 | ||
CHEMBL301841 | 101574 | 0 | None | -38 | 2 | Guinea pig | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 723 | 21 | 6 | 8 | 1.0 | CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O | 10.1021/jm00169a003 | ||
CHEMBL441061 | 212131 | 16 | None | 2 | 2 | Guinea pig | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O | 10.1021/jm00112a018 | ||||
73348740 | 89076 | 0 | None | 51 | 2 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 737 | 21 | 6 | 8 | 1.4 | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O | 10.1021/jm00169a003 | ||
CHEMBL2372953 | 89076 | 0 | None | 51 | 2 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 737 | 21 | 6 | 8 | 1.4 | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O | 10.1021/jm00169a003 | ||
44355678 | 23286 | 0 | None | 4 | 2 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 777 | 21 | 5 | 8 | 2.3 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL133362 | 23286 | 0 | None | 4 | 2 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 777 | 21 | 5 | 8 | 2.3 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O | 10.1021/jm00100a027 | ||
10350201 | 116659 | 0 | None | -6 | 2 | Guinea pig | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 763 | 21 | 5 | 8 | 1.8 | CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL339391 | 116659 | 0 | None | -6 | 2 | Guinea pig | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 763 | 21 | 5 | 8 | 1.8 | CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O | 10.1021/jm00100a027 | ||
10327810 | 116236 | 0 | None | -31 | 2 | Guinea pig | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | 763 | 21 | 5 | 8 | 1.8 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL337465 | 116236 | 0 | None | -31 | 2 | Guinea pig | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | 763 | 21 | 5 | 8 | 1.8 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O | 10.1021/jm00100a027 | ||
10055612 | 95978 | 0 | None | 31 | 3 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 711 | 23 | 7 | 8 | 0.9 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL262049 | 95978 | 0 | None | 31 | 3 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 711 | 23 | 7 | 8 | 0.9 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O | 10.1021/jm00100a027 | ||
14860666 | 104940 | 0 | None | -3 | 2 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 710 | 21 | 6 | 8 | 1.0 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)COC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O | 10.1021/jm00112a018 | ||
CHEMBL311917 | 104940 | 0 | None | -3 | 2 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 710 | 21 | 6 | 8 | 1.0 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)COC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O | 10.1021/jm00112a018 | ||
2098 | 3638 | 31 | None | -2 | 11 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00169a003 | ||||
36511 | 3638 | 31 | None | -2 | 11 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00169a003 | ||||
3805 | 3638 | 31 | None | -2 | 11 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00169a003 | ||||
3835 | 3638 | 31 | None | -2 | 11 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00169a003 | ||||
CHEMBL235363 | 3638 | 31 | None | -2 | 11 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00169a003 | ||||
15931130 | 101511 | 0 | None | -1000 | 2 | Guinea pig | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 737 | 21 | 6 | 8 | 1.4 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O | 10.1021/jm00169a003 | ||
CHEMBL301477 | 101511 | 0 | None | -1000 | 2 | Guinea pig | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 737 | 21 | 6 | 8 | 1.4 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O | 10.1021/jm00169a003 | ||
5311135 | 21523 | 10 | None | -1148 | 3 | Guinea pig | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 920 | 29 | 11 | 13 | -2.4 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL131872 | 21523 | 10 | None | -1148 | 3 | Guinea pig | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 920 | 29 | 11 | 13 | -2.4 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O | 10.1021/jm00100a027 | ||
44355179 | 24144 | 0 | None | -33 | 2 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 962 | 30 | 11 | 13 | -2.2 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL134091 | 24144 | 0 | None | -33 | 2 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 962 | 30 | 11 | 13 | -2.2 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL134481 | 206987 | 0 | None | -1 | 3 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm00100a027 | ||||
2098 | 3638 | 31 | None | -2 | 11 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00100a027 | ||||
36511 | 3638 | 31 | None | -2 | 11 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00100a027 | ||||
3805 | 3638 | 31 | None | -2 | 11 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00100a027 | ||||
3835 | 3638 | 31 | None | -2 | 11 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00100a027 | ||||
CHEMBL235363 | 3638 | 31 | None | -2 | 11 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00100a027 | ||||
10395375 | 116157 | 0 | None | -2 | 2 | Guinea pig | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 763 | 21 | 5 | 8 | 1.8 | CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL337037 | 116157 | 0 | None | -2 | 2 | Guinea pig | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 763 | 21 | 5 | 8 | 1.8 | CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O | 10.1021/jm00100a027 | ||
10462850 | 24059 | 0 | None | -36 | 2 | Guinea pig | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 763 | 21 | 5 | 8 | 1.8 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL134012 | 24059 | 0 | None | -36 | 2 | Guinea pig | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 763 | 21 | 5 | 8 | 1.8 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O | 10.1021/jm00100a027 | ||
15931129 | 193308 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 697 | 22 | 7 | 8 | 0.6 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O | 10.1021/jm00169a003 | ||
CHEMBL54622 | 193308 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 697 | 22 | 7 | 8 | 0.6 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O | 10.1021/jm00169a003 | ||
CHEMBL81919 | 214109 | 0 | None | -676 | 2 | Guinea pig | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O | 10.1021/jm00112a018 | ||||
CHEMBL335054 | 209734 | 0 | None | -20 | 3 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C(N)=O | 10.1021/jm00100a027 | ||||
44297852 | 98550 | 0 | None | -7 | 2 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 763 | 20 | 5 | 8 | 1.9 | CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O | 10.1021/jm00169a003 | ||
CHEMBL280020 | 98550 | 0 | None | -7 | 2 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 763 | 20 | 5 | 8 | 1.9 | CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O | 10.1021/jm00169a003 | ||
2090 | 2726 | 20 | None | -6 | 9 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00100a027 | ||||
5311312 | 2726 | 20 | None | -6 | 9 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00100a027 | ||||
CHEMBL437797 | 2726 | 20 | None | -6 | 9 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00100a027 | ||||
11765601 | 95977 | 0 | None | -9 | 2 | Guinea pig | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 751 | 22 | 6 | 8 | 1.8 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL262048 | 95977 | 0 | None | -9 | 2 | Guinea pig | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 751 | 22 | 6 | 8 | 1.8 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O | 10.1021/jm00100a027 | ||
44355368 | 25437 | 0 | None | -1 | 3 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 737 | 22 | 6 | 8 | 1.4 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL135186 | 25437 | 0 | None | -1 | 3 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 737 | 22 | 6 | 8 | 1.4 | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O | 10.1021/jm00100a027 | ||
10009596 | 115010 | 0 | None | 1 | 2 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 663 | 22 | 7 | 8 | 0.4 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O | 10.1021/jm00100a027 | ||
CHEMBL335248 | 115010 | 0 | None | 1 | 2 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 663 | 22 | 7 | 8 | 0.4 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O | 10.1021/jm00100a027 | ||
73356365 | 89077 | 0 | None | - | 1 | Guinea pig | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 752 | 21 | 8 | 7 | 1.5 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm00169a003 | ||
CHEMBL2372954 | 89077 | 0 | None | - | 1 | Guinea pig | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 752 | 21 | 8 | 7 | 1.5 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm00169a003 | ||
108167 | 2813 | 5 | None | 58 | 2 | Guinea pig | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 619 | 9 | 0 | 2 | 8.2 | CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C | 10.1016/s0960-894x(98)00260-1 | ||
2107 | 2813 | 5 | None | 58 | 2 | Guinea pig | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 619 | 9 | 0 | 2 | 8.2 | CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL1178725 | 2813 | 5 | None | 58 | 2 | Guinea pig | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 619 | 9 | 0 | 2 | 8.2 | CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C | 10.1016/s0960-894x(98)00260-1 | ||
135434109 | 4217 | 0 | None | - | 1 | Rat | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 446 | 6 | 2 | 5 | 5.3 | C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL100636 | 4217 | 0 | None | - | 1 | Rat | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 446 | 6 | 2 | 5 | 5.3 | C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 | 10.1016/S0960-894X(97)10118-4 | ||
9967131 | 205772 | 1 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 326 | 6 | 2 | 4 | 3.3 | COc1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL94461 | 205772 | 1 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 326 | 6 | 2 | 4 | 3.3 | COc1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 | 10.1016/s0960-894x(98)00012-2 | ||
10363809 | 111638 | 17 | None | - | 1 | Human | 10.0 | pIC50 | = | 10.0 | Functional | ChEMBL | 403 | 7 | 2 | 5 | 2.7 | COc1ccc(N(C)S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL329007 | 111638 | 17 | None | - | 1 | Human | 10.0 | pIC50 | = | 10.0 | Functional | ChEMBL | 403 | 7 | 2 | 5 | 2.7 | COc1ccc(N(C)S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
44328454 | 168173 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 330 | 5 | 2 | 3 | 3.9 | COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL437075 | 168173 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 330 | 5 | 2 | 3 | 3.9 | COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
10111225 | 205744 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 394 | 7 | 2 | 4 | 4.6 | CCOc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL94328 | 205744 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 394 | 7 | 2 | 4 | 4.6 | CCOc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
10477054 | 4426 | 0 | None | - | 1 | Rat | 9.8 | pIC50 | = | 9.8 | Functional | ChEMBL | 417 | 4 | 1 | 2 | 6.3 | C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL102032 | 4426 | 0 | None | - | 1 | Rat | 9.8 | pIC50 | = | 9.8 | Functional | ChEMBL | 417 | 4 | 1 | 2 | 6.3 | C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
10458573 | 4299 | 0 | None | - | 1 | Rat | 9.8 | pIC50 | = | 9.8 | Functional | ChEMBL | 498 | 6 | 1 | 4 | 6.3 | C[C@@H](O[C@H]1CCCN(Cc2nc[nH]n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL101148 | 4299 | 0 | None | - | 1 | Rat | 9.8 | pIC50 | = | 9.8 | Functional | ChEMBL | 498 | 6 | 1 | 4 | 6.3 | C[C@@H](O[C@H]1CCCN(Cc2nc[nH]n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
135488049 | 206474 | 0 | None | - | 1 | Rat | 9.8 | pIC50 | = | 9.8 | Functional | ChEMBL | 514 | 6 | 2 | 5 | 6.0 | C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL98524 | 206474 | 0 | None | - | 1 | Rat | 9.8 | pIC50 | = | 9.8 | Functional | ChEMBL | 514 | 6 | 2 | 5 | 6.0 | C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
2102 | 1166 | 17 | None | 6 | 2 | Human | 9.8 | pIC50 | = | 9.8 | Functional | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm1016285 | ||
5311057 | 1166 | 17 | None | 6 | 2 | Human | 9.8 | pIC50 | = | 9.8 | Functional | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm1016285 | ||
CHEMBL441225 | 1166 | 17 | None | 6 | 2 | Human | 9.8 | pIC50 | = | 9.8 | Functional | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm1016285 | ||
10480465 | 206673 | 0 | None | 1 | 2 | Rat | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 484 | 6 | 1 | 4 | 5.8 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL99792 | 206673 | 0 | None | 1 | 2 | Rat | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 484 | 6 | 1 | 4 | 5.8 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
10272852 | 107407 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 408 | 7 | 2 | 4 | 5.0 | CC(C)Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL319301 | 107407 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 408 | 7 | 2 | 4 | 5.0 | CC(C)Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
9821217 | 107244 | 17 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL319118 | 107244 | 17 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL3215877 | 107244 | 17 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
9871754 | 5337 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1016/j.bmc.2008.09.037 | ||
CHEMBL107172 | 5337 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1016/j.bmc.2008.09.037 | ||
2098 | 3638 | 31 | None | -1 | 11 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)10097-X | ||||
36511 | 3638 | 31 | None | -1 | 11 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)10097-X | ||||
3805 | 3638 | 31 | None | -1 | 11 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)10097-X | ||||
3835 | 3638 | 31 | None | -1 | 11 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)10097-X | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 11 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)10097-X | ||||
44433394 | 146125 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 406 | 6 | 2 | 3 | 5.1 | COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2007.09.053 | ||
CHEMBL392368 | 146125 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 406 | 6 | 2 | 3 | 5.1 | COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2007.09.053 | ||
44433394 | 146125 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 406 | 6 | 2 | 3 | 5.1 | COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm1013693 | ||
CHEMBL392368 | 146125 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 406 | 6 | 2 | 3 | 5.1 | COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm1013693 | ||
9960689 | 11900 | 0 | None | - | 1 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 619 | 9 | 0 | 2 | 8.2 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL1183286 | 11900 | 0 | None | - | 1 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 619 | 9 | 0 | 2 | 8.2 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL288600 | 11900 | 0 | None | - | 1 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 619 | 9 | 0 | 2 | 8.2 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
9871754 | 5337 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1016/j.bmc.2008.09.037 | ||
CHEMBL107172 | 5337 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1016/j.bmc.2008.09.037 | ||
9945487 | 206017 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 332 | 6 | 2 | 3 | 3.9 | FC(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL95852 | 206017 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 332 | 6 | 2 | 3 | 3.9 | FC(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
10268178 | 205925 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 324 | 6 | 2 | 3 | 4.1 | CC(C)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL95315 | 205925 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 324 | 6 | 2 | 3 | 4.1 | CC(C)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
2102 | 1166 | 17 | None | 6 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
5311057 | 1166 | 17 | None | 6 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL441225 | 1166 | 17 | None | 6 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
104943 | 55099 | 34 | None | 4 | 4 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL16192 | 55099 | 34 | None | 4 | 4 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)10097-X | ||
22879211 | 206402 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 339 | 6 | 2 | 4 | 3.3 | COc1ccc(N(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL98125 | 206402 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 339 | 6 | 2 | 4 | 3.3 | COc1ccc(N(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
44433393 | 167086 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 352 | 5 | 2 | 3 | 4.6 | COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2007.09.053 | ||
CHEMBL430170 | 167086 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 352 | 5 | 2 | 3 | 4.6 | COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2007.09.053 | ||
44433393 | 167086 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 352 | 5 | 2 | 3 | 4.6 | COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm1013693 | ||
CHEMBL430170 | 167086 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 352 | 5 | 2 | 3 | 4.6 | COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm1013693 | ||
2098 | 3638 | 31 | None | -1 | 11 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00012-2 | ||||
36511 | 3638 | 31 | None | -1 | 11 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00012-2 | ||||
3805 | 3638 | 31 | None | -1 | 11 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00012-2 | ||||
3835 | 3638 | 31 | None | -1 | 11 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00012-2 | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 11 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00012-2 | ||||
132846 | 96998 | 21 | None | 1 | 4 | Rat | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL1256740 | 96998 | 21 | None | 1 | 4 | Rat | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL27006 | 96998 | 21 | None | 1 | 4 | Rat | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
9968267 | 108069 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 350 | 5 | 2 | 3 | 4.2 | FC(F)(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL320220 | 108069 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 350 | 5 | 2 | 3 | 4.2 | FC(F)(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
10089212 | 4439 | 0 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 349 | 4 | 1 | 2 | 5.6 | C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL102157 | 4439 | 0 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 349 | 4 | 1 | 2 | 5.6 | C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 | 10.1016/S0960-894X(97)10118-4 | ||
10047566 | 164689 | 3 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1021/jm00008a003 | ||
CHEMBL422931 | 164689 | 3 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1021/jm00008a003 | ||
10650495 | 106935 | 0 | None | - | 1 | Guinea pig | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 559 | 8 | 2 | 4 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N | 10.1021/jm970499g | ||
CHEMBL318085 | 106935 | 0 | None | - | 1 | Guinea pig | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 559 | 8 | 2 | 4 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N | 10.1021/jm970499g | ||
11801327 | 9266 | 0 | None | - | 1 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 578 | 10 | 2 | 4 | 5.4 | COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL111295 | 9266 | 0 | None | - | 1 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 578 | 10 | 2 | 4 | 5.4 | COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
9871754 | 5337 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1016/j.bmc.2008.09.037 | ||
CHEMBL107172 | 5337 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1016/j.bmc.2008.09.037 | ||
135413536 | 444 | 80 | None | 3 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/acs.jmedchem.1c00793 | ||
230 | 444 | 80 | None | 3 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/acs.jmedchem.1c00793 | ||
3490 | 444 | 80 | None | 3 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/acs.jmedchem.1c00793 | ||
6918365 | 444 | 80 | None | 3 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/acs.jmedchem.1c00793 | ||
CHEMBL1471 | 444 | 80 | None | 3 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/acs.jmedchem.1c00793 | ||
DB00673 | 444 | 80 | None | 3 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/acs.jmedchem.1c00793 | ||
9832207 | 11894 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 662 | 8 | 1 | 3 | 7.1 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL1183274 | 11894 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 662 | 8 | 1 | 3 | 7.1 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL288123 | 11894 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 662 | 8 | 1 | 3 | 7.1 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
10817013 | 9166 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 577 | 9 | 3 | 4 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O | 10.1021/jm970499g | ||
CHEMBL110770 | 9166 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 577 | 9 | 3 | 4 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O | 10.1021/jm970499g | ||
44327794 | 110934 | 1 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 366 | 5 | 3 | 4 | 3.9 | Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL327357 | 110934 | 1 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 366 | 5 | 3 | 4 | 3.9 | Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(98)00012-2 | ||
CHEMBL2369600 | 207889 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm990461z | ||||
44286165 | 157849 | 0 | None | - | 1 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 646 | 8 | 0 | 4 | 8.3 | CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL1794935 | 157849 | 0 | None | - | 1 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 646 | 8 | 0 | 4 | 8.3 | CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL40900 | 157849 | 0 | None | - | 1 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 646 | 8 | 0 | 4 | 8.3 | CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL5074991 | 212578 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | None | None | None | C[C@@H](O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.1c00793 | ||||
10039383 | 85052 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 281 | 5 | 1 | 2 | 3.5 | c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 | 10.1021/jm00008a003 | ||
CHEMBL22680 | 85052 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 281 | 5 | 1 | 2 | 3.5 | c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 | 10.1021/jm00008a003 | ||
15542673 | 205830 | 0 | None | 1 | 2 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL94834 | 205830 | 0 | None | 1 | 2 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
44327909 | 111866 | 0 | None | 37 | 2 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 706 | 14 | 0 | 10 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL329450 | 111866 | 0 | None | 37 | 2 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 706 | 14 | 0 | 10 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL2304126 | 207735 | 0 | None | - | 1 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | None | None | None | COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 | 10.1021/jm00157a009 | ||||
9832306 | 112227 | 0 | None | -2 | 2 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 806 | 17 | 0 | 10 | 8.2 | CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL330367 | 112227 | 0 | None | -2 | 2 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 806 | 17 | 0 | 10 | 8.2 | CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL330462 | 112227 | 0 | None | -2 | 2 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 806 | 17 | 0 | 10 | 8.2 | CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC | 10.1016/S0960-894X(97)10097-X | ||
10123138 | 108039 | 0 | None | 1 | 2 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL317524 | 108039 | 0 | None | 1 | 2 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL320002 | 108039 | 0 | None | 1 | 2 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
10190842 | 106740 | 0 | None | 63 | 2 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 788 | 16 | 0 | 11 | 7.1 | COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL316705 | 106740 | 0 | None | 63 | 2 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 788 | 16 | 0 | 11 | 7.1 | COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10097-X | ||
44286051 | 11901 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 724 | 10 | 1 | 3 | 9.1 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL1183288 | 11901 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 724 | 10 | 1 | 3 | 9.1 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL288840 | 11901 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 724 | 10 | 1 | 3 | 9.1 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
44285793 | 99826 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 620 | 8 | 0 | 4 | 7.8 | CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL1201933 | 99826 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 620 | 8 | 0 | 4 | 7.8 | CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL289091 | 99826 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 620 | 8 | 0 | 4 | 7.8 | CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
44331794 | 4135 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 267 | 4 | 1 | 2 | 3.7 | c1ccc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL100178 | 4135 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 267 | 4 | 1 | 2 | 3.7 | c1ccc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL2369697 | 207905 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm990461z | ||||
10769060 | 5957 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 552 | 8 | 2 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 | 10.1021/jm970499g | ||
CHEMBL108040 | 5957 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 552 | 8 | 2 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 | 10.1021/jm970499g | ||
44285794 | 141269 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 652 | 8 | 0 | 4 | 7.5 | CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL38624 | 141269 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 652 | 8 | 0 | 4 | 7.5 | CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
44213067 | 11906 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 648 | 8 | 1 | 3 | 7.6 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL1183307 | 11906 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 648 | 8 | 1 | 3 | 7.6 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL289727 | 11906 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 648 | 8 | 1 | 3 | 7.6 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
10626666 | 108708 | 0 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 559 | 8 | 2 | 4 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 | 10.1021/jm970499g | ||
CHEMBL321554 | 108708 | 0 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 559 | 8 | 2 | 4 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 | 10.1021/jm970499g | ||
10602943 | 106934 | 0 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 559 | 8 | 2 | 4 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 | 10.1021/jm970499g | ||
CHEMBL318084 | 106934 | 0 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 559 | 8 | 2 | 4 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 | 10.1021/jm970499g | ||
10168749 | 205887 | 0 | None | 3 | 2 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 676 | 12 | 0 | 9 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL95127 | 205887 | 0 | None | 3 | 2 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 676 | 12 | 0 | 9 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
10745241 | 110042 | 0 | None | -1 | 2 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 549 | 8 | 3 | 4 | 4.8 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N | 10.1021/jm970499g | ||
CHEMBL325116 | 110042 | 0 | None | -1 | 2 | Guinea pig | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 549 | 8 | 3 | 4 | 4.8 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N | 10.1021/jm970499g | ||
CHEMBL2369696 | 207904 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm990461z | ||||
10234086 | 111144 | 0 | None | 6 | 2 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 744 | 13 | 0 | 10 | 6.7 | COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL328511 | 111144 | 0 | None | 6 | 2 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 744 | 13 | 0 | 10 | 6.7 | COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 | 10.1016/S0960-894X(97)10097-X | ||
10258866 | 16425 | 5 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 664 | 5 | 4 | 6 | 3.1 | O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 | 10.1016/0960-894X(95)00039-V | ||
CHEMBL124066 | 16425 | 5 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 664 | 5 | 4 | 6 | 3.1 | O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 | 10.1016/0960-894X(95)00039-V | ||
136035319 | 162747 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 446 | 6 | 2 | 5 | 5.3 | C[C@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL418800 | 162747 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 446 | 6 | 2 | 5 | 5.3 | C[C@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 | 10.1016/S0960-894X(97)10118-4 | ||
10027061 | 14783 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 456 | 4 | 1 | 3 | 5.3 | O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1016285 | ||
CHEMBL120844 | 14783 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 456 | 4 | 1 | 3 | 5.3 | O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1016285 | ||
CHEMBL2304029 | 207731 | 0 | None | - | 1 | Rat | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | None | None | None | COC(=O)[C@@H](CCSC)NC(=O)[C@@H](CC(C)C)SCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 | 10.1021/jm00157a009 | ||||
10122529 | 109068 | 0 | None | 3 | 2 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 668 | 14 | 0 | 9 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL322194 | 109068 | 0 | None | 3 | 2 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 668 | 14 | 0 | 9 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10097-X | ||
44349304 | 16797 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 468 | 5 | 3 | 5 | 2.9 | COc1ccc(N)cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 | 10.1016/0960-894X(95)00039-V | ||
CHEMBL125385 | 16797 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 468 | 5 | 3 | 5 | 2.9 | COc1ccc(N)cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 | 10.1016/0960-894X(95)00039-V | ||
10212645 | 13178 | 0 | None | 346 | 2 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 774 | 16 | 1 | 10 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL1191766 | 13178 | 0 | None | 346 | 2 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 774 | 16 | 1 | 10 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL542908 | 13178 | 0 | None | 346 | 2 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 774 | 16 | 1 | 10 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
15542881 | 112095 | 0 | None | 3 | 2 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL330172 | 112095 | 0 | None | 3 | 2 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
10233656 | 206115 | 0 | None | 3 | 2 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL96442 | 206115 | 0 | None | 3 | 2 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
10283825 | 96245 | 0 | None | 1 | 2 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 740 | 12 | 0 | 8 | 7.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL264007 | 96245 | 0 | None | 1 | 2 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 740 | 12 | 0 | 8 | 7.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
153996 | 112171 | 2 | None | 1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL330366 | 112171 | 2 | None | 1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL539021 | 112171 | 2 | None | 1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
10507650 | 162778 | 0 | None | - | 1 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 591 | 9 | 3 | 4 | 4.6 | CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL419004 | 162778 | 0 | None | - | 1 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 591 | 9 | 3 | 4 | 4.6 | CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
14986134 | 163281 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2017.06.056 | ||
CHEMBL4206396 | 163281 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2017.06.056 | ||
9918576 | 205606 | 0 | None | 2 | 3 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 764 | 14 | 0 | 10 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL93556 | 205606 | 0 | None | 2 | 3 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 764 | 14 | 0 | 10 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10097-X | ||
44286200 | 141321 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 633 | 8 | 1 | 4 | 7.4 | CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL38652 | 141321 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 633 | 8 | 1 | 4 | 7.4 | CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
10147107 | 205886 | 0 | None | 3 | 2 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 755 | 12 | 0 | 9 | 7.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL431850 | 205886 | 0 | None | 3 | 2 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 755 | 12 | 0 | 9 | 7.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL95125 | 205886 | 0 | None | 3 | 2 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 755 | 12 | 0 | 9 | 7.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL2304032 | 207732 | 0 | None | - | 1 | Rat | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | None | None | None | COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)SCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 | 10.1021/jm00157a009 | ||||
10212223 | 206399 | 0 | None | 2 | 2 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 704 | 12 | 0 | 8 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL431458 | 206399 | 0 | None | 2 | 2 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 704 | 12 | 0 | 8 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL98079 | 206399 | 0 | None | 2 | 2 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 704 | 12 | 0 | 8 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
9832207 | 11894 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 662 | 8 | 1 | 3 | 7.1 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL1183274 | 11894 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 662 | 8 | 1 | 3 | 7.1 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL288123 | 11894 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 662 | 8 | 1 | 3 | 7.1 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL5083565 | 213099 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | None | None | None | C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.1c00793 | ||||
10121390 | 112242 | 0 | None | 3 | 2 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 596 | 10 | 1 | 7 | 5.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL330499 | 112242 | 0 | None | 3 | 2 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 596 | 10 | 1 | 7 | 5.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
10123040 | 160548 | 0 | None | 7 | 2 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 730 | 13 | 1 | 9 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL411691 | 160548 | 0 | None | 7 | 2 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 730 | 13 | 1 | 9 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL537027 | 160548 | 0 | None | 7 | 2 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 730 | 13 | 1 | 9 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
15542879 | 112326 | 0 | None | 2 | 2 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL330719 | 112326 | 0 | None | 2 | 2 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
44349364 | 116331 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 468 | 5 | 3 | 5 | 2.9 | COc1ccc(N)cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 | 10.1016/0960-894X(95)00039-V | ||
CHEMBL337987 | 116331 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 468 | 5 | 3 | 5 | 2.9 | COc1ccc(N)cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 | 10.1016/0960-894X(95)00039-V | ||
10578261 | 9093 | 0 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 535 | 8 | 2 | 4 | 4.6 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 | 10.1021/jm970499g | ||
CHEMBL110301 | 9093 | 0 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 535 | 8 | 2 | 4 | 4.6 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 | 10.1021/jm970499g | ||
10360490 | 88311 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 349 | 5 | 1 | 2 | 4.8 | Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm00008a003 | ||
CHEMBL23617 | 88311 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 349 | 5 | 1 | 2 | 4.8 | Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm00008a003 | ||
44286038 | 11106 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 662 | 9 | 1 | 3 | 7.9 | CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL1178749 | 11106 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 662 | 9 | 1 | 3 | 7.9 | CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL39595 | 11106 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 662 | 9 | 1 | 3 | 7.9 | CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL2304118 | 207734 | 0 | None | - | 1 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O | 10.1021/jm00157a009 | ||||
10190413 | 205598 | 0 | None | 3 | 2 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 717 | 13 | 0 | 10 | 6.3 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL410270 | 205598 | 0 | None | 3 | 2 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 717 | 13 | 0 | 10 | 6.3 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL93519 | 205598 | 0 | None | 3 | 2 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 717 | 13 | 0 | 10 | 6.3 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 | 10.1016/S0960-894X(97)10097-X | ||
10417124 | 117976 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 678 | 5 | 4 | 6 | 3.4 | Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 | 10.1016/0960-894X(95)00039-V | ||
CHEMBL341365 | 117976 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 678 | 5 | 4 | 6 | 3.4 | Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 | 10.1016/0960-894X(95)00039-V | ||
44349370 | 116769 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 484 | 5 | 3 | 6 | 2.9 | O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@H]21 | 10.1016/0960-894X(95)00039-V | ||
CHEMBL339488 | 116769 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 484 | 5 | 3 | 6 | 2.9 | O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@H]21 | 10.1016/0960-894X(95)00039-V | ||
15542871 | 206119 | 0 | None | 1 | 2 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 726 | 9 | 0 | 7 | 8.0 | O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL96466 | 206119 | 0 | None | 1 | 2 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 726 | 9 | 0 | 7 | 8.0 | O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 | 10.1016/S0960-894X(97)10098-1 | ||
10530375 | 5553 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 534 | 8 | 2 | 3 | 5.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL107763 | 5553 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 534 | 8 | 2 | 3 | 5.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 | 10.1021/jm970499g | ||
10917690 | 205871 | 0 | None | 3 | 4 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 471 | 8 | 0 | 5 | 5.4 | COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL95051 | 205871 | 0 | None | 3 | 4 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 471 | 8 | 0 | 5 | 5.4 | COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
44328187 | 206398 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 456 | 7 | 0 | 5 | 5.6 | COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL98076 | 206398 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 456 | 7 | 0 | 5 | 5.6 | COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
135556923 | 106916 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 378 | 6 | 2 | 5 | 4.0 | C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL317979 | 106916 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 378 | 6 | 2 | 5 | 4.0 | C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)10118-4 | ||
9832306 | 112227 | 0 | None | -2 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 806 | 17 | 0 | 10 | 8.2 | CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL330367 | 112227 | 0 | None | -2 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 806 | 17 | 0 | 10 | 8.2 | CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL330462 | 112227 | 0 | None | -2 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 806 | 17 | 0 | 10 | 8.2 | CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL2304130 | 207737 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)O | 10.1021/jm00157a009 | ||||
10917690 | 205871 | 0 | None | -999 | 4 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 471 | 8 | 0 | 5 | 5.4 | COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL95051 | 205871 | 0 | None | -999 | 4 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 471 | 8 | 0 | 5 | 5.4 | COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1016/S0960-894X(97)10097-X | ||
44285795 | 96053 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 647 | 8 | 1 | 4 | 6.9 | CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL262540 | 96053 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 647 | 8 | 1 | 4 | 6.9 | CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
44349303 | 116716 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 498 | 6 | 2 | 6 | 3.2 | COc1ccc([N+](=O)[O-])cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 | 10.1016/0960-894X(95)00039-V | ||
CHEMBL339444 | 116716 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 498 | 6 | 2 | 6 | 3.2 | COc1ccc([N+](=O)[O-])cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 | 10.1016/0960-894X(95)00039-V | ||
CHEMBL2304129 | 207736 | 0 | None | - | 1 | Rat | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | None | None | None | COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 | 10.1021/jm00157a009 | ||||
10620143 | 98805 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 349 | 5 | 1 | 2 | 4.5 | FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm00008a003 | ||
CHEMBL281828 | 98805 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 349 | 5 | 1 | 2 | 4.5 | FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm00008a003 | ||
10327313 | 16698 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 692 | 5 | 4 | 6 | 3.7 | Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3cccc(C)c34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 | 10.1016/0960-894X(95)00039-V | ||
CHEMBL124979 | 16698 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 692 | 5 | 4 | 6 | 3.7 | Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3cccc(C)c34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 | 10.1016/0960-894X(95)00039-V | ||
15831290 | 146073 | 0 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 535 | 7 | 1 | 3 | 6.4 | CN(CC(CCN1CCC2(CC1)NCCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL39232 | 146073 | 0 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 535 | 7 | 1 | 3 | 6.4 | CN(CC(CCN1CCC2(CC1)NCCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 | 10.1016/s0960-894x(98)00260-1 | ||
10603544 | 110075 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 592 | 9 | 2 | 5 | 5.0 | COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL325312 | 110075 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 592 | 9 | 2 | 5 | 5.0 | COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
10190056 | 110950 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 674 | 11 | 0 | 7 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL327497 | 110950 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 674 | 11 | 0 | 7 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
44285857 | 11094 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 667 | 8 | 0 | 3 | 7.7 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL1178703 | 11094 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 667 | 8 | 0 | 3 | 7.7 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL38030 | 11094 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 667 | 8 | 0 | 3 | 7.7 | CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(98)00260-1 | ||
10190638 | 205808 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL94726 | 205808 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
10283825 | 96245 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 740 | 12 | 0 | 8 | 7.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL264007 | 96245 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 740 | 12 | 0 | 8 | 7.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
10283765 | 107601 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 730 | 12 | 0 | 8 | 7.4 | CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL319535 | 107601 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 730 | 12 | 0 | 8 | 7.4 | CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 | 10.1016/S0960-894X(97)10098-1 | ||
15542874 | 111677 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 786 | 12 | 0 | 8 | 8.7 | COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL329055 | 111677 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 786 | 12 | 0 | 8 | 8.7 | COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
10769059 | 108130 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 552 | 8 | 2 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 | 10.1021/jm970499g | ||
CHEMBL320581 | 108130 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 552 | 8 | 2 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 | 10.1021/jm970499g | ||
10123138 | 108039 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL317524 | 108039 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL320002 | 108039 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 748 | 12 | 0 | 10 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
15542673 | 205830 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL94834 | 205830 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
18333379 | 205841 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 686 | 15 | 0 | 9 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL94906 | 205841 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 686 | 15 | 0 | 9 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
10305069 | 206114 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 656 | 12 | 1 | 9 | 5.4 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL96441 | 206114 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 656 | 12 | 1 | 9 | 5.4 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL2304115 | 207733 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | None | None | None | COC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 | 10.1021/jm00157a009 | ||||
10190056 | 110950 | 0 | None | -1 | 2 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 674 | 11 | 0 | 7 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL327497 | 110950 | 0 | None | -1 | 2 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 674 | 11 | 0 | 7 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC | 10.1016/S0960-894X(97)10097-X | ||
10212725 | 97717 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 790 | 15 | 1 | 11 | 6.6 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL273915 | 97717 | 0 | None | -1 | 2 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 790 | 15 | 1 | 11 | 6.6 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
15542679 | 108040 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 664 | 10 | 1 | 7 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL320003 | 108040 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 664 | 10 | 1 | 7 | 6.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
9918576 | 205606 | 0 | None | 2 | 3 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 764 | 14 | 0 | 10 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL93556 | 205606 | 0 | None | 2 | 3 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 764 | 14 | 0 | 10 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10098-1 | ||
10190413 | 205598 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 717 | 13 | 0 | 10 | 6.3 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL410270 | 205598 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 717 | 13 | 0 | 10 | 6.3 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL93519 | 205598 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 717 | 13 | 0 | 10 | 6.3 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
44328188 | 111038 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 728 | 16 | 0 | 11 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL327888 | 111038 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 728 | 16 | 0 | 11 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
15542879 | 112326 | 0 | None | 2 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL330719 | 112326 | 0 | None | 2 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
10121390 | 112242 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 596 | 10 | 1 | 7 | 5.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL330499 | 112242 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 596 | 10 | 1 | 7 | 5.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
10123040 | 160548 | 0 | None | 7 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 730 | 13 | 1 | 9 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL411691 | 160548 | 0 | None | 7 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 730 | 13 | 1 | 9 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL537027 | 160548 | 0 | None | 7 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 730 | 13 | 1 | 9 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
10190770 | 206275 | 0 | None | 1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL330430 | 206275 | 0 | None | 1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL97357 | 206275 | 0 | None | 1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
10212223 | 206399 | 0 | None | 2 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 704 | 12 | 0 | 8 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL431458 | 206399 | 0 | None | 2 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 704 | 12 | 0 | 8 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL98079 | 206399 | 0 | None | 2 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 704 | 12 | 0 | 8 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
10147107 | 205886 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 755 | 12 | 0 | 9 | 7.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL431850 | 205886 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 755 | 12 | 0 | 9 | 7.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL95125 | 205886 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 755 | 12 | 0 | 9 | 7.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
18333241 | 206058 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 736 | 14 | 0 | 9 | 7.2 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL96141 | 206058 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 736 | 14 | 0 | 9 | 7.2 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
10233656 | 206115 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL96442 | 206115 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
10147218 | 106980 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 778 | 15 | 0 | 10 | 7.5 | CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL318369 | 106980 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 778 | 15 | 0 | 10 | 7.5 | CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
15542881 | 112095 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL330172 | 112095 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 687 | 12 | 0 | 9 | 6.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
44328321 | 167225 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 788 | 17 | 1 | 10 | 7.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL430471 | 167225 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 788 | 17 | 1 | 10 | 7.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
10122529 | 109068 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 668 | 14 | 0 | 9 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL322194 | 109068 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 668 | 14 | 0 | 9 | 5.9 | CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
10169609 | 205911 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 804 | 15 | 0 | 12 | 6.7 | COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL95243 | 205911 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 804 | 15 | 0 | 12 | 6.7 | COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
10234086 | 111144 | 0 | None | 6 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 744 | 13 | 0 | 10 | 6.7 | COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL328511 | 111144 | 0 | None | 6 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 744 | 13 | 0 | 10 | 6.7 | COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 | 10.1016/S0960-894X(97)10098-1 | ||
15542880 | 205773 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 705 | 12 | 0 | 9 | 6.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL94480 | 205773 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 705 | 12 | 0 | 9 | 6.4 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
10168749 | 205887 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 676 | 12 | 0 | 9 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL95127 | 205887 | 0 | None | 3 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 676 | 12 | 0 | 9 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
10305888 | 205821 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 750 | 14 | 1 | 9 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL94788 | 205821 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 750 | 14 | 1 | 9 | 7.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
44328320 | 205867 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 802 | 17 | 0 | 11 | 7.5 | COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL95029 | 205867 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 802 | 17 | 0 | 11 | 7.5 | COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 | 10.1016/S0960-894X(97)10098-1 | ||
10284042 | 206247 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 777 | 13 | 0 | 10 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL97240 | 206247 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 777 | 13 | 0 | 10 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
15542869 | 205875 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 720 | 15 | 0 | 10 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
CHEMBL95076 | 205875 | 0 | None | -1 | 2 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 720 | 15 | 0 | 10 | 6.6 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10098-1 | ||
9892984 | 143733 | 1 | None | - | 1 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 522 | 7 | 0 | 3 | 6.8 | CN(CC(CCN1CCC2(CC1)OCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 | 10.1016/s0960-894x(98)00260-1 | ||
CHEMBL39049 | 143733 | 1 | None | - | 1 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 522 | 7 | 0 | 3 | 6.8 | CN(CC(CCN1CCC2(CC1)OCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 | 10.1016/s0960-894x(98)00260-1 | ||
11801586 | 5392 | 0 | None | 1 | 2 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 591 | 9 | 3 | 4 | 5.2 | CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL107502 | 5392 | 0 | None | 1 | 2 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 591 | 9 | 3 | 4 | 5.2 | CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
14986135 | 162849 | 0 | None | -10 | 3 | Human | 4.1 | pIC50 | = | 4.1 | Functional | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2017.06.056 | ||
CHEMBL419500 | 162849 | 0 | None | -10 | 3 | Human | 4.1 | pIC50 | = | 4.1 | Functional | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/j.ejmech.2017.06.056 | ||
CHEMBL5078626 | 212800 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | None | None | None | C[C@@H](O[C@H]1OC[C@H](O)[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.1c00793 | ||||
44331786 | 107331 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 349 | 4 | 1 | 2 | 5.6 | C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL319212 | 107331 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 349 | 4 | 1 | 2 | 5.6 | C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 | 10.1016/S0960-894X(97)10118-4 | ||
44331715 | 4666 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 281 | 4 | 1 | 2 | 4.3 | C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL103657 | 4666 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 281 | 4 | 1 | 2 | 4.3 | C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)10118-4 | ||
44331792 | 106699 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 417 | 4 | 1 | 2 | 6.3 | C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
CHEMBL316486 | 106699 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 417 | 4 | 1 | 2 | 6.3 | C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)10118-4 | ||
44349375 | 114560 | 0 | None | - | 1 | Human | 4.1 | pIC50 | = | 4.1 | Functional | ChEMBL | 498 | 6 | 2 | 6 | 3.2 | COc1ccc([N+](=O)[O-])cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 | 10.1016/0960-894X(95)00039-V | ||
CHEMBL334304 | 114560 | 0 | None | - | 1 | Human | 4.1 | pIC50 | = | 4.1 | Functional | ChEMBL | 498 | 6 | 2 | 6 | 3.2 | COc1ccc([N+](=O)[O-])cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 | 10.1016/0960-894X(95)00039-V | ||
10063954 | 98279 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 309 | 5 | 1 | 2 | 4.1 | Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm00008a003 | ||
CHEMBL277918 | 98279 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 309 | 5 | 1 | 2 | 4.1 | Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm00008a003 | ||
10190770 | 206275 | 0 | None | 1 | 2 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL330430 | 206275 | 0 | None | 1 | 2 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
CHEMBL97357 | 206275 | 0 | None | 1 | 2 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 772 | 12 | 0 | 8 | 8.3 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10097-X | ||
44349369 | 16719 | 0 | None | - | 1 | Human | 4.0 | pIC50 | = | 4.0 | Functional | ChEMBL | 484 | 5 | 3 | 6 | 2.9 | O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@@H]21 | 10.1016/0960-894X(95)00039-V | ||
CHEMBL125093 | 16719 | 0 | None | - | 1 | Human | 4.0 | pIC50 | = | 4.0 | Functional | ChEMBL | 484 | 5 | 3 | 6 | 2.9 | O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@@H]21 | 10.1016/0960-894X(95)00039-V | ||
44407908 | 140027 | 0 | None | - | 0 | Human | 10.0 | pKd | = | 10 | Functional | ChEMBL | 687 | 9 | 1 | 7 | 4.7 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL381155 | 140027 | 0 | None | - | 0 | Human | 10.0 | pKd | = | 10 | Functional | ChEMBL | 687 | 9 | 1 | 7 | 4.7 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 | 10.1016/j.bmcl.2005.10.077 | ||
44408039 | 75151 | 0 | None | - | 0 | Human | 9.8 | pKd | = | 9.8 | Functional | ChEMBL | 569 | 8 | 2 | 5 | 4.9 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL204297 | 75151 | 0 | None | - | 0 | Human | 9.8 | pKd | = | 9.8 | Functional | ChEMBL | 569 | 8 | 2 | 5 | 4.9 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN | 10.1016/j.bmcl.2005.10.077 | ||
44408088 | 139295 | 0 | None | - | 0 | Human | 9.8 | pKd | = | 9.8 | Functional | ChEMBL | 639 | 9 | 1 | 6 | 5.3 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL379898 | 139295 | 0 | None | - | 0 | Human | 9.8 | pKd | = | 9.8 | Functional | ChEMBL | 639 | 9 | 1 | 6 | 5.3 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
44408089 | 139656 | 0 | None | - | 0 | Human | 9.8 | pKd | = | 9.8 | Functional | ChEMBL | 653 | 10 | 1 | 6 | 5.7 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL380449 | 139656 | 0 | None | - | 0 | Human | 9.8 | pKd | = | 9.8 | Functional | ChEMBL | 653 | 10 | 1 | 6 | 5.7 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
44408045 | 75254 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.2 | CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL204691 | 75254 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.2 | CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2005.10.077 | ||
104943 | 55099 | 34 | None | -4 | 4 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
CHEMBL16192 | 55099 | 34 | None | -4 | 4 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
3086681 | 2240 | 14 | None | - | 1 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 10.1021/jm950616c | ||
3510 | 2240 | 14 | None | - | 1 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 10.1021/jm950616c | ||
CHEMBL42407 | 2240 | 14 | None | - | 1 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 10.1021/jm950616c | ||
44370529 | 48794 | 0 | None | - | 0 | Guinea pig | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 643 | 10 | 3 | 7 | 3.0 | CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O | 10.1021/jm960213s | ||
CHEMBL156128 | 48794 | 0 | None | - | 0 | Guinea pig | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 643 | 10 | 3 | 7 | 3.0 | CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O | 10.1021/jm960213s | ||
44408040 | 74070 | 0 | None | - | 0 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 637 | 7 | 1 | 6 | 5.1 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL202627 | 74070 | 0 | None | - | 0 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 637 | 7 | 1 | 6 | 5.1 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
44407998 | 75147 | 0 | None | - | 0 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 639 | 10 | 1 | 6 | 5.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL204262 | 75147 | 0 | None | - | 0 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 639 | 10 | 1 | 6 | 5.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
44407971 | 140223 | 0 | None | - | 0 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 625 | 9 | 1 | 6 | 4.9 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL381822 | 140223 | 0 | None | - | 0 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 625 | 9 | 1 | 6 | 4.9 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
44370713 | 50759 | 0 | None | - | 0 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 653 | 13 | 4 | 7 | 3.2 | CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O | 10.1021/jm960213s | ||
CHEMBL157858 | 50759 | 0 | None | - | 0 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 653 | 13 | 4 | 7 | 3.2 | CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O | 10.1021/jm960213s | ||
44305816 | 162469 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 589 | 8 | 2 | 4 | 3.6 | CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 | 10.1016/S0960-894X(96)00604-X | ||
CHEMBL417572 | 162469 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 589 | 8 | 2 | 4 | 3.6 | CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 | 10.1016/S0960-894X(96)00604-X | ||
44408051 | 140696 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 635 | 7 | 1 | 6 | 5.6 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL382871 | 140696 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 635 | 7 | 1 | 6 | 5.6 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
21041073 | 138320 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 667 | 11 | 1 | 6 | 6.1 | C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL378156 | 138320 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 667 | 11 | 1 | 6 | 6.1 | C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
9829083 | 119634 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL351274 | 119634 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
2102 | 1166 | 17 | None | 6 | 2 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/S0960-894X(96)00604-X | ||
5311057 | 1166 | 17 | None | 6 | 2 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/S0960-894X(96)00604-X | ||
CHEMBL441225 | 1166 | 17 | None | 6 | 2 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/S0960-894X(96)00604-X | ||
44407906 | 74359 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 715 | 11 | 1 | 6 | 6.7 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL203064 | 74359 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 715 | 11 | 1 | 6 | 6.7 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
9874480 | 74424 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 661 | 9 | 3 | 4 | 6.1 | COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL203113 | 74424 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 661 | 9 | 3 | 4 | 6.1 | COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2005.10.077 | ||
44407907 | 75345 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 715 | 11 | 1 | 6 | 6.7 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL204764 | 75345 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 715 | 11 | 1 | 6 | 6.7 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
44408025 | 75562 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 653 | 10 | 1 | 6 | 5.7 | C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL204979 | 75562 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 653 | 10 | 1 | 6 | 5.7 | C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
44407917 | 96110 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 617 | 8 | 1 | 5 | 6.6 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL262989 | 96110 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 617 | 8 | 1 | 5 | 6.6 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 | 10.1016/j.bmcl.2005.10.077 | ||
44407903 | 140191 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 655 | 9 | 1 | 6 | 6.0 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL381778 | 140191 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 655 | 9 | 1 | 6 | 6.0 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 | 10.1016/j.bmcl.2005.10.077 | ||
44407902 | 75073 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 652 | 9 | 1 | 6 | 5.2 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL204114 | 75073 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 652 | 9 | 1 | 6 | 5.2 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 | 10.1016/j.bmcl.2005.10.077 | ||
44408046 | 140213 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 667 | 11 | 1 | 6 | 6.1 | C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL381814 | 140213 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 667 | 11 | 1 | 6 | 6.1 | C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
104943 | 55099 | 34 | None | -4 | 4 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
CHEMBL16192 | 55099 | 34 | None | -4 | 4 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
44407972 | 140225 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 653 | 9 | 1 | 6 | 5.7 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL381825 | 140225 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 653 | 9 | 1 | 6 | 5.7 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
44370530 | 48858 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 639 | 13 | 4 | 7 | 2.6 | CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O | 10.1021/jm960213s | ||
CHEMBL156186 | 48858 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 639 | 13 | 4 | 7 | 2.6 | CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O | 10.1021/jm960213s | ||
44307819 | 102123 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 725 | 12 | 0 | 6 | 6.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL304106 | 102123 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 725 | 12 | 0 | 6 | 6.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
44307677 | 168698 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 697 | 12 | 1 | 6 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL441252 | 168698 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 697 | 12 | 1 | 6 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
44307678 | 196998 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL57993 | 196998 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00340-2 | ||
44307757 | 201842 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 753 | 12 | 1 | 7 | 5.8 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL66441 | 201842 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 753 | 12 | 1 | 7 | 5.8 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
9874206 | 202075 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 640 | 10 | 0 | 5 | 7.0 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL68060 | 202075 | 0 | None | - | 0 | Guinea pig | 8.0 | pKd | = | 8 | Functional | ChEMBL | 640 | 10 | 0 | 5 | 7.0 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
57394644 | 68023 | 0 | None | - | 0 | Human | 7.0 | pKd | = | 7 | Functional | ChEMBL | 721 | 10 | 4 | 6 | 4.3 | COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 | 10.1016/j.ejmech.2011.08.042 | ||
CHEMBL1916633 | 68023 | 0 | None | - | 0 | Human | 7.0 | pKd | = | 7 | Functional | ChEMBL | 721 | 10 | 4 | 6 | 4.3 | COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 | 10.1016/j.ejmech.2011.08.042 | ||
10032981 | 106270 | 0 | None | - | 0 | Human | 7.0 | pKd | = | 7 | Functional | ChEMBL | 746 | 12 | 3 | 8 | 3.3 | COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 | 10.1021/jm00063a015 | ||
CHEMBL3144347 | 106270 | 0 | None | - | 0 | Human | 7.0 | pKd | = | 7 | Functional | ChEMBL | 746 | 12 | 3 | 8 | 3.3 | COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 | 10.1021/jm00063a015 | ||
10055415 | 106274 | 0 | None | -2 | 4 | Human | 7.0 | pKd | = | 7 | Functional | ChEMBL | 688 | 12 | 4 | 5 | 3.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144352 | 106274 | 0 | None | -2 | 4 | Human | 7.0 | pKd | = | 7 | Functional | ChEMBL | 688 | 12 | 4 | 5 | 3.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
118718516 | 114862 | 0 | None | - | 0 | Guinea pig | 7.0 | pKd | = | 7 | Functional | ChEMBL | 1599 | 27 | 12 | 16 | 2.8 | CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O | 10.1021/jm00053a001 | ||
CHEMBL3349687 | 114862 | 0 | None | - | 0 | Guinea pig | 7.0 | pKd | = | 7 | Functional | ChEMBL | 1599 | 27 | 12 | 16 | 2.8 | CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O | 10.1021/jm00053a001 | ||
9939040 | 4941 | 5 | None | - | 2 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 623 | 7 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1021/jm030786m | ||
CHEMBL105060 | 4941 | 5 | None | - | 2 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 623 | 7 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1021/jm030786m | ||
44307679 | 201823 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL66332 | 201823 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00340-2 | ||
44307820 | 201940 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 725 | 12 | 0 | 6 | 6.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL67171 | 201940 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 725 | 12 | 0 | 6 | 6.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
57391132 | 68024 | 0 | None | - | 0 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 599 | 10 | 3 | 6 | 2.6 | COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 | 10.1016/j.ejmech.2011.08.042 | ||
CHEMBL1916634 | 68024 | 0 | None | - | 0 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 599 | 10 | 3 | 6 | 2.6 | COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 | 10.1016/j.ejmech.2011.08.042 | ||
10395494 | 106272 | 0 | None | - | 0 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 788 | 12 | 3 | 8 | 4.5 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144349 | 106272 | 0 | None | - | 0 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 788 | 12 | 3 | 8 | 4.5 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
9832198 | 106273 | 0 | None | 1 | 4 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 788 | 15 | 4 | 8 | 3.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144351 | 106273 | 0 | None | 1 | 4 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 788 | 15 | 4 | 8 | 3.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
44384380 | 59511 | 0 | None | - | 0 | Guinea pig | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 933 | 21 | 8 | 8 | 6.1 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80692-7 | ||
CHEMBL172794 | 59511 | 0 | None | - | 0 | Guinea pig | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 933 | 21 | 8 | 8 | 6.1 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80692-7 | ||
44383617 | 155161 | 0 | None | - | 0 | Guinea pig | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 961 | 22 | 8 | 9 | 5.6 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)c1cnc(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80692-7 | ||
CHEMBL405167 | 155161 | 0 | None | - | 0 | Guinea pig | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 961 | 22 | 8 | 9 | 5.6 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)c1cnc(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80692-7 | ||
10395612 | 106265 | 0 | None | - | 0 | Human | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 814 | 18 | 3 | 7 | 5.7 | CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 | 10.1021/jm00063a015 | ||
CHEMBL3144339 | 106265 | 0 | None | - | 0 | Human | 4.9 | pKd | = | 4.9 | Functional | ChEMBL | 814 | 18 | 3 | 7 | 5.7 | CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 | 10.1021/jm00063a015 | ||
9801487 | 205270 | 0 | None | - | 1 | Guinea pig | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 406 | 5 | 1 | 3 | 4.8 | Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL91418 | 205270 | 0 | None | - | 1 | Guinea pig | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 406 | 5 | 1 | 3 | 4.8 | Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 | 10.1016/s0960-894x(01)00727-2 | ||
52937467 | 62194 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 820 | 14 | 7 | 7 | 3.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm1016285 | ||
CHEMBL1782141 | 62194 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 820 | 14 | 7 | 7 | 3.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm1016285 | ||
44307898 | 199788 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 767 | 12 | 0 | 7 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL60504 | 199788 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 767 | 12 | 0 | 7 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
10418001 | 106271 | 0 | None | - | 0 | Human | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 822 | 14 | 3 | 8 | 4.9 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144348 | 106271 | 0 | None | - | 0 | Human | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 822 | 14 | 3 | 8 | 4.9 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL439284 | 212083 | 18 | None | - | 0 | Human | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCN=C(N)N)C(N)=O | 10.1021/jm00063a015 | ||||
44307758 | 201862 | 0 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 697 | 12 | 1 | 6 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL66635 | 201862 | 0 | None | - | 0 | Guinea pig | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 697 | 12 | 1 | 6 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
57391133 | 68025 | 0 | None | - | 0 | Human | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 691 | 12 | 3 | 7 | 4.4 | COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 | 10.1016/j.ejmech.2011.08.042 | ||
CHEMBL1916635 | 68025 | 0 | None | - | 0 | Human | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 691 | 12 | 3 | 7 | 4.4 | COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 | 10.1016/j.ejmech.2011.08.042 | ||
10350454 | 106249 | 0 | None | 2 | 4 | Human | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 815 | 18 | 4 | 8 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144209 | 106249 | 0 | None | 2 | 4 | Human | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 815 | 18 | 4 | 8 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
10439730 | 106275 | 0 | None | -1 | 4 | Human | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 702 | 12 | 3 | 6 | 3.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144353 | 106275 | 0 | None | -1 | 4 | Human | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 702 | 12 | 3 | 6 | 3.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
44383164 | 165157 | 0 | None | - | 0 | Guinea pig | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 916 | 21 | 9 | 7 | 5.3 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1c[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80692-7 | ||
CHEMBL424567 | 165157 | 0 | None | - | 0 | Guinea pig | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 916 | 21 | 9 | 7 | 5.3 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1c[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80692-7 | ||
CHEMBL3349620 | 209700 | 8 | None | - | 0 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | None | None | None | CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00053a001 | ||||
118718517 | 114863 | 0 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 800 | 12 | 6 | 8 | 1.5 | CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O | 10.1021/jm00053a001 | ||
CHEMBL3349688 | 114863 | 0 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 800 | 12 | 6 | 8 | 1.5 | CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O | 10.1021/jm00053a001 | ||
44407901 | 139914 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 701 | 10 | 1 | 6 | 6.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL380928 | 139914 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 701 | 10 | 1 | 6 | 6.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
52937271 | 62192 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 515 | 5 | 1 | 3 | 3.8 | CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm1016285 | ||
CHEMBL1782139 | 62192 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 515 | 5 | 1 | 3 | 3.8 | CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm1016285 | ||
132837 | 2207 | 51 | None | 77 | 4 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/S0960-894X(96)00604-X | ||
9461 | 2207 | 51 | None | 77 | 4 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/S0960-894X(96)00604-X | ||
CHEMBL22870 | 2207 | 51 | None | 77 | 4 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/S0960-894X(96)00604-X | ||
52937273 | 62190 | 0 | None | - | 0 | Human | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 458 | 3 | 0 | 2 | 4.7 | CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1016285 | ||
CHEMBL1782137 | 62190 | 0 | None | - | 0 | Human | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 458 | 3 | 0 | 2 | 4.7 | CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1016285 | ||
10145229 | 9083 | 0 | None | - | 0 | Guinea pig | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 592 | 7 | 1 | 4 | 5.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL110219 | 9083 | 0 | None | - | 0 | Guinea pig | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 592 | 7 | 1 | 4 | 5.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
10349900 | 106267 | 0 | None | -3 | 4 | Human | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 716 | 13 | 3 | 7 | 2.8 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144343 | 106267 | 0 | None | -3 | 4 | Human | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 716 | 13 | 3 | 7 | 2.8 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
10350528 | 106251 | 0 | None | 1 | 4 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 831 | 18 | 4 | 9 | 4.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144210 | 106251 | 0 | None | 1 | 4 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 831 | 18 | 4 | 9 | 4.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
44384379 | 129125 | 0 | None | - | 0 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 933 | 21 | 8 | 8 | 6.1 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80692-7 | ||
CHEMBL367312 | 129125 | 0 | None | - | 0 | Guinea pig | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 933 | 21 | 8 | 8 | 6.1 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80692-7 | ||
CHEMBL170299 | 207100 | 0 | None | - | 0 | Guinea pig | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80692-7 | ||||
44408048 | 140028 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 667 | 9 | 1 | 6 | 6.1 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL381157 | 140028 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 667 | 9 | 1 | 6 | 6.1 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
10259370 | 106266 | 0 | None | - | 0 | Human | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 730 | 12 | 3 | 7 | 3.4 | CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 | 10.1021/jm00063a015 | ||
CHEMBL3144340 | 106266 | 0 | None | - | 0 | Human | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 730 | 12 | 3 | 7 | 3.4 | CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 | 10.1021/jm00063a015 | ||
10506928 | 119713 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL352102 | 119713 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
44383616 | 167998 | 0 | None | - | 0 | Guinea pig | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 917 | 21 | 8 | 8 | 5.6 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80692-7 | ||
CHEMBL435717 | 167998 | 0 | None | - | 0 | Guinea pig | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 917 | 21 | 8 | 8 | 5.6 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80692-7 | ||
10325464 | 119629 | 0 | None | - | 1 | Human | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL351236 | 119629 | 0 | None | - | 1 | Human | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
44307821 | 101644 | 0 | None | - | 0 | Guinea pig | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 767 | 12 | 0 | 7 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL302329 | 101644 | 0 | None | - | 0 | Guinea pig | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 767 | 12 | 0 | 7 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
44337201 | 108125 | 0 | None | - | 0 | Guinea pig | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 592 | 7 | 1 | 4 | 5.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL320548 | 108125 | 0 | None | - | 0 | Guinea pig | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 592 | 7 | 1 | 4 | 5.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
107686 | 3327 | 37 | None | -3 | 5 | Guinea pig | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80650-2 | ||
3522 | 3327 | 37 | None | -3 | 5 | Guinea pig | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80650-2 | ||
CHEMBL131171 | 3327 | 37 | None | -3 | 5 | Guinea pig | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80650-2 | ||
52937270 | 62191 | 0 | None | - | 0 | Human | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 501 | 5 | 2 | 3 | 3.4 | CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm1016285 | ||
CHEMBL1782138 | 62191 | 0 | None | - | 0 | Human | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 501 | 5 | 2 | 3 | 3.4 | CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm1016285 | ||
44408033 | 74423 | 0 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 540 | 6 | 1 | 4 | 5.6 | CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL203111 | 74423 | 0 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 540 | 6 | 1 | 4 | 5.6 | CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2005.10.077 | ||
44408047 | 96320 | 0 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 597 | 9 | 1 | 5 | 5.5 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL264660 | 96320 | 0 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 597 | 9 | 1 | 5 | 5.5 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C | 10.1016/j.bmcl.2005.10.077 | ||
15887537 | 108559 | 0 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 700 | 7 | 1 | 4 | 7.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL321270 | 108559 | 0 | None | - | 0 | Guinea pig | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 700 | 7 | 1 | 4 | 7.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
21121353 | 101003 | 0 | None | 16 | 4 | Human | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 625 | 14 | 4 | 7 | 2.0 | CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O | 10.1021/jm00063a015 | ||
CHEMBL297776 | 101003 | 0 | None | 16 | 4 | Human | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 625 | 14 | 4 | 7 | 2.0 | CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O | 10.1021/jm00063a015 | ||
57392804 | 67642 | 0 | None | - | 0 | Human | 10.3 | pKi | = | 10.3 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.0 | Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911965 | 67642 | 0 | None | - | 0 | Human | 10.3 | pKi | = | 10.3 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.0 | Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911967 | 67642 | 0 | None | - | 0 | Human | 10.3 | pKi | = | 10.3 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.0 | Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
57403249 | 71165 | 0 | None | - | 0 | Human | 10.2 | pKi | = | 10.2 | Functional | ChEMBL | 625 | 6 | 1 | 4 | 6.3 | Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911968 | 71165 | 0 | None | - | 0 | Human | 10.2 | pKi | = | 10.2 | Functional | ChEMBL | 625 | 6 | 1 | 4 | 6.3 | Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1962728 | 71165 | 0 | None | - | 0 | Human | 10.2 | pKi | = | 10.2 | Functional | ChEMBL | 625 | 6 | 1 | 4 | 6.3 | Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
57396275 | 67641 | 0 | None | - | 0 | Human | 10.1 | pKi | = | 10.1 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.3 | Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911964 | 67641 | 0 | None | - | 0 | Human | 10.1 | pKi | = | 10.1 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.3 | Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
52933155 | 67645 | 0 | None | - | 0 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 641 | 7 | 3 | 5 | 5.5 | Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2(CO)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911970 | 67645 | 0 | None | - | 0 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 641 | 7 | 3 | 5 | 5.5 | Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2(CO)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
57392804 | 67642 | 0 | None | - | 0 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.0 | Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911965 | 67642 | 0 | None | - | 0 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.0 | Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911967 | 67642 | 0 | None | - | 0 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.0 | Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
57396275 | 67641 | 0 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.3 | Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911964 | 67641 | 0 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.3 | Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
57392804 | 67642 | 0 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.0 | Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911965 | 67642 | 0 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.0 | Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911967 | 67642 | 0 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.0 | Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
57398076 | 67644 | 0 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.1 | Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911969 | 67644 | 0 | None | - | 0 | Human | 9.6 | pKi | = | 9.6 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.1 | Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
57396275 | 67641 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.3 | Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911964 | 67641 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.3 | Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
57396275 | 67641 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.3 | Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
CHEMBL1911964 | 67641 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 611 | 6 | 2 | 4 | 6.3 | Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.07.116 | ||
2096 | 3587 | 0 | None | 25 | 2 | Guinea pig | 7.1 | pA2 | = | 7.1 | Functional | Guide to Pharmacology | None | None | None | None | 1693780 | ||||
2096 | 3587 | 0 | None | 25 | 2 | Guinea pig | 7.1 | pA2 | = | 7.1 | Functional | Guide to Pharmacology | None | None | None | None | 1702895 | ||||
25078100 | 3587 | 0 | None | 25 | 2 | Guinea pig | 7.1 | pA2 | = | 7.1 | Functional | Guide to Pharmacology | None | None | None | None | 1693780 | ||||
25078100 | 3587 | 0 | None | 25 | 2 | Guinea pig | 7.1 | pA2 | = | 7.1 | Functional | Guide to Pharmacology | None | None | None | None | 1702895 | ||||
16131028 | 3588 | 0 | None | 112 | 2 | Guinea pig | 7.6 | pA2 | = | 7.6 | Functional | Guide to Pharmacology | None | None | None | None | 1693780 | ||||
16131028 | 3588 | 0 | None | 112 | 2 | Guinea pig | 7.6 | pA2 | = | 7.6 | Functional | Guide to Pharmacology | None | None | None | None | 1702895 | ||||
2097 | 3588 | 0 | None | 112 | 2 | Guinea pig | 7.6 | pA2 | = | 7.6 | Functional | Guide to Pharmacology | None | None | None | None | 1693780 | ||||
2097 | 3588 | 0 | None | 112 | 2 | Guinea pig | 7.6 | pA2 | = | 7.6 | Functional | Guide to Pharmacology | None | None | None | None | 1702895 | ||||
16131028 | 3588 | 0 | None | -112 | 2 | Rat | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | None | None | None | None | 1702895 | ||||
2097 | 3588 | 0 | None | -112 | 2 | Rat | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | None | None | None | None | 1702895 | ||||
2096 | 3587 | 0 | None | -25 | 2 | Rat | 5.6 | pEC50 | = | 5.6 | Functional | Guide to Pharmacology | None | None | None | None | 1702895 | ||||
25078100 | 3587 | 0 | None | -25 | 2 | Rat | 5.6 | pEC50 | = | 5.6 | Functional | Guide to Pharmacology | None | None | None | None | 1702895 | ||||
135413536 | 444 | 80 | None | -3 | 2 | Mongolian jird | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
230 | 444 | 80 | None | -3 | 2 | Mongolian jird | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
3490 | 444 | 80 | None | -3 | 2 | Mongolian jird | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
6918365 | 444 | 80 | None | -3 | 2 | Mongolian jird | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
CHEMBL1471 | 444 | 80 | None | -3 | 2 | Mongolian jird | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
DB00673 | 444 | 80 | None | -3 | 2 | Mongolian jird | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
30699 | 215969 | 0 | None | -1 | 14 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 423 | 7 | 2 | 8 | 0.5 | CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O | None | ||
10328936 | 1517 | 28 | None | 2 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | None | None | None | None | None | ||||
2086 | 1517 | 28 | None | 2 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | None | None | None | None | None | ||||
2955 | 1517 | 28 | None | 2 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | None | None | None | None | None | ||||
CHEMBL373569 | 1517 | 28 | None | 2 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | None | None | None | None | None | ||||
135413538 | 1649 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 614 | 7 | 3 | 7 | 4.4 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
4470 | 1649 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 614 | 7 | 3 | 7 | 4.4 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
7623 | 1649 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 614 | 7 | 3 | 7 | 4.4 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
CHEMBL1199324 | 1649 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 614 | 7 | 3 | 7 | 4.4 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
DB06717 | 1649 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 614 | 7 | 3 | 7 | 4.4 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
2096 | 3587 | 0 | None | -25 | 2 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | Guide to Pharmacology | None | None | None | None | 6208451 | ||||
25078100 | 3587 | 0 | None | -25 | 2 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | Guide to Pharmacology | None | None | None | None | 6208451 | ||||
2088 | 2146 | 0 | None | 1 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
45749 | 2146 | 0 | None | 1 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
2101 | 3641 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
155817436 | 2753 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
2092 | 2753 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
107686 | 3327 | 37 | None | -3 | 5 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 1281470 | ||
3522 | 3327 | 37 | None | -3 | 5 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 1281470 | ||
CHEMBL131171 | 3327 | 37 | None | -3 | 5 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 1281470 | ||
10328936 | 1517 | 28 | None | 2 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
2086 | 1517 | 28 | None | 2 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
2955 | 1517 | 28 | None | 2 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
CHEMBL373569 | 1517 | 28 | None | 2 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
3849 | 3145 | 0 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | None | None | None | None | 9243521 | ||||
135413538 | 1649 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 614 | 7 | 3 | 7 | 4.4 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10737756 | ||
4470 | 1649 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 614 | 7 | 3 | 7 | 4.4 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10737756 | ||
7623 | 1649 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 614 | 7 | 3 | 7 | 4.4 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10737756 | ||
CHEMBL1199324 | 1649 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 614 | 7 | 3 | 7 | 4.4 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10737756 | ||
DB06717 | 1649 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 614 | 7 | 3 | 7 | 4.4 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10737756 | ||
108167 | 2813 | 5 | None | -58 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | 619 | 9 | 0 | 2 | 8.2 | CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C | 8702757 | ||
2107 | 2813 | 5 | None | -58 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | 619 | 9 | 0 | 2 | 8.2 | CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C | 8702757 | ||
CHEMBL1178725 | 2813 | 5 | None | -58 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | 619 | 9 | 0 | 2 | 8.2 | CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C | 8702757 | ||
17268 | 3068 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
2094 | 3068 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
10349 | 2220 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | 575 | 8 | 1 | 6 | 5.7 | CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 11708932 | ||
9809077 | 2220 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | 575 | 8 | 1 | 6 | 5.7 | CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 11708932 | ||
CHEMBL4303434 | 2220 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | 575 | 8 | 1 | 6 | 5.7 | CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 11708932 | ||
3850 | 3430 | 0 | None | - | 1 | Human | 9.8 | pIC50 | = | 9.8 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
3086681 | 2240 | 14 | None | - | 1 | Human | 9.8 | pIC50 | = | 9.8 | Functional | Guide to Pharmacology | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 20533894 | ||
3510 | 2240 | 14 | None | - | 1 | Human | 9.8 | pIC50 | = | 9.8 | Functional | Guide to Pharmacology | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 20533894 | ||
CHEMBL42407 | 2240 | 14 | None | - | 1 | Human | 9.8 | pIC50 | = | 9.8 | Functional | Guide to Pharmacology | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 20533894 | ||
2110 | 2922 | 33 | None | -2041 | 3 | Human | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 9042606 | ||
219077 | 2922 | 33 | None | -2041 | 3 | Human | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 9042606 | ||
3480 | 2922 | 33 | None | -2041 | 3 | Human | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 9042606 | ||
CHEMBL346178 | 2922 | 33 | None | -2041 | 3 | Human | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 9042606 | ||
DB04872 | 2922 | 33 | None | -2041 | 3 | Human | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 9042606 | ||
2100 | 3640 | 0 | None | - | 1 | Human | 6.4 | pIC50 | None | 6.4 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
2091 | 2755 | 0 | None | -223 | 2 | Human | 6.5 | pIC50 | None | 6.5 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
2099 | 3639 | 0 | None | - | 1 | Human | 7.9 | pIC50 | None | 7.9 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
2103 | 1613 | 0 | None | - | 1 | Human | 7.9 | pIC50 | None | 7.9 | Functional | Guide to Pharmacology | None | None | None | None | 1378096 | ||||
6437864 | 1613 | 0 | None | - | 1 | Human | 7.9 | pIC50 | None | 7.9 | Functional | Guide to Pharmacology | None | None | None | None | 1378096 | ||||
132629 | 2206 | 10 | None | - | 1 | Human | 8.3 | pIC50 | None | 8.3 | Functional | Guide to Pharmacology | 508 | 6 | 1 | 2 | 5.7 | Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 | 8702757 | ||
2104 | 2206 | 10 | None | - | 1 | Human | 8.3 | pIC50 | None | 8.3 | Functional | Guide to Pharmacology | 508 | 6 | 1 | 2 | 5.7 | Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 | 8702757 | ||
CHEMBL24999 | 2206 | 10 | None | - | 1 | Human | 8.3 | pIC50 | None | 8.3 | Functional | Guide to Pharmacology | 508 | 6 | 1 | 2 | 5.7 | Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 | 8702757 | ||
168489 | 3067 | 0 | None | - | 1 | Human | 8.4 | pIC50 | None | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
2093 | 3067 | 0 | None | - | 1 | Human | 8.4 | pIC50 | None | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 8702757 | ||||
2109 | 4073 | 3 | None | - | 1 | Human | 9.9 | pIC50 | None | 9.9 | Functional | Guide to Pharmacology | 631 | 9 | 0 | 4 | 7.9 | N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C | 11408556 | ||
9852253 | 4073 | 3 | None | - | 1 | Human | 9.9 | pIC50 | None | 9.9 | Functional | Guide to Pharmacology | 631 | 9 | 0 | 4 | 7.9 | N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C | 11408556 | ||
CHEMBL129683 | 4073 | 3 | None | - | 1 | Human | 9.9 | pIC50 | None | 9.9 | Functional | Guide to Pharmacology | 631 | 9 | 0 | 4 | 7.9 | N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C | 11408556 | ||
132837 | 2207 | 51 | None | -83 | 4 | Rat | 6.3 | pIC50 | ~ | 6.3 | Functional | Guide to Pharmacology | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 7509807 | ||
9461 | 2207 | 51 | None | -83 | 4 | Rat | 6.3 | pIC50 | ~ | 6.3 | Functional | Guide to Pharmacology | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 7509807 | ||
CHEMBL22870 | 2207 | 51 | None | -83 | 4 | Rat | 6.3 | pIC50 | ~ | 6.3 | Functional | Guide to Pharmacology | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 7509807 |
Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
2098 | 3638 | 31 | None | 1 | 6 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000093v | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000093v | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000093v | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000093v | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000093v | ||||
CHEMBL384518 | 210581 | 9 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O | 10.1021/jm000093v | ||||
CHEMBL428532 | 211707 | 6 | None | - | 0 | Guinea pig | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O | 10.1021/jm00157a029 | ||||
44337561 | 96290 | 0 | None | - | 0 | Guinea pig | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 921 | 19 | 9 | 10 | -0.2 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm960154i | ||
CHEMBL264395 | 96290 | 0 | None | - | 0 | Guinea pig | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 921 | 19 | 9 | 10 | -0.2 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm960154i | ||
44308430 | 101793 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 921 | 19 | 9 | 10 | -0.2 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm00040a005 | ||
CHEMBL303222 | 101793 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 921 | 19 | 9 | 10 | -0.2 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm00040a005 | ||
CHEMBL2371799 | 208382 | 0 | None | - | 0 | Guinea pig | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O | 10.1021/jm00157a029 | ||||
CHEMBL263185 | 208816 | 4 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O | 10.1021/jm000093v | ||||
CHEMBL415159 | 211427 | 4 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O | 10.1021/jm000093v | ||||
44337560 | 109262 | 0 | None | - | 0 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 950 | 19 | 9 | 10 | 0.5 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm960154i | ||
CHEMBL323028 | 109262 | 0 | None | - | 0 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 950 | 19 | 9 | 10 | 0.5 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm960154i | ||
44337787 | 9077 | 0 | None | - | 0 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 907 | 19 | 9 | 10 | -0.6 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm960154i | ||
CHEMBL110177 | 9077 | 0 | None | - | 0 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 907 | 19 | 9 | 10 | -0.6 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm960154i | ||
44308431 | 163970 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 907 | 19 | 9 | 10 | -0.6 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm00040a005 | ||
CHEMBL421485 | 163970 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 907 | 19 | 9 | 10 | -0.6 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm00040a005 | ||
CHEMBL2371799 | 208382 | 0 | None | - | 0 | Guinea pig | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O | 10.1021/jm00157a029 | ||||
132629 | 2206 | 10 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 508 | 6 | 1 | 2 | 5.7 | Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 | 10.1021/np058114h | ||
2104 | 2206 | 10 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 508 | 6 | 1 | 2 | 5.7 | Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 | 10.1021/np058114h | ||
CHEMBL24999 | 2206 | 10 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 508 | 6 | 1 | 2 | 5.7 | Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 | 10.1021/np058114h | ||
CHEMBL422779 | 211565 | 0 | None | - | 0 | Guinea pig | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O | 10.1021/jm960154i | ||||
CHEMBL106184 | 206728 | 0 | None | - | 0 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN(CCCN)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O | 10.1021/jm960154i | ||||
108147 | 3526 | 29 | None | - | 3 | Guinea pig | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960154i | ||||
2127 | 3526 | 29 | None | - | 3 | Guinea pig | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960154i | ||||
CHEMBL106124 | 3526 | 29 | None | - | 3 | Guinea pig | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm960154i | ||||
CHEMBL428532 | 211707 | 6 | None | - | 0 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O | 10.1021/jm00157a029 | ||||
10843656 | 96374 | 0 | None | - | 0 | Guinea pig | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 1009 | 34 | 10 | 11 | -0.1 | CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O | 10.1021/jm960154i | ||
CHEMBL265115 | 96374 | 0 | None | - | 0 | Guinea pig | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 1009 | 34 | 10 | 11 | -0.1 | CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O | 10.1021/jm960154i | ||
44337775 | 162855 | 0 | None | - | 0 | Guinea pig | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 893 | 19 | 9 | 10 | -1.0 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm960154i | ||
CHEMBL419558 | 162855 | 0 | None | - | 0 | Guinea pig | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 893 | 19 | 9 | 10 | -1.0 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm960154i | ||
44337797 | 108527 | 0 | None | - | 0 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 936 | 19 | 9 | 10 | 0.1 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm960154i | ||
CHEMBL321228 | 108527 | 0 | None | - | 0 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 936 | 19 | 9 | 10 | 0.1 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm960154i | ||
44308550 | 101648 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 936 | 19 | 9 | 10 | 0.1 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm00040a005 | ||
CHEMBL302349 | 101648 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 936 | 19 | 9 | 10 | 0.1 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm00040a005 | ||
162673403 | 182467 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 3435 | 125 | 39 | 39 | 2.9 | CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC | 10.1016/j.bmcl.2020.127353 | ||
CHEMBL4794099 | 182467 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 3435 | 125 | 39 | 39 | 2.9 | CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC | 10.1016/j.bmcl.2020.127353 | ||
44337530 | 167334 | 0 | None | - | 0 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 964 | 19 | 9 | 10 | 0.9 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm960154i | ||
CHEMBL431243 | 167334 | 0 | None | - | 0 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 964 | 19 | 9 | 10 | 0.9 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O | 10.1021/jm960154i | ||
162651127 | 179701 | 0 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 2299 | 83 | 25 | 24 | 7.8 | CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC | 10.1016/j.bmcl.2020.127353 | ||
CHEMBL4750714 | 179701 | 0 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 2299 | 83 | 25 | 24 | 7.8 | CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC | 10.1016/j.bmcl.2020.127353 | ||
11238415 | 98797 | 0 | None | - | 0 | Human | 11.0 | pIC50 | = | 11 | Binding | ChEMBL | 566 | 5 | 1 | 2 | 7.8 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CBr)nc2ccccc2c1-c1ccccc1 | 10.1021/jm034219a | ||
CHEMBL281797 | 98797 | 0 | None | - | 0 | Human | 11.0 | pIC50 | = | 11 | Binding | ChEMBL | 566 | 5 | 1 | 2 | 7.8 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CBr)nc2ccccc2c1-c1ccccc1 | 10.1021/jm034219a | ||
11352855 | 96669 | 0 | None | - | 0 | Human | 11.0 | pIC50 | = | 11.0 | Binding | ChEMBL | 517 | 6 | 2 | 3 | 6.6 | CNCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
CHEMBL26761 | 96669 | 0 | None | - | 0 | Human | 11.0 | pIC50 | = | 11.0 | Binding | ChEMBL | 517 | 6 | 2 | 3 | 6.6 | CNCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
9821217 | 107244 | 17 | None | - | 0 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL319118 | 107244 | 17 | None | - | 0 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL3215877 | 107244 | 17 | None | - | 0 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
49863731 | 15157 | 0 | None | - | 3 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 1266 | 18 | 10 | 12 | 6.1 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm100157m | ||
CHEMBL1214024 | 15157 | 0 | None | - | 3 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 1266 | 18 | 10 | 12 | 6.1 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm100157m | ||
25129133 | 188300 | 0 | None | 102 | 5 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800389v | ||
CHEMBL507340 | 188300 | 0 | None | 102 | 5 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800389v | ||
25129133 | 188300 | 0 | None | 102 | 5 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL507340 | 188300 | 0 | None | 102 | 5 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
25129133 | 188300 | 0 | None | 102 | 5 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm100157m | ||
CHEMBL507340 | 188300 | 0 | None | 102 | 5 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm100157m | ||
46884430 | 8236 | 0 | None | - | 0 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 487 | 4 | 0 | 2 | 6.3 | C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1092755 | 8236 | 0 | None | - | 0 | Human | 10.9 | pIC50 | = | 10.9 | Binding | ChEMBL | 487 | 4 | 0 | 2 | 6.3 | C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
11852872 | 68285 | 0 | None | - | 0 | Human | 10.8 | pIC50 | = | 10.8 | Binding | ChEMBL | 531 | 8 | 2 | 8 | 2.3 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917864 | 68285 | 0 | None | - | 0 | Human | 10.8 | pIC50 | = | 10.8 | Binding | ChEMBL | 531 | 8 | 2 | 8 | 2.3 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
25027805 | 70678 | 0 | None | - | 0 | Human | 10.8 | pIC50 | = | 10.8 | Binding | ChEMBL | 561 | 4 | 1 | 3 | 4.8 | Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951813 | 70678 | 0 | None | - | 0 | Human | 10.8 | pIC50 | = | 10.8 | Binding | ChEMBL | 561 | 4 | 1 | 3 | 4.8 | Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
44178113 | 60935 | 0 | None | - | 3 | Human | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 1237 | 27 | 10 | 11 | 5.6 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766208 | 60935 | 0 | None | - | 3 | Human | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 1237 | 27 | 10 | 11 | 5.6 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
57391771 | 70676 | 0 | None | - | 0 | Human | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 547 | 4 | 1 | 3 | 4.2 | Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951810 | 70676 | 0 | None | - | 0 | Human | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 547 | 4 | 1 | 3 | 4.2 | Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
57395695 | 71278 | 0 | None | - | 0 | Human | 10.6 | pIC50 | = | 10.6 | Binding | ChEMBL | 559 | 10 | 2 | 8 | 3.1 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917866 | 71278 | 0 | None | - | 0 | Human | 10.6 | pIC50 | = | 10.6 | Binding | ChEMBL | 559 | 10 | 2 | 8 | 3.1 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963416 | 71278 | 0 | None | - | 0 | Human | 10.6 | pIC50 | = | 10.6 | Binding | ChEMBL | 559 | 10 | 2 | 8 | 3.1 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
87318292 | 125931 | 0 | None | - | 0 | Human | 10.6 | pIC50 | = | 10.6 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 5.6 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | nan | ||
CHEMBL3651897 | 125931 | 0 | None | - | 0 | Human | 10.6 | pIC50 | = | 10.6 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 5.6 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | nan | ||
67232184 | 125925 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 548 | 4 | 0 | 3 | 4.9 | CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 | nan | ||
CHEMBL3651891 | 125925 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 548 | 4 | 0 | 3 | 4.9 | CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 | nan | ||
73265457 | 125930 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 653 | 4 | 0 | 4 | 4.5 | CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
CHEMBL3651896 | 125930 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 653 | 4 | 0 | 4 | 4.5 | CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
11248796 | 161100 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 488 | 4 | 0 | 2 | 7.2 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 | 10.1021/jm034219a | ||
CHEMBL413027 | 161100 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 488 | 4 | 0 | 2 | 7.2 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 | 10.1021/jm034219a | ||
122182823 | 121547 | 0 | None | - | 0 | Mongolian jird | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 433 | 6 | 1 | 7 | 3.7 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596448 | 121547 | 0 | None | - | 0 | Mongolian jird | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 433 | 6 | 1 | 7 | 3.7 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2015.04.098 | ||
44433804 | 146262 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL392466 | 146262 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
73265450 | 125921 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 680 | 4 | 0 | 3 | 7.2 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL3651887 | 125921 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 680 | 4 | 0 | 3 | 7.2 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
73265453 | 125926 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 617 | 4 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | nan | ||
CHEMBL3651892 | 125926 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 617 | 4 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | nan | ||
57402264 | 70616 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 611 | 5 | 0 | 3 | 5.9 | CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951626 | 70616 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 611 | 5 | 0 | 3 | 5.9 | CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
57403992 | 70623 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 519 | 4 | 1 | 2 | 5.3 | Cc1cc(F)ccc1[C@H]1CN(C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951633 | 70623 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 519 | 4 | 1 | 2 | 5.3 | Cc1cc(F)ccc1[C@H]1CN(C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
73265456 | 125929 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 590 | 4 | 1 | 3 | 5.7 | CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
CHEMBL3651895 | 125929 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 590 | 4 | 1 | 3 | 5.7 | CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
9828716 | 71289 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 503 | 7 | 2 | 7 | 3.4 | CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917853 | 71289 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 503 | 7 | 2 | 7 | 3.4 | CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963487 | 71289 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 503 | 7 | 2 | 7 | 3.4 | CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
127944 | 120412 | 2 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL356062 | 120412 | 2 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL555572 | 120412 | 2 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2013.09.001 | ||
46881682 | 8013 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1091469 | 8013 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
46883879 | 7688 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 626 | 5 | 0 | 3 | 8.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089271 | 7688 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 626 | 5 | 0 | 3 | 8.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
57398784 | 70621 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 575 | 6 | 1 | 3 | 4.9 | CC(=O)NCC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951631 | 70621 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 575 | 6 | 1 | 3 | 4.9 | CC(=O)NCC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 | 10.1016/j.bmc.2011.11.048 | ||
57400919 | 71275 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 529 | 8 | 2 | 7 | 3.9 | CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917856 | 71275 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 529 | 8 | 2 | 7 | 3.9 | CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963413 | 71275 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 529 | 8 | 2 | 7 | 3.9 | CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
57397000 | 70677 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 563 | 4 | 2 | 4 | 4.3 | Cc1cc(F)ccc1[C@H]1CN(C(=O)C(=O)NO)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951811 | 70677 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 563 | 4 | 2 | 4 | 4.3 | Cc1cc(F)ccc1[C@H]1CN(C(=O)C(=O)NO)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
11621512 | 70620 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 629 | 5 | 0 | 3 | 6.0 | CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951630 | 70620 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 629 | 5 | 0 | 3 | 6.0 | CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
57397022 | 70622 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 533 | 4 | 1 | 2 | 5.6 | CNC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951632 | 70622 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 533 | 4 | 1 | 2 | 5.6 | CNC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 | 10.1016/j.bmc.2011.11.048 | ||
73265454 | 125927 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 646 | 5 | 1 | 4 | 6.3 | COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 | nan | ||
CHEMBL3651893 | 125927 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 646 | 5 | 1 | 4 | 6.3 | COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 | nan | ||
57400917 | 71303 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 474 | 6 | 1 | 7 | 3.2 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917852 | 71303 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 474 | 6 | 1 | 7 | 3.2 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963577 | 71303 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 474 | 6 | 1 | 7 | 3.2 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
135539114 | 206561 | 2 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 500 | 6 | 2 | 4 | 5.1 | O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1021/jm9506534 | ||
CHEMBL99055 | 206561 | 2 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 500 | 6 | 2 | 4 | 5.1 | O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1021/jm9506534 | ||
122182821 | 121545 | 0 | None | - | 0 | Mongolian jird | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 365 | 6 | 1 | 7 | 2.7 | COc1ccc(-n2cnnn2)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596446 | 121545 | 0 | None | - | 0 | Mongolian jird | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 365 | 6 | 1 | 7 | 2.7 | COc1ccc(-n2cnnn2)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2015.04.098 | ||
122182822 | 121546 | 0 | None | - | 0 | Mongolian jird | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 379 | 6 | 1 | 7 | 3.0 | COc1ccc(-n2nnnc2C)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596447 | 121546 | 0 | None | - | 0 | Mongolian jird | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 379 | 6 | 1 | 7 | 3.0 | COc1ccc(-n2nnnc2C)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2015.04.098 | ||
44433798 | 145153 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 643 | 5 | 0 | 3 | 6.4 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL391615 | 145153 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 643 | 5 | 0 | 3 | 6.4 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
44433797 | 145603 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 615 | 5 | 0 | 3 | 5.6 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL391964 | 145603 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 615 | 5 | 0 | 3 | 5.6 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
24752718 | 6465 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 542 | 5 | 0 | 5 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1082896 | 6465 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 542 | 5 | 0 | 5 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
135539114 | 206561 | 2 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 500 | 6 | 2 | 4 | 5.1 | O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1021/jm0311487 | ||
CHEMBL99055 | 206561 | 2 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 500 | 6 | 2 | 4 | 5.1 | O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1021/jm0311487 | ||
57398783 | 70619 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 615 | 5 | 0 | 3 | 5.7 | CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951629 | 70619 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 615 | 5 | 0 | 3 | 5.7 | CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
57391771 | 70676 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 547 | 4 | 1 | 3 | 4.2 | Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951810 | 70676 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 547 | 4 | 1 | 3 | 4.2 | Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
57395688 | 68283 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 490 | 6 | 1 | 8 | 3.4 | COC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917851 | 68283 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 490 | 6 | 1 | 8 | 3.4 | COC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
57390405 | 71277 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 545 | 9 | 2 | 8 | 2.7 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917865 | 71277 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 545 | 9 | 2 | 8 | 2.7 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963415 | 71277 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 545 | 9 | 2 | 8 | 2.7 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
57397483 | 71276 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 515 | 7 | 2 | 7 | 3.5 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917859 | 71276 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 515 | 7 | 2 | 7 | 3.5 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963414 | 71276 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 515 | 7 | 2 | 7 | 3.5 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
57400921 | 71264 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 557 | 7 | 2 | 7 | 3.9 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917860 | 71264 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 557 | 7 | 2 | 7 | 3.9 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963300 | 71264 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 557 | 7 | 2 | 7 | 3.9 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
57395693 | 71265 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 557 | 7 | 1 | 8 | 2.6 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917862 | 71265 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 557 | 7 | 1 | 8 | 2.6 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963301 | 71265 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 557 | 7 | 1 | 8 | 2.6 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
44456802 | 97001 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 476 | 4 | 1 | 2 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)NC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL270090 | 97001 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 476 | 4 | 1 | 2 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)NC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
16663280 | 97512 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 475 | 4 | 0 | 2 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL272649 | 97512 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 475 | 4 | 0 | 2 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
23653789 | 3530 | 19 | None | - | 2 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm400751p | ||
9280 | 3530 | 19 | None | - | 2 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm400751p | ||
CHEMBL447955 | 3530 | 19 | None | - | 2 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm400751p | ||
DB12973 | 3530 | 19 | None | - | 2 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm400751p | ||
46881727 | 5518 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 570 | 7 | 2 | 4 | 5.6 | C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1077241 | 5518 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 570 | 7 | 2 | 4 | 5.6 | C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
46881779 | 8365 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1093750 | 8365 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
24752568 | 8824 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
24752568 | 8824 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1097693 | 8824 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1097693 | 8824 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
52949827 | 17160 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 531 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257357 | 17160 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 531 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
25028925 | 90934 | 2 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 570 | 5 | 1 | 5 | 5.5 | Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 | 10.1021/jm400751p | ||
CHEMBL2402572 | 90934 | 2 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 570 | 5 | 1 | 5 | 5.5 | Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 | 10.1021/jm400751p | ||
16663280 | 97512 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 475 | 4 | 0 | 2 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
16663280 | 97512 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 475 | 4 | 0 | 2 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL272649 | 97512 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 475 | 4 | 0 | 2 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL272649 | 97512 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 475 | 4 | 0 | 2 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
23653789 | 3530 | 19 | None | - | 2 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm8016514 | ||
9280 | 3530 | 19 | None | - | 2 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm8016514 | ||
CHEMBL447955 | 3530 | 19 | None | - | 2 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm8016514 | ||
DB12973 | 3530 | 19 | None | - | 2 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm8016514 | ||
44444666 | 153850 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 506 | 5 | 1 | 2 | 6.5 | CC(C)NC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL398720 | 153850 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 506 | 5 | 1 | 2 | 6.5 | CC(C)NC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
127944 | 120412 | 2 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm0311487 | ||
CHEMBL356062 | 120412 | 2 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm0311487 | ||
CHEMBL555572 | 120412 | 2 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm0311487 | ||
46947062 | 17278 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257706 | 17278 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
57391807 | 70617 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 625 | 6 | 0 | 3 | 6.1 | CCc1ccccc1[C@H]1CN(C(=O)C2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951627 | 70617 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 625 | 6 | 0 | 3 | 6.1 | CCc1ccccc1[C@H]1CN(C(=O)C2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
24889113 | 7866 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 571 | 5 | 0 | 4 | 6.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090450 | 7866 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 571 | 5 | 0 | 4 | 6.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1204418 | 7866 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 571 | 5 | 0 | 4 | 6.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
52943848 | 17238 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257588 | 17238 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
73265455 | 125928 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 660 | 5 | 1 | 4 | 5.4 | CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
CHEMBL3651894 | 125928 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 660 | 5 | 1 | 4 | 5.4 | CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
2098 | 3638 | 31 | None | -2 | 6 | Guinea pig | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
36511 | 3638 | 31 | None | -2 | 6 | Guinea pig | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
3805 | 3638 | 31 | None | -2 | 6 | Guinea pig | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
3835 | 3638 | 31 | None | -2 | 6 | Guinea pig | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
CHEMBL235363 | 3638 | 31 | None | -2 | 6 | Guinea pig | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
135406581 | 31711 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 520 | 6 | 2 | 5 | 4.4 | O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 | 10.1021/jm980299k | ||
CHEMBL140745 | 31711 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 520 | 6 | 2 | 5 | 4.4 | O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 | 10.1021/jm980299k | ||
44433800 | 146256 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL392463 | 146256 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
44433803 | 146261 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL392465 | 146261 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
24752718 | 6465 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 542 | 5 | 0 | 5 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1082896 | 6465 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 542 | 5 | 0 | 5 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
46881820 | 7480 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 542 | 5 | 0 | 5 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1087695 | 7480 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 542 | 5 | 0 | 5 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
46881729 | 7857 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1090421 | 7857 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
46881779 | 8365 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1093750 | 8365 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
44444634 | 93667 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 463 | 4 | 0 | 2 | 6.0 | CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL249145 | 93667 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 463 | 4 | 0 | 2 | 6.0 | CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
24180495 | 154144 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 483 | 5 | 0 | 3 | 6.5 | C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL399668 | 154144 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 483 | 5 | 0 | 3 | 6.5 | C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
44444643 | 154362 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 574 | 5 | 0 | 3 | 6.2 | CC(=O)N1CCC(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL400848 | 154362 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 574 | 5 | 0 | 3 | 6.2 | CC(=O)N1CCC(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 | 10.1016/j.bmcl.2007.06.085 | ||
135406581 | 31711 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 520 | 6 | 2 | 5 | 4.4 | O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 | 10.1021/jm800219f | ||
CHEMBL140745 | 31711 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 520 | 6 | 2 | 5 | 4.4 | O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 | 10.1021/jm800219f | ||
73265452 | 125924 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 609 | 4 | 0 | 4 | 5.8 | CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
CHEMBL3651890 | 125924 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 609 | 4 | 0 | 4 | 5.8 | CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
11852872 | 68285 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 531 | 8 | 2 | 8 | 2.3 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917864 | 68285 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 531 | 8 | 2 | 8 | 2.3 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
57402266 | 70624 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 549 | 5 | 1 | 3 | 5.5 | CONC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951634 | 70624 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 549 | 5 | 1 | 3 | 5.5 | CONC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 | 10.1016/j.bmc.2011.11.048 | ||
73265451 | 125923 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 666 | 4 | 0 | 3 | 6.8 | CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | nan | ||
CHEMBL3651889 | 125923 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 666 | 4 | 0 | 3 | 6.8 | CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | nan | ||
11409185 | 98964 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 488 | 4 | 1 | 2 | 7.2 | Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
CHEMBL282853 | 98964 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 488 | 4 | 1 | 2 | 7.2 | Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
57402690 | 68282 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 510 | 7 | 1 | 8 | 2.6 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917850 | 68282 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 510 | 7 | 1 | 8 | 2.6 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
9917079 | 60837 | 33 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 619 | 5 | 1 | 3 | 7.6 | O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765508 | 60837 | 33 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 619 | 5 | 1 | 3 | 7.6 | O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 | 10.1016/j.bmc.2011.02.031 | ||
5752 | 3942 | 20 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1021/jm980299k | ||
6918331 | 3942 | 20 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1021/jm980299k | ||
CHEMBL522302 | 3942 | 20 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1021/jm980299k | ||
DB12436 | 3942 | 20 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1021/jm980299k | ||
71456209 | 78247 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 457 | 4 | 1 | 7 | 4.0 | COc1ccc(-n2nnnc2C(F)(F)F)cc1C1=CC2(CCCN[C@H]2c2ccccc2)OC1 | 10.1016/s0960-894x(02)00509-7 | ||
CHEMBL2112366 | 78247 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 457 | 4 | 1 | 7 | 4.0 | COc1ccc(-n2nnnc2C(F)(F)F)cc1C1=CC2(CCCN[C@H]2c2ccccc2)OC1 | 10.1016/s0960-894x(02)00509-7 | ||
46881729 | 7857 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1090421 | 7857 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
24750734 | 7931 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1090742 | 7931 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
24750888 | 8366 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 504 | 4 | 1 | 3 | 5.4 | C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1093751 | 8366 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 504 | 4 | 1 | 3 | 5.4 | C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
24752434 | 9045 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1099372 | 9045 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
52941351 | 17196 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 531 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257466 | 17196 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 531 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
57395691 | 71304 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 517 | 7 | 2 | 7 | 3.8 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917858 | 71304 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 517 | 7 | 2 | 7 | 3.8 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963578 | 71304 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 517 | 7 | 2 | 7 | 3.8 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
57400923 | 71279 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 545 | 8 | 1 | 8 | 2.6 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917867 | 71279 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 545 | 8 | 1 | 8 | 2.6 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963417 | 71279 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 545 | 8 | 1 | 8 | 2.6 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
10407571 | 167394 | 8 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
CHEMBL431690 | 167394 | 8 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
57397481 | 71310 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 517 | 8 | 2 | 7 | 3.8 | CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917855 | 71310 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 517 | 8 | 2 | 7 | 3.8 | CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963613 | 71310 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 517 | 8 | 2 | 7 | 3.8 | CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmc.2013.09.001 | ||
230 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmc.2013.09.001 | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmc.2013.09.001 | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmc.2013.09.001 | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmc.2013.09.001 | ||
11983278 | 165547 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 477 | 4 | 1 | 2 | 6.4 | C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL425956 | 165547 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 477 | 4 | 1 | 2 | 6.4 | C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmc.2013.09.001 | ||
11983278 | 165547 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 477 | 4 | 1 | 2 | 6.4 | C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL425956 | 165547 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 477 | 4 | 1 | 2 | 6.4 | C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.02.080 | ||
135449286 | 192586 | 2 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 502 | 6 | 2 | 5 | 4.3 | O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1021/jm950654w | ||
CHEMBL52330 | 192586 | 2 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 502 | 6 | 2 | 5 | 4.3 | O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1021/jm950654w | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm980299k | ||
230 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm980299k | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm980299k | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm980299k | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm980299k | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm980299k | ||
135485796 | 35024 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 516 | 6 | 2 | 6 | 5.2 | C[C@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm980299k | ||
CHEMBL143587 | 35024 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 516 | 6 | 2 | 6 | 5.2 | C[C@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm980299k | ||
135449286 | 192586 | 2 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 502 | 6 | 2 | 5 | 4.3 | O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1021/jm980299k | ||
CHEMBL52330 | 192586 | 2 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 502 | 6 | 2 | 5 | 4.3 | O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1021/jm980299k | ||
44407331 | 140682 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 557 | 10 | 3 | 6 | 3.9 | CS(=O)(=O)NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL382848 | 140682 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 557 | 10 | 3 | 6 | 3.9 | CS(=O)(=O)NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 | 10.1016/j.bmcl.2005.11.026 | ||
135413536 | 444 | 80 | None | - | 2 | Mongolian jird | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2015.04.098 | ||
230 | 444 | 80 | None | - | 2 | Mongolian jird | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2015.04.098 | ||
3490 | 444 | 80 | None | - | 2 | Mongolian jird | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2015.04.098 | ||
6918365 | 444 | 80 | None | - | 2 | Mongolian jird | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL1471 | 444 | 80 | None | - | 2 | Mongolian jird | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2015.04.098 | ||
DB00673 | 444 | 80 | None | - | 2 | Mongolian jird | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2015.04.098 | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2007.08.028 | ||
230 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2007.08.028 | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2007.08.028 | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2007.08.028 | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2007.08.028 | ||
44433799 | 88240 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 582 | 5 | 0 | 4 | 5.8 | Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL235882 | 88240 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 582 | 5 | 0 | 4 | 5.8 | Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 | 10.1016/j.bmcl.2007.08.028 | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2006.06.035 | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2006.06.044 | ||
230 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2006.06.035 | ||
230 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2006.06.044 | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2006.06.035 | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2006.06.044 | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2006.06.035 | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2006.06.044 | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2006.06.035 | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2006.06.044 | ||
135449286 | 192586 | 2 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 502 | 6 | 2 | 5 | 4.3 | O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL52330 | 192586 | 2 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 502 | 6 | 2 | 5 | 4.3 | O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1016/j.bmcl.2006.06.035 | ||
24888943 | 7865 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 571 | 5 | 0 | 3 | 7.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090438 | 7865 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 571 | 5 | 0 | 3 | 7.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
24750734 | 7931 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
24750734 | 7931 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1090742 | 7931 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1090742 | 7931 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
46881682 | 8013 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1091469 | 8013 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
52947645 | 17061 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 596 | 5 | 0 | 4 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256586 | 17061 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 596 | 5 | 0 | 4 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
52948590 | 17125 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257235 | 17125 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
24993313 | 186448 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 532 | 4 | 1 | 2 | 6.8 | CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 | 10.1021/jm8016514 | ||
CHEMBL490869 | 186448 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 532 | 4 | 1 | 2 | 6.8 | CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 | 10.1021/jm8016514 | ||
44444631 | 93666 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 445 | 4 | 0 | 2 | 5.8 | CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL249144 | 93666 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 445 | 4 | 0 | 2 | 5.8 | CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
44444637 | 94065 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 477 | 5 | 0 | 2 | 6.3 | CCC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL251577 | 94065 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 477 | 5 | 0 | 2 | 6.3 | CCC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
44444685 | 154234 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 515 | 5 | 0 | 3 | 6.9 | CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL400148 | 154234 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 515 | 5 | 0 | 3 | 6.9 | CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O | 10.1016/j.bmcl.2007.06.085 | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm0109558 | ||
230 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm0109558 | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm0109558 | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm0109558 | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm0109558 | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm0109558 | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm800219f | ||
230 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm800219f | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm800219f | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm800219f | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm800219f | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm800219f | ||
135547943 | 34204 | 21 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 516 | 6 | 2 | 5 | 4.8 | C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800219f | ||
CHEMBL142819 | 34204 | 21 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 516 | 6 | 2 | 5 | 4.8 | C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800219f | ||
135449286 | 192586 | 2 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 502 | 6 | 2 | 5 | 4.3 | O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1021/jm800219f | ||
CHEMBL52330 | 192586 | 2 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 502 | 6 | 2 | 5 | 4.3 | O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1021/jm800219f | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm990617v | ||
230 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm990617v | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm990617v | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm990617v | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm990617v | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm990617v | ||
42611207 | 124266 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 651 | 4 | 0 | 3 | 6.7 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL3642163 | 124266 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 651 | 4 | 0 | 3 | 6.7 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
57399171 | 68284 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 515 | 6 | 2 | 7 | 3.3 | CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)cc3c2OCC3)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917857 | 68284 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 515 | 6 | 2 | 7 | 3.3 | CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)cc3c2OCC3)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
57398782 | 70611 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 597 | 5 | 0 | 3 | 5.6 | CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951621 | 70611 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 597 | 5 | 0 | 3 | 5.6 | CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/s0960-894x(02)00563-2 | ||
230 | 444 | 80 | None | 50 | 2 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/s0960-894x(02)00563-2 | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/s0960-894x(02)00563-2 | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/s0960-894x(02)00563-2 | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/s0960-894x(02)00563-2 | ||
135539114 | 206561 | 2 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 500 | 6 | 2 | 4 | 5.1 | O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1021/jm9700171 | ||
CHEMBL99055 | 206561 | 2 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 500 | 6 | 2 | 4 | 5.1 | O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 | 10.1021/jm9700171 | ||
135419433 | 31580 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 466 | 6 | 2 | 6 | 4.3 | C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(F)cc(C(F)(F)F)c1 | 10.1021/jm980299k | ||
CHEMBL140626 | 31580 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 466 | 6 | 2 | 6 | 4.3 | C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(F)cc(C(F)(F)F)c1 | 10.1021/jm980299k | ||
44407427 | 140649 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 432 | 7 | 2 | 4 | 5.0 | FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL382803 | 140649 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 432 | 7 | 2 | 4 | 5.0 | FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 | 10.1016/j.bmcl.2005.11.026 | ||
44318589 | 162791 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 493 | 4 | 1 | 8 | 3.4 | COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL419119 | 162791 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 493 | 4 | 1 | 8 | 3.4 | COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
136094861 | 204095 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 590 | 6 | 2 | 11 | 3.2 | COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL83250 | 204095 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 590 | 6 | 2 | 11 | 3.2 | COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
136094863 | 106651 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 556 | 6 | 2 | 10 | 3.8 | COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3n[nH]c(O)n3)C2c2ccccc2)C1 | 10.1016/s0960-894x(02)00509-7 | ||
CHEMBL316141 | 106651 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 556 | 6 | 2 | 10 | 3.8 | COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3n[nH]c(O)n3)C2c2ccccc2)C1 | 10.1016/s0960-894x(02)00509-7 | ||
57393955 | 71253 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 585 | 7 | 1 | 8 | 3.4 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917863 | 71253 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 585 | 7 | 1 | 8 | 3.4 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963216 | 71253 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 585 | 7 | 1 | 8 | 3.4 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
46830287 | 7908 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 580 | 5 | 0 | 3 | 6.4 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090648 | 7908 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 580 | 5 | 0 | 3 | 6.4 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
24993314 | 170472 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 569 | 5 | 0 | 3 | 8.1 | CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O | 10.1021/jm8016514 | ||
CHEMBL445686 | 170472 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 569 | 5 | 0 | 3 | 8.1 | CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O | 10.1021/jm8016514 | ||
44444664 | 94042 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 492 | 5 | 1 | 2 | 6.1 | CCNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL251387 | 94042 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 492 | 5 | 1 | 2 | 6.1 | CCNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
73265449 | 123893 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 630 | 4 | 0 | 3 | 6.0 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 | nan | ||
CHEMBL3639507 | 123893 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 630 | 4 | 0 | 3 | 6.0 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 | nan | ||
10051762 | 81817 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 501 | 6 | 0 | 4 | 6.1 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21709 | 81817 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 501 | 6 | 0 | 4 | 6.1 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
44407513 | 73948 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 462 | 8 | 3 | 5 | 4.2 | OCC1CC2(c3ccccc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL202417 | 73948 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 462 | 8 | 3 | 5 | 4.2 | OCC1CC2(c3ccccc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 | 10.1016/j.bmcl.2005.11.026 | ||
10004377 | 110920 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 459 | 4 | 1 | 7 | 4.1 | COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCNC2c2ccccc2)C1 | 10.1016/s0960-894x(02)00509-7 | ||
CHEMBL327250 | 110920 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 459 | 4 | 1 | 7 | 4.1 | COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCNC2c2ccccc2)C1 | 10.1016/s0960-894x(02)00509-7 | ||
44325058 | 111960 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 539 | 6 | 1 | 8 | 4.7 | COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3c[nH]cn3)C2c2ccccc2)C1 | 10.1016/s0960-894x(02)00509-7 | ||
CHEMBL329828 | 111960 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 539 | 6 | 1 | 8 | 4.7 | COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3c[nH]cn3)C2c2ccccc2)C1 | 10.1016/s0960-894x(02)00509-7 | ||
CHEMBL1651026 | 207083 | 19 | None | - | 1 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O | 10.1016/j.bmc.2016.03.006 | ||||
CHEMBL1651026 | 207083 | 19 | None | - | 1 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O | 10.1016/j.bmc.2016.11.014 | ||||
57398785 | 70625 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 561 | 4 | 1 | 3 | 4.5 | CNC(=O)C(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951635 | 70625 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 561 | 4 | 1 | 3 | 4.5 | CNC(=O)C(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 | 10.1016/j.bmc.2011.11.048 | ||
24889113 | 7866 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 571 | 5 | 0 | 4 | 6.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090450 | 7866 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 571 | 5 | 0 | 4 | 6.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1204418 | 7866 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 571 | 5 | 0 | 4 | 6.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
46884518 | 7896 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 554 | 5 | 0 | 4 | 6.8 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090547 | 7896 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 554 | 5 | 0 | 4 | 6.8 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
46884467 | 7909 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 582 | 5 | 0 | 3 | 7.3 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090649 | 7909 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 582 | 5 | 0 | 3 | 7.3 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
24750734 | 7931 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1090742 | 7931 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
46884519 | 8009 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 582 | 5 | 0 | 4 | 7.4 | Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1091342 | 8009 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 582 | 5 | 0 | 4 | 7.4 | Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 | 10.1016/j.bmcl.2010.01.120 | ||
52943994 | 17650 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1258967 | 17650 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
24993955 | 183723 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 517 | 4 | 0 | 2 | 7.0 | CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 | 10.1021/jm8016514 | ||
CHEMBL484134 | 183723 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 517 | 4 | 0 | 2 | 7.0 | CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 | 10.1021/jm8016514 | ||
44444681 | 93937 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 501 | 5 | 0 | 3 | 6.7 | C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL250798 | 93937 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 501 | 5 | 0 | 3 | 6.7 | C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
44444688 | 154465 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 515 | 5 | 0 | 3 | 6.9 | CC1CC(=O)C=C1N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL401415 | 154465 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 515 | 5 | 0 | 3 | 6.9 | CC1CC(=O)C=C1N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
44444658 | 166511 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 478 | 4 | 1 | 2 | 5.7 | CNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL428933 | 166511 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 478 | 4 | 1 | 2 | 5.7 | CNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
45271306 | 193999 | 0 | None | 14 | 4 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 1438 | 33 | 14 | 16 | 3.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL556537 | 193999 | 0 | None | 14 | 4 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 1438 | 33 | 14 | 16 | 3.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
2098 | 3638 | 31 | None | 1 | 6 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm034219a | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm034219a | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm034219a | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm034219a | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm034219a | ||||
2098 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00109a034 | ||||
36511 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00109a034 | ||||
3805 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00109a034 | ||||
3835 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00109a034 | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00109a034 | ||||
2098 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
36511 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
3805 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
3835 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
44274207 | 78163 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 501 | 6 | 1 | 4 | 5.7 | Cc1ccc(-c2c(CCC(=O)N3CCC(O)(Cc4ccccc4)CC3)c3cc(Cl)ccc3n2C)cn1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21122 | 78163 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 501 | 6 | 1 | 4 | 5.7 | Cc1ccc(-c2c(CCC(=O)N3CCC(O)(Cc4ccccc4)CC3)c3cc(Cl)ccc3n2C)cn1 | 10.1016/s0960-894x(01)00183-4 | ||
10053419 | 82208 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 555 | 6 | 1 | 4 | 6.4 | Cn1c(-c2ccc(C(F)(F)F)cn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21792 | 82208 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 555 | 6 | 1 | 4 | 6.4 | Cn1c(-c2ccc(C(F)(F)F)cn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00183-4 | ||
44412226 | 168271 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 477 | 4 | 0 | 2 | 6.3 | C[C@@H](O[C@H]1CCC(=O)N(C)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL437878 | 168271 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 477 | 4 | 0 | 2 | 6.3 | C[C@@H](O[C@H]1CCC(=O)N(C)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
44433789 | 145601 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 583 | 5 | 0 | 3 | 5.2 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL391963 | 145601 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 583 | 5 | 0 | 3 | 5.2 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
44444646 | 93587 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 546 | 5 | 0 | 3 | 5.6 | C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2CCC(=O)N2C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL248748 | 93587 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 546 | 5 | 0 | 3 | 5.6 | C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2CCC(=O)N2C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
44444693 | 94061 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 516 | 5 | 0 | 3 | 5.8 | C[C@@H](O[C@@H]1CN(C2=CC(=O)N(C)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL251557 | 94061 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 516 | 5 | 0 | 3 | 5.8 | C[C@@H](O[C@@H]1CN(C2=CC(=O)N(C)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
44444650 | 154363 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 541 | 5 | 0 | 4 | 6.3 | Cc1cnc(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)cn1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL400849 | 154363 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 541 | 5 | 0 | 4 | 6.3 | Cc1cnc(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)cn1 | 10.1016/j.bmcl.2007.06.085 | ||
2098 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00085a015 | ||||
36511 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00085a015 | ||||
3805 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00085a015 | ||||
3835 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00085a015 | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00085a015 | ||||
2098 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00080a025 | ||||
36511 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00080a025 | ||||
3805 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00080a025 | ||||
3835 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00080a025 | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 6 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00080a025 | ||||
CHEMBL389652 | 210683 | 0 | None | 2 | 4 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800389v | ||||
44334114 | 4478 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 562 | 7 | 0 | 4 | 5.9 | CN(C(=O)CN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1)c1ccccc1 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL102382 | 4478 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 562 | 7 | 0 | 4 | 5.9 | CN(C(=O)CN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1)c1ccccc1 | 10.1016/s0960-894x(01)00616-3 | ||
44295002 | 155421 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 486 | 6 | 0 | 6 | 4.9 | FC(F)(F)c1cc(CO[C@H]2OCCN(Cn3cncn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
CHEMBL406136 | 155421 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 486 | 6 | 0 | 6 | 4.9 | FC(F)(F)c1cc(CO[C@H]2OCCN(Cn3cncn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
44407325 | 73017 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 406 | 6 | 2 | 4 | 4.5 | COc1ccc(OC(F)(F)F)cc1CNC1CCC2CCC1(c1ccccc1)N2 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL201362 | 73017 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 406 | 6 | 2 | 4 | 4.5 | COc1ccc(OC(F)(F)F)cc1CNC1CCC2CCC1(c1ccccc1)N2 | 10.1016/j.bmcl.2005.11.026 | ||
57390403 | 71311 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 503 | 6 | 1 | 7 | 3.3 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917861 | 71311 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 503 | 6 | 1 | 7 | 3.3 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963614 | 71311 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 503 | 6 | 1 | 7 | 3.3 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
46881728 | 5519 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 628 | 9 | 2 | 6 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1077242 | 5519 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 628 | 9 | 2 | 6 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
46881821 | 5524 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 570 | 7 | 2 | 4 | 5.6 | C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1077281 | 5524 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 570 | 7 | 2 | 4 | 5.6 | C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
46884516 | 7744 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 567 | 5 | 0 | 4 | 6.5 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089533 | 7744 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 567 | 5 | 0 | 4 | 6.5 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
42639650 | 187612 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 569 | 5 | 0 | 3 | 8.1 | C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
CHEMBL499004 | 187612 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 569 | 5 | 0 | 3 | 8.1 | C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
44444684 | 93848 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 515 | 5 | 0 | 3 | 7.0 | CC1=C(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CCC1=O | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL250390 | 93848 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 515 | 5 | 0 | 3 | 7.0 | CC1=C(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CCC1=O | 10.1016/j.bmcl.2007.06.085 | ||
44444695 | 94101 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 525 | 5 | 0 | 3 | 7.5 | C[C@@H](O[C@@H]1CN(C2=CC(=O)CC(C)(C)C2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL251768 | 94101 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 525 | 5 | 0 | 3 | 7.5 | C[C@@H](O[C@@H]1CN(C2=CC(=O)CC(C)(C)C2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
44274251 | 82749 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 535 | 6 | 0 | 4 | 6.5 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)n(C)c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21831 | 82749 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 535 | 6 | 0 | 4 | 6.5 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)n(C)c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
10053174 | 99048 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 545 | 6 | 0 | 4 | 6.2 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)n(C)c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL283318 | 99048 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 545 | 6 | 0 | 4 | 6.2 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)n(C)c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
44412207 | 139802 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 463 | 4 | 1 | 2 | 6.0 | C[C@@H](O[C@H]1CCC(=O)NC[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL380680 | 139802 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 463 | 4 | 1 | 2 | 6.0 | C[C@@H](O[C@H]1CCC(=O)NC[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
9821217 | 107244 | 17 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm980299k | ||
CHEMBL319118 | 107244 | 17 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm980299k | ||
CHEMBL3215877 | 107244 | 17 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm980299k | ||
9821217 | 107244 | 17 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL319118 | 107244 | 17 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL3215877 | 107244 | 17 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2005.11.026 | ||
57403991 | 70615 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 611 | 5 | 0 | 3 | 5.9 | CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3cccc(C)c3)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951625 | 70615 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 611 | 5 | 0 | 3 | 5.9 | CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3cccc(C)c3)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
44456522 | 158338 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 477 | 4 | 0 | 3 | 5.9 | C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL409520 | 158338 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 477 | 4 | 0 | 3 | 5.9 | C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
22885694 | 140915 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 560 | 7 | 0 | 3 | 6.8 | C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL384177 | 140915 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 560 | 7 | 0 | 3 | 6.8 | C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
24888772 | 7934 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 564 | 5 | 0 | 3 | 7.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090752 | 7934 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 564 | 5 | 0 | 3 | 7.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
24752434 | 9045 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1099372 | 9045 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
52947646 | 17063 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256588 | 17063 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
52942803 | 17064 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256589 | 17064 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
44444669 | 153881 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 520 | 4 | 1 | 2 | 6.9 | C[C@@H](O[C@@H]1CN(C(=O)NC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL398919 | 153881 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 520 | 4 | 1 | 2 | 6.9 | C[C@@H](O[C@@H]1CN(C(=O)NC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
10186401 | 98470 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 521 | 6 | 1 | 4 | 6.1 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)cnc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL279442 | 98470 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 521 | 6 | 1 | 4 | 6.1 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)cnc21 | 10.1016/s0960-894x(01)00182-2 | ||
24889114 | 7669 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 569 | 5 | 0 | 5 | 6.5 | Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089081 | 7669 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 569 | 5 | 0 | 5 | 6.5 | Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 | 10.1016/j.bmcl.2010.01.120 | ||
46884515 | 7743 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 553 | 5 | 1 | 3 | 6.5 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089532 | 7743 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 553 | 5 | 1 | 3 | 6.5 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
46884472 | 7913 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 580 | 5 | 0 | 3 | 6.4 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090653 | 7913 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 580 | 5 | 0 | 3 | 6.4 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
24993312 | 178773 | 10 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 475 | 4 | 1 | 2 | 6.7 | C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
CHEMBL473680 | 178773 | 10 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 475 | 4 | 1 | 2 | 6.7 | C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
44444638 | 155117 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 491 | 5 | 0 | 2 | 6.6 | CC(C)C(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL404855 | 155117 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 491 | 5 | 0 | 2 | 6.6 | CC(C)C(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 | 10.1016/j.bmcl.2007.06.085 | ||
3086681 | 2240 | 14 | None | 89125 | 3 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 10.1021/jm950616c | ||
3510 | 2240 | 14 | None | 89125 | 3 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 10.1021/jm950616c | ||
CHEMBL42407 | 2240 | 14 | None | 89125 | 3 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 10.1021/jm950616c | ||
44333730 | 107186 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 561 | 7 | 0 | 3 | 7.5 | CCC(=O)N(c1ccccc1)C1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL319046 | 107186 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 561 | 7 | 0 | 3 | 7.5 | CCC(=O)N(c1ccccc1)C1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00616-3 | ||
10098209 | 98632 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 520 | 6 | 1 | 3 | 6.7 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL280662 | 98632 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 520 | 6 | 1 | 3 | 6.7 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
57400915 | 71274 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 422 | 6 | 1 | 4 | 4.1 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917844 | 71274 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 422 | 6 | 1 | 4 | 4.1 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963412 | 71274 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 422 | 6 | 1 | 4 | 4.1 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
44416078 | 139608 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 544 | 8 | 1 | 4 | 6.9 | CCN(Cc1nc[nH]n1)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL380210 | 139608 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 544 | 8 | 1 | 4 | 6.9 | CCN(Cc1nc[nH]n1)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
16006943 | 140912 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 530 | 7 | 1 | 4 | 6.5 | C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2nc[nH]n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL384171 | 140912 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 530 | 7 | 1 | 4 | 6.5 | C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2nc[nH]n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
46884473 | 7707 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 565 | 5 | 0 | 4 | 6.6 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089397 | 7707 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 565 | 5 | 0 | 4 | 6.6 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
46883823 | 8347 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 586 | 5 | 1 | 4 | 6.0 | C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1093596 | 8347 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 586 | 5 | 1 | 4 | 6.0 | C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
52948931 | 17067 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 559 | 5 | 1 | 3 | 6.5 | CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256592 | 17067 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 559 | 5 | 1 | 3 | 6.5 | CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 | 10.1016/j.bmcl.2010.07.058 | ||
44444660 | 154109 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 516 | 4 | 0 | 3 | 5.7 | C[C@@H](O[C@@H]1CN(C(=O)N2CCOCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL399466 | 154109 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 516 | 4 | 0 | 3 | 5.7 | C[C@@H](O[C@@H]1CN(C(=O)N2CCOCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
44444685 | 154234 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 515 | 5 | 0 | 3 | 6.9 | CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL400148 | 154234 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 515 | 5 | 0 | 3 | 6.9 | CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O | 10.1016/j.bmcl.2007.06.085 | ||
44444692 | 154936 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 503 | 5 | 0 | 4 | 5.9 | C[C@@H](O[C@@H]1CN(C2=CC(=O)OC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL404001 | 154936 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 503 | 5 | 0 | 4 | 5.9 | C[C@@H](O[C@@H]1CN(C2=CC(=O)OC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
44593632 | 178192 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 420 | 5 | 2 | 4 | 4.6 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)OC2 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL468830 | 178192 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 420 | 5 | 2 | 4 | 4.6 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)OC2 | 10.1016/j.bmc.2008.06.047 | ||
44177570 | 60931 | 0 | None | 15 | 4 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 1219 | 27 | 10 | 10 | 6.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766204 | 60931 | 0 | None | 15 | 4 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 1219 | 27 | 10 | 10 | 6.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
10460917 | 163197 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 583 | 11 | 2 | 4 | 5.5 | O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL420543 | 163197 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 583 | 11 | 2 | 4 | 5.5 | O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm9700171 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm9700171 | ||
73352606 | 92541 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 323 | 5 | 0 | 3 | 4.0 | COc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL2441368 | 92541 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 323 | 5 | 0 | 3 | 4.0 | COc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 | 10.1016/j.bmc.2013.09.001 | ||
10460917 | 163197 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 583 | 11 | 2 | 4 | 5.5 | O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL420543 | 163197 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 583 | 11 | 2 | 4 | 5.5 | O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
57402689 | 68280 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 451 | 7 | 2 | 4 | 4.3 | CCNC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917845 | 68280 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 451 | 7 | 2 | 4 | 4.3 | CCNC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
23146876 | 70613 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 595 | 5 | 0 | 3 | 5.6 | CC(=O)N1CCC(C(=O)N2CCC(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C(c3ccccc3)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951623 | 70613 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 595 | 5 | 0 | 3 | 5.6 | CC(=O)N1CCC(C(=O)N2CCC(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C(c3ccccc3)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
44433802 | 146258 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL392464 | 146258 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
44433804 | 146262 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL392466 | 146262 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
22885615 | 79770 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 550 | 10 | 1 | 4 | 5.7 | COCCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL213538 | 79770 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 550 | 10 | 1 | 4 | 5.7 | COCCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
52947645 | 17061 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 596 | 5 | 0 | 4 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256586 | 17061 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 596 | 5 | 0 | 4 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
52947647 | 17065 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256590 | 17065 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
44233185 | 193154 | 0 | None | 47 | 4 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 1327 | 29 | 14 | 16 | 1.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL539193 | 193154 | 0 | None | 47 | 4 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 1327 | 29 | 14 | 16 | 1.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
57397021 | 70614 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 611 | 5 | 0 | 3 | 5.9 | CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(C)cc3)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951624 | 70614 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 611 | 5 | 0 | 3 | 5.9 | CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(C)cc3)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
46884471 | 7667 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 564 | 5 | 0 | 3 | 7.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089062 | 7667 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 564 | 5 | 0 | 3 | 7.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
24768572 | 7687 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 624 | 5 | 0 | 3 | 8.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089270 | 7687 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 624 | 5 | 0 | 3 | 8.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
24888942 | 7864 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 569 | 5 | 0 | 3 | 7.0 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090437 | 7864 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 569 | 5 | 0 | 3 | 7.0 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
46883824 | 8348 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 583 | 5 | 1 | 3 | 7.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1093597 | 8348 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 583 | 5 | 1 | 3 | 7.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44444640 | 93546 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 487 | 4 | 0 | 2 | 6.8 | C[C@@H](O[C@@H]1CN(C(=O)C(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL248545 | 93546 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 487 | 4 | 0 | 2 | 6.8 | C[C@@H](O[C@@H]1CN(C(=O)C(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
44444694 | 154287 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 525 | 5 | 0 | 3 | 7.5 | C[C@@H](O[C@@H]1CN(C2=CC(=O)C(C)(C)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL400393 | 154287 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 525 | 5 | 0 | 3 | 7.5 | C[C@@H](O[C@@H]1CN(C2=CC(=O)C(C)(C)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
9850771 | 119373 | 2 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL348976 | 119373 | 2 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
15253734 | 164797 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 563 | 10 | 2 | 4 | 4.8 | CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 | 10.1021/jm950616c | ||
CHEMBL423623 | 164797 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 563 | 10 | 2 | 4 | 4.8 | CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 | 10.1021/jm950616c | ||
46227362 | 200897 | 0 | None | 12 | 4 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL611926 | 200897 | 0 | None | 12 | 4 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
44274166 | 79841 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 528 | 7 | 1 | 4 | 6.2 | CC(=O)c1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL21385 | 79841 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 528 | 7 | 1 | 4 | 6.2 | CC(=O)c1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C | 10.1016/s0960-894x(01)00182-2 | ||
44412236 | 77785 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 503 | 4 | 1 | 5 | 6.0 | C[C@@H](O[C@H]1CCc2nnc(O)n2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL210365 | 77785 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 503 | 4 | 1 | 5 | 6.0 | C[C@@H](O[C@H]1CCc2nnc(O)n2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
22885699 | 80608 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 506 | 7 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CC[C@@H](N(C)CC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL215373 | 80608 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 506 | 7 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CC[C@@H](N(C)CC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
22885703 | 140894 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 520 | 7 | 1 | 3 | 5.9 | CNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL384112 | 140894 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 520 | 7 | 1 | 3 | 5.9 | CNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
44357006 | 13613 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 575 | 8 | 1 | 6 | 5.7 | C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm0109558 | ||
CHEMBL1195055 | 13613 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 575 | 8 | 1 | 6 | 5.7 | C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm0109558 | ||
CHEMBL553778 | 13613 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 575 | 8 | 1 | 6 | 5.7 | C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm0109558 | ||
44356378 | 25538 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 587 | 8 | 1 | 6 | 5.9 | C[C@@H](OC1OCCN(Cc2n[nH]nc2CN2CCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm0109558 | ||
CHEMBL135263 | 25538 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 587 | 8 | 1 | 6 | 5.9 | C[C@@H](OC1OCCN(Cc2n[nH]nc2CN2CCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm0109558 | ||
10480465 | 206673 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 484 | 6 | 1 | 4 | 5.8 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL99792 | 206673 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 484 | 6 | 1 | 4 | 5.8 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
9892852 | 83960 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL22194 | 83960 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
24785717 | 121591 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 464 | 6 | 0 | 3 | 6.4 | CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596492 | 121591 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 464 | 6 | 0 | 3 | 6.4 | CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2015.04.098 | ||
18669097 | 98943 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 495 | 7 | 1 | 3 | 6.6 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL282725 | 98943 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 495 | 7 | 1 | 3 | 6.6 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
57402692 | 71266 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 531 | 8 | 2 | 8 | 2.3 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917869 | 71266 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 531 | 8 | 2 | 8 | 2.3 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963302 | 71266 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 531 | 8 | 2 | 8 | 2.3 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
57402221 | 70679 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 561 | 4 | 1 | 3 | 4.8 | Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951814 | 70679 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 561 | 4 | 1 | 3 | 4.8 | Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.11.048 | ||
22885697 | 141140 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 546 | 7 | 1 | 3 | 6.5 | C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL385463 | 141140 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 546 | 7 | 1 | 3 | 6.5 | C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
44433394 | 146125 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 406 | 6 | 2 | 3 | 5.1 | COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL392368 | 146125 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 406 | 6 | 2 | 3 | 5.1 | COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00016a014 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00016a014 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00016a014 | ||
9892852 | 83960 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
CHEMBL22194 | 83960 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
10553959 | 187287 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
CHEMBL49638 | 187287 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00066a015 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00066a015 | ||
9796216 | 101773 | 13 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@@H]1CCCN[C@@H]1c1ccccc1 | 10.1016/S0960-894X(01)81021-0 | ||
CHEMBL303118 | 101773 | 13 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@@H]1CCCN[C@@H]1c1ccccc1 | 10.1016/S0960-894X(01)81021-0 | ||
44294293 | 187869 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 429 | 4 | 0 | 2 | 6.1 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL50270 | 187869 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 429 | 4 | 0 | 2 | 6.1 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
10098209 | 98632 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 520 | 6 | 1 | 3 | 6.7 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL280662 | 98632 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 520 | 6 | 1 | 3 | 6.7 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
57402265 | 70618 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 639 | 6 | 0 | 3 | 6.7 | CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C(C)C)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951628 | 70618 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 639 | 6 | 0 | 3 | 6.7 | CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C(C)C)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
44433797 | 145603 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 615 | 5 | 0 | 3 | 5.6 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL391964 | 145603 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 615 | 5 | 0 | 3 | 5.6 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
52948868 | 17066 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 559 | 5 | 1 | 3 | 6.5 | CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256591 | 17066 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 559 | 5 | 1 | 3 | 6.5 | CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 | 10.1016/j.bmcl.2010.07.058 | ||
46883879 | 7688 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 626 | 5 | 0 | 3 | 8.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089271 | 7688 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 626 | 5 | 0 | 3 | 8.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44593636 | 181038 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 432 | 5 | 2 | 3 | 5.4 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL477365 | 181038 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 432 | 5 | 2 | 3 | 5.4 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 | 10.1016/j.bmc.2008.06.047 | ||
11814040 | 78399 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 601 | 8 | 1 | 6 | 6.3 | C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN2CCCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm0109558 | ||
CHEMBL2112743 | 78399 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 601 | 8 | 1 | 6 | 6.3 | C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN2CCCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm0109558 | ||
9871891 | 5386 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 537 | 4 | 0 | 4 | 6.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL107482 | 5386 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 537 | 4 | 0 | 4 | 6.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C | 10.1021/jm00016a014 | ||
9871891 | 5386 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 537 | 4 | 0 | 4 | 6.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C | 10.1021/jm0311487 | ||
CHEMBL107482 | 5386 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 537 | 4 | 0 | 4 | 6.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C | 10.1021/jm0311487 | ||
11318556 | 93501 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.9 | CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
CHEMBL24829 | 93501 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.9 | CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
9871414 | 98540 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 521 | 6 | 1 | 4 | 6.1 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ncc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL279977 | 98540 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 521 | 6 | 1 | 4 | 6.1 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ncc21 | 10.1016/s0960-894x(01)00182-2 | ||
44274253 | 171711 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 564 | 6 | 1 | 3 | 6.8 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Br)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL447473 | 171711 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 564 | 6 | 1 | 3 | 6.8 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Br)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
10099787 | 103037 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 582 | 5 | 1 | 3 | 7.4 | CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL3085129 | 103037 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 582 | 5 | 1 | 3 | 7.4 | CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
10480465 | 206673 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 484 | 6 | 1 | 4 | 5.8 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
CHEMBL99792 | 206673 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 484 | 6 | 1 | 4 | 5.8 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
44412245 | 77603 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 503 | 4 | 1 | 5 | 6.0 | C[C@@H](O[C@H]1CCn2c(O)nnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL209657 | 77603 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 503 | 4 | 1 | 5 | 6.0 | C[C@@H](O[C@H]1CCn2c(O)nnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
44444689 | 93790 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 517 | 5 | 1 | 4 | 5.6 | C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL249938 | 93790 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 517 | 5 | 1 | 4 | 5.6 | C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
24755076 | 91152 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 408 | 6 | 2 | 5 | 3.4 | COc1ccc(OC(F)(F)F)cc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2COC[C@@H]12 | 10.1016/j.bmcl.2007.10.010 | ||
CHEMBL240706 | 91152 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 408 | 6 | 2 | 5 | 3.4 | COc1ccc(OC(F)(F)F)cc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2COC[C@@H]12 | 10.1016/j.bmcl.2007.10.010 | ||
44412445 | 77566 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 477 | 4 | 1 | 2 | 6.2 | C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CNC1=O | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL209456 | 77566 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 477 | 4 | 1 | 2 | 6.2 | C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CNC1=O | 10.1016/j.bmcl.2006.02.080 | ||
135405092 | 138753 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 546 | 7 | 2 | 5 | 6.2 | C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2n[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL379137 | 138753 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 546 | 7 | 2 | 5 | 6.2 | C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2n[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
3086681 | 2240 | 14 | None | 89125 | 3 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 10.1016/s0960-894x(01)00250-5 | ||
3510 | 2240 | 14 | None | 89125 | 3 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL42407 | 2240 | 14 | None | 89125 | 3 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 10.1016/s0960-894x(01)00250-5 | ||
10257218 | 24635 | 2 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL134500 | 24635 | 2 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
10460917 | 163197 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 583 | 11 | 2 | 4 | 5.5 | O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL420543 | 163197 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 583 | 11 | 2 | 4 | 5.5 | O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
9871754 | 5337 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
CHEMBL107172 | 5337 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
10101238 | 34618 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 528 | 7 | 0 | 3 | 5.9 | O=C(CN1CCCC1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL143156 | 34618 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 528 | 7 | 0 | 3 | 5.9 | O=C(CN1CCCC1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL1651026 | 207083 | 19 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O | 10.1016/j.bmc.2013.03.016 | ||||
44407370 | 74102 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 11 | 3 | 6 | 5.4 | O=S(=O)(NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1)c1ccccc1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL202775 | 74102 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 11 | 3 | 6 | 5.4 | O=S(=O)(NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1)c1ccccc1 | 10.1016/j.bmcl.2005.11.026 | ||
22885698 | 138815 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 520 | 8 | 1 | 3 | 6.1 | CCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL379289 | 138815 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 520 | 8 | 1 | 3 | 6.1 | CCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
44444629 | 93665 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 449 | 5 | 0 | 2 | 5.6 | C[C@@H](O[C@@H]1CN(C=O)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL249143 | 93665 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 449 | 5 | 0 | 2 | 5.6 | C[C@@H](O[C@@H]1CN(C=O)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
9871754 | 5337 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm990220r | ||
CHEMBL107172 | 5337 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm990220r | ||
5757 | 3923 | 10 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1016/j.bmc.2013.09.001 | ||
9832383 | 3923 | 10 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL522987 | 3923 | 10 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1016/j.bmc.2013.09.001 | ||
DB11949 | 3923 | 10 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1016/j.bmc.2013.09.001 | ||
58993578 | 121592 | 0 | None | - | 0 | Mongolian jird | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 478 | 7 | 0 | 3 | 6.8 | CCN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596493 | 121592 | 0 | None | - | 0 | Mongolian jird | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 478 | 7 | 0 | 3 | 6.8 | CCN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2015.04.098 | ||
9891865 | 79647 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 493 | 8 | 1 | 3 | 6.5 | COCCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL212991 | 79647 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 493 | 8 | 1 | 3 | 6.5 | COCCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
22885692 | 79768 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 449 | 5 | 1 | 2 | 6.5 | CN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL213515 | 79768 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 449 | 5 | 1 | 2 | 6.5 | CN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
44415869 | 80281 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 546 | 7 | 1 | 3 | 6.5 | C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL215147 | 80281 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 546 | 7 | 1 | 3 | 6.5 | C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
22885691 | 80904 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 463 | 6 | 1 | 2 | 6.9 | CCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL215889 | 80904 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 463 | 6 | 1 | 2 | 6.9 | CCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
10951720 | 78397 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 547 | 7 | 2 | 6 | 5.1 | C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm0109558 | ||
CHEMBL2112741 | 78397 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 547 | 7 | 2 | 6 | 5.1 | C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm0109558 | ||
10369373 | 161411 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 519 | 4 | 0 | 4 | 5.9 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cccnc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL415705 | 161411 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 519 | 4 | 0 | 4 | 5.9 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cccnc2c(=O)n1C | 10.1021/jm00016a014 | ||
24992986 | 183722 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 489 | 4 | 0 | 2 | 7.1 | C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
CHEMBL484133 | 183722 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 489 | 4 | 0 | 2 | 7.1 | C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
44294659 | 103039 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 624 | 6 | 1 | 3 | 8.3 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCC(C3CCOC3(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL3085131 | 103039 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 624 | 6 | 1 | 3 | 8.3 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCC(C3CCOC3(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
9869697 | 64310 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 478 | 8 | 1 | 5 | 4.3 | COc1ccc(NS(C)(=O)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817895 | 64310 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 478 | 8 | 1 | 5 | 4.3 | COc1ccc(NS(C)(=O)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
10341570 | 120561 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL357012 | 120561 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
2098 | 3638 | 31 | None | 1 | 6 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00582-E | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00582-E | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00582-E | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00582-E | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00582-E | ||||
44274153 | 77527 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 512 | 7 | 1 | 3 | 6.7 | C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL20937 | 77527 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 512 | 7 | 1 | 3 | 6.7 | C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C | 10.1016/s0960-894x(01)00182-2 | ||
135529973 | 120996 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 448 | 6 | 2 | 6 | 4.2 | C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cccc(C(F)(F)F)c1 | 10.1021/jm980299k | ||
CHEMBL358343 | 120996 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 448 | 6 | 2 | 6 | 4.2 | C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cccc(C(F)(F)F)c1 | 10.1021/jm980299k | ||
44407459 | 140580 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 633 | 10 | 3 | 7 | 4.9 | O=C(NS(=O)(=O)c1ccccc1)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL382720 | 140580 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 633 | 10 | 3 | 7 | 4.9 | O=C(NS(=O)(=O)c1ccccc1)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 | 10.1016/j.bmcl.2005.11.026 | ||
44456524 | 97489 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 459 | 4 | 0 | 3 | 5.8 | C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL272569 | 97489 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 459 | 4 | 0 | 3 | 5.8 | C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
44416008 | 80091 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 557 | 7 | 1 | 3 | 6.7 | C[C@@H](O[C@H]1CC[C@@H](N(C)C(=O)Cc2c[nH]cn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL214748 | 80091 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 557 | 7 | 1 | 3 | 6.7 | C[C@@H](O[C@H]1CC[C@@H](N(C)C(=O)Cc2c[nH]cn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
46884470 | 7912 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 580 | 5 | 1 | 3 | 6.5 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090652 | 7912 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 580 | 5 | 1 | 3 | 6.5 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
24752568 | 8824 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1097693 | 8824 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
18407037 | 161709 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 521 | 6 | 0 | 4 | 6.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL416372 | 161709 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 521 | 6 | 0 | 4 | 6.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00616-3 | ||
18407037 | 161709 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 521 | 6 | 0 | 4 | 6.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL416372 | 161709 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 521 | 6 | 0 | 4 | 6.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
44412173 | 77858 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 486 | 4 | 0 | 3 | 6.9 | C[C@@H](O[C@H]1CCc2nccn2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL210630 | 77858 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 486 | 4 | 0 | 3 | 6.9 | C[C@@H](O[C@H]1CCc2nccn2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
44456700 | 95463 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 551 | 5 | 1 | 4 | 6.7 | C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL259251 | 95463 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 551 | 5 | 1 | 4 | 6.7 | C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
44415789 | 141133 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 564 | 9 | 1 | 4 | 5.6 | C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)CCO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL385414 | 141133 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 564 | 9 | 1 | 4 | 5.6 | C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)CCO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
10144275 | 18705 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 559 | 3 | 0 | 4 | 6.7 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
CHEMBL128369 | 18705 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 559 | 3 | 0 | 4 | 6.7 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
22293490 | 100840 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 636 | 7 | 2 | 3 | 7.8 | O=C(NC(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL296583 | 100840 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 636 | 7 | 2 | 3 | 7.8 | O=C(NC(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
24785717 | 121591 | 0 | None | - | 0 | Mongolian jird | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 464 | 6 | 0 | 3 | 6.4 | CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596492 | 121591 | 0 | None | - | 0 | Mongolian jird | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 464 | 6 | 0 | 3 | 6.4 | CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2015.04.098 | ||
44356404 | 23005 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 561 | 8 | 2 | 6 | 5.4 | CNCc1n[nH]nc1CN1CCOC(O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1 | 10.1021/jm0109558 | ||
CHEMBL133140 | 23005 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 561 | 8 | 2 | 6 | 5.4 | CNCc1n[nH]nc1CN1CCOC(O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1 | 10.1021/jm0109558 | ||
18669091 | 4617 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 505 | 6 | 0 | 3 | 6.4 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL103367 | 4617 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 505 | 6 | 0 | 3 | 6.4 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
10008129 | 60752 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 567 | 11 | 2 | 3 | 6.3 | O=C(CCCN1CCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL176500 | 60752 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 567 | 11 | 2 | 3 | 6.3 | O=C(CCCN1CCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
9938284 | 100945 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 584 | 5 | 1 | 4 | 6.6 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CC2)OCCO3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL297344 | 100945 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 584 | 5 | 1 | 4 | 6.6 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CC2)OCCO3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
11755227 | 201387 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 488 | 6 | 0 | 3 | 5.5 | CN(C)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL63793 | 201387 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 488 | 6 | 0 | 3 | 5.5 | CN(C)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
71450870 | 78249 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 407 | 4 | 1 | 4 | 5.0 | COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN[C@H]2c2ccccc2)C1 | 10.1016/s0960-894x(02)00509-7 | ||
CHEMBL2112368 | 78249 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 407 | 4 | 1 | 4 | 5.0 | COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN[C@H]2c2ccccc2)C1 | 10.1016/s0960-894x(02)00509-7 | ||
22885695 | 138594 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 564 | 10 | 1 | 4 | 6.0 | COCCNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL378689 | 138594 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 564 | 10 | 1 | 4 | 6.0 | COCCNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
46881600 | 7027 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 493 | 5 | 1 | 3 | 5.3 | CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1085196 | 7027 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 493 | 5 | 1 | 3 | 5.3 | CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO | 10.1016/j.bmcl.2010.01.065 | ||
44444689 | 93790 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 517 | 5 | 1 | 4 | 5.6 | C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL249938 | 93790 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 517 | 5 | 1 | 4 | 5.6 | C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
44444671 | 154218 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 575 | 4 | 0 | 3 | 5.7 | CC(=O)N1CCN(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL400060 | 154218 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 575 | 4 | 0 | 3 | 5.7 | CC(=O)N1CCN(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 | 10.1016/j.bmcl.2007.06.085 | ||
57402688 | 71262 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.3 | COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917843 | 71262 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.3 | COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963298 | 71262 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.3 | COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
52941489 | 17549 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 516 | 4 | 1 | 3 | 5.2 | C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1258623 | 17549 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 516 | 4 | 1 | 3 | 5.2 | C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
10768417 | 165050 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 525 | 7 | 0 | 4 | 5.7 | O=C(Cn1ccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL424291 | 165050 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 525 | 7 | 0 | 4 | 5.7 | O=C(Cn1ccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL1651026 | 207083 | 19 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O | 10.1016/j.ejmech.2013.01.044 | ||||
58993533 | 121584 | 0 | None | - | 0 | Mongolian jird | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 486 | 6 | 1 | 3 | 6.4 | N#Cc1c(F)cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596485 | 121584 | 0 | None | - | 0 | Mongolian jird | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 486 | 6 | 1 | 3 | 6.4 | N#Cc1c(F)cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F | 10.1016/j.bmcl.2015.04.098 | ||
19797422 | 96215 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 523 | 6 | 0 | 2 | 6.4 | Cc1cc(I)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL263795 | 96215 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 523 | 6 | 0 | 2 | 6.4 | Cc1cc(I)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(96)00148-5 | ||
10346229 | 82609 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 509 | 7 | 0 | 4 | 6.6 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)n(C)c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21813 | 82609 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 509 | 7 | 0 | 4 | 6.6 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)n(C)c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
21955317 | 103038 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 632 | 7 | 2 | 3 | 7.9 | CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(O)(Cc3ccccc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL3085130 | 103038 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 632 | 7 | 2 | 3 | 7.9 | CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(O)(Cc3ccccc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
44412374 | 77441 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 491 | 4 | 0 | 2 | 6.7 | C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(=O)N1C | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL209240 | 77441 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 491 | 4 | 0 | 2 | 6.7 | C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(=O)N1C | 10.1016/j.bmcl.2006.02.080 | ||
11678857 | 138777 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 608 | 4 | 0 | 3 | 7.6 | CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O | 10.1016/j.bmcl.2005.11.111 | ||
CHEMBL379224 | 138777 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 608 | 4 | 0 | 3 | 7.6 | CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O | 10.1016/j.bmcl.2005.11.111 | ||
44456865 | 97454 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 477 | 4 | 0 | 3 | 5.9 | C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL272469 | 97454 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 477 | 4 | 0 | 3 | 5.9 | C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
14986135 | 162849 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm058225d | ||
CHEMBL419500 | 162849 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm058225d | ||
44334275 | 5003 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 485 | 7 | 0 | 3 | 6.3 | CC(C)CCN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL105420 | 5003 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 485 | 7 | 0 | 3 | 6.3 | CC(C)CCN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00616-3 | ||
9871754 | 5337 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
CHEMBL107172 | 5337 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
10415870 | 103035 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 582 | 5 | 1 | 3 | 7.3 | CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL3085127 | 103035 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 582 | 5 | 1 | 3 | 7.3 | CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
10483816 | 190604 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL51893 | 190604 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00250-0 | ||
10483816 | 79220 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2115007 | 79220 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
10415870 | 140078 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 582 | 5 | 1 | 3 | 7.3 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.111 | ||
CHEMBL381390 | 140078 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 582 | 5 | 1 | 3 | 7.3 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.111 | ||
53379508 | 66128 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 469 | 7 | 0 | 4 | 5.8 | COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817891 | 66128 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 469 | 7 | 0 | 4 | 5.8 | COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852123 | 66128 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 469 | 7 | 0 | 4 | 5.8 | COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
22885696 | 138399 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 532 | 7 | 2 | 3 | 6.1 | C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL378416 | 138399 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 532 | 7 | 2 | 3 | 6.1 | C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
44444654 | 93623 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 534 | 5 | 1 | 4 | 5.0 | C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2COC(=O)N2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL248943 | 93623 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 534 | 5 | 1 | 4 | 5.0 | C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2COC(=O)N2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
15516313 | 178140 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 434 | 5 | 2 | 4 | 4.6 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@@](C)(C(F)(F)F)OCC2 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL468350 | 178140 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 434 | 5 | 2 | 4 | 4.6 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@@](C)(C(F)(F)F)OCC2 | 10.1016/j.bmc.2008.06.047 | ||
44593636 | 181038 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 432 | 5 | 2 | 3 | 5.4 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL477365 | 181038 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 432 | 5 | 2 | 3 | 5.4 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 | 10.1016/j.bmc.2008.06.047 | ||
9871754 | 5337 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm00016a014 | ||
CHEMBL107172 | 5337 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm00016a014 | ||
10698096 | 55583 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL162337 | 55583 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
9871754 | 5337 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm990220r | ||
CHEMBL107172 | 5337 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm990220r | ||
44334149 | 4531 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 497 | 5 | 0 | 3 | 6.6 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(C3CCCCC3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL102730 | 4531 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 497 | 5 | 0 | 3 | 6.6 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(C3CCCCC3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
10393962 | 103040 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 610 | 5 | 1 | 3 | 8.2 | CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CC2)CCC(C)(C)O3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL3085132 | 103040 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 610 | 5 | 1 | 3 | 8.2 | CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CC2)CCC(C)(C)O3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
22293475 | 186545 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 620 | 6 | 1 | 2 | 8.8 | CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL49176 | 186545 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 620 | 6 | 1 | 2 | 8.8 | CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
18782542 | 110977 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 405 | 4 | 1 | 4 | 4.9 | COc1ccc(OC(F)(F)F)cc1C1=CC2(CCCNC2c2ccccc2)OC1 | 10.1016/s0960-894x(02)00509-7 | ||
CHEMBL327606 | 110977 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 405 | 4 | 1 | 4 | 4.9 | COc1ccc(OC(F)(F)F)cc1C1=CC2(CCCNC2c2ccccc2)OC1 | 10.1016/s0960-894x(02)00509-7 | ||
11146618 | 78398 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 631 | 10 | 1 | 6 | 7.3 | CC(C)N(Cc1[nH]nnc1CN1CCO[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1)C(C)C | 10.1021/jm0109558 | ||
CHEMBL2112742 | 78398 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 631 | 10 | 1 | 6 | 7.3 | CC(C)N(Cc1[nH]nnc1CN1CCO[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1)C(C)C | 10.1021/jm0109558 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
44346234 | 14478 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 322 | 4 | 0 | 3 | 3.7 | COc1ccccc1CN1CCN2CCC[C@H]1[C@@H]2c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL120523 | 14478 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 322 | 4 | 0 | 3 | 3.7 | COc1ccccc1CN1CCN2CCC[C@H]1[C@@H]2c1ccccc1 | 10.1021/jm9700171 | ||
10415534 | 165653 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 567 | 10 | 3 | 3 | 6.2 | O=C(CCC1CCNCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL426577 | 165653 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 567 | 10 | 3 | 3 | 6.2 | O=C(CCC1CCNCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
2098 | 3638 | 31 | None | -1 | 6 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80229-8 | ||||
36511 | 3638 | 31 | None | -1 | 6 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80229-8 | ||||
3805 | 3638 | 31 | None | -1 | 6 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80229-8 | ||||
3835 | 3638 | 31 | None | -1 | 6 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80229-8 | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 6 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80229-8 | ||||
22885704 | 81113 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 576 | 7 | 0 | 4 | 6.0 | C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCOCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL216018 | 81113 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 576 | 7 | 0 | 4 | 6.0 | C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCOCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
24752568 | 8824 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1097693 | 8824 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
24752568 | 8824 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1097693 | 8824 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
44444659 | 93738 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 492 | 4 | 0 | 2 | 6.1 | C[C@@H](O[C@@H]1CN(C(=O)N(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL249568 | 93738 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 492 | 4 | 0 | 2 | 6.1 | C[C@@H](O[C@@H]1CN(C(=O)N(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
9855000 | 20421 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 559 | 3 | 0 | 4 | 6.8 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
CHEMBL130834 | 20421 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 559 | 3 | 0 | 4 | 6.8 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
18669080 | 4939 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 519 | 6 | 0 | 3 | 6.0 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL105047 | 4939 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 519 | 6 | 0 | 3 | 6.0 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
10210026 | 100890 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 569 | 6 | 1 | 3 | 6.8 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL296979 | 100890 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 569 | 6 | 1 | 3 | 6.8 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
58993465 | 121593 | 0 | None | - | 0 | Mongolian jird | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 492 | 7 | 0 | 3 | 7.2 | CC(C)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596494 | 121593 | 0 | None | - | 0 | Mongolian jird | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 492 | 7 | 0 | 3 | 7.2 | CC(C)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2015.04.098 | ||
22885702 | 80096 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 534 | 7 | 0 | 3 | 6.3 | C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL214761 | 80096 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 534 | 7 | 0 | 3 | 6.3 | C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
46884434 | 7843 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 593 | 6 | 1 | 3 | 7.3 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090288 | 7843 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 593 | 6 | 1 | 3 | 7.3 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44346438 | 114252 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 564 | 8 | 0 | 3 | 7.1 | CN(Cc1ccccc1)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL333882 | 114252 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 564 | 8 | 0 | 3 | 7.1 | CN(Cc1ccccc1)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1021/jm9700171 | ||
10098987 | 59666 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 547 | 9 | 2 | 3 | 6.1 | O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL173396 | 59666 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 547 | 9 | 2 | 3 | 6.1 | O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00035a006 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00035a006 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm950654w | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm950654w | ||
44410317 | 76797 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 543 | 5 | 1 | 6 | 5.6 | C[C@@H](OC1CCC2NC1(c1ccccc1)CC2(F)c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
CHEMBL207794 | 76797 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 543 | 5 | 1 | 6 | 5.6 | C[C@@H](OC1CCC2NC1(c1ccccc1)CC2(F)c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
44415921 | 141215 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 492 | 7 | 2 | 3 | 5.3 | C[C@@H](O[C@H]1CC[C@@H](NCC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL385925 | 141215 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 492 | 7 | 2 | 3 | 5.3 | C[C@@H](O[C@H]1CC[C@@H](NCC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
24889458 | 8345 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 583 | 6 | 0 | 5 | 6.7 | CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1093594 | 8345 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 583 | 6 | 0 | 5 | 6.7 | CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 | 10.1016/j.bmcl.2010.01.120 | ||
46947062 | 17278 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257706 | 17278 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
46947062 | 17278 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257706 | 17278 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
9821217 | 107244 | 17 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL319118 | 107244 | 17 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL3215877 | 107244 | 17 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 4.2 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
44593633 | 181860 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 404 | 5 | 2 | 3 | 4.9 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL478620 | 181860 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 404 | 5 | 2 | 3 | 4.9 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 | 10.1016/j.bmc.2008.06.047 | ||
44577989 | 188840 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 4.9 | COc1ccc(C(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL513351 | 188840 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 4.9 | COc1ccc(C(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
9984665 | 5270 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 536 | 4 | 0 | 3 | 6.7 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL106864 | 5270 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 536 | 4 | 0 | 3 | 6.7 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
104943 | 55099 | 34 | None | - | 3 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
CHEMBL16192 | 55099 | 34 | None | - | 3 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
2098 | 3638 | 31 | None | -1 | 6 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm070577s | ||||
36511 | 3638 | 31 | None | -1 | 6 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm070577s | ||||
3805 | 3638 | 31 | None | -1 | 6 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm070577s | ||||
3835 | 3638 | 31 | None | -1 | 6 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm070577s | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 6 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm070577s | ||||
44412493 | 77541 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 477 | 4 | 1 | 2 | 6.4 | C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CC(=O)N1 | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL209407 | 77541 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 477 | 4 | 1 | 2 | 6.4 | C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CC(=O)N1 | 10.1016/j.bmcl.2006.02.080 | ||
44415909 | 79476 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 545 | 7 | 2 | 4 | 6.8 | C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2c[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL212349 | 79476 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 545 | 7 | 2 | 4 | 6.8 | C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2c[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
49863732 | 15158 | 0 | None | 24 | 4 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 1266 | 18 | 10 | 12 | 6.1 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm100157m | ||
CHEMBL1214025 | 15158 | 0 | None | 24 | 4 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 1266 | 18 | 10 | 12 | 6.1 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm100157m | ||
135430679 | 45785 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 408 | 8 | 2 | 5 | 4.5 | Cc1cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)cc(C(C)(C)C)c1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL153310 | 45785 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 408 | 8 | 2 | 5 | 4.5 | Cc1cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)cc(C(C)(C)C)c1 | 10.1016/s0960-894x(97)10163-9 | ||
44294660 | 103041 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 610 | 6 | 1 | 4 | 7.1 | CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCOC3=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL3085133 | 103041 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 610 | 6 | 1 | 4 | 7.1 | CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCOC3=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
53379509 | 66123 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 427 | 7 | 0 | 3 | 6.0 | COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817892 | 66123 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 427 | 7 | 0 | 3 | 6.0 | COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852099 | 66123 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 427 | 7 | 0 | 3 | 6.0 | COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
44433789 | 145601 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 583 | 5 | 0 | 3 | 5.2 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL391963 | 145601 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 583 | 5 | 0 | 3 | 5.2 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
24750888 | 8366 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 504 | 4 | 1 | 3 | 5.4 | C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1093751 | 8366 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 504 | 4 | 1 | 3 | 5.4 | C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
135430775 | 45089 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 474 | 8 | 2 | 5 | 4.9 | CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL152685 | 45089 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 474 | 8 | 2 | 5 | 4.9 | CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
44412235 | 139645 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 486 | 4 | 0 | 3 | 6.9 | C[C@@H](O[C@H]1CCn2ccnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL380388 | 139645 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 486 | 4 | 0 | 3 | 6.9 | C[C@@H](O[C@H]1CCn2ccnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
44415808 | 81049 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 560 | 7 | 0 | 3 | 6.8 | C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL215975 | 81049 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 560 | 7 | 0 | 3 | 6.8 | C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
11756257 | 167220 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 515 | 12 | 3 | 5 | 3.8 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL43044 | 167220 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 515 | 12 | 3 | 5 | 3.8 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
18669059 | 98315 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 521 | 6 | 1 | 3 | 6.5 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL278149 | 98315 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 521 | 6 | 1 | 3 | 6.5 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
44412373 | 138570 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 491 | 4 | 0 | 2 | 6.6 | C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CN(C)C1=O | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL378663 | 138570 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 491 | 4 | 0 | 2 | 6.6 | C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CN(C)C1=O | 10.1016/j.bmcl.2006.02.080 | ||
21955285 | 188407 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 636 | 7 | 2 | 3 | 7.8 | O=C(N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL50867 | 188407 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 636 | 7 | 2 | 3 | 7.8 | O=C(N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00006a012 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00006a012 | ||
24785978 | 121582 | 0 | None | - | 0 | Mongolian jird | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 6.1 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596483 | 121582 | 0 | None | - | 0 | Mongolian jird | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 6.1 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
9329 | 3684 | 3 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 | 10.1016/j.bmc.2011.07.014 | ||
9894349 | 3684 | 3 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL339486 | 3684 | 3 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 | 10.1016/j.bmc.2011.07.014 | ||
9329 | 3684 | 3 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 | 10.1021/jm990220r | ||
9894349 | 3684 | 3 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 | 10.1021/jm990220r | ||
CHEMBL339486 | 3684 | 3 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 | 10.1021/jm990220r | ||
10392469 | 193186 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 538 | 10 | 3 | 5 | 5.6 | C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm010825z | ||
CHEMBL539928 | 193186 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 538 | 10 | 3 | 5 | 5.6 | C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm010825z | ||
44177669 | 60932 | 0 | None | 2 | 4 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 1233 | 27 | 9 | 10 | 6.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766205 | 60932 | 0 | None | 2 | 4 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 1233 | 27 | 9 | 10 | 6.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
10325507 | 60121 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 561 | 10 | 2 | 3 | 6.5 | O=C(CCc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL175224 | 60121 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 561 | 10 | 2 | 3 | 6.5 | O=C(CCc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
44444674 | 93889 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 639 | 4 | 0 | 5 | 6.7 | C[C@@H](O[C@@H]1CN(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL250596 | 93889 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 639 | 4 | 0 | 5 | 6.7 | C[C@@H](O[C@@H]1CN(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
44408291 | 140349 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 677 | 5 | 0 | 3 | 8.1 | CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4Cl)C(=O)C3)CC2)C1=O | 10.1016/j.bmcl.2005.11.111 | ||
CHEMBL381984 | 140349 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 677 | 5 | 0 | 3 | 8.1 | CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4Cl)C(=O)C3)CC2)C1=O | 10.1016/j.bmcl.2005.11.111 | ||
44408177 | 140444 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 624 | 5 | 0 | 4 | 7.1 | COC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O | 10.1016/j.bmcl.2005.11.111 | ||
CHEMBL382331 | 140444 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 624 | 5 | 0 | 4 | 7.1 | COC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O | 10.1016/j.bmcl.2005.11.111 | ||
44408290 | 140718 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 643 | 5 | 0 | 3 | 7.4 | CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4)C(=O)C3)CC2)C1=O | 10.1016/j.bmcl.2005.11.111 | ||
CHEMBL383048 | 140718 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 643 | 5 | 0 | 3 | 7.4 | CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4)C(=O)C3)CC2)C1=O | 10.1016/j.bmcl.2005.11.111 | ||
10007758 | 178403 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 551 | 12 | 2 | 6 | 4.5 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL47070 | 178403 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 551 | 12 | 2 | 6 | 4.5 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
46227363 | 197984 | 0 | None | 28 | 4 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL592969 | 197984 | 0 | None | 28 | 4 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
44412453 | 161140 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 491 | 4 | 0 | 2 | 6.7 | C[C@@H](O[C@H]1C[C@@H](C)N(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL413279 | 161140 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 491 | 4 | 0 | 2 | 6.7 | C[C@@H](O[C@H]1C[C@@H](C)N(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
21955222 | 101313 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 6 | 1 | 2 | 9.0 | CC(C)(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL300014 | 101313 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 6 | 1 | 2 | 9.0 | CC(C)(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
10392469 | 193186 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 538 | 10 | 3 | 5 | 5.6 | C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm501535r | ||
CHEMBL539928 | 193186 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 538 | 10 | 3 | 5 | 5.6 | C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm501535r | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00006a012 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00006a012 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00006a012 | ||
10098987 | 59666 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 547 | 9 | 2 | 3 | 6.1 | O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL173396 | 59666 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 547 | 9 | 2 | 3 | 6.1 | O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00006a012 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00006a012 | ||
10720240 | 34870 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 502 | 7 | 0 | 3 | 5.4 | CN(C)CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL143375 | 34870 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 502 | 7 | 0 | 3 | 5.4 | CN(C)CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80534-5 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80534-5 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm9506534 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm9506534 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm9506534 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm950654w | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm950654w | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm950654w | ||
105083 | 25247 | 3 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 | 10.1021/jm980299k | ||
CHEMBL135022 | 25247 | 3 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 | 10.1021/jm980299k | ||
44410278 | 140333 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 525 | 5 | 1 | 6 | 5.5 | C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
CHEMBL381965 | 140333 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 525 | 5 | 1 | 6 | 5.5 | C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
44408176 | 73974 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 594 | 4 | 0 | 3 | 7.4 | O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 | 10.1016/j.bmcl.2005.11.111 | ||
CHEMBL202439 | 73974 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 594 | 4 | 0 | 3 | 7.4 | O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 | 10.1016/j.bmcl.2005.11.111 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80349-2 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80349-2 | ||
44593634 | 182207 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 418 | 5 | 2 | 3 | 5.3 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CCC2 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL479049 | 182207 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 418 | 5 | 2 | 3 | 5.3 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CCC2 | 10.1016/j.bmc.2008.06.047 | ||
10099939 | 4918 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 589 | 7 | 2 | 3 | 5.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(01)00631-x | ||
CHEMBL104954 | 4918 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 589 | 7 | 2 | 3 | 5.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(01)00631-x | ||
9830304 | 106863 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 608 | 7 | 2 | 4 | 5.2 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 | 10.1016/s0960-894x(01)00631-x | ||
CHEMBL317632 | 106863 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 608 | 7 | 2 | 4 | 5.2 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 | 10.1016/s0960-894x(01)00631-x | ||
10099939 | 4918 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 589 | 7 | 2 | 3 | 5.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(00)00260-2 | ||
CHEMBL104954 | 4918 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 589 | 7 | 2 | 3 | 5.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(00)00260-2 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80747-2 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00080-D | ||
10814682 | 205980 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 6.4 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL95626 | 205980 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 6.4 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
44433798 | 145153 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 643 | 5 | 0 | 3 | 6.4 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL391615 | 145153 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 643 | 5 | 0 | 3 | 6.4 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
46884468 | 7910 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 578 | 5 | 0 | 3 | 7.5 | Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090650 | 7910 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 578 | 5 | 0 | 3 | 7.5 | Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 | 10.1016/j.bmcl.2010.01.120 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
44415896 | 138385 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 507 | 8 | 0 | 3 | 6.8 | COCCN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL378331 | 138385 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 507 | 8 | 0 | 3 | 6.8 | COCCN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
44299271 | 194374 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 510 | 10 | 2 | 3 | 5.5 | NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL56038 | 194374 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 510 | 10 | 2 | 3 | 5.5 | NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
42639649 | 170178 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 553 | 5 | 0 | 4 | 7.4 | C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
CHEMBL445239 | 170178 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 553 | 5 | 0 | 4 | 7.4 | C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
44334107 | 4339 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 532 | 6 | 0 | 3 | 7.2 | CC(=O)C1(c2ccccc2)CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL101421 | 4339 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 532 | 6 | 0 | 3 | 7.2 | CC(=O)C1(c2ccccc2)CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00616-3 | ||
44299271 | 194374 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 510 | 10 | 2 | 3 | 5.5 | NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL56038 | 194374 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 510 | 10 | 2 | 3 | 5.5 | NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
10814682 | 205980 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 6.4 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
CHEMBL95626 | 205980 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 6.4 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
44412159 | 140390 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 477 | 4 | 0 | 2 | 6.3 | C[C@@H](O[C@H]1CCN(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL382255 | 140390 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 477 | 4 | 0 | 2 | 6.3 | C[C@@H](O[C@H]1CCN(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
46884430 | 8236 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 487 | 4 | 0 | 2 | 6.3 | C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1092755 | 8236 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 487 | 4 | 0 | 2 | 6.3 | C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
22901329 | 98622 | 1 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 510 | 10 | 2 | 3 | 5.5 | NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1021/jm0311487 | ||
CHEMBL28055 | 98622 | 1 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 510 | 10 | 2 | 3 | 5.5 | NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1021/jm0311487 | ||
9805809 | 102613 | 6 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 495 | 8 | 3 | 4 | 6.0 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL307488 | 102613 | 6 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 495 | 8 | 3 | 4 | 6.0 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm00022a010 | ||
44334127 | 4566 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 522 | 6 | 0 | 2 | 7.7 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL102937 | 4566 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 522 | 6 | 0 | 2 | 7.7 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
44415554 | 138520 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 515 | 7 | 2 | 3 | 6.8 | C[C@@H](O[C@H]1CC[C@@H](NCc2ncc[nH]2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL378609 | 138520 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 515 | 7 | 2 | 3 | 6.8 | C[C@@H](O[C@H]1CC[C@@H](NCc2ncc[nH]2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
136094860 | 204391 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 454 | 5 | 2 | 7 | 3.2 | COc1ccccc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL85792 | 204391 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 454 | 5 | 2 | 7 | 3.2 | COc1ccccc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
44433796 | 89761 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 550 | 5 | 0 | 4 | 5.3 | Cc1cnc(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL238220 | 89761 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 550 | 5 | 0 | 4 | 5.3 | Cc1cnc(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 | 10.1016/j.bmcl.2007.08.028 | ||
44444677 | 154444 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 545 | 6 | 2 | 4 | 5.4 | C[C@@H](O[C@@H]1CN(C(=O)NCc2cn[nH]n2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
CHEMBL401281 | 154444 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 545 | 6 | 2 | 4 | 5.4 | C[C@@H](O[C@@H]1CN(C(=O)NCc2cn[nH]n2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.06.085 | ||
44312057 | 202747 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 690 | 7 | 2 | 5 | 7.7 | CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL72234 | 202747 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 690 | 7 | 2 | 5 | 7.7 | CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
24785978 | 121582 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 6.1 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596483 | 121582 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 6.1 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
10392925 | 14312 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 555 | 12 | 2 | 3 | 6.2 | CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL120081 | 14312 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 555 | 12 | 2 | 3 | 6.2 | CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
10076669 | 59902 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 567 | 10 | 2 | 3 | 6.3 | O=C(CCN1CCCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL174016 | 59902 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 567 | 10 | 2 | 3 | 6.3 | O=C(CCN1CCCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
11800025 | 120767 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 516 | 8 | 0 | 3 | 5.8 | CN(C)CCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL357887 | 120767 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 516 | 8 | 0 | 3 | 5.8 | CN(C)CCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
18669082 | 165163 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 487 | 6 | 1 | 3 | 6.1 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL424586 | 165163 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 487 | 6 | 1 | 3 | 6.1 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
18669082 | 165163 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 487 | 6 | 1 | 3 | 6.1 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL424586 | 165163 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 487 | 6 | 1 | 3 | 6.1 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL2115376 | 207523 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O | 10.1021/jm00037a009 | ||||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
44410191 | 140161 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 583 | 6 | 1 | 4 | 7.1 | C[C@@H](OC1CCC2NC1(c1ccccc1)CC2S(=O)(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
CHEMBL381555 | 140161 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 583 | 6 | 1 | 4 | 7.1 | C[C@@H](OC1CCC2NC1(c1ccccc1)CC2S(=O)(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
44415947 | 79893 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 526 | 7 | 1 | 3 | 7.4 | C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL214118 | 79893 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 526 | 7 | 1 | 3 | 7.4 | C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
24750734 | 7931 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1090742 | 7931 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
24750734 | 7931 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1090742 | 7931 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm0311487 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm0311487 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm0311487 | ||
44305288 | 201190 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 6.8 | CN(O)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL62649 | 201190 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 6.8 | CN(O)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 | 10.1016/s0960-894x(02)00382-7 | ||
10392925 | 14312 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 555 | 12 | 2 | 3 | 6.2 | CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL120081 | 14312 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 555 | 12 | 2 | 3 | 6.2 | CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
18686789 | 92542 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 308 | 4 | 0 | 3 | 3.7 | COc1ccccc1CN1CN2CCCC1C2c1ccccc1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL2441369 | 92542 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 308 | 4 | 0 | 3 | 3.7 | COc1ccccc1CN1CN2CCCC1C2c1ccccc1 | 10.1016/j.bmc.2013.09.001 | ||
136094778 | 138731 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 515 | 8 | 4 | 6 | 3.8 | O=c1nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH][nH]1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL379010 | 138731 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 515 | 8 | 4 | 6 | 3.8 | O=c1nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH][nH]1 | 10.1016/j.bmcl.2005.11.026 | ||
10357939 | 117576 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 308 | 4 | 0 | 3 | 3.7 | COc1ccccc1CN1CN2CCC[C@H]1[C@@H]2c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL340559 | 117576 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 308 | 4 | 0 | 3 | 3.7 | COc1ccccc1CN1CN2CCC[C@H]1[C@@H]2c1ccccc1 | 10.1021/jm9700171 | ||
44294291 | 100720 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 634 | 6 | 1 | 2 | 9.0 | CC(C)(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL295685 | 100720 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 634 | 6 | 1 | 2 | 9.0 | CC(C)(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
44408158 | 139649 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 617 | 6 | 1 | 3 | 7.1 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(c3ccccc3)C(=O)C2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.111 | ||
CHEMBL380408 | 139649 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 617 | 6 | 1 | 3 | 7.1 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(c3ccccc3)C(=O)C2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.111 | ||
56662745 | 64312 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 499 | 6 | 0 | 3 | 6.0 | COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817889 | 64312 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 499 | 6 | 0 | 3 | 6.0 | COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817897 | 64312 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 499 | 6 | 0 | 3 | 6.0 | COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
10258336 | 100812 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 620 | 6 | 1 | 2 | 8.8 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL296397 | 100812 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 620 | 6 | 1 | 2 | 8.8 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
44307416 | 201319 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 474 | 6 | 1 | 3 | 5.2 | CNC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL63240 | 201319 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 474 | 6 | 1 | 3 | 5.2 | CNC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
10258336 | 100812 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 620 | 6 | 1 | 2 | 8.8 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL296397 | 100812 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 620 | 6 | 1 | 2 | 8.8 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
44456703 | 157809 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 533 | 5 | 1 | 4 | 6.6 | C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL408960 | 157809 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 533 | 5 | 1 | 4 | 6.6 | C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2007.10.010 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2007.10.010 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmcl.2007.10.010 | ||
2098 | 3638 | 31 | None | -1 | 6 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00037a009 | ||||
36511 | 3638 | 31 | None | -1 | 6 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00037a009 | ||||
3805 | 3638 | 31 | None | -1 | 6 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00037a009 | ||||
3835 | 3638 | 31 | None | -1 | 6 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00037a009 | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 6 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00037a009 | ||||
44412225 | 139179 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 463 | 4 | 1 | 2 | 6.0 | C[C@@H](O[C@H]1CCNC(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
CHEMBL379816 | 139179 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 463 | 4 | 1 | 2 | 6.0 | C[C@@H](O[C@H]1CCNC(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.02.080 | ||
44407431 | 72882 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 500 | 8 | 3 | 7 | 3.9 | FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3NC2(c2ccccc2)CC3c2nnn[nH]2)c1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL201192 | 72882 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 500 | 8 | 3 | 7 | 3.9 | FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3NC2(c2ccccc2)CC3c2nnn[nH]2)c1 | 10.1016/j.bmcl.2005.11.026 | ||
10076383 | 100756 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 555 | 11 | 2 | 5 | 5.2 | CC(=O)N(Cc1ccccc1Cl)C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1 | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL296013 | 100756 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 555 | 11 | 2 | 5 | 5.2 | CC(=O)N(Cc1ccccc1Cl)C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1 | 10.1016/s0960-894x(01)00250-5 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2013.09.001 | ||
44408313 | 74153 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 610 | 4 | 1 | 4 | 6.5 | O=C1N([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)CCC1(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.111 | ||
CHEMBL202884 | 74153 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 610 | 4 | 1 | 4 | 6.5 | O=C1N([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)CCC1(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.111 | ||
52941550 | 17622 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1258852 | 17622 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
44433784 | 89759 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 540 | 5 | 0 | 2 | 6.5 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCCCC2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL238210 | 89759 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 540 | 5 | 0 | 2 | 6.5 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCCCC2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
44416136 | 79397 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 578 | 10 | 0 | 4 | 6.3 | COCCN(C)C(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL212025 | 79397 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 578 | 10 | 0 | 4 | 6.3 | COCCN(C)C(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.044 | ||
9855000 | 20421 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 559 | 3 | 0 | 4 | 6.8 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
CHEMBL130834 | 20421 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 559 | 3 | 0 | 4 | 6.8 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
10347274 | 128151 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 541 | 11 | 2 | 3 | 5.8 | CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL366818 | 128151 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 541 | 11 | 2 | 3 | 5.8 | CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80280-8 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80280-8 | ||
21955298 | 79219 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2115006 | 79219 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL396426 | 210749 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O | 10.1021/jm070577s | ||||
44415967 | 138172 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 526 | 7 | 1 | 3 | 7.4 | C[C@@H](O[C@H]1CC[C@@H](NCc2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL377917 | 138172 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 526 | 7 | 1 | 3 | 7.4 | C[C@@H](O[C@H]1CC[C@@H](NCc2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
46947062 | 17278 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257706 | 17278 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
10502796 | 32098 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 431 | 5 | 0 | 2 | 5.9 | CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL141034 | 32098 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 431 | 5 | 0 | 2 | 5.9 | CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmc.2013.02.010 | ||
44578024 | 178117 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 396 | 6 | 2 | 3 | 4.9 | COc1ccc(C(F)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL468163 | 178117 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 396 | 6 | 2 | 3 | 4.9 | COc1ccc(C(F)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
10372941 | 119003 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 757 | 14 | 1 | 5 | 8.2 | COc1ccccc1CN(C)CCNC(=O)[C@@H]1C[C@@H](C(=O)N(Cc2ccccc2)Cc2ccccc2)CCN1C(=O)N(c1ccccc1)c1cccc(Cl)c1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL345520 | 119003 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 757 | 14 | 1 | 5 | 8.2 | COc1ccccc1CN(C)CCNC(=O)[C@@H]1C[C@@H](C(=O)N(Cc2ccccc2)Cc2ccccc2)CCN1C(=O)N(c1ccccc1)c1cccc(Cl)c1 | 10.1016/0960-894X(95)00080-D | ||
10885893 | 102439 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 525 | 10 | 3 | 5 | 5.6 | COC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 | 10.1021/jm010825z | ||
CHEMBL306089 | 102439 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 525 | 10 | 3 | 5 | 5.6 | COC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 | 10.1021/jm010825z | ||
10553959 | 187287 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(00)80046-3 | ||
CHEMBL49638 | 187287 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(00)80046-3 | ||
44305221 | 100559 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 551 | 8 | 3 | 6 | 4.7 | COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL294545 | 100559 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 551 | 8 | 3 | 6 | 4.7 | COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/s0960-894x(02)00382-7 | ||
10553959 | 187287 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL49638 | 187287 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
44313273 | 203261 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 481 | 8 | 3 | 4 | 5.6 | C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm010825z | ||
CHEMBL76501 | 203261 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 481 | 8 | 3 | 4 | 5.6 | C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm010825z | ||
44433793 | 147852 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 536 | 5 | 0 | 4 | 5.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cnccn2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL393746 | 147852 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 536 | 5 | 0 | 4 | 5.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cnccn2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL396426 | 210749 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O | 10.1021/jm070577s | ||||
22293505 | 188938 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 623 | 8 | 1 | 3 | 8.7 | OCC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL51417 | 188938 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 623 | 8 | 1 | 3 | 8.7 | OCC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
25028925 | 90934 | 2 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 570 | 5 | 1 | 5 | 5.5 | Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 | 10.1021/jm400751p | ||
CHEMBL2402572 | 90934 | 2 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 570 | 5 | 1 | 5 | 5.5 | Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 | 10.1021/jm400751p | ||
44358731 | 30126 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 609 | 7 | 1 | 3 | 7.4 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL139167 | 30126 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 609 | 7 | 1 | 3 | 7.4 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
10077113 | 121029 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 589 | 7 | 2 | 3 | 5.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(00)00260-2 | ||
CHEMBL35857 | 121029 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 589 | 7 | 2 | 3 | 5.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(00)00260-2 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
22293475 | 186545 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 620 | 6 | 1 | 2 | 8.8 | CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL49176 | 186545 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 620 | 6 | 1 | 2 | 8.8 | CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
44415444 | 79812 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 418 | 5 | 1 | 2 | 5.8 | OC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL213726 | 79812 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 418 | 5 | 1 | 2 | 5.8 | OC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
52949827 | 17160 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 531 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257357 | 17160 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 531 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
24750734 | 7931 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1090742 | 7931 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL229280 | 207713 | 0 | None | 23 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC[S+](C)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
44333607 | 4906 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 469 | 6 | 0 | 3 | 5.6 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CC3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL104883 | 4906 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 469 | 6 | 0 | 3 | 5.6 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CC3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
10142159 | 81132 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 507 | 6 | 1 | 4 | 5.8 | O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL21607 | 81132 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 507 | 6 | 1 | 4 | 5.8 | O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
44274180 | 162640 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 552 | 7 | 1 | 4 | 7.3 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccco3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL418186 | 162640 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 552 | 7 | 1 | 4 | 7.3 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccco3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
44433787 | 88104 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 555 | 5 | 1 | 2 | 6.4 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)NC2CCCCC2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL235219 | 88104 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 555 | 5 | 1 | 2 | 6.4 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)NC2CCCCC2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
11800024 | 206516 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 516 | 6 | 2 | 5 | 6.1 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL98811 | 206516 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 516 | 6 | 2 | 5 | 6.1 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
136180340 | 119104 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 488 | 9 | 2 | 5 | 5.3 | CCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL346447 | 119104 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 488 | 9 | 2 | 5 | 5.3 | CCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
10053205 | 116085 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 547 | 4 | 0 | 4 | 6.8 | Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
CHEMBL336589 | 116085 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 547 | 4 | 0 | 4 | 6.8 | Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
11800024 | 206516 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 516 | 6 | 2 | 5 | 6.1 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
CHEMBL98811 | 206516 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 516 | 6 | 2 | 5 | 6.1 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
44408123 | 140057 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 608 | 4 | 0 | 3 | 7.8 | O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 | 10.1016/j.bmcl.2005.11.111 | ||
CHEMBL381362 | 140057 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 608 | 4 | 0 | 3 | 7.8 | O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 | 10.1016/j.bmcl.2005.11.111 | ||
46881682 | 8013 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1091469 | 8013 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
10578351 | 119723 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 539 | 12 | 2 | 5 | 3.7 | COc1ccccc1CN(C=O)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL352176 | 119723 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 539 | 12 | 2 | 5 | 3.7 | COc1ccccc1CN(C=O)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
71449072 | 78168 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 645 | 5 | 2 | 3 | 7.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL2112212 | 78168 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 645 | 5 | 2 | 3 | 7.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00382-7 | ||
56668401 | 66110 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 505 | 7 | 0 | 4 | 6.1 | COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817890 | 66110 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 505 | 7 | 0 | 4 | 6.1 | COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852009 | 66110 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 505 | 7 | 0 | 4 | 6.1 | COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
44415404 | 79631 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 514 | 7 | 1 | 3 | 5.8 | CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL212931 | 79631 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 514 | 7 | 1 | 3 | 5.8 | CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
10721713 | 119532 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 567 | 12 | 2 | 5 | 4.5 | CCC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL350381 | 119532 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 567 | 12 | 2 | 5 | 4.5 | CCC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
18709649 | 164454 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 515 | 12 | 3 | 5 | 3.8 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL42259 | 164454 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 515 | 12 | 3 | 5 | 3.8 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
44415550 | 165583 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.8 | CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL426145 | 165583 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.8 | CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
46881820 | 7480 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 542 | 5 | 0 | 5 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1087695 | 7480 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 542 | 5 | 0 | 5 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
44433792 | 147850 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 536 | 5 | 0 | 4 | 5.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ncccn2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL393745 | 147850 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 536 | 5 | 0 | 4 | 5.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ncccn2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
22901329 | 98622 | 1 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 510 | 10 | 2 | 3 | 5.5 | NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL28055 | 98622 | 1 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 510 | 10 | 2 | 3 | 5.5 | NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
22901329 | 98622 | 1 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 510 | 10 | 2 | 3 | 5.5 | NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL28055 | 98622 | 1 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 510 | 10 | 2 | 3 | 5.5 | NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
44294689 | 101142 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 542 | 5 | 2 | 3 | 6.2 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL298858 | 101142 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 542 | 5 | 2 | 3 | 6.2 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
11016806 | 203249 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 523 | 10 | 3 | 4 | 6.8 | CCC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 | 10.1021/jm010825z | ||
CHEMBL76455 | 203249 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 523 | 10 | 3 | 4 | 6.8 | CCC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 | 10.1021/jm010825z | ||
9829083 | 119634 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL351274 | 119634 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
10816374 | 18707 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 545 | 3 | 0 | 4 | 6.5 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
CHEMBL128384 | 18707 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 545 | 3 | 0 | 4 | 6.5 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
132846 | 96998 | 21 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL1256740 | 96998 | 21 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL27006 | 96998 | 21 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00009-I | ||
132846 | 96998 | 21 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
CHEMBL1256740 | 96998 | 21 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
CHEMBL27006 | 96998 | 21 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
135547943 | 34204 | 21 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 516 | 6 | 2 | 5 | 4.8 | C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm980299k | ||
CHEMBL142819 | 34204 | 21 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 516 | 6 | 2 | 5 | 4.8 | C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm980299k | ||
44456828 | 97131 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 490 | 4 | 0 | 2 | 5.8 | C[C@@H](O[C@H]1CN2C(=O)N(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL270751 | 97131 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 490 | 4 | 0 | 2 | 5.8 | C[C@@H](O[C@H]1CN2C(=O)N(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
44358610 | 29270 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 619 | 7 | 1 | 3 | 6.8 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL138463 | 29270 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 619 | 7 | 1 | 3 | 6.8 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
10531050 | 119846 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 567 | 12 | 2 | 5 | 4.1 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL353093 | 119846 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 567 | 12 | 2 | 5 | 4.1 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
18669087 | 98277 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 507 | 6 | 1 | 3 | 6.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL277880 | 98277 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 507 | 6 | 1 | 3 | 6.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
18669087 | 98277 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 507 | 6 | 1 | 3 | 6.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL277880 | 98277 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 507 | 6 | 1 | 3 | 6.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
44325035 | 111661 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 488 | 6 | 1 | 6 | 5.0 | COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3nc[nH]n3)C2c2ccccc2)C1 | 10.1016/s0960-894x(02)00509-7 | ||
CHEMBL329018 | 111661 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 488 | 6 | 1 | 6 | 5.0 | COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3nc[nH]n3)C2c2ccccc2)C1 | 10.1016/s0960-894x(02)00509-7 | ||
44415400 | 79683 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 461 | 5 | 1 | 3 | 5.9 | COC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL213134 | 79683 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 461 | 5 | 1 | 3 | 5.9 | COC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
9938657 | 59906 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 565 | 8 | 2 | 3 | 5.9 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 | 10.1021/jm00006a012 | ||
CHEMBL174038 | 59906 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 565 | 8 | 2 | 3 | 5.9 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 | 10.1021/jm00006a012 | ||
10502796 | 32098 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 431 | 5 | 0 | 2 | 5.9 | CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL141034 | 32098 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 431 | 5 | 0 | 2 | 5.9 | CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
11799022 | 4401 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 6.4 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
CHEMBL101763 | 4401 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 6.4 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
46881727 | 5518 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 570 | 7 | 2 | 4 | 5.6 | C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1077241 | 5518 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 570 | 7 | 2 | 4 | 5.6 | C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
15549737 | 178238 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 378 | 6 | 2 | 3 | 4.4 | COc1ccc(CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL469176 | 178238 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 378 | 6 | 2 | 3 | 4.4 | COc1ccc(CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
44593633 | 181860 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 404 | 5 | 2 | 3 | 4.9 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL478620 | 181860 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 404 | 5 | 2 | 3 | 4.9 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 | 10.1016/j.bmc.2008.06.047 | ||
44578056 | 189165 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 422 | 7 | 2 | 4 | 4.7 | COc1ccc(C(C)(OC)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL515935 | 189165 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 422 | 7 | 2 | 4 | 4.7 | COc1ccc(C(C)(OC)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/j.bmc.2008.06.047 | ||
19797472 | 118257 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 469 | 7 | 0 | 2 | 6.4 | Cc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc([Si](C)(C)C)c1 | 10.1021/jm00024a007 | ||
CHEMBL341863 | 118257 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 469 | 7 | 0 | 2 | 6.4 | Cc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc([Si](C)(C)C)c1 | 10.1021/jm00024a007 | ||
10341570 | 120561 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL357012 | 120561 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
2098 | 3638 | 31 | None | 1 | 6 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
58993655 | 121585 | 0 | None | - | 0 | Mongolian jird | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 486 | 6 | 1 | 3 | 6.4 | N#Cc1cc(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596486 | 121585 | 0 | None | - | 0 | Mongolian jird | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 486 | 6 | 1 | 3 | 6.4 | N#Cc1cc(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F | 10.1016/j.bmcl.2015.04.098 | ||
24752434 | 9045 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1099372 | 9045 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL2370435 | 208104 | 0 | None | 48 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O | 10.1021/jm8007618 | ||||
15639110 | 167579 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 438 | 7 | 1 | 3 | 5.6 | COc1ccccc1CN[C@H]1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL433020 | 167579 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 438 | 7 | 1 | 3 | 5.6 | COc1ccccc1CN[C@H]1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
44274544 | 81114 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 487 | 6 | 1 | 4 | 5.4 | Cn1c(-c2cccnc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21602 | 81114 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 487 | 6 | 1 | 4 | 5.4 | Cn1c(-c2cccnc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00183-4 | ||
44328469 | 111748 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 438 | 7 | 1 | 3 | 5.6 | COc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL329090 | 111748 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 438 | 7 | 1 | 3 | 5.6 | COc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
24782914 | 121581 | 0 | None | - | 0 | Mongolian jird | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 455 | 7 | 1 | 3 | 6.2 | COc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596482 | 121581 | 0 | None | - | 0 | Mongolian jird | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 455 | 7 | 1 | 3 | 6.2 | COc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
46884431 | 7972 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 563 | 5 | 0 | 2 | 7.8 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1091043 | 7972 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 563 | 5 | 0 | 2 | 7.8 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
10578269 | 34920 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 536 | 7 | 0 | 3 | 6.4 | O=C(Cc1ccncc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL143464 | 34920 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 536 | 7 | 0 | 3 | 6.4 | O=C(Cc1ccncc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
4898 | 2724 | 78 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 10.1016/j.bmc.2013.09.001 | ||
5742 | 2724 | 78 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 10.1016/j.bmc.2013.09.001 | ||
6451149 | 2724 | 78 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL206253 | 2724 | 78 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 10.1016/j.bmc.2013.09.001 | ||
DB09048 | 2724 | 78 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 10.1016/j.bmc.2013.09.001 | ||
10047566 | 164689 | 3 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
CHEMBL422931 | 164689 | 3 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
10047566 | 164689 | 3 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL422931 | 164689 | 3 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
44415840 | 79556 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 589 | 7 | 0 | 4 | 6.0 | C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCN(C)CC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL212663 | 79556 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 589 | 7 | 0 | 4 | 6.0 | C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCN(C)CC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
10049890 | 79602 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 460 | 7 | 2 | 3 | 4.6 | NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL212839 | 79602 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 460 | 7 | 2 | 3 | 4.6 | NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
10047566 | 164689 | 3 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL422931 | 164689 | 3 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL389652 | 210683 | 0 | None | 2 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
11813209 | 203389 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 509 | 9 | 3 | 4 | 6.4 | CC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 | 10.1021/jm010825z | ||
CHEMBL77684 | 203389 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 509 | 9 | 3 | 4 | 6.4 | CC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 | 10.1021/jm010825z | ||
18669072 | 82904 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 551 | 8 | 1 | 5 | 5.9 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CCO)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21909 | 82904 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 551 | 8 | 1 | 5 | 5.9 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CCO)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
10576865 | 206386 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 485 | 6 | 0 | 5 | 6.0 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
CHEMBL98022 | 206386 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 485 | 6 | 0 | 5 | 6.0 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
44433810 | 89449 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 583 | 5 | 0 | 3 | 5.2 | CC(=O)N1CCC(C(=O)N2C[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL237796 | 89449 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 583 | 5 | 0 | 3 | 5.2 | CC(=O)N1CCC(C(=O)N2C[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
9959724 | 164303 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 569 | 12 | 2 | 7 | 4.9 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-c2csnn2)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL42191 | 164303 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 569 | 12 | 2 | 7 | 4.9 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-c2csnn2)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
10531050 | 119846 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 567 | 12 | 2 | 5 | 4.1 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL353093 | 119846 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 567 | 12 | 2 | 5 | 4.1 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
489662 | 82614 | 2 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.2 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL21815 | 82614 | 2 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.2 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00616-3 | ||
132846 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL1256740 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL27006 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(98)00320-5 | ||
44297605 | 193020 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL53312 | 193020 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
132846 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL1256740 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL27006 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
9805809 | 102613 | 6 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 495 | 8 | 3 | 4 | 6.0 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm501535r | ||
CHEMBL307488 | 102613 | 6 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 495 | 8 | 3 | 4 | 6.0 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm501535r | ||
44338517 | 6258 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 4.9 | COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL108200 | 6258 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 4.9 | COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
9938657 | 59906 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 565 | 8 | 2 | 3 | 5.9 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 | 10.1021/jm00006a012 | ||
CHEMBL174038 | 59906 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 565 | 8 | 2 | 3 | 5.9 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 | 10.1021/jm00006a012 | ||
132846 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
CHEMBL1256740 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
CHEMBL27006 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
44346206 | 113162 | 3 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
CHEMBL332284 | 113162 | 3 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
132846 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80585-0 | ||
CHEMBL1256740 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80585-0 | ||
CHEMBL27006 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80585-0 | ||
10047567 | 205489 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.9 | FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80585-0 | ||
CHEMBL92701 | 205489 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.9 | FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80585-0 | ||
9890435 | 96994 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 460 | 6 | 1 | 3 | 4.9 | NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL27003 | 96994 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 460 | 6 | 1 | 3 | 4.9 | NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
132846 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL1256740 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL27006 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00220-N | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)80534-5 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)80534-5 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)80534-5 | ||
44458328 | 99054 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL283356 | 99054 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
11799022 | 4401 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 6.4 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL101763 | 4401 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 6.4 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
132846 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL1256740 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL27006 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
44458328 | 99054 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm9700171 | ||
CHEMBL283356 | 99054 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm9700171 | ||
44346206 | 113162 | 3 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL332284 | 113162 | 3 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
10576865 | 206386 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 485 | 6 | 0 | 5 | 6.0 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL98022 | 206386 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 485 | 6 | 0 | 5 | 6.0 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
10648551 | 206685 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 484 | 6 | 0 | 4 | 6.6 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL99873 | 206685 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 484 | 6 | 0 | 4 | 6.6 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
132846 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80280-8 | ||
CHEMBL1256740 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80280-8 | ||
CHEMBL27006 | 96998 | 21 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80280-8 | ||
489662 | 82614 | 2 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.2 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL21815 | 82614 | 2 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.2 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
489662 | 82614 | 2 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.2 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21815 | 82614 | 2 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.2 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
10648551 | 206685 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 484 | 6 | 0 | 4 | 6.6 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
CHEMBL99873 | 206685 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 484 | 6 | 0 | 4 | 6.6 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
24799545 | 86993 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 439 | 7 | 0 | 4 | 4.9 | CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333621 | 86993 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 439 | 7 | 0 | 4 | 4.9 | CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
44407321 | 74058 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 494 | 8 | 3 | 5 | 4.5 | O=C(O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL202568 | 74058 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 494 | 8 | 3 | 5 | 4.5 | O=C(O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 | 10.1016/j.bmcl.2005.11.026 | ||
44410193 | 139804 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 511 | 5 | 1 | 6 | 5.0 | Cn1nnc(C2CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2005.12.069 | ||
CHEMBL380684 | 139804 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 511 | 5 | 1 | 6 | 5.0 | Cn1nnc(C2CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2005.12.069 | ||
44297605 | 193020 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL53312 | 193020 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00319-9 | ||
44456580 | 154747 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 477 | 4 | 0 | 3 | 5.9 | C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL402895 | 154747 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 477 | 4 | 0 | 3 | 5.9 | C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
24889111 | 7842 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 7 | 1 | 4 | 7.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090287 | 7842 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 7 | 1 | 4 | 7.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
52947645 | 17061 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 596 | 5 | 0 | 4 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256586 | 17061 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 596 | 5 | 0 | 4 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
52948590 | 17125 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257235 | 17125 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
52943994 | 17650 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1258967 | 17650 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
10047566 | 164689 | 3 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL422931 | 164689 | 3 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
44458328 | 99054 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(00)80349-2 | ||
CHEMBL283356 | 99054 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(00)80349-2 | ||
46227361 | 200896 | 0 | None | 14 | 4 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL611925 | 200896 | 0 | None | 14 | 4 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL389652 | 210683 | 0 | None | -2 | 4 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800389v | ||||
44335318 | 5036 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 603 | 8 | 2 | 3 | 5.9 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(01)00631-x | ||
CHEMBL105600 | 5036 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 603 | 8 | 2 | 3 | 5.9 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(01)00631-x | ||
44312285 | 102484 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 703 | 7 | 2 | 4 | 7.6 | CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL306400 | 102484 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 703 | 7 | 2 | 4 | 7.6 | CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
10047566 | 164689 | 3 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1021/jm0311487 | ||
CHEMBL422931 | 164689 | 3 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1021/jm0311487 | ||
71450941 | 79109 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 595 | 5 | 2 | 3 | 6.2 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL2113739 | 79109 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 595 | 5 | 2 | 3 | 6.2 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 | 10.1016/s0960-894x(02)00382-7 | ||
44305248 | 201198 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 585 | 8 | 1 | 3 | 7.0 | CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL62679 | 201198 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 585 | 8 | 1 | 3 | 7.0 | CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 | 10.1016/s0960-894x(02)00382-7 | ||
9805809 | 102613 | 6 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 495 | 8 | 3 | 4 | 6.0 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm010825z | ||
CHEMBL307488 | 102613 | 6 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 495 | 8 | 3 | 4 | 6.0 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm010825z | ||
2098 | 3638 | 31 | None | -1 | 6 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.6b00381 | ||||
36511 | 3638 | 31 | None | -1 | 6 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.6b00381 | ||||
3805 | 3638 | 31 | None | -1 | 6 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.6b00381 | ||||
3835 | 3638 | 31 | None | -1 | 6 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.6b00381 | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 6 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.6b00381 | ||||
10837742 | 185283 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 4.1 | NC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1021/jm950654w | ||
CHEMBL48680 | 185283 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 4.1 | NC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1021/jm950654w | ||
44318685 | 204284 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 533 | 6 | 1 | 6 | 4.9 | CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3C(F)(F)F)CO2)C1c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL84881 | 204284 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 533 | 6 | 1 | 6 | 4.9 | CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3C(F)(F)F)CO2)C1c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
44408124 | 75050 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 629 | 5 | 0 | 3 | 7.2 | O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 | 10.1016/j.bmcl.2005.11.111 | ||
CHEMBL203961 | 75050 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 629 | 5 | 0 | 3 | 7.2 | O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 | 10.1016/j.bmcl.2005.11.111 | ||
58993471 | 121583 | 0 | None | - | 0 | Mongolian jird | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 468 | 6 | 1 | 3 | 6.2 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596484 | 121583 | 0 | None | - | 0 | Mongolian jird | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 468 | 6 | 1 | 3 | 6.2 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F | 10.1016/j.bmcl.2015.04.098 | ||
58993453 | 121587 | 0 | None | - | 0 | Mongolian jird | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 484 | 6 | 1 | 3 | 6.7 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596488 | 121587 | 0 | None | - | 0 | Mongolian jird | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 484 | 6 | 1 | 3 | 6.7 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2015.04.098 | ||
56662745 | 64312 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 499 | 6 | 0 | 3 | 6.0 | COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817889 | 64312 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 499 | 6 | 0 | 3 | 6.0 | COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817897 | 64312 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 499 | 6 | 0 | 3 | 6.0 | COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
44415415 | 78567 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 498 | 7 | 1 | 4 | 5.8 | CN(Cc1nc[nH]n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL211304 | 78567 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 498 | 7 | 1 | 4 | 5.8 | CN(Cc1nc[nH]n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
46884469 | 7911 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 594 | 6 | 0 | 4 | 7.2 | COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090651 | 7911 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 594 | 6 | 0 | 4 | 7.2 | COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 | 10.1016/j.bmcl.2010.01.120 | ||
46881779 | 8365 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1093750 | 8365 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
44306210 | 101917 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 596 | 8 | 2 | 7 | 2.9 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)OCCO2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL303896 | 101917 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 596 | 8 | 2 | 7 | 2.9 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)OCCO2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
44335372 | 4706 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 605 | 7 | 2 | 3 | 5.9 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 | 10.1016/s0960-894x(01)00631-x | ||
CHEMBL103979 | 4706 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 605 | 7 | 2 | 3 | 5.9 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 | 10.1016/s0960-894x(01)00631-x | ||
10414428 | 4784 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 523 | 4 | 1 | 4 | 5.7 | Cn1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c2cccnc2c1=O | 10.1021/jm00016a014 | ||
CHEMBL104301 | 4784 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 523 | 4 | 1 | 4 | 5.7 | Cn1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c2cccnc2c1=O | 10.1021/jm00016a014 | ||
44358603 | 118540 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 633 | 7 | 0 | 3 | 7.2 | CN(CC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL342662 | 118540 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 633 | 7 | 0 | 3 | 7.2 | CN(CC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
9959330 | 193884 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL554713 | 193884 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
2098 | 3638 | 31 | None | 1 | 6 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
10578969 | 56930 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 570 | 11 | 1 | 6 | 4.8 | COc1ccccc1CN(CC(Cc1csc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL165007 | 56930 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 570 | 11 | 1 | 6 | 4.8 | COc1ccccc1CN(CC(Cc1csc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
10626048 | 118065 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 530 | 9 | 0 | 3 | 6.1 | CN(C)CCCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL341599 | 118065 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 530 | 9 | 0 | 3 | 6.1 | CN(C)CCCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
490428 | 119071 | 6 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL346154 | 119071 | 6 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
44294535 | 103036 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 540 | 5 | 1 | 2 | 7.5 | CC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL3085128 | 103036 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 540 | 5 | 1 | 2 | 7.5 | CC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 | 10.1016/s0960-894x(02)00250-0 | ||
24801458 | 86996 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 433 | 6 | 0 | 4 | 4.9 | CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333624 | 86996 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 433 | 6 | 0 | 4 | 4.9 | CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
44407422 | 140832 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 571 | 9 | 3 | 7 | 3.5 | CS(=O)(=O)NC(=O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL383743 | 140832 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 571 | 9 | 3 | 7 | 3.5 | CS(=O)(=O)NC(=O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 | 10.1016/j.bmcl.2005.11.026 | ||
44410281 | 75217 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 525 | 5 | 1 | 6 | 5.5 | C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnnn1C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
CHEMBL204573 | 75217 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 525 | 5 | 1 | 6 | 5.5 | C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnnn1C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
58993670 | 121588 | 0 | None | - | 0 | Mongolian jird | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 464 | 6 | 1 | 3 | 6.4 | Cc1cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)ccc1C#N | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596489 | 121588 | 0 | None | - | 0 | Mongolian jird | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 464 | 6 | 1 | 3 | 6.4 | Cc1cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)ccc1C#N | 10.1016/j.bmcl.2015.04.098 | ||
57399170 | 71309 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 3.5 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917842 | 71309 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 3.5 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963612 | 71309 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 3.5 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
44456650 | 154956 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 551 | 5 | 1 | 4 | 6.7 | C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL404089 | 154956 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 551 | 5 | 1 | 4 | 6.7 | C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
52941570 | 17062 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256587 | 17062 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
52943848 | 17238 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257588 | 17238 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
10052312 | 106906 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 518 | 4 | 0 | 3 | 6.5 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL317896 | 106906 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 518 | 4 | 0 | 3 | 6.5 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
44338545 | 9245 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 500 | 6 | 1 | 3 | 4.2 | Brc1cc(I)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL111176 | 9245 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 500 | 6 | 1 | 3 | 4.2 | Brc1cc(I)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
9916428 | 112348 | 1 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 586 | 9 | 3 | 3 | 6.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 | 10.1021/jm9700171 | ||
CHEMBL330888 | 112348 | 1 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 586 | 9 | 3 | 3 | 6.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 | 10.1021/jm9700171 | ||
10793838 | 119581 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 611 | 13 | 2 | 7 | 3.6 | COC(=O)CC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL350846 | 119581 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 611 | 13 | 2 | 7 | 3.6 | COC(=O)CC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
9892852 | 83960 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL22194 | 83960 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
9890435 | 96994 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 460 | 6 | 1 | 3 | 4.9 | NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL27003 | 96994 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 460 | 6 | 1 | 3 | 4.9 | NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1021/jm9700171 | ||
44333692 | 4489 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 505 | 6 | 1 | 3 | 7.2 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Nc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL102434 | 4489 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 505 | 6 | 1 | 3 | 7.2 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Nc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
44270505 | 12260 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 470 | 9 | 2 | 3 | 4.1 | COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
CHEMBL1185492 | 12260 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 470 | 9 | 2 | 3 | 4.1 | COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
CHEMBL417263 | 12260 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 470 | 9 | 2 | 3 | 4.1 | COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
9890435 | 96994 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 460 | 6 | 1 | 3 | 4.9 | NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1021/jm9506534 | ||
CHEMBL27003 | 96994 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 460 | 6 | 1 | 3 | 4.9 | NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1021/jm9506534 | ||
9890435 | 96994 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 460 | 6 | 1 | 3 | 4.9 | NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL27003 | 96994 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 460 | 6 | 1 | 3 | 4.9 | NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
44318605 | 204151 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 425 | 3 | 1 | 4 | 4.5 | COc1ccc(C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL83772 | 204151 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 425 | 3 | 1 | 4 | 4.5 | COc1ccc(C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
44456894 | 159991 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 459 | 4 | 0 | 3 | 5.8 | C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL411242 | 159991 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 459 | 4 | 0 | 3 | 5.8 | C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
10049890 | 79602 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 460 | 7 | 2 | 3 | 4.6 | NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL212839 | 79602 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 460 | 7 | 2 | 3 | 4.6 | NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
22885690 | 141251 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 435 | 4 | 1 | 2 | 6.2 | C[C@@H](O[C@H]1CC[C@@H](N)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL386151 | 141251 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 435 | 4 | 1 | 2 | 6.2 | C[C@@H](O[C@H]1CC[C@@H](N)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
52942803 | 17064 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256589 | 17064 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
11756839 | 5127 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 532 | 4 | 0 | 3 | 6.8 | Cc1ccccc1-c1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 | 10.1021/jm00016a014 | ||
CHEMBL106087 | 5127 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 532 | 4 | 0 | 3 | 6.8 | Cc1ccccc1-c1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 | 10.1021/jm00016a014 | ||
9892852 | 83960 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm0311487 | ||
CHEMBL22194 | 83960 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm0311487 | ||
44358676 | 29797 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 599 | 7 | 0 | 5 | 6.1 | CN(CC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL138890 | 29797 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 599 | 7 | 0 | 5 | 6.1 | CN(CC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
9850771 | 119373 | 2 | None | - | 0 | Mouse | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL348976 | 119373 | 2 | None | - | 0 | Mouse | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
9892852 | 83960 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(00)80046-3 | ||
CHEMBL22194 | 83960 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(00)80046-3 | ||
44368171 | 45143 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 458 | 8 | 1 | 4 | 5.2 | CN(Cc1nc[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL152742 | 45143 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 458 | 8 | 1 | 4 | 5.2 | CN(Cc1nc[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
10460917 | 163197 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 583 | 11 | 2 | 4 | 5.5 | O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL420543 | 163197 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 583 | 11 | 2 | 4 | 5.5 | O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
9871754 | 5337 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
CHEMBL107172 | 5337 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
11568372 | 204306 | 3 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80280-8 | ||
CHEMBL85047 | 204306 | 3 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80280-8 | ||
44318672 | 204370 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 7 | 1 | 7 | 4.8 | CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3OC(F)(F)F)CO2)C1c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL85626 | 204370 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 7 | 1 | 7 | 4.8 | CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3OC(F)(F)F)CO2)C1c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
57390401 | 71263 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 2.9 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963299 | 71263 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 2.9 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL3216988 | 71263 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 2.9 | COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
44415986 | 79974 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 527 | 6 | 0 | 4 | 7.2 | C[C@@H](O[C@H]1CC[C@@H](N(C)c2cnccn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
CHEMBL214472 | 79974 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 527 | 6 | 0 | 4 | 7.2 | C[C@@H](O[C@H]1CC[C@@H](N(C)c2cnccn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.044 | ||
24889113 | 7866 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 571 | 5 | 0 | 4 | 6.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090450 | 7866 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 571 | 5 | 0 | 4 | 6.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1204418 | 7866 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 571 | 5 | 0 | 4 | 6.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
46881728 | 5519 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 628 | 9 | 2 | 6 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1077242 | 5519 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 628 | 9 | 2 | 6 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
44335319 | 107024 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 626 | 8 | 2 | 4 | 5.7 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00631-x | ||
CHEMBL318606 | 107024 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 626 | 8 | 2 | 4 | 5.7 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00631-x | ||
44370448 | 119254 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 717 | 18 | 1 | 5 | 8.1 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL347891 | 119254 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 717 | 18 | 1 | 5 | 8.1 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 | 10.1016/0960-894X(95)00080-D | ||
44358604 | 28309 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 559 | 7 | 0 | 5 | 5.2 | CC(C)N1CCN(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 | 10.1021/jm000986n | ||
CHEMBL137609 | 28309 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 559 | 7 | 0 | 5 | 5.2 | CC(C)N1CCN(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 | 10.1021/jm000986n | ||
44358732 | 31036 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 587 | 7 | 0 | 3 | 6.9 | Cc1c(F)cccc1C(CN(C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL140124 | 31036 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 587 | 7 | 0 | 3 | 6.9 | Cc1c(F)cccc1C(CN(C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44358428 | 118504 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 641 | 7 | 0 | 3 | 7.6 | CN(CC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL342607 | 118504 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 641 | 7 | 0 | 3 | 7.6 | CN(CC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
9871754 | 5337 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm990220r | ||
CHEMBL107172 | 5337 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm990220r | ||
2098 | 3638 | 31 | None | 1 | 6 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm900473p | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm900473p | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm900473p | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2009.08.035 | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2009.08.035 | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm101023r | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm101023r | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm101023r | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm100157m | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm100157m | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm100157m | ||
2098 | 3638 | 31 | None | -1 | 6 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990197+ | ||||
36511 | 3638 | 31 | None | -1 | 6 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990197+ | ||||
3805 | 3638 | 31 | None | -1 | 6 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990197+ | ||||
3835 | 3638 | 31 | None | -1 | 6 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990197+ | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 6 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990197+ | ||||
136180339 | 120591 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 406 | 8 | 2 | 5 | 4.2 | CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL357303 | 120591 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 406 | 8 | 2 | 5 | 4.2 | CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
10027219 | 99121 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 6.1 | NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL283872 | 99121 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 6.1 | NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
44274412 | 75685 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 483 | 7 | 1 | 4 | 5.4 | COc1ccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)cc1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL20572 | 75685 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 483 | 7 | 1 | 4 | 5.4 | COc1ccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)cc1 | 10.1016/s0960-894x(01)00183-4 | ||
44410283 | 137774 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 529 | 5 | 1 | 6 | 5.0 | Cn1nnc(C2(F)CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2005.12.069 | ||
CHEMBL377091 | 137774 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 529 | 5 | 1 | 6 | 5.0 | Cn1nnc(C2(F)CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2005.12.069 | ||
22293475 | 186545 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 620 | 6 | 1 | 2 | 8.8 | CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL49176 | 186545 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 620 | 6 | 1 | 2 | 8.8 | CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
44408295 | 139795 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 643 | 5 | 0 | 3 | 7.6 | O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 | 10.1016/j.bmcl.2005.11.111 | ||
CHEMBL380651 | 139795 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 643 | 5 | 0 | 3 | 7.6 | O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 | 10.1016/j.bmcl.2005.11.111 | ||
2098 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2011.02.031 | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2011.02.031 | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2011.02.031 | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2011.02.031 | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2011.02.031 | ||||
56662745 | 64312 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 499 | 6 | 0 | 3 | 6.0 | COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817889 | 64312 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 499 | 6 | 0 | 3 | 6.0 | COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817897 | 64312 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 499 | 6 | 0 | 3 | 6.0 | COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
2098 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2008.05.067 | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2008.05.067 | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2008.05.067 | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2008.05.067 | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2008.05.067 | ||||
44456625 | 168368 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 459 | 4 | 0 | 3 | 5.8 | C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL438759 | 168368 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 459 | 4 | 0 | 3 | 5.8 | C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
44415403 | 138166 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 500 | 7 | 2 | 3 | 5.4 | O=C1CC[C@@H](CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)N1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL377881 | 138166 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 500 | 7 | 2 | 3 | 5.4 | O=C1CC[C@@H](CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)N1 | 10.1016/j.bmcl.2006.06.035 | ||
52941489 | 17549 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 516 | 4 | 1 | 3 | 5.2 | C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1258623 | 17549 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 516 | 4 | 1 | 3 | 5.2 | C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
52941506 | 17585 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1258732 | 17585 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
46947062 | 17278 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257706 | 17278 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
71699792 | 124265 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 636 | 5 | 0 | 3 | 7.5 | CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | nan | ||
CHEMBL3642162 | 124265 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 636 | 5 | 0 | 3 | 7.5 | CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | nan | ||
19797432 | 37522 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 427 | 7 | 0 | 3 | 5.8 | COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL145800 | 37522 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 427 | 7 | 0 | 3 | 5.8 | COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
10438671 | 27141 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 607 | 7 | 0 | 3 | 7.2 | CN(CC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL136764 | 27141 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 607 | 7 | 0 | 3 | 7.2 | CN(CC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
44358707 | 31242 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 571 | 8 | 1 | 4 | 6.1 | COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 | 10.1021/jm000986n | ||
CHEMBL140299 | 31242 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 571 | 8 | 1 | 4 | 6.1 | COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 | 10.1021/jm000986n | ||
9850771 | 119373 | 2 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL348976 | 119373 | 2 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
10076881 | 162366 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 577 | 5 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL417407 | 162366 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 577 | 5 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 | 10.1016/s0960-894x(02)00382-7 | ||
10627355 | 119505 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 596 | 13 | 2 | 6 | 3.6 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C | 10.1021/jm950616c | ||
CHEMBL350151 | 119505 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 596 | 13 | 2 | 6 | 3.6 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C | 10.1021/jm950616c | ||
44338518 | 7641 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 466 | 6 | 1 | 3 | 5.5 | FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL108889 | 7641 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 466 | 6 | 1 | 3 | 5.5 | FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00563-2 | ||
44338359 | 162877 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 466 | 6 | 1 | 3 | 5.5 | FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL419742 | 162877 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 466 | 6 | 1 | 3 | 5.5 | FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00563-2 | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm800389v | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm800389v | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm800389v | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00006a012 | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00006a012 | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00006a012 | ||
132629 | 2206 | 10 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 508 | 6 | 1 | 2 | 5.7 | Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 | 10.1021/jm034219a | ||
2104 | 2206 | 10 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 508 | 6 | 1 | 2 | 5.7 | Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 | 10.1021/jm034219a | ||
CHEMBL24999 | 2206 | 10 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 508 | 6 | 1 | 2 | 5.7 | Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 | 10.1021/jm034219a | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00035a006 | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00035a006 | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00035a006 | ||
21050485 | 167402 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 540 | 5 | 1 | 3 | 6.4 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL431732 | 167402 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 540 | 5 | 1 | 3 | 6.4 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
24799366 | 86990 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 453 | 8 | 0 | 4 | 5.3 | CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333618 | 86990 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 453 | 8 | 0 | 4 | 5.3 | CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
10648288 | 101430 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 0 | 5 | 4.8 | COC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1021/jm950654w | ||
CHEMBL300856 | 101430 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 0 | 5 | 4.8 | COC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1021/jm950654w | ||
24785977 | 121555 | 0 | None | - | 0 | Mongolian jird | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 426 | 6 | 1 | 3 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccncc2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596456 | 121555 | 0 | None | - | 0 | Mongolian jird | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 426 | 6 | 1 | 3 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccncc2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
10414293 | 37220 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
CHEMBL145535 | 37220 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/s0960-894x(98)00395-3 | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/s0960-894x(98)00395-3 | ||
44396853 | 66937 | 7 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm0311487 | ||
CHEMBL188166 | 66937 | 7 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm0311487 | ||
21994307 | 26608 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 585 | 7 | 1 | 5 | 5.8 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL136305 | 26608 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 585 | 7 | 1 | 5 | 5.8 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44358471 | 29953 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 585 | 7 | 1 | 5 | 5.8 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL139015 | 29953 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 585 | 7 | 1 | 5 | 5.8 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00066a015 | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00066a015 | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00066a015 | ||
10394703 | 193297 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 669 | 9 | 1 | 5 | 6.3 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL54540 | 193297 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 669 | 9 | 1 | 5 | 6.3 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
135480369 | 33489 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 514 | 7 | 2 | 5 | 5.3 | Oc1n[nH]c(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)n1 | 10.1021/jm980376b | ||
CHEMBL142216 | 33489 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 514 | 7 | 2 | 5 | 5.3 | Oc1n[nH]c(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)n1 | 10.1021/jm980376b | ||
44274269 | 76678 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 563 | 7 | 1 | 4 | 7.1 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccccn3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL20717 | 76678 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 563 | 7 | 1 | 4 | 7.1 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccccn3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
22293476 | 79218 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 592 | 7 | 1 | 2 | 8.7 | Fc1ccc(C2CCN([C@H]3CC[C@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2115005 | 79218 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 592 | 7 | 1 | 2 | 8.7 | Fc1ccc(C2CCN([C@H]3CC[C@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 | 10.1016/s0960-894x(02)00249-4 | ||
24889283 | 8346 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 597 | 6 | 0 | 5 | 7.3 | CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1093595 | 8346 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 597 | 6 | 0 | 5 | 7.3 | CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 | 10.1016/j.bmcl.2010.01.120 | ||
52948931 | 17067 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 559 | 5 | 1 | 3 | 6.5 | CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256592 | 17067 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 559 | 5 | 1 | 3 | 6.5 | CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 | 10.1016/j.bmcl.2010.07.058 | ||
52941351 | 17196 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 531 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257466 | 17196 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 531 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
44306310 | 101850 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 588 | 8 | 2 | 5 | 4.3 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL303548 | 101850 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 588 | 8 | 2 | 5 | 4.3 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
44306023 | 101916 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 577 | 8 | 3 | 5 | 3.6 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL303890 | 101916 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 577 | 8 | 3 | 5 | 3.6 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
10100236 | 28601 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 607 | 7 | 0 | 3 | 7.2 | CN(CC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL137887 | 28601 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 607 | 7 | 0 | 3 | 7.2 | CN(CC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
44358470 | 29714 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 593 | 7 | 1 | 3 | 6.9 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL138825 | 29714 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 593 | 7 | 1 | 3 | 6.9 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44358561 | 30262 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 627 | 7 | 1 | 3 | 7.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL139286 | 30262 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 627 | 7 | 1 | 3 | 7.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
2098 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm000316h | ||||
10075595 | 60028 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 527 | 10 | 2 | 3 | 5.4 | CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL174526 | 60028 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 527 | 10 | 2 | 3 | 5.4 | CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
10554361 | 30645 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 536 | 7 | 0 | 3 | 6.4 | O=C(Cc1cccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL139719 | 30645 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 536 | 7 | 0 | 3 | 6.4 | O=C(Cc1cccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
10529338 | 31202 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 498 | 7 | 1 | 4 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3nc[nH]n3)CC2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
CHEMBL140263 | 31202 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 498 | 7 | 1 | 4 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3nc[nH]n3)CC2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
10840066 | 116220 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 536 | 7 | 0 | 3 | 6.4 | O=C(Cc1ccccn1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL337358 | 116220 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 536 | 7 | 0 | 3 | 6.4 | O=C(Cc1ccccn1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
71541574 | 86983 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 394 | 7 | 0 | 3 | 5.2 | CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333611 | 86983 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 394 | 7 | 0 | 3 | 5.2 | CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
44307181 | 202023 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 474 | 7 | 1 | 3 | 5.3 | NC(=O)CCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL67667 | 202023 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 474 | 7 | 1 | 3 | 5.3 | NC(=O)CCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
58993542 | 121594 | 0 | None | - | 0 | Mongolian jird | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 490 | 7 | 0 | 3 | 7.0 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(C4CC4)CC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596495 | 121594 | 0 | None | - | 0 | Mongolian jird | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 490 | 7 | 0 | 3 | 7.0 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(C4CC4)CC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
46884432 | 7840 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 588 | 5 | 0 | 3 | 7.7 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090285 | 7840 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 588 | 5 | 0 | 3 | 7.7 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
52947647 | 17065 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256590 | 17065 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
24752718 | 6465 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 542 | 5 | 0 | 5 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1082896 | 6465 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 542 | 5 | 0 | 5 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
24750734 | 7931 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1090742 | 7931 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
44306218 | 162024 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 554 | 8 | 3 | 6 | 2.8 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL416864 | 162024 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 554 | 8 | 3 | 6 | 2.8 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
44370973 | 46502 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 726 | 20 | 2 | 6 | 6.3 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL153976 | 46502 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 726 | 20 | 2 | 6 | 6.3 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 | 10.1016/0960-894X(95)00080-D | ||
44370354 | 120703 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 774 | 19 | 2 | 6 | 7.1 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)C(=O)OCc2ccccc2)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL357757 | 120703 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 774 | 19 | 2 | 6 | 7.1 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)C(=O)OCc2ccccc2)C1 | 10.1016/0960-894X(95)00080-D | ||
10462250 | 120879 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 683 | 18 | 1 | 5 | 7.5 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL358173 | 120879 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 683 | 18 | 1 | 5 | 7.5 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 | 10.1016/0960-894X(95)00080-D | ||
44358720 | 28288 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 609 | 7 | 0 | 3 | 6.8 | CN(CC(c1ccc(F)c(F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL137580 | 28288 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 609 | 7 | 0 | 3 | 6.8 | CN(CC(c1ccc(F)c(F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
44358657 | 30190 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 599 | 7 | 0 | 5 | 6.1 | CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL139226 | 30190 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 599 | 7 | 0 | 5 | 6.1 | CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
10816935 | 117604 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.2 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
CHEMBL340732 | 117604 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.2 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
46881821 | 5524 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 570 | 7 | 2 | 4 | 5.6 | C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1077281 | 5524 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 570 | 7 | 2 | 4 | 5.6 | C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
71541373 | 86997 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 463 | 6 | 0 | 4 | 5.0 | CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333625 | 86997 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 463 | 6 | 0 | 4 | 5.0 | CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
24800231 | 87009 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 422 | 6 | 0 | 3 | 5.3 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333637 | 87009 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 422 | 6 | 0 | 3 | 5.3 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
24785712 | 121590 | 0 | None | - | 0 | Mongolian jird | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 451 | 6 | 1 | 4 | 5.5 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cn1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596491 | 121590 | 0 | None | - | 0 | Mongolian jird | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 451 | 6 | 1 | 4 | 5.5 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cn1 | 10.1016/j.bmcl.2015.04.098 | ||
57393953 | 71271 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 460 | 7 | 1 | 7 | 3.7 | CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917849 | 71271 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 460 | 7 | 1 | 7 | 3.7 | CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963369 | 71271 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 460 | 7 | 1 | 7 | 3.7 | CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
44415443 | 77581 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 431 | 6 | 1 | 2 | 6.0 | CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL209531 | 77581 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 431 | 6 | 1 | 2 | 6.0 | CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
44415485 | 79500 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 474 | 8 | 2 | 3 | 4.9 | NC(=O)CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL212439 | 79500 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 474 | 8 | 2 | 3 | 4.9 | NC(=O)CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
44415502 | 79627 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 488 | 8 | 1 | 3 | 5.2 | CN(CC(N)=O)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL212919 | 79627 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 488 | 8 | 1 | 3 | 5.2 | CN(CC(N)=O)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
46884517 | 8008 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 643 | 7 | 0 | 4 | 8.0 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1091341 | 8008 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 643 | 7 | 0 | 4 | 8.0 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
24768572 | 7687 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 624 | 5 | 0 | 3 | 8.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089270 | 7687 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 624 | 5 | 0 | 3 | 8.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
52947645 | 17061 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 596 | 5 | 0 | 4 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256586 | 17061 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 596 | 5 | 0 | 4 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
46947062 | 17278 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1257706 | 17278 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 545 | 4 | 1 | 3 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
24752718 | 6465 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 542 | 5 | 0 | 5 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1082896 | 6465 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 542 | 5 | 0 | 5 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
19797432 | 37522 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 427 | 7 | 0 | 3 | 5.8 | COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL145800 | 37522 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 427 | 7 | 0 | 3 | 5.8 | COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
10650469 | 57138 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 557 | 10 | 2 | 4 | 4.7 | CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL165498 | 57138 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 557 | 10 | 2 | 4 | 4.7 | CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
44328374 | 206248 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 5.9 | COc1ccccc1CNC1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL97241 | 206248 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 5.9 | COc1ccccc1CNC1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
11755361 | 116068 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 491 | 8 | 3 | 3 | 5.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)cc1F)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL336439 | 116068 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 491 | 8 | 3 | 3 | 5.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)cc1F)c1ccccc1 | 10.1021/jm00022a010 | ||
15639149 | 112410 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 5.9 | COc1ccccc1CN[C@H]1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL331059 | 112410 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 5.9 | COc1ccccc1CN[C@H]1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
10413173 | 29445 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 487 | 8 | 3 | 3 | 5.7 | Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c(F)c1 | 10.1021/jm00022a010 | ||
CHEMBL138620 | 29445 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 487 | 8 | 3 | 3 | 5.7 | Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c(F)c1 | 10.1021/jm00022a010 | ||
44346149 | 15342 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 518 | 6 | 1 | 2 | 7.1 | FC(F)(F)c1cc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL121742 | 15342 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 518 | 6 | 1 | 2 | 7.1 | FC(F)(F)c1cc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
44346551 | 15406 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 481 | 8 | 0 | 2 | 7.0 | CN(C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL122119 | 15406 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 481 | 8 | 0 | 2 | 7.0 | CN(C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
10359664 | 113503 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 336 | 3 | 2 | 3 | 4.0 | COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 | 10.1021/jm9700171 | ||
CHEMBL332644 | 113503 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 336 | 3 | 2 | 3 | 4.0 | COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 | 10.1021/jm9700171 | ||
54581461 | 60934 | 0 | None | -6 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1143 | 29 | 10 | 12 | 4.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 | 10.1021/jm101023r | ||
CHEMBL1766207 | 60934 | 0 | None | -6 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1143 | 29 | 10 | 12 | 4.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 | 10.1021/jm101023r | ||
10254526 | 100030 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 479 | 7 | 0 | 1 | 6.9 | CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL291025 | 100030 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 479 | 7 | 0 | 1 | 6.9 | CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
44368083 | 44705 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.3 | Cn1nnnc1CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL152339 | 44705 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.3 | Cn1nnnc1CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
10457416 | 14717 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 470 | 7 | 2 | 2 | 5.5 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL120781 | 14717 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 470 | 7 | 2 | 2 | 5.5 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
10098987 | 59666 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 547 | 9 | 2 | 3 | 6.1 | O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL173396 | 59666 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 547 | 9 | 2 | 3 | 6.1 | O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
14986135 | 162849 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL419500 | 162849 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
44402934 | 70728 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 589 | 9 | 1 | 3 | 6.2 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 | 10.1021/jm058225d | ||
CHEMBL195222 | 70728 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 589 | 9 | 1 | 3 | 6.2 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 | 10.1021/jm058225d | ||
44359091 | 31033 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 505 | 8 | 3 | 3 | 6.4 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL140123 | 31033 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 505 | 8 | 3 | 3 | 6.4 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm00022a010 | ||
44346420 | 14190 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 473 | 5 | 0 | 3 | 4.8 | COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] | 10.1016/S0960-894X(01)80177-3 | ||
CHEMBL119990 | 14190 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 473 | 5 | 0 | 3 | 4.8 | COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] | 10.1016/S0960-894X(01)80177-3 | ||
44318657 | 204203 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 375 | 3 | 1 | 4 | 3.6 | COc1ccc(F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL84090 | 204203 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 375 | 3 | 1 | 4 | 3.6 | COc1ccc(F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL2371978 | 208427 | 0 | None | 30 | 3 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
18391045 | 99930 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 487 | 6 | 2 | 3 | 4.0 | NC(=O)CN[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL290043 | 99930 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 487 | 6 | 2 | 3 | 4.0 | NC(=O)CN[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
44288896 | 168421 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 517 | 5 | 1 | 3 | 6.2 | O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL43912 | 168421 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 517 | 5 | 1 | 3 | 6.2 | O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 | 10.1016/0960-894X(96)00287-9 | ||
19098237 | 36890 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 533 | 7 | 0 | 2 | 7.7 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
CHEMBL145265 | 36890 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 533 | 7 | 0 | 2 | 7.7 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
44312056 | 203016 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 595 | 7 | 2 | 4 | 6.2 | CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL74237 | 203016 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 595 | 7 | 2 | 4 | 6.2 | CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
44358585 | 31051 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 615 | 9 | 0 | 5 | 6.4 | COc1cccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC | 10.1021/jm000986n | ||
CHEMBL140134 | 31051 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 615 | 9 | 0 | 5 | 6.4 | COc1cccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC | 10.1021/jm000986n | ||
18709652 | 167723 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 515 | 12 | 2 | 5 | 4.3 | COc1ccc(OCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL434012 | 167723 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 515 | 12 | 2 | 5 | 4.3 | COc1ccc(OCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 | 10.1016/s0960-894x(01)00250-5 | ||
44306230 | 100288 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 594 | 8 | 2 | 6 | 4.4 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1csc2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL292799 | 100288 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 594 | 8 | 2 | 6 | 4.4 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1csc2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
44319057 | 204129 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 605 | 10 | 1 | 6 | 5.1 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL83585 | 204129 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 605 | 10 | 1 | 6 | 5.1 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
19049350 | 98823 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 7 | 1 | 2 | 6.4 | NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL281940 | 98823 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 7 | 1 | 2 | 6.4 | NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
19049350 | 98823 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 7 | 1 | 2 | 6.4 | NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL281940 | 98823 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 7 | 1 | 2 | 6.4 | NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
19049350 | 98823 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 7 | 1 | 2 | 6.4 | NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1021/jm0311487 | ||
CHEMBL281940 | 98823 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 7 | 1 | 2 | 6.4 | NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1021/jm0311487 | ||
44346694 | 114312 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 7 | 1 | 2 | 6.4 | N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL334072 | 114312 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 7 | 1 | 2 | 6.4 | N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
44289443 | 168506 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 502 | 11 | 2 | 5 | 4.4 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CSc1ccccn1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL43970 | 168506 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 502 | 11 | 2 | 5 | 4.4 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CSc1ccccn1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
44297749 | 192931 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3Cl)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL52892 | 192931 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3Cl)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44333579 | 4316 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 506 | 7 | 2 | 4 | 5.0 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(N)=O)cc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL101288 | 4316 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 506 | 7 | 2 | 4 | 5.0 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(N)=O)cc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
44338510 | 8546 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 5.0 | Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL109514 | 8546 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 5.0 | Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 | 10.1016/s0960-894x(02)00563-2 | ||
44338531 | 9268 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 408 | 6 | 1 | 3 | 5.4 | CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL111304 | 9268 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 408 | 6 | 1 | 3 | 5.4 | CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 | 10.1016/s0960-894x(02)00563-2 | ||
44322648 | 204595 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 386 | 6 | 1 | 3 | 4.1 | Cc1cc(C)cc(OCC(=O)N(Cc2cccc(Cl)c2)C2CCNCC2)c1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL87194 | 204595 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 386 | 6 | 1 | 3 | 4.1 | Cc1cc(C)cc(OCC(=O)N(Cc2cccc(Cl)c2)C2CCNCC2)c1 | 10.1016/s0960-894x(01)00727-2 | ||
44322525 | 204847 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 492 | 6 | 1 | 2 | 6.1 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL88810 | 204847 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 492 | 6 | 1 | 2 | 6.1 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
10095174 | 204937 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 446 | 5 | 1 | 3 | 5.5 | O=C(COc1cc(Cl)cc(Cl)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL89385 | 204937 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 446 | 5 | 1 | 3 | 5.5 | O=C(COc1cc(Cl)cc(Cl)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
44415470 | 165291 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.5 | N[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL424883 | 165291 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.5 | N[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
46884433 | 7841 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 581 | 5 | 0 | 2 | 7.9 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090286 | 7841 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 581 | 5 | 0 | 2 | 7.9 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44294395 | 186612 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 4.6 | CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
74972677 | 186612 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 4.6 | CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL49233 | 186612 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 4.6 | CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
15755315 | 162631 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 731 | 16 | 4 | 9 | 4.0 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1 | 10.1021/jm00089a011 | ||
CHEMBL418124 | 162631 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 731 | 16 | 4 | 9 | 4.0 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1 | 10.1021/jm00089a011 | ||
15755303 | 198664 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 596 | 15 | 4 | 7 | 3.1 | CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL59768 | 198664 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 596 | 15 | 4 | 7 | 3.1 | CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
15755300 | 201288 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 630 | 15 | 4 | 7 | 3.3 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL63059 | 201288 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 630 | 15 | 4 | 7 | 3.3 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
44337428 | 7155 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 578 | 8 | 2 | 3 | 5.2 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Br | 10.1021/jm970499g | ||
CHEMBL108575 | 7155 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 578 | 8 | 2 | 3 | 5.2 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Br | 10.1021/jm970499g | ||
10793341 | 108353 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 579 | 9 | 2 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc([N+](=O)[O-])cc1 | 10.1021/jm970499g | ||
CHEMBL320989 | 108353 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 579 | 9 | 2 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc([N+](=O)[O-])cc1 | 10.1021/jm970499g | ||
44411742 | 77900 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 441 | 4 | 1 | 3 | 4.5 | O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 | 10.1016/j.bmcl.2006.02.027 | ||
CHEMBL210811 | 77900 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 441 | 4 | 1 | 3 | 4.5 | O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 | 10.1016/j.bmcl.2006.02.027 | ||
44344435 | 12975 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 473 | 5 | 1 | 3 | 6.1 | Cc1cc(C)cc(C(=O)N2C3C=C(c4ccccc4)C2CC(NCc2ccnc4ccccc24)C3)c1 | 10.1016/S0960-894X(96)00623-3 | ||
CHEMBL119025 | 12975 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 473 | 5 | 1 | 3 | 6.1 | Cc1cc(C)cc(C(=O)N2C3C=C(c4ccccc4)C2CC(NCc2ccnc4ccccc24)C3)c1 | 10.1016/S0960-894X(96)00623-3 | ||
2125 | 2981 | 2 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 581 | 16 | 5 | 5 | 4.0 | NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C | 10.1016/S0960-894X(00)80360-1 | ||
5311350 | 2981 | 2 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 581 | 16 | 5 | 5 | 4.0 | NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C | 10.1016/S0960-894X(00)80360-1 | ||
CHEMBL444832 | 2981 | 2 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 581 | 16 | 5 | 5 | 4.0 | NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C | 10.1016/S0960-894X(00)80360-1 | ||
44291515 | 100669 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 580 | 17 | 4 | 5 | 4.6 | CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O | 10.1016/S0960-894X(00)80360-1 | ||
CHEMBL295301 | 100669 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 580 | 17 | 4 | 5 | 4.6 | CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O | 10.1016/S0960-894X(00)80360-1 | ||
44291788 | 100942 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 553 | 16 | 4 | 5 | 4.7 | CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO | 10.1016/S0960-894X(00)80360-1 | ||
CHEMBL297327 | 100942 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 553 | 16 | 4 | 5 | 4.7 | CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO | 10.1016/S0960-894X(00)80360-1 | ||
44346650 | 113940 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 322 | 3 | 2 | 3 | 4.0 | COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 | 10.1021/jm9700171 | ||
CHEMBL333308 | 113940 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 322 | 3 | 2 | 3 | 4.0 | COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 | 10.1021/jm9700171 | ||
15755305 | 100516 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 663 | 16 | 4 | 9 | 3.1 | CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL294288 | 100516 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 663 | 16 | 4 | 9 | 3.1 | CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
15755312 | 100591 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 621 | 14 | 4 | 9 | 1.8 | COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C | 10.1021/jm00089a011 | ||
CHEMBL294737 | 100591 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 621 | 14 | 4 | 9 | 1.8 | COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C | 10.1021/jm00089a011 | ||
15755330 | 201129 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 761 | 16 | 5 | 6 | 6.7 | O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL62349 | 201129 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 761 | 16 | 5 | 6 | 6.7 | O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 | 10.1021/jm00089a011 | ||
15755295 | 201576 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 595 | 15 | 4 | 8 | 1.0 | NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL64631 | 201576 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 595 | 15 | 4 | 8 | 1.0 | NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL1190873 | 206851 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 | 10.1021/jm00089a011 | ||||
CHEMBL541800 | 206851 | 0 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 | 10.1021/jm00089a011 | ||||
10840399 | 9285 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 549 | 9 | 2 | 4 | 4.4 | CN(Cc1ccncc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL111384 | 9285 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 549 | 9 | 2 | 4 | 4.4 | CN(Cc1ccncc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
15755333 | 100111 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 593 | 16 | 7 | 7 | -0.0 | NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm00089a011 | ||
CHEMBL291602 | 100111 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 593 | 16 | 7 | 7 | -0.0 | NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/jm00089a011 | ||
15755331 | 100381 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 761 | 16 | 5 | 6 | 6.7 | O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL293445 | 100381 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 761 | 16 | 5 | 6 | 6.7 | O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 | 10.1021/jm00089a011 | ||
15755294 | 201623 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 561 | 13 | 4 | 8 | 0.6 | CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL64829 | 201623 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 561 | 13 | 4 | 8 | 0.6 | CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL64601 | 214078 | 0 | None | - | 0 | Guinea pig | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | None | None | None | N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00089a011 | ||||
10744888 | 108180 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 534 | 8 | 2 | 3 | 5.0 | CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)c1ccccc1 | 10.1021/jm970499g | ||
CHEMBL320762 | 108180 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 534 | 8 | 2 | 3 | 5.0 | CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)c1ccccc1 | 10.1021/jm970499g | ||
44337578 | 167524 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 545 | 9 | 2 | 5 | 4.4 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
CHEMBL432620 | 167524 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 545 | 9 | 2 | 5 | 4.4 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
15485361 | 96781 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 576 | 9 | 0 | 3 | 7.5 | CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 | 10.1016/s0960-894x(98)00215-7 | ||
CHEMBL26860 | 96781 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 576 | 9 | 0 | 3 | 7.5 | CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 | 10.1016/s0960-894x(98)00215-7 | ||
10362340 | 89839 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 379 | 6 | 3 | 3 | 3.4 | CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
CHEMBL23851 | 89839 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 379 | 6 | 3 | 3 | 3.4 | CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
44274545 | 82099 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 561 | 8 | 0 | 4 | 7.3 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CC3CC3)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21775 | 82099 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 561 | 8 | 0 | 4 | 7.3 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CC3CC3)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
44362598 | 36593 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 443 | 5 | 0 | 2 | 5.9 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2Cc2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
CHEMBL145022 | 36593 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 443 | 5 | 0 | 2 | 5.9 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2Cc2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
10362340 | 89839 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 379 | 6 | 3 | 3 | 3.4 | CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL23851 | 89839 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 379 | 6 | 3 | 3 | 3.4 | CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1016/s0960-894x(98)00395-3 | ||
44312026 | 102378 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 439 | 7 | 2 | 2 | 4.8 | Cc1cc(C)cc(CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm00006a012 | ||
CHEMBL305608 | 102378 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 439 | 7 | 2 | 2 | 4.8 | Cc1cc(C)cc(CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm00006a012 | ||
44289232 | 169305 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 5.9 | O=C(c1ccccc1Cl)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL444043 | 169305 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 5.9 | O=C(c1ccccc1Cl)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
10349900 | 106267 | 0 | None | - | 3 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 716 | 13 | 3 | 7 | 2.8 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144343 | 106267 | 0 | None | - | 3 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 716 | 13 | 3 | 7 | 2.8 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL2369600 | 207889 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm960281e | ||||
10477952 | 98531 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 432 | 7 | 2 | 3 | 4.9 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(Cl)c1)c1ccccc1 | 10.1021/jm00035a006 | ||
CHEMBL279916 | 98531 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 432 | 7 | 2 | 3 | 4.9 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(Cl)c1)c1ccccc1 | 10.1021/jm00035a006 | ||
19797474 | 37238 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 419 | 6 | 0 | 2 | 5.8 | Fc1ccc(F)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL145552 | 37238 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 419 | 6 | 0 | 2 | 5.8 | Fc1ccc(F)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
44384902 | 59632 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 579 | 8 | 1 | 4 | 5.7 | COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL173245 | 59632 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 579 | 8 | 1 | 4 | 5.7 | COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/0960-894X(96)00148-5 | ||
44362586 | 37518 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 335 | 5 | 0 | 2 | 4.5 | Cc1cc(C)cc(COC2C3CCN(CC3)C2Cc2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL145799 | 37518 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 335 | 5 | 0 | 2 | 4.5 | Cc1cc(C)cc(COC2C3CCN(CC3)C2Cc2ccccc2)c1 | 10.1021/jm00024a007 | ||
44276673 | 96908 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 604 | 7 | 1 | 4 | 6.6 | O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(98)00215-7 | ||
CHEMBL26951 | 96908 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 604 | 7 | 1 | 4 | 6.6 | O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(98)00215-7 | ||
44324705 | 111865 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 804 | 16 | 0 | 4 | 9.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL329445 | 111865 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 804 | 16 | 0 | 4 | 9.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 | 10.1016/S0960-894X(01)80747-2 | ||
44359056 | 118945 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 513 | 9 | 3 | 5 | 5.1 | COC(=O)c1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 | 10.1021/jm00022a010 | ||
CHEMBL345069 | 118945 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 513 | 9 | 3 | 5 | 5.1 | COC(=O)c1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 | 10.1021/jm00022a010 | ||
10039383 | 85052 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 281 | 5 | 1 | 2 | 3.5 | c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 | 10.1021/jm9700171 | ||
CHEMBL22680 | 85052 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 281 | 5 | 1 | 2 | 3.5 | c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 | 10.1021/jm9700171 | ||
44297603 | 162578 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 635 | 9 | 1 | 5 | 5.7 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL417760 | 162578 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 635 | 9 | 1 | 5 | 5.7 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
11683136 | 105323 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.7 | N[C@@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126963 | 105323 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.7 | N[C@@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
44333708 | 162824 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(F)(F)F)cc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL419352 | 162824 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(F)(F)F)cc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
11489471 | 94439 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 532 | 6 | 0 | 3 | 7.4 | COCc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
CHEMBL25398 | 94439 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 532 | 6 | 0 | 3 | 7.4 | COCc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
10389968 | 59579 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 470 | 4 | 1 | 3 | 5.7 | CC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm00006a011 | ||
CHEMBL173014 | 59579 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 470 | 4 | 1 | 3 | 5.7 | CC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm00006a011 | ||
21753663 | 194980 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 373 | 9 | 1 | 2 | 4.8 | Cc1cc(C)cc(COCC(NC=O)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL56442 | 194980 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 373 | 9 | 1 | 2 | 4.8 | Cc1cc(C)cc(COCC(NC=O)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
71541576 | 86985 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 438 | 6 | 0 | 3 | 5.8 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333613 | 86985 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 438 | 6 | 0 | 3 | 5.8 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
24800927 | 87011 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 384 | 5 | 1 | 3 | 4.6 | FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333639 | 87011 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 384 | 5 | 1 | 3 | 4.6 | FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1016/j.bmcl.2012.11.094 | ||
44433783 | 89758 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 530 | 4 | 0 | 3 | 6.3 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL238209 | 89758 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 530 | 4 | 0 | 3 | 6.3 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
46883823 | 8347 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 586 | 5 | 1 | 4 | 6.0 | C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1093596 | 8347 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 586 | 5 | 1 | 4 | 6.0 | C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
11705241 | 87807 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 459 | 6 | 0 | 2 | 6.7 | CCN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347857 | 87807 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 459 | 6 | 0 | 2 | 6.7 | CCN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmc.2013.02.010 | ||
24993314 | 170472 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 569 | 5 | 0 | 3 | 8.1 | CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O | 10.1021/jm8016514 | ||
CHEMBL445686 | 170472 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 569 | 5 | 0 | 3 | 8.1 | CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O | 10.1021/jm8016514 | ||
44306115 | 201795 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 498 | 10 | 4 | 4 | 2.6 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CO)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL66151 | 201795 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 498 | 10 | 4 | 4 | 2.6 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CO)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
44324814 | 205476 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 606 | 16 | 1 | 4 | 6.2 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC)CC)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL92621 | 205476 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 606 | 16 | 1 | 4 | 6.2 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC)CC)C1 | 10.1016/S0960-894X(01)80747-2 | ||
44288901 | 162731 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 559 | 8 | 1 | 4 | 5.6 | CN(C)CCCOC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL418697 | 162731 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 559 | 8 | 1 | 4 | 5.6 | CN(C)CCCOC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
11318556 | 93501 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.9 | CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
CHEMBL24829 | 93501 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.9 | CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
10840688 | 119696 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 564 | 11 | 1 | 5 | 4.7 | COc1ccccc1CN(CC(Cc1ccc2ccccc2c1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL351940 | 119696 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 564 | 11 | 1 | 5 | 4.7 | COc1ccccc1CN(CC(Cc1ccc2ccccc2c1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
44299464 | 198083 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 385 | 7 | 1 | 2 | 5.7 | NC(COCc1cc(Cl)cc(Cl)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL59380 | 198083 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 385 | 7 | 1 | 2 | 5.7 | NC(COCc1cc(Cl)cc(Cl)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
44306211 | 101866 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 592 | 8 | 2 | 5 | 4.0 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)CCCC2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL303680 | 101866 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 592 | 8 | 2 | 5 | 4.0 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)CCCC2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
46884467 | 7909 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 582 | 5 | 0 | 3 | 7.3 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090649 | 7909 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 582 | 5 | 0 | 3 | 7.3 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
10202046 | 120548 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL356912 | 120548 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
10407571 | 167394 | 8 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80246-2 | ||
CHEMBL431690 | 167394 | 8 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80246-2 | ||
44307162 | 201669 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 493 | 6 | 0 | 2 | 7.6 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccccc3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL65153 | 201669 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 493 | 6 | 0 | 2 | 7.6 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccccc3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00009-I | ||
71583096 | 87792 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 445 | 5 | 0 | 2 | 6.3 | CN1CCCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347694 | 87792 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 445 | 5 | 0 | 2 | 6.3 | CN1CCCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmc.2013.02.010 | ||
15755296 | 101813 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 670 | 14 | 4 | 9 | 3.5 | C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL303337 | 101813 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 670 | 14 | 4 | 9 | 3.5 | C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
15755297 | 102186 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 656 | 14 | 4 | 9 | 3.1 | CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL304472 | 102186 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 656 | 14 | 4 | 9 | 3.1 | CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
10256518 | 96945 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 532 | 5 | 0 | 3 | 6.4 | CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00016a014 | ||
CHEMBL269781 | 96945 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 532 | 5 | 0 | 3 | 6.4 | CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00016a014 | ||
10363425 | 164056 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 397 | 4 | 1 | 3 | 4.9 | CN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL421591 | 164056 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 397 | 4 | 1 | 3 | 4.9 | CN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
44288846 | 167773 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 485 | 6 | 1 | 3 | 6.4 | O=C(c1cccc2ccccc12)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL43432 | 167773 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 485 | 6 | 1 | 3 | 6.4 | O=C(c1cccc2ccccc12)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
10317821 | 36558 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 383 | 6 | 0 | 2 | 5.5 | c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
CHEMBL144996 | 36558 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 383 | 6 | 0 | 2 | 5.5 | c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
44358472 | 116295 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 6.1 | COc1ccc(OC)c(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 | 10.1021/jm000986n | ||
CHEMBL337803 | 116295 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 6.1 | COc1ccc(OC)c(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 | 10.1021/jm000986n | ||
44294321 | 11945 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 492 | 4 | 0 | 4 | 6.5 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 | 10.1021/jm00109a034 | ||
54093758 | 11945 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 492 | 4 | 0 | 4 | 6.5 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1183502 | 11945 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 492 | 4 | 0 | 4 | 6.5 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL301168 | 11945 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 492 | 4 | 0 | 4 | 6.5 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 | 10.1021/jm00109a034 | ||
15037921 | 119120 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 444 | 8 | 1 | 2 | 6.2 | Clc1ccccc1CCCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL346626 | 119120 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 444 | 8 | 1 | 2 | 6.2 | Clc1ccccc1CCCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
68928842 | 124278 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 600 | 5 | 1 | 5 | 4.1 | CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 | nan | ||
CHEMBL3642175 | 124278 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 600 | 5 | 1 | 5 | 4.1 | CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 | nan | ||
44312218 | 202439 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 542 | 8 | 1 | 4 | 5.5 | CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL70461 | 202439 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 542 | 8 | 1 | 4 | 5.5 | CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
10506929 | 56285 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 | 10.1021/jm950616c | ||
CHEMBL164175 | 56285 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 | 10.1021/jm950616c | ||
44328416 | 206203 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 476 | 6 | 1 | 2 | 6.6 | FC(F)(F)c1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL96956 | 206203 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 476 | 6 | 1 | 2 | 6.6 | FC(F)(F)c1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
10039383 | 85052 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 281 | 5 | 1 | 2 | 3.5 | c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 | 10.1021/jm980376b | ||
CHEMBL22680 | 85052 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 281 | 5 | 1 | 2 | 3.5 | c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 | 10.1021/jm980376b | ||
19797452 | 121015 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 413 | 7 | 0 | 3 | 5.5 | COc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
CHEMBL358529 | 121015 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 413 | 7 | 0 | 3 | 5.5 | COc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
44287503 | 99743 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 465 | 7 | 1 | 1 | 6.6 | O=C(CC(c1ccccc1)c1ccccc1)NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL288340 | 99743 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 465 | 7 | 1 | 1 | 6.6 | O=C(CC(c1ccccc1)c1ccccc1)NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
44299829 | 197398 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.4 | FC(F)(F)c1cc(CC[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80534-5 | ||
CHEMBL58774 | 197398 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.4 | FC(F)(F)c1cc(CC[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80534-5 | ||
44287541 | 159110 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 465 | 6 | 0 | 1 | 6.6 | CN(CC(c1ccccc1)c1ccccc1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL41038 | 159110 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 465 | 6 | 0 | 1 | 6.6 | CN(CC(c1ccccc1)c1ccccc1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL449091 | 212210 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O | 10.1016/0960-894X(94)85022-4 | ||||
10692651 | 100620 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
CHEMBL294960 | 100620 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
19003165 | 101704 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 319 | 6 | 1 | 2 | 4.5 | Cc1cc(C)cc(COCC(N)Cc2cccc3ccccc23)c1 | 10.1016/S0960-894X(00)80063-3 | ||
CHEMBL302719 | 101704 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 319 | 6 | 1 | 2 | 4.5 | Cc1cc(C)cc(COCC(N)Cc2cccc3ccccc23)c1 | 10.1016/S0960-894X(00)80063-3 | ||
3198 | 203802 | 73 | None | -37 | 34 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | ||
CHEMBL1201049 | 203802 | 73 | None | -37 | 34 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | ||
CHEMBL808 | 203802 | 73 | None | -37 | 34 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | ||
44297683 | 167627 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL433285 | 167627 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
9869033 | 99958 | 3 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL290364 | 99958 | 3 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
71541468 | 87005 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 424 | 6 | 0 | 3 | 5.5 | CC(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333633 | 87005 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 424 | 6 | 0 | 3 | 5.5 | CC(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
24801626 | 87012 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 398 | 5 | 0 | 3 | 4.9 | CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333640 | 87012 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 398 | 5 | 0 | 3 | 4.9 | CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
57403990 | 70610 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 543 | 6 | 1 | 3 | 4.5 | CC(=O)NCC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951620 | 70610 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 543 | 6 | 1 | 3 | 4.5 | CC(=O)NCC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.11.048 | ||
44335410 | 4931 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 574 | 7 | 1 | 2 | 7.5 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(01)00631-x | ||
CHEMBL105009 | 4931 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 574 | 7 | 1 | 2 | 7.5 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(01)00631-x | ||
44288885 | 99820 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 500 | 8 | 1 | 4 | 4.9 | COc1cc(CC(=O)N[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)[C@H](Cc3ccccc3)C2)cc(OC)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL289026 | 99820 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 500 | 8 | 1 | 4 | 4.9 | COc1cc(CC(=O)N[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)[C@H](Cc3ccccc3)C2)cc(OC)c1 | 10.1016/0960-894X(96)00287-9 | ||
44396809 | 165814 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 462 | 6 | 1 | 2 | 6.5 | Cc1cc(C)cc(C(=O)N2CCC(NCc3cccc4ccccc34)CC2Cc2ccccc2)c1 | 10.1021/jm0311487 | ||
CHEMBL427514 | 165814 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 462 | 6 | 1 | 2 | 6.5 | Cc1cc(C)cc(C(=O)N2CCC(NCc3cccc4ccccc34)CC2Cc2ccccc2)c1 | 10.1021/jm0311487 | ||
44358709 | 29576 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 645 | 10 | 0 | 6 | 6.4 | COc1ccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC | 10.1021/jm000986n | ||
CHEMBL138715 | 29576 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 645 | 10 | 0 | 6 | 6.4 | COc1ccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC | 10.1021/jm000986n | ||
44358679 | 29642 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 611 | 6 | 0 | 4 | 7.4 | COc1ccccc1C(C1CCCCN1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL138770 | 29642 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 611 | 6 | 0 | 4 | 7.4 | COc1ccccc1C(C1CCCCN1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44358680 | 116104 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 608 | 8 | 1 | 3 | 6.8 | CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(Cc1c[nH]c2ccccc12)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL336715 | 116104 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 608 | 8 | 1 | 3 | 6.8 | CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(Cc1c[nH]c2ccccc12)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
44358683 | 118865 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 497 | 7 | 0 | 5 | 4.8 | CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Cl | 10.1021/jm000986n | ||
CHEMBL344434 | 118865 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 497 | 7 | 0 | 5 | 4.8 | CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Cl | 10.1021/jm000986n | ||
9869033 | 99958 | 3 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
CHEMBL290364 | 99958 | 3 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
9869033 | 99958 | 3 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00623-3 | ||
CHEMBL290364 | 99958 | 3 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00623-3 | ||
9910357 | 11874 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 427 | 7 | 1 | 2 | 5.2 | COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
CHEMBL1183052 | 11874 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 427 | 7 | 1 | 2 | 5.2 | COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
CHEMBL277524 | 11874 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 427 | 7 | 1 | 2 | 5.2 | COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
44338638 | 5647 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 452 | 6 | 1 | 3 | 4.4 | Brc1cc(Br)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL107829 | 5647 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 452 | 6 | 1 | 3 | 4.4 | Brc1cc(Br)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
44338546 | 108121 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 382 | 6 | 1 | 3 | 4.0 | Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL320535 | 108121 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 382 | 6 | 1 | 3 | 4.0 | Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00563-2 | ||
9917079 | 60837 | 33 | None | - | 0 | Mongolian jird | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 619 | 5 | 1 | 3 | 7.6 | O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765508 | 60837 | 33 | None | - | 0 | Mongolian jird | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 619 | 5 | 1 | 3 | 7.6 | O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 | 10.1016/j.bmc.2011.02.031 | ||
44346334 | 15076 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 586 | 9 | 3 | 3 | 6.0 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
CHEMBL121094 | 15076 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 586 | 9 | 3 | 3 | 6.0 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
10837362 | 30534 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 416 | 5 | 2 | 2 | 5.1 | FC(F)(F)c1cc(CNCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
CHEMBL139558 | 30534 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 416 | 5 | 2 | 2 | 5.1 | FC(F)(F)c1cc(CNCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
44299969 | 195520 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 373 | 9 | 1 | 2 | 5.6 | CCNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL56814 | 195520 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 373 | 9 | 1 | 2 | 5.6 | CCNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
44359117 | 118828 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 525 | 9 | 3 | 5 | 6.0 | COc1cccc2cc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)oc12 | 10.1021/jm00022a010 | ||
CHEMBL344217 | 118828 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 525 | 9 | 3 | 5 | 6.0 | COc1cccc2cc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)oc12 | 10.1021/jm00022a010 | ||
44297491 | 193680 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 578 | 10 | 1 | 7 | 3.6 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc([N+](=O)[O-])c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL55180 | 193680 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 578 | 10 | 1 | 7 | 3.6 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc([N+](=O)[O-])c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
76325557 | 105319 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 514 | 6 | 0 | 3 | 6.4 | CN1CCN(C2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126959 | 105319 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 514 | 6 | 0 | 3 | 6.4 | CN1CCN(C2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2014.01.036 | ||
76325558 | 105328 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 485 | 6 | 0 | 2 | 7.2 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)CC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126968 | 105328 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 485 | 6 | 0 | 2 | 7.2 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)CC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
490428 | 119071 | 6 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL346154 | 119071 | 6 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
22293473 | 79222 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 607 | 6 | 0 | 3 | 8.8 | O=C(OC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2115009 | 79222 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 607 | 6 | 0 | 3 | 8.8 | O=C(OC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
24783682 | 121558 | 0 | None | - | 0 | Mongolian jird | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 475 | 6 | 1 | 2 | 7.4 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3ccccc3c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596459 | 121558 | 0 | None | - | 0 | Mongolian jird | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 475 | 6 | 1 | 2 | 7.4 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3ccccc3c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
11724403 | 167980 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 | 10.1021/jm00024a007 | ||
CHEMBL435564 | 167980 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 | 10.1021/jm00024a007 | ||
9852911 | 98924 | 0 | None | 8 | 6 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 678 | 20 | 2 | 7 | 7.4 | NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 | 10.1021/jm000316h | ||
CHEMBL282618 | 98924 | 0 | None | 8 | 6 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 678 | 20 | 2 | 7 | 7.4 | NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 | 10.1021/jm000316h | ||
CHEMBL2372525 | 208525 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O | 10.1021/jm00037a009 | ||||
15118534 | 105709 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 467 | 0 | 1 | 5 | 4.6 | C#C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4Cc5nc6nc7ccccc7c(=O)n6cc5C[C@]4(C)[C@H]3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL3138259 | 105709 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 467 | 0 | 1 | 5 | 4.6 | C#C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4Cc5nc6nc7ccccc7c(=O)n6cc5C[C@]4(C)[C@H]3CC[C@@]21C | 10.1021/jm00080a025 | ||
11445389 | 187807 | 10 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 692 | 5 | 2 | 6 | 3.7 | CN1C(=O)[C@@H]2C[C@@]3([C@@]45C[C@H]6C(=O)N(C)[C@@H](Cc7ccccc7)C(=O)N6[C@@H]4Nc4ccccc45)c4ccccc4N[C@H]3N2C(=O)[C@@H]1Cc1ccccc1 | 10.1021/np50111a008 | ||
CHEMBL501675 | 187807 | 10 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 692 | 5 | 2 | 6 | 3.7 | CN1C(=O)[C@@H]2C[C@@]3([C@@]45C[C@H]6C(=O)N(C)[C@@H](Cc7ccccc7)C(=O)N6[C@@H]4Nc4ccccc45)c4ccccc4N[C@H]3N2C(=O)[C@@H]1Cc1ccccc1 | 10.1021/np50111a008 | ||
44287211 | 159988 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 451 | 5 | 0 | 1 | 6.9 | CN(C(=O)CC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL41124 | 159988 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 451 | 5 | 0 | 1 | 6.9 | CN(C(=O)CC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
16755229 | 173355 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 513 | 4 | 1 | 3 | 7.1 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2ccnc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL454087 | 173355 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 513 | 4 | 1 | 3 | 7.1 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2ccnc12 | 10.1016/j.bmc.2008.05.067 | ||
10435750 | 98799 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 365 | 6 | 1 | 2 | 4.1 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 | 10.1021/jm00035a006 | ||
CHEMBL281804 | 98799 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 365 | 6 | 1 | 2 | 4.1 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 | 10.1021/jm00035a006 | ||
10506124 | 100790 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
CHEMBL296228 | 100790 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
10435750 | 98799 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 365 | 6 | 1 | 2 | 4.1 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 | 10.1021/jm00066a015 | ||
CHEMBL281804 | 98799 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 365 | 6 | 1 | 2 | 4.1 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 | 10.1021/jm00066a015 | ||
44312952 | 104916 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 668 | 16 | 6 | 6 | 2.4 | CC(=O)NC(C(=O)NCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O | 10.1021/jm00068a003 | ||
CHEMBL311688 | 104916 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 668 | 16 | 6 | 6 | 2.4 | CC(=O)NC(C(=O)NCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O | 10.1021/jm00068a003 | ||
44322649 | 162819 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 494 | 6 | 1 | 3 | 5.5 | O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL419312 | 162819 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 494 | 6 | 1 | 3 | 5.5 | O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
44322524 | 204876 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 462 | 7 | 1 | 2 | 6.1 | Fc1ccc(CN(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL88998 | 204876 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 462 | 7 | 1 | 2 | 6.1 | Fc1ccc(CN(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 | 10.1016/s0960-894x(01)00727-2 | ||
44322704 | 204995 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 426 | 6 | 1 | 3 | 4.8 | O=C(COc1cc(Cl)cc(Cl)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL89847 | 204995 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 426 | 6 | 1 | 3 | 4.8 | O=C(COc1cc(Cl)cc(Cl)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
44346399 | 161120 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 536 | 9 | 3 | 3 | 4.8 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
CHEMBL413108 | 161120 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 536 | 9 | 3 | 3 | 4.8 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
44322678 | 204835 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 414 | 5 | 1 | 3 | 4.4 | O=C(COc1cc(F)cc(F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL88731 | 204835 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 414 | 5 | 1 | 3 | 4.4 | O=C(COc1cc(F)cc(F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
44346333 | 12945 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 572 | 10 | 3 | 3 | 6.5 | CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
CHEMBL1190061 | 12945 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 572 | 10 | 3 | 3 | 6.5 | CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
CHEMBL540060 | 12945 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 572 | 10 | 3 | 3 | 6.5 | CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
10530444 | 119695 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 537 | 11 | 2 | 4 | 4.1 | CC(=O)N(CCc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL351922 | 119695 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 537 | 11 | 2 | 4 | 4.1 | CC(=O)N(CCc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
44212284 | 59673 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 609 | 9 | 1 | 5 | 5.7 | COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL173420 | 59673 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 609 | 9 | 1 | 5 | 5.7 | COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 | 10.1016/0960-894X(96)00148-5 | ||
19797443 | 165059 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 408 | 6 | 0 | 3 | 5.4 | N#Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL424307 | 165059 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 408 | 6 | 0 | 3 | 5.4 | N#Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
10439730 | 106275 | 0 | None | 39 | 3 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 702 | 12 | 3 | 6 | 3.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144353 | 106275 | 0 | None | 39 | 3 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 702 | 12 | 3 | 6 | 3.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
44346302 | 112602 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(CO[C@@H]2/C(=C\c3ccccc3)N3CCC2CC3)c1 | 10.1021/jm9700171 | ||
CHEMBL331392 | 112602 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(CO[C@@H]2/C(=C\c3ccccc3)N3CCC2CC3)c1 | 10.1021/jm9700171 | ||
11724403 | 167980 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL435564 | 167980 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 | 10.1016/0960-894X(95)00205-8 | ||
44333821 | 4708 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 457 | 5 | 0 | 3 | 5.6 | CC(C)N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL103984 | 4708 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 457 | 5 | 0 | 3 | 5.6 | CC(C)N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00616-3 | ||
44297293 | 170261 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 617 | 9 | 1 | 5 | 5.7 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CSCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL445357 | 170261 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 617 | 9 | 1 | 5 | 5.7 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CSCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44368118 | 118979 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 473 | 8 | 0 | 6 | 4.6 | CN(Cc1nnnn1C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL345315 | 118979 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 473 | 8 | 0 | 6 | 4.6 | CN(Cc1nnnn1C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
22859115 | 205501 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 363 | 5 | 1 | 2 | 4.9 | N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL92818 | 205501 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 363 | 5 | 1 | 2 | 4.9 | N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
44334143 | 4506 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.5 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL102569 | 4506 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.5 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
22859115 | 205501 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 363 | 5 | 1 | 2 | 4.9 | N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL92818 | 205501 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 363 | 5 | 1 | 2 | 4.9 | N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
2090 | 2726 | 20 | None | - | 4 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
5311312 | 2726 | 20 | None | - | 4 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
CHEMBL437797 | 2726 | 20 | None | - | 4 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
132961 | 141570 | 14 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 561 | 7 | 1 | 4 | 6.6 | COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL38824 | 141570 | 14 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 561 | 7 | 1 | 4 | 6.6 | COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
24801795 | 87001 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 490 | 6 | 0 | 5 | 5.2 | CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)CC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333629 | 87001 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 490 | 6 | 0 | 5 | 5.2 | CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)CC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
44318405 | 105102 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 357 | 3 | 1 | 4 | 3.4 | COc1ccccc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL312202 | 105102 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 357 | 3 | 1 | 4 | 3.4 | COc1ccccc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
24784192 | 121570 | 0 | None | - | 0 | Mongolian jird | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 441 | 6 | 2 | 3 | 5.9 | Oc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596471 | 121570 | 0 | None | - | 0 | Mongolian jird | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 441 | 6 | 2 | 3 | 5.9 | Oc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
44297912 | 193021 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 527 | 10 | 1 | 5 | 5.0 | COc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL53314 | 193021 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 527 | 10 | 1 | 5 | 5.0 | COc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
44433786 | 146377 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 541 | 4 | 0 | 2 | 6.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)N2CCCCC2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL392567 | 146377 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 541 | 4 | 0 | 2 | 6.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)N2CCCCC2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
46883824 | 8348 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 583 | 5 | 1 | 3 | 7.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1093597 | 8348 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 583 | 5 | 1 | 3 | 7.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
52941570 | 17062 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256587 | 17062 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
52941550 | 17622 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1258852 | 17622 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
10251123 | 4769 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 412 | 6 | 1 | 4 | 5.1 | COc1ccccc1CNCc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL104225 | 4769 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 412 | 6 | 1 | 4 | 5.1 | COc1ccccc1CNCc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C | 10.1021/jm00016a014 | ||
44370893 | 119338 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 606 | 17 | 3 | 5 | 4.4 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCC(N)=O)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL348594 | 119338 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 606 | 17 | 3 | 5 | 4.4 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCC(N)=O)C1 | 10.1016/0960-894X(95)00080-D | ||
9869033 | 99958 | 3 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL290364 | 99958 | 3 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
71449177 | 79252 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 682 | 17 | 6 | 6 | 2.8 | CC(=O)N[C@H](C(=O)NCCCC[C@H](NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O | 10.1021/jm00068a003 | ||
CHEMBL2115161 | 79252 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 682 | 17 | 6 | 6 | 2.8 | CC(=O)N[C@H](C(=O)NCCCC[C@H](NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O | 10.1021/jm00068a003 | ||
71456198 | 78165 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 8 | 2 | 6 | 4.7 | COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL2112209 | 78165 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 8 | 2 | 6 | 4.7 | COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/s0960-894x(02)00382-7 | ||
44299583 | 101200 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 473 | 7 | 1 | 2 | 5.9 | NC(COCc1cc(Br)cc(Br)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL299275 | 101200 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 473 | 7 | 1 | 2 | 5.9 | NC(COCc1cc(Br)cc(Br)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
19968650 | 168799 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 363 | 5 | 1 | 2 | 4.9 | NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1021/jm980376b | ||
CHEMBL442028 | 168799 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 363 | 5 | 1 | 2 | 4.9 | NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1021/jm980376b | ||
44319222 | 105663 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 657 | 10 | 1 | 6 | 5.9 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL313546 | 105663 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 657 | 10 | 1 | 6 | 5.9 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
44326280 | 97627 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 297 | 5 | 1 | 2 | 4.5 | Cc1cc(COC[C@@H](N)c2ccccc2)cc(C(C)(C)C)c1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL273302 | 97627 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 297 | 5 | 1 | 2 | 4.5 | Cc1cc(COC[C@@H](N)c2ccccc2)cc(C(C)(C)C)c1 | 10.1016/0960-894X(95)00476-A | ||
49799942 | 10446 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 411 | 4 | 0 | 4 | 4.7 | Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
CHEMBL1169534 | 10446 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 411 | 4 | 0 | 4 | 4.7 | Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
44294194 | 176256 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 430 | 4 | 2 | 2 | 4.7 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1(c2ccccc2)CCNCC1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL46103 | 176256 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 430 | 4 | 2 | 2 | 4.7 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1(c2ccccc2)CCNCC1 | 10.1016/s0960-894x(02)00249-4 | ||
24783421 | 121562 | 0 | None | - | 0 | Mongolian jird | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 6 | 1 | 2 | 6.5 | Cc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596463 | 121562 | 0 | None | - | 0 | Mongolian jird | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 6 | 1 | 2 | 6.5 | Cc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
22850669 | 201297 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL63109 | 201297 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)80747-2 | ||
22850669 | 201297 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL63109 | 201297 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/0960-894X(95)00080-D | ||
44289169 | 101018 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL297883 | 101018 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
44358649 | 28576 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 631 | 9 | 1 | 3 | 7.5 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(C(c1ccccc1)c1ccccc1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL137868 | 28576 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 631 | 9 | 1 | 3 | 7.5 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(C(c1ccccc1)c1ccccc1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44358611 | 28897 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 580 | 8 | 2 | 4 | 6.1 | COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(O)(c2ccccc2)CC1 | 10.1021/jm000986n | ||
CHEMBL138130 | 28897 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 580 | 8 | 2 | 4 | 6.1 | COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(O)(c2ccccc2)CC1 | 10.1021/jm000986n | ||
44358673 | 31248 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 493 | 10 | 1 | 5 | 4.8 | COc1ccccc1C(CNC(=O)Cc1cccc(OC(C)C)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL140303 | 31248 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 493 | 10 | 1 | 5 | 4.8 | COc1ccccc1C(CNC(=O)Cc1cccc(OC(C)C)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
44289169 | 101018 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
CHEMBL297883 | 101018 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
44297728 | 100296 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 751 | 8 | 1 | 5 | 6.7 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL292874 | 100296 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 751 | 8 | 1 | 5 | 6.7 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44294416 | 183385 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 481 | 7 | 0 | 5 | 5.2 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
74972686 | 183385 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 481 | 7 | 0 | 5 | 5.2 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL48173 | 183385 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 481 | 7 | 0 | 5 | 5.2 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL406442 | 210861 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O | 10.1021/jm00037a009 | ||||
44458825 | 11885 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 438 | 3 | 0 | 3 | 6.8 | CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 | 10.1021/jm00085a015 | ||
54428149 | 11885 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 438 | 3 | 0 | 3 | 6.8 | CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 | 10.1021/jm00085a015 | ||
CHEMBL1183194 | 11885 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 438 | 3 | 0 | 3 | 6.8 | CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 | 10.1021/jm00085a015 | ||
CHEMBL283990 | 11885 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 438 | 3 | 0 | 3 | 6.8 | CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 | 10.1021/jm00085a015 | ||
132961 | 141570 | 14 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 561 | 7 | 1 | 4 | 6.6 | COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80178-5 | ||
CHEMBL38824 | 141570 | 14 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 561 | 7 | 1 | 4 | 6.6 | COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80178-5 | ||
10364942 | 92922 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 6 | 2 | 4 | 5.0 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 | 10.1021/jm00035a006 | ||
CHEMBL24549 | 92922 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 6 | 2 | 4 | 5.0 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 | 10.1021/jm00035a006 | ||
71456210 | 78248 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 293 | 2 | 1 | 2 | 4.1 | c1ccc([C@H]2COC3(CCCN[C@H]3c3ccccc3)C2)cc1 | 10.1016/s0960-894x(02)00509-7 | ||
CHEMBL2112367 | 78248 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 293 | 2 | 1 | 2 | 4.1 | c1ccc([C@H]2COC3(CCCN[C@H]3c3ccccc3)C2)cc1 | 10.1016/s0960-894x(02)00509-7 | ||
10364942 | 92922 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 6 | 2 | 4 | 5.0 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 | 10.1021/jm00066a015 | ||
CHEMBL24549 | 92922 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 6 | 2 | 4 | 5.0 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 | 10.1021/jm00066a015 | ||
49863733 | 15159 | 0 | None | 2 | 4 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 1477 | 21 | 11 | 14 | 6.8 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm100157m | ||
CHEMBL1214026 | 15159 | 0 | None | 2 | 4 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 1477 | 21 | 11 | 14 | 6.8 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm100157m | ||
44326290 | 205670 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 271 | 6 | 1 | 3 | 3.2 | COc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL93909 | 205670 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 271 | 6 | 1 | 3 | 3.2 | COc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 | 10.1016/0960-894X(95)00476-A | ||
44288789 | 100906 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 5.9 | O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL297134 | 100906 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 5.9 | O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
44386105 | 131408 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 621 | 10 | 1 | 4 | 6.4 | CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL369498 | 131408 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 621 | 10 | 1 | 4 | 6.4 | CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/0960-894X(96)00148-5 | ||
10429546 | 98600 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.2 | CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
CHEMBL280422 | 98600 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.2 | CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
46227361 | 200896 | 0 | None | -85 | 4 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL611925 | 200896 | 0 | None | -85 | 4 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
44289257 | 99886 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 435 | 6 | 1 | 3 | 5.2 | O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL289573 | 99886 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 435 | 6 | 1 | 3 | 5.2 | O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
44289257 | 99886 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 435 | 6 | 1 | 3 | 5.2 | O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL289573 | 99886 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 435 | 6 | 1 | 3 | 5.2 | O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1021/jm9700171 | ||
44288789 | 100906 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 5.9 | O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL297134 | 100906 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 5.9 | O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL2369603 | 207891 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm960281e | ||||
44306341 | 202050 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 499 | 9 | 2 | 4 | 2.6 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)Cc1ccccc1 | 10.1021/jm00039a022 | ||
CHEMBL67843 | 202050 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 499 | 9 | 2 | 4 | 2.6 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)Cc1ccccc1 | 10.1021/jm00039a022 | ||
10389745 | 100037 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 465 | 6 | 0 | 1 | 6.6 | CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL291074 | 100037 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 465 | 6 | 0 | 1 | 6.6 | CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
76318227 | 105324 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 459 | 7 | 1 | 2 | 6.7 | CCNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126964 | 105324 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 459 | 7 | 1 | 2 | 6.7 | CCNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2014.01.036 | ||
11612528 | 105335 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 6 | 0 | 2 | 6.8 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)C2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126974 | 105335 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 6 | 0 | 2 | 6.8 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)C2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
44334112 | 4971 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 513 | 6 | 1 | 3 | 7.0 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc3ccccc3c2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL105201 | 4971 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 513 | 6 | 1 | 3 | 7.0 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc3ccccc3c2)c1 | 10.1016/S0960-894X(96)00563-X | ||
44333950 | 107755 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 493 | 7 | 1 | 4 | 5.9 | COc1ccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)cc1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL319700 | 107755 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 493 | 7 | 1 | 4 | 5.9 | COc1ccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)cc1 | 10.1016/S0960-894X(96)00563-X | ||
44276728 | 167479 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 417 | 4 | 0 | 2 | 6.1 | CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL432279 | 167479 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 417 | 4 | 0 | 2 | 6.1 | CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
44299875 | 193120 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 373 | 8 | 0 | 2 | 5.6 | Cc1cc(C)cc(COC[C@@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL53846 | 193120 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 373 | 8 | 0 | 2 | 5.6 | Cc1cc(C)cc(COC[C@@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 | 10.1016/S0960-894X(01)80531-X | ||
44274167 | 83037 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 541 | 6 | 1 | 3 | 7.1 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3c(Cl)cc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL21991 | 83037 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 541 | 6 | 1 | 3 | 7.1 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3c(Cl)cc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
44276728 | 167479 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 417 | 4 | 0 | 2 | 6.1 | CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL432279 | 167479 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 417 | 4 | 0 | 2 | 6.1 | CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
56678621 | 66112 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 467 | 6 | 0 | 2 | 6.9 | O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817883 | 66112 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 467 | 6 | 0 | 2 | 6.9 | O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852017 | 66112 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 467 | 6 | 0 | 2 | 6.9 | O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
44306004 | 13223 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 539 | 13 | 4 | 4 | 3.8 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL1192152 | 13223 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 539 | 13 | 4 | 4 | 3.8 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL543338 | 13223 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 539 | 13 | 4 | 4 | 3.8 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
44306694 | 100337 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 556 | 8 | 2 | 5 | 3.3 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1F)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL293164 | 100337 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 556 | 8 | 2 | 5 | 3.3 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1F)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
44306354 | 201320 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 513 | 10 | 2 | 4 | 3.0 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCc1ccccc1 | 10.1021/jm00039a022 | ||
CHEMBL63249 | 201320 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 513 | 10 | 2 | 4 | 3.0 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCc1ccccc1 | 10.1021/jm00039a022 | ||
44312257 | 102437 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 567 | 7 | 2 | 4 | 5.6 | CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL306065 | 102437 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 567 | 7 | 2 | 4 | 5.6 | CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
44358602 | 27102 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 541 | 8 | 0 | 3 | 6.9 | CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC(c1ccccc1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL136734 | 27102 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 541 | 8 | 0 | 3 | 6.9 | CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC(c1ccccc1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44358596 | 29053 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 591 | 7 | 1 | 3 | 7.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL138269 | 29053 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 591 | 7 | 1 | 3 | 7.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
22293565 | 79294 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 607 | 6 | 0 | 3 | 8.7 | O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2115449 | 79294 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 607 | 6 | 0 | 3 | 8.7 | O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
44303850 | 100600 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 697 | 16 | 4 | 9 | 3.3 | CC(C)(C)OC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL294798 | 100600 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 697 | 16 | 4 | 9 | 3.3 | CC(C)(C)OC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
44303793 | 198437 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 709 | 13 | 3 | 9 | 3.6 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1Cc2ccccc2CC1C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL59615 | 198437 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 709 | 13 | 3 | 9 | 3.6 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1Cc2ccccc2CC1C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
68932793 | 124276 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 599 | 5 | 1 | 4 | 4.7 | CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 | nan | ||
CHEMBL3642173 | 124276 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 599 | 5 | 1 | 4 | 4.7 | CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 | nan | ||
44337795 | 108088 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 593 | 9 | 1 | 5 | 5.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
CHEMBL320308 | 108088 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 593 | 9 | 1 | 5 | 5.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
9978999 | 5410 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 411 | 4 | 2 | 3 | 5.1 | Cc1cc2c(-c3ccccc3)c(NC(=O)NCc3ccccc3)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
CHEMBL107618 | 5410 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 411 | 4 | 2 | 3 | 5.1 | Cc1cc2c(-c3ccccc3)c(NC(=O)NCc3ccccc3)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
44324710 | 111857 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 592 | 14 | 2 | 4 | 5.0 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNC(C)=O)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL329416 | 111857 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 592 | 14 | 2 | 4 | 5.0 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNC(C)=O)C1 | 10.1016/S0960-894X(01)80747-2 | ||
44358435 | 28506 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 599 | 7 | 1 | 5 | 5.8 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL137792 | 28506 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 599 | 7 | 1 | 5 | 5.8 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44381056 | 57305 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.6 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL166816 | 57305 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.6 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)80859-3 | ||
44294376 | 11947 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 482 | 7 | 1 | 5 | 5.1 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
53927094 | 11947 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 482 | 7 | 1 | 5 | 5.1 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1183513 | 11947 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 482 | 7 | 1 | 5 | 5.1 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL301946 | 11947 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 482 | 7 | 1 | 5 | 5.1 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
44294476 | 185626 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 497 | 9 | 3 | 3 | 6.5 | CC(NC(=O)[C@@](C)(Cc1cc2ccccc2[nH]1)NC(=O)OC(c1ccccc1)C(C)C)c1ccccc1 | 10.1016/0960-894X(95)00313-I | ||
CHEMBL48731 | 185626 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 497 | 9 | 3 | 3 | 6.5 | CC(NC(=O)[C@@](C)(Cc1cc2ccccc2[nH]1)NC(=O)OC(c1ccccc1)C(C)C)c1ccccc1 | 10.1016/0960-894X(95)00313-I | ||
132961 | 141570 | 14 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 561 | 7 | 1 | 4 | 6.6 | COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL38824 | 141570 | 14 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 561 | 7 | 1 | 4 | 6.6 | COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL264353 | 208873 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O | 10.1021/jm00037a009 | ||||
44346199 | 14132 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.6 | COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL119947 | 14132 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.6 | COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL2369630 | 207900 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm000316h | ||||
44358834 | 30367 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 525 | 9 | 3 | 5 | 6.0 | COc1ccc2oc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)cc2c1 | 10.1021/jm00022a010 | ||
CHEMBL139375 | 30367 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 525 | 9 | 3 | 5 | 6.0 | COc1ccc2oc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)cc2c1 | 10.1021/jm00022a010 | ||
44346199 | 14132 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.6 | COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 | 10.1021/jm9700171 | ||
CHEMBL119947 | 14132 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.6 | COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 | 10.1021/jm9700171 | ||
44433782 | 144934 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 516 | 4 | 1 | 3 | 6.0 | CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL391441 | 144934 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 516 | 4 | 1 | 3 | 6.0 | CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2007.08.028 | ||
9832198 | 106273 | 0 | None | - | 3 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 788 | 15 | 4 | 8 | 3.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144351 | 106273 | 0 | None | - | 3 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 788 | 15 | 4 | 8 | 3.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
16214865 | 172701 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 513 | 4 | 1 | 3 | 7.1 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cncc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL452531 | 172701 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 513 | 4 | 1 | 3 | 7.1 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cncc12 | 10.1016/j.bmc.2008.05.067 | ||
44346259 | 113618 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 425 | 7 | 3 | 2 | 4.4 | Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm00006a012 | ||
CHEMBL332796 | 113618 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 425 | 7 | 3 | 2 | 4.4 | Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm00006a012 | ||
44346259 | 113618 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 425 | 7 | 3 | 2 | 4.4 | Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm9700171 | ||
CHEMBL332796 | 113618 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 425 | 7 | 3 | 2 | 4.4 | Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm9700171 | ||
10767359 | 56208 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 489 | 11 | 2 | 4 | 3.7 | CCCCN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL163481 | 56208 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 489 | 11 | 2 | 4 | 3.7 | CCCCN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
44368082 | 44679 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.3 | Cn1nnc(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL152316 | 44679 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.3 | Cn1nnc(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 | 10.1016/s0960-894x(97)10163-9 | ||
44287609 | 99897 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 503 | 6 | 0 | 5 | 5.4 | COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL289666 | 99897 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 503 | 6 | 0 | 5 | 5.4 | COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
44274316 | 164863 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 579 | 8 | 0 | 6 | 6.1 | COC(=O)Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(c3ccccc3OC)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL423836 | 164863 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 579 | 8 | 0 | 6 | 6.1 | COC(=O)Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(c3ccccc3OC)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00183-4 | ||
56666212 | 64311 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 442 | 7 | 1 | 4 | 4.9 | COc1ccc(NC(C)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817896 | 64311 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 442 | 7 | 1 | 4 | 4.9 | COc1ccc(NC(C)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
52941489 | 17549 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 516 | 4 | 1 | 3 | 5.2 | C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1258623 | 17549 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 516 | 4 | 1 | 3 | 5.2 | C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL2112243 | 207486 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm960281e | ||||
21994365 | 25255 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 8 | 1 | 4 | 4.7 | COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL135028 | 25255 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 8 | 1 | 4 | 4.7 | COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
44358708 | 29575 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 665 | 8 | 0 | 3 | 8.6 | CC(C)C1CCN(C2CCN(C(CN(C)C(=O)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1021/jm000986n | ||
CHEMBL138714 | 29575 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 665 | 8 | 0 | 3 | 8.6 | CC(C)C1CCN(C2CCN(C(CN(C)C(=O)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1021/jm000986n | ||
44345148 | 10385 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 477 | 5 | 1 | 3 | 5.5 | Cc1cc(C)cc(C(=O)N2CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
CHEMBL116535 | 10385 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 477 | 5 | 1 | 3 | 5.5 | Cc1cc(C)cc(C(=O)N2CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
44458598 | 98392 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 6 | 1 | 4 | 5.7 | CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL278849 | 98392 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 6 | 1 | 4 | 5.7 | CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
9954221 | 15358 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 426 | 7 | 1 | 2 | 5.4 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCCc3ccccc3)C[C@H]2Cc2ccccc2)c1 | 10.1021/jm9700171 | ||
CHEMBL121852 | 15358 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 426 | 7 | 1 | 2 | 5.4 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCCc3ccccc3)C[C@H]2Cc2ccccc2)c1 | 10.1021/jm9700171 | ||
44359025 | 28923 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 485 | 9 | 3 | 4 | 5.3 | COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 | 10.1021/jm00022a010 | ||
CHEMBL138150 | 28923 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 485 | 9 | 3 | 4 | 5.3 | COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 | 10.1021/jm00022a010 | ||
44306435 | 96341 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 566 | 9 | 2 | 5 | 4.2 | CC(C)n1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 | 10.1021/jm00039a022 | ||
CHEMBL264821 | 96341 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 566 | 9 | 2 | 5 | 4.2 | CC(C)n1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 | 10.1021/jm00039a022 | ||
44368326 | 172057 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 413 | 7 | 0 | 3 | 5.5 | COc1ccccc1CO[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL449347 | 172057 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 413 | 7 | 0 | 3 | 5.5 | COc1ccccc1CO[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
44299750 | 193996 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 345 | 7 | 1 | 2 | 5.0 | Cc1ccc(C)c(COCC(N)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL55651 | 193996 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 345 | 7 | 1 | 2 | 5.0 | Cc1ccc(C)c(COCC(N)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
10483816 | 190604 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL51893 | 190604 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
10407571 | 167394 | 8 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80349-2 | ||
CHEMBL431690 | 167394 | 8 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80349-2 | ||
19797480 | 121032 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
CHEMBL358589 | 121032 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
10409595 | 4721 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 415 | 4 | 1 | 3 | 5.0 | CN(Cc1ccccc1)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL104075 | 4721 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 415 | 4 | 1 | 3 | 5.0 | CN(Cc1ccccc1)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
44358473 | 31249 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 609 | 7 | 0 | 3 | 7.4 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(CN1CCC(N2CCCCC2)CC1)c1ccccc1 | 10.1021/jm000986n | ||
CHEMBL140304 | 31249 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 609 | 7 | 0 | 3 | 7.4 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(CN1CCC(N2CCCCC2)CC1)c1ccccc1 | 10.1021/jm000986n | ||
44358801 | 118464 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 495 | 7 | 3 | 3 | 5.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1CCc2ccccc2C1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL342386 | 118464 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 495 | 7 | 3 | 3 | 5.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1CCc2ccccc2C1)c1ccccc1 | 10.1021/jm00022a010 | ||
14986146 | 44334 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 336 | 6 | 1 | 3 | 3.5 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1Cc1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL152011 | 44334 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 336 | 6 | 1 | 3 | 3.5 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1Cc1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
44297488 | 193438 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 558 | 9 | 1 | 6 | 3.6 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(C#N)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL54996 | 193438 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 558 | 9 | 1 | 6 | 3.6 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(C#N)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44297487 | 193608 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3Cl)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL55129 | 193608 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3Cl)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
10073370 | 59604 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 469 | 4 | 1 | 2 | 5.2 | CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 | 10.1021/jm00006a011 | ||
CHEMBL173120 | 59604 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 469 | 4 | 1 | 2 | 5.2 | CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 | 10.1021/jm00006a011 | ||
10045010 | 89760 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.2 | CC(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
CHEMBL23822 | 89760 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.2 | CC(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
44299854 | 100197 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.4 | FC(F)(F)c1cc(CC[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80534-5 | ||
CHEMBL292237 | 100197 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.4 | FC(F)(F)c1cc(CC[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80534-5 | ||
10041814 | 98418 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 322 | 5 | 2 | 3 | 3.4 | Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 | 10.1021/jm00035a006 | ||
CHEMBL279050 | 98418 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 322 | 5 | 2 | 3 | 3.4 | Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 | 10.1021/jm00035a006 | ||
10064734 | 122448 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 322 | 5 | 2 | 3 | 3.4 | Cc1cc(C)cc(COC(=O)[C@H](N)Cc2c[nH]c3ccccc23)c1 | 10.1021/jm0311487 | ||
CHEMBL360815 | 122448 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 322 | 5 | 2 | 3 | 3.4 | Cc1cc(C)cc(COC(=O)[C@H](N)Cc2c[nH]c3ccccc23)c1 | 10.1021/jm0311487 | ||
10041814 | 98418 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 322 | 5 | 2 | 3 | 3.4 | Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 | 10.1021/jm00066a015 | ||
CHEMBL279050 | 98418 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 322 | 5 | 2 | 3 | 3.4 | Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 | 10.1021/jm00066a015 | ||
1016 | 3690 | 75 | None | -39 | 35 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
2561 | 3690 | 75 | None | -39 | 35 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
2733526 | 3690 | 75 | None | -39 | 35 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
5384 | 3690 | 75 | None | -39 | 35 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
CHEMBL83 | 3690 | 75 | None | -39 | 35 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
DB00675 | 3690 | 75 | None | -39 | 35 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
44297424 | 190393 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 9 | 1 | 5 | 3.8 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(F)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL51863 | 190393 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 551 | 9 | 1 | 5 | 3.8 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(F)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
2247 | 502 | 77 | None | -117 | 41 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
249 | 502 | 77 | None | -117 | 41 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
2603 | 502 | 77 | None | -117 | 41 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
CHEMBL296419 | 502 | 77 | None | -117 | 41 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
DB00637 | 502 | 77 | None | -117 | 41 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
44358981 | 161123 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 546 | 10 | 4 | 4 | 5.5 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NC(=O)CCl)c1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL413122 | 161123 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 546 | 10 | 4 | 4 | 5.5 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NC(=O)CCl)c1)c1ccccc1 | 10.1021/jm00022a010 | ||
44346319 | 112957 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 597 | 9 | 3 | 6 | 5.9 | O=C(NC1(C(=O)N[C@@H](Cc2ccc3ccccc3c2)c2nnnn2Cc2ccccc2)CCCCC1)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
CHEMBL331925 | 112957 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 597 | 9 | 3 | 6 | 5.9 | O=C(NC1(C(=O)N[C@@H](Cc2ccc3ccccc3c2)c2nnnn2Cc2ccccc2)CCCCC1)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
12096357 | 55908 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 563 | 10 | 2 | 4 | 4.8 | CC(=O)N(Cc1ccccc1Cl)C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 | 10.1021/jm950616c | ||
CHEMBL162636 | 55908 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 563 | 10 | 2 | 4 | 4.8 | CC(=O)N(Cc1ccccc1Cl)C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 | 10.1021/jm950616c | ||
44368158 | 121253 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 473 | 8 | 0 | 6 | 4.6 | CN(Cc1nnn(C)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL358932 | 121253 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 473 | 8 | 0 | 6 | 4.6 | CN(Cc1nnn(C)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
11518191 | 105333 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 457 | 7 | 1 | 2 | 6.5 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)C2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126972 | 105333 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 457 | 7 | 1 | 2 | 6.5 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)C2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
76314660 | 105338 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 445 | 6 | 1 | 2 | 6.3 | CNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126977 | 105338 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 445 | 6 | 1 | 2 | 6.3 | CNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2014.01.036 | ||
11489240 | 94846 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 518 | 5 | 1 | 3 | 6.7 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 | 10.1021/jm034219a | ||
CHEMBL25639 | 94846 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 518 | 5 | 1 | 3 | 6.7 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 | 10.1021/jm034219a | ||
10407571 | 167394 | 8 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00092a009 | ||
CHEMBL431690 | 167394 | 8 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00092a009 | ||
44321456 | 204965 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 5.5 | CCOc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
CHEMBL89652 | 204965 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 426 | 8 | 1 | 3 | 5.5 | CCOc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
71541469 | 87006 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 438 | 7 | 0 | 3 | 5.6 | CC(C)Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333634 | 87006 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 438 | 7 | 0 | 3 | 5.6 | CC(C)Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
44318658 | 104304 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 387 | 4 | 1 | 5 | 3.4 | COc1ccc(OC)c([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL310896 | 104304 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 387 | 4 | 1 | 5 | 3.4 | COc1ccc(OC)c([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 | 10.1016/s0960-894x(02)00506-1 | ||
44415540 | 141272 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 488 | 5 | 0 | 2 | 6.2 | CN(C)C(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL386258 | 141272 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 488 | 5 | 0 | 2 | 6.2 | CN(C)C(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
71583094 | 87790 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 6.0 | FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347692 | 87790 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 6.0 | FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
71452663 | 78133 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 589 | 7 | 2 | 3 | 5.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(00)00260-2 | ||
CHEMBL2112070 | 78133 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 589 | 7 | 2 | 3 | 5.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(00)00260-2 | ||
11743207 | 4746 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 426 | 5 | 0 | 4 | 4.8 | COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL104165 | 4746 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 426 | 5 | 0 | 4 | 4.8 | COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
10342371 | 4875 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 425 | 4 | 1 | 3 | 5.5 | Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
CHEMBL104737 | 4875 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 425 | 4 | 1 | 3 | 5.5 | Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
44358710 | 30000 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 493 | 8 | 0 | 6 | 4.1 | COc1ccccc1CC(=O)N(C)CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL139057 | 30000 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 493 | 8 | 0 | 6 | 4.1 | COc1ccccc1CC(=O)N(C)CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
10531050 | 119846 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 567 | 12 | 2 | 5 | 4.1 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL353093 | 119846 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 567 | 12 | 2 | 5 | 4.1 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
118722856 | 115690 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 323 | 6 | 2 | 4 | 2.1 | N#CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1021/ml5002954 | ||
CHEMBL3358420 | 115690 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 323 | 6 | 2 | 4 | 2.1 | N#CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1021/ml5002954 | ||
44321408 | 106539 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 5.6 | CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL315435 | 106539 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 5.6 | CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
44321408 | 106539 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 5.6 | CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
CHEMBL315435 | 106539 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 410 | 7 | 1 | 2 | 5.6 | CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
15037920 | 45473 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 430 | 7 | 1 | 2 | 5.8 | Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL153042 | 45473 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 430 | 7 | 1 | 2 | 5.8 | Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
10531291 | 6495 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 579 | 9 | 2 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
CHEMBL108304 | 6495 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 579 | 9 | 2 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
44380707 | 120061 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.6 | COc1cccc([C@H]2[C@@H](NCc3ccccc3OC)C3CCN2CC3)c1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL354564 | 120061 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 352 | 6 | 1 | 4 | 3.6 | COc1cccc([C@H]2[C@@H](NCc3ccccc3OC)C3CCN2CC3)c1 | 10.1016/S0960-894X(01)80859-3 | ||
136056467 | 188612 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 366 | 4 | 0 | 5 | 3.4 | CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
49824386 | 188612 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 366 | 4 | 0 | 5 | 3.4 | CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL51135 | 188612 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 366 | 4 | 0 | 5 | 3.4 | CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
44348660 | 117543 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 389 | 0 | 1 | 4 | 4.1 | C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nccn6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL340394 | 117543 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 389 | 0 | 1 | 4 | 4.1 | C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nccn6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
2812 | 4711 | 96 | None | -43 | 34 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
CHEMBL104 | 4711 | 96 | None | -43 | 34 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
44404006 | 132235 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 549 | 7 | 1 | 3 | 5.7 | NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 | 10.1021/jm058225d | ||
CHEMBL370013 | 132235 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 549 | 7 | 1 | 3 | 5.7 | NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 | 10.1021/jm058225d | ||
10439730 | 106275 | 0 | None | - | 3 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 702 | 12 | 3 | 6 | 3.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144353 | 106275 | 0 | None | - | 3 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 702 | 12 | 3 | 6 | 3.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
44297705 | 190289 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 563 | 10 | 1 | 6 | 3.7 | COc1ccccc1CNC(COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL51849 | 190289 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 563 | 10 | 1 | 6 | 3.7 | COc1ccccc1CNC(COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(98)00320-5 | ||
71450949 | 79139 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 567 | 7 | 2 | 4 | 5.6 | CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL2114103 | 79139 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 567 | 7 | 2 | 4 | 5.6 | CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
10055415 | 106274 | 0 | None | 15 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 688 | 12 | 4 | 5 | 3.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144352 | 106274 | 0 | None | 15 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 688 | 12 | 4 | 5 | 3.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
10344874 | 119645 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 475 | 7 | 3 | 5 | 4.6 | O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] | 10.1016/s0960-894x(01)00044-0 | ||
CHEMBL351387 | 119645 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 475 | 7 | 3 | 5 | 4.6 | O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] | 10.1016/s0960-894x(01)00044-0 | ||
44386231 | 61051 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 607 | 8 | 1 | 4 | 6.3 | COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL176951 | 61051 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 607 | 8 | 1 | 4 | 6.3 | COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C | 10.1016/0960-894X(96)00148-5 | ||
15639102 | 114030 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 6 | 1 | 2 | 6.0 | c1ccc(CN[C@H]2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
CHEMBL333566 | 114030 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 6 | 1 | 2 | 6.0 | c1ccc(CN[C@H]2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
11433531 | 90697 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 618 | 7 | 1 | 3 | 9.4 | CC(C)(C)[Si](C)(C)OCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
CHEMBL23982 | 90697 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 618 | 7 | 1 | 3 | 9.4 | CC(C)(C)[Si](C)(C)OCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
9933653 | 98551 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 454 | 7 | 1 | 2 | 6.4 | OC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL28003 | 98551 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 454 | 7 | 1 | 2 | 6.4 | OC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
44299444 | 195513 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 346 | 7 | 1 | 2 | 5.0 | Cc1cc(C)cc(COCC(O)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL56811 | 195513 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 346 | 7 | 1 | 2 | 5.0 | Cc1cc(C)cc(COCC(O)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
58993503 | 121574 | 0 | None | - | 0 | Mongolian jird | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 483 | 7 | 1 | 4 | 6.0 | COC(=O)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596475 | 121574 | 0 | None | - | 0 | Mongolian jird | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 483 | 7 | 1 | 4 | 6.0 | COC(=O)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
44297858 | 155224 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 589 | 11 | 2 | 5 | 5.4 | CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL405820 | 155224 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 589 | 11 | 2 | 5 | 5.4 | CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
24992986 | 183722 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 4 | 0 | 2 | 7.1 | C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
CHEMBL484133 | 183722 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 4 | 0 | 2 | 7.1 | C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
18654565 | 167366 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 698 | 17 | 0 | 5 | 7.3 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2OC)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL431459 | 167366 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 698 | 17 | 0 | 5 | 7.3 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2OC)C1 | 10.1016/S0960-894X(01)80747-2 | ||
10370818 | 162101 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 571 | 6 | 1 | 3 | 7.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL416983 | 162101 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 571 | 6 | 1 | 3 | 7.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
44297708 | 193300 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 587 | 10 | 1 | 5 | 5.5 | CS(=O)(=O)N1CC2(CCN(C[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL54578 | 193300 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 587 | 10 | 1 | 5 | 5.5 | CS(=O)(=O)N1CC2(CCN(C[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
10834930 | 120987 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 365 | 6 | 1 | 3 | 4.4 | FC(F)(F)Oc1cccc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
CHEMBL358305 | 120987 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 365 | 6 | 1 | 3 | 4.4 | FC(F)(F)Oc1cccc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
44213477 | 204030 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 309 | 2 | 1 | 3 | 3.6 | c1ccc(C2CCC3(OCCNC3c3ccccc3)OC2)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL82692 | 204030 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 309 | 2 | 1 | 3 | 3.6 | c1ccc(C2CCC3(OCCNC3c3ccccc3)OC2)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
10369316 | 87796 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 517 | 5 | 0 | 3 | 7.2 | CC(C)(C)OC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347702 | 87796 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 517 | 5 | 0 | 3 | 7.2 | CC(C)(C)OC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmc.2013.02.010 | ||
44328401 | 112170 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 6 | 1 | 2 | 6.0 | c1ccc(CNC2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00044a002 | ||
CHEMBL330362 | 112170 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 6 | 1 | 2 | 6.0 | c1ccc(CNC2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00044a002 | ||
10835447 | 24531 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 411 | 4 | 0 | 4 | 4.7 | Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
CHEMBL134415 | 24531 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 411 | 4 | 0 | 4 | 4.7 | Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
71583093 | 87801 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 416 | 5 | 0 | 1 | 7.1 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347851 | 87801 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 416 | 5 | 0 | 1 | 7.1 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
15755313 | 101729 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 649 | 15 | 4 | 9 | 2.5 | CC(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C | 10.1021/jm00089a011 | ||
CHEMBL302844 | 101729 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 649 | 15 | 4 | 9 | 2.5 | CC(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C | 10.1021/jm00089a011 | ||
19797425 | 37184 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1C | 10.1021/jm00024a007 | ||
CHEMBL145500 | 37184 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1C | 10.1021/jm00024a007 | ||
CHEMBL64037 | 214075 | 0 | None | - | 0 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a011 | ||||
46227360 | 200895 | 0 | None | -151 | 4 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL611924 | 200895 | 0 | None | -151 | 4 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
44297680 | 100177 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL292156 | 100177 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL265155 | 208893 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | CSCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O | 10.1021/jm00037a009 | ||||
122182824 | 121577 | 0 | None | - | 0 | Mongolian jird | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 468 | 7 | 1 | 3 | 6.3 | CN(C)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596478 | 121577 | 0 | None | - | 0 | Mongolian jird | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 468 | 7 | 1 | 3 | 6.3 | CN(C)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
56681948 | 66137 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 436 | 6 | 0 | 4 | 5.1 | O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817882 | 66137 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 436 | 6 | 0 | 4 | 5.1 | O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852159 | 66137 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 436 | 6 | 0 | 4 | 5.1 | O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
44335466 | 4985 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 720 | 8 | 2 | 5 | 6.0 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 | 10.1016/s0960-894x(01)00631-x | ||
CHEMBL105295 | 4985 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 720 | 8 | 2 | 5 | 6.0 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 | 10.1016/s0960-894x(01)00631-x | ||
44358783 | 30454 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 8 | 3 | 3 | 5.9 | Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1C | 10.1021/jm00022a010 | ||
CHEMBL139471 | 30454 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 8 | 3 | 3 | 5.9 | Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1C | 10.1021/jm00022a010 | ||
11192771 | 93900 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 607 | 8 | 1 | 3 | 8.5 | CN(Cc1ccccc1)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
CHEMBL25065 | 93900 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 607 | 8 | 1 | 3 | 8.5 | CN(Cc1ccccc1)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
9985523 | 98704 | 0 | None | - | 5 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 572 | 17 | 2 | 6 | 6.2 | NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)C[C@@H]1OCc1ccccc1 | 10.1021/jm960281e | ||
CHEMBL281200 | 98704 | 0 | None | - | 5 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 572 | 17 | 2 | 6 | 6.2 | NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)C[C@@H]1OCc1ccccc1 | 10.1021/jm960281e | ||
24799546 | 86994 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 509 | 10 | 0 | 4 | 6.5 | CC(C)CN(CC(C)C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333622 | 86994 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 509 | 10 | 0 | 4 | 6.5 | CC(C)CN(CC(C)C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
58993452 | 121549 | 0 | None | - | 0 | Mongolian jird | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 431 | 6 | 1 | 6 | 3.8 | Cc1nnnn1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596450 | 121549 | 0 | None | - | 0 | Mongolian jird | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 431 | 6 | 1 | 6 | 3.8 | Cc1nnnn1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
44458786 | 11049 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 438 | 3 | 0 | 3 | 6.9 | CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 | 10.1021/jm00085a015 | ||
CHEMBL1178356 | 11049 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 438 | 3 | 0 | 3 | 6.9 | CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 | 10.1021/jm00085a015 | ||
CHEMBL23096 | 11049 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 438 | 3 | 0 | 3 | 6.9 | CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 | 10.1021/jm00085a015 | ||
44349033 | 16610 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 453 | 0 | 1 | 4 | 5.6 | CC#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL124532 | 16610 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 453 | 0 | 1 | 4 | 5.6 | CC#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
22869971 | 164716 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 430 | 3 | 1 | 2 | 4.9 | N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL42306 | 164716 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 430 | 3 | 1 | 2 | 4.9 | N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
9981979 | 98701 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 466 | 7 | 2 | 3 | 5.3 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1C(F)(F)F)c1ccccc1 | 10.1021/jm00035a006 | ||
CHEMBL281194 | 98701 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 466 | 7 | 2 | 3 | 5.3 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1C(F)(F)F)c1ccccc1 | 10.1021/jm00035a006 | ||
44318349 | 204345 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 357 | 3 | 1 | 4 | 3.4 | COc1cccc([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL85414 | 204345 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 357 | 3 | 1 | 4 | 3.4 | COc1cccc([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 | 10.1016/s0960-894x(02)00506-1 | ||
44277742 | 100307 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80349-2 | ||
CHEMBL29293 | 100307 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80349-2 | ||
44321457 | 167631 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00092a009 | ||
CHEMBL433336 | 167631 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00092a009 | ||
11633082 | 105322 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.7 | N[C@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126962 | 105322 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.7 | N[C@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
10650263 | 25882 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 547 | 4 | 0 | 4 | 6.8 | Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
CHEMBL135572 | 25882 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 547 | 4 | 0 | 4 | 6.8 | Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
10501444 | 101407 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
CHEMBL300722 | 101407 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
135890952 | 204377 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 406 | 4 | 2 | 6 | 3.4 | Oc1n[nH]c(CN2CCOC3(CCC(c4ccccc4)CO3)C2c2ccccc2)n1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL85674 | 204377 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 406 | 4 | 2 | 6 | 3.4 | Oc1n[nH]c(CN2CCOC3(CCC(c4ccccc4)CO3)C2c2ccccc2)n1 | 10.1016/s0960-894x(02)00506-1 | ||
11225834 | 98752 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 502 | 4 | 0 | 2 | 7.5 | Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL281491 | 98752 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 502 | 4 | 0 | 2 | 7.5 | Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
10364638 | 14489 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL120546 | 14489 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
10094248 | 4718 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 430 | 4 | 0 | 3 | 5.4 | Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2Cl)n(C)c(=O)c2ccccc12 | 10.1021/jm00016a014 | ||
CHEMBL104060 | 4718 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 430 | 4 | 0 | 3 | 5.4 | Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2Cl)n(C)c(=O)c2ccccc12 | 10.1021/jm00016a014 | ||
10006814 | 5171 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 518 | 4 | 0 | 3 | 6.5 | CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00016a014 | ||
CHEMBL106326 | 5171 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 518 | 4 | 0 | 3 | 6.5 | CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00016a014 | ||
44288548 | 100788 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cc4ccccc4cn3)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL296213 | 100788 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cc4ccccc4cn3)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
44288790 | 169786 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 472 | 4 | 1 | 2 | 5.1 | CC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL44474 | 169786 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 472 | 4 | 1 | 2 | 5.1 | CC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
21994270 | 26887 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 501 | 7 | 1 | 3 | 6.0 | Cc1cc(C)cc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 | 10.1021/jm000986n | ||
CHEMBL136544 | 26887 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 501 | 7 | 1 | 3 | 6.0 | Cc1cc(C)cc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 | 10.1021/jm000986n | ||
44312953 | 202852 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 682 | 17 | 6 | 6 | 2.8 | CC(=O)NC(C(=O)NCCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O | 10.1021/jm00068a003 | ||
CHEMBL72951 | 202852 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 682 | 17 | 6 | 6 | 2.8 | CC(=O)NC(C(=O)NCCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O | 10.1021/jm00068a003 | ||
44359088 | 118279 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 8 | 3 | 3 | 5.3 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL342044 | 118279 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 8 | 3 | 3 | 5.3 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)c1ccccc1 | 10.1021/jm00022a010 | ||
178025 | 118648 | 4 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 8 | 3 | 3 | 5.6 | Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 | 10.1021/jm00022a010 | ||
CHEMBL342924 | 118648 | 4 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 8 | 3 | 3 | 5.6 | Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 | 10.1021/jm00022a010 | ||
44305927 | 100146 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 541 | 8 | 2 | 5 | 3.9 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cc2ccccc2s1 | 10.1021/jm00039a022 | ||
CHEMBL291868 | 100146 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 541 | 8 | 2 | 5 | 3.9 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cc2ccccc2s1 | 10.1021/jm00039a022 | ||
44359111 | 118386 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 470 | 8 | 4 | 4 | 4.9 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(N)c1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL342260 | 118386 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 470 | 8 | 4 | 4 | 4.9 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(N)c1)c1ccccc1 | 10.1021/jm00022a010 | ||
10364638 | 14489 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL120546 | 14489 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
44346320 | 112958 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 586 | 9 | 3 | 3 | 6.1 | CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 | 10.1021/jm9700171 | ||
CHEMBL331926 | 112958 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 586 | 9 | 3 | 3 | 6.1 | CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 | 10.1021/jm9700171 | ||
44321442 | 204530 | 1 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm9700171 | ||
CHEMBL86806 | 204530 | 1 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm9700171 | ||
44334098 | 5047 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 477 | 7 | 1 | 3 | 6.2 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CCc2ccccc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL105631 | 5047 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 477 | 7 | 1 | 3 | 6.2 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CCc2ccccc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
44321457 | 167631 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
CHEMBL433336 | 167631 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
9892852 | 83960 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL22194 | 83960 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
44458328 | 99054 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL283356 | 99054 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1016/0960-894X(95)00205-8 | ||
44458983 | 99144 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 473 | 6 | 2 | 4 | 4.4 | CC(=O)N[C@@H](Cc1n[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00035a006 | ||
CHEMBL283989 | 99144 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 473 | 6 | 2 | 4 | 4.4 | CC(=O)N[C@@H](Cc1n[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00035a006 | ||
44458351 | 98931 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 443 | 5 | 0 | 2 | 5.9 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL282657 | 98931 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 443 | 5 | 0 | 2 | 5.9 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00205-8 | ||
44277478 | 166853 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1C | 10.1016/S0960-894X(00)80349-2 | ||
CHEMBL429610 | 166853 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1C | 10.1016/S0960-894X(00)80349-2 | ||
19797429 | 169883 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 428 | 7 | 0 | 4 | 5.4 | O=[N+]([O-])c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL444872 | 169883 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 428 | 7 | 0 | 4 | 5.4 | O=[N+]([O-])c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
10745241 | 110042 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 549 | 8 | 3 | 4 | 4.8 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N | 10.1021/jm970499g | ||
CHEMBL325116 | 110042 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 549 | 8 | 3 | 4 | 4.8 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N | 10.1021/jm970499g | ||
CHEMBL2369606 | 207894 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm960281e | ||||
44338530 | 9267 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 332 | 6 | 1 | 3 | 3.1 | Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL111303 | 9267 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 332 | 6 | 1 | 3 | 3.1 | Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
44322429 | 204541 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 480 | 5 | 1 | 3 | 5.5 | O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1cccc(Cl)c1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL86890 | 204541 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 480 | 5 | 1 | 3 | 5.5 | O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1cccc(Cl)c1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
44322610 | 204919 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 462 | 5 | 1 | 2 | 5.6 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL89245 | 204919 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 462 | 5 | 1 | 2 | 5.6 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
44346330 | 14398 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 522 | 9 | 4 | 3 | 4.5 | O=C(N[C@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
CHEMBL120441 | 14398 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 522 | 9 | 4 | 3 | 4.5 | O=C(N[C@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
18669055 | 4542 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 485 | 5 | 0 | 3 | 6.3 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(C)(C)C)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL102811 | 4542 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 485 | 5 | 0 | 3 | 6.3 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(C)(C)C)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
136180338 | 164634 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 502 | 10 | 2 | 5 | 5.7 | CCCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL422862 | 164634 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 502 | 10 | 2 | 5 | 5.7 | CCCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
11757401 | 59631 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 555 | 9 | 2 | 4 | 4.8 | O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL173231 | 59631 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 555 | 9 | 2 | 4 | 4.8 | O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
9892852 | 83960 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL22194 | 83960 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00205-8 | ||
44458328 | 99054 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL283356 | 99054 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL281971 | 209102 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm9800346 | ||||
44287803 | 99747 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 456 | 5 | 1 | 4 | 5.0 | COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL288371 | 99747 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 456 | 5 | 1 | 4 | 5.0 | COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
25176461 | 86975 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 404 | 6 | 0 | 3 | 5.2 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333604 | 86975 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 404 | 6 | 0 | 3 | 5.2 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
25176462 | 86976 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 390 | 6 | 1 | 3 | 4.8 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(C2CC2)c1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333605 | 86976 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 390 | 6 | 1 | 3 | 4.8 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(C2CC2)c1 | 10.1016/j.bmcl.2012.11.094 | ||
58993541 | 121595 | 0 | None | - | 0 | Mongolian jird | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 540 | 8 | 0 | 3 | 8.0 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(Cc4ccccc4)CC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596496 | 121595 | 0 | None | - | 0 | Mongolian jird | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 540 | 8 | 0 | 3 | 8.0 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(Cc4ccccc4)CC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
136043848 | 77597 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 528 | 8 | 2 | 5 | 5.8 | CN(Cc1n[nH]c(O)n1)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL209627 | 77597 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 528 | 8 | 2 | 5 | 5.8 | CN(Cc1n[nH]c(O)n1)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
46884433 | 7841 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 581 | 5 | 0 | 2 | 7.9 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090286 | 7841 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 581 | 5 | 0 | 2 | 7.9 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
57565074 | 87794 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 445 | 5 | 1 | 2 | 6.3 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNCCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347696 | 87794 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 445 | 5 | 1 | 2 | 6.3 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNCCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2112240 | 207483 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm960281e | ||||
44358495 | 115648 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 555 | 7 | 0 | 3 | 6.4 | CN(CC(c1ccccc1)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL335788 | 115648 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 555 | 7 | 0 | 3 | 6.4 | CN(CC(c1ccccc1)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
10722491 | 119530 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 615 | 12 | 2 | 5 | 5.4 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)c1ccccc1 | 10.1021/jm950616c | ||
CHEMBL350366 | 119530 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 615 | 12 | 2 | 5 | 5.4 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)c1ccccc1 | 10.1021/jm950616c | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL439019 | 212070 | 0 | None | 3 | 3 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
44294519 | 103034 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 610 | 6 | 1 | 4 | 7.2 | CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCC(=O)O3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL3085126 | 103034 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 610 | 6 | 1 | 4 | 7.2 | CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCC(=O)O3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
44407467 | 73615 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 410 | 5 | 2 | 3 | 5.1 | FC(F)(F)Oc1ccc(Cl)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL202141 | 73615 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 410 | 5 | 2 | 3 | 5.1 | FC(F)(F)Oc1ccc(Cl)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 | 10.1016/j.bmcl.2005.11.026 | ||
44415471 | 139030 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 474 | 7 | 1 | 3 | 5.0 | CN(CC(N)=O)[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL379707 | 139030 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 474 | 7 | 1 | 3 | 5.0 | CN(CC(N)=O)[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
46830287 | 7908 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 580 | 5 | 0 | 3 | 6.4 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090648 | 7908 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 580 | 5 | 0 | 3 | 6.4 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
46881729 | 7857 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1090421 | 7857 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
24752568 | 8824 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1097693 | 8824 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 490 | 4 | 1 | 3 | 5.0 | C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1651026 | 207083 | 19 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O | 10.1016/j.bmc.2010.07.034 | ||||
44358727 | 26631 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 555 | 7 | 0 | 3 | 6.4 | CN(CC(c1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL136323 | 26631 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 555 | 7 | 0 | 3 | 6.4 | CN(CC(c1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
44359071 | 165120 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 491 | 8 | 3 | 3 | 5.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc(F)ccc1F)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL424480 | 165120 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 491 | 8 | 3 | 3 | 5.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc(F)ccc1F)c1ccccc1 | 10.1021/jm00022a010 | ||
44177670 | 60933 | 0 | None | -1 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1151 | 27 | 10 | 10 | 5.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766206 | 60933 | 0 | None | -1 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1151 | 27 | 10 | 10 | 5.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
44334108 | 4581 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 504 | 6 | 0 | 2 | 7.6 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL103085 | 4581 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 504 | 6 | 0 | 2 | 7.6 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
135767968 | 45114 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 386 | 8 | 2 | 5 | 3.9 | Cc1cc(Cl)cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)c1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL152716 | 45114 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 386 | 8 | 2 | 5 | 3.9 | Cc1cc(Cl)cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)c1 | 10.1016/s0960-894x(97)10163-9 | ||
10457416 | 14717 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 470 | 7 | 2 | 2 | 5.5 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL120781 | 14717 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 470 | 7 | 2 | 2 | 5.5 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
490428 | 119071 | 6 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
CHEMBL346154 | 119071 | 6 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
44299273 | 193146 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 402 | 10 | 2 | 3 | 4.1 | Cc1cc(C)cc(COCC(NCC(N)=O)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL53901 | 193146 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 402 | 10 | 2 | 3 | 4.1 | Cc1cc(C)cc(COCC(NCC(N)=O)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
24782911 | 121575 | 0 | None | - | 0 | Mongolian jird | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 443 | 6 | 1 | 2 | 6.4 | Fc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596476 | 121575 | 0 | None | - | 0 | Mongolian jird | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 443 | 6 | 1 | 2 | 6.4 | Fc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
16663280 | 97512 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 475 | 4 | 0 | 2 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL272649 | 97512 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 475 | 4 | 0 | 2 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
16663280 | 97512 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 475 | 4 | 0 | 2 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL272649 | 97512 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 475 | 4 | 0 | 2 | 6.1 | C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
10744602 | 56087 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 523 | 10 | 2 | 4 | 4.1 | CC(=O)N(Cc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL163133 | 56087 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 523 | 10 | 2 | 4 | 4.1 | CC(=O)N(Cc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
44274277 | 80663 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 551 | 7 | 1 | 4 | 6.8 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-n3cccc3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL21548 | 80663 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 551 | 7 | 1 | 4 | 6.8 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-n3cccc3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
56681950 | 66132 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 451 | 7 | 0 | 4 | 5.2 | COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817887 | 66132 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 451 | 7 | 0 | 4 | 5.2 | COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852130 | 66132 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 451 | 7 | 0 | 4 | 5.2 | COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
44415484 | 168372 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.5 | N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL438789 | 168372 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.5 | N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
46884472 | 7913 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 580 | 5 | 0 | 3 | 6.4 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090653 | 7913 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 580 | 5 | 0 | 3 | 6.4 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
52947646 | 17063 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256588 | 17063 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 620 | 7 | 1 | 3 | 7.5 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
52948868 | 17066 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 559 | 5 | 1 | 3 | 6.5 | CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1256591 | 17066 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 559 | 5 | 1 | 3 | 6.5 | CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 | 10.1016/j.bmcl.2010.07.058 | ||
21994340 | 27812 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 623 | 7 | 0 | 3 | 7.7 | CN(CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL137255 | 27812 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 623 | 7 | 0 | 3 | 7.7 | CN(CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
11800372 | 117763 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 531 | 3 | 0 | 4 | 6.1 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
CHEMBL340931 | 117763 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 531 | 3 | 0 | 4 | 6.1 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
CHEMBL2370874 | 208194 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O | 10.1016/S0960-894X(01)80229-8 | ||||
44359094 | 33378 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 511 | 8 | 3 | 4 | 6.5 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2s1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL142121 | 33378 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 511 | 8 | 3 | 4 | 6.5 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2s1)c1ccccc1 | 10.1021/jm00022a010 | ||
9927183 | 193932 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 322 | 5 | 2 | 3 | 3.7 | COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 | 10.1021/jm9700171 | ||
CHEMBL55591 | 193932 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 322 | 5 | 2 | 3 | 3.7 | COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 | 10.1021/jm9700171 | ||
136180337 | 121005 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 460 | 8 | 3 | 5 | 4.6 | Oc1n[nH]c(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL358437 | 121005 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 460 | 8 | 3 | 5 | 4.6 | Oc1n[nH]c(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 | 10.1016/s0960-894x(97)10163-9 | ||
10834119 | 35403 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 351 | 5 | 1 | 2 | 5.1 | Cc1cc(COCC2(c3ccccc3)CCNCC2)cc(C(C)(C)C)c1 | 10.1021/jm980376b | ||
CHEMBL143974 | 35403 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 351 | 5 | 1 | 2 | 5.1 | Cc1cc(COCC2(c3ccccc3)CCNCC2)cc(C(C)(C)C)c1 | 10.1021/jm980376b | ||
CHEMBL405422 | 210814 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)SC)C(N)=O | 10.1021/jm00037a009 | ||||
44294224 | 103032 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 526 | 5 | 1 | 2 | 7.3 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCCCC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL3085124 | 103032 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 526 | 5 | 1 | 2 | 7.3 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCCCC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
9887525 | 189233 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
CHEMBL51648 | 189233 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
44415392 | 140890 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 513 | 7 | 2 | 4 | 6.1 | CN(Cc1c[nH]c(O)n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL384102 | 140890 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 513 | 7 | 2 | 4 | 6.1 | CN(Cc1c[nH]c(O)n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
24889113 | 7866 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 571 | 5 | 0 | 4 | 6.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090450 | 7866 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 571 | 5 | 0 | 4 | 6.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1204418 | 7866 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 571 | 5 | 0 | 4 | 6.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44358467 | 167678 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 571 | 8 | 1 | 4 | 6.1 | COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL433683 | 167678 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 571 | 8 | 1 | 4 | 6.1 | COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44328394 | 205966 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 438 | 7 | 1 | 3 | 5.3 | COc1ccccc1CNC1C2C3CCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL95561 | 205966 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 438 | 7 | 1 | 3 | 5.3 | COc1ccccc1CNC1C2C3CCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
44319084 | 13585 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 723 | 10 | 0 | 8 | 5.4 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL1194867 | 13585 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 723 | 10 | 0 | 8 | 5.4 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL553451 | 13585 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 723 | 10 | 0 | 8 | 5.4 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
44319321 | 13592 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 5.1 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL1194933 | 13592 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 5.1 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL553554 | 13592 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 5.1 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00006a011 | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00006a011 | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00006a011 | ||
CHEMBL405209 | 210802 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O | 10.1021/jm00037a009 | ||||
22293565 | 79217 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 607 | 6 | 0 | 3 | 8.7 | O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2115004 | 79217 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 607 | 6 | 0 | 3 | 8.7 | O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
46881682 | 8013 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1091469 | 8013 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
11654898 | 87802 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 6.0 | FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347852 | 87802 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 6.0 | FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
10369341 | 5677 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 518 | 4 | 1 | 3 | 6.5 | Cc1ccccc1-c1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 | 10.1021/jm00016a014 | ||
CHEMBL107848 | 5677 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 518 | 4 | 1 | 3 | 6.5 | Cc1ccccc1-c1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 | 10.1021/jm00016a014 | ||
9980171 | 9146 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 431 | 5 | 0 | 5 | 4.0 | COc1ccccc1CN(C)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL110679 | 9146 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 431 | 5 | 0 | 5 | 4.0 | COc1ccccc1CN(C)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C | 10.1021/jm00016a014 | ||
10506929 | 56285 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 | 10.1021/jm950616c | ||
CHEMBL164175 | 56285 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 | 10.1021/jm950616c | ||
18407045 | 81705 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 521 | 6 | 1 | 4 | 6.1 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2nc(Cl)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL21662 | 81705 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 521 | 6 | 1 | 4 | 6.1 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2nc(Cl)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL263852 | 208848 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)C)C(N)=O | 10.1021/jm00037a009 | ||||
23025481 | 64309 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 430 | 7 | 0 | 5 | 4.8 | COc1ccc([N+](=O)[O-])cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817893 | 64309 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 430 | 7 | 0 | 5 | 4.8 | COc1ccc([N+](=O)[O-])cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
57400460 | 70607 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 444 | 4 | 1 | 2 | 5.1 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951616 | 70607 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 444 | 4 | 1 | 2 | 5.1 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.11.048 | ||
57398780 | 70608 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 486 | 4 | 0 | 2 | 5.3 | CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951618 | 70608 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 486 | 4 | 0 | 2 | 5.3 | CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.11.048 | ||
46881779 | 8365 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1093750 | 8365 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 505 | 4 | 1 | 3 | 5.5 | C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
11561036 | 87803 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 6.0 | FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347853 | 87803 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 6.0 | FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
11539564 | 87804 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 445 | 5 | 0 | 2 | 6.3 | CN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347854 | 87804 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 445 | 5 | 0 | 2 | 6.3 | CN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL389651 | 210682 | 0 | None | 6 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
10369844 | 98879 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 534 | 7 | 2 | 3 | 6.3 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1021/jm00035a006 | ||
CHEMBL282290 | 98879 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 534 | 7 | 2 | 3 | 6.3 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1021/jm00035a006 | ||
24800578 | 86995 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 419 | 6 | 1 | 4 | 4.5 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(N2CCCC2)c1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333623 | 86995 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 419 | 6 | 1 | 4 | 4.5 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(N2CCCC2)c1 | 10.1016/j.bmcl.2012.11.094 | ||
44307417 | 201384 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 488 | 8 | 1 | 3 | 5.7 | NC(=O)CCCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL63762 | 201384 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 488 | 8 | 1 | 3 | 5.7 | NC(=O)CCCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
57397020 | 70612 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 583 | 5 | 1 | 3 | 5.2 | CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951622 | 70612 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 583 | 5 | 1 | 3 | 5.2 | CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 | 10.1016/j.bmc.2011.11.048 | ||
44456847 | 97003 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 566 | 6 | 0 | 2 | 7.4 | C[C@@H](O[C@H]1CN2C(=O)N(Cc3ccccc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL270114 | 97003 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 566 | 6 | 0 | 2 | 7.4 | C[C@@H](O[C@H]1CN2C(=O)N(Cc3ccccc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
44415436 | 79549 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.8 | NC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL212644 | 79549 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.8 | NC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
44415530 | 79721 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 460 | 5 | 2 | 2 | 5.5 | CNC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL213316 | 79721 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 460 | 5 | 2 | 2 | 5.5 | CNC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
44415448 | 140908 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 474 | 7 | 1 | 3 | 5.0 | CN(CC(N)=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL384157 | 140908 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 474 | 7 | 1 | 3 | 5.0 | CN(CC(N)=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
46881729 | 7857 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1090421 | 7857 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
10414293 | 37220 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
CHEMBL145535 | 37220 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
71449143 | 79110 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 611 | 5 | 2 | 3 | 6.7 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL2113740 | 79110 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 611 | 5 | 2 | 3 | 6.7 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 | 10.1016/s0960-894x(02)00382-7 | ||
10603019 | 5173 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 564 | 11 | 1 | 5 | 4.7 | COc1ccccc1CN(CC(Cc1cccc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL106334 | 5173 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 564 | 11 | 1 | 5 | 4.7 | COc1ccccc1CN(CC(Cc1cccc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
10369653 | 96352 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 528 | 7 | 0 | 4 | 7.2 | Cc1nc(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)cs1 | 10.1021/jm980376b | ||
CHEMBL264997 | 96352 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 528 | 7 | 0 | 4 | 7.2 | Cc1nc(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)cs1 | 10.1021/jm980376b | ||
10624372 | 202013 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 475 | 6 | 0 | 4 | 5.6 | COC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL67612 | 202013 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 475 | 6 | 0 | 4 | 5.6 | COC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
44318640 | 204141 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 399 | 4 | 1 | 4 | 4.6 | COc1ccc(C(C)C)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL83716 | 204141 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 399 | 4 | 1 | 4 | 4.6 | COc1ccc(C(C)C)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
44410155 | 138759 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 569 | 6 | 1 | 4 | 6.5 | O=S(=O)(c1ccccc1)C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
CHEMBL379152 | 138759 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 569 | 6 | 1 | 4 | 6.5 | O=S(=O)(c1ccccc1)C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
24782912 | 121573 | 0 | None | - | 0 | Mongolian jird | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 6.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596474 | 121573 | 0 | None | - | 0 | Mongolian jird | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 6.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
44433800 | 146256 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL392463 | 146256 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
21994327 | 26723 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 591 | 7 | 1 | 3 | 7.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL136411 | 26723 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 591 | 7 | 1 | 3 | 7.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
10815815 | 119556 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 519 | 11 | 2 | 5 | 3.3 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N(C)C)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL350582 | 119556 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 519 | 11 | 2 | 5 | 3.3 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N(C)C)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL387670 | 210664 | 0 | None | 109 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061369n | ||||
44333964 | 5073 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 511 | 6 | 0 | 3 | 6.8 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CCCCC3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL105763 | 5073 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 511 | 6 | 0 | 3 | 6.8 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CCCCC3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
10837611 | 32025 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 459 | 6 | 0 | 2 | 6.7 | CC(C)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL140982 | 32025 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 459 | 6 | 0 | 2 | 6.7 | CC(C)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
10669293 | 33225 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 373 | 5 | 1 | 2 | 4.6 | Cc1cc(Br)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
CHEMBL141994 | 33225 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 373 | 5 | 1 | 2 | 4.6 | Cc1cc(Br)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
44274362 | 168625 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 487 | 6 | 1 | 4 | 5.4 | Cn1c(-c2ccccn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL440649 | 168625 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 487 | 6 | 1 | 4 | 5.4 | Cn1c(-c2ccccn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL2372518 | 208522 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O | 10.1021/jm00037a009 | ||||
2102 | 1166 | 17 | None | 2 | 2 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(01)00044-0 | ||
5311057 | 1166 | 17 | None | 2 | 2 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(01)00044-0 | ||
CHEMBL441225 | 1166 | 17 | None | 2 | 2 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/s0960-894x(01)00044-0 | ||
44358767 | 26903 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 593 | 7 | 1 | 3 | 6.9 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL136559 | 26903 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 593 | 7 | 1 | 3 | 6.9 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44358741 | 30866 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 491 | 7 | 0 | 5 | 4.7 | Cc1cc(C)cc(CC(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)c1 | 10.1021/jm000986n | ||
CHEMBL139967 | 30866 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 491 | 7 | 0 | 5 | 4.7 | Cc1cc(C)cc(CC(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)c1 | 10.1021/jm000986n | ||
CHEMBL2371977 | 208426 | 0 | None | 17 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
11705830 | 105334 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 489 | 9 | 0 | 3 | 6.3 | COCCN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126973 | 105334 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 489 | 9 | 0 | 3 | 6.3 | COCCN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
10318976 | 205560 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 403 | 5 | 1 | 2 | 5.5 | FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80585-0 | ||
CHEMBL93216 | 205560 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 403 | 5 | 1 | 2 | 5.5 | FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80585-0 | ||
44326306 | 111844 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 319 | 5 | 1 | 2 | 4.0 | Cc1cc(Br)cc(COC[C@@H](N)c2ccccc2)c1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL329325 | 111844 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 319 | 5 | 1 | 2 | 4.0 | Cc1cc(Br)cc(COC[C@@H](N)c2ccccc2)c1 | 10.1016/0960-894X(95)00476-A | ||
44321442 | 204530 | 1 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00092a009 | ||
CHEMBL86806 | 204530 | 1 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00092a009 | ||
24800743 | 86989 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 411 | 6 | 1 | 4 | 4.1 | CN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCNCC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333617 | 86989 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 411 | 6 | 1 | 4 | 4.1 | CN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCNCC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
44433802 | 146258 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL392464 | 146258 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
44335376 | 4477 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 717 | 7 | 2 | 4 | 6.3 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 | 10.1016/s0960-894x(01)00631-x | ||
CHEMBL102376 | 4477 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 717 | 7 | 2 | 4 | 6.3 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 | 10.1016/s0960-894x(01)00631-x | ||
44370369 | 48640 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 541 | 12 | 1 | 3 | 7.0 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL155976 | 48640 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 541 | 12 | 1 | 3 | 7.0 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 | 10.1016/0960-894X(95)00080-D | ||
44288951 | 100016 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 515 | 5 | 2 | 2 | 5.6 | CC(C)NC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL290926 | 100016 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 515 | 5 | 2 | 2 | 5.6 | CC(C)NC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
19797419 | 164708 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL423019 | 164708 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
44380708 | 57270 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 356 | 5 | 1 | 3 | 4.3 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL166610 | 57270 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 356 | 5 | 1 | 3 | 4.3 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 | 10.1016/S0960-894X(01)80859-3 | ||
9329 | 3684 | 3 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 | 10.1021/jm990220r | ||
9894349 | 3684 | 3 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 | 10.1021/jm990220r | ||
CHEMBL339486 | 3684 | 3 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 | 10.1021/jm990220r | ||
44277726 | 98653 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm9700171 | ||
CHEMBL280849 | 98653 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm9700171 | ||
CHEMBL413827 | 211340 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O | 10.1021/jm070577s | ||||
44177145 | 194055 | 0 | None | -6 | 3 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1191 | 27 | 10 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL557188 | 194055 | 0 | None | -6 | 3 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1191 | 27 | 10 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
44410321 | 140713 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 443 | 4 | 1 | 2 | 6.6 | C[C@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
CHEMBL382988 | 140713 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 443 | 4 | 1 | 2 | 6.6 | C[C@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
58993596 | 121551 | 0 | None | - | 0 | Mongolian jird | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 417 | 6 | 2 | 5 | 3.7 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nnn[nH]2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596452 | 121551 | 0 | None | - | 0 | Mongolian jird | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 417 | 6 | 2 | 5 | 3.7 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nnn[nH]2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
44324706 | 205535 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 696 | 16 | 0 | 4 | 7.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C)cc(C)c2)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL93038 | 205535 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 696 | 16 | 0 | 4 | 7.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C)cc(C)c2)C1 | 10.1016/S0960-894X(01)80747-2 | ||
44348756 | 15392 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 429 | 0 | 1 | 4 | 5.6 | C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@]2(C)O)nc1ccccc14 | 10.1021/jm00080a025 | ||
CHEMBL122020 | 15392 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 429 | 0 | 1 | 4 | 5.6 | C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@]2(C)O)nc1ccccc14 | 10.1021/jm00080a025 | ||
10627355 | 119505 | 0 | None | - | 0 | Mouse | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 596 | 13 | 2 | 6 | 3.6 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C | 10.1021/jm950616c | ||
CHEMBL350151 | 119505 | 0 | None | - | 0 | Mouse | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 596 | 13 | 2 | 6 | 3.6 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C | 10.1021/jm950616c | ||
44297520 | 194409 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 443 | 6 | 1 | 5 | 1.9 | CS(=O)(=O)N1CC2(CCN(C(=O)C(N)COCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL56069 | 194409 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 443 | 6 | 1 | 5 | 1.9 | CS(=O)(=O)N1CC2(CCN(C(=O)C(N)COCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44294355 | 11138 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 453 | 5 | 1 | 5 | 3.7 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
49824390 | 11138 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 453 | 5 | 1 | 5 | 3.7 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1178897 | 11138 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 453 | 5 | 1 | 5 | 3.7 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL48454 | 11138 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 453 | 5 | 1 | 5 | 3.7 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
12225557 | 120664 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL357717 | 120664 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81197-5 | ||
156500036 | 185862 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 428 | 5 | 3 | 4 | 3.9 | Cc1c(C2(c3ccc(C(F)(F)F)c(C#N)c3)CC2)c[nH]c1C(=O)NC(C)c1nc[nH]n1 | 10.1021/acs.jmedchem.1c00173 | ||
CHEMBL4876457 | 185862 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 428 | 5 | 3 | 4 | 3.9 | Cc1c(C2(c3ccc(C(F)(F)F)c(C#N)c3)CC2)c[nH]c1C(=O)NC(C)c1nc[nH]n1 | 10.1021/acs.jmedchem.1c00173 | ||
136046099 | 11050 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 430 | 4 | 0 | 2 | 6.0 | CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
49824391 | 11050 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 430 | 4 | 0 | 2 | 6.0 | CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
CHEMBL1178358 | 11050 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 430 | 4 | 0 | 2 | 6.0 | CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
CHEMBL23181 | 11050 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 430 | 4 | 0 | 2 | 6.0 | CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
10456618 | 131713 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 454 | 4 | 1 | 2 | 5.3 | O=C1CC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
CHEMBL369692 | 131713 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 454 | 4 | 1 | 2 | 5.3 | O=C1CC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
10698161 | 5124 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 562 | 10 | 2 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL106083 | 5124 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 562 | 10 | 2 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
11363490 | 93622 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 4 | 1 | 2 | 6.9 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc2ccccc2c1-c1ccccc1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL24894 | 93622 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 4 | 1 | 2 | 6.9 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc2ccccc2c1-c1ccccc1 | 10.1016/j.bmc.2011.02.031 | ||
44359054 | 31610 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 555 | 8 | 3 | 3 | 7.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1c2ccccc2cc2ccccc12)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL140659 | 31610 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 555 | 8 | 3 | 3 | 7.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1c2ccccc2cc2ccccc12)c1ccccc1 | 10.1021/jm00022a010 | ||
10556941 | 98757 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 738 | 21 | 2 | 7 | 7.7 | CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccc(F)cc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 | 10.1021/jm9800346 | ||
CHEMBL281530 | 98757 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 738 | 21 | 2 | 7 | 7.7 | CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccc(F)cc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 | 10.1021/jm9800346 | ||
44333561 | 4602 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 488 | 6 | 1 | 4 | 5.7 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C#N)cc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL103221 | 4602 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 488 | 6 | 1 | 4 | 5.7 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C#N)cc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
21753665 | 197996 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 387 | 8 | 1 | 2 | 5.2 | CC(=O)NC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL59310 | 197996 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 387 | 8 | 1 | 2 | 5.2 | CC(=O)NC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
10811257 | 101357 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
CHEMBL300303 | 101357 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
16755279 | 174521 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 547 | 4 | 0 | 5 | 6.4 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL456875 | 174521 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 547 | 4 | 0 | 5 | 6.4 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL413827 | 211340 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O | 10.1021/jm070577s | ||||
44277726 | 98653 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(00)80349-2 | ||
CHEMBL280849 | 98653 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(00)80349-2 | ||
10350454 | 106249 | 0 | None | 10 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 815 | 18 | 4 | 8 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144209 | 106249 | 0 | None | 10 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 815 | 18 | 4 | 8 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
44312951 | 102727 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 668 | 16 | 6 | 6 | 2.4 | CC(=O)NC(C(=O)NCCCC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O | 10.1021/jm00068a003 | ||
CHEMBL308363 | 102727 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 668 | 16 | 6 | 6 | 2.4 | CC(=O)NC(C(=O)NCCCC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O | 10.1021/jm00068a003 | ||
9831641 | 79287 | 5 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 672 | 8 | 0 | 7 | 6.0 | COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(00)00324-3 | ||
CHEMBL2115415 | 79287 | 5 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 672 | 8 | 0 | 7 | 6.0 | COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(00)00324-3 | ||
10071124 | 98337 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 426 | 7 | 2 | 3 | 4.9 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm9700171 | ||
CHEMBL278351 | 98337 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 426 | 7 | 2 | 3 | 4.9 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm9700171 | ||
10506376 | 55567 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 529 | 10 | 2 | 4 | 4.4 | CC(=O)N(CC1CCCCC1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL162330 | 55567 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 529 | 10 | 2 | 4 | 4.4 | CC(=O)N(CC1CCCCC1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
44304144 | 13325 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 597 | 15 | 4 | 8 | 1.8 | NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL1192961 | 13325 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 597 | 15 | 4 | 8 | 1.8 | NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL544284 | 13325 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 597 | 15 | 4 | 8 | 1.8 | NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
44288772 | 155065 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccncc3)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL40455 | 155065 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 4.7 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccncc3)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
44358416 | 27103 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 631 | 10 | 1 | 6 | 6.1 | COc1ccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC | 10.1021/jm000986n | ||
CHEMBL136735 | 27103 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 631 | 10 | 1 | 6 | 6.1 | COc1ccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC | 10.1021/jm000986n | ||
44383969 | 128524 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.5 | FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00006a012 | ||
CHEMBL367034 | 128524 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.5 | FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00006a012 | ||
10412224 | 86295 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 466 | 7 | 2 | 3 | 5.3 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(C(F)(F)F)cc1)c1ccccc1 | 10.1021/jm00035a006 | ||
CHEMBL23184 | 86295 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 466 | 7 | 2 | 3 | 5.3 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(C(F)(F)F)cc1)c1ccccc1 | 10.1021/jm00035a006 | ||
44324845 | 168727 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 634 | 16 | 1 | 4 | 7.0 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C(C)C)C(C)C)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL441458 | 168727 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 634 | 16 | 1 | 4 | 7.0 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C(C)C)C(C)C)C1 | 10.1016/S0960-894X(01)80747-2 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00006a012 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00006a012 | ||
10071124 | 98337 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 426 | 7 | 2 | 3 | 4.9 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm00006a012 | ||
CHEMBL278351 | 98337 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 426 | 7 | 2 | 3 | 4.9 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm00006a012 | ||
10004190 | 129565 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 456 | 4 | 1 | 3 | 5.3 | O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
CHEMBL367711 | 129565 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 456 | 4 | 1 | 3 | 5.3 | O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
10071124 | 98337 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 426 | 7 | 2 | 3 | 4.9 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm00035a006 | ||
CHEMBL278351 | 98337 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 426 | 7 | 2 | 3 | 4.9 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm00035a006 | ||
44294481 | 103033 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 486 | 5 | 1 | 2 | 6.3 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N(C)C)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
CHEMBL3085125 | 103033 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 486 | 5 | 1 | 2 | 6.3 | CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N(C)C)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00250-0 | ||
24799711 | 87004 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 6 | 0 | 4 | 4.4 | COc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333632 | 87004 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 6 | 0 | 4 | 4.4 | COc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
42639650 | 187612 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 569 | 5 | 0 | 3 | 8.1 | C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
CHEMBL499004 | 187612 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 569 | 5 | 0 | 3 | 8.1 | C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
44358552 | 118680 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 539 | 8 | 0 | 5 | 5.7 | CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm000986n | ||
CHEMBL343150 | 118680 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 539 | 8 | 0 | 5 | 5.7 | CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm000986n | ||
44270411 | 11878 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 453 | 9 | 1 | 2 | 5.8 | C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
CHEMBL1183074 | 11878 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 453 | 9 | 1 | 2 | 5.8 | C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
CHEMBL278487 | 11878 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 453 | 9 | 1 | 2 | 5.8 | C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
44359096 | 28918 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 8 | 3 | 3 | 5.6 | Cc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/jm00022a010 | ||
CHEMBL138146 | 28918 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 8 | 3 | 3 | 5.6 | Cc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/jm00022a010 | ||
46227363 | 197984 | 0 | None | -28 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL592969 | 197984 | 0 | None | -28 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
44212281 | 130094 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 609 | 9 | 1 | 5 | 5.7 | COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL368159 | 130094 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 609 | 9 | 1 | 5 | 5.7 | COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/0960-894X(96)00148-5 | ||
44346420 | 14190 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 473 | 5 | 0 | 3 | 4.8 | COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] | 10.1021/jm9700171 | ||
CHEMBL119990 | 14190 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 473 | 5 | 0 | 3 | 4.8 | COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] | 10.1021/jm9700171 | ||
10393324 | 120296 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 574 | 5 | 2 | 3 | 6.8 | O=C1C(Cc2c[nH]c3ccccc23)N(C(=O)Nc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
CHEMBL355643 | 120296 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 574 | 5 | 2 | 3 | 6.8 | O=C1C(Cc2c[nH]c3ccccc23)N(C(=O)Nc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
56675185 | 66114 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 459 | 5 | 0 | 2 | 6.2 | O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817834 | 66114 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 459 | 5 | 0 | 2 | 6.2 | O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852026 | 66114 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 459 | 5 | 0 | 2 | 6.2 | O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
68870199 | 124274 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 535 | 5 | 0 | 3 | 5.8 | CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL3642171 | 124274 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 535 | 5 | 0 | 3 | 5.8 | CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
44348605 | 112598 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 415 | 0 | 1 | 4 | 5.2 | C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@@H]2O)nc1ccccc14 | 10.1021/jm00080a025 | ||
CHEMBL331346 | 112598 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 415 | 0 | 1 | 4 | 5.2 | C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@@H]2O)nc1ccccc14 | 10.1021/jm00080a025 | ||
44288892 | 101035 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 5.3 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccccc3)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL297970 | 101035 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 5.3 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccccc3)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
44289168 | 168515 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL43977 | 168515 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL2112246 | 207489 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm000316h | ||||
71461705 | 79208 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 672 | 8 | 0 | 7 | 6.0 | COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(00)00324-3 | ||
CHEMBL2114963 | 79208 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 672 | 8 | 0 | 7 | 6.0 | COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(00)00324-3 | ||
9914897 | 178480 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 528 | 15 | 4 | 4 | 5.0 | CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 | 10.1016/0960-894X(95)00313-I | ||
CHEMBL47146 | 178480 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 528 | 15 | 4 | 4 | 5.0 | CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 | 10.1016/0960-894X(95)00313-I | ||
21994362 | 29514 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 465 | 9 | 1 | 5 | 4.1 | COc1ccc(CC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm000986n | ||
CHEMBL138666 | 29514 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 465 | 9 | 1 | 5 | 4.1 | COc1ccc(CC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 | 10.1021/jm000986n | ||
9914897 | 178480 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 528 | 15 | 4 | 4 | 5.0 | CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 | 10.1021/jm950892r | ||
CHEMBL47146 | 178480 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 528 | 15 | 4 | 4 | 5.0 | CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 | 10.1021/jm950892r | ||
44212688 | 154507 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 375 | 8 | 1 | 3 | 4.5 | COc1cc(CNC(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL40164 | 154507 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 375 | 8 | 1 | 3 | 4.5 | COc1cc(CNC(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 | 10.1016/S0960-894X(96)00280-6 | ||
44212684 | 162429 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 389 | 8 | 0 | 3 | 4.9 | COc1cc(CN(C)C(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL417519 | 162429 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 389 | 8 | 0 | 3 | 4.9 | COc1cc(CN(C)C(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 | 10.1016/S0960-894X(96)00280-6 | ||
44287557 | 168131 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 383 | 6 | 1 | 1 | 5.8 | O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(Cl)cc(Cl)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL436698 | 168131 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 383 | 6 | 1 | 1 | 5.8 | O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(Cl)cc(Cl)c1 | 10.1016/S0960-894X(96)00280-6 | ||
15037919 | 119122 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 396 | 6 | 1 | 2 | 5.4 | Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL346633 | 119122 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 396 | 6 | 1 | 2 | 5.4 | Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
44307409 | 101787 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 353 | 7 | 2 | 4 | 2.5 | COc1ccccc1CN[C@H]1CCCN(CC(N)=O)[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL303181 | 101787 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 353 | 7 | 2 | 4 | 2.5 | COc1ccccc1CN[C@H]1CCCN(CC(N)=O)[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
10458783 | 98164 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 504 | 5 | 2 | 3 | 6.4 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CO)nc2ccccc2c1-c1ccccc1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL277004 | 98164 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 504 | 5 | 2 | 3 | 6.4 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CO)nc2ccccc2c1-c1ccccc1 | 10.1016/j.bmc.2011.02.031 | ||
44312219 | 101911 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 506 | 6 | 3 | 2 | 5.1 | O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL303868 | 101911 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 506 | 6 | 3 | 2 | 5.1 | O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00395-3 | ||
15639130 | 113016 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 422 | 6 | 1 | 2 | 5.7 | c1ccc(CN[C@H]2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
CHEMBL332106 | 113016 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 422 | 6 | 1 | 2 | 5.7 | c1ccc(CN[C@H]2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
44346524 | 113022 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 360 | 4 | 1 | 2 | 4.9 | Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 | 10.1021/jm9700171 | ||
CHEMBL332140 | 113022 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 360 | 4 | 1 | 2 | 4.9 | Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 | 10.1021/jm9700171 | ||
10484232 | 193758 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 635 | 9 | 1 | 5 | 5.7 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL55229 | 193758 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 635 | 9 | 1 | 5 | 5.7 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
22859118 | 167650 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 445 | 8 | 2 | 5 | 4.3 | FC(F)(F)c1cc(COC[C@@H](NCc2nn[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL433539 | 167650 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 445 | 8 | 2 | 5 | 4.3 | FC(F)(F)c1cc(COC[C@@H](NCc2nn[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(97)10163-9 | ||
44346420 | 14190 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 473 | 5 | 0 | 3 | 4.8 | COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] | 10.1016/S0960-894X(01)80177-3 | ||
CHEMBL119990 | 14190 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 473 | 5 | 0 | 3 | 4.8 | COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] | 10.1016/S0960-894X(01)80177-3 | ||
58993475 | 121561 | 0 | None | - | 0 | Mongolian jird | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 443 | 6 | 1 | 2 | 6.4 | Fc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596462 | 121561 | 0 | None | - | 0 | Mongolian jird | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 443 | 6 | 1 | 2 | 6.4 | Fc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
46884434 | 7843 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 593 | 6 | 1 | 3 | 7.3 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090288 | 7843 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 593 | 6 | 1 | 3 | 7.3 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44306252 | 101739 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 602 | 8 | 2 | 5 | 4.6 | Cc1ccc2cc(C[C@@H](NC(=O)C3C[C@@H](O)CN3C(=O)c3cn(C)c4ccccc34)C(=O)N(C)Cc3ccccc3)ccc2c1 | 10.1021/jm00039a022 | ||
CHEMBL302892 | 101739 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 602 | 8 | 2 | 5 | 4.6 | Cc1ccc2cc(C[C@@H](NC(=O)C3C[C@@H](O)CN3C(=O)c3cn(C)c4ccccc34)C(=O)N(C)Cc3ccccc3)ccc2c1 | 10.1021/jm00039a022 | ||
44306226 | 101772 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 496 | 9 | 3 | 3 | 4.1 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(C)(C)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL303116 | 101772 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 496 | 9 | 3 | 3 | 4.1 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(C)(C)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
10005824 | 5826 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 491 | 5 | 0 | 3 | 7.0 | Cn1c(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)c2ccccc2c1=O | 10.1021/jm00016a014 | ||
CHEMBL107959 | 5826 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 491 | 5 | 0 | 3 | 7.0 | Cn1c(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)c2ccccc2c1=O | 10.1021/jm00016a014 | ||
9868622 | 6120 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 455 | 5 | 1 | 4 | 5.5 | COc1ccccc1CN(C)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL108126 | 6120 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 455 | 5 | 1 | 4 | 5.5 | COc1ccccc1CN(C)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C | 10.1021/jm00016a014 | ||
9888665 | 121467 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 425 | 7 | 0 | 2 | 6.3 | Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL359206 | 121467 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 425 | 7 | 0 | 2 | 6.3 | Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
44312256 | 202874 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 554 | 7 | 2 | 5 | 5.7 | CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL73097 | 202874 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 554 | 7 | 2 | 5 | 5.7 | CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
44312888 | 96288 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 626 | 14 | 6 | 6 | 1.4 | C[C@@H](O)C(NC(=O)CC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O | 10.1021/jm00068a003 | ||
CHEMBL264384 | 96288 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 626 | 14 | 6 | 6 | 1.4 | C[C@@H](O)C(NC(=O)CC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O | 10.1021/jm00068a003 | ||
44319340 | 204197 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 707 | 10 | 0 | 6 | 7.2 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL84055 | 204197 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 707 | 10 | 0 | 6 | 7.2 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
44319250 | 106524 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 589 | 10 | 1 | 6 | 4.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL315322 | 106524 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 589 | 10 | 1 | 6 | 4.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
158365 | 188137 | 4 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 664 | 5 | 4 | 6 | 3.1 | O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1([C@]34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 | 10.1021/np50111a008 | ||
CHEMBL504788 | 188137 | 4 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 664 | 5 | 4 | 6 | 3.1 | O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1([C@]34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 | 10.1021/np50111a008 | ||
44346524 | 113022 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 360 | 4 | 1 | 2 | 4.9 | Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL332140 | 113022 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 360 | 4 | 1 | 2 | 4.9 | Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 | 10.1016/S0960-894X(01)80859-3 | ||
44328407 | 106823 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 422 | 6 | 1 | 2 | 5.7 | c1ccc(CNC2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00044a002 | ||
CHEMBL317289 | 106823 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 422 | 6 | 1 | 2 | 5.7 | c1ccc(CNC2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00044a002 | ||
CHEMBL406812 | 210874 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O | 10.1021/jm00037a009 | ||||
44344209 | 114051 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 477 | 6 | 1 | 3 | 6.4 | Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@@H](C)c2ccccc2)c1 | 10.1016/S0960-894X(96)00623-3 | ||
CHEMBL333726 | 114051 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 477 | 6 | 1 | 3 | 6.4 | Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@@H](C)c2ccccc2)c1 | 10.1016/S0960-894X(96)00623-3 | ||
44375297 | 56498 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 475 | 7 | 3 | 5 | 4.6 | O=C(NC(c1ccccc1)c1ccccc1)[C@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] | 10.1016/s0960-894x(01)00044-0 | ||
CHEMBL164361 | 56498 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 475 | 7 | 3 | 5 | 4.6 | O=C(NC(c1ccccc1)c1ccccc1)[C@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] | 10.1016/s0960-894x(01)00044-0 | ||
19003143 | 202160 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 319 | 6 | 1 | 2 | 4.5 | Cc1cc(C)cc(COCC(N)Cc2ccc3ccccc3c2)c1 | 10.1016/S0960-894X(00)80063-3 | ||
CHEMBL68670 | 202160 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 319 | 6 | 1 | 2 | 4.5 | Cc1cc(C)cc(COCC(N)Cc2ccc3ccccc3c2)c1 | 10.1016/S0960-894X(00)80063-3 | ||
10448006 | 202199 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 308 | 6 | 2 | 2 | 3.9 | Cc1cc(C)cc(COCC(N)Cc2c[nH]c3ccccc23)c1 | 10.1016/S0960-894X(00)80063-3 | ||
CHEMBL68934 | 202199 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 308 | 6 | 2 | 2 | 3.9 | Cc1cc(C)cc(COCC(N)Cc2c[nH]c3ccccc23)c1 | 10.1016/S0960-894X(00)80063-3 | ||
44321047 | 204461 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 336 | 6 | 1 | 3 | 3.5 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL86378 | 204461 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 336 | 6 | 1 | 3 | 3.5 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 | 10.1021/jm9700171 | ||
44346550 | 14519 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 319 | 6 | 1 | 2 | 4.5 | Cc1cc(C)cc(COC[C@@H](N)Cc2ccc3ccccc3c2)c1 | 10.1021/jm9700171 | ||
CHEMBL120589 | 14519 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 319 | 6 | 1 | 2 | 4.5 | Cc1cc(C)cc(COC[C@@H](N)Cc2ccc3ccccc3c2)c1 | 10.1021/jm9700171 | ||
44346476 | 113627 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 308 | 6 | 2 | 2 | 3.9 | Cc1cc(C)cc(COC[C@@H](N)Cc2c[nH]c3ccccc23)c1 | 10.1021/jm9700171 | ||
CHEMBL332843 | 113627 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 308 | 6 | 2 | 2 | 3.9 | Cc1cc(C)cc(COC[C@@H](N)Cc2c[nH]c3ccccc23)c1 | 10.1021/jm9700171 | ||
44287210 | 99903 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 451 | 6 | 1 | 1 | 6.6 | O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL289728 | 99903 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 451 | 6 | 1 | 1 | 6.6 | O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
54582278 | 60825 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 472 | 5 | 1 | 2 | 6.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)ccnc1CCl | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765497 | 60825 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 472 | 5 | 1 | 2 | 6.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)ccnc1CCl | 10.1016/j.bmc.2011.02.031 | ||
16755278 | 189393 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 533 | 4 | 1 | 5 | 6.1 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL517102 | 189393 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 533 | 4 | 1 | 5 | 6.1 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL302668 | 209168 | 0 | None | - | 0 | Guinea pig | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | None | None | None | O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)OCc1ccccc1 | 10.1021/jm00089a011 | ||||
44297648 | 191980 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 600 | 9 | 2 | 5 | 4.6 | CS(=O)(=O)N1CC2(CCN(C(=O)C(CNCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL52139 | 191980 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 600 | 9 | 2 | 5 | 4.6 | CS(=O)(=O)N1CC2(CCN(C(=O)C(CNCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44318406 | 169138 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 395 | 2 | 1 | 3 | 4.4 | Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2C(F)(F)F)C3)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL443799 | 169138 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 395 | 2 | 1 | 3 | 4.4 | Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2C(F)(F)F)C3)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
24782915 | 121565 | 0 | None | - | 0 | Mongolian jird | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 439 | 6 | 1 | 2 | 6.5 | Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596466 | 121565 | 0 | None | - | 0 | Mongolian jird | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 439 | 6 | 1 | 2 | 6.5 | Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
44433795 | 88343 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 536 | 5 | 0 | 4 | 5.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cncnc2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL236304 | 88343 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 536 | 5 | 0 | 4 | 5.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cncnc2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
18709628 | 166255 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 515 | 12 | 2 | 5 | 4.3 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccccc1OC)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL42845 | 166255 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 515 | 12 | 2 | 5 | 4.3 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccccc1OC)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
9873546 | 77683 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 566 | 8 | 1 | 2 | 7.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 | 10.1021/jm060439n | ||
CHEMBL209899 | 77683 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 566 | 8 | 1 | 2 | 7.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 | 10.1021/jm060439n | ||
44348667 | 113829 | 1 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 439 | 0 | 1 | 4 | 5.2 | C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL124542 | 113829 | 1 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 439 | 0 | 1 | 4 | 5.2 | C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL333069 | 113829 | 1 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 439 | 0 | 1 | 4 | 5.2 | C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
44288926 | 101013 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 591 | 6 | 1 | 3 | 6.8 | O=C(c1cc(Br)cc(Br)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL297833 | 101013 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 591 | 6 | 1 | 3 | 6.8 | O=C(c1cc(Br)cc(Br)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
104943 | 55099 | 34 | None | - | 3 | Mouse | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
CHEMBL16192 | 55099 | 34 | None | - | 3 | Mouse | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
25129133 | 188300 | 0 | None | -1122 | 5 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL507340 | 188300 | 0 | None | -1122 | 5 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
44303794 | 100363 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 711 | 16 | 3 | 9 | 3.7 | CN(C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL293355 | 100363 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 711 | 16 | 3 | 9 | 3.7 | CN(C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
71699790 | 124263 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 549 | 4 | 0 | 3 | 5.4 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL3642160 | 124263 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 549 | 4 | 0 | 3 | 5.4 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
44381059 | 57529 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 356 | 5 | 1 | 3 | 4.3 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL167066 | 57529 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 356 | 5 | 1 | 3 | 4.3 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL2112246 | 207489 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm000316h | ||||
CHEMBL2372444 | 208500 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O | 10.1021/jm00037a009 | ||||
10478708 | 205839 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 445 | 8 | 1 | 1 | 6.1 | O=C(NCCc1ccccc1)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 | 10.1016/S0960-894X(01)80821-0 | ||
CHEMBL94883 | 205839 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 445 | 8 | 1 | 1 | 6.1 | O=C(NCCc1ccccc1)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 | 10.1016/S0960-894X(01)80821-0 | ||
21994346 | 30011 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 435 | 8 | 1 | 4 | 4.0 | COc1ccccc1C(CNC(=O)Cc1ccccc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL139071 | 30011 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 435 | 8 | 1 | 4 | 4.0 | COc1ccccc1C(CNC(=O)Cc1ccccc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
44312324 | 202978 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 534 | 7 | 2 | 2 | 5.8 | CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL73896 | 202978 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 534 | 7 | 2 | 2 | 5.8 | CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00395-3 | ||
15295988 | 60747 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 455 | 4 | 2 | 2 | 4.7 | O=C1CNC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
CHEMBL176471 | 60747 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 455 | 4 | 2 | 2 | 4.7 | O=C1CNC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
10477953 | 98478 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 432 | 7 | 2 | 3 | 4.9 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(Cl)cc1)c1ccccc1 | 10.1021/jm00035a006 | ||
CHEMBL279500 | 98478 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 432 | 7 | 2 | 3 | 4.9 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(Cl)cc1)c1ccccc1 | 10.1021/jm00035a006 | ||
19797451 | 36576 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
CHEMBL145008 | 36576 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
44307118 | 201321 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 474 | 4 | 1 | 3 | 4.5 | NC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL63257 | 201321 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 474 | 4 | 1 | 3 | 4.5 | NC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
24782656 | 121568 | 0 | None | - | 0 | Mongolian jird | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 6 | 2 | 3 | 5.8 | Nc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596469 | 121568 | 0 | None | - | 0 | Mongolian jird | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 6 | 2 | 3 | 5.8 | Nc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
44338639 | 5649 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 364 | 6 | 1 | 3 | 4.2 | Clc1cc(Cl)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL107831 | 5649 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 364 | 6 | 1 | 3 | 4.2 | Clc1cc(Cl)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
44338532 | 7549 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 324 | 6 | 1 | 3 | 3.5 | Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL108822 | 7549 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 324 | 6 | 1 | 3 | 3.5 | Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
44322735 | 105497 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 472 | 6 | 1 | 2 | 5.7 | Cc1cccc(CN(C(=O)CCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL313070 | 105497 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 472 | 6 | 1 | 2 | 5.7 | Cc1cccc(CN(C(=O)CCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 | 10.1016/s0960-894x(01)00727-2 | ||
44322728 | 204942 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 494 | 6 | 1 | 3 | 5.5 | O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL89425 | 204942 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 494 | 6 | 1 | 3 | 5.5 | O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
9801487 | 205270 | 0 | None | 5 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 5 | 1 | 3 | 4.8 | Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL91418 | 205270 | 0 | None | 5 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 5 | 1 | 3 | 4.8 | Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 | 10.1016/s0960-894x(01)00727-2 | ||
25129133 | 188300 | 0 | None | -1122 | 5 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800389v | ||
CHEMBL507340 | 188300 | 0 | None | -1122 | 5 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800389v | ||
44306034 | 102254 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 631 | 10 | 3 | 7 | 2.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(NS(C)(=O)=O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL304897 | 102254 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 631 | 10 | 3 | 7 | 2.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(NS(C)(=O)=O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL2369763 | 207936 | 8 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O | 10.1016/0960-894X(94)85022-4 | ||||
10027061 | 14783 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 456 | 4 | 1 | 3 | 5.3 | O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL120844 | 14783 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 456 | 4 | 1 | 3 | 5.3 | O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
44346175 | 12285 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 494 | 5 | 1 | 2 | 6.3 | Cc1cc(C)cc(C(=O)N[C@H]2CCN(C(=O)c3cc(Cl)cc(Cl)c3)[C@H](Cc3ccccc3)C2)c1 | 10.1021/jm9700171 | ||
CHEMBL118565 | 12285 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 494 | 5 | 1 | 2 | 6.3 | Cc1cc(C)cc(C(=O)N[C@H]2CCN(C(=O)c3cc(Cl)cc(Cl)c3)[C@H](Cc3ccccc3)C2)c1 | 10.1021/jm9700171 | ||
22293526 | 79297 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.4 | O=C(NC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2115452 | 79297 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.4 | O=C(NC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
68932391 | 124268 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 545 | 5 | 0 | 4 | 4.7 | COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 | nan | ||
CHEMBL3642165 | 124268 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 545 | 5 | 0 | 4 | 4.7 | COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 | nan | ||
10459262 | 4813 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 518 | 5 | 1 | 3 | 7.2 | Cc1cc2c(-c3ccccc3)c(CNCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
CHEMBL104435 | 4813 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 518 | 5 | 1 | 3 | 7.2 | Cc1cc2c(-c3ccccc3)c(CNCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
44370954 | 167769 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 558 | 10 | 1 | 6 | 4.5 | COC(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL434272 | 167769 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 558 | 10 | 1 | 6 | 4.5 | COC(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 | 10.1016/0960-894X(95)00080-D | ||
1122655 | 122582 | 22 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 421 | 6 | 1 | 6 | 4.7 | O=C(CSc1nnc(-c2ccncc2)n1-c1ccccc1)Nc1cccc(Cl)c1 | 10.1021/jm0311487 | ||
CHEMBL361031 | 122582 | 22 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 421 | 6 | 1 | 6 | 4.7 | O=C(CSc1nnc(-c2ccncc2)n1-c1ccccc1)Nc1cccc(Cl)c1 | 10.1021/jm0311487 | ||
21994363 | 118852 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 488 | 7 | 1 | 3 | 5.6 | COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1 | 10.1021/jm000986n | ||
CHEMBL344370 | 118852 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 488 | 7 | 1 | 3 | 5.6 | COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1 | 10.1021/jm000986n | ||
CHEMBL2112245 | 207488 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O | 10.1021/jm000316h | ||||
44308931 | 202635 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 255 | 5 | 1 | 2 | 3.5 | Cc1cc(C)cc(COC[C@H](N)c2ccccc2)c1 | 10.1016/S0960-894X(00)80063-3 | ||
CHEMBL71553 | 202635 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 255 | 5 | 1 | 2 | 3.5 | Cc1cc(C)cc(COC[C@H](N)c2ccccc2)c1 | 10.1016/S0960-894X(00)80063-3 | ||
CHEMBL2372517 | 208521 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O | 10.1021/jm00037a009 | ||||
44298065 | 194028 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 553 | 9 | 1 | 5 | 3.9 | CS(=O)(=O)N1CCC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)C1 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL55691 | 194028 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 553 | 9 | 1 | 5 | 3.9 | CS(=O)(=O)N1CCC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)C1 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL62581 | 214068 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||||
10769264 | 9126 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 562 | 10 | 2 | 3 | 5.0 | CN(CCc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL110508 | 9126 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 562 | 10 | 2 | 3 | 5.0 | CN(CCc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
25129135 | 172028 | 0 | None | -1584 | 4 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 1073 | 27 | 10 | 11 | 2.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 | 10.1021/jm800389v | ||
CHEMBL448998 | 172028 | 0 | None | -1584 | 4 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 1073 | 27 | 10 | 11 | 2.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 | 10.1021/jm800389v | ||
44384678 | 61042 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 697 | 11 | 1 | 8 | 6.2 | CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL176860 | 61042 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 697 | 11 | 1 | 8 | 6.2 | CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC | 10.1016/0960-894X(96)00148-5 | ||
19797431 | 37202 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 401 | 6 | 0 | 2 | 5.6 | Fc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
CHEMBL145514 | 37202 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 401 | 6 | 0 | 2 | 5.6 | Fc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
44299814 | 167399 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 415 | 3 | 1 | 2 | 5.0 | O=C1CO[C@@H](/C=C/c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccccc2)N1 | 10.1016/S0960-894X(01)80534-5 | ||
CHEMBL431725 | 167399 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 415 | 3 | 1 | 2 | 5.0 | O=C1CO[C@@H](/C=C/c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccccc2)N1 | 10.1016/S0960-894X(01)80534-5 | ||
11409185 | 98964 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 488 | 4 | 1 | 2 | 7.2 | Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL282853 | 98964 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 488 | 4 | 1 | 2 | 7.2 | Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
11329897 | 91466 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 522 | 5 | 1 | 2 | 7.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CCl)nc2ccccc2c1-c1ccccc1 | 10.1021/jm034219a | ||
CHEMBL24136 | 91466 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 522 | 5 | 1 | 2 | 7.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CCl)nc2ccccc2c1-c1ccccc1 | 10.1021/jm034219a | ||
10004190 | 129565 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 456 | 4 | 1 | 3 | 5.3 | O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
CHEMBL367711 | 129565 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 456 | 4 | 1 | 3 | 5.3 | O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
44287443 | 99808 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 528 | 9 | 0 | 5 | 4.9 | CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL288942 | 99808 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 528 | 9 | 0 | 5 | 4.9 | CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
16755255 | 188542 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 529 | 4 | 0 | 5 | 6.3 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL510547 | 188542 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 529 | 4 | 0 | 5 | 6.3 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 | 10.1016/j.bmc.2008.05.067 | ||
11642147 | 87788 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 521 | 7 | 0 | 2 | 7.9 | FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347690 | 87788 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 521 | 7 | 0 | 2 | 7.9 | FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
44288927 | 168213 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 503 | 6 | 1 | 3 | 6.5 | O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL43744 | 168213 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 503 | 6 | 1 | 3 | 6.5 | O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
44359109 | 31754 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 489 | 8 | 3 | 3 | 5.9 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)cc1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL140768 | 31754 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 489 | 8 | 3 | 3 | 5.9 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)cc1)c1ccccc1 | 10.1021/jm00022a010 | ||
44297563 | 193287 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 615 | 8 | 1 | 5 | 4.6 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL54435 | 193287 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 615 | 8 | 1 | 5 | 4.6 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44415393 | 79968 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 500 | 7 | 2 | 3 | 5.4 | O=C1CC[C@@H](CN[C@H]2CC[C@@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)N1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL214435 | 79968 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 500 | 7 | 2 | 3 | 5.4 | O=C1CC[C@@H](CN[C@H]2CC[C@@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)N1 | 10.1016/j.bmcl.2006.06.035 | ||
15755298 | 197039 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 732 | 15 | 4 | 9 | 5.0 | CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL58245 | 197039 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 732 | 15 | 4 | 9 | 5.0 | CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
71699789 | 124262 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 529 | 4 | 0 | 3 | 5.0 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL3642159 | 124262 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 529 | 4 | 0 | 3 | 5.0 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL2112245 | 207488 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O | 10.1021/jm000316h | ||||
44294394 | 11148 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 495 | 6 | 0 | 5 | 4.7 | CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
53838756 | 11148 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 495 | 6 | 0 | 5 | 4.7 | CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1178980 | 11148 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 495 | 6 | 0 | 5 | 4.7 | CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL52448 | 11148 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 495 | 6 | 0 | 5 | 4.7 | CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
44297753 | 162129 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 526 | 10 | 1 | 4 | 6.1 | COc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL417026 | 162129 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 526 | 10 | 1 | 4 | 6.1 | COc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
10318912 | 97042 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 402 | 4 | 0 | 1 | 7.0 | FC(F)(F)c1cc(CO[C@H]2CCCC[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL27026 | 97042 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 402 | 4 | 0 | 1 | 7.0 | FC(F)(F)c1cc(CO[C@H]2CCCC[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00220-N | ||
10249652 | 129211 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 388 | 4 | 1 | 3 | 4.3 | O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
CHEMBL367423 | 129211 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 388 | 4 | 1 | 3 | 4.3 | O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
15295989 | 59368 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 4 | 2 | 1 | 5.3 | O=C1NC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
CHEMBL172238 | 59368 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 4 | 2 | 1 | 5.3 | O=C1NC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
44324746 | 205567 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 565 | 14 | 1 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCOC)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL93251 | 205567 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 565 | 14 | 1 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCOC)C1 | 10.1016/S0960-894X(01)80747-2 | ||
44334185 | 4500 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 449 | 5 | 1 | 3 | 6.0 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL102525 | 4500 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 449 | 5 | 1 | 3 | 6.0 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
44346664 | 16376 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 388 | 4 | 1 | 3 | 4.3 | O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL123764 | 16376 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 388 | 4 | 1 | 3 | 4.3 | O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
44334185 | 4500 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 449 | 5 | 1 | 3 | 6.0 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 | 10.1021/jm9700171 | ||
CHEMBL102525 | 4500 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 449 | 5 | 1 | 3 | 6.0 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 | 10.1021/jm9700171 | ||
44297466 | 101436 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 567 | 9 | 1 | 5 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL300896 | 101436 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 567 | 9 | 1 | 5 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44333727 | 108731 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 493 | 7 | 1 | 4 | 5.9 | COc1cccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL321710 | 108731 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 493 | 7 | 1 | 4 | 5.9 | COc1cccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)c1 | 10.1016/S0960-894X(96)00563-X | ||
10627789 | 100112 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 630 | 18 | 3 | 7 | 5.3 | CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O | 10.1021/jm9800346 | ||
CHEMBL29161 | 100112 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 630 | 18 | 3 | 7 | 5.3 | CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O | 10.1021/jm9800346 | ||
24889458 | 8345 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 583 | 6 | 0 | 5 | 6.7 | CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1093594 | 8345 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 583 | 6 | 0 | 5 | 6.7 | CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 | 10.1016/j.bmcl.2010.01.120 | ||
10790827 | 119406 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 478 | 10 | 2 | 5 | 2.6 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCOCC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL349273 | 119406 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 478 | 10 | 2 | 5 | 2.6 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCOCC1)C(C)=O | 10.1021/jm950616c | ||
44306309 | 100525 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 622 | 8 | 2 | 5 | 4.9 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2cc(Cl)ccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL294342 | 100525 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 622 | 8 | 2 | 5 | 4.9 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2cc(Cl)ccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
10840510 | 164738 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 555 | 11 | 2 | 6 | 4.0 | COc1ccccc1CN(CC(CC1CNc2ccccc21)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL423254 | 164738 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 555 | 11 | 2 | 6 | 4.0 | COc1ccccc1CN(CC(CC1CNc2ccccc21)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
54581251 | 60823 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 472 | 4 | 1 | 2 | 6.7 | Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765495 | 60823 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 472 | 4 | 1 | 2 | 6.7 | Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
56681832 | 66145 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 5 | 0 | 2 | 6.2 | O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817833 | 66145 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 5 | 0 | 2 | 6.2 | O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852229 | 66145 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 5 | 0 | 2 | 6.2 | O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
21994308 | 30230 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 503 | 8 | 1 | 4 | 5.1 | COc1ccccc1C(CNC(=O)Cc1ccccc1C(F)(F)F)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL139256 | 30230 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 503 | 8 | 1 | 4 | 5.1 | COc1ccccc1C(CNC(=O)Cc1ccccc1C(F)(F)F)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
10506124 | 100790 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(00)80046-3 | ||
CHEMBL296228 | 100790 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(00)80046-3 | ||
44344995 | 96009 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 478 | 5 | 1 | 2 | 7.4 | Cc1cc(C)cc(/C(F)=C2\CC[C@@H](NC(=O)c3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
CHEMBL262301 | 96009 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 478 | 5 | 1 | 2 | 7.4 | Cc1cc(C)cc(/C(F)=C2\CC[C@@H](NC(=O)c3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
44290659 | 101063 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 654 | 8 | 1 | 7 | 5.7 | COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(00)00324-3 | ||
CHEMBL298247 | 101063 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 654 | 8 | 1 | 7 | 5.7 | COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(00)00324-3 | ||
CHEMBL264341 | 208869 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C/c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O | 10.1021/jm00037a009 | ||||
CHEMBL269584 | 209054 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CSCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O | 10.1021/jm00037a009 | ||||
44337703 | 110198 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 603 | 9 | 2 | 6 | 4.7 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(=N/c1ccccc1[N+](=O)[O-])NC#N | 10.1021/jm970499g | ||
CHEMBL326001 | 110198 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 603 | 9 | 2 | 6 | 4.7 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(=N/c1ccccc1[N+](=O)[O-])NC#N | 10.1021/jm970499g | ||
CHEMBL2369630 | 207900 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm000316h | ||||
44212285 | 123300 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 549 | 7 | 1 | 3 | 5.7 | NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL362394 | 123300 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 549 | 7 | 1 | 3 | 5.7 | NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 | 10.1016/0960-894X(96)00148-5 | ||
44276738 | 96742 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 560 | 6 | 0 | 2 | 7.9 | O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(98)00215-7 | ||
CHEMBL26831 | 96742 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 560 | 6 | 0 | 2 | 7.9 | O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(98)00215-7 | ||
10045837 | 61048 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 388 | 4 | 1 | 3 | 4.6 | O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(Cl)cc(Cl)c1 | 10.1021/jm00006a011 | ||
CHEMBL176919 | 61048 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 388 | 4 | 1 | 3 | 4.6 | O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(Cl)cc(Cl)c1 | 10.1021/jm00006a011 | ||
CHEMBL2369605 | 207893 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm960281e | ||||
16755280 | 176224 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 3.9 | COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL460683 | 176224 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 3.9 | COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 | 10.1016/j.bmc.2008.05.067 | ||
54584234 | 60833 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 479 | 4 | 1 | 5 | 5.1 | Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765503 | 60833 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 479 | 4 | 1 | 5 | 5.1 | Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL2114443 | 207511 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O | 10.1021/jm00037a009 | ||||
9851741 | 79783 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 604 | 7 | 1 | 2 | 8.0 | C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@@]12C=Cc1ccccc12 | 10.1021/jm060439n | ||
CHEMBL213601 | 79783 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 604 | 7 | 1 | 2 | 8.0 | C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@@]12C=Cc1ccccc12 | 10.1021/jm060439n | ||
CHEMBL2112242 | 207485 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm960281e | ||||
10456592 | 5227 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 453 | 4 | 1 | 3 | 6.1 | Cc1cc(C)cc(CN(C)C(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 | 10.1021/jm00016a014 | ||
CHEMBL106609 | 5227 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 453 | 4 | 1 | 3 | 6.1 | Cc1cc(C)cc(CN(C)C(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 | 10.1021/jm00016a014 | ||
56657842 | 62912 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 839 | 7 | 6 | 7 | 4.2 | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)C2C(=O)[C@@H](Cc3c2[nH]c2ccccc32)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCC2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm000316h | ||
CHEMBL1790897 | 62912 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 839 | 7 | 6 | 7 | 4.2 | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)C2C(=O)[C@@H](Cc3c2[nH]c2ccccc32)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCC2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm000316h | ||
44359260 | 114986 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 523 | 8 | 3 | 3 | 6.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)c(Cl)c1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL335106 | 114986 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 523 | 8 | 3 | 3 | 6.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)c(Cl)c1)c1ccccc1 | 10.1021/jm00022a010 | ||
10407571 | 167394 | 8 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
CHEMBL431690 | 167394 | 8 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
10047989 | 92065 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 424 | 7 | 2 | 5 | 4.4 | COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00035a006 | ||
CHEMBL24314 | 92065 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 424 | 7 | 2 | 5 | 4.4 | COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00035a006 | ||
56671766 | 66111 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 407 | 5 | 1 | 3 | 4.9 | O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817828 | 66111 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 407 | 5 | 1 | 3 | 4.9 | O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852010 | 66111 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 407 | 5 | 1 | 3 | 4.9 | O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
44303835 | 101296 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 11 | 1 | 3 | 5.7 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL299887 | 101296 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 11 | 1 | 3 | 5.7 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 | 10.1016/S0960-894X(01)80747-2 | ||
21256636 | 30013 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 503 | 8 | 1 | 4 | 5.4 | COc1ccccc1C(CNC(=O)Cc1ccc(Cl)c(Cl)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL139072 | 30013 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 503 | 8 | 1 | 4 | 5.4 | COc1ccccc1C(CNC(=O)Cc1ccc(Cl)c(Cl)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
10047989 | 92065 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 424 | 7 | 2 | 5 | 4.4 | COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00066a015 | ||
CHEMBL24314 | 92065 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 424 | 7 | 2 | 5 | 4.4 | COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00066a015 | ||
CHEMBL216813 | 207596 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O | 10.1021/jm00037a009 | ||||
44321430 | 106503 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00092a009 | ||
CHEMBL315176 | 106503 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00092a009 | ||
10811257 | 101357 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
CHEMBL300303 | 101357 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
44277705 | 101497 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
CHEMBL30139 | 101497 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
44306217 | 201353 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 538 | 8 | 3 | 4 | 3.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCC(O)CN1C(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL63471 | 201353 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 538 | 8 | 3 | 4 | 3.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCC(O)CN1C(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
44334111 | 109319 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 513 | 6 | 1 | 3 | 7.0 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cccc3ccccc23)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL323317 | 109319 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 513 | 6 | 1 | 3 | 7.0 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cccc3ccccc23)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL2372521 | 208524 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2ccccc21)C1c2ccccc2-c2ccccc21)C(N)=O | 10.1021/jm00037a009 | ||||
24801797 | 86999 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 476 | 6 | 0 | 5 | 4.8 | CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)C3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333627 | 86999 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 476 | 6 | 0 | 5 | 4.8 | CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)C3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
71541470 | 87007 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 6 | 0 | 3 | 5.5 | C/C=C/c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333635 | 87007 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 6 | 0 | 3 | 5.5 | C/C=C/c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
24801101 | 87014 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 402 | 5 | 1 | 3 | 4.7 | Fc1ccc(C2(COCc3cc(C(F)(F)F)cc(Cl)n3)CCNCC2)cc1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333642 | 87014 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 402 | 5 | 1 | 3 | 4.7 | Fc1ccc(C2(COCc3cc(C(F)(F)F)cc(Cl)n3)CCNCC2)cc1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL306072 | 209231 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O | 10.1016/0960-894X(94)85022-4 | ||||
67233125 | 125922 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 564 | 4 | 1 | 3 | 5.8 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)Nc3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL3651888 | 125922 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 564 | 4 | 1 | 3 | 5.8 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)Nc3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
71541575 | 86984 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 4.2 | CN1CCC(COCc2cc(C#N)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333612 | 86984 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 4.2 | CN1CCC(COCc2cc(C#N)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
44277705 | 101497 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80349-2 | ||
CHEMBL30139 | 101497 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 397 | 6 | 0 | 2 | 5.8 | Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80349-2 | ||
10649948 | 6610 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 532 | 9 | 2 | 3 | 4.5 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F | 10.1021/jm970499g | ||
CHEMBL108349 | 6610 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 532 | 9 | 2 | 3 | 4.5 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F | 10.1021/jm970499g | ||
18654560 | 111818 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 668 | 16 | 0 | 4 | 7.3 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL329168 | 111818 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 668 | 16 | 0 | 4 | 7.3 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80747-2 | ||
44349003 | 17807 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 443 | 1 | 1 | 4 | 6.0 | CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL126221 | 17807 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 443 | 1 | 1 | 4 | 6.0 | CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
10350454 | 106249 | 0 | None | - | 3 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 815 | 18 | 4 | 8 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144209 | 106249 | 0 | None | - | 3 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 815 | 18 | 4 | 8 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
44458353 | 99143 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 335 | 5 | 0 | 2 | 4.5 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL283979 | 99143 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 335 | 5 | 0 | 2 | 4.5 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(95)00205-8 | ||
10520658 | 98194 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 | 10.1021/jm00024a007 | ||
CHEMBL277260 | 98194 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 | 10.1021/jm00024a007 | ||
44337500 | 106705 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 604 | 9 | 2 | 4 | 6.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1cc2ccccc2s1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL316515 | 106705 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 604 | 9 | 2 | 4 | 6.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1cc2ccccc2s1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
44458328 | 99054 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm9700171 | ||
CHEMBL283356 | 99054 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm9700171 | ||
44286798 | 166878 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 451 | 5 | 0 | 1 | 6.6 | CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL42972 | 166878 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 451 | 5 | 0 | 1 | 6.6 | CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
10075002 | 4693 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 5.8 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc([N+](=O)[O-])cc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL103851 | 4693 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 5.8 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc([N+](=O)[O-])cc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
10027219 | 99121 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 6.1 | NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL283872 | 99121 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 6.1 | NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
24799364 | 86992 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 467 | 9 | 1 | 4 | 6.0 | CCC(CC)Nc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333620 | 86992 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 467 | 9 | 1 | 4 | 6.0 | CCC(CC)Nc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
9910432 | 133000 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 428 | 4 | 2 | 2 | 5.6 | FC(F)(F)c1cc(CNC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.026 | ||
CHEMBL370816 | 133000 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 428 | 4 | 2 | 2 | 5.6 | FC(F)(F)c1cc(CNC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.026 | ||
22724580 | 139638 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 429 | 4 | 1 | 2 | 6.1 | FC(F)(F)c1cc(COC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
CHEMBL380351 | 139638 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 429 | 4 | 1 | 2 | 6.1 | FC(F)(F)c1cc(COC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
44358719 | 29635 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 573 | 7 | 1 | 3 | 6.5 | Cc1c(F)cccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL138764 | 29635 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 573 | 7 | 1 | 3 | 6.5 | Cc1c(F)cccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44358742 | 30748 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 657 | 7 | 0 | 3 | 8.4 | CN(CC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL139854 | 30748 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 657 | 7 | 0 | 3 | 8.4 | CN(CC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
10603097 | 56198 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 4.0 | CC(=O)N(Cc1ccccc1[N+](=O)[O-])CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL163310 | 56198 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 4.0 | CC(=O)N(Cc1ccccc1[N+](=O)[O-])CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
10674548 | 57142 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 568 | 11 | 3 | 5 | 3.9 | CNC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL165510 | 57142 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 568 | 11 | 3 | 5 | 3.9 | CNC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
44305544 | 201385 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 5 | 1 | 2 | 8.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL63785 | 201385 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 5 | 1 | 2 | 8.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 | 10.1016/s0960-894x(02)00382-7 | ||
10457416 | 14717 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 470 | 7 | 2 | 2 | 5.5 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL120781 | 14717 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 470 | 7 | 2 | 2 | 5.5 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
10457416 | 14717 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 470 | 7 | 2 | 2 | 5.5 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL120781 | 14717 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 470 | 7 | 2 | 2 | 5.5 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
11225834 | 98752 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 502 | 4 | 0 | 2 | 7.5 | Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
CHEMBL281491 | 98752 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 502 | 4 | 0 | 2 | 7.5 | Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
10696382 | 121469 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 489 | 7 | 0 | 4 | 5.4 | COC(=O)CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL359214 | 121469 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 489 | 7 | 0 | 4 | 5.4 | COC(=O)CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL2115375 | 207522 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O | 10.1021/jm00037a009 | ||||
56668399 | 66134 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 451 | 7 | 0 | 4 | 5.2 | COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817886 | 66134 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 451 | 7 | 0 | 4 | 5.2 | COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852139 | 66134 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 451 | 7 | 0 | 4 | 5.2 | COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 | 10.1016/j.bmc.2011.07.014 | ||
10530699 | 119633 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 550 | 11 | 2 | 4 | 5.0 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CC=C(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL351253 | 119633 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 550 | 11 | 2 | 4 | 5.0 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CC=C(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
9831309 | 134741 | 1 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1021/jm058225d | ||
CHEMBL372587 | 134741 | 1 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1021/jm058225d | ||
153996 | 112171 | 2 | None | 3 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL330366 | 112171 | 2 | None | 3 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL539021 | 112171 | 2 | None | 3 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/0960-894X(96)00148-5 | ||
153996 | 112171 | 2 | None | - | 3 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL330366 | 112171 | 2 | None | - | 3 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL539021 | 112171 | 2 | None | - | 3 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
44338583 | 5719 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 468 | 6 | 1 | 3 | 5.2 | Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL107875 | 5719 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 468 | 6 | 1 | 3 | 5.2 | Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F | 10.1016/s0960-894x(02)00563-2 | ||
44338346 | 5794 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 364 | 6 | 1 | 3 | 4.2 | Clc1cc(Cl)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL107941 | 5794 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 364 | 6 | 1 | 3 | 4.2 | Clc1cc(Cl)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
44338587 | 7358 | 3 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 452 | 6 | 1 | 3 | 4.4 | Brc1cc(Br)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL108667 | 7358 | 3 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 452 | 6 | 1 | 3 | 4.4 | Brc1cc(Br)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
44359083 | 29186 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 473 | 8 | 3 | 3 | 5.4 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1F)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL138390 | 29186 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 473 | 8 | 3 | 3 | 5.4 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1F)c1ccccc1 | 10.1021/jm00022a010 | ||
57398781 | 70609 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 486 | 4 | 0 | 2 | 5.3 | CC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951619 | 70609 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 486 | 4 | 0 | 2 | 5.3 | CC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.11.048 | ||
24888943 | 7865 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 571 | 5 | 0 | 3 | 7.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090438 | 7865 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 571 | 5 | 0 | 3 | 7.1 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
52941489 | 17549 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 516 | 4 | 1 | 3 | 5.2 | C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1258623 | 17549 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 516 | 4 | 1 | 3 | 5.2 | C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
18709650 | 164695 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 501 | 11 | 3 | 5 | 4.0 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(O)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL42295 | 164695 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 501 | 11 | 3 | 5 | 4.0 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(O)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
9888665 | 121467 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 425 | 7 | 0 | 2 | 6.3 | Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL359206 | 121467 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 425 | 7 | 0 | 2 | 6.3 | Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
10721128 | 55993 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 537 | 10 | 2 | 4 | 4.4 | CC(=O)N(Cc1ccccc1C)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL162977 | 55993 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 537 | 10 | 2 | 4 | 4.4 | CC(=O)N(Cc1ccccc1C)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
10769745 | 57193 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 591 | 10 | 2 | 4 | 5.1 | CC(=O)N(Cc1ccccc1C(F)(F)F)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL165949 | 57193 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 591 | 10 | 2 | 4 | 5.1 | CC(=O)N(Cc1ccccc1C(F)(F)F)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm9700171 | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm9700171 | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm9700171 | ||
44297434 | 193304 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 599 | 9 | 1 | 4 | 5.8 | CS(=O)(=O)N1CC2(CCN(C(=O)C(CCCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL54602 | 193304 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 599 | 9 | 1 | 4 | 5.8 | CS(=O)(=O)N1CC2(CCN(C(=O)C(CCCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00006a012 | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00006a012 | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00006a012 | ||
44273822 | 75153 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 569 | 7 | 1 | 4 | 7.0 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCCCC3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL20430 | 75153 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 569 | 7 | 1 | 4 | 7.0 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCCCC3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL2372516 | 208520 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O | 10.1021/jm00037a009 | ||||
44289862 | 99887 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 541 | 13 | 2 | 5 | 4.9 | COc1ccc(C(=O)CCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL289600 | 99887 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 541 | 13 | 2 | 5 | 4.9 | COc1ccc(C(=O)CCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 | 10.1016/s0960-894x(01)00250-5 | ||
21994258 | 118898 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 577 | 7 | 1 | 3 | 6.4 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL344646 | 118898 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 577 | 7 | 1 | 3 | 6.4 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44328423 | 106887 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 5.7 | COc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL317761 | 106887 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 5.7 | COc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL426363 | 211597 | 0 | None | 26 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80246-2 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80246-2 | ||
58993517 | 121579 | 0 | None | - | 0 | Mongolian jird | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 469 | 8 | 1 | 3 | 6.6 | CCOc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596480 | 121579 | 0 | None | - | 0 | Mongolian jird | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 469 | 8 | 1 | 3 | 6.6 | CCOc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
44433794 | 166892 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 536 | 5 | 0 | 4 | 5.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ccncn2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL429798 | 166892 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 536 | 5 | 0 | 4 | 5.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ccncn2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
9927183 | 193932 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 322 | 5 | 2 | 3 | 3.7 | COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 | 10.1016/j.bmcl.2007.10.010 | ||
CHEMBL55591 | 193932 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 322 | 5 | 2 | 3 | 3.7 | COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 | 10.1016/j.bmcl.2007.10.010 | ||
15214194 | 5046 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 552 | 4 | 0 | 3 | 7.2 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL105629 | 5046 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 552 | 4 | 0 | 3 | 7.2 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1C | 10.1021/jm00016a014 | ||
10096063 | 107938 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 4 | 0 | 4 | 5.5 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(Cl)cc(Cl)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm00016a014 | ||
CHEMBL319874 | 107938 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 4 | 0 | 4 | 5.5 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(Cl)cc(Cl)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm00016a014 | ||
11757401 | 59631 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 555 | 9 | 2 | 4 | 4.8 | O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL173231 | 59631 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 555 | 9 | 2 | 4 | 4.8 | O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
2089 | 2725 | 21 | None | - | 5 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
3795 | 2725 | 21 | None | - | 5 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
5311311 | 2725 | 21 | None | - | 5 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
CHEMBL217406 | 2725 | 21 | None | - | 5 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
44415513 | 165215 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 446 | 5 | 2 | 2 | 5.2 | NC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL424709 | 165215 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 446 | 5 | 2 | 2 | 5.2 | NC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
44306327 | 12924 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 595 | 11 | 2 | 6 | 3.2 | CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 | 10.1021/jm00039a022 | ||
CHEMBL1189912 | 12924 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 595 | 11 | 2 | 6 | 3.2 | CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 | 10.1021/jm00039a022 | ||
CHEMBL539762 | 12924 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 595 | 11 | 2 | 6 | 3.2 | CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 | 10.1021/jm00039a022 | ||
44306196 | 100267 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 605 | 9 | 2 | 7 | 3.1 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL292715 | 100267 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 605 | 9 | 2 | 7 | 3.1 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
44306107 | 102362 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 606 | 8 | 2 | 5 | 4.2 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(C(F)(F)F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL305547 | 102362 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 606 | 8 | 2 | 5 | 4.2 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(C(F)(F)F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
18709663 | 165549 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 527 | 12 | 2 | 5 | 4.5 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(C(C)=O)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL42597 | 165549 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 527 | 12 | 2 | 5 | 4.5 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(C(C)=O)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
44370340 | 119042 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 640 | 17 | 3 | 5 | 5.1 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCNCC(N)=O)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL345866 | 119042 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 640 | 17 | 3 | 5 | 5.1 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCNCC(N)=O)C1 | 10.1016/0960-894X(95)00080-D | ||
19797460 | 120499 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.8 | Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL356518 | 120499 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.8 | Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
44305467 | 102339 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 430 | 5 | 1 | 2 | 5.8 | CN(C(=O)c1ccccc1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL305375 | 102339 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 430 | 5 | 1 | 2 | 5.8 | CN(C(=O)c1ccccc1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 | 10.1016/s0960-894x(02)00382-7 | ||
71720664 | 87010 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 383 | 5 | 1 | 2 | 5.2 | FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333638 | 87010 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 383 | 5 | 1 | 2 | 5.2 | FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1016/j.bmcl.2012.11.094 | ||
24784193 | 121580 | 0 | None | - | 0 | Mongolian jird | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 441 | 6 | 2 | 3 | 5.9 | Oc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596481 | 121580 | 0 | None | - | 0 | Mongolian jird | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 441 | 6 | 2 | 3 | 5.9 | Oc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
44456651 | 95006 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 533 | 5 | 1 | 4 | 6.6 | C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL257112 | 95006 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 533 | 5 | 1 | 4 | 6.6 | C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
73348949 | 90391 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 494 | 5 | 1 | 2 | 6.0 | Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
CHEMBL2392023 | 90391 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 494 | 5 | 1 | 2 | 6.0 | Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
44335354 | 4865 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 629 | 7 | 2 | 4 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 | 10.1016/s0960-894x(01)00631-x | ||
CHEMBL104708 | 4865 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 629 | 7 | 2 | 4 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 | 10.1016/s0960-894x(01)00631-x | ||
71458131 | 79274 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 589 | 7 | 2 | 3 | 5.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(00)00260-2 | ||
CHEMBL2115343 | 79274 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 589 | 7 | 2 | 3 | 5.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(00)00260-2 | ||
44276882 | 95778 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 550 | 8 | 1 | 3 | 7.3 | O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1cccnc1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL26086 | 95778 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 550 | 8 | 1 | 3 | 7.3 | O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1cccnc1 | 10.1016/0960-894X(95)00220-N | ||
71541687 | 86987 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 422 | 6 | 0 | 3 | 5.3 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333615 | 86987 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 422 | 6 | 0 | 3 | 5.3 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
57395687 | 68281 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 451 | 7 | 2 | 4 | 4.3 | CCNC(=O)N1CC[C@@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917846 | 68281 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 451 | 7 | 2 | 4 | 4.3 | CCNC(=O)N1CC[C@@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
44433790 | 89014 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 583 | 5 | 0 | 3 | 5.2 | CC(=O)N1CCC(C(=O)N2C[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL237100 | 89014 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 583 | 5 | 0 | 3 | 5.2 | CC(=O)N1CCC(C(=O)N2C[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
11114226 | 202845 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 537 | 10 | 3 | 4 | 7.0 | CC(C)C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 | 10.1021/jm010825z | ||
CHEMBL72895 | 202845 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 537 | 10 | 3 | 4 | 7.0 | CC(C)C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 | 10.1021/jm010825z | ||
10075851 | 59707 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 536 | 9 | 3 | 3 | 5.4 | O=C(Cc1c[nH]cn1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL173564 | 59707 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 536 | 9 | 3 | 3 | 5.4 | O=C(Cc1c[nH]cn1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80246-2 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80246-2 | ||
58993461 | 121578 | 0 | None | - | 0 | Mongolian jird | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 470 | 7 | 1 | 4 | 6.1 | O=[N+]([O-])c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596479 | 121578 | 0 | None | - | 0 | Mongolian jird | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 470 | 7 | 1 | 4 | 6.1 | O=[N+]([O-])c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
44370449 | 119392 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 760 | 20 | 2 | 6 | 7.0 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL349113 | 119392 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 760 | 20 | 2 | 6 | 7.0 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 | 10.1016/0960-894X(95)00080-D | ||
46884470 | 7912 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 580 | 5 | 1 | 3 | 6.5 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090652 | 7912 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 580 | 5 | 1 | 3 | 6.5 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
19098237 | 36890 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 533 | 7 | 0 | 2 | 7.7 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
CHEMBL145265 | 36890 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 533 | 7 | 0 | 2 | 7.7 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
44319086 | 13600 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 722 | 10 | 0 | 7 | 6.0 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL1194977 | 13600 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 722 | 10 | 0 | 7 | 6.0 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL553617 | 13600 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 722 | 10 | 0 | 7 | 6.0 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
25129135 | 172028 | 0 | None | -7 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1073 | 27 | 10 | 11 | 2.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 | 10.1021/jm800389v | ||
CHEMBL448998 | 172028 | 0 | None | -7 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1073 | 27 | 10 | 11 | 2.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 | 10.1021/jm800389v | ||
44334113 | 5194 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 548 | 7 | 1 | 4 | 5.9 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(=O)Nc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL106440 | 5194 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 548 | 7 | 1 | 4 | 5.9 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(=O)Nc3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
44326281 | 205459 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 377 | 5 | 1 | 2 | 5.1 | CC(N)(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL92524 | 205459 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 377 | 5 | 1 | 2 | 5.1 | CC(N)(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
44459032 | 90456 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 393 | 6 | 1 | 3 | 4.4 | CC(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
CHEMBL23926 | 90456 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 393 | 6 | 1 | 3 | 4.4 | CC(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
44318413 | 203970 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 395 | 2 | 1 | 3 | 4.4 | Fc1ccc([C@@H]2NCCOC23COC[C@H](c2cccc(C(F)(F)F)c2)C3)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL82220 | 203970 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 395 | 2 | 1 | 3 | 4.4 | Fc1ccc([C@@H]2NCCOC23COC[C@H](c2cccc(C(F)(F)F)c2)C3)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
24783424 | 121572 | 0 | None | - | 0 | Mongolian jird | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 493 | 6 | 1 | 2 | 7.2 | FC(F)(F)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596473 | 121572 | 0 | None | - | 0 | Mongolian jird | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 493 | 6 | 1 | 2 | 7.2 | FC(F)(F)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
10476776 | 108073 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 412 | 5 | 0 | 4 | 4.5 | COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL320231 | 108073 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 412 | 5 | 0 | 4 | 4.5 | COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
44288758 | 100642 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL295122 | 100642 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
107686 | 3327 | 37 | None | - | 2 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
3522 | 3327 | 37 | None | - | 2 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
CHEMBL131171 | 3327 | 37 | None | - | 2 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
44344231 | 113017 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 477 | 6 | 1 | 3 | 6.4 | Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@H](C)c2ccccc2)c1 | 10.1016/S0960-894X(96)00623-3 | ||
CHEMBL332111 | 113017 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 477 | 6 | 1 | 3 | 6.4 | Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@H](C)c2ccccc2)c1 | 10.1016/S0960-894X(96)00623-3 | ||
44346159 | 14353 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 477 | 6 | 1 | 3 | 6.4 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2[C@H](C)c2ccccc2)c1 | 10.1021/jm9700171 | ||
CHEMBL120190 | 14353 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 477 | 6 | 1 | 3 | 6.4 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2[C@H](C)c2ccccc2)c1 | 10.1021/jm9700171 | ||
44177669 | 60932 | 0 | None | -52 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 1233 | 27 | 9 | 10 | 6.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766205 | 60932 | 0 | None | -52 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 1233 | 27 | 9 | 10 | 6.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
44319571 | 106557 | 1 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80280-8 | ||
CHEMBL315532 | 106557 | 1 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80280-8 | ||
44415437 | 79567 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 537 | 7 | 1 | 3 | 7.5 | O=C(N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)OCc1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL212697 | 79567 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 537 | 7 | 1 | 3 | 7.5 | O=C(N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)OCc1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
19797420 | 36629 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.5 | FC(F)(F)c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL145051 | 36629 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.5 | FC(F)(F)c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
10553958 | 100899 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
CHEMBL297068 | 100899 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
9915428 | 173061 | 2 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 546 | 15 | 4 | 4 | 5.1 | CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 | 10.1016/0960-894X(95)00313-I | ||
CHEMBL45340 | 173061 | 2 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 546 | 15 | 4 | 4 | 5.1 | CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 | 10.1016/0960-894X(95)00313-I | ||
44287895 | 100737 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 579 | 7 | 1 | 5 | 6.5 | COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL295845 | 100737 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 579 | 7 | 1 | 5 | 6.5 | COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
44304123 | 198893 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL59913 | 198893 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 | 10.1016/S0960-894X(01)80747-2 | ||
10405990 | 206383 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 356 | 5 | 0 | 2 | 4.9 | COC(=O)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 | 10.1016/S0960-894X(01)80821-0 | ||
CHEMBL98011 | 206383 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 356 | 5 | 0 | 2 | 4.9 | COC(=O)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 | 10.1016/S0960-894X(01)80821-0 | ||
9915428 | 173061 | 2 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 546 | 15 | 4 | 4 | 5.1 | CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 | 10.1021/jm950892r | ||
CHEMBL45340 | 173061 | 2 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 546 | 15 | 4 | 4 | 5.1 | CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 | 10.1021/jm950892r | ||
44287409 | 158503 | 1 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 437 | 5 | 1 | 1 | 6.9 | O=C(CC(c1ccccc1)c1ccccc1)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL40969 | 158503 | 1 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 437 | 5 | 1 | 1 | 6.9 | O=C(CC(c1ccccc1)c1ccccc1)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
44287368 | 154682 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 437 | 4 | 0 | 1 | 6.5 | CN(C(=O)C(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL40262 | 154682 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 437 | 4 | 0 | 1 | 6.5 | CN(C(=O)C(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
44287461 | 162144 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 493 | 8 | 0 | 1 | 7.3 | CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL41705 | 162144 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 493 | 8 | 0 | 1 | 7.3 | CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
44357469 | 161206 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 1329 | 41 | 13 | 19 | -1.6 | CSCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)Cc1noc([C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)n1 | 10.1021/jm990197+ | ||
CHEMBL413904 | 161206 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 1329 | 41 | 13 | 19 | -1.6 | CSCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)Cc1noc([C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)n1 | 10.1021/jm990197+ | ||
10367419 | 4338 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 6.6 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 | 10.1021/jm9700171 | ||
CHEMBL101420 | 4338 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 6.6 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 | 10.1021/jm9700171 | ||
11661655 | 105321 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.7 | N[C@@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126961 | 105321 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.7 | N[C@@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
10480944 | 59578 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 496 | 6 | 1 | 3 | 6.2 | C=CCC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm00006a011 | ||
CHEMBL173013 | 59578 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 496 | 6 | 1 | 3 | 6.2 | C=CCC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm00006a011 | ||
2089 | 2725 | 21 | None | - | 5 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
3795 | 2725 | 21 | None | - | 5 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
5311311 | 2725 | 21 | None | - | 5 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
CHEMBL217406 | 2725 | 21 | None | - | 5 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
44274341 | 81137 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 473 | 6 | 1 | 3 | 5.8 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL21611 | 81137 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 473 | 6 | 1 | 3 | 5.8 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
56681830 | 66129 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 421 | 6 | 0 | 3 | 5.2 | COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817830 | 66129 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 421 | 6 | 0 | 3 | 5.2 | COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852124 | 66129 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 421 | 6 | 0 | 3 | 5.2 | COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 | 10.1016/j.bmc.2011.07.014 | ||
10841047 | 57168 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 583 | 13 | 2 | 7 | 3.7 | COC(=O)CN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL165727 | 57168 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 583 | 13 | 2 | 7 | 3.7 | COC(=O)CN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
9918576 | 205606 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 764 | 14 | 0 | 10 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1021/jm058225d | ||
CHEMBL93556 | 205606 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 764 | 14 | 0 | 10 | 7.0 | COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1021/jm058225d | ||
CHEMBL2370873 | 208193 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCC(=O)N1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSC)C(N)=O | 10.1016/S0960-894X(01)80229-8 | ||||
44322406 | 164582 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 5 | 1 | 3 | 6.2 | O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL422773 | 164582 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 5 | 1 | 3 | 6.2 | O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
44322515 | 204989 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 476 | 6 | 1 | 2 | 5.6 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccc(F)cc1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL89818 | 204989 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 476 | 6 | 1 | 2 | 5.6 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccc(F)cc1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
10367419 | 4338 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 6.6 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL101420 | 4338 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 6.6 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 | 10.1016/S0960-894X(96)00563-X | ||
10460069 | 165785 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 6 | 1 | 2 | 6.8 | O=C1C(Cc2c[nH]c3ccccc23)N(Cc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
CHEMBL427295 | 165785 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 6 | 1 | 2 | 6.8 | O=C1C(Cc2c[nH]c3ccccc23)N(Cc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
44383815 | 59982 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 462 | 7 | 1 | 3 | 5.7 | COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/S0960-894X(00)80693-9 | ||
CHEMBL174365 | 59982 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 462 | 7 | 1 | 3 | 5.7 | COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/S0960-894X(00)80693-9 | ||
12736776 | 11052 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 410 | 5 | 0 | 3 | 5.9 | CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 | 10.1021/jm00085a015 | ||
53641783 | 11052 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 410 | 5 | 0 | 3 | 5.9 | CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 | 10.1021/jm00085a015 | ||
CHEMBL1178362 | 11052 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 410 | 5 | 0 | 3 | 5.9 | CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 | 10.1021/jm00085a015 | ||
CHEMBL23360 | 11052 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 410 | 5 | 0 | 3 | 5.9 | CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 | 10.1021/jm00085a015 | ||
44459024 | 11057 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 484 | 2 | 0 | 2 | 7.9 | CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C | 10.1021/jm00085a015 | ||
CHEMBL1178380 | 11057 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 484 | 2 | 0 | 2 | 7.9 | CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C | 10.1021/jm00085a015 | ||
CHEMBL24818 | 11057 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 484 | 2 | 0 | 2 | 7.9 | CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C | 10.1021/jm00085a015 | ||
16755254 | 185592 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 515 | 4 | 1 | 5 | 5.9 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2nnnc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL487259 | 185592 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 515 | 4 | 1 | 5 | 5.9 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2nnnc12 | 10.1016/j.bmc.2008.05.067 | ||
44386230 | 61034 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 735 | 8 | 1 | 4 | 7.2 | COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL176811 | 61034 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 735 | 8 | 1 | 4 | 7.2 | COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br | 10.1016/0960-894X(96)00148-5 | ||
10350528 | 106251 | 0 | None | - | 3 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 831 | 18 | 4 | 9 | 4.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144210 | 106251 | 0 | None | - | 3 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 831 | 18 | 4 | 9 | 4.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
44322511 | 106616 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 464 | 5 | 1 | 3 | 5.0 | O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL315937 | 106616 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 464 | 5 | 1 | 3 | 5.0 | O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 | 10.1016/s0960-894x(01)00727-2 | ||
44346557 | 113021 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 572 | 9 | 4 | 3 | 5.7 | O=C(Cc1ccccc1)N[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
CHEMBL332139 | 113021 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 572 | 9 | 4 | 3 | 5.7 | O=C(Cc1ccccc1)N[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
15295990 | 131585 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 455 | 4 | 2 | 2 | 4.9 | O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
CHEMBL369580 | 131585 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 455 | 4 | 2 | 2 | 4.9 | O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
54587143 | 60822 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 468 | 4 | 0 | 2 | 5.6 | Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765494 | 60822 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 468 | 4 | 0 | 2 | 5.6 | Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] | 10.1016/j.bmc.2011.02.031 | ||
11547090 | 87806 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 459 | 6 | 0 | 2 | 6.7 | CCN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347856 | 87806 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 459 | 6 | 0 | 2 | 6.7 | CCN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmc.2013.02.010 | ||
44306398 | 201854 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 527 | 11 | 2 | 4 | 3.4 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCCc1ccccc1 | 10.1021/jm00039a022 | ||
CHEMBL66592 | 201854 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 527 | 11 | 2 | 4 | 3.4 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCCc1ccccc1 | 10.1021/jm00039a022 | ||
10432488 | 4827 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 424 | 4 | 0 | 3 | 5.4 | Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccccc3C)c3ccccc3c(=O)n2C)c1 | 10.1021/jm00016a014 | ||
CHEMBL104513 | 4827 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 424 | 4 | 0 | 3 | 5.4 | Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccccc3C)c3ccccc3c(=O)n2C)c1 | 10.1021/jm00016a014 | ||
10026002 | 109196 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 435 | 4 | 0 | 4 | 4.7 | CN(Cc1ccccc1Cl)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL322714 | 109196 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 435 | 4 | 0 | 4 | 4.7 | CN(Cc1ccccc1Cl)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C | 10.1021/jm00016a014 | ||
44358442 | 29592 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 569 | 8 | 0 | 3 | 6.3 | CN(CC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL138727 | 29592 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 569 | 8 | 0 | 3 | 6.3 | CN(CC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
107686 | 3327 | 37 | None | -15 | 2 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
3522 | 3327 | 37 | None | -15 | 2 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
CHEMBL131171 | 3327 | 37 | None | -15 | 2 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
104943 | 55099 | 34 | None | - | 3 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
CHEMBL16192 | 55099 | 34 | None | - | 3 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
2089 | 2725 | 21 | None | - | 5 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80229-8 | ||||
3795 | 2725 | 21 | None | - | 5 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80229-8 | ||||
5311311 | 2725 | 21 | None | - | 5 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80229-8 | ||||
CHEMBL217406 | 2725 | 21 | None | - | 5 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80229-8 | ||||
CHEMBL263185 | 208816 | 4 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O | 10.1021/jm070577s | ||||
44270482 | 11877 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 499 | 10 | 1 | 4 | 5.2 | CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
CHEMBL1183073 | 11877 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 499 | 10 | 1 | 4 | 5.2 | CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
CHEMBL278455 | 11877 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 499 | 10 | 1 | 4 | 5.2 | CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
12736777 | 11051 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 426 | 5 | 0 | 3 | 6.6 | CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 | 10.1021/jm00085a015 | ||
54433543 | 11051 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 426 | 5 | 0 | 3 | 6.6 | CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 | 10.1021/jm00085a015 | ||
CHEMBL1178360 | 11051 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 426 | 5 | 0 | 3 | 6.6 | CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 | 10.1021/jm00085a015 | ||
CHEMBL23287 | 11051 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 426 | 5 | 0 | 3 | 6.6 | CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 | 10.1021/jm00085a015 | ||
44348666 | 112993 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 453 | 1 | 1 | 4 | 5.6 | C#CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL331978 | 112993 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 453 | 1 | 1 | 4 | 5.6 | C#CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
44348801 | 112969 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 489 | 0 | 1 | 4 | 6.4 | C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nc7cc8ccccc8cc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL331934 | 112969 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 489 | 0 | 1 | 4 | 6.4 | C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nc7cc8ccccc8cc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
44337421 | 108041 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 534 | 8 | 2 | 3 | 5.1 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL320029 | 108041 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 534 | 8 | 2 | 3 | 5.1 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Cl | 10.1021/jm970499g | ||
44287388 | 155466 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 479 | 7 | 0 | 1 | 6.9 | CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL40620 | 155466 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 479 | 7 | 0 | 1 | 6.9 | CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
44297492 | 192890 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 576 | 10 | 1 | 6 | 3.8 | CN(C)c1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL52717 | 192890 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 576 | 10 | 1 | 6 | 3.8 | CN(C)c1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 | 10.1016/s0960-894x(98)00320-5 | ||
131871 | 119023 | 6 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 450 | 6 | 1 | 2 | 6.1 | FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL345711 | 119023 | 6 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 450 | 6 | 1 | 2 | 6.1 | FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
44306416 | 100116 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 468 | 9 | 3 | 3 | 3.3 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL291634 | 100116 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 468 | 9 | 3 | 3 | 3.3 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
44370769 | 49747 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 507 | 12 | 1 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL156933 | 49747 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 507 | 12 | 1 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/0960-894X(95)00080-D | ||
19797413 | 36627 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 419 | 6 | 0 | 2 | 5.8 | Fc1cc(F)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL145050 | 36627 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 419 | 6 | 0 | 2 | 5.8 | Fc1cc(F)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
10552574 | 119474 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 476 | 10 | 2 | 4 | 3.7 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCCCC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL349882 | 119474 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 476 | 10 | 2 | 4 | 3.7 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCCCC1)C(C)=O | 10.1021/jm950616c | ||
44359259 | 24916 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 489 | 8 | 3 | 3 | 5.9 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1Cl)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL134737 | 24916 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 489 | 8 | 3 | 3 | 5.9 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1Cl)c1ccccc1 | 10.1021/jm00022a010 | ||
44275987 | 98885 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
CHEMBL282331 | 98885 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
9892852 | 83960 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL22194 | 83960 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00205-8 | ||
44297939 | 101206 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 9 | 1 | 3 | 6.4 | Cc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL299312 | 101206 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 9 | 1 | 3 | 6.4 | Cc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
71699788 | 124261 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 5 | 0 | 4 | 4.7 | COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 | nan | ||
CHEMBL3642158 | 124261 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 5 | 0 | 4 | 4.7 | COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 | nan | ||
44289256 | 100065 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 449 | 7 | 1 | 3 | 5.2 | O=C(Cc1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL291298 | 100065 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 449 | 7 | 1 | 3 | 5.2 | O=C(Cc1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
44270549 | 11035 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 503 | 9 | 1 | 2 | 6.8 | COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
CHEMBL1178214 | 11035 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 503 | 9 | 1 | 2 | 6.8 | COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
CHEMBL15970 | 11035 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 503 | 9 | 1 | 2 | 6.8 | COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80246-8 | ||
44312145 | 203010 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 520 | 7 | 3 | 2 | 5.1 | O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL74176 | 203010 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 520 | 7 | 3 | 2 | 5.1 | O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00395-3 | ||
10793140 | 57114 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 568 | 10 | 1 | 5 | 5.0 | COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL165308 | 57114 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 568 | 10 | 1 | 5 | 5.0 | COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(C)=O | 10.1021/jm950616c | ||
44297604 | 101165 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 635 | 9 | 1 | 5 | 5.7 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL299016 | 101165 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 635 | 9 | 1 | 5 | 5.7 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44276732 | 99543 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 565 | 8 | 2 | 3 | 7.1 | O=C(NCc1cccnc1)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL286747 | 99543 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 565 | 8 | 2 | 3 | 7.1 | O=C(NCc1cccnc1)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
24801102 | 87019 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 350 | 5 | 1 | 3 | 4.2 | Clc1cc(COCC2(c3ccccc3)CCNCC2)cc(Cl)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333647 | 87019 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 350 | 5 | 1 | 3 | 4.2 | Clc1cc(COCC2(c3ccccc3)CCNCC2)cc(Cl)n1 | 10.1016/j.bmcl.2012.11.094 | ||
46884468 | 7910 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 578 | 5 | 0 | 3 | 7.5 | Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090650 | 7910 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 578 | 5 | 0 | 3 | 7.5 | Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 | 10.1016/j.bmcl.2010.01.120 | ||
44289441 | 100639 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 4.9 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccccc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL295107 | 100639 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 4.9 | COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccccc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
10453364 | 5328 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 396 | 4 | 0 | 3 | 4.8 | Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2)n(C)c(=O)c2ccccc12 | 10.1021/jm00016a014 | ||
CHEMBL107145 | 5328 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 396 | 4 | 0 | 3 | 4.8 | Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2)n(C)c(=O)c2ccccc12 | 10.1021/jm00016a014 | ||
10433381 | 5509 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 440 | 6 | 0 | 4 | 5.2 | CCN(Cc1ccccc1OC)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL107689 | 5509 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 440 | 6 | 0 | 4 | 5.2 | CCN(Cc1ccccc1OC)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
10350528 | 106251 | 0 | None | 251 | 3 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 831 | 18 | 4 | 9 | 4.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144210 | 106251 | 0 | None | 251 | 3 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 831 | 18 | 4 | 9 | 4.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
44305511 | 201277 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 566 | 5 | 1 | 2 | 7.9 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL63014 | 201277 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 566 | 5 | 1 | 2 | 7.9 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 | 10.1016/s0960-894x(02)00382-7 | ||
9823811 | 59600 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 426 | 7 | 1 | 3 | 5.5 | COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80693-9 | ||
CHEMBL173110 | 59600 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 426 | 7 | 1 | 3 | 5.5 | COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80693-9 | ||
44358814 | 30877 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 489 | 8 | 3 | 3 | 5.9 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(Cl)c1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL139977 | 30877 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 489 | 8 | 3 | 3 | 5.9 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(Cl)c1)c1ccccc1 | 10.1021/jm00022a010 | ||
44352062 | 18745 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
CHEMBL128586 | 18745 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
131954513 | 161529 | 31 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 357 | 2 | 0 | 4 | 4.3 | COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F | 10.1021/acsmedchemlett.7b00317 | ||
CHEMBL4160748 | 161529 | 31 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 357 | 2 | 0 | 4 | 4.3 | COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F | 10.1021/acsmedchemlett.7b00317 | ||
21121353 | 101003 | 0 | None | - | 3 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 625 | 14 | 4 | 7 | 2.0 | CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O | 10.1021/jm00063a015 | ||
CHEMBL297776 | 101003 | 0 | None | - | 3 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 625 | 14 | 4 | 7 | 2.0 | CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O | 10.1021/jm00063a015 | ||
54587142 | 60821 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 454 | 4 | 1 | 2 | 5.3 | Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765493 | 60821 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 454 | 4 | 1 | 2 | 5.3 | Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] | 10.1016/j.bmc.2011.02.031 | ||
44321519 | 205001 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00092a009 | ||
CHEMBL89897 | 205001 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00092a009 | ||
44321519 | 205001 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
CHEMBL89897 | 205001 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
44307089 | 201324 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 445 | 4 | 0 | 2 | 6.0 | CC(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL63278 | 201324 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 445 | 4 | 0 | 2 | 6.0 | CC(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL2112244 | 207487 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cn2ccc3ccccc32)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm960281e | ||||
76318226 | 105318 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 501 | 6 | 0 | 3 | 6.5 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)CC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126958 | 105318 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 501 | 6 | 0 | 3 | 6.5 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)CC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
44294338 | 11944 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 4.6 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
54307293 | 11944 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 4.6 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1183499 | 11944 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 4.6 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL300854 | 11944 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 4.6 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
11568372 | 204306 | 3 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80280-8 | ||
CHEMBL85047 | 204306 | 3 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.7 | FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80280-8 | ||
44380745 | 119792 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 4.3 | COc1ccc(CN[C@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL352697 | 119792 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 4.3 | COc1ccc(CN[C@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 | 10.1016/S0960-894X(01)80859-3 | ||
10245452 | 100718 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 320 | 4 | 1 | 2 | 3.1 | O=C1C(Cc2c[nH]c3ccccc23)OCCN1Cc1ccccc1 | 10.1016/0960-894X(95)00582-E | ||
CHEMBL295680 | 100718 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 320 | 4 | 1 | 2 | 3.1 | O=C1C(Cc2c[nH]c3ccccc23)OCCN1Cc1ccccc1 | 10.1016/0960-894X(95)00582-E | ||
9888665 | 121467 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 425 | 7 | 0 | 2 | 6.3 | Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL359206 | 121467 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 425 | 7 | 0 | 2 | 6.3 | Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
10506928 | 119713 | 0 | None | 39 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL352102 | 119713 | 0 | None | 39 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
44297498 | 101532 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 567 | 9 | 1 | 5 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL301630 | 101532 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 567 | 9 | 1 | 5 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
10552836 | 4123 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 483 | 6 | 0 | 3 | 7.2 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
CHEMBL100141 | 4123 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 483 | 6 | 0 | 3 | 7.2 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
58993657 | 121553 | 0 | None | - | 0 | Mongolian jird | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 431 | 6 | 1 | 6 | 3.7 | Cn1nnc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596454 | 121553 | 0 | None | - | 0 | Mongolian jird | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 431 | 6 | 1 | 6 | 3.7 | Cn1nnc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2015.04.098 | ||
16755228 | 173132 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 526 | 4 | 0 | 2 | 8.1 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cccc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL453581 | 173132 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 526 | 4 | 0 | 2 | 8.1 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cccc12 | 10.1016/j.bmc.2008.05.067 | ||
19797456 | 34246 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1ccc(C)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL142855 | 34246 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1ccc(C)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
44319249 | 204352 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 631 | 12 | 1 | 8 | 4.4 | COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL85499 | 204352 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 631 | 12 | 1 | 8 | 4.4 | COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC | 10.1016/S0960-894X(97)10013-0 | ||
44304176 | 201131 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 697 | 16 | 4 | 9 | 3.3 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL62357 | 201131 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 697 | 16 | 4 | 9 | 3.3 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
15154442 | 14051 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 436 | 5 | 0 | 2 | 6.8 | CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 | 10.1021/jm00085a015 | ||
53703341 | 14051 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 436 | 5 | 0 | 2 | 6.8 | CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 | 10.1021/jm00085a015 | ||
CHEMBL1198573 | 14051 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 436 | 5 | 0 | 2 | 6.8 | CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 | 10.1021/jm00085a015 | ||
CHEMBL23147 | 14051 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 436 | 5 | 0 | 2 | 6.8 | CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 | 10.1021/jm00085a015 | ||
10071902 | 108914 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 439 | 5 | 1 | 3 | 5.5 | Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)CCc3ccccc3)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
CHEMBL321979 | 108914 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 439 | 5 | 1 | 3 | 5.5 | Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)CCc3ccccc3)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
CHEMBL2369630 | 207900 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm000316h | ||||
44346480 | 114364 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 317 | 7 | 1 | 2 | 4.4 | N[C@H](COCc1ccccc1)C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL334189 | 114364 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 317 | 7 | 1 | 2 | 4.4 | N[C@H](COCc1ccccc1)C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL2369767 | 207939 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | None | None | None | C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O | 10.1016/0960-894X(94)85022-4 | ||||
44299298 | 194575 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 317 | 7 | 1 | 2 | 4.4 | NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL56176 | 194575 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 317 | 7 | 1 | 2 | 4.4 | NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
15037918 | 44600 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 400 | 6 | 1 | 2 | 5.2 | Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL152239 | 44600 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 400 | 6 | 1 | 2 | 5.2 | Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
19797436 | 36606 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 461 | 6 | 0 | 2 | 6.3 | Brc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
CHEMBL145030 | 36606 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 461 | 6 | 0 | 2 | 6.3 | Brc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
19797448 | 37011 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 401 | 6 | 0 | 2 | 5.6 | Fc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL145360 | 37011 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 401 | 6 | 0 | 2 | 5.6 | Fc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
44358500 | 31297 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 539 | 9 | 0 | 8 | 4.2 | COc1cc(C(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)cc(OC)c1OC | 10.1021/jm000986n | ||
CHEMBL140360 | 31297 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 539 | 9 | 0 | 8 | 4.2 | COc1cc(C(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)cc(OC)c1OC | 10.1021/jm000986n | ||
44287861 | 161190 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 5 | 1 | 4 | 4.4 | CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL41375 | 161190 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 5 | 1 | 4 | 4.4 | CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
19797446 | 34322 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.5 | FC(F)(F)c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
CHEMBL142919 | 34322 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.5 | FC(F)(F)c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
10793492 | 110814 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 587 | 10 | 4 | 3 | 4.7 | O=C(NCCc1c[nH]c2ccccc12)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL326649 | 110814 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 587 | 10 | 4 | 3 | 4.7 | O=C(NCCc1c[nH]c2ccccc12)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl | 10.1021/jm970499g | ||
44358426 | 30669 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 595 | 6 | 0 | 3 | 7.3 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(c1ccccc1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL139753 | 30669 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 595 | 6 | 0 | 3 | 7.3 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(c1ccccc1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
10336036 | 111854 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 318 | 4 | 1 | 1 | 3.8 | O=C(Cc1c[nH]c2ccccc12)N1CCC(Cc2ccccc2)C1 | 10.1016/S0960-894X(96)00570-7 | ||
CHEMBL32940 | 111854 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 318 | 4 | 1 | 1 | 3.8 | O=C(Cc1c[nH]c2ccccc12)N1CCC(Cc2ccccc2)C1 | 10.1016/S0960-894X(96)00570-7 | ||
44359055 | 32116 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 584 | 10 | 4 | 5 | 6.3 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(CNC(=O)OC(C)(C)C)cc1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL141050 | 32116 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 584 | 10 | 4 | 5 | 6.3 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(CNC(=O)OC(C)(C)C)cc1)c1ccccc1 | 10.1021/jm00022a010 | ||
10501444 | 101407 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
CHEMBL300722 | 101407 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
44287555 | 158254 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 451 | 6 | 1 | 1 | 6.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL40944 | 158254 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 451 | 6 | 1 | 1 | 6.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
23294214 | 168594 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 590 | 7 | 1 | 4 | 6.9 | O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(98)00215-7 | ||
CHEMBL440465 | 168594 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 590 | 7 | 1 | 4 | 6.9 | O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(98)00215-7 | ||
76332769 | 105327 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 8 | 0 | 2 | 7.5 | CCN(CC)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126967 | 105327 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 8 | 0 | 2 | 7.5 | CCN(CC)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2014.01.036 | ||
10646925 | 30767 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 407 | 5 | 1 | 2 | 4.1 | Ic1cccc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
CHEMBL139868 | 30767 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 407 | 5 | 1 | 2 | 4.1 | Ic1cccc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
44287895 | 100737 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 579 | 7 | 1 | 5 | 6.5 | COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL295845 | 100737 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 579 | 7 | 1 | 5 | 6.5 | COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
16755230 | 172406 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 527 | 4 | 0 | 3 | 7.5 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2ccnc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL451773 | 172406 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 527 | 4 | 0 | 3 | 7.5 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2ccnc12 | 10.1016/j.bmc.2008.05.067 | ||
24801459 | 87003 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 389 | 5 | 0 | 4 | 4.2 | CN1CCC(COCc2cc(C(F)(F)F)cc(C#N)n2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333631 | 87003 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 389 | 5 | 0 | 4 | 4.2 | CN1CCC(COCc2cc(C(F)(F)F)cc(C#N)n2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
15755301 | 100601 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 630 | 15 | 4 | 7 | 3.3 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL294814 | 100601 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 630 | 15 | 4 | 7 | 3.3 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
44345010 | 14332 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 2 | 7.4 | Cc1cc(C)cc(/C(F)=C2/CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
CHEMBL120126 | 14332 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 2 | 7.4 | Cc1cc(C)cc(/C(F)=C2/CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
10041813 | 96506 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 322 | 7 | 2 | 3 | 3.4 | CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 | 10.1021/jm00035a006 | ||
CHEMBL26623 | 96506 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 322 | 7 | 2 | 3 | 3.4 | CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 | 10.1021/jm00035a006 | ||
10041813 | 96506 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 322 | 7 | 2 | 3 | 3.4 | CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 | 10.1021/jm00066a015 | ||
CHEMBL26623 | 96506 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 322 | 7 | 2 | 3 | 3.4 | CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 | 10.1021/jm00066a015 | ||
44297822 | 193354 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 603 | 12 | 2 | 5 | 4.8 | CS(=O)(=O)NCC1(c2ccccc2)CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL54931 | 193354 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 603 | 12 | 2 | 5 | 4.8 | CS(=O)(=O)NCC1(c2ccccc2)CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
44321099 | 204503 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 0 | 3 | 5.4 | COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
CHEMBL86659 | 204503 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 0 | 3 | 5.4 | COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
15755334 | 96114 | 0 | None | - | 0 | Guinea pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 578 | 13 | 6 | 6 | 1.6 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a011 | ||
CHEMBL263013 | 96114 | 0 | None | - | 0 | Guinea pig | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 578 | 13 | 6 | 6 | 1.6 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a011 | ||
44177670 | 60933 | 0 | None | -190 | 4 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 1151 | 27 | 10 | 10 | 5.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766206 | 60933 | 0 | None | -190 | 4 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 1151 | 27 | 10 | 10 | 5.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
71541471 | 87008 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 436 | 6 | 0 | 3 | 5.8 | CC(C)=Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333636 | 87008 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 436 | 6 | 0 | 3 | 5.8 | CC(C)=Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
71452815 | 79302 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 4.3 | COc1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL2115528 | 79302 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 4.3 | COc1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 | 10.1016/S0960-894X(01)80859-3 | ||
44328405 | 105717 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 456 | 6 | 1 | 2 | 6.4 | Clc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL313863 | 105717 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 456 | 6 | 1 | 2 | 6.4 | Clc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
44338646 | 9066 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 474 | 7 | 1 | 3 | 6.0 | CC(C)c1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL110086 | 9066 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 474 | 7 | 1 | 3 | 6.0 | CC(C)c1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
10552836 | 4123 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 483 | 6 | 0 | 3 | 7.2 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL100141 | 4123 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 483 | 6 | 0 | 3 | 7.2 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
10576866 | 111003 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 485 | 6 | 1 | 5 | 5.2 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL327736 | 111003 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 485 | 6 | 1 | 5 | 5.2 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
44294398 | 11139 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 5 | 0 | 4 | 5.6 | CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 | 10.1021/jm00109a034 | ||
54220048 | 11139 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 5 | 0 | 4 | 5.6 | CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 | 10.1021/jm00109a034 | ||
CHEMBL1178902 | 11139 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 5 | 0 | 4 | 5.6 | CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 | 10.1021/jm00109a034 | ||
CHEMBL48734 | 11139 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 5 | 0 | 4 | 5.6 | CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 | 10.1021/jm00109a034 | ||
16755206 | 186057 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 512 | 4 | 1 | 2 | 7.7 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cccc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL488045 | 186057 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 512 | 4 | 1 | 2 | 7.7 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cccc12 | 10.1016/j.bmc.2008.05.067 | ||
44303938 | 201458 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 713 | 16 | 5 | 10 | 3.0 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL64166 | 201458 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 713 | 16 | 5 | 10 | 3.0 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
15154438 | 11056 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 4 | 0 | 2 | 6.4 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
53968534 | 11056 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 4 | 0 | 2 | 6.4 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
CHEMBL1178371 | 11056 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 4 | 0 | 2 | 6.4 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
CHEMBL23682 | 11056 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 4 | 0 | 2 | 6.4 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
44288936 | 157623 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 517 | 6 | 0 | 3 | 6.9 | CN(Cc1ccnc2ccccc12)[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL40875 | 157623 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 517 | 6 | 0 | 3 | 6.9 | CN(Cc1ccnc2ccccc12)[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
11409185 | 98964 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 488 | 4 | 1 | 2 | 7.2 | Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
CHEMBL282853 | 98964 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 488 | 4 | 1 | 2 | 7.2 | Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm034219a | ||
44287390 | 155232 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 437 | 5 | 1 | 1 | 6.3 | O=C(NCC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL40587 | 155232 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 437 | 5 | 1 | 1 | 6.3 | O=C(NCC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
44338557 | 9258 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 330 | 6 | 1 | 3 | 3.5 | Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL111244 | 9258 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 330 | 6 | 1 | 3 | 3.5 | Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00563-2 | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm061369n | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm061369n | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm061369n | ||
132837 | 2207 | 51 | None | -18 | 5 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm900473p | ||
9461 | 2207 | 51 | None | -18 | 5 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm900473p | ||
CHEMBL22870 | 2207 | 51 | None | -18 | 5 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm900473p | ||
132837 | 2207 | 51 | None | -18 | 5 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm800389v | ||
9461 | 2207 | 51 | None | -18 | 5 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm800389v | ||
CHEMBL22870 | 2207 | 51 | None | -18 | 5 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm800389v | ||
132837 | 2207 | 51 | None | -18 | 5 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2009.08.035 | ||
9461 | 2207 | 51 | None | -18 | 5 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL22870 | 2207 | 51 | None | -18 | 5 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2009.08.035 | ||
132837 | 2207 | 51 | None | -18 | 5 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm101023r | ||
9461 | 2207 | 51 | None | -18 | 5 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm101023r | ||
CHEMBL22870 | 2207 | 51 | None | -18 | 5 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm101023r | ||
11757401 | 59631 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 555 | 9 | 2 | 4 | 4.8 | O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL173231 | 59631 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 555 | 9 | 2 | 4 | 4.8 | O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
56671913 | 66135 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 439 | 6 | 0 | 3 | 5.3 | COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817888 | 66135 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 439 | 6 | 0 | 3 | 5.3 | COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852140 | 66135 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 439 | 6 | 0 | 3 | 5.3 | COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
46884473 | 7707 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 565 | 5 | 0 | 4 | 6.6 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089397 | 7707 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 565 | 5 | 0 | 4 | 6.6 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
10817203 | 57226 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 3.5 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)S(C)(=O)=O | 10.1021/jm950616c | ||
CHEMBL166240 | 57226 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 3.5 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)S(C)(=O)=O | 10.1021/jm950616c | ||
44305271 | 101774 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 528 | 4 | 0 | 2 | 7.0 | CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL303119 | 101774 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 528 | 4 | 0 | 2 | 7.0 | CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 | 10.1016/s0960-894x(02)00382-7 | ||
44319323 | 13635 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 5.1 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL1195230 | 13635 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 5.1 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL554092 | 13635 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 5.1 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL394671 | 210731 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O | 10.1021/jm070577s | ||||
CHEMBL394671 | 210731 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O | 10.1021/jm070577s | ||||
44433788 | 88105 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 541 | 5 | 1 | 3 | 4.9 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCNCC2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL235220 | 88105 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 541 | 5 | 1 | 3 | 4.9 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCNCC2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
44328425 | 168904 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 6.0 | COc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL442962 | 168904 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 6.0 | COc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
44233184 | 193100 | 0 | None | 12 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1343 | 32 | 15 | 16 | 1.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL538131 | 193100 | 0 | None | 12 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1343 | 32 | 15 | 16 | 1.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
9871754 | 5337 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
CHEMBL107172 | 5337 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80693-9 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80693-9 | ||
44410162 | 76776 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 443 | 4 | 1 | 2 | 6.6 | C[C@@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
CHEMBL207698 | 76776 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 443 | 4 | 1 | 2 | 6.6 | C[C@@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
44294261 | 79223 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 593 | 7 | 0 | 2 | 9.1 | Fc1ccc(C2CCN([C@H]3CC[C@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2115010 | 79223 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 593 | 7 | 0 | 2 | 9.1 | Fc1ccc(C2CCN([C@H]3CC[C@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 | 10.1016/s0960-894x(02)00249-4 | ||
10086982 | 115692 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 314 | 6 | 3 | 4 | 2.0 | O=C(N[C@@H](Cc1ccccc1)C(=O)NO)OCc1ccccc1 | 10.1021/ml5002954 | ||
CHEMBL3358422 | 115692 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 314 | 6 | 3 | 4 | 2.0 | O=C(N[C@@H](Cc1ccccc1)C(=O)NO)OCc1ccccc1 | 10.1021/ml5002954 | ||
10072926 | 109198 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 459 | 4 | 1 | 3 | 6.1 | Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3Cl)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
CHEMBL322718 | 109198 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 459 | 4 | 1 | 3 | 6.1 | Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3Cl)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
9871754 | 5337 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm990220r | ||
CHEMBL107172 | 5337 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm990220r | ||
134138503 | 153903 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 694 | 13 | 6 | 7 | 2.8 | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acsmedchemlett.6b00381 | ||
CHEMBL3932836 | 153903 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 694 | 13 | 6 | 7 | 2.8 | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acsmedchemlett.6b00381 | ||
CHEMBL3990081 | 153903 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 694 | 13 | 6 | 7 | 2.8 | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acsmedchemlett.6b00381 | ||
49863734 | 15160 | 0 | None | 13 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1477 | 21 | 11 | 14 | 6.8 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm100157m | ||
CHEMBL1214027 | 15160 | 0 | None | 13 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1477 | 21 | 11 | 14 | 6.8 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm100157m | ||
44326362 | 205566 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 377 | 5 | 1 | 2 | 5.5 | CC(OCC(N)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL93243 | 205566 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 377 | 5 | 1 | 2 | 5.5 | CC(OCC(N)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00476-A | ||
16755231 | 188405 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 527 | 4 | 0 | 3 | 7.5 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cncc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL508659 | 188405 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 527 | 4 | 0 | 3 | 7.5 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cncc12 | 10.1016/j.bmc.2008.05.067 | ||
44306219 | 102256 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 556 | 8 | 2 | 5 | 3.3 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL304901 | 102256 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 556 | 8 | 2 | 5 | 3.3 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
44358703 | 115564 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 625 | 7 | 0 | 4 | 7.3 | COc1ccccc1C(C1CCCCN1C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL335624 | 115564 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 625 | 7 | 0 | 4 | 7.3 | COc1ccccc1C(C1CCCCN1C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
9853506 | 12978 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 709 | 10 | 0 | 7 | 6.1 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL1190281 | 12978 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 709 | 10 | 0 | 7 | 6.1 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL540553 | 12978 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 709 | 10 | 0 | 7 | 6.1 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
9799676 | 194146 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 373 | 8 | 0 | 2 | 5.6 | Cc1cc(C)cc(COCC(C(c2ccccc2)c2ccccc2)N(C)C)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL55823 | 194146 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 373 | 8 | 0 | 2 | 5.6 | Cc1cc(C)cc(COCC(C(c2ccccc2)c2ccccc2)N(C)C)c1 | 10.1016/S0960-894X(01)80531-X | ||
44456748 | 168614 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 551 | 5 | 1 | 4 | 6.7 | C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL440587 | 168614 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 551 | 5 | 1 | 4 | 6.7 | C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
10071073 | 5279 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 425 | 4 | 0 | 4 | 4.8 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C)cc(C)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm00016a014 | ||
CHEMBL106904 | 5279 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 425 | 4 | 0 | 4 | 4.8 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C)cc(C)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm00016a014 | ||
44233410 | 193921 | 0 | None | 38 | 3 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1327 | 28 | 14 | 16 | 1.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL555504 | 193921 | 0 | None | 38 | 3 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1327 | 28 | 14 | 16 | 1.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
44433789 | 145601 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 583 | 5 | 0 | 3 | 5.2 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL391963 | 145601 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 583 | 5 | 0 | 3 | 5.2 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
10792813 | 57212 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 552 | 11 | 2 | 4 | 5.1 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL166144 | 57212 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 552 | 11 | 2 | 4 | 5.1 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
44319224 | 106593 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 722 | 10 | 0 | 7 | 6.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL315814 | 106593 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 722 | 10 | 0 | 7 | 6.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
10360490 | 88311 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 349 | 5 | 1 | 2 | 4.8 | Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
CHEMBL23617 | 88311 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 349 | 5 | 1 | 2 | 4.8 | Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
CHEMBL238168 | 208646 | 9 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(N)=O | 10.1021/jm070577s | ||||
10007035 | 79115 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 524 | 8 | 3 | 4 | 3.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@H](O)CN1C(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL2114031 | 79115 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 524 | 8 | 3 | 4 | 3.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@H](O)CN1C(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
10460415 | 116039 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 559 | 7 | 1 | 3 | 6.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL336261 | 116039 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 559 | 7 | 1 | 3 | 6.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(F)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
10745307 | 164854 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1cccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)c1 | 10.1021/jm950616c | ||
CHEMBL423824 | 164854 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 553 | 11 | 2 | 5 | 4.1 | COc1cccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)c1 | 10.1021/jm950616c | ||
CHEMBL238168 | 208646 | 9 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(N)=O | 10.1021/jm070577s | ||||
11547594 | 105336 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 6 | 0 | 2 | 7.2 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)C2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126975 | 105336 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 6 | 0 | 2 | 7.2 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)C2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
136043853 | 138386 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 528 | 8 | 2 | 5 | 5.8 | CN(Cc1n[nH]c(O)n1)C[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL378340 | 138386 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 528 | 8 | 2 | 5 | 5.8 | CN(Cc1n[nH]c(O)n1)C[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
58993634 | 121586 | 0 | None | - | 0 | Mongolian jird | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 522 | 6 | 1 | 3 | 6.6 | N#Cc1c(F)c(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c(F)c1F | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596487 | 121586 | 0 | None | - | 0 | Mongolian jird | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 522 | 6 | 1 | 3 | 6.6 | N#Cc1c(F)c(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c(F)c1F | 10.1016/j.bmcl.2015.04.098 | ||
10438407 | 100187 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 590 | 11 | 2 | 6 | 4.4 | CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL292190 | 100187 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 590 | 11 | 2 | 6 | 4.4 | CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
57395686 | 71273 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 408 | 7 | 1 | 4 | 4.6 | CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1917841 | 71273 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 408 | 7 | 1 | 4 | 4.6 | CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963411 | 71273 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 408 | 7 | 1 | 4 | 4.6 | CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 | 10.1016/j.bmc.2011.08.070 | ||
53249015 | 60830 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 550 | 5 | 0 | 4 | 6.1 | Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765500 | 60830 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 550 | 5 | 0 | 4 | 6.1 | Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
9939040 | 4941 | 5 | None | 2 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 623 | 7 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00631-x | ||
CHEMBL105060 | 4941 | 5 | None | 2 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 623 | 7 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00631-x | ||
44358864 | 30132 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 599 | 7 | 0 | 5 | 6.1 | CN(CC(c1ccc2c(c1)OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL139176 | 30132 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 599 | 7 | 0 | 5 | 6.1 | CN(CC(c1ccc2c(c1)OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
44319306 | 106613 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 5.1 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL315923 | 106613 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 5.1 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
44274183 | 82052 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 507 | 6 | 1 | 3 | 6.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)ccc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL21760 | 82052 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 507 | 6 | 1 | 3 | 6.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)ccc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
56661423 | 66121 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 459 | 5 | 0 | 2 | 6.2 | O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817832 | 66121 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 459 | 5 | 0 | 2 | 6.2 | O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852069 | 66121 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 459 | 5 | 0 | 2 | 6.2 | O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
136043849 | 138171 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 542 | 9 | 2 | 5 | 6.1 | CN(CC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)Cc1n[nH]c(O)n1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL377916 | 138171 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 542 | 9 | 2 | 5 | 6.1 | CN(CC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)Cc1n[nH]c(O)n1 | 10.1016/j.bmcl.2006.06.035 | ||
44306108 | 102363 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 606 | 8 | 2 | 5 | 4.2 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL305548 | 102363 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 606 | 8 | 2 | 5 | 4.2 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
22293578 | 186544 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 591 | 7 | 0 | 1 | 9.9 | Fc1ccc(C2CCN(C3CCC(CCCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL49175 | 186544 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 591 | 7 | 0 | 1 | 9.9 | Fc1ccc(C2CCN(C3CCC(CCCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 | 10.1016/s0960-894x(02)00249-4 | ||
44415424 | 140923 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 537 | 7 | 1 | 3 | 7.5 | O=C(N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)OCc1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL384244 | 140923 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 537 | 7 | 1 | 3 | 7.5 | O=C(N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)OCc1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
11498370 | 100707 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 654 | 8 | 1 | 7 | 5.7 | COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(00)00324-3 | ||
CHEMBL295615 | 100707 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 654 | 8 | 1 | 7 | 5.7 | COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(00)00324-3 | ||
15295987 | 130830 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 469 | 4 | 2 | 2 | 4.3 | O=C1NC(Cc2c[nH]c3ccccc23)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm00006a011 | ||
CHEMBL368804 | 130830 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 469 | 4 | 2 | 2 | 4.3 | O=C1NC(Cc2c[nH]c3ccccc23)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm00006a011 | ||
15755316 | 201204 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 703 | 16 | 4 | 9 | 3.7 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC1CCCCC1 | 10.1021/jm00089a011 | ||
CHEMBL62711 | 201204 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 703 | 16 | 4 | 9 | 3.7 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC1CCCCC1 | 10.1021/jm00089a011 | ||
44299298 | 194575 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 317 | 7 | 1 | 2 | 4.4 | NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 | 10.1021/jm0311487 | ||
CHEMBL56176 | 194575 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 317 | 7 | 1 | 2 | 4.4 | NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 | 10.1021/jm0311487 | ||
16755256 | 172529 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 529 | 4 | 1 | 5 | 6.2 | Cc1ccc(-c2c(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL452027 | 172529 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 529 | 4 | 1 | 5 | 6.2 | Cc1ccc(-c2c(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL2369599 | 207888 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm960281e | ||||
14986135 | 162849 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
CHEMBL419500 | 162849 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
44287606 | 100045 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 470 | 5 | 0 | 4 | 4.6 | CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL291146 | 100045 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 470 | 5 | 0 | 4 | 4.6 | CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
10228092 | 76952 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 6 | 1 | 4 | 5.4 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cnccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL20826 | 76952 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 6 | 1 | 4 | 5.4 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cnccc21 | 10.1016/s0960-894x(01)00182-2 | ||
58993510 | 121540 | 0 | None | - | 0 | Mongolian jird | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 426 | 6 | 1 | 3 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccn2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596200 | 121540 | 0 | None | - | 0 | Mongolian jird | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 426 | 6 | 1 | 3 | 5.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccn2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
54580277 | 60832 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 466 | 4 | 0 | 2 | 6.7 | Cc1cc(-c2ccccc2)c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765502 | 60832 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 466 | 4 | 0 | 2 | 6.7 | Cc1cc(-c2ccccc2)c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 | 10.1016/j.bmc.2011.02.031 | ||
9830535 | 205089 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 620 | 17 | 1 | 4 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL90416 | 205089 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 620 | 17 | 1 | 4 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 | 10.1016/S0960-894X(01)80747-2 | ||
9830535 | 205089 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 620 | 17 | 1 | 4 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL90416 | 205089 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 620 | 17 | 1 | 4 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 | 10.1016/0960-894X(95)00080-D | ||
44294324 | 12256 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 496 | 7 | 0 | 6 | 5.2 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
54414362 | 12256 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 496 | 7 | 0 | 6 | 5.2 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1185473 | 12256 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 496 | 7 | 0 | 6 | 5.2 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL416468 | 12256 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 496 | 7 | 0 | 6 | 5.2 | CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
71583095 | 87791 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 6.0 | FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347693 | 87791 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 6.0 | FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
71699791 | 124264 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 591 | 5 | 0 | 3 | 6.4 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL3642161 | 124264 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 591 | 5 | 0 | 3 | 6.4 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
44337667 | 108370 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 568 | 9 | 3 | 5 | 4.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
CHEMBL321021 | 108370 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 568 | 9 | 3 | 5 | 4.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
10744740 | 109175 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 528 | 9 | 2 | 3 | 4.6 | Cc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL322508 | 109175 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 528 | 9 | 2 | 3 | 4.6 | Cc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
15154446 | 11048 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 480 | 6 | 0 | 4 | 6.0 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
53746881 | 11048 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 480 | 6 | 0 | 4 | 6.0 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
CHEMBL1178355 | 11048 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 480 | 6 | 0 | 4 | 6.0 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
CHEMBL23073 | 11048 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 480 | 6 | 0 | 4 | 6.0 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
10318477 | 166756 | 36 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 | 10.1021/jm00035a006 | ||
CHEMBL429395 | 166756 | 36 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 | 10.1021/jm00035a006 | ||
10318477 | 166756 | 36 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 | 10.1021/jm00066a015 | ||
CHEMBL429395 | 166756 | 36 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 | 10.1021/jm00066a015 | ||
107686 | 3327 | 37 | None | 15 | 2 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
3522 | 3327 | 37 | None | 15 | 2 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
CHEMBL131171 | 3327 | 37 | None | 15 | 2 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
19797466 | 34375 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 417 | 6 | 0 | 2 | 6.2 | Clc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
CHEMBL142961 | 34375 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 417 | 6 | 0 | 2 | 6.2 | Clc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
44297701 | 101221 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL299388 | 101221 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
11489240 | 94846 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 518 | 5 | 1 | 3 | 6.7 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL25639 | 94846 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 518 | 5 | 1 | 3 | 6.7 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 | 10.1016/j.bmc.2011.02.031 | ||
44274520 | 82171 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 479 | 5 | 0 | 5 | 4.9 | COc1ccccc1N1CCN(C(=O)CCc2c3n(c4ccc(C)cc24)C(=O)c2ccccc2-3)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21788 | 82171 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 479 | 5 | 0 | 5 | 4.9 | COc1ccccc1N1CCN(C(=O)CCc2c3n(c4ccc(C)cc24)C(=O)c2ccccc2-3)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
44358861 | 118132 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 491 | 8 | 3 | 3 | 5.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)c(F)c1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL341681 | 118132 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 491 | 8 | 3 | 3 | 5.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)c(F)c1)c1ccccc1 | 10.1021/jm00022a010 | ||
15755299 | 100421 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 626 | 13 | 3 | 8 | 3.7 | CC(C)(C)OC(=O)NCC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL293726 | 100421 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 626 | 13 | 3 | 8 | 3.7 | CC(C)(C)OC(=O)NCC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
10325464 | 119629 | 0 | None | -25 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL351236 | 119629 | 0 | None | -25 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
44458828 | 11055 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 408 | 3 | 0 | 3 | 5.6 | CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 | 10.1021/jm00085a015 | ||
CHEMBL1178368 | 11055 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 408 | 3 | 0 | 3 | 5.6 | CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 | 10.1021/jm00085a015 | ||
CHEMBL23533 | 11055 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 408 | 3 | 0 | 3 | 5.6 | CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 | 10.1021/jm00085a015 | ||
44281769 | 109172 | 7 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 484 | 10 | 4 | 4 | 3.2 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/0960-894X(95)00582-E | ||
CHEMBL32248 | 109172 | 7 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 484 | 10 | 4 | 4 | 3.2 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/0960-894X(95)00582-E | ||
19098237 | 36890 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 533 | 7 | 0 | 2 | 7.7 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
CHEMBL145265 | 36890 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 533 | 7 | 0 | 2 | 7.7 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
10428330 | 169655 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 356 | 4 | 1 | 3 | 3.5 | O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(F)cc(F)c1 | 10.1021/jm00006a011 | ||
CHEMBL444552 | 169655 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 356 | 4 | 1 | 3 | 3.5 | O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(F)cc(F)c1 | 10.1021/jm00006a011 | ||
44297562 | 193367 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 629 | 9 | 1 | 5 | 4.6 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)Cc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL54940 | 193367 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 629 | 9 | 1 | 5 | 4.6 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)Cc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
10576866 | 111003 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 485 | 6 | 1 | 5 | 5.2 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
CHEMBL327736 | 111003 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 485 | 6 | 1 | 5 | 5.2 | FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9506534 | ||
46881600 | 7027 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 493 | 5 | 1 | 3 | 5.3 | CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1085196 | 7027 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 493 | 5 | 1 | 3 | 5.3 | CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO | 10.1016/j.bmcl.2010.01.065 | ||
44302017 | 197651 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 446 | 9 | 4 | 3 | 4.3 | CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 | 10.1016/S0960-894X(97)00346-6 | ||
CHEMBL59060 | 197651 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 446 | 9 | 4 | 3 | 4.3 | CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 | 10.1016/S0960-894X(97)00346-6 | ||
71541370 | 87013 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 432 | 5 | 0 | 3 | 5.6 | CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333641 | 87013 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 432 | 5 | 0 | 3 | 5.6 | CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
10404051 | 85620 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 325 | 6 | 1 | 3 | 3.1 | CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
CHEMBL23077 | 85620 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 325 | 6 | 1 | 3 | 3.1 | CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
10027661 | 59387 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 469 | 4 | 2 | 2 | 4.3 | O=C1CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C(Cc2c[nH]c3ccccc23)N1 | 10.1021/jm00006a011 | ||
CHEMBL172308 | 59387 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 469 | 4 | 2 | 2 | 4.3 | O=C1CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C(Cc2c[nH]c3ccccc23)N1 | 10.1021/jm00006a011 | ||
54585203 | 60831 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 452 | 4 | 1 | 2 | 6.3 | Cc1cc(-c2ccccc2)c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765501 | 60831 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 452 | 4 | 1 | 2 | 6.3 | Cc1cc(-c2ccccc2)c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 | 10.1016/j.bmc.2011.02.031 | ||
10053205 | 116085 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 547 | 4 | 0 | 4 | 6.8 | Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
CHEMBL336589 | 116085 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 547 | 4 | 0 | 4 | 6.8 | Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
46884469 | 7911 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 6 | 0 | 4 | 7.2 | COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090651 | 7911 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 594 | 6 | 0 | 4 | 7.2 | COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL2369630 | 207900 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm000316h | ||||
44344195 | 162808 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 475 | 5 | 1 | 3 | 6.2 | Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 | 10.1016/S0960-894X(96)00623-3 | ||
CHEMBL419232 | 162808 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 475 | 5 | 1 | 3 | 6.2 | Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 | 10.1016/S0960-894X(96)00623-3 | ||
CHEMBL307433 | 209234 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O | 10.1016/0960-894X(94)85022-4 | ||||
44328357 | 111049 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 490 | 6 | 1 | 2 | 7.0 | FC(F)(F)c1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL327943 | 111049 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 490 | 6 | 1 | 2 | 7.0 | FC(F)(F)c1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
44287556 | 99749 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 397 | 6 | 0 | 1 | 6.2 | CN(Cc1cc(Cl)cc(Cl)c1)C(=O)CC(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL288382 | 99749 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 397 | 6 | 0 | 1 | 6.2 | CN(Cc1cc(Cl)cc(Cl)c1)C(=O)CC(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
11641636 | 105337 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 6 | 0 | 3 | 6.1 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)C2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126976 | 105337 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 6 | 0 | 3 | 6.1 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)C2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
24801457 | 87015 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 416 | 5 | 0 | 3 | 5.1 | CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333643 | 87015 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 416 | 5 | 0 | 3 | 5.1 | CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
44415472 | 139071 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 460 | 7 | 2 | 3 | 4.6 | NC(=O)CN[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL379744 | 139071 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 460 | 7 | 2 | 3 | 4.6 | NC(=O)CN[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
44433781 | 89497 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 6.4 | CC(C)(C)OC(=O)N1CC[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL237992 | 89497 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 6.4 | CC(C)(C)OC(=O)N1CC[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2007.08.028 | ||
44303900 | 162354 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 751 | 15 | 3 | 10 | 3.9 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1C(C(=O)c2ccccc2)CC[C@H]1C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL417390 | 162354 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 751 | 15 | 3 | 10 | 3.9 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1C(C(=O)c2ccccc2)CC[C@H]1C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
15154449 | 11875 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.4 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
54080603 | 11875 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.4 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
CHEMBL1183064 | 11875 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.4 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
CHEMBL278135 | 11875 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.4 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 | 10.1021/jm00085a015 | ||
44297724 | 101453 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 585 | 8 | 1 | 4 | 5.4 | CS(=O)(=O)N1CC2(CCN(C(=O)C(CCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL301008 | 101453 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 585 | 8 | 1 | 4 | 5.4 | CS(=O)(=O)N1CC2(CCN(C(=O)C(CCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44286772 | 167276 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 6 | 1 | 1 | 6.2 | O=C(NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL43085 | 167276 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 6 | 1 | 1 | 6.2 | O=C(NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
56668295 | 66140 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 409 | 5 | 0 | 2 | 5.3 | O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817836 | 66140 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 409 | 5 | 0 | 2 | 5.3 | O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852171 | 66140 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 409 | 5 | 0 | 2 | 5.3 | O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
10393390 | 97825 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 576 | 8 | 0 | 3 | 7.6 | CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 | 10.1016/s0960-894x(98)00215-7 | ||
CHEMBL27463 | 97825 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 576 | 8 | 0 | 3 | 7.6 | CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 | 10.1016/s0960-894x(98)00215-7 | ||
10317867 | 4795 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 384 | 6 | 1 | 4 | 4.5 | COc1ccccc1CNCc1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL104345 | 4795 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 384 | 6 | 1 | 4 | 4.5 | COc1ccccc1CNCc1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
44287511 | 144205 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 5 | 0 | 1 | 6.5 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL39089 | 144205 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 5 | 0 | 1 | 6.5 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
24785190 | 121556 | 0 | None | - | 0 | Mongolian jird | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 415 | 6 | 1 | 3 | 5.8 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccco2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596457 | 121556 | 0 | None | - | 0 | Mongolian jird | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 415 | 6 | 1 | 3 | 5.8 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccco2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
52941506 | 17585 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
CHEMBL1258732 | 17585 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 530 | 4 | 1 | 3 | 5.7 | C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.07.058 | ||
76314659 | 105332 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 501 | 8 | 0 | 2 | 7.9 | CC(C)N(C(C)C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126971 | 105332 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 501 | 8 | 0 | 2 | 7.9 | CC(C)N(C(C)C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
44287819 | 100926 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 486 | 5 | 0 | 4 | 3.6 | CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)C(=O)C[S+]([O-])C2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL297244 | 100926 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 486 | 5 | 0 | 4 | 3.6 | CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)C(=O)C[S+]([O-])C2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
10386984 | 5341 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 412 | 5 | 1 | 4 | 4.5 | COc1ccccc1CNC(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL107220 | 5341 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 412 | 5 | 1 | 4 | 4.5 | COc1ccccc1CNC(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
10625208 | 55571 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 500 | 10 | 1 | 5 | 3.7 | COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccccc1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL162332 | 55571 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 500 | 10 | 1 | 5 | 3.7 | COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccccc1)C(C)=O | 10.1021/jm950616c | ||
76332768 | 105326 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 459 | 6 | 0 | 2 | 6.7 | CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126966 | 105326 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 459 | 6 | 0 | 2 | 6.7 | CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2014.01.036 | ||
44288896 | 168421 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 517 | 5 | 1 | 3 | 6.2 | O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL43912 | 168421 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 517 | 5 | 1 | 3 | 6.2 | O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL2372519 | 208523 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2cc3ccccc3cc21)C(N)=O | 10.1021/jm00037a009 | ||||
44277452 | 100613 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1ccc(C)c(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(00)80349-2 | ||
CHEMBL29487 | 100613 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 411 | 6 | 0 | 2 | 6.1 | Cc1ccc(C)c(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(00)80349-2 | ||
44348667 | 113829 | 1 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 0 | 1 | 4 | 5.2 | C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL124542 | 113829 | 1 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 0 | 1 | 4 | 5.2 | C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL333069 | 113829 | 1 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 0 | 1 | 4 | 5.2 | C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
44212283 | 59546 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 593 | 9 | 1 | 4 | 5.6 | COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL172915 | 59546 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 593 | 9 | 1 | 4 | 5.6 | COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/0960-894X(96)00148-5 | ||
71541371 | 87018 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 374 | 5 | 0 | 3 | 4.0 | CN1CCC(COCc2cncc(Br)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333646 | 87018 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 374 | 5 | 0 | 3 | 4.0 | CN1CCC(COCc2cncc(Br)c2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
10253192 | 4854 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 449 | 4 | 1 | 3 | 5.7 | CN(Cc1ccccc1Cl)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL104654 | 4854 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 449 | 4 | 1 | 3 | 5.7 | CN(Cc1ccccc1Cl)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
44312028 | 102379 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 558 | 9 | 1 | 5 | 5.1 | CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL305609 | 102379 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 558 | 9 | 1 | 5 | 5.1 | CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00395-3 | ||
10627355 | 119505 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 596 | 13 | 2 | 6 | 3.6 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C | 10.1021/jm950616c | ||
CHEMBL350151 | 119505 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 596 | 13 | 2 | 6 | 3.6 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C | 10.1021/jm950616c | ||
44328395 | 107026 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 490 | 6 | 1 | 2 | 6.7 | FC(F)(F)c1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL318629 | 107026 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 490 | 6 | 1 | 2 | 6.7 | FC(F)(F)c1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
19003169 | 102315 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 269 | 6 | 1 | 2 | 3.4 | Cc1cc(C)cc(COCC(N)Cc2ccccc2)c1 | 10.1016/S0960-894X(00)80063-3 | ||
CHEMBL305274 | 102315 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 269 | 6 | 1 | 2 | 3.4 | Cc1cc(C)cc(COCC(N)Cc2ccccc2)c1 | 10.1016/S0960-894X(00)80063-3 | ||
44321047 | 204461 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 336 | 6 | 1 | 3 | 3.5 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 | 10.1021/jm00092a009 | ||
CHEMBL86378 | 204461 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 336 | 6 | 1 | 3 | 3.5 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 | 10.1021/jm00092a009 | ||
44326328 | 205376 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 295 | 5 | 1 | 2 | 4.2 | N[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL92032 | 205376 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 295 | 5 | 1 | 2 | 4.2 | N[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
44346420 | 14190 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 473 | 5 | 0 | 3 | 4.8 | COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] | 10.1016/S0960-894X(01)80177-3 | ||
CHEMBL119990 | 14190 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 473 | 5 | 0 | 3 | 4.8 | COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] | 10.1016/S0960-894X(01)80177-3 | ||
107686 | 3327 | 37 | None | - | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
3522 | 3327 | 37 | None | - | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL131171 | 3327 | 37 | None | - | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
18782568 | 205551 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 321 | 3 | 1 | 3 | 4.0 | COc1ccccc1C1=CC2(CCCNC2c2ccccc2)OC1 | 10.1016/s0960-894x(02)00509-7 | ||
CHEMBL93184 | 205551 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 321 | 3 | 1 | 3 | 4.0 | COc1ccccc1C1=CC2(CCCNC2c2ccccc2)OC1 | 10.1016/s0960-894x(02)00509-7 | ||
24784955 | 121566 | 0 | None | - | 0 | Mongolian jird | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 6.1 | N#Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596467 | 121566 | 0 | None | - | 0 | Mongolian jird | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 6.1 | N#Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL311405 | 209353 | 15 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O | 10.1016/0960-894X(94)85022-4 | ||||
44305865 | 100217 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 582 | 10 | 3 | 6 | 2.7 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(CC(=O)O)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL292346 | 100217 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 582 | 10 | 3 | 6 | 2.7 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(CC(=O)O)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL2092883 | 207458 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | None | None | None | C[C@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm960281e | ||||
10258592 | 98750 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 639 | 7 | 0 | 4 | 6.8 | CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00215-7 | ||
CHEMBL281481 | 98750 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 639 | 7 | 0 | 4 | 6.8 | CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00215-7 | ||
44368172 | 121001 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 444 | 8 | 2 | 4 | 4.9 | FC(F)(F)c1cc(COC[C@@H](NCc2nc[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL358409 | 121001 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 444 | 8 | 2 | 4 | 4.9 | FC(F)(F)c1cc(COC[C@@H](NCc2nc[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(97)10163-9 | ||
10097954 | 131599 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 513 | 9 | 2 | 3 | 5.0 | CN(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
CHEMBL369601 | 131599 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 513 | 9 | 2 | 3 | 5.0 | CN(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00006a012 | ||
44287609 | 99897 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 503 | 6 | 0 | 5 | 5.4 | COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL289666 | 99897 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 503 | 6 | 0 | 5 | 5.4 | COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
24783681 | 121567 | 0 | None | - | 0 | Mongolian jird | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 443 | 6 | 1 | 2 | 6.4 | Fc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596468 | 121567 | 0 | None | - | 0 | Mongolian jird | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 443 | 6 | 1 | 2 | 6.4 | Fc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
44415458 | 79939 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 6 | 0 | 2 | 7.3 | FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCCCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL214317 | 79939 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 6 | 0 | 2 | 7.3 | FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCCCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.035 | ||
44415539 | 138450 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 474 | 5 | 1 | 2 | 5.8 | CN(C)C(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL378537 | 138450 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 474 | 5 | 1 | 2 | 5.8 | CN(C)C(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
44305864 | 201803 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 525 | 8 | 3 | 5 | 2.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1[nH]nc2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL66193 | 201803 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 525 | 8 | 3 | 5 | 2.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1[nH]nc2ccccc12 | 10.1021/jm00039a022 | ||
44358519 | 30542 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 531 | 9 | 1 | 4 | 6.1 | CC(C)Oc1cccc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 | 10.1021/jm000986n | ||
CHEMBL139569 | 30542 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 531 | 9 | 1 | 4 | 6.1 | CC(C)Oc1cccc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 | 10.1021/jm000986n | ||
44338584 | 8073 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 500 | 6 | 1 | 3 | 6.2 | FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL109183 | 8073 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 500 | 6 | 1 | 3 | 6.2 | FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00563-2 | ||
22353151 | 9043 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 6 | 1 | 3 | 4.9 | FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL109937 | 9043 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 6 | 1 | 3 | 4.9 | FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00563-2 | ||
44338618 | 108838 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 5.0 | Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL321892 | 108838 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 5.0 | Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 | 10.1016/s0960-894x(02)00563-2 | ||
44346558 | 15215 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 586 | 9 | 3 | 3 | 6.0 | CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
CHEMBL121459 | 15215 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 586 | 9 | 3 | 3 | 6.0 | CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm9700171 | ||
24889114 | 7669 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 569 | 5 | 0 | 5 | 6.5 | Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089081 | 7669 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 569 | 5 | 0 | 5 | 6.5 | Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 | 10.1016/j.bmcl.2010.01.120 | ||
11743365 | 106904 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 4 | 0 | 4 | 4.6 | Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccc(F)cc3)c3cccnc3c(=O)n2C)c1 | 10.1021/jm00016a014 | ||
CHEMBL317870 | 106904 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 4 | 0 | 4 | 4.6 | Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccc(F)cc3)c3cccnc3c(=O)n2C)c1 | 10.1021/jm00016a014 | ||
44178113 | 60935 | 0 | None | -12 | 3 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 1237 | 27 | 10 | 11 | 5.6 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766208 | 60935 | 0 | None | -12 | 3 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 1237 | 27 | 10 | 11 | 5.6 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
44274530 | 98476 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 549 | 7 | 0 | 4 | 7.5 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C(C)C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL279488 | 98476 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 549 | 7 | 0 | 4 | 7.5 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C(C)C)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
24782655 | 121569 | 0 | None | - | 0 | Mongolian jird | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 470 | 7 | 1 | 4 | 6.1 | O=[N+]([O-])c1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596470 | 121569 | 0 | None | - | 0 | Mongolian jird | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 470 | 7 | 1 | 4 | 6.1 | O=[N+]([O-])c1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
44415486 | 80502 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 499 | 7 | 3 | 4 | 5.8 | Oc1nc(CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)c[nH]1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL215315 | 80502 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 499 | 7 | 3 | 4 | 5.8 | Oc1nc(CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)c[nH]1 | 10.1016/j.bmcl.2006.06.035 | ||
44358469 | 30928 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 629 | 11 | 3 | 5 | 5.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N(CCO)CCO)CC1 | 10.1021/jm000986n | ||
CHEMBL140023 | 30928 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 629 | 11 | 3 | 5 | 5.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N(CCO)CCO)CC1 | 10.1021/jm000986n | ||
10623791 | 30689 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 459 | 5 | 0 | 2 | 5.8 | CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL139784 | 30689 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 459 | 5 | 0 | 2 | 5.8 | CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
71541572 | 86979 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 440 | 6 | 0 | 3 | 5.4 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333608 | 86979 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 440 | 6 | 0 | 3 | 5.4 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
71541573 | 86980 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 6 | 0 | 3 | 5.2 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333609 | 86980 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 6 | 0 | 3 | 5.2 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
22293463 | 100846 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 607 | 7 | 0 | 2 | 9.7 | CC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL296629 | 100846 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 607 | 7 | 0 | 2 | 9.7 | CC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
44415412 | 78316 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 461 | 5 | 1 | 3 | 5.9 | COC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL211257 | 78316 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 461 | 5 | 1 | 3 | 5.9 | COC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
10553136 | 164772 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 2.5 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL423464 | 164772 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 491 | 10 | 2 | 5 | 2.5 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C)CC1)C(C)=O | 10.1021/jm950616c | ||
46884516 | 7744 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 567 | 5 | 0 | 4 | 6.5 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089533 | 7744 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 567 | 5 | 0 | 4 | 6.5 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44306036 | 13656 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 553 | 8 | 3 | 6 | 2.7 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL1195366 | 13656 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 553 | 8 | 3 | 6 | 2.7 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL554413 | 13656 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 553 | 8 | 3 | 6 | 2.7 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
44306318 | 202088 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 508 | 8 | 2 | 3 | 4.2 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCN1C(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL68225 | 202088 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 508 | 8 | 2 | 3 | 4.2 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCN1C(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
44358545 | 27232 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 541 | 7 | 1 | 3 | 6.1 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL136832 | 27232 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 541 | 7 | 1 | 3 | 6.1 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
9976640 | 194953 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 373 | 8 | 0 | 2 | 5.6 | Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 | 10.1021/jm9700171 | ||
CHEMBL56427 | 194953 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 373 | 8 | 0 | 2 | 5.6 | Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 | 10.1021/jm9700171 | ||
9976640 | 194953 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 373 | 8 | 0 | 2 | 5.6 | Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL56427 | 194953 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 373 | 8 | 0 | 2 | 5.6 | Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 | 10.1016/S0960-894X(01)80531-X | ||
44274170 | 76719 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 7 | 1 | 4 | 7.1 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccncc3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL20736 | 76719 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 7 | 1 | 4 | 7.1 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccncc3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
44274199 | 98303 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 7 | 1 | 4 | 7.1 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3cccnc3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL278088 | 98303 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 7 | 1 | 4 | 7.1 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3cccnc3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
10392469 | 193186 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 538 | 10 | 3 | 5 | 5.6 | C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm010825z | ||
CHEMBL539928 | 193186 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 538 | 10 | 3 | 5 | 5.6 | C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm010825z | ||
44370928 | 47492 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 619 | 18 | 1 | 4 | 7.1 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL154803 | 47492 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 619 | 18 | 1 | 4 | 7.1 | CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 | 10.1016/0960-894X(95)00080-D | ||
10603392 | 57152 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 583 | 12 | 2 | 6 | 4.7 | CCOC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL165566 | 57152 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 583 | 12 | 2 | 6 | 4.7 | CCOC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
44274118 | 98497 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 473 | 6 | 1 | 3 | 5.8 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL279674 | 98497 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 473 | 6 | 1 | 3 | 5.8 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
57397019 | 71190 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 444 | 4 | 1 | 2 | 5.1 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1951617 | 71190 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 444 | 4 | 1 | 2 | 5.1 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.11.048 | ||
CHEMBL1962935 | 71190 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 444 | 4 | 1 | 2 | 5.1 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.11.048 | ||
46884519 | 8009 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 582 | 5 | 0 | 4 | 7.4 | Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1091342 | 8009 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 582 | 5 | 0 | 4 | 7.4 | Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 | 10.1016/j.bmcl.2010.01.120 | ||
24752434 | 9045 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
CHEMBL1099372 | 9045 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 491 | 4 | 1 | 3 | 5.1 | C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.065 | ||
10743826 | 118081 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 495 | 6 | 0 | 3 | 5.2 | CS(=O)(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
CHEMBL341656 | 118081 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 495 | 6 | 0 | 3 | 5.2 | CS(=O)(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1021/jm980376b | ||
44415484 | 168372 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.5 | N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL438789 | 168372 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.5 | N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
44326361 | 111005 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 8 | 1 | 3 | 4.4 | CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL327765 | 111005 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 8 | 1 | 3 | 4.4 | CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
44326361 | 111005 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 8 | 1 | 3 | 4.4 | CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL327765 | 111005 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 8 | 1 | 3 | 4.4 | CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
9874168 | 203991 | 3 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL82386 | 203991 | 3 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
23025461 | 66119 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.5 | COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852063 | 66119 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.5 | COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL3216952 | 66119 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.5 | COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
9805809 | 102613 | 6 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 495 | 8 | 3 | 4 | 6.0 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm010825z | ||
CHEMBL307488 | 102613 | 6 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 495 | 8 | 3 | 4 | 6.0 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 | 10.1021/jm010825z | ||
11844212 | 98196 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 590 | 7 | 1 | 2 | 7.7 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC2(C=Cc3ccccc32)CC1)c1ccc(F)cc1 | 10.1021/jm060439n | ||
CHEMBL277279 | 98196 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 590 | 7 | 1 | 2 | 7.7 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC2(C=Cc3ccccc32)CC1)c1ccc(F)cc1 | 10.1021/jm060439n | ||
44348667 | 113829 | 1 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 0 | 1 | 4 | 5.2 | C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL124542 | 113829 | 1 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 0 | 1 | 4 | 5.2 | C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL333069 | 113829 | 1 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 0 | 1 | 4 | 5.2 | C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
44338652 | 108123 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 4.9 | COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL320544 | 108123 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 4.9 | COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 | 10.1016/s0960-894x(02)00563-2 | ||
44322736 | 205273 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 448 | 6 | 1 | 2 | 6.1 | Fc1ccc(N(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL91436 | 205273 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 448 | 6 | 1 | 2 | 6.1 | Fc1ccc(N(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 | 10.1016/s0960-894x(01)00727-2 | ||
44233185 | 193154 | 0 | None | -181 | 4 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 1327 | 29 | 14 | 16 | 1.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL539193 | 193154 | 0 | None | -181 | 4 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 1327 | 29 | 14 | 16 | 1.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL5083565 | 213099 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.1c00793 | ||||
44458789 | 141281 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 1668 | 41 | 14 | 16 | 4.5 | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O | 10.1021/jm00109a034 | ||
CHEMBL386306 | 141281 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 1668 | 41 | 14 | 16 | 4.5 | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O | 10.1021/jm00109a034 | ||
44458351 | 98931 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 443 | 5 | 0 | 2 | 5.9 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL282657 | 98931 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 443 | 5 | 0 | 2 | 5.9 | FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL410808 | 211096 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O | 10.1021/jm00037a009 | ||||
15755314 | 101728 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 711 | 17 | 4 | 9 | 3.4 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL302843 | 101728 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 711 | 17 | 4 | 9 | 3.4 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCCc1ccccc1 | 10.1021/jm00089a011 | ||
44458789 | 141281 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 1668 | 41 | 14 | 16 | 4.5 | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O | 10.1021/jm00085a015 | ||
CHEMBL386306 | 141281 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 1668 | 41 | 14 | 16 | 4.5 | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O | 10.1021/jm00085a015 | ||
18655106 | 198785 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 464 | 10 | 0 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL59854 | 198785 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 464 | 10 | 0 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 | 10.1016/S0960-894X(01)80747-2 | ||
44287443 | 99808 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 528 | 9 | 0 | 5 | 4.9 | CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL288942 | 99808 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 528 | 9 | 0 | 5 | 4.9 | CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
10697072 | 55524 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 511 | 11 | 3 | 5 | 3.8 | COc1ccccc1CNCC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL162288 | 55524 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 511 | 11 | 3 | 5 | 3.8 | COc1ccccc1CNCC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
22901331 | 11876 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
54435601 | 11876 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
59922977 | 11876 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1183068 | 11876 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL278294 | 11876 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
22901331 | 11876 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00085a015 | ||
54435601 | 11876 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00085a015 | ||
59922977 | 11876 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00085a015 | ||
CHEMBL1183068 | 11876 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00085a015 | ||
CHEMBL278294 | 11876 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00085a015 | ||
44318310 | 203945 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 395 | 2 | 1 | 3 | 4.8 | Fc1ccc(C2NCCOC23CCC(c2cccc(C(F)(F)F)c2)CO3)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL81986 | 203945 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 395 | 2 | 1 | 3 | 4.8 | Fc1ccc(C2NCCOC23CCC(c2cccc(C(F)(F)F)c2)CO3)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
44333682 | 4554 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 619 | 6 | 1 | 3 | 7.4 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cc(Br)cc(Br)c2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL102887 | 4554 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 619 | 6 | 1 | 3 | 7.4 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cc(Br)cc(Br)c2)c1 | 10.1016/S0960-894X(96)00563-X | ||
11490127 | 91652 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 580 | 5 | 0 | 2 | 8.1 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CBr)nc2ccccc2c1-c1ccccc1 | 10.1021/jm034219a | ||
CHEMBL24194 | 91652 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 580 | 5 | 0 | 2 | 8.1 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CBr)nc2ccccc2c1-c1ccccc1 | 10.1021/jm034219a | ||
12225557 | 120664 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL357717 | 120664 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 382 | 6 | 1 | 2 | 5.1 | c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81197-5 | ||
24801792 | 87016 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 416 | 5 | 0 | 3 | 5.1 | CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2F)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333644 | 87016 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 416 | 5 | 0 | 3 | 5.1 | CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2F)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
54582296 | 60826 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 486 | 5 | 0 | 2 | 6.8 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)ccnc1CCl | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765498 | 60826 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 486 | 5 | 0 | 2 | 6.8 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)ccnc1CCl | 10.1016/j.bmc.2011.02.031 | ||
10473960 | 85855 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 3.6 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm9700171 | ||
CHEMBL23129 | 85855 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 3.6 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm9700171 | ||
44177570 | 60931 | 0 | None | -169 | 4 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 1219 | 27 | 10 | 10 | 6.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766204 | 60931 | 0 | None | -169 | 4 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 1219 | 27 | 10 | 10 | 6.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
68932301 | 124272 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 594 | 4 | 0 | 4 | 4.9 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL3642169 | 124272 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 594 | 4 | 0 | 4 | 4.9 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
44288795 | 167709 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 467 | 6 | 3 | 5 | 4.7 | O=C(c1cc(O)cc(O)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL43394 | 167709 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 467 | 6 | 3 | 5 | 4.7 | O=C(c1cc(O)cc(O)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
10917690 | 205871 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 471 | 8 | 0 | 5 | 5.4 | COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1021/jm058225d | ||
CHEMBL95051 | 205871 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 471 | 8 | 0 | 5 | 5.4 | COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 | 10.1021/jm058225d | ||
44286718 | 167166 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 437 | 5 | 1 | 1 | 6.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL43027 | 167166 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 437 | 5 | 1 | 1 | 6.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
44383969 | 128524 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.5 | FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00006a012 | ||
CHEMBL367034 | 128524 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.5 | FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00006a012 | ||
44383969 | 128524 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.5 | FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00006a012 | ||
CHEMBL367034 | 128524 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.5 | FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00006a012 | ||
54585202 | 60827 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 536 | 5 | 1 | 4 | 5.8 | Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765499 | 60827 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 536 | 5 | 1 | 4 | 5.8 | Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
54585205 | 60836 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 492 | 4 | 0 | 4 | 6.0 | Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765506 | 60836 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 492 | 4 | 0 | 4 | 6.0 | Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 | 10.1016/j.bmc.2011.02.031 | ||
46884432 | 7840 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 588 | 5 | 0 | 3 | 7.7 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090285 | 7840 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 588 | 5 | 0 | 3 | 7.7 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44297602 | 193572 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 614 | 9 | 1 | 5 | 4.9 | CN(Cc1ccc(Cl)c(Cl)c1)CC(NCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL55098 | 193572 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 614 | 9 | 1 | 5 | 4.9 | CN(Cc1ccc(Cl)c(Cl)c1)CC(NCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL2114442 | 207510 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O | 10.1021/jm00037a009 | ||||
24783683 | 121564 | 0 | None | - | 0 | Mongolian jird | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 455 | 7 | 1 | 3 | 6.2 | COc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596465 | 121564 | 0 | None | - | 0 | Mongolian jird | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 455 | 7 | 1 | 3 | 6.2 | COc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
24889111 | 7842 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 656 | 7 | 1 | 4 | 7.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090287 | 7842 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 656 | 7 | 1 | 4 | 7.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
10370593 | 6186 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 4 | 1 | 3 | 7.5 | Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
CHEMBL108164 | 6186 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 4 | 1 | 3 | 7.5 | Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
44288976 | 162680 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 5.9 | O=C(c1cccc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL418438 | 162680 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 5.9 | O=C(c1cccc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
10349900 | 106267 | 0 | None | 39 | 3 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 716 | 13 | 3 | 7 | 2.8 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144343 | 106267 | 0 | None | 39 | 3 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 716 | 13 | 3 | 7 | 2.8 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
44312887 | 102464 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 626 | 14 | 6 | 6 | 1.4 | C[C@@H](O)C(NC(=O)CC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O | 10.1021/jm00068a003 | ||
CHEMBL306267 | 102464 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 626 | 14 | 6 | 6 | 1.4 | C[C@@H](O)C(NC(=O)CC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O | 10.1021/jm00068a003 | ||
24782658 | 121559 | 0 | None | - | 0 | Mongolian jird | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 475 | 6 | 1 | 2 | 7.4 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2cccc3ccccc23)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596460 | 121559 | 0 | None | - | 0 | Mongolian jird | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 475 | 6 | 1 | 2 | 7.4 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2cccc3ccccc23)c1 | 10.1016/j.bmcl.2015.04.098 | ||
22851562 | 165900 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL42778 | 165900 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
44297451 | 100193 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 567 | 9 | 1 | 5 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3Cl)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL292211 | 100193 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 567 | 9 | 1 | 5 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3Cl)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
16755232 | 173016 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 514 | 4 | 1 | 4 | 6.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cnnc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL453314 | 173016 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 514 | 4 | 1 | 4 | 6.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cnnc12 | 10.1016/j.bmc.2008.05.067 | ||
21308488 | 101033 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 603 | 12 | 1 | 5 | 5.4 | CS(=O)(=O)N(CC1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)c1ccccc1 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL297957 | 101033 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 603 | 12 | 1 | 5 | 5.4 | CS(=O)(=O)N(CC1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)c1ccccc1 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL2369601 | 207890 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O | 10.1021/jm960281e | ||||
10043484 | 89035 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 350 | 6 | 1 | 3 | 4.0 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 | 10.1021/jm9700171 | ||
CHEMBL23715 | 89035 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 350 | 6 | 1 | 3 | 4.0 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 | 10.1021/jm9700171 | ||
44334006 | 107130 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 520 | 6 | 1 | 3 | 6.6 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(CO)(c3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
CHEMBL318989 | 107130 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 520 | 6 | 1 | 3 | 6.6 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(CO)(c3ccccc3)CC2)c2cc(Cl)ccc21 | 10.1016/s0960-894x(01)00616-3 | ||
44297513 | 101134 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 547 | 9 | 1 | 5 | 4.0 | Cc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL298772 | 101134 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 547 | 9 | 1 | 5 | 4.0 | Cc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 | 10.1016/s0960-894x(98)00320-5 | ||
10499624 | 116134 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 337 | 5 | 1 | 2 | 4.8 | CC(C)(C)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
CHEMBL336931 | 116134 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 337 | 5 | 1 | 2 | 4.8 | CC(C)(C)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
44308930 | 202624 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 255 | 5 | 1 | 2 | 3.5 | Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 | 10.1016/S0960-894X(00)80063-3 | ||
CHEMBL71498 | 202624 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 255 | 5 | 1 | 2 | 3.5 | Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 | 10.1016/S0960-894X(00)80063-3 | ||
44308930 | 202624 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 255 | 5 | 1 | 2 | 3.5 | Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL71498 | 202624 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 255 | 5 | 1 | 2 | 3.5 | Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 | 10.1016/0960-894X(95)00476-A | ||
44299916 | 194129 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 387 | 9 | 1 | 2 | 6.0 | Cc1cc(C)cc(COCC(NC(C)C)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL55796 | 194129 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 387 | 9 | 1 | 2 | 6.0 | Cc1cc(C)cc(COCC(NC(C)C)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
9869033 | 99958 | 3 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL290364 | 99958 | 3 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
56675290 | 66116 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 7 | 0 | 4 | 5.2 | COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817884 | 66116 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 7 | 0 | 4 | 5.2 | COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852032 | 66116 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 451 | 7 | 0 | 4 | 5.2 | COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC | 10.1016/j.bmc.2011.07.014 | ||
16755257 | 172814 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 543 | 4 | 0 | 5 | 6.6 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL452794 | 172814 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 543 | 4 | 0 | 5 | 6.6 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 | 10.1016/j.bmc.2008.05.067 | ||
44324532 | 205116 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 578 | 14 | 1 | 4 | 5.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)C)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL90547 | 205116 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 578 | 14 | 1 | 4 | 5.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)C)C1 | 10.1016/S0960-894X(01)80747-2 | ||
15755319 | 100214 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 669 | 15 | 5 | 7 | 3.8 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL292320 | 100214 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 669 | 15 | 5 | 7 | 3.8 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
10410206 | 79174 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 7 | 2 | 3 | 4.9 | Cc1cc(C)cc(COC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm00035a006 | ||
CHEMBL2114308 | 79174 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 7 | 2 | 3 | 4.9 | Cc1cc(C)cc(COC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm00035a006 | ||
10410322 | 98944 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 4.3 | COc1ccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)cc1 | 10.1021/jm00035a006 | ||
CHEMBL282728 | 98944 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 4.3 | COc1ccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)cc1 | 10.1021/jm00035a006 | ||
10043484 | 89035 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 350 | 6 | 1 | 3 | 4.0 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 | 10.1021/jm00035a006 | ||
CHEMBL23715 | 89035 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 350 | 6 | 1 | 3 | 4.0 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 | 10.1021/jm00035a006 | ||
10043484 | 89035 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 350 | 6 | 1 | 3 | 4.0 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 | 10.1021/jm00066a015 | ||
CHEMBL23715 | 89035 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 350 | 6 | 1 | 3 | 4.0 | Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 | 10.1021/jm00066a015 | ||
44297931 | 192112 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 511 | 9 | 1 | 4 | 5.3 | Cc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL52198 | 192112 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 511 | 9 | 1 | 4 | 5.3 | Cc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
44287191 | 157139 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 465 | 6 | 0 | 1 | 6.9 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL40817 | 157139 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 465 | 6 | 0 | 1 | 6.9 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
44275987 | 98885 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80246-2 | ||
CHEMBL282331 | 98885 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80246-2 | ||
19797477 | 38428 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 413 | 7 | 0 | 3 | 5.5 | COc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL146552 | 38428 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 413 | 7 | 0 | 3 | 5.5 | COc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
9984184 | 202943 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 520 | 6 | 2 | 2 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL73618 | 202943 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 520 | 6 | 2 | 2 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00395-3 | ||
44383681 | 165716 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 430 | 6 | 1 | 2 | 6.1 | Clc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80693-9 | ||
CHEMBL426939 | 165716 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 430 | 6 | 1 | 2 | 6.1 | Clc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80693-9 | ||
10411026 | 61027 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 441 | 4 | 2 | 2 | 5.2 | FC(F)(F)c1cc(CN2CCNC(Cc3c[nH]c4ccccc34)C2)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
CHEMBL176772 | 61027 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 441 | 4 | 2 | 2 | 5.2 | FC(F)(F)c1cc(CN2CCNC(Cc3c[nH]c4ccccc34)C2)cc(C(F)(F)F)c1 | 10.1021/jm00006a011 | ||
44319341 | 204174 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 572 | 10 | 1 | 7 | 3.8 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccnc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL83885 | 204174 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 572 | 10 | 1 | 7 | 3.8 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccnc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
44297493 | 162599 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 563 | 10 | 1 | 6 | 3.7 | COc1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL417914 | 162599 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 563 | 10 | 1 | 6 | 3.7 | COc1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 | 10.1016/s0960-894x(98)00320-5 | ||
10620143 | 98805 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 349 | 5 | 1 | 2 | 4.5 | FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
CHEMBL281828 | 98805 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 349 | 5 | 1 | 2 | 4.5 | FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
54582297 | 60834 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 493 | 4 | 0 | 5 | 5.4 | Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765504 | 60834 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 493 | 4 | 0 | 5 | 5.4 | Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 | 10.1016/j.bmc.2011.02.031 | ||
71583092 | 87797 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 5.1 | O=C1CC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CCN1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347703 | 87797 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 5.1 | O=C1CC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CCN1 | 10.1016/j.bmc.2013.02.010 | ||
44324527 | 106056 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 550 | 13 | 2 | 4 | 4.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL314084 | 106056 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 550 | 13 | 2 | 4 | 4.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN)C1 | 10.1016/S0960-894X(01)80747-2 | ||
10620143 | 98805 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 349 | 5 | 1 | 2 | 4.5 | FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm9700171 | ||
CHEMBL281828 | 98805 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 349 | 5 | 1 | 2 | 4.5 | FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm9700171 | ||
44274242 | 98694 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 541 | 6 | 1 | 3 | 7.1 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)cc(Cl)c23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL281149 | 98694 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 541 | 6 | 1 | 3 | 7.1 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)cc(Cl)c23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
10553958 | 100899 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(00)80046-3 | ||
CHEMBL297068 | 100899 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(00)80046-3 | ||
CHEMBL5076397 | 212664 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | O[C@H]1COC[C@H]1N1CC[C@@H](c2cc3nc(Nc4cnn([C@@H]5CC5(F)F)c4Cl)ncc3cc2Cl)[C@H](F)C1 | 10.1021/acs.jmedchem.1c01968 | ||||
10553958 | 100899 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
CHEMBL297068 | 100899 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 519 | 6 | 0 | 2 | 7.5 | FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm9700171 | ||
44297469 | 101311 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 567 | 9 | 1 | 5 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL300005 | 101311 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 567 | 9 | 1 | 5 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44328545 | 205918 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 456 | 6 | 1 | 2 | 6.6 | Clc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL95270 | 205918 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 456 | 6 | 1 | 2 | 6.6 | Clc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL1196922 | 206854 | 0 | None | - | 0 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | None | None | None | N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00089a011 | ||||
CHEMBL558620 | 206854 | 0 | None | - | 0 | Guinea pig | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | None | None | None | N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm00089a011 | ||||
10692651 | 100620 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
CHEMBL294960 | 100620 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1021/jm950654w | ||
44294261 | 79298 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 593 | 7 | 0 | 2 | 9.1 | Fc1ccc(C2CCN([C@H]3CC[C@@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2115454 | 79298 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 593 | 7 | 0 | 2 | 9.1 | Fc1ccc(C2CCN([C@H]3CC[C@@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2112241 | 207484 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | COc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H]([C@@H](C)O)NC2=O)cc1 | 10.1021/jm960281e | ||||
44375315 | 56213 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 628 | 12 | 4 | 8 | 4.2 | CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | ||
CHEMBL163510 | 56213 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 628 | 12 | 4 | 8 | 4.2 | CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | ||
10530317 | 5157 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 532 | 9 | 2 | 3 | 4.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL106239 | 5157 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 532 | 9 | 2 | 3 | 4.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl | 10.1021/jm970499g | ||
44286754 | 162594 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 465 | 7 | 1 | 1 | 6.6 | O=C(NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL417881 | 162594 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 465 | 7 | 1 | 1 | 6.6 | O=C(NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
104974 | 3419 | 27 | None | -1202 | 7 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/0960-894X(96)00148-5 | ||
2111 | 3419 | 27 | None | -1202 | 7 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/0960-894X(96)00148-5 | ||
3481 | 3419 | 27 | None | -1202 | 7 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL308148 | 3419 | 27 | None | -1202 | 7 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/0960-894X(96)00148-5 | ||
DB06660 | 3419 | 27 | None | -1202 | 7 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL2369604 | 207892 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm960281e | ||||
44324531 | 205028 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 565 | 13 | 2 | 4 | 4.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCC(=O)O)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL90035 | 205028 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 565 | 13 | 2 | 4 | 4.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCC(=O)O)C1 | 10.1016/S0960-894X(01)80747-2 | ||
44433803 | 146261 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL392465 | 146261 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 654 | 5 | 0 | 5 | 6.8 | CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 | 10.1016/j.bmcl.2007.08.028 | ||
44289934 | 100789 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 529 | 12 | 2 | 4 | 5.1 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccc(F)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL296216 | 100789 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 529 | 12 | 2 | 4 | 5.1 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccc(F)cc1)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
44358672 | 118853 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 541 | 7 | 0 | 5 | 4.9 | CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Br | 10.1021/jm000986n | ||
CHEMBL344378 | 118853 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 541 | 7 | 0 | 5 | 4.9 | CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Br | 10.1021/jm000986n | ||
21121353 | 101003 | 0 | None | 19 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 625 | 14 | 4 | 7 | 2.0 | CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O | 10.1021/jm00063a015 | ||
CHEMBL297776 | 101003 | 0 | None | 19 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 625 | 14 | 4 | 7 | 2.0 | CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O | 10.1021/jm00063a015 | ||
71452678 | 78167 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 591 | 5 | 2 | 3 | 6.4 | Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL2112211 | 78167 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 591 | 5 | 2 | 3 | 6.4 | Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1016/s0960-894x(02)00382-7 | ||
9868530 | 76979 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 5.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL20837 | 76979 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 5.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
24800398 | 86982 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 450 | 6 | 0 | 3 | 6.1 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CCCC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333610 | 86982 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 450 | 6 | 0 | 3 | 6.1 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CCCC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
56678486 | 66136 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 5 | 0 | 3 | 5.1 | N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817837 | 66136 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 5 | 0 | 3 | 5.1 | N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852157 | 66136 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 5 | 0 | 3 | 5.1 | N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
9874168 | 203991 | 3 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL82386 | 203991 | 3 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/0960-894X(96)00148-5 | ||
44408144 | 74917 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 498 | 4 | 0 | 2 | 6.4 | CN(C)[C@H]1CC[C@](c2ccccc2)(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2=O)CC1 | 10.1016/j.bmcl.2005.11.111 | ||
CHEMBL203700 | 74917 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 498 | 4 | 0 | 2 | 6.4 | CN(C)[C@H]1CC[C@](c2ccccc2)(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2=O)CC1 | 10.1016/j.bmcl.2005.11.111 | ||
44415411 | 138256 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 475 | 5 | 0 | 3 | 6.3 | COC(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL378076 | 138256 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 475 | 5 | 0 | 3 | 6.3 | COC(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
2755911 | 75088 | 48 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 298 | 6 | 2 | 3 | 2.0 | NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1021/ml5002954 | ||
CHEMBL2042018 | 75088 | 48 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 298 | 6 | 2 | 3 | 2.0 | NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1021/ml5002954 | ||
44274104 | 80148 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 571 | 7 | 1 | 5 | 5.9 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCOCC3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL21489 | 80148 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 571 | 7 | 1 | 5 | 5.9 | Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCOCC3)ccc21 | 10.1016/s0960-894x(01)00182-2 | ||
18669089 | 98482 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 509 | 6 | 1 | 3 | 6.7 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)(C)C)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL279523 | 98482 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 509 | 6 | 1 | 3 | 6.7 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)(C)C)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
24799187 | 86998 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 449 | 6 | 0 | 4 | 4.8 | CN1CCC(COCc2cc(C(F)(F)F)cc(N3CC=CC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333626 | 86998 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 449 | 6 | 0 | 4 | 4.8 | CN1CCC(COCc2cc(C(F)(F)F)cc(N3CC=CC3)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
22293526 | 79221 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.4 | O=C(NC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2115008 | 79221 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.4 | O=C(NC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00249-4 | ||
24785443 | 121554 | 0 | None | - | 0 | Mongolian jird | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 425 | 6 | 1 | 2 | 6.2 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596455 | 121554 | 0 | None | - | 0 | Mongolian jird | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 425 | 6 | 1 | 2 | 6.2 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
44338586 | 6807 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 4.9 | COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL108422 | 6807 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 4.9 | COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 | 10.1016/s0960-894x(02)00563-2 | ||
71541577 | 86986 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 6 | 0 | 3 | 5.8 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333614 | 86986 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 6 | 0 | 3 | 5.8 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
46884518 | 7896 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 554 | 5 | 0 | 4 | 6.8 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090547 | 7896 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 554 | 5 | 0 | 4 | 6.8 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44306436 | 100533 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 538 | 8 | 2 | 5 | 3.1 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL294370 | 100533 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 538 | 8 | 2 | 5 | 3.1 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
44335360 | 4796 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 608 | 8 | 2 | 4 | 5.5 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 | 10.1016/s0960-894x(01)00631-x | ||
CHEMBL104348 | 4796 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 608 | 8 | 2 | 4 | 5.5 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 | 10.1016/s0960-894x(01)00631-x | ||
44358427 | 30798 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 643 | 7 | 1 | 3 | 8.0 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL139903 | 30798 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 643 | 7 | 1 | 3 | 8.0 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44325096 | 111044 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 323 | 3 | 1 | 3 | 4.1 | COc1ccccc1[C@H]1COC2(CCCNC2c2ccccc2)C1 | 10.1016/s0960-894x(02)00509-7 | ||
CHEMBL327928 | 111044 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 323 | 3 | 1 | 3 | 4.1 | COc1ccccc1[C@H]1COC2(CCCNC2c2ccccc2)C1 | 10.1016/s0960-894x(02)00509-7 | ||
58993609 | 121563 | 0 | None | - | 0 | Mongolian jird | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 470 | 7 | 1 | 4 | 6.1 | O=[N+]([O-])c1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596464 | 121563 | 0 | None | - | 0 | Mongolian jird | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 470 | 7 | 1 | 4 | 6.1 | O=[N+]([O-])c1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
40727876 | 115693 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 417 | 7 | 3 | 4 | 3.0 | O=C(N[C@@H](Cc1ccccc1)C(=O)NNC(=O)c1ccccc1)OCc1ccccc1 | 10.1021/ml5002954 | ||
CHEMBL3358423 | 115693 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 417 | 7 | 3 | 4 | 3.0 | O=C(N[C@@H](Cc1ccccc1)C(=O)NNC(=O)c1ccccc1)OCc1ccccc1 | 10.1021/ml5002954 | ||
44297642 | 193779 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 567 | 9 | 1 | 5 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL55240 | 193779 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 567 | 9 | 1 | 5 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
53379507 | 66120 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 421 | 6 | 0 | 3 | 5.2 | COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817829 | 66120 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 421 | 6 | 0 | 3 | 5.2 | COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852067 | 66120 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 421 | 6 | 0 | 3 | 5.2 | COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 | 10.1016/j.bmc.2011.07.014 | ||
10390130 | 98784 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 474 | 6 | 2 | 2 | 5.9 | NC(=O)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL281717 | 98784 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 474 | 6 | 2 | 2 | 5.9 | NC(=O)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00220-N | ||
11619202 | 87795 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 5 | 1 | 2 | 6.3 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347697 | 87795 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 5 | 1 | 2 | 6.3 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
107686 | 3327 | 37 | None | 15 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
3522 | 3327 | 37 | None | 15 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
CHEMBL131171 | 3327 | 37 | None | 15 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
44299943 | 193889 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 359 | 8 | 1 | 2 | 5.2 | CNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL55476 | 193889 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 359 | 8 | 1 | 2 | 5.2 | CNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
10602065 | 35170 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 521 | 8 | 0 | 2 | 7.5 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(CCc3ccccc3)CC2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
CHEMBL143775 | 35170 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 521 | 8 | 0 | 2 | 7.5 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(CCc3ccccc3)CC2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
44358670 | 29758 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 545 | 7 | 1 | 5 | 4.9 | CC(C)N1CCN(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 | 10.1021/jm000986n | ||
CHEMBL138853 | 29758 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 545 | 7 | 1 | 5 | 4.9 | CC(C)N1CCN(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 | 10.1021/jm000986n | ||
44297463 | 162569 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 611 | 9 | 1 | 5 | 4.5 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Br)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL417731 | 162569 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 611 | 9 | 1 | 5 | 4.5 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Br)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
10327540 | 162953 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 720 | 21 | 2 | 7 | 7.5 | CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 | 10.1021/jm960281e | ||
CHEMBL420221 | 162953 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 720 | 21 | 2 | 7 | 7.5 | CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 | 10.1021/jm960281e | ||
44289219 | 161753 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 6 | 1 | 2 | 5.6 | O=C(Cc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL416436 | 161753 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 6 | 1 | 2 | 5.6 | O=C(Cc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
118722857 | 115691 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 376 | 7 | 2 | 5 | 1.6 | CS(=O)(=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1021/ml5002954 | ||
CHEMBL3358421 | 115691 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 376 | 7 | 2 | 5 | 1.6 | CS(=O)(=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1021/ml5002954 | ||
44333606 | 5080 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 7.2 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2Cl)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL105800 | 5080 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 7.2 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2Cl)c1 | 10.1016/S0960-894X(96)00563-X | ||
10342797 | 90458 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 432 | 7 | 2 | 3 | 4.9 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1Cl)c1ccccc1 | 10.1021/jm00035a006 | ||
CHEMBL23927 | 90458 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 432 | 7 | 2 | 3 | 4.9 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1Cl)c1ccccc1 | 10.1021/jm00035a006 | ||
24800925 | 87017 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 360 | 5 | 1 | 3 | 3.7 | Brc1cncc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333645 | 87017 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 360 | 5 | 1 | 3 | 3.7 | Brc1cncc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL405795 | 210834 | 6 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | None | None | None | NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a011 | ||||
10458786 | 5351 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 504 | 5 | 0 | 3 | 6.9 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL107283 | 5351 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 504 | 5 | 0 | 3 | 6.9 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
44288934 | 154552 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 599 | 6 | 0 | 3 | 7.3 | O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL40189 | 154552 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 599 | 6 | 0 | 3 | 7.3 | O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
10087358 | 60021 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 320 | 4 | 1 | 3 | 3.3 | O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 | 10.1021/jm00006a011 | ||
CHEMBL174465 | 60021 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 320 | 4 | 1 | 3 | 3.3 | O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 | 10.1021/jm00006a011 | ||
21308490 | 101177 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 522 | 8 | 1 | 3 | 6.2 | O=C([C@H](COCc1ccc(Cl)c(Cl)c1)NCc1ccccc1)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL299089 | 101177 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 522 | 8 | 1 | 3 | 6.2 | O=C([C@H](COCc1ccc(Cl)c(Cl)c1)NCc1ccccc1)N1CCC2(CCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00319-9 | ||
44346675 | 113756 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 320 | 4 | 1 | 3 | 3.3 | O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL333039 | 113756 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 320 | 4 | 1 | 3 | 3.3 | O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 | 10.1021/jm9700171 | ||
44337704 | 167571 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 578 | 9 | 3 | 5 | 4.9 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=N)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
CHEMBL432979 | 167571 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 578 | 9 | 3 | 5 | 4.9 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=N)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
44297859 | 101247 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 603 | 11 | 1 | 5 | 5.5 | CN(c1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)S(C)(=O)=O | 10.1016/s0960-894x(98)00319-9 | ||
CHEMBL299528 | 101247 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 603 | 11 | 1 | 5 | 5.5 | CN(c1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)S(C)(=O)=O | 10.1016/s0960-894x(98)00319-9 | ||
21994329 | 28708 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 463 | 8 | 1 | 4 | 4.7 | COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL137972 | 28708 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 463 | 8 | 1 | 4 | 4.7 | COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL2112246 | 207489 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm000316h | ||||
11724403 | 167980 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL435564 | 167980 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 | 10.1016/0960-894X(95)00205-8 | ||
10389807 | 96162 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 466 | 7 | 2 | 3 | 5.3 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1021/jm00035a006 | ||
CHEMBL26336 | 96162 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 466 | 7 | 2 | 3 | 5.3 | O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1021/jm00035a006 | ||
CHEMBL411230 | 211127 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O | 10.1021/jm00037a009 | ||||
44433785 | 146376 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 526 | 6 | 0 | 2 | 7.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(CC2CCCCC2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL392566 | 146376 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 526 | 6 | 0 | 2 | 7.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(CC2CCCCC2)C[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2007.08.028 | ||
68870858 | 124271 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 5.6 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL3642168 | 124271 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 5.6 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
18391053 | 166026 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 487 | 5 | 2 | 3 | 4.0 | NCC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL42800 | 166026 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 487 | 5 | 2 | 3 | 4.0 | NCC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
19797458 | 34003 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 417 | 6 | 0 | 2 | 6.2 | Clc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL142638 | 34003 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 417 | 6 | 0 | 2 | 6.2 | Clc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
19797415 | 38007 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 475 | 8 | 0 | 3 | 7.3 | c1ccc(Oc2cccc(COC3C4CCN(CC4)C3C(c3ccccc3)c3ccccc3)c2)cc1 | 10.1021/jm00024a007 | ||
CHEMBL146223 | 38007 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 475 | 8 | 0 | 3 | 7.3 | c1ccc(Oc2cccc(COC3C4CCN(CC4)C3C(c3ccccc3)c3ccccc3)c2)cc1 | 10.1021/jm00024a007 | ||
44287481 | 162432 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 479 | 8 | 1 | 1 | 7.0 | O=C(CC(c1ccccc1)c1ccccc1)NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL417522 | 162432 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 479 | 8 | 1 | 1 | 7.0 | O=C(CC(c1ccccc1)c1ccccc1)NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(96)00280-6 | ||
10650263 | 25882 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 547 | 4 | 0 | 4 | 6.8 | Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
CHEMBL135572 | 25882 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 547 | 4 | 0 | 4 | 6.8 | Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm980042m | ||
44345147 | 110811 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 478 | 5 | 1 | 2 | 7.4 | Cc1cc(C)cc(/C(F)=C2\CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
CHEMBL326613 | 110811 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 478 | 5 | 1 | 2 | 7.4 | Cc1cc(C)cc(/C(F)=C2\CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
44297649 | 188126 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 649 | 9 | 1 | 6 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL50455 | 188126 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 649 | 9 | 1 | 6 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
10052114 | 165530 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 512 | 4 | 2 | 3 | 4.9 | CNC(=O)N1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 | 10.1021/jm00006a011 | ||
CHEMBL425848 | 165530 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 512 | 4 | 2 | 3 | 4.9 | CNC(=O)N1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 | 10.1021/jm00006a011 | ||
10837320 | 35219 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 5 | 1 | 1 | 6.4 | FC(F)(F)c1cc(CCCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
CHEMBL143813 | 35219 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 5 | 1 | 1 | 6.4 | FC(F)(F)c1cc(CCCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
CHEMBL265573 | 208909 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C\c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O | 10.1021/jm00037a009 | ||||
44384901 | 169337 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 579 | 8 | 1 | 4 | 5.7 | COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL444086 | 169337 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 579 | 8 | 1 | 4 | 5.7 | COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 | 10.1016/0960-894X(96)00148-5 | ||
44384986 | 129252 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 623 | 9 | 1 | 5 | 6.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL367528 | 129252 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 623 | 9 | 1 | 5 | 6.0 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C | 10.1016/0960-894X(96)00148-5 | ||
44411637 | 138750 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 441 | 4 | 1 | 3 | 4.5 | O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F | 10.1016/j.bmcl.2006.02.027 | ||
CHEMBL379097 | 138750 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 441 | 4 | 1 | 3 | 4.5 | O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F | 10.1016/j.bmcl.2006.02.027 | ||
44344195 | 162808 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 475 | 5 | 1 | 3 | 6.2 | Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 | 10.1016/S0960-894X(96)00623-3 | ||
CHEMBL419232 | 162808 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 475 | 5 | 1 | 3 | 6.2 | Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 | 10.1016/S0960-894X(96)00623-3 | ||
10055415 | 106274 | 0 | None | - | 3 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 688 | 12 | 4 | 5 | 3.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144352 | 106274 | 0 | None | - | 3 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 688 | 12 | 4 | 5 | 3.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL418757 | 211491 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm9800346 | ||||
58993550 | 121552 | 0 | None | - | 0 | Mongolian jird | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 431 | 6 | 1 | 6 | 3.7 | Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596453 | 121552 | 0 | None | - | 0 | Mongolian jird | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 431 | 6 | 1 | 6 | 3.7 | Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
44384677 | 130936 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 667 | 11 | 1 | 6 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL369174 | 130936 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 667 | 11 | 1 | 6 | 6.5 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C | 10.1016/0960-894X(96)00148-5 | ||
44413144 | 138689 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 465 | 8 | 2 | 3 | 4.4 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.04.045 | ||
CHEMBL378784 | 138689 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 465 | 8 | 2 | 3 | 4.4 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1016/j.bmcl.2006.04.045 | ||
54582277 | 60819 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 438 | 4 | 1 | 2 | 6.0 | Cc1nccc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765491 | 60819 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 438 | 4 | 1 | 2 | 6.0 | Cc1nccc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
28558057 | 162499 | 2 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 423 | 4 | 1 | 1 | 6.5 | O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
CHEMBL41762 | 162499 | 2 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 423 | 4 | 1 | 1 | 6.5 | O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(96)00280-6 | ||
24801627 | 86988 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 398 | 5 | 0 | 3 | 4.9 | CN1CCC(COCc2cc(Cl)cc(C(F)(F)F)n2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333616 | 86988 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 398 | 5 | 0 | 3 | 4.9 | CN1CCC(COCc2cc(Cl)cc(C(F)(F)F)n2)(c2ccccc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
10695397 | 189014 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 463 | 6 | 1 | 4 | 4.7 | O=C(O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1021/jm950654w | ||
CHEMBL51477 | 189014 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 463 | 6 | 1 | 4 | 4.7 | O=C(O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1021/jm950654w | ||
46884517 | 8008 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 643 | 7 | 0 | 4 | 8.0 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1091341 | 8008 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 643 | 7 | 0 | 4 | 8.0 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
10026200 | 4779 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 5 | 1 | 3 | 5.9 | CCN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL104277 | 4779 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 5 | 1 | 3 | 5.9 | CCN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C | 10.1021/jm00016a014 | ||
44385575 | 59484 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 653 | 11 | 1 | 6 | 5.6 | COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL172676 | 59484 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 653 | 11 | 1 | 6 | 5.6 | COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/0960-894X(96)00148-5 | ||
71583203 | 87793 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 445 | 5 | 0 | 2 | 6.3 | CN1CCCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347695 | 87793 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 445 | 5 | 0 | 2 | 6.3 | CN1CCCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmc.2013.02.010 | ||
10473960 | 85855 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 3.6 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00006a012 | ||
CHEMBL23129 | 85855 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 3.6 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00006a012 | ||
10473960 | 85855 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 3.6 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
CHEMBL23129 | 85855 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 3.6 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
44415423 | 138724 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 5 | 1 | 2 | 5.9 | O=C(O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL378984 | 138724 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 5 | 1 | 2 | 5.9 | O=C(O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
71699787 | 124260 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 593 | 4 | 0 | 3 | 5.5 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL3642157 | 124260 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 593 | 4 | 0 | 3 | 5.5 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
19797468 | 37523 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.5 | FC(F)(F)c1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
CHEMBL145801 | 37523 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.5 | FC(F)(F)c1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
19003156 | 66805 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 3.6 | CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm0311487 | ||
CHEMBL187554 | 66805 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 3.6 | CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm0311487 | ||
10473960 | 85855 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 3.6 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00066a015 | ||
CHEMBL23129 | 85855 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 3.6 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00066a015 | ||
15639109 | 163482 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 6 | 1 | 2 | 5.6 | c1ccc(CN[C@H]2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
CHEMBL420876 | 163482 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 6 | 1 | 2 | 5.6 | c1ccc(CN[C@H]2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
44321046 | 204499 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 411 | 7 | 2 | 3 | 5.1 | CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL86643 | 204499 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 411 | 7 | 2 | 3 | 5.1 | CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
44321046 | 204499 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 411 | 7 | 2 | 3 | 5.1 | CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
CHEMBL86643 | 204499 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 411 | 7 | 2 | 3 | 5.1 | CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00092a009 | ||
44321493 | 204516 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 7 | 1 | 3 | 6.4 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 | 10.1021/jm00092a009 | ||
CHEMBL86746 | 204516 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 7 | 1 | 3 | 6.4 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 | 10.1021/jm00092a009 | ||
10451098 | 11701 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 359 | 4 | 2 | 1 | 4.5 | O=C(NCc1c[nH]c2ccccc12)N1C2CCC(C2)C1Cc1ccccc1 | 10.1016/S0960-894X(96)00570-7 | ||
CHEMBL118194 | 11701 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 359 | 4 | 2 | 1 | 4.5 | O=C(NCc1c[nH]c2ccccc12)N1C2CCC(C2)C1Cc1ccccc1 | 10.1016/S0960-894X(96)00570-7 | ||
44307137 | 101641 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 4 | 0 | 4 | 5.1 | COC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL302315 | 101641 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 4 | 0 | 4 | 5.1 | COC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
24783930 | 121560 | 0 | None | - | 0 | Mongolian jird | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 6.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2Cl)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596461 | 121560 | 0 | None | - | 0 | Mongolian jird | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 6.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2Cl)c1 | 10.1016/j.bmcl.2015.04.098 | ||
10030004 | 110857 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 532 | 5 | 0 | 3 | 6.4 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL326889 | 110857 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 532 | 5 | 0 | 3 | 6.4 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
15391369 | 102355 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 518 | 6 | 2 | 2 | 5.5 | CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL305509 | 102355 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 518 | 6 | 2 | 2 | 5.5 | CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 | 10.1016/s0960-894x(98)00395-3 | ||
44328389 | 106753 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 6 | 1 | 2 | 5.6 | c1ccc(CNC2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00044a002 | ||
CHEMBL316842 | 106753 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 6 | 1 | 2 | 5.6 | c1ccc(CNC2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00044a002 | ||
4189 | 205195 | 91 | None | -27 | 34 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
CHEMBL1559 | 205195 | 91 | None | -27 | 34 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
CHEMBL91 | 205195 | 91 | None | -27 | 34 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
10405461 | 60020 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 348 | 4 | 1 | 3 | 3.9 | Cc1cc(C)cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)c1 | 10.1021/jm00006a011 | ||
CHEMBL174464 | 60020 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 348 | 4 | 1 | 3 | 3.9 | Cc1cc(C)cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)c1 | 10.1021/jm00006a011 | ||
2090 | 2726 | 20 | None | - | 4 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
5311312 | 2726 | 20 | None | - | 4 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
CHEMBL437797 | 2726 | 20 | None | - | 4 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)81197-5 | ||||
44384987 | 61025 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 609 | 9 | 1 | 5 | 5.7 | COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL176769 | 61025 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 609 | 9 | 1 | 5 | 5.7 | COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/0960-894X(96)00148-5 | ||
44289169 | 101018 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL297883 | 101018 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
54585204 | 60835 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 478 | 4 | 1 | 4 | 5.7 | Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765505 | 60835 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 478 | 4 | 1 | 4 | 5.7 | Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 | 10.1016/j.bmc.2011.02.031 | ||
10031310 | 4642 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 589 | 6 | 1 | 3 | 6.5 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(I)cc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL103510 | 4642 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 589 | 6 | 1 | 3 | 6.5 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(I)cc2)c1 | 10.1016/S0960-894X(96)00563-X | ||
10339539 | 109280 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 377 | 5 | 1 | 2 | 5.3 | CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL323128 | 109280 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 377 | 5 | 1 | 2 | 5.3 | CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
44276788 | 96049 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 550 | 8 | 1 | 3 | 7.3 | O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1ccncc1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL26251 | 96049 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 550 | 8 | 1 | 3 | 7.3 | O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1ccncc1 | 10.1016/0960-894X(95)00220-N | ||
44319329 | 204254 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 389 | 4 | 1 | 2 | 5.3 | FC(F)(F)c1cc(CO[C@H]2CCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80280-8 | ||
CHEMBL84588 | 204254 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 389 | 4 | 1 | 2 | 5.3 | FC(F)(F)c1cc(CO[C@H]2CCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80280-8 | ||
44306045 | 100200 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 9 | 2 | 7 | 3.0 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL292256 | 100200 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 9 | 2 | 7 | 3.0 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
9871754 | 5337 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm00016a014 | ||
CHEMBL107172 | 5337 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 533 | 4 | 0 | 4 | 6.2 | Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 | 10.1021/jm00016a014 | ||
21994328 | 30993 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 571 | 8 | 1 | 4 | 6.1 | COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL140086 | 30993 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 571 | 8 | 1 | 4 | 6.1 | COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
24784190 | 121571 | 0 | None | - | 0 | Mongolian jird | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 469 | 6 | 1 | 4 | 5.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3c(c2)OCO3)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596472 | 121571 | 0 | None | - | 0 | Mongolian jird | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 469 | 6 | 1 | 4 | 5.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3c(c2)OCO3)c1 | 10.1016/j.bmcl.2015.04.098 | ||
9855000 | 20421 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 559 | 3 | 0 | 4 | 6.8 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
CHEMBL130834 | 20421 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 559 | 3 | 0 | 4 | 6.8 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
44328400 | 107625 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 442 | 6 | 1 | 2 | 6.3 | Clc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL319559 | 107625 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 442 | 6 | 1 | 2 | 6.3 | Clc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
44415435 | 79731 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 5.3 | NC(=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL213359 | 79731 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 5.3 | NC(=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
44415469 | 166876 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.8 | CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL429715 | 166876 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.8 | CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
11546759 | 87805 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 445 | 5 | 0 | 2 | 6.3 | CN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347855 | 87805 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 445 | 5 | 0 | 2 | 6.3 | CN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 | 10.1016/j.bmc.2013.02.010 | ||
21994352 | 118776 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 605 | 8 | 1 | 4 | 5.9 | COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2Cc3ccccc3C2)CC1 | 10.1021/jm000986n | ||
CHEMBL343797 | 118776 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 605 | 8 | 1 | 4 | 5.9 | COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2Cc3ccccc3C2)CC1 | 10.1021/jm000986n | ||
10626865 | 57219 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 569 | 11 | 2 | 5 | 4.8 | CSc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL166178 | 57219 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 569 | 11 | 2 | 5 | 4.8 | CSc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
44328424 | 106824 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 454 | 7 | 1 | 4 | 5.2 | COc1ccccc1CNC1C2CC3CCOC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
CHEMBL317297 | 106824 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 454 | 7 | 1 | 4 | 5.2 | COc1ccccc1CNC1C2CC3CCOC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00044a002 | ||
46227360 | 200895 | 0 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL611924 | 200895 | 0 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
10839068 | 118219 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 499 | 7 | 0 | 5 | 5.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3ncon3)CC2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
CHEMBL341745 | 118219 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 499 | 7 | 0 | 5 | 5.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3ncon3)CC2)cc(C(F)(F)F)c1 | 10.1021/jm980376b | ||
24993312 | 178773 | 10 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 475 | 4 | 1 | 2 | 6.7 | C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
CHEMBL473680 | 178773 | 10 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 475 | 4 | 1 | 2 | 6.7 | C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
10436850 | 79236 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 524 | 8 | 3 | 4 | 3.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL2115107 | 79236 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 524 | 8 | 3 | 4 | 3.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
11546190 | 105320 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.7 | N[C@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126960 | 105320 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.7 | N[C@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
19098236 | 33811 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 525 | 6 | 0 | 2 | 8.1 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)C2CCCCC2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
CHEMBL142477 | 33811 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 525 | 6 | 0 | 2 | 8.1 | FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)C2CCCCC2)cc(C(F)(F)F)c1 | 10.1021/jm00024a007 | ||
44319082 | 167464 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 752 | 13 | 1 | 8 | 5.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL432183 | 167464 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 752 | 13 | 1 | 8 | 5.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
18669085 | 82963 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 529 | 7 | 1 | 3 | 7.1 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(-c4ccccc4)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21939 | 82963 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 529 | 7 | 1 | 3 | 7.1 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(-c4ccccc4)cc3)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
44306693 | 101878 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 568 | 9 | 2 | 6 | 3.1 | COc1ccc(C[C@@H](NC(=O)C2C[C@@H](O)CN2C(=O)c2cn(C)c3ccccc23)C(=O)N(C)Cc2ccccc2)cc1 | 10.1021/jm00039a022 | ||
CHEMBL303750 | 101878 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 568 | 9 | 2 | 6 | 3.1 | COc1ccc(C[C@@H](NC(=O)C2C[C@@H](O)CN2C(=O)c2cn(C)c3ccccc23)C(=O)N(C)Cc2ccccc2)cc1 | 10.1021/jm00039a022 | ||
44358476 | 30149 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 6.1 | COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC | 10.1021/jm000986n | ||
CHEMBL139190 | 30149 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 6.1 | COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC | 10.1021/jm000986n | ||
44297629 | 189916 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 567 | 9 | 1 | 5 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL51794 | 189916 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 567 | 9 | 1 | 5 | 4.4 | CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
46884515 | 7743 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 553 | 5 | 1 | 3 | 6.5 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089532 | 7743 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 553 | 5 | 1 | 3 | 6.5 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44456866 | 157427 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 533 | 5 | 1 | 4 | 6.6 | C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
CHEMBL408484 | 157427 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 533 | 5 | 1 | 4 | 6.6 | C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2007.11.081 | ||
24993955 | 183723 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 517 | 4 | 0 | 2 | 7.0 | CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 | 10.1021/jm8016514 | ||
CHEMBL484134 | 183723 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 517 | 4 | 0 | 2 | 7.0 | CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 | 10.1021/jm8016514 | ||
CHEMBL276294 | 209083 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)S(C)(=O)=O)C(N)=O | 10.1021/jm00037a009 | ||||
44415447 | 141020 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.5 | N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL384796 | 141020 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 403 | 4 | 1 | 2 | 5.5 | N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
44338640 | 167526 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 482 | 7 | 1 | 4 | 4.4 | COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 | 10.1016/s0960-894x(02)00563-2 | ||
CHEMBL432627 | 167526 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 482 | 7 | 1 | 4 | 4.4 | COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 | 10.1016/s0960-894x(02)00563-2 | ||
44321099 | 204503 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 426 | 7 | 0 | 3 | 5.4 | COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL86659 | 204503 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 426 | 7 | 0 | 3 | 5.4 | COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
44368159 | 47930 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 459 | 8 | 1 | 5 | 4.6 | CN(Cc1nn[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL155218 | 47930 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 459 | 8 | 1 | 5 | 4.6 | CN(Cc1nn[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
44346420 | 14190 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 473 | 5 | 0 | 3 | 4.8 | COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] | 10.1016/S0960-894X(01)80177-3 | ||
CHEMBL119990 | 14190 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 473 | 5 | 0 | 3 | 4.8 | COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] | 10.1016/S0960-894X(01)80177-3 | ||
44288758 | 100642 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL295122 | 100642 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.9 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
24785191 | 121557 | 0 | None | - | 0 | Mongolian jird | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 6 | 1 | 4 | 5.7 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nccs2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596458 | 121557 | 0 | None | - | 0 | Mongolian jird | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 6 | 1 | 4 | 5.7 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nccs2)c1 | 10.1016/j.bmcl.2015.04.098 | ||
44294423 | 11934 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 414 | 4 | 0 | 5 | 5.0 | CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
53817703 | 11934 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 414 | 4 | 0 | 5 | 5.0 | CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1183414 | 11934 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 414 | 4 | 0 | 5 | 5.0 | CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL295686 | 11934 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 414 | 4 | 0 | 5 | 5.0 | CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
15037919 | 119122 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 396 | 6 | 1 | 2 | 5.4 | Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL346633 | 119122 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 396 | 6 | 1 | 2 | 5.4 | Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
71541376 | 87002 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 382 | 5 | 0 | 3 | 4.4 | CN1CCC(COCc2cc(C(F)(F)F)ccn2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333630 | 87002 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 382 | 5 | 0 | 3 | 4.4 | CN1CCC(COCc2cc(C(F)(F)F)ccn2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
24785445 | 121550 | 0 | None | - | 0 | Mongolian jird | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 4.5 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-n2nnnc2C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596451 | 121550 | 0 | None | - | 0 | Mongolian jird | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 4.5 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-n2nnnc2C(F)(F)F)c1 | 10.1016/j.bmcl.2015.04.098 | ||
10668476 | 98989 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 5.1 | c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80349-2 | ||
CHEMBL282996 | 98989 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 5.1 | c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80349-2 | ||
9957036 | 163606 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 485 | 6 | 1 | 3 | 6.4 | O=C(c1ccc2ccccc2c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL42103 | 163606 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 485 | 6 | 1 | 3 | 6.4 | O=C(c1ccc2ccccc2c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 | 10.1016/0960-894X(96)00287-9 | ||
10668476 | 98989 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 5.1 | c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
CHEMBL282996 | 98989 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 396 | 7 | 1 | 2 | 5.1 | c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
44380709 | 119888 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.6 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL353416 | 119888 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.6 | COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)80859-3 | ||
44297359 | 191749 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 563 | 10 | 1 | 6 | 3.7 | COc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL52070 | 191749 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 563 | 10 | 1 | 6 | 3.7 | COc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 | 10.1016/s0960-894x(98)00320-5 | ||
44345156 | 113608 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 478 | 5 | 1 | 2 | 7.4 | Cc1cc(C)cc(/C(F)=C2/CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
CHEMBL332759 | 113608 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 478 | 5 | 1 | 2 | 7.4 | Cc1cc(C)cc(/C(F)=C2/CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 | 10.1016/S0960-894X(96)00624-5 | ||
10674743 | 109729 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 579 | 9 | 2 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
CHEMBL323762 | 109729 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 579 | 9 | 2 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
100951644 | 169067 | 11 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 411 | 7 | 2 | 9 | 2.3 | CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1 | 10.1021/acs.jmedchem.9b00260 | ||
CHEMBL4437106 | 169067 | 11 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 411 | 7 | 2 | 9 | 2.3 | CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1 | 10.1021/acs.jmedchem.9b00260 | ||
24889283 | 8346 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 597 | 6 | 0 | 5 | 7.3 | CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1093595 | 8346 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 597 | 6 | 0 | 5 | 7.3 | CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 | 10.1016/j.bmcl.2010.01.120 | ||
44289218 | 163157 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 481 | 5 | 2 | 2 | 6.0 | O=C(Nc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL42050 | 163157 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 481 | 5 | 2 | 2 | 6.0 | O=C(Nc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 | 10.1016/0960-894X(96)00287-9 | ||
44233184 | 193100 | 0 | None | -12 | 4 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 1343 | 32 | 15 | 16 | 1.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL538131 | 193100 | 0 | None | -12 | 4 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 1343 | 32 | 15 | 16 | 1.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
15037920 | 45473 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 430 | 7 | 1 | 2 | 5.8 | Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL153042 | 45473 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 430 | 7 | 1 | 2 | 5.8 | Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
44363017 | 37071 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 409 | 4 | 0 | 5 | 5.7 | CCN1/C(=C/C=C/c2nc3nc4ccccc4nc3n2CC)C(C)(C)c2ccccc21 | 10.1021/jm00024a007 | ||
CHEMBL145407 | 37071 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 409 | 4 | 0 | 5 | 5.7 | CCN1/C(=C/C=C/c2nc3nc4ccccc4nc3n2CC)C(C)(C)c2ccccc21 | 10.1021/jm00024a007 | ||
44358982 | 30450 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 548 | 10 | 4 | 5 | 4.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NS(C)(=O)=O)c1)c1ccccc1 | 10.1021/jm00022a010 | ||
CHEMBL139464 | 30450 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 548 | 10 | 4 | 5 | 4.6 | C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NS(C)(=O)=O)c1)c1ccccc1 | 10.1021/jm00022a010 | ||
42639649 | 170178 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 553 | 5 | 0 | 4 | 7.4 | C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
CHEMBL445239 | 170178 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 553 | 5 | 0 | 4 | 7.4 | C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm8016514 | ||
44370352 | 51219 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 683 | 18 | 1 | 5 | 7.5 | CCCCCN(CCCCC)C(=O)[C@@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL158255 | 51219 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 683 | 18 | 1 | 5 | 7.5 | CCCCCN(CCCCC)C(=O)[C@@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 | 10.1016/0960-894X(95)00080-D | ||
44212282 | 60958 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 579 | 8 | 1 | 4 | 5.7 | COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/0960-894X(96)00148-5 | ||
CHEMBL176682 | 60958 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 579 | 8 | 1 | 4 | 5.7 | COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/0960-894X(96)00148-5 | ||
19960248 | 169517 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 349 | 5 | 1 | 2 | 4.5 | FC(F)(F)c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 | 10.1021/jm980376b | ||
CHEMBL444339 | 169517 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 349 | 5 | 1 | 2 | 4.5 | FC(F)(F)c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 | 10.1021/jm980376b | ||
10452352 | 128003 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 380 | 6 | 1 | 5 | 3.3 | COc1cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)cc(OC)c1 | 10.1021/jm00006a011 | ||
CHEMBL366753 | 128003 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 380 | 6 | 1 | 5 | 3.3 | COc1cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)cc(OC)c1 | 10.1021/jm00006a011 | ||
76336391 | 105325 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 471 | 7 | 1 | 2 | 6.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)CC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126965 | 105325 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 471 | 7 | 1 | 2 | 6.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)CC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
71541372 | 87020 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 384 | 5 | 1 | 3 | 4.6 | FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333648 | 87020 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 384 | 5 | 1 | 3 | 4.6 | FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
11634999 | 87789 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 521 | 7 | 0 | 2 | 7.9 | FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2347691 | 87789 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 521 | 7 | 0 | 2 | 7.9 | FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.02.010 | ||
131871 | 119023 | 6 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 450 | 6 | 1 | 2 | 6.1 | FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL345711 | 119023 | 6 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 450 | 6 | 1 | 2 | 6.1 | FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
44359010 | 29785 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 512 | 9 | 4 | 4 | 5.2 | CC(=O)Nc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/jm00022a010 | ||
CHEMBL138883 | 29785 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 512 | 9 | 4 | 4 | 5.2 | CC(=O)Nc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/jm00022a010 | ||
23294208 | 96700 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 590 | 8 | 1 | 4 | 6.8 | O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1016/s0960-894x(98)00215-7 | ||
CHEMBL26790 | 96700 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 590 | 8 | 1 | 4 | 6.8 | O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1016/s0960-894x(98)00215-7 | ||
44299310 | 96287 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 351 | 7 | 1 | 2 | 5.0 | NC(COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL264376 | 96287 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 351 | 7 | 1 | 2 | 5.0 | NC(COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL436706 | 211938 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)C(N)=O | 10.1016/S0960-894X(01)80229-8 | ||||
44346497 | 14374 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 351 | 7 | 1 | 2 | 5.0 | N[C@H](COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
CHEMBL120286 | 14374 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 351 | 7 | 1 | 2 | 5.0 | N[C@H](COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 | 10.1021/jm9700171 | ||
10407632 | 101354 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 383 | 6 | 0 | 2 | 5.5 | c1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
CHEMBL30029 | 101354 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 383 | 6 | 0 | 2 | 5.5 | c1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9700171 | ||
10736544 | 102282 | 2 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 349 | 6 | 2 | 2 | 2.9 | CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 | 10.1016/S0960-894X(97)00353-3 | ||
CHEMBL305094 | 102282 | 2 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 349 | 6 | 2 | 2 | 2.9 | CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 | 10.1016/S0960-894X(97)00353-3 | ||
10520658 | 98194 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL277260 | 98194 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 | 10.1016/0960-894X(95)00205-8 | ||
10025594 | 90459 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 4.3 | COc1cccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm00035a006 | ||
CHEMBL23928 | 90459 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 4.3 | COc1cccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 | 10.1021/jm00035a006 | ||
24799365 | 86991 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 425 | 7 | 1 | 4 | 4.9 | CCNc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333619 | 86991 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 425 | 7 | 1 | 4 | 4.9 | CCNc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
9852376 | 98645 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 639 | 8 | 0 | 4 | 6.6 | CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00215-7 | ||
CHEMBL280789 | 98645 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 639 | 8 | 0 | 4 | 6.6 | CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00215-7 | ||
44385121 | 60840 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 350 | 7 | 2 | 2 | 4.0 | CC(=O)N[C@H](COCc1cc(C)cc(C)c1)Cc1c[nH]c2ccccc12 | 10.1021/jm00006a012 | ||
CHEMBL176557 | 60840 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 350 | 7 | 2 | 2 | 4.0 | CC(=O)N[C@H](COCc1cc(C)cc(C)c1)Cc1c[nH]c2ccccc12 | 10.1021/jm00006a012 | ||
44299753 | 193969 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 443 | 7 | 1 | 2 | 5.0 | NC(COCc1cccc(I)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL55635 | 193969 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 443 | 7 | 1 | 2 | 5.0 | NC(COCc1cccc(I)c1)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80531-X | ||
44287861 | 161190 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 472 | 5 | 1 | 4 | 4.4 | CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL41375 | 161190 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 472 | 5 | 1 | 4 | 4.4 | CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL415600 | 211446 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O | 10.1021/jm00037a009 | ||||
56661421 | 66115 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 421 | 6 | 0 | 3 | 5.2 | COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817831 | 66115 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 421 | 6 | 0 | 3 | 5.2 | COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852028 | 66115 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 421 | 6 | 0 | 3 | 5.2 | COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 | 10.1016/j.bmc.2011.07.014 | ||
44312000 | 202973 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 551 | 8 | 3 | 3 | 4.6 | CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL73839 | 202973 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 551 | 8 | 3 | 3 | 4.6 | CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 | 10.1016/s0960-894x(98)00395-3 | ||
14999557 | 102152 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 697 | 16 | 4 | 9 | 3.3 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL304246 | 102152 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 697 | 16 | 4 | 9 | 3.3 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
68870105 | 124267 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 4 | 0 | 3 | 5.4 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL3642164 | 124267 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 4 | 0 | 3 | 5.4 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
16755281 | 176225 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 439 | 6 | 1 | 7 | 3.9 | COc1cc(CNC(=O)c2c(-c3ccccc3)c3ccccc3n3nnnc23)cc(OC)c1 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL460684 | 176225 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 439 | 6 | 1 | 7 | 3.9 | COc1cc(CNC(=O)c2c(-c3ccccc3)c3ccccc3n3nnnc23)cc(OC)c1 | 10.1016/j.bmc.2008.05.067 | ||
44297698 | 193320 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cc(Cl)cc(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL54717 | 193320 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cc(Cl)cc(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
68932311 | 124273 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 565 | 5 | 1 | 4 | 4.3 | CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 | nan | ||
CHEMBL3642170 | 124273 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 565 | 5 | 1 | 4 | 4.3 | CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 | nan | ||
44322724 | 204574 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 474 | 6 | 1 | 3 | 5.2 | Cc1cccc(CN(C(=O)COc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 | 10.1016/s0960-894x(01)00727-2 | ||
CHEMBL87066 | 204574 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 474 | 6 | 1 | 3 | 5.2 | Cc1cccc(CN(C(=O)COc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 | 10.1016/s0960-894x(01)00727-2 | ||
24800577 | 87000 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 448 | 6 | 1 | 5 | 3.7 | CN1CCN(c2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)n2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333628 | 87000 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 448 | 6 | 1 | 5 | 3.7 | CN1CCN(c2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)n2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
15755302 | 101849 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 614 | 16 | 4 | 8 | 2.9 | CSCC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL303543 | 101849 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 614 | 16 | 4 | 8 | 2.9 | CSCC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
44458869 | 11881 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 420 | 2 | 0 | 2 | 6.2 | CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C | 10.1021/jm00085a015 | ||
CHEMBL1183106 | 11881 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 420 | 2 | 0 | 2 | 6.2 | CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C | 10.1021/jm00085a015 | ||
CHEMBL280339 | 11881 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 420 | 2 | 0 | 2 | 6.2 | CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C | 10.1021/jm00085a015 | ||
44375286 | 119605 | 0 | None | - | 0 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 628 | 12 | 4 | 8 | 4.2 | CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | ||
CHEMBL351059 | 119605 | 0 | None | - | 0 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 628 | 12 | 4 | 8 | 4.2 | CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | ||
9827668 | 111780 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 420 | 8 | 2 | 3 | 4.1 | NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
CHEMBL329105 | 111780 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 420 | 8 | 2 | 3 | 4.1 | NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/s0960-894x(97)10163-9 | ||
11647974 | 105331 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 445 | 6 | 0 | 2 | 6.3 | CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126970 | 105331 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 445 | 6 | 0 | 2 | 6.3 | CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2014.01.036 | ||
9938657 | 59906 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 565 | 8 | 2 | 3 | 5.9 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 | 10.1021/jm00006a012 | ||
CHEMBL174038 | 59906 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 565 | 8 | 2 | 3 | 5.9 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 | 10.1021/jm00006a012 | ||
9827668 | 111780 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 420 | 8 | 2 | 3 | 4.1 | NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL329105 | 111780 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 420 | 8 | 2 | 3 | 4.1 | NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
44458598 | 98392 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 489 | 6 | 1 | 4 | 5.7 | CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00035a006 | ||
CHEMBL278849 | 98392 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 489 | 6 | 1 | 4 | 5.7 | CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm00035a006 | ||
107686 | 3327 | 37 | None | 15 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
3522 | 3327 | 37 | None | 15 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL131171 | 3327 | 37 | None | 15 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1016/0960-894X(95)00277-Z | ||
44274331 | 82048 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 483 | 7 | 1 | 4 | 5.4 | COc1cccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)c1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21759 | 82048 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 483 | 7 | 1 | 4 | 5.4 | COc1cccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)c1 | 10.1016/s0960-894x(01)00183-4 | ||
44433799 | 88240 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 582 | 5 | 0 | 4 | 5.8 | Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 | 10.1016/j.bmcl.2007.08.028 | ||
CHEMBL235882 | 88240 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 582 | 5 | 0 | 4 | 5.8 | Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 | 10.1016/j.bmcl.2007.08.028 | ||
44306000 | 100416 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 8 | 2 | 3 | 3.8 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCN1C(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL293675 | 100416 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 8 | 2 | 3 | 3.8 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCN1C(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
44370925 | 119108 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 654 | 17 | 1 | 4 | 7.2 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCCN(CC)CC)C1 | 10.1016/0960-894X(95)00080-D | ||
CHEMBL346485 | 119108 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 654 | 17 | 1 | 4 | 7.2 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCCN(CC)CC)C1 | 10.1016/0960-894X(95)00080-D | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00006a012 | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00006a012 | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm00006a012 | ||
58993629 | 121589 | 0 | None | - | 0 | Mongolian jird | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 451 | 6 | 1 | 4 | 5.5 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)nc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596490 | 121589 | 0 | None | - | 0 | Mongolian jird | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 451 | 6 | 1 | 4 | 5.5 | N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)nc1 | 10.1016/j.bmcl.2015.04.098 | ||
24888772 | 7934 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 564 | 5 | 0 | 3 | 7.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090752 | 7934 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 564 | 5 | 0 | 3 | 7.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44319307 | 106065 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 5.1 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL314119 | 106065 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 5.1 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
44415399 | 79644 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 487 | 6 | 0 | 3 | 6.1 | FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCOCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL212978 | 79644 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 487 | 6 | 0 | 3 | 6.1 | FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCOCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.035 | ||
44415449 | 79855 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 460 | 7 | 2 | 3 | 4.6 | NC(=O)CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL213908 | 79855 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 460 | 7 | 2 | 3 | 4.6 | NC(=O)CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
44290030 | 172966 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 527 | 10 | 2 | 5 | 4.3 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)Cc1ccc2c(c1)OCCO2)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL45316 | 172966 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 527 | 10 | 2 | 5 | 4.3 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)Cc1ccc2c(c1)OCCO2)C(C)=O | 10.1016/s0960-894x(01)00250-5 | ||
19797439 | 36655 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 443 | 8 | 0 | 4 | 5.5 | COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 | 10.1021/jm00024a007 | ||
CHEMBL145077 | 36655 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 443 | 8 | 0 | 4 | 5.5 | COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 | 10.1021/jm00024a007 | ||
10577745 | 56849 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 3.6 | COc1ccccc1CN(CC(Cc1ccccc1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL164563 | 56849 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 3.6 | COc1ccccc1CN(CC(Cc1ccccc1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O | 10.1021/jm950616c | ||
24782913 | 121576 | 0 | None | - | 0 | Mongolian jird | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 439 | 6 | 1 | 2 | 6.5 | Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596477 | 121576 | 0 | None | - | 0 | Mongolian jird | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 439 | 6 | 1 | 2 | 6.5 | Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2015.04.098 | ||
57402686 | 71261 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 3.8 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL1963297 | 71261 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 3.8 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL3217199 | 71261 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 3.8 | COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 | 10.1016/j.bmc.2011.08.070 | ||
10053175 | 4800 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 4 | 0 | 3 | 7.1 | Cc1cc2c(-c3ccccc3)c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
CHEMBL104370 | 4800 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 4 | 0 | 3 | 7.1 | Cc1cc2c(-c3ccccc3)c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C | 10.1021/jm00016a014 | ||
44319223 | 106621 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 669 | 11 | 1 | 7 | 5.7 | COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL315982 | 106621 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 669 | 11 | 1 | 7 | 5.7 | COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 | 10.1016/S0960-894X(97)10013-0 | ||
10202046 | 120548 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL356912 | 120548 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 416 | 6 | 1 | 2 | 5.7 | Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
46884471 | 7667 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 564 | 5 | 0 | 3 | 7.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1089062 | 7667 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 564 | 5 | 0 | 3 | 7.2 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44352062 | 18745 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
CHEMBL128586 | 18745 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 573 | 3 | 0 | 4 | 7.1 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
44319355 | 105043 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 605 | 10 | 1 | 6 | 5.1 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL312173 | 105043 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 605 | 10 | 1 | 6 | 5.1 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
71541473 | 86978 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 450 | 6 | 0 | 3 | 5.9 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3(C)C)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333607 | 86978 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 450 | 6 | 0 | 3 | 5.9 | CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3(C)C)n2)(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2012.11.094 | ||
107686 | 3327 | 37 | None | - | 2 | Mouse | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
3522 | 3327 | 37 | None | - | 2 | Mouse | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
CHEMBL131171 | 3327 | 37 | None | - | 2 | Mouse | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1021/jm950616c | ||
44319308 | 105897 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 709 | 10 | 0 | 7 | 6.1 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL313931 | 105897 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 709 | 10 | 0 | 7 | 6.1 | COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
44274181 | 77857 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 557 | 7 | 1 | 4 | 6.7 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(OC(F)(F)F)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL21062 | 77857 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 557 | 7 | 1 | 4 | 6.7 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(OC(F)(F)F)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
44358475 | 30147 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 613 | 7 | 0 | 5 | 6.2 | CN(CC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
CHEMBL139189 | 30147 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 613 | 7 | 0 | 5 | 6.2 | CN(CC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm000986n | ||
10063954 | 98279 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 309 | 5 | 1 | 2 | 4.1 | Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm9700171 | ||
CHEMBL277918 | 98279 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 309 | 5 | 1 | 2 | 4.1 | Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm9700171 | ||
44297484 | 194329 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 533 | 9 | 1 | 5 | 3.7 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL56003 | 194329 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 533 | 9 | 1 | 5 | 3.7 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
18986937 | 167594 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 369 | 5 | 1 | 2 | 5.5 | Cc1cc(C)cc(COCC(N)C2c3ccccc3C=Cc3ccccc32)c1 | 10.1016/S0960-894X(00)80063-3 | ||
CHEMBL433107 | 167594 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 369 | 5 | 1 | 2 | 5.5 | Cc1cc(C)cc(COCC(N)C2c3ccccc3C=Cc3ccccc32)c1 | 10.1016/S0960-894X(00)80063-3 | ||
68930433 | 124269 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 583 | 4 | 0 | 3 | 5.7 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
CHEMBL3642166 | 124269 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 583 | 4 | 0 | 3 | 5.7 | CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 | nan | ||
19797417 | 37084 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 417 | 6 | 0 | 2 | 6.2 | Clc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
CHEMBL145414 | 37084 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 417 | 6 | 0 | 2 | 6.2 | Clc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
10099318 | 56891 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
CHEMBL164912 | 56891 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O | 10.1021/jm950616c | ||
14986135 | 162849 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL419500 | 162849 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
44337620 | 109251 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 595 | 9 | 2 | 5 | 5.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
CHEMBL322976 | 109251 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 595 | 9 | 2 | 5 | 5.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
9979913 | 107985 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 426 | 6 | 0 | 4 | 5.5 | COc1ccccc1CN(C)Cc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL319932 | 107985 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 426 | 6 | 0 | 4 | 5.5 | COc1ccccc1CN(C)Cc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C | 10.1021/jm00016a014 | ||
104974 | 3419 | 27 | None | -1202 | 7 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/s0960-894x(98)00395-3 | ||
2111 | 3419 | 27 | None | -1202 | 7 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/s0960-894x(98)00395-3 | ||
3481 | 3419 | 27 | None | -1202 | 7 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL308148 | 3419 | 27 | None | -1202 | 7 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/s0960-894x(98)00395-3 | ||
DB06660 | 3419 | 27 | None | -1202 | 7 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/s0960-894x(98)00395-3 | ||
CHEMBL334721 | 209653 | 1 | None | - | 3 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 | 10.1016/S0960-894X(96)00570-7 | ||||
44358520 | 30157 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 555 | 8 | 1 | 3 | 5.9 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL139198 | 30157 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 555 | 8 | 1 | 3 | 5.9 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1 | 10.1021/jm000986n | ||
44346693 | 15229 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 421 | 9 | 1 | 2 | 7.1 | Cc1cc(C)cc(COC[C@@H](Nc2ccccc2)C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm9700171 | ||
CHEMBL121480 | 15229 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 421 | 9 | 1 | 2 | 7.1 | Cc1cc(C)cc(COC[C@@H](Nc2ccccc2)C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm9700171 | ||
44366601 | 42181 | 9 | None | - | 0 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 323 | 4 | 0 | 3 | 3.5 | O=C1CCN(C(=O)OCc2ccccc2)CC1Cc1ccccc1 | 10.1016/0960-894X(94)80030-8 | ||
CHEMBL149905 | 42181 | 9 | None | - | 0 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 323 | 4 | 0 | 3 | 3.5 | O=C1CCN(C(=O)OCc2ccccc2)CC1Cc1ccccc1 | 10.1016/0960-894X(94)80030-8 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80246-2 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80246-2 | ||
44346200 | 14296 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(CO[C@@H]2/C(=C/c3ccccc3)N3CCC2CC3)c1 | 10.1021/jm9700171 | ||
CHEMBL120038 | 14296 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(CO[C@@H]2/C(=C/c3ccccc3)N3CCC2CC3)c1 | 10.1021/jm9700171 | ||
44299876 | 162627 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 435 | 10 | 1 | 2 | 6.8 | Cc1cc(C)cc(COCC(NCc2ccccc2)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL418114 | 162627 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 435 | 10 | 1 | 2 | 6.8 | Cc1cc(C)cc(COCC(NCc2ccccc2)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
44274392 | 77737 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 483 | 7 | 1 | 4 | 5.4 | COc1ccccc1-c1[nH]c2ccc(C)cc2c1CCC(=O)N1CCN(c2ccccc2OC)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21018 | 77737 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 483 | 7 | 1 | 4 | 5.4 | COc1ccccc1-c1[nH]c2ccc(C)cc2c1CCC(=O)N1CCN(c2ccccc2OC)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
22293476 | 79295 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 592 | 7 | 1 | 2 | 8.7 | Fc1ccc(C2CCN([C@H]3CC[C@@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2115450 | 79295 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 592 | 7 | 1 | 2 | 8.7 | Fc1ccc(C2CCN([C@H]3CC[C@@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 | 10.1016/s0960-894x(02)00249-4 | ||
44337569 | 9130 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 597 | 9 | 2 | 5 | 5.3 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
CHEMBL110558 | 9130 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 597 | 9 | 2 | 5 | 5.3 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
10520658 | 98194 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL277260 | 98194 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 333 | 4 | 0 | 2 | 5.0 | Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL2369630 | 207900 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm000316h | ||||
9851211 | 5128 | 28 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 579 | 9 | 2 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
CHEMBL106092 | 5128 | 28 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 579 | 9 | 2 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
44287606 | 100045 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 470 | 5 | 0 | 4 | 4.6 | CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL291146 | 100045 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 470 | 5 | 0 | 4 | 4.6 | CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
10344874 | 119645 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 7 | 3 | 5 | 4.6 | O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] | 10.1016/s0960-894x(01)00044-0 | ||
CHEMBL351387 | 119645 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 7 | 3 | 5 | 4.6 | O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] | 10.1016/s0960-894x(01)00044-0 | ||
10907460 | 9735 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 521 | 11 | 1 | 3 | 5.8 | CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | ||
CHEMBL113956 | 9735 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 521 | 11 | 1 | 3 | 5.8 | CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | ||
10548166 | 34874 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 349 | 5 | 1 | 2 | 4.5 | FC(F)(F)c1ccccc1COCC1(c2ccccc2)CCNCC1 | 10.1021/jm980376b | ||
CHEMBL143377 | 34874 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 349 | 5 | 1 | 2 | 4.5 | FC(F)(F)c1ccccc1COCC1(c2ccccc2)CCNCC1 | 10.1021/jm980376b | ||
68928720 | 124277 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 609 | 5 | 1 | 4 | 4.4 | CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 | nan | ||
CHEMBL3642174 | 124277 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 609 | 5 | 1 | 4 | 4.4 | CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 | nan | ||
10454303 | 5411 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 411 | 3 | 2 | 3 | 5.8 | Cc1cccc(NC(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 | 10.1021/jm00016a014 | ||
CHEMBL107619 | 5411 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 411 | 3 | 2 | 3 | 5.8 | Cc1cccc(NC(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 | 10.1021/jm00016a014 | ||
44458353 | 99143 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 335 | 5 | 0 | 2 | 4.5 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(95)00205-8 | ||
CHEMBL283979 | 99143 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 335 | 5 | 0 | 2 | 4.5 | Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(95)00205-8 | ||
44307090 | 100243 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 461 | 6 | 1 | 3 | 5.5 | O=C(O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
CHEMBL292496 | 100243 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 461 | 6 | 1 | 3 | 5.5 | O=C(O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/0960-894X(95)00009-I | ||
21955298 | 79296 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2115451 | 79296 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 606 | 6 | 1 | 2 | 8.2 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 | 10.1016/s0960-894x(02)00249-4 | ||
CHEMBL2369607 | 207895 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm960281e | ||||
10840161 | 167706 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 539 | 12 | 2 | 5 | 4.5 | CCN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
CHEMBL433906 | 167706 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 539 | 12 | 2 | 5 | 4.5 | CCN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 | 10.1021/jm950616c | ||
9832198 | 106273 | 0 | None | 100 | 3 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 788 | 15 | 4 | 8 | 3.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
CHEMBL3144351 | 106273 | 0 | None | 100 | 3 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 788 | 15 | 4 | 8 | 3.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O | 10.1021/jm00063a015 | ||
44294408 | 11146 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 434 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1178974 | 11146 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 434 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL52114 | 11146 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 434 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
44294305 | 11935 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 8 | 0 | 6 | 5.6 | CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
74972643 | 11935 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 8 | 0 | 6 | 5.6 | CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1183417 | 11935 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 8 | 0 | 6 | 5.6 | CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL295781 | 11935 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 8 | 0 | 6 | 5.6 | CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
21994241 | 29554 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 469 | 8 | 1 | 4 | 4.7 | COc1ccccc1C(CNC(=O)Cc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
CHEMBL138695 | 29554 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 469 | 8 | 1 | 4 | 4.7 | COc1ccccc1C(CNC(=O)Cc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 | 10.1021/jm000986n | ||
71458099 | 79181 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 589 | 7 | 2 | 3 | 5.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(00)00260-2 | ||
CHEMBL2114398 | 79181 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 589 | 7 | 2 | 3 | 5.4 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 | 10.1016/s0960-894x(00)00260-2 | ||
44348676 | 17767 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 441 | 1 | 1 | 4 | 5.8 | C=C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
CHEMBL126009 | 17767 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 441 | 1 | 1 | 4 | 5.8 | C=C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C | 10.1021/jm00080a025 | ||
19797445 | 118933 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 408 | 6 | 0 | 3 | 5.4 | N#Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
CHEMBL344970 | 118933 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 408 | 6 | 0 | 3 | 5.4 | N#Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
44383265 | 120009 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 456 | 8 | 1 | 4 | 5.5 | COc1ccc(CN[C@H]2C3CCCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c(OC)c1 | 10.1016/S0960-894X(00)80693-9 | ||
CHEMBL354542 | 120009 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 456 | 8 | 1 | 4 | 5.5 | COc1ccc(CN[C@H]2C3CCCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c(OC)c1 | 10.1016/S0960-894X(00)80693-9 | ||
10408564 | 5906 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 5 | 1 | 4 | 4.1 | COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
CHEMBL108010 | 5906 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 5 | 1 | 4 | 4.1 | COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C | 10.1021/jm00016a014 | ||
10474902 | 88257 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 3.8 | COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
CHEMBL23597 | 88257 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 380 | 6 | 2 | 4 | 3.8 | COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 | 10.1021/jm00035a006 | ||
44299830 | 195002 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 417 | 3 | 1 | 3 | 4.9 | FC(F)(F)c1cc(C2OC2[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80534-5 | ||
CHEMBL56458 | 195002 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 417 | 3 | 1 | 3 | 4.9 | FC(F)(F)c1cc(C2OC2[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(01)80534-5 | ||
44274326 | 81140 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 457 | 6 | 1 | 3 | 5.3 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(F)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL21612 | 81140 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 457 | 6 | 1 | 3 | 5.3 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(F)cc23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
58993640 | 121548 | 0 | None | - | 0 | Mongolian jird | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 393 | 7 | 1 | 7 | 2.8 | COc1ccc(-n2nnnc2C)cc1COCC1(c2ccccc2)CCNCC1 | 10.1016/j.bmcl.2015.04.098 | ||
CHEMBL3596449 | 121548 | 0 | None | - | 0 | Mongolian jird | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 393 | 7 | 1 | 7 | 2.8 | COc1ccc(-n2nnnc2C)cc1COCC1(c2ccccc2)CCNCC1 | 10.1016/j.bmcl.2015.04.098 | ||
2090 | 2726 | 20 | None | - | 4 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80229-8 | ||||
5311312 | 2726 | 20 | None | - | 4 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80229-8 | ||||
CHEMBL437797 | 2726 | 20 | None | - | 4 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80229-8 | ||||
44297523 | 100226 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 9 | 1 | 6 | 4.2 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NS(=O)(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL292404 | 100226 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 9 | 1 | 6 | 4.2 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NS(=O)(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44288770 | 159265 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 557 | 7 | 1 | 3 | 7.6 | FC(F)(F)c1cc(CN2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL41057 | 159265 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 557 | 7 | 1 | 3 | 7.6 | FC(F)(F)c1cc(CN2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(96)00287-9 | ||
10408912 | 95962 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 404 | 4 | 0 | 2 | 6.2 | FC(F)(F)c1cc(CO[C@H]2CCCO[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00220-N | ||
CHEMBL26193 | 95962 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 404 | 4 | 0 | 2 | 6.2 | FC(F)(F)c1cc(CO[C@H]2CCCO[C@H]2c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/0960-894X(95)00220-N | ||
44274534 | 98502 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.2 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3Br)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL279726 | 98502 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 6.2 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3Br)[nH]c3ccc(C)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
46884431 | 7972 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 563 | 5 | 0 | 2 | 7.8 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1091043 | 7972 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 563 | 5 | 0 | 2 | 7.8 | C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
54581461 | 60934 | 0 | None | -2089 | 4 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 1143 | 29 | 10 | 12 | 4.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 | 10.1021/jm101023r | ||
CHEMBL1766207 | 60934 | 0 | None | -2089 | 4 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 1143 | 29 | 10 | 12 | 4.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 | 10.1021/jm101023r | ||
44276792 | 98674 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 604 | 8 | 1 | 4 | 6.5 | O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1016/s0960-894x(98)00215-7 | ||
CHEMBL281019 | 98674 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 604 | 8 | 1 | 4 | 6.5 | O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1016/s0960-894x(98)00215-7 | ||
44297685 | 100609 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3c(Cl)cccc3Cl)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
CHEMBL294843 | 100609 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 601 | 9 | 1 | 5 | 5.0 | CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3c(Cl)cccc3Cl)CC2)c2ccccc21 | 10.1016/s0960-894x(98)00320-5 | ||
44334072 | 5026 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 7.2 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)c(Cl)c2)c1 | 10.1016/S0960-894X(96)00563-X | ||
CHEMBL105560 | 5026 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 7.2 | Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)c(Cl)c2)c1 | 10.1016/S0960-894X(96)00563-X | ||
11295303 | 94619 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 517 | 5 | 1 | 3 | 6.7 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CN)nc2ccccc2c1-c1ccccc1 | 10.1021/jm034219a | ||
CHEMBL25521 | 94619 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 517 | 5 | 1 | 3 | 6.7 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CN)nc2ccccc2c1-c1ccccc1 | 10.1021/jm034219a | ||
44305557 | 201125 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 522 | 8 | 2 | 5 | 6.3 | COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC | 10.1021/jm058225d | ||
CHEMBL62341 | 201125 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 522 | 8 | 2 | 5 | 6.3 | COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC | 10.1021/jm058225d | ||
44287803 | 99747 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 456 | 5 | 1 | 4 | 5.0 | COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
CHEMBL288371 | 99747 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 456 | 5 | 1 | 4 | 5.0 | COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 | 10.1016/0960-894X(95)00277-Z | ||
44410194 | 76530 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 511 | 5 | 1 | 6 | 5.0 | Cn1nnnc1C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
CHEMBL206983 | 76530 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 511 | 5 | 1 | 6 | 5.0 | Cn1nnnc1C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.12.069 | ||
16755253 | 185607 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 528 | 4 | 0 | 4 | 6.9 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cnnc12 | 10.1016/j.bmc.2008.05.067 | ||
CHEMBL487276 | 185607 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 528 | 4 | 0 | 4 | 6.9 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cnnc12 | 10.1016/j.bmc.2008.05.067 | ||
118722858 | 115694 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 399 | 7 | 1 | 5 | 4.9 | O=C(N[C@@H](Cc1ccccc1)c1nnc(-c2ccccc2)o1)OCc1ccccc1 | 10.1021/ml5002954 | ||
CHEMBL3358424 | 115694 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 399 | 7 | 1 | 5 | 4.9 | O=C(N[C@@H](Cc1ccccc1)c1nnc(-c2ccccc2)o1)OCc1ccccc1 | 10.1021/ml5002954 | ||
44306757 | 100485 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 511 | 9 | 2 | 4 | 3.0 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)/C=C/c1ccccc1 | 10.1021/jm00039a022 | ||
CHEMBL294114 | 100485 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 511 | 9 | 2 | 4 | 3.0 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)/C=C/c1ccccc1 | 10.1021/jm00039a022 | ||
44306092 | 201733 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 525 | 11 | 4 | 4 | 2.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL65703 | 201733 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 525 | 11 | 4 | 4 | 2.5 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00039a022 | ||
44324793 | 205274 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 670 | 17 | 2 | 5 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCc2ccccc2OC)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL91438 | 205274 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 670 | 17 | 2 | 5 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCc2ccccc2OC)C1 | 10.1016/S0960-894X(01)80747-2 | ||
44324775 | 205583 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 684 | 17 | 1 | 5 | 7.0 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL93401 | 205583 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 684 | 17 | 1 | 5 | 7.0 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 | 10.1016/S0960-894X(01)80747-2 | ||
44289197 | 100685 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 601 | 5 | 2 | 4 | 6.6 | O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1)c1cc(O)nc2ccccc12 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL295425 | 100685 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 601 | 5 | 2 | 4 | 6.6 | O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1)c1cc(O)nc2ccccc12 | 10.1016/0960-894X(96)00287-9 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
19797460 | 120499 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.8 | Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
CHEMBL356518 | 120499 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 451 | 6 | 0 | 2 | 6.8 | Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm00024a007 | ||
44305557 | 201125 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 522 | 8 | 2 | 5 | 6.3 | COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/s0960-894x(02)00382-7 | ||
CHEMBL62341 | 201125 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 522 | 8 | 2 | 5 | 6.3 | COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/s0960-894x(02)00382-7 | ||
10063954 | 98279 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 309 | 5 | 1 | 2 | 4.1 | Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
CHEMBL277918 | 98279 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 309 | 5 | 1 | 2 | 4.1 | Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 | 10.1021/jm980376b | ||
71541472 | 86977 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 436 | 6 | 0 | 3 | 5.5 | CC1CC1c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
CHEMBL2333606 | 86977 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 436 | 6 | 0 | 3 | 5.5 | CC1CC1c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 | 10.1016/j.bmcl.2012.11.094 | ||
44346536 | 16129 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 4.3 | COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 | 10.1021/jm9700171 | ||
CHEMBL122580 | 16129 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 4.3 | COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 | 10.1021/jm9700171 | ||
44306106 | 102334 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 556 | 8 | 2 | 5 | 3.3 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
CHEMBL305368 | 102334 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 556 | 8 | 2 | 5 | 3.3 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 | 10.1021/jm00039a022 | ||
10531588 | 119849 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 597 | 13 | 3 | 6 | 3.5 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CC(=O)O | 10.1021/jm950616c | ||
CHEMBL353116 | 119849 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 597 | 13 | 3 | 6 | 3.5 | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CC(=O)O | 10.1021/jm950616c | ||
44346536 | 16129 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 4.3 | COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 | 10.1016/S0960-894X(01)80859-3 | ||
CHEMBL122580 | 16129 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 4.3 | COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 | 10.1016/S0960-894X(01)80859-3 | ||
19049319 | 162584 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 345 | 7 | 1 | 2 | 5.0 | Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(00)80063-3 | ||
CHEMBL417784 | 162584 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 345 | 7 | 1 | 2 | 5.0 | Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(00)80063-3 | ||
19049319 | 162584 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 345 | 7 | 1 | 2 | 5.0 | Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL417784 | 162584 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 345 | 7 | 1 | 2 | 5.0 | Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
19797439 | 36655 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 443 | 8 | 0 | 4 | 5.5 | COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 | 10.1021/jm00024a007 | ||
CHEMBL145077 | 36655 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 443 | 8 | 0 | 4 | 5.5 | COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 | 10.1021/jm00024a007 | ||
19049319 | 162584 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 345 | 7 | 1 | 2 | 5.0 | Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm0311487 | ||
CHEMBL417784 | 162584 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 345 | 7 | 1 | 2 | 5.0 | Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 | 10.1021/jm0311487 | ||
56658036 | 66130 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 451 | 7 | 0 | 4 | 5.2 | COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817885 | 66130 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 451 | 7 | 0 | 4 | 5.2 | COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852128 | 66130 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 451 | 7 | 0 | 4 | 5.2 | COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 | 10.1016/j.bmc.2011.07.014 | ||
23653789 | 3530 | 19 | None | - | 2 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm400751p | ||
9280 | 3530 | 19 | None | - | 2 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm400751p | ||
CHEMBL447955 | 3530 | 19 | None | - | 2 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm400751p | ||
DB12973 | 3530 | 19 | None | - | 2 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm400751p | ||
23653789 | 3530 | 19 | None | - | 2 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm8016514 | ||
9280 | 3530 | 19 | None | - | 2 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm8016514 | ||
CHEMBL447955 | 3530 | 19 | None | - | 2 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm8016514 | ||
DB12973 | 3530 | 19 | None | - | 2 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 10.1021/jm8016514 | ||
10698085 | 19207 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 559 | 3 | 0 | 4 | 6.7 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
CHEMBL129354 | 19207 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 559 | 3 | 0 | 4 | 6.7 | Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 | 10.1021/jm990220r | ||
24888942 | 7864 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 569 | 5 | 0 | 3 | 7.0 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
CHEMBL1090437 | 7864 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 569 | 5 | 0 | 3 | 7.0 | C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.01.120 | ||
44299463 | 194869 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 409 | 7 | 1 | 2 | 5.4 | Cc1cc(Br)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL56372 | 194869 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 409 | 7 | 1 | 2 | 5.4 | Cc1cc(Br)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
44290080 | 193188 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 499 | 11 | 2 | 4 | 4.5 | COc1ccc(CC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 | 10.1016/s0960-894x(01)00250-5 | ||
CHEMBL539937 | 193188 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 499 | 11 | 2 | 4 | 4.5 | COc1ccc(CC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 | 10.1016/s0960-894x(01)00250-5 | ||
44319356 | 103892 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 607 | 10 | 1 | 6 | 4.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
CHEMBL310173 | 103892 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 607 | 10 | 1 | 6 | 4.7 | COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC | 10.1016/S0960-894X(97)10013-0 | ||
44415529 | 139497 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 446 | 5 | 2 | 2 | 5.2 | NC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
CHEMBL380017 | 139497 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 446 | 5 | 2 | 2 | 5.2 | NC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 | 10.1016/j.bmcl.2006.06.035 | ||
24993313 | 186448 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 532 | 4 | 1 | 2 | 6.8 | CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 | 10.1021/jm8016514 | ||
CHEMBL490869 | 186448 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 532 | 4 | 1 | 2 | 6.8 | CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 | 10.1021/jm8016514 | ||
10499846 | 31008 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 341 | 7 | 1 | 4 | 3.5 | COc1cc(COCC2(c3ccccc3)CCNCC2)cc(OC)c1 | 10.1021/jm980376b | ||
CHEMBL140101 | 31008 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 341 | 7 | 1 | 4 | 3.5 | COc1cc(COCC2(c3ccccc3)CCNCC2)cc(OC)c1 | 10.1021/jm980376b | ||
130847 | 198896 | 13 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 697 | 16 | 4 | 9 | 3.3 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
CHEMBL59915 | 198896 | 13 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 697 | 16 | 4 | 9 | 3.3 | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 | 10.1021/jm00089a011 | ||
43815 | 186337 | 58 | None | - | 24 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL1708 | 186337 | 58 | None | - | 24 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL490 | 186337 | 58 | None | - | 24 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | 10.1016/j.bmc.2013.02.010 | ||
CHEMBL2112245 | 207488 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O | 10.1021/jm000316h | ||||
54581252 | 60824 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 486 | 4 | 0 | 2 | 7.0 | Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765496 | 60824 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 486 | 4 | 0 | 2 | 7.0 | Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
11248796 | 161100 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 488 | 4 | 0 | 2 | 7.2 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL413027 | 161100 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 488 | 4 | 0 | 2 | 7.2 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 | 10.1016/j.bmc.2011.02.031 | ||
44289102 | 167944 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 495 | 8 | 1 | 5 | 5.3 | COc1cc(OC)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
CHEMBL435367 | 167944 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 495 | 8 | 1 | 5 | 5.3 | COc1cc(OC)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 | 10.1016/0960-894X(96)00287-9 | ||
76311027 | 105329 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 499 | 6 | 0 | 2 | 7.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)CC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
CHEMBL3126969 | 105329 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 499 | 6 | 0 | 2 | 7.6 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)CC2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2014.01.036 | ||
18986942 | 202217 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 371 | 5 | 1 | 2 | 5.1 | Cc1cc(C)cc(COCC(N)C2c3ccccc3CCc3ccccc32)c1 | 10.1016/S0960-894X(00)80063-3 | ||
CHEMBL69051 | 202217 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 371 | 5 | 1 | 2 | 5.1 | Cc1cc(C)cc(COCC(N)C2c3ccccc3CCc3ccccc32)c1 | 10.1016/S0960-894X(00)80063-3 | ||
44299898 | 162579 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 399 | 10 | 1 | 2 | 6.0 | Cc1cc(C)cc(COCC(NCC2CC2)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
CHEMBL417766 | 162579 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 399 | 10 | 1 | 2 | 6.0 | Cc1cc(C)cc(COCC(NCC2CC2)C(c2ccccc2)c2ccccc2)c1 | 10.1016/S0960-894X(01)80531-X | ||
19797414 | 36948 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 401 | 6 | 0 | 2 | 5.6 | Fc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
CHEMBL145308 | 36948 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 401 | 6 | 0 | 2 | 5.6 | Fc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 | 10.1021/jm00024a007 | ||
44324681 | 111973 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 592 | 14 | 0 | 4 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)C)C1 | 10.1016/S0960-894X(01)80747-2 | ||
CHEMBL329840 | 111973 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 592 | 14 | 0 | 4 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)C)C1 | 10.1016/S0960-894X(01)80747-2 | ||
44281769 | 109172 | 7 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 484 | 10 | 4 | 4 | 3.2 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(01)80821-0 | ||
CHEMBL32248 | 109172 | 7 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 484 | 10 | 4 | 4 | 3.2 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(01)80821-0 | ||
44345938 | 11898 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 350 | 7 | 4 | 3 | 1.3 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 | 10.1016/S0960-894X(96)00570-7 | ||
CHEMBL118328 | 11898 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 350 | 7 | 4 | 3 | 1.3 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 | 10.1016/S0960-894X(96)00570-7 | ||
10339539 | 109280 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 377 | 5 | 1 | 2 | 5.3 | CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL323128 | 109280 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 377 | 5 | 1 | 2 | 5.3 | CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 | 10.1016/0960-894X(95)00476-A | ||
CHEMBL2092730 | 207457 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | C[C@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm960281e | ||||
45271306 | 193999 | 0 | None | -645 | 4 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1438 | 33 | 14 | 16 | 3.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL556537 | 193999 | 0 | None | -645 | 4 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1438 | 33 | 14 | 16 | 3.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
46227362 | 200897 | 0 | None | -301 | 4 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL611926 | 200897 | 0 | None | -301 | 4 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
44274254 | 79796 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 6 | 1 | 3 | 6.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cccc(Cl)c23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
CHEMBL21366 | 79796 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 6 | 1 | 3 | 6.4 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cccc(Cl)c23)CC1 | 10.1016/s0960-894x(01)00182-2 | ||
11661466 | 36685 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 408 | 6 | 0 | 3 | 5.4 | N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
CHEMBL145103 | 36685 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 408 | 6 | 0 | 3 | 5.4 | N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00024a007 | ||
CHEMBL2112246 | 207489 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm000316h | ||||
44274444 | 82166 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 597 | 8 | 0 | 4 | 8.0 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(Cc3ccccc3)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
CHEMBL21787 | 82166 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 597 | 8 | 0 | 4 | 8.0 | COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(Cc3ccccc3)c3ccc(Cl)cc23)CC1 | 10.1016/s0960-894x(01)00183-4 | ||
11801586 | 5392 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 591 | 9 | 3 | 4 | 5.2 | CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL107502 | 5392 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 591 | 9 | 3 | 4 | 5.2 | CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL2112245 | 207488 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O | 10.1021/jm000316h | ||||
CHEMBL2369766 | 207938 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O | 10.1016/0960-894X(94)85022-4 | ||||
56671764 | 66109 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 423 | 5 | 0 | 2 | 6.2 | O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817821 | 66109 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 423 | 5 | 0 | 2 | 6.2 | O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852008 | 66109 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 423 | 5 | 0 | 2 | 6.2 | O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 | 10.1016/j.bmc.2011.07.014 | ||
56671762 | 66127 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 391 | 5 | 0 | 2 | 5.2 | O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817820 | 66127 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 391 | 5 | 0 | 2 | 5.2 | O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852121 | 66127 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 391 | 5 | 0 | 2 | 5.2 | O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 | 10.1016/j.bmc.2011.07.014 | ||
23025476 | 66142 | 12 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 355 | 5 | 0 | 2 | 4.9 | O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1817817 | 66142 | 12 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 355 | 5 | 0 | 2 | 4.9 | O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2011.07.014 | ||
CHEMBL1852184 | 66142 | 12 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 355 | 5 | 0 | 2 | 4.9 | O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 | 10.1016/j.bmc.2011.07.014 | ||
2090 | 2726 | 20 | None | -309 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00582-E | ||||
5311312 | 2726 | 20 | None | -309 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00582-E | ||||
CHEMBL437797 | 2726 | 20 | None | -309 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | None | 10.1016/0960-894X(95)00582-E | ||||
44358847 | 29956 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 515 | 10 | 3 | 5 | 5.3 | COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1OC | 10.1021/jm00022a010 | ||
CHEMBL139017 | 29956 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 515 | 10 | 3 | 5 | 5.3 | COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1OC | 10.1021/jm00022a010 | ||
54586136 | 60820 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 452 | 4 | 0 | 2 | 6.4 | Cc1nccc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
CHEMBL1765492 | 60820 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 452 | 4 | 0 | 2 | 6.4 | Cc1nccc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.02.031 | ||
2090 | 2726 | 20 | None | -309 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950892r | ||||
5311312 | 2726 | 20 | None | -309 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950892r | ||||
CHEMBL437797 | 2726 | 20 | None | -309 | 4 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950892r | ||||
44375315 | 56213 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 628 | 12 | 4 | 8 | 4.2 | CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | ||
CHEMBL163510 | 56213 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 628 | 12 | 4 | 8 | 4.2 | CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | ||
44318671 | 105643 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 327 | 2 | 1 | 3 | 3.4 | Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2)C3)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL313432 | 105643 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 327 | 2 | 1 | 3 | 3.4 | Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2)C3)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
15037918 | 44600 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 400 | 6 | 1 | 2 | 5.2 | Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
CHEMBL152239 | 44600 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 400 | 6 | 1 | 2 | 5.2 | Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81197-5 | ||
5757 | 3923 | 10 | None | - | 1 | Human | 10.5 | pKd | = | 10.5 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1021/jm900023b | ||
9832383 | 3923 | 10 | None | - | 1 | Human | 10.5 | pKd | = | 10.5 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1021/jm900023b | ||
CHEMBL522987 | 3923 | 10 | None | - | 1 | Human | 10.5 | pKd | = | 10.5 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1021/jm900023b | ||
DB11949 | 3923 | 10 | None | - | 1 | Human | 10.5 | pKd | = | 10.5 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1021/jm900023b | ||
10907397 | 43636 | 0 | None | - | 1 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 515 | 7 | 1 | 4 | 4.6 | O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL151177 | 43636 | 0 | None | - | 1 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 515 | 7 | 1 | 4 | 4.6 | O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
44366788 | 43904 | 0 | None | - | 1 | Human | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 493 | 6 | 0 | 4 | 4.6 | O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1CCCCC1 | 10.1021/jm0209331 | ||
CHEMBL151585 | 43904 | 0 | None | - | 1 | Human | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 493 | 6 | 0 | 4 | 4.6 | O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1CCCCC1 | 10.1021/jm0209331 | ||
22901331 | 11876 | 0 | None | - | 1 | Rat | 9.7 | pKd | = | 9.7 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
54435601 | 11876 | 0 | None | - | 1 | Rat | 9.7 | pKd | = | 9.7 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
59922977 | 11876 | 0 | None | - | 1 | Rat | 9.7 | pKd | = | 9.7 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1183068 | 11876 | 0 | None | - | 1 | Rat | 9.7 | pKd | = | 9.7 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL278294 | 11876 | 0 | None | - | 1 | Rat | 9.7 | pKd | = | 9.7 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
18964186 | 202601 | 0 | None | 3 | 3 | Human | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 510 | 8 | 1 | 3 | 6.2 | CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL71397 | 202601 | 0 | None | 3 | 3 | Human | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 510 | 8 | 1 | 3 | 6.2 | CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 | 10.1021/jm0209331 | ||
2102 | 1166 | 17 | None | 2 | 2 | Guinea pig | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00073a022 | ||
5311057 | 1166 | 17 | None | 2 | 2 | Guinea pig | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00073a022 | ||
CHEMBL441225 | 1166 | 17 | None | 2 | 2 | Guinea pig | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00073a022 | ||
21836542 | 42057 | 0 | None | - | 1 | Human | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 4.1 | O=C(O)C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL149794 | 42057 | 0 | None | - | 1 | Human | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 4.1 | O=C(O)C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
11005795 | 41941 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Binding | ChEMBL | 515 | 7 | 0 | 4 | 4.8 | Cc1ccccc1CN1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CCC1=O | 10.1021/jm0209331 | ||
CHEMBL149690 | 41941 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Binding | ChEMBL | 515 | 7 | 0 | 4 | 4.8 | Cc1ccccc1CN1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CCC1=O | 10.1021/jm0209331 | ||
21699577 | 43102 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Binding | ChEMBL | 536 | 7 | 1 | 3 | 6.4 | O=C1CCC(CCN2CCC(O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL150709 | 43102 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Binding | ChEMBL | 536 | 7 | 1 | 3 | 6.4 | O=C1CCC(CCN2CCC(O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
10918128 | 119346 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Binding | ChEMBL | 501 | 7 | 0 | 4 | 4.5 | O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL348653 | 119346 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Binding | ChEMBL | 501 | 7 | 0 | 4 | 4.5 | O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
10973497 | 42991 | 0 | None | - | 1 | Human | 9.2 | pKd | = | 9.2 | Binding | ChEMBL | 533 | 7 | 0 | 4 | 4.2 | O=C1CCC(CCN2CC(N3CC[S+]([O-])CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL150619 | 42991 | 0 | None | - | 1 | Human | 9.2 | pKd | = | 9.2 | Binding | ChEMBL | 533 | 7 | 0 | 4 | 4.2 | O=C1CCC(CCN2CC(N3CC[S+]([O-])CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
23224631 | 43667 | 0 | None | - | 1 | Human | 9.2 | pKd | = | 9.2 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 5.1 | O=C1CCC(CCN2CC(N3C4CCC3CC(O)C4)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL151231 | 43667 | 0 | None | - | 1 | Human | 9.2 | pKd | = | 9.2 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 5.1 | O=C1CCC(CCN2CC(N3C4CCC3CC(O)C4)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
11071954 | 164786 | 0 | None | - | 1 | Human | 9.2 | pKd | = | 9.2 | Binding | ChEMBL | 578 | 8 | 0 | 5 | 3.7 | CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL423584 | 164786 | 0 | None | - | 1 | Human | 9.2 | pKd | = | 9.2 | Binding | ChEMBL | 578 | 8 | 0 | 5 | 3.7 | CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 | 10.1021/jm0209331 | ||
22901331 | 11876 | 0 | None | - | 1 | Rat | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
54435601 | 11876 | 0 | None | - | 1 | Rat | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
59922977 | 11876 | 0 | None | - | 1 | Rat | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1183068 | 11876 | 0 | None | - | 1 | Rat | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL278294 | 11876 | 0 | None | - | 1 | Rat | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
10864234 | 43733 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9 | Binding | ChEMBL | 517 | 7 | 0 | 4 | 5.2 | O=C1CCC(CCN2CC(N3CCSCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL151317 | 43733 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9 | Binding | ChEMBL | 517 | 7 | 0 | 4 | 5.2 | O=C1CCC(CCN2CC(N3CCSCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
10929285 | 66376 | 0 | None | 1 | 2 | Human | 9.0 | pKd | = | 9 | Binding | ChEMBL | 507 | 7 | 0 | 4 | 4.8 | O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 | 10.1021/jm0209331 | ||
CHEMBL185572 | 66376 | 0 | None | 1 | 2 | Human | 9.0 | pKd | = | 9 | Binding | ChEMBL | 507 | 7 | 0 | 4 | 4.8 | O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 | 10.1021/jm0209331 | ||
21836537 | 41123 | 5 | None | - | 1 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 543 | 8 | 1 | 5 | 2.2 | NS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL148998 | 41123 | 5 | None | - | 1 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 543 | 8 | 1 | 5 | 2.2 | NS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
44366712 | 43257 | 0 | None | - | 1 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 477 | 7 | 0 | 4 | 4.0 | O=C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL150842 | 43257 | 0 | None | - | 1 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 477 | 7 | 0 | 4 | 4.0 | O=C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
11028028 | 43424 | 0 | None | - | 1 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 549 | 7 | 0 | 5 | 3.9 | O=C1CCC(CCN2CC(N3CCS(=O)(=O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL150997 | 43424 | 0 | None | - | 1 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 549 | 7 | 0 | 5 | 3.9 | O=C1CCC(CCN2CC(N3CCS(=O)(=O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
11060266 | 43894 | 0 | None | - | 1 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 507 | 7 | 0 | 4 | 4.8 | O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 | 10.1021/jm0209331 | ||
CHEMBL151570 | 43894 | 0 | None | - | 1 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 507 | 7 | 0 | 4 | 4.8 | O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 | 10.1021/jm0209331 | ||
22901331 | 11876 | 0 | None | - | 1 | Rat | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
54435601 | 11876 | 0 | None | - | 1 | Rat | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
59922977 | 11876 | 0 | None | - | 1 | Rat | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1183068 | 11876 | 0 | None | - | 1 | Rat | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL278294 | 11876 | 0 | None | - | 1 | Rat | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
10984417 | 43533 | 0 | None | - | 1 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 542 | 7 | 0 | 4 | 4.3 | CC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL151088 | 43533 | 0 | None | - | 1 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 542 | 7 | 0 | 4 | 4.3 | CC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 | 10.1021/jm0209331 | ||
44366743 | 43715 | 0 | None | - | 1 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 479 | 7 | 1 | 4 | 3.8 | O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 | 10.1021/jm0209331 | ||
CHEMBL151289 | 43715 | 0 | None | - | 1 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 479 | 7 | 1 | 4 | 3.8 | O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 | 10.1021/jm0209331 | ||
11813113 | 42890 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 501 | 7 | 1 | 4 | 4.2 | O=C1CCC(CCN2CC(N3CCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL150537 | 42890 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 501 | 7 | 1 | 4 | 4.2 | O=C1CCC(CCN2CC(N3CCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
11827396 | 42961 | 1 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 515 | 7 | 1 | 4 | 4.6 | O=C1CCC(CCN2CC(N3CCCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL150585 | 42961 | 1 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 515 | 7 | 1 | 4 | 4.6 | O=C1CCC(CCN2CC(N3CCCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
21836550 | 118978 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 478 | 7 | 1 | 4 | 3.8 | NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL345309 | 118978 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 478 | 7 | 1 | 4 | 3.8 | NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
11071343 | 121003 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 515 | 7 | 0 | 4 | 4.9 | O=C1CCC(CCN2CC(N3CCCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL358418 | 121003 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 515 | 7 | 0 | 4 | 4.9 | O=C1CCC(CCN2CC(N3CCCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
44366283 | 39302 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8 | Binding | ChEMBL | 571 | 9 | 0 | 5 | 2.8 | CN(C)S(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL147301 | 39302 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8 | Binding | ChEMBL | 571 | 9 | 0 | 5 | 2.8 | CN(C)S(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
11103819 | 118974 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8 | Binding | ChEMBL | 577 | 8 | 0 | 4 | 6.2 | O=C1CCC(CCN2CC(N3CCOC(c4ccccc4)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL345288 | 118974 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8 | Binding | ChEMBL | 577 | 8 | 0 | 4 | 6.2 | O=C1CCC(CCN2CC(N3CCOC(c4ccccc4)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
21836558 | 120772 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8 | Binding | ChEMBL | 556 | 9 | 1 | 5 | 3.4 | CS(=O)(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL357946 | 120772 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8 | Binding | ChEMBL | 556 | 9 | 1 | 5 | 3.4 | CS(=O)(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
11123982 | 43934 | 0 | None | - | 1 | Human | 7.0 | pKd | = | 7 | Binding | ChEMBL | 502 | 7 | 0 | 5 | 3.9 | O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccncc1 | 10.1021/jm0209331 | ||
CHEMBL151621 | 43934 | 0 | None | - | 1 | Human | 7.0 | pKd | = | 7 | Binding | ChEMBL | 502 | 7 | 0 | 5 | 3.9 | O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccncc1 | 10.1021/jm0209331 | ||
44300138 | 100430 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 567 | 9 | 6 | 3 | 5.6 | N=C(N)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL293804 | 100430 | 0 | None | - | 1 | Human | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 567 | 9 | 6 | 3 | 5.6 | N=C(N)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
21836503 | 41708 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 464 | 7 | 1 | 4 | 3.2 | O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 | 10.1021/jm0209331 | ||
CHEMBL149469 | 41708 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 464 | 7 | 1 | 4 | 3.2 | O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 | 10.1021/jm0209331 | ||
44300056 | 100369 | 0 | None | - | 1 | Human | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 630 | 17 | 3 | 2 | 9.9 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL293374 | 100369 | 0 | None | - | 1 | Human | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 630 | 17 | 3 | 2 | 9.9 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL555235 | 100369 | 0 | None | - | 1 | Human | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 630 | 17 | 3 | 2 | 9.9 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
44300032 | 197416 | 0 | None | - | 1 | Human | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 525 | 8 | 4 | 3 | 6.0 | NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL58873 | 197416 | 0 | None | - | 1 | Human | 5.9 | pKd | = | 5.9 | Binding | ChEMBL | 525 | 8 | 4 | 3 | 6.0 | NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
52937467 | 62194 | 0 | None | -9 | 3 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 820 | 14 | 7 | 7 | 3.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL1782141 | 62194 | 0 | None | -9 | 3 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 820 | 14 | 7 | 7 | 3.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
21836538 | 39250 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 520 | 8 | 1 | 4 | 3.9 | CC(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL147241 | 39250 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 520 | 8 | 1 | 4 | 3.9 | CC(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
10864203 | 43451 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 514 | 7 | 0 | 4 | 4.4 | CN1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL151026 | 43451 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 514 | 7 | 0 | 4 | 4.4 | CN1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 | 10.1021/jm0209331 | ||
44300037 | 191335 | 0 | None | - | 1 | Human | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 681 | 14 | 7 | 5 | 4.6 | NC(N)=NCCC[C@H](N)C(=O)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL52004 | 191335 | 0 | None | - | 1 | Human | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 681 | 14 | 7 | 5 | 4.6 | NC(N)=NCCC[C@H](N)C(=O)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm2017072 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm2017072 | ||
71452185 | 83122 | 0 | None | -2 | 2 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 690 | 7 | 1 | 6 | 5.6 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203707 | 83122 | 0 | None | -2 | 2 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 690 | 7 | 1 | 6 | 5.6 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
44300106 | 196602 | 0 | None | - | 1 | Human | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 623 | 11 | 5 | 3 | 6.7 | CC/N=C(\NCC)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL57584 | 196602 | 0 | None | - | 1 | Human | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 623 | 11 | 5 | 3 | 6.7 | CC/N=C(\NCC)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
11135103 | 121060 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 519 | 7 | 0 | 4 | 4.6 | O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccc(F)cc1 | 10.1021/jm0209331 | ||
CHEMBL358600 | 121060 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 519 | 7 | 0 | 4 | 4.6 | O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccc(F)cc1 | 10.1021/jm0209331 | ||
11113999 | 43619 | 0 | None | - | 1 | Human | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 515 | 7 | 0 | 4 | 4.0 | O=C1CCC(CCN2CC(N3CCOCC3=O)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL151155 | 43619 | 0 | None | - | 1 | Human | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 515 | 7 | 0 | 4 | 4.0 | O=C1CCC(CCN2CC(N3CCOCC3=O)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
11763019 | 119185 | 0 | None | - | 1 | Human | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 515 | 7 | 0 | 4 | 4.8 | Cc1cccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)c1 | 10.1021/jm0209331 | ||
CHEMBL347284 | 119185 | 0 | None | - | 1 | Human | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 515 | 7 | 0 | 4 | 4.8 | Cc1cccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)c1 | 10.1021/jm0209331 | ||
44241710 | 83118 | 0 | None | 3 | 2 | Human | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 613 | 6 | 2 | 5 | 6.1 | Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203703 | 83118 | 0 | None | 3 | 2 | Human | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 613 | 6 | 2 | 5 | 6.1 | Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
44300497 | 100291 | 0 | None | - | 1 | Human | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 695 | 18 | 3 | 2 | 10.3 | CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL292816 | 100291 | 0 | None | - | 1 | Human | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 695 | 18 | 3 | 2 | 10.3 | CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
22901331 | 11876 | 0 | None | - | 1 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
54435601 | 11876 | 0 | None | - | 1 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
59922977 | 11876 | 0 | None | - | 1 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL1183068 | 11876 | 0 | None | - | 1 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
CHEMBL278294 | 11876 | 0 | None | - | 1 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 424 | 4 | 0 | 4 | 5.2 | CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 | 10.1021/jm00109a034 | ||
11071001 | 42725 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 4.1 | CN(CCO)C1CN(CCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)C1 | 10.1021/jm0209331 | ||
CHEMBL150381 | 42725 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 4.1 | CN(CCO)C1CN(CCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)C1 | 10.1021/jm0209331 | ||
44366988 | 43757 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 596 | 9 | 1 | 4 | 5.5 | CC(=O)NC1(c2ccccc2)CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL151356 | 43757 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 596 | 9 | 1 | 4 | 5.5 | CC(=O)NC1(c2ccccc2)CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
44366559 | 119026 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 557 | 9 | 1 | 5 | 2.4 | CNS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL345733 | 119026 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 557 | 9 | 1 | 5 | 2.4 | CNS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
44366577 | 120598 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 542 | 8 | 0 | 5 | 2.9 | CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL357357 | 120598 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 542 | 8 | 0 | 5 | 2.9 | CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
52937271 | 62192 | 0 | None | - | 1 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 515 | 5 | 1 | 3 | 3.8 | CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL1782139 | 62192 | 0 | None | - | 1 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 515 | 5 | 1 | 3 | 3.8 | CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
118730933 | 117654 | 0 | None | -389 | 2 | Human | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 698 | 15 | 7 | 7 | 1.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408519 | 117654 | 0 | None | -389 | 2 | Human | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 698 | 15 | 7 | 7 | 1.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
6604943 | 101270 | 1 | None | - | 1 | Human | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 712 | 18 | 3 | 2 | 11.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL299701 | 101270 | 1 | None | - | 1 | Human | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 712 | 18 | 3 | 2 | 11.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL555236 | 101270 | 1 | None | - | 1 | Human | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 712 | 18 | 3 | 2 | 11.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
44300034 | 196828 | 0 | None | - | 1 | Human | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 569 | 9 | 5 | 4 | 5.7 | NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)c(C(=O)O)c1 | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL57778 | 196828 | 0 | None | - | 1 | Human | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 569 | 9 | 5 | 4 | 5.7 | NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)c(C(=O)O)c1 | 10.1016/S0960-894X(97)00328-4 | ||
71457524 | 83120 | 0 | None | -5 | 2 | Human | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 597 | 6 | 1 | 4 | 7.1 | Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203705 | 83120 | 0 | None | -5 | 2 | Human | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 597 | 6 | 1 | 4 | 7.1 | Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
10864032 | 43454 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 500 | 7 | 1 | 4 | 4.0 | O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
CHEMBL151028 | 43454 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 500 | 7 | 1 | 4 | 4.0 | O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 | 10.1021/jm0209331 | ||
21836496 | 120379 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 507 | 7 | 1 | 4 | 3.0 | NC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL355973 | 120379 | 0 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 507 | 7 | 1 | 4 | 3.0 | NC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm2017072 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm2017072 | ||
118730934 | 117655 | 0 | None | -363 | 2 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 835 | 15 | 6 | 7 | 4.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408520 | 117655 | 0 | None | -363 | 2 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 835 | 15 | 6 | 7 | 4.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
44300055 | 100536 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 695 | 18 | 3 | 2 | 10.3 | CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL294452 | 100536 | 0 | None | - | 1 | Human | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 695 | 18 | 3 | 2 | 10.3 | CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
11813288 | 43028 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 515 | 7 | 0 | 4 | 4.8 | Cc1ccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)cc1 | 10.1021/jm0209331 | ||
CHEMBL150644 | 43028 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 515 | 7 | 0 | 4 | 4.8 | Cc1ccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)cc1 | 10.1021/jm0209331 | ||
44366742 | 43714 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 507 | 9 | 0 | 4 | 4.8 | CCOC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
CHEMBL151288 | 43714 | 0 | None | - | 1 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 507 | 9 | 0 | 4 | 4.8 | CCOC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 | 10.1021/jm0209331 | ||
11103197 | 78004 | 0 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 507 | 7 | 0 | 4 | 4.8 | O=C1CC[C@@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 | 10.1021/jm0209331 | ||
CHEMBL2111193 | 78004 | 0 | None | - | 1 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 507 | 7 | 0 | 4 | 4.8 | O=C1CC[C@@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 | 10.1021/jm0209331 | ||
132927 | 4021 | 3 | None | -6 | 2 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 10.1016/S0960-894X(97)00328-4 | ||
138398059 | 4021 | 3 | None | -6 | 2 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 10.1016/S0960-894X(97)00328-4 | ||
677 | 4021 | 3 | None | -6 | 2 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL294453 | 4021 | 3 | None | -6 | 2 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL551291 | 4021 | 3 | None | -6 | 2 | Human | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 10.1016/S0960-894X(97)00328-4 | ||
9847362 | 121175 | 0 | None | - | 1 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 465 | 7 | 0 | 4 | 3.7 | O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 | 10.1021/jm0209331 | ||
CHEMBL358694 | 121175 | 0 | None | - | 1 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 465 | 7 | 0 | 4 | 3.7 | O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 | 10.1021/jm0209331 | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
230 | 444 | 80 | None | 50 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
44300139 | 197365 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 567 | 9 | 6 | 3 | 5.6 | N=C(N)NCc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
CHEMBL58598 | 197365 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 567 | 9 | 6 | 3 | 5.6 | N=C(N)NCc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 | 10.1016/S0960-894X(97)00328-4 | ||
118730932 | 117653 | 0 | None | -2951 | 2 | Human | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 834 | 15 | 7 | 7 | 3.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408518 | 117653 | 0 | None | -2951 | 2 | Human | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 834 | 15 | 7 | 7 | 3.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
25129133 | 188300 | 0 | None | 102 | 5 | Human | 11.2 | pKi | = | 11.2 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800389v | ||
CHEMBL507340 | 188300 | 0 | None | 102 | 5 | Human | 11.2 | pKi | = | 11.2 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800389v | ||
10288987 | 18030 | 0 | None | - | 1 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.6 | CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | nan | ||
CHEMBL1270066 | 18030 | 0 | None | - | 1 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.6 | CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | nan | ||
122187724 | 122550 | 0 | None | 17 | 4 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 692 | 11 | 5 | 6 | 5.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
CHEMBL3609620 | 122550 | 0 | None | 17 | 4 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 692 | 11 | 5 | 6 | 5.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
10216430 | 79495 | 0 | None | 204173 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.9 | C[C@@H](OCC1(c2ccccc2)CC(N)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL212428 | 79495 | 0 | None | 204173 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.9 | C[C@@H](OCC1(c2ccccc2)CC(N)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
5752 | 3942 | 20 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1016/j.bmc.2011.08.070 | ||
6918331 | 3942 | 20 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1016/j.bmc.2011.08.070 | ||
CHEMBL522302 | 3942 | 20 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1016/j.bmc.2011.08.070 | ||
DB12436 | 3942 | 20 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1016/j.bmc.2011.08.070 | ||
5752 | 3942 | 20 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1016/0960-894X(96)00163-1 | ||
6918331 | 3942 | 20 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL522302 | 3942 | 20 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1016/0960-894X(96)00163-1 | ||
DB12436 | 3942 | 20 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL3609617 | 210084 | 0 | None | 501 | 4 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||||
10714695 | 41791 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 378 | 6 | 2 | 4 | 5.0 | COc1ccc(-c2ccsc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL149557 | 41791 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 378 | 6 | 2 | 4 | 5.0 | COc1ccc(-c2ccsc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
9852175 | 77839 | 13 | None | 1 | 3 | Mongolian jird | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 628 | 4 | 0 | 3 | 6.8 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL2105667 | 77839 | 13 | None | 1 | 3 | Mongolian jird | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 628 | 4 | 0 | 3 | 6.8 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL2419537 | 208693 | 0 | None | 32 | 4 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
44264764 | 13076 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 3.2 | CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL1191008 | 13076 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 3.2 | CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL542044 | 13076 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 3.2 | CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 | 10.1016/0960-894X(96)00163-1 | ||
22880695 | 13475 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 410 | 7 | 2 | 8 | 3.0 | COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL1194085 | 13475 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 410 | 7 | 2 | 8 | 3.0 | COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL545594 | 13475 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 410 | 7 | 2 | 8 | 3.0 | COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
127944 | 120412 | 2 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL356062 | 120412 | 2 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL555572 | 120412 | 2 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL3608939 | 210081 | 0 | None | 1 | 3 | Rat | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||||
CHEMBL261390 | 208773 | 0 | None | 34 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm070332f | ||||
44177770 | 122486 | 0 | None | 31 | 4 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 939 | 20 | 8 | 9 | 4.1 | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
CHEMBL3608937 | 122486 | 0 | None | 31 | 4 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 939 | 20 | 8 | 9 | 4.1 | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
10500669 | 38840 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 391 | 6 | 2 | 5 | 4.6 | COc1ccc(-c2c(C)noc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL146885 | 38840 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 391 | 6 | 2 | 5 | 4.6 | COc1ccc(-c2c(C)noc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
10809458 | 118882 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 374 | 5 | 2 | 3 | 4.0 | COc1ccc(Br)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL344536 | 118882 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 374 | 5 | 2 | 3 | 4.0 | COc1ccc(Br)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
127944 | 120412 | 2 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL356062 | 120412 | 2 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL555572 | 120412 | 2 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
5752 | 3942 | 20 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1021/jm900023b | ||
6918331 | 3942 | 20 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1021/jm900023b | ||
CHEMBL522302 | 3942 | 20 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1021/jm900023b | ||
DB12436 | 3942 | 20 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 10.1021/jm900023b | ||
44264847 | 12713 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 378 | 6 | 2 | 7 | 2.6 | COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL1188354 | 12713 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 378 | 6 | 2 | 7 | 2.6 | COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL536103 | 12713 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 378 | 6 | 2 | 7 | 2.6 | COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
44264766 | 13444 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 392 | 7 | 2 | 7 | 2.8 | CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL1193883 | 13444 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 392 | 7 | 2 | 7 | 2.8 | CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL545360 | 13444 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 392 | 7 | 2 | 7 | 2.8 | CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 | 10.1016/0960-894X(96)00163-1 | ||
45271306 | 193999 | 0 | None | 14 | 4 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 1438 | 33 | 14 | 16 | 3.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL556537 | 193999 | 0 | None | 14 | 4 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 1438 | 33 | 14 | 16 | 3.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
11793012 | 120534 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 362 | 6 | 2 | 4 | 4.5 | COc1ccc(-c2ccoc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL356786 | 120534 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 362 | 6 | 2 | 4 | 4.5 | COc1ccc(-c2ccoc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
10499614 | 121464 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 373 | 6 | 2 | 4 | 4.3 | COc1ccc(-c2ccncc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL359188 | 121464 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 373 | 6 | 2 | 4 | 4.3 | COc1ccc(-c2ccncc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
9852175 | 77839 | 13 | None | -1 | 3 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 628 | 4 | 0 | 3 | 6.8 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL2105667 | 77839 | 13 | None | -1 | 3 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 628 | 4 | 0 | 3 | 6.8 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
22880684 | 13384 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 442 | 7 | 2 | 9 | 1.7 | COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL1193478 | 13384 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 442 | 7 | 2 | 9 | 1.7 | COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL544891 | 13384 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 442 | 7 | 2 | 9 | 1.7 | COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
24969015 | 92545 | 3 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 628 | 4 | 0 | 3 | 6.8 | Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL2441373 | 92545 | 3 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 628 | 4 | 0 | 3 | 6.8 | Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL2419538 | 208694 | 0 | None | 75 | 4 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC1(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCC1 | 10.1016/j.bmcl.2013.06.065 | ||||
44177570 | 60931 | 0 | None | 15 | 4 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1219 | 27 | 10 | 10 | 6.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766204 | 60931 | 0 | None | 15 | 4 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1219 | 27 | 10 | 10 | 6.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
44233185 | 193154 | 0 | None | 47 | 4 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1327 | 29 | 14 | 16 | 1.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL539193 | 193154 | 0 | None | 47 | 4 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1327 | 29 | 14 | 16 | 1.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2013.12.033 | ||
230 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2013.12.033 | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2013.12.033 | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2013.12.033 | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2013.12.033 | ||
10641076 | 167853 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 342 | 6 | 2 | 4 | 4.0 | COc1ccc(SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL434884 | 167853 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 342 | 6 | 2 | 4 | 4.0 | COc1ccc(SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
10152974 | 57562 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 519 | 4 | 0 | 2 | 6.5 | Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL1672044 | 57562 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 519 | 4 | 0 | 2 | 6.5 | Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
15463537 | 13884 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 404 | 7 | 2 | 7 | 3.1 | COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL1197007 | 13884 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 404 | 7 | 2 | 7 | 3.1 | COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL558990 | 13884 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 404 | 7 | 2 | 7 | 3.1 | COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
51002938 | 57565 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 531 | 4 | 0 | 2 | 6.6 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL1672047 | 57565 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 531 | 4 | 0 | 2 | 6.6 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL389652 | 210683 | 0 | None | 2 | 4 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
CHEMBL389652 | 210683 | 0 | None | 2 | 4 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800389v | ||||
CHEMBL2419542 | 208698 | 0 | None | 6 | 3 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
CHEMBL2419541 | 208697 | 0 | None | 3 | 4 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
CHEMBL2419543 | 208699 | 0 | None | 16 | 4 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
9871118 | 145599 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 514 | 6 | 2 | 5 | 5.2 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](n2cn[nH]c2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
CHEMBL3919618 | 145599 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 514 | 6 | 2 | 5 | 5.2 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](n2cn[nH]c2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
2109 | 4073 | 3 | None | 5 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 631 | 9 | 0 | 4 | 7.9 | N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C | 10.1016/s0960-894x(01)00572-8 | ||
9852253 | 4073 | 3 | None | 5 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 631 | 9 | 0 | 4 | 7.9 | N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C | 10.1016/s0960-894x(01)00572-8 | ||
CHEMBL129683 | 4073 | 3 | None | 5 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 631 | 9 | 0 | 4 | 7.9 | N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C | 10.1016/s0960-894x(01)00572-8 | ||
10173872 | 138743 | 0 | None | 6309 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 6.0 | CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL379072 | 138743 | 0 | None | 6309 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 6.0 | CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2006.04.031 | ||
46227362 | 200897 | 0 | None | 12 | 4 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL611926 | 200897 | 0 | None | 12 | 4 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
51002993 | 57571 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 602 | 4 | 0 | 3 | 6.1 | CC(=O)N1CCN([C@H]2CCN(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 | 10.1021/jm1013264 | ||
CHEMBL1672053 | 57571 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 602 | 4 | 0 | 3 | 6.1 | CC(=O)N1CCN([C@H]2CCN(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 | 10.1021/jm1013264 | ||
CHEMBL3609616 | 210083 | 0 | None | 1 | 4 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||||
CHEMBL2419539 | 208695 | 0 | None | 25 | 4 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
2109 | 4073 | 3 | None | 5 | 3 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 631 | 9 | 0 | 4 | 7.9 | N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C | 10.1021/jm020094i | ||
9852253 | 4073 | 3 | None | 5 | 3 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 631 | 9 | 0 | 4 | 7.9 | N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C | 10.1021/jm020094i | ||
CHEMBL129683 | 4073 | 3 | None | 5 | 3 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 631 | 9 | 0 | 4 | 7.9 | N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C | 10.1021/jm020094i | ||
10546738 | 165056 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2ncnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL424301 | 165056 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.3 | COc1ccc(-n2ncnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
23725089 | 791 | 8 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 10.1021/jm1013264 | ||
4401 | 791 | 8 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 10.1021/jm1013264 | ||
5758 | 791 | 8 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 10.1021/jm1013264 | ||
9917021 | 791 | 8 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 10.1021/jm1013264 | ||
CHEMBL1672054 | 791 | 8 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 10.1021/jm1013264 | ||
DB06634 | 791 | 8 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 10.1021/jm1013264 | ||
72203985 | 92543 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 628 | 4 | 0 | 3 | 6.8 | Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL2441371 | 92543 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 628 | 4 | 0 | 3 | 6.8 | Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL1651026 | 207083 | 19 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O | 10.1016/j.ejmech.2013.01.044 | ||||
9961315 | 117421 | 0 | None | 2 | 3 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 661 | 10 | 0 | 5 | 7.9 | COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 | 10.1021/jm020094i | ||
CHEMBL340326 | 117421 | 0 | None | 2 | 3 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 661 | 10 | 0 | 5 | 7.9 | COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 | 10.1021/jm020094i | ||
51003118 | 57569 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 559 | 4 | 0 | 2 | 7.6 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL1672051 | 57569 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 559 | 4 | 0 | 2 | 7.6 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL3609616 | 210083 | 0 | None | -1 | 4 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||||
10288987 | 18030 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.6 | CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270066 | 18030 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.6 | CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
10495476 | 39671 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 314 | 5 | 2 | 3 | 3.4 | COc1ccc(F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL147776 | 39671 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 314 | 5 | 2 | 3 | 3.4 | COc1ccc(F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
10643148 | 121030 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 374 | 6 | 2 | 5 | 3.7 | COc1ccc(-c2cncnc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL358575 | 121030 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 374 | 6 | 2 | 5 | 3.7 | COc1ccc(-c2cncnc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
10784942 | 121476 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 363 | 6 | 2 | 6 | 2.9 | COc1ccc(-n2cncn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL359255 | 121476 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 363 | 6 | 2 | 6 | 2.9 | COc1ccc(-n2cncn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
51002996 | 57575 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 559 | 5 | 1 | 2 | 7.6 | Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL1672058 | 57575 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 559 | 5 | 1 | 2 | 7.6 | Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
2102 | 1166 | 17 | None | 2 | 2 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00073a022 | ||
5311057 | 1166 | 17 | None | 2 | 2 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00073a022 | ||
CHEMBL441225 | 1166 | 17 | None | 2 | 2 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00073a022 | ||
105083 | 25247 | 3 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 | 10.1021/jm00051a001 | ||
CHEMBL135022 | 25247 | 3 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 | 10.1021/jm00051a001 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00104a018 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00104a018 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00104a018 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00481-8 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00481-8 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00481-8 | ||
9809876 | 19202 | 1 | None | 398 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 661 | 10 | 0 | 5 | 7.9 | COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm020094i | ||
CHEMBL129321 | 19202 | 1 | None | 398 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 661 | 10 | 0 | 5 | 7.9 | COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm020094i | ||
51003056 | 57566 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 545 | 4 | 0 | 2 | 7.2 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL1672048 | 57566 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 545 | 4 | 0 | 2 | 7.2 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
49863732 | 15158 | 0 | None | 24 | 4 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1266 | 18 | 10 | 12 | 6.1 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm100157m | ||
CHEMBL1214025 | 15158 | 0 | None | 24 | 4 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1266 | 18 | 10 | 12 | 6.1 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm100157m | ||
10217362 | 18110 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.2 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270565 | 18110 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.2 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
10547681 | 120565 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 378 | 6 | 2 | 7 | 2.5 | COc1ccc(-c2nnnn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL357029 | 120565 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 378 | 6 | 2 | 7 | 2.5 | COc1ccc(-c2nnnn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
21041073 | 138320 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 667 | 11 | 1 | 6 | 6.1 | C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL378156 | 138320 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 667 | 11 | 1 | 6 | 6.1 | C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
51003119 | 57570 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 559 | 4 | 0 | 2 | 7.6 | Cc1cc(F)ccc1[C@H]1C[C@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL1672052 | 57570 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 559 | 4 | 0 | 2 | 7.6 | Cc1cc(F)ccc1[C@H]1C[C@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
53320128 | 57573 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 505 | 4 | 1 | 2 | 6.1 | CN[C@H]1CCN(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 | 10.1021/jm1013264 | ||
CHEMBL1672056 | 57573 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 505 | 4 | 1 | 2 | 6.1 | CN[C@H]1CCN(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 | 10.1021/jm1013264 | ||
10290124 | 92544 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 628 | 4 | 0 | 3 | 6.8 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
CHEMBL2441372 | 92544 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 628 | 4 | 0 | 3 | 6.8 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2013.09.001 | ||
10289148 | 146579 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 502 | 5 | 2 | 4 | 5.6 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@]2(CN1)COC(=O)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
CHEMBL3927453 | 146579 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 502 | 5 | 2 | 4 | 5.6 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@]2(CN1)COC(=O)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
CHEMBL3609618 | 210085 | 0 | None | 16 | 4 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||||
44560810 | 172704 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 528 | 6 | 1 | 3 | 5.6 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL452534 | 172704 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 528 | 6 | 1 | 3 | 5.6 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
9958115 | 172927 | 0 | None | 6309 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 514 | 6 | 1 | 3 | 5.2 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL453054 | 172927 | 0 | None | 6309 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 514 | 6 | 1 | 3 | 5.2 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
44560811 | 188406 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 528 | 6 | 1 | 3 | 5.6 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL508661 | 188406 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 528 | 6 | 1 | 3 | 5.6 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
11327981 | 181696 | 12 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 434 | 5 | 2 | 4 | 4.6 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@](C)(C(F)(F)F)OCC2 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL478392 | 181696 | 12 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 434 | 5 | 2 | 4 | 4.6 | COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@](C)(C(F)(F)F)OCC2 | 10.1016/j.bmc.2008.06.047 | ||
CHEMBL229280 | 207713 | 0 | None | 23 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC[S+](C)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
51003053 | 57576 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 563 | 7 | 1 | 3 | 6.7 | COCCN[C@H]1CCN(C(=O)N(C)[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 | 10.1021/jm1013264 | ||
CHEMBL1672059 | 57576 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 563 | 7 | 1 | 3 | 6.7 | COCCN[C@H]1CCN(C(=O)N(C)[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 | 10.1021/jm1013264 | ||
44177669 | 60932 | 0 | None | 2 | 4 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1233 | 27 | 9 | 10 | 6.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766205 | 60932 | 0 | None | 2 | 4 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1233 | 27 | 9 | 10 | 6.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
10217361 | 18109 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.2 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270564 | 18109 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.2 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
5757 | 3923 | 10 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1021/jm1013264 | ||
9832383 | 3923 | 10 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1021/jm1013264 | ||
CHEMBL522987 | 3923 | 10 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1021/jm1013264 | ||
DB11949 | 3923 | 10 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1021/jm1013264 | ||
5757 | 3923 | 10 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1021/jm900023b | ||
9832383 | 3923 | 10 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1021/jm900023b | ||
CHEMBL522987 | 3923 | 10 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1021/jm900023b | ||
DB11949 | 3923 | 10 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1021/jm900023b | ||
10289302 | 18050 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 2 | 3 | 6.0 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(=O)C2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270175 | 18050 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 2 | 3 | 6.0 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(=O)C2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
9872808 | 57563 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 533 | 4 | 0 | 2 | 7.1 | Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL1672045 | 57563 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 533 | 4 | 0 | 2 | 7.1 | Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
46227363 | 197984 | 0 | None | 28 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL592969 | 197984 | 0 | None | 28 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
5757 | 3923 | 10 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1016/j.bmcl.2009.11.078 | ||
9832383 | 3923 | 10 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1016/j.bmcl.2009.11.078 | ||
CHEMBL522987 | 3923 | 10 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1016/j.bmcl.2009.11.078 | ||
DB11949 | 3923 | 10 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 10.1016/j.bmcl.2009.11.078 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00207-A | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00207-A | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00207-A | ||
10598278 | 13811 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 421 | 7 | 3 | 8 | 2.2 | COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL1196442 | 13811 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 421 | 7 | 3 | 8 | 2.2 | COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL556981 | 13811 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 421 | 7 | 3 | 8 | 2.2 | COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
52943331 | 18065 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 6 | 1 | 3 | 6.1 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCCC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270271 | 18065 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 6 | 1 | 3 | 6.1 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCCC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
52947014 | 18122 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.4 | CNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270664 | 18122 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.4 | CNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
2102 | 1166 | 17 | None | 2 | 2 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00073a022 | ||
5311057 | 1166 | 17 | None | 2 | 2 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00073a022 | ||
CHEMBL441225 | 1166 | 17 | None | 2 | 2 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00073a022 | ||
9852904 | 116536 | 0 | None | 34 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 677 | 10 | 1 | 6 | 5.9 | CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm020094i | ||
CHEMBL339051 | 116536 | 0 | None | 34 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 677 | 10 | 1 | 6 | 5.9 | CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm020094i | ||
51002992 | 57568 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 545 | 4 | 0 | 2 | 7.0 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL1672050 | 57568 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 545 | 4 | 0 | 2 | 7.0 | Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
122187724 | 122550 | 0 | None | -17 | 4 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 692 | 11 | 5 | 6 | 5.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
CHEMBL3609620 | 122550 | 0 | None | -17 | 4 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 692 | 11 | 5 | 6 | 5.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
52940937 | 18093 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 515 | 6 | 2 | 5 | 5.4 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC2=NCCO2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270465 | 18093 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 515 | 6 | 2 | 5 | 5.4 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC2=NCCO2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
10152358 | 18049 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 502 | 7 | 2 | 3 | 6.0 | CCC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270174 | 18049 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 502 | 7 | 2 | 3 | 6.0 | CCC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL389652 | 210683 | 0 | None | 2 | 4 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
CHEMBL389652 | 210683 | 0 | None | -2 | 4 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800389v | ||||
CHEMBL2419541 | 208697 | 0 | None | -3 | 4 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
CHEMBL389652 | 210683 | 0 | None | -2 | 4 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
153996 | 112171 | 2 | None | 3 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(01)00572-8 | ||
CHEMBL330366 | 112171 | 2 | None | 3 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(01)00572-8 | ||
CHEMBL539021 | 112171 | 2 | None | 3 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.7 | COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(01)00572-8 | ||
9831546 | 203464 | 0 | None | -1 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 698 | 12 | 1 | 6 | 5.6 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL78284 | 203464 | 0 | None | -1 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 698 | 12 | 1 | 6 | 5.6 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL2397481 | 208671 | 5 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||||
11712457 | 18166 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 6.5 | C[C@@H](OC[C@@]1(c2ccccc2)CCCCN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270970 | 18166 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 6.5 | C[C@@H](OC[C@@]1(c2ccccc2)CCCCN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL2397481 | 208671 | 5 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2018.06.009 | ||||
10128086 | 79416 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 485 | 6 | 0 | 2 | 6.5 | C[C@@H](OC[C@]1(c2ccccc2)C[C@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL212112 | 79416 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 485 | 6 | 0 | 2 | 6.5 | C[C@@H](OC[C@]1(c2ccccc2)C[C@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
10128366 | 79854 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 507 | 8 | 1 | 2 | 7.7 | C[C@@H](OCC1(c2ccccc2)CC(NCc2ccccc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL213906 | 79854 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 507 | 8 | 1 | 2 | 7.7 | C[C@@H](OCC1(c2ccccc2)CC(NCc2ccccc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
10128322 | 172403 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 502 | 7 | 2 | 3 | 5.1 | CCC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL451765 | 172403 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 502 | 7 | 2 | 3 | 5.1 | CCC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.05.082 | ||
10311126 | 172628 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 4.7 | CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL452270 | 172628 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 4.7 | CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.05.082 | ||
44560775 | 172702 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 502 | 7 | 2 | 3 | 5.1 | CCC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL452532 | 172702 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 502 | 7 | 2 | 3 | 5.1 | CCC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.05.082 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm2017072 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm2017072 | ||
44241723 | 83119 | 0 | None | 12 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 674 | 6 | 0 | 5 | 6.6 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203704 | 83119 | 0 | None | 12 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 674 | 6 | 0 | 5 | 6.6 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
10603544 | 110075 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 592 | 9 | 2 | 5 | 5.0 | COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL325312 | 110075 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 592 | 9 | 2 | 5 | 5.0 | COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
51002995 | 57574 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 545 | 5 | 1 | 2 | 7.2 | Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL1672057 | 57574 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 545 | 5 | 1 | 2 | 7.2 | Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
52945787 | 18092 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 524 | 7 | 2 | 5 | 6.4 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](Nc2ncccn2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270464 | 18092 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 524 | 7 | 2 | 5 | 6.4 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](Nc2ncccn2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
23725089 | 791 | 8 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 10.1021/jm1013264 | ||
4401 | 791 | 8 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 10.1021/jm1013264 | ||
5758 | 791 | 8 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 10.1021/jm1013264 | ||
9917021 | 791 | 8 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 10.1021/jm1013264 | ||
CHEMBL1672054 | 791 | 8 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 10.1021/jm1013264 | ||
DB06634 | 791 | 8 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 10.1021/jm1013264 | ||
122187205 | 122487 | 0 | None | 1 | 4 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 981 | 22 | 8 | 9 | 5.3 | CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
CHEMBL3608938 | 122487 | 0 | None | 1 | 4 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 981 | 22 | 8 | 9 | 5.3 | CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
52942011 | 18152 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 514 | 7 | 2 | 3 | 6.0 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270868 | 18152 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 514 | 7 | 2 | 3 | 6.0 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
52943450 | 18031 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.6 | CC(=O)N[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270067 | 18031 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.6 | CC(=O)N[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
52946917 | 18137 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 502 | 7 | 2 | 3 | 5.8 | CCNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270766 | 18137 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 502 | 7 | 2 | 3 | 5.8 | CCNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
10174642 | 146015 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 516 | 5 | 2 | 4 | 5.9 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCOC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
CHEMBL3922759 | 146015 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 516 | 5 | 2 | 4 | 5.9 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCOC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00581-D | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00581-D | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00581-D | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00552-5 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00552-5 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00552-5 | ||
44408025 | 75562 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 653 | 10 | 1 | 6 | 5.7 | C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL204979 | 75562 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 653 | 10 | 1 | 6 | 5.7 | C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
10363623 | 84455 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 400 | 7 | 2 | 4 | 4.5 | COc1ccc(C(=O)c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00207-A | ||
CHEMBL22360 | 84455 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 400 | 7 | 2 | 4 | 4.5 | COc1ccc(C(=O)c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00207-A | ||
15463538 | 13794 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 3.9 | COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL1196327 | 13794 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 3.9 | COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL556562 | 13794 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 3.9 | COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
102023780 | 120235 | 0 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 698 | 12 | 3 | 7 | 6.4 | CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
10417302 | 120235 | 0 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 698 | 12 | 3 | 7 | 6.4 | CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380072 | 120235 | 0 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 698 | 12 | 3 | 7 | 6.4 | CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL355041 | 120235 | 0 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 698 | 12 | 3 | 7 | 6.4 | CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
9852630 | 203145 | 0 | None | 1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 655 | 10 | 0 | 5 | 6.8 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL75598 | 203145 | 0 | None | 1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 655 | 10 | 0 | 5 | 6.8 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
22960738 | 74934 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 533 | 6 | 1 | 3 | 5.4 | CN1CCC(N2CC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccc(F)cc3)NC2=O)CC1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL203716 | 74934 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 533 | 6 | 1 | 3 | 5.4 | CN1CCC(N2CC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccc(F)cc3)NC2=O)CC1 | 10.1016/j.bmcl.2005.10.072 | ||
10164354 | 165448 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 507 | 7 | 2 | 3 | 4.3 | C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(CC(N)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL425406 | 165448 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 507 | 7 | 2 | 3 | 4.3 | C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(CC(N)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
18403344 | 140383 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 579 | 5 | 1 | 4 | 7.0 | Cc1ccccc1-c1cc(N2CCC(O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL382242 | 140383 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 579 | 5 | 1 | 4 | 7.0 | Cc1ccccc1-c1cc(N2CCC(O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
52942012 | 18153 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 514 | 7 | 2 | 3 | 6.0 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270869 | 18153 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 514 | 7 | 2 | 3 | 6.0 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
10173872 | 138744 | 0 | None | 5370 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 6.0 | CC(=O)N[C@H]1C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL379073 | 138744 | 0 | None | 5370 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 6.0 | CC(=O)N[C@H]1C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2006.04.031 | ||
10128086 | 138994 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 485 | 6 | 0 | 2 | 6.5 | C[C@@H](OC[C@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL379520 | 138994 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 485 | 6 | 0 | 2 | 6.5 | C[C@@H](OC[C@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
44560832 | 176239 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 500 | 6 | 1 | 3 | 5.7 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL460890 | 176239 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 500 | 6 | 1 | 3 | 5.7 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
44560834 | 189404 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 446 | 5 | 2 | 3 | 4.5 | C[C@@H](OC[C@@]1(c2ccccc2)CC(N)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL517121 | 189404 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 446 | 5 | 2 | 3 | 4.5 | C[C@@H](OC[C@@]1(c2ccccc2)CC(N)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm2017072 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm2017072 | ||
11490769 | 83123 | 0 | None | 6 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 660 | 6 | 0 | 5 | 6.3 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203708 | 83123 | 0 | None | 6 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 660 | 6 | 0 | 5 | 6.3 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
9874473 | 41564 | 0 | None | 16 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 659 | 10 | 0 | 4 | 8.4 | CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm030197g | ||
CHEMBL149326 | 41564 | 0 | None | 16 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 659 | 10 | 0 | 4 | 8.4 | CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm030197g | ||
44307758 | 201862 | 0 | None | 1 | 2 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 697 | 12 | 1 | 6 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL66635 | 201862 | 0 | None | 1 | 2 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 697 | 12 | 1 | 6 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
10311483 | 144340 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 514 | 5 | 2 | 3 | 6.1 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCCC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
CHEMBL3909899 | 144340 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 514 | 5 | 2 | 3 | 6.1 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCCC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
CHEMBL2370435 | 208104 | 0 | None | 48 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O | 10.1021/jm8007618 | ||||
44140365 | 186456 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 477 | 3 | 1 | 2 | 5.4 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
CHEMBL490926 | 186456 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 477 | 3 | 1 | 2 | 5.4 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
10173890 | 77860 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 460 | 6 | 2 | 3 | 4.7 | C[C@@H](OC[C@]1(c2ccccc2)C[C@@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL210641 | 77860 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 460 | 6 | 2 | 3 | 4.7 | C[C@@H](OC[C@]1(c2ccccc2)C[C@@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
51003178 | 57572 | 3 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | CC(=O)N1CCN([C@@H]2CCN(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 | 10.1021/jm1013264 | ||
CHEMBL1672055 | 57572 | 3 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 616 | 4 | 0 | 3 | 6.7 | CC(=O)N1CCN([C@@H]2CCN(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 | 10.1021/jm1013264 | ||
9873032 | 75032 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 579 | 5 | 0 | 5 | 6.2 | Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL203867 | 75032 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 579 | 5 | 0 | 5 | 6.2 | Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL3609615 | 210082 | 0 | None | -2 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00104a018 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00104a018 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00104a018 | ||
44380081 | 57801 | 0 | None | 100 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 738 | 13 | 1 | 7 | 6.3 | CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL167546 | 57801 | 0 | None | 100 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 738 | 13 | 1 | 7 | 6.3 | CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
9810434 | 103904 | 0 | None | 1 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 713 | 12 | 1 | 6 | 6.9 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL310273 | 103904 | 0 | None | 1 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 713 | 12 | 1 | 6 | 6.9 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44407938 | 139916 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 446 | 5 | 1 | 2 | 5.4 | C[C@@H](OC[C@@]1(c2ccccc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL380931 | 139916 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 446 | 5 | 1 | 2 | 5.4 | C[C@@H](OC[C@@]1(c2ccccc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
52937467 | 62194 | 0 | None | -9 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 820 | 14 | 7 | 7 | 3.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL1782141 | 62194 | 0 | None | -9 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 820 | 14 | 7 | 7 | 3.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
52937467 | 62194 | 0 | None | -9 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 820 | 14 | 7 | 7 | 3.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL1782141 | 62194 | 0 | None | -9 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 820 | 14 | 7 | 7 | 3.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
52937467 | 62194 | 0 | None | -9 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 820 | 14 | 7 | 7 | 3.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm1016285 | ||
CHEMBL1782141 | 62194 | 0 | None | -9 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 820 | 14 | 7 | 7 | 3.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm1016285 | ||
135416054 | 79814 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 514 | 8 | 3 | 5 | 5.5 | C[C@@H](OCC1(c2ccccc2)CC(NCc2n[nH]c(O)n2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL213735 | 79814 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 514 | 8 | 3 | 5 | 5.5 | C[C@@H](OCC1(c2ccccc2)CC(NCc2n[nH]c(O)n2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
10151946 | 79910 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.0 | CNC(=O)[C@]1(N)C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL214194 | 79910 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.0 | CNC(=O)[C@]1(N)C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2006.04.031 | ||
44560809 | 172928 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 514 | 6 | 1 | 3 | 5.2 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL453055 | 172928 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 514 | 6 | 1 | 3 | 5.2 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
44560833 | 176278 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 447 | 5 | 2 | 3 | 4.6 | C[C@@H](OC[C@@]1(c2ccccc2)CC(O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL461299 | 176278 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 447 | 5 | 2 | 3 | 4.6 | C[C@@H](OC[C@@]1(c2ccccc2)CC(O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
44241723 | 83119 | 0 | None | 12 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 674 | 6 | 0 | 5 | 6.6 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203704 | 83119 | 0 | None | 12 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 674 | 6 | 0 | 5 | 6.6 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
10698493 | 109291 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 581 | 9 | 3 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL323224 | 109291 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 581 | 9 | 3 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl | 10.1021/jm970499g | ||
10522676 | 118656 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 6 | 2 | 4 | 4.5 | COc1ccc(-c2ccco2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL342966 | 118656 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 6 | 2 | 4 | 4.5 | COc1ccc(-c2ccco2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
10761962 | 118721 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 374 | 6 | 2 | 5 | 2.7 | COc1ccc(S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL343404 | 118721 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 374 | 6 | 2 | 5 | 2.7 | COc1ccc(S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
24969353 | 197468 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 503 | 3 | 1 | 2 | 5.9 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)C1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 | 10.1016/j.bmcl.2009.11.078 | ||
CHEMBL589371 | 197468 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 503 | 3 | 1 | 2 | 5.9 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)C1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 | 10.1016/j.bmcl.2009.11.078 | ||
46224928 | 197721 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 515 | 2 | 1 | 2 | 6.2 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
CHEMBL591074 | 197721 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 515 | 2 | 1 | 2 | 6.2 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
46889695 | 6851 | 0 | None | 2 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 615 | 6 | 2 | 5 | 6.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@@H](O)C[C@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1084436 | 6851 | 0 | None | 2 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 615 | 6 | 2 | 5 | 6.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@@H](O)C[C@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
104974 | 3419 | 27 | None | -1 | 7 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/S0960-894X(01)80901-X | ||
2111 | 3419 | 27 | None | -1 | 7 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/S0960-894X(01)80901-X | ||
3481 | 3419 | 27 | None | -1 | 7 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/S0960-894X(01)80901-X | ||
CHEMBL308148 | 3419 | 27 | None | -1 | 7 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/S0960-894X(01)80901-X | ||
DB06660 | 3419 | 27 | None | -1 | 7 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 10.1016/S0960-894X(01)80901-X | ||
46227361 | 200896 | 0 | None | 14 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL611925 | 200896 | 0 | None | 14 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
11261795 | 197025 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
CHEMBL492117 | 197025 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
CHEMBL581391 | 197025 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
52943348 | 18123 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.4 | CNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270665 | 18123 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 5.4 | CNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
10462 | 1985 | 7 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 550 | 5 | 0 | 4 | 6.1 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2005.11.047 | ||
9808518 | 1985 | 7 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 550 | 5 | 0 | 4 | 6.1 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL206488 | 1985 | 7 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 550 | 5 | 0 | 4 | 6.1 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1016/j.bmcl.2005.11.047 | ||
122187205 | 122487 | 0 | None | -1 | 4 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 981 | 22 | 8 | 9 | 5.3 | CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
CHEMBL3608938 | 122487 | 0 | None | -1 | 4 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 981 | 22 | 8 | 9 | 5.3 | CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
10311496 | 18077 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 515 | 6 | 2 | 3 | 5.5 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCNC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270370 | 18077 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 515 | 6 | 2 | 3 | 5.5 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCNC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
44380448 | 119774 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 670 | 12 | 1 | 6 | 6.4 | CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL352588 | 119774 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 670 | 12 | 1 | 6 | 6.4 | CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44315483 | 96151 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 728 | 13 | 2 | 7 | 5.0 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL263243 | 96151 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 728 | 13 | 2 | 7 | 5.0 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
101195489 | 155080 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 713 | 12 | 3 | 7 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
9875056 | 155080 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 713 | 12 | 3 | 7 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL404599 | 155080 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 713 | 12 | 3 | 7 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
9853636 | 203739 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 762 | 14 | 1 | 7 | 5.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL80355 | 203739 | 0 | None | -1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 762 | 14 | 1 | 7 | 5.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
10296442 | 75155 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 432 | 5 | 2 | 2 | 5.0 | C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL204306 | 75155 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 432 | 5 | 2 | 2 | 5.0 | C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
24768355 | 168329 | 0 | None | 15 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1077 | 22 | 9 | 9 | 4.7 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL438389 | 168329 | 0 | None | 15 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1077 | 22 | 9 | 9 | 4.7 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
10296442 | 75155 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 432 | 5 | 2 | 2 | 5.0 | C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL204306 | 75155 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 432 | 5 | 2 | 2 | 5.0 | C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
44560773 | 172400 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 524 | 7 | 2 | 4 | 4.1 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL451763 | 172400 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 524 | 7 | 2 | 4 | 4.1 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
10194796 | 191259 | 0 | None | 6309 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 5.6 | C[C@@H](OC[C@@]1(c2ccccc2)CCC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL519914 | 191259 | 0 | None | 6309 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 431 | 5 | 1 | 2 | 5.6 | C[C@@H](OC[C@@]1(c2ccccc2)CCC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL439019 | 212070 | 0 | None | 3 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
52940879 | 18144 | 0 | None | 489 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 563 | 6 | 2 | 3 | 4.8 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)NCCO)C[C@@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2010.08.138 | ||
CHEMBL1270786 | 18144 | 0 | None | 489 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 563 | 6 | 2 | 3 | 4.8 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)NCCO)C[C@@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2010.08.138 | ||
44307773 | 101890 | 0 | None | 17 | 2 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 779 | 13 | 0 | 7 | 7.6 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL303803 | 101890 | 0 | None | 17 | 2 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 779 | 13 | 0 | 7 | 7.6 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
44307757 | 201842 | 0 | None | 1 | 2 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 753 | 12 | 1 | 7 | 5.8 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL66441 | 201842 | 0 | None | 1 | 2 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 753 | 12 | 1 | 7 | 5.8 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
46889696 | 6852 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 615 | 6 | 2 | 5 | 6.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@H](O)C[C@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1084437 | 6852 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 615 | 6 | 2 | 5 | 6.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@H](O)C[C@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
24768355 | 168329 | 0 | None | 15 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1077 | 22 | 9 | 9 | 4.7 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm070332f | ||
CHEMBL438389 | 168329 | 0 | None | 15 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1077 | 22 | 9 | 9 | 4.7 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm070332f | ||
71458106 | 79189 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 4.0 | COc1ccccc1CN[C@H]1C2CCNC1(c1ccccc1)CC=C2C | 10.1016/0960-894X(95)00552-5 | ||
CHEMBL2114439 | 79189 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 4.0 | COc1ccccc1CN[C@H]1C2CCNC1(c1ccccc1)CC=C2C | 10.1016/0960-894X(95)00552-5 | ||
51003117 | 57567 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 545 | 4 | 0 | 2 | 7.2 | Cc1cc(F)ccc1[C@H]1C[C@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL1672049 | 57567 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 545 | 4 | 0 | 2 | 7.2 | Cc1cc(F)ccc1[C@H]1C[C@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
10311306 | 3315 | 47 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | nan | ||
5027 | 3315 | 47 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | nan | ||
5749 | 3315 | 47 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | nan | ||
CHEMBL3707331 | 3315 | 47 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | nan | ||
DB09291 | 3315 | 47 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | nan | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00104a018 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00104a018 | ||
10128131 | 18066 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 489 | 6 | 3 | 3 | 5.1 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270272 | 18066 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 489 | 6 | 3 | 3 | 5.1 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
44380337 | 57134 | 0 | None | 6 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 735 | 14 | 0 | 8 | 7.1 | CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL165465 | 57134 | 0 | None | 6 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 735 | 14 | 0 | 8 | 7.1 | CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380396 | 57415 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 698 | 12 | 3 | 7 | 6.4 | CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL166921 | 57415 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 698 | 12 | 3 | 7 | 6.4 | CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380082 | 57807 | 0 | None | 12 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 683 | 13 | 1 | 6 | 6.7 | CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL167606 | 57807 | 0 | None | 12 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 683 | 13 | 1 | 6 | 6.7 | CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380091 | 120209 | 0 | None | 2 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 684 | 13 | 1 | 6 | 6.8 | CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL354772 | 120209 | 0 | None | 2 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 684 | 13 | 1 | 6 | 6.8 | CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380473 | 120271 | 0 | None | 549 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 684 | 12 | 1 | 6 | 6.5 | CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL355429 | 120271 | 0 | None | 549 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 684 | 12 | 1 | 6 | 6.5 | CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
9896757 | 203273 | 0 | None | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 732 | 12 | 0 | 6 | 7.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL76580 | 203273 | 0 | None | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 732 | 12 | 0 | 6 | 7.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44241710 | 83118 | 0 | None | 3 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 613 | 6 | 2 | 5 | 6.1 | Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203703 | 83118 | 0 | None | 3 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 613 | 6 | 2 | 5 | 6.1 | Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
44314480 | 102466 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 705 | 13 | 3 | 5 | 7.1 | NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
CHEMBL306311 | 102466 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 705 | 13 | 3 | 5 | 7.1 | NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
10127439 | 172528 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 2 | 5.9 | C[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL452022 | 172528 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 2 | 5.9 | C[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.05.082 | ||
44241710 | 83118 | 0 | None | 3 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 613 | 6 | 2 | 5 | 6.1 | Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203703 | 83118 | 0 | None | 3 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 613 | 6 | 2 | 5 | 6.1 | Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
71452185 | 83122 | 0 | None | -2 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 690 | 7 | 1 | 6 | 5.6 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203707 | 83122 | 0 | None | -2 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 690 | 7 | 1 | 6 | 5.6 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
10817360 | 5122 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 598 | 9 | 2 | 3 | 6.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL106078 | 5122 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 598 | 9 | 2 | 3 | 6.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
10769059 | 108130 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 552 | 8 | 2 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 | 10.1021/jm970499g | ||
CHEMBL320581 | 108130 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 552 | 8 | 2 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 | 10.1021/jm970499g | ||
44307898 | 199788 | 0 | None | -1 | 2 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 767 | 12 | 0 | 7 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL60504 | 199788 | 0 | None | -1 | 2 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 767 | 12 | 0 | 7 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL387670 | 210664 | 0 | None | 109 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061369n | ||||
132837 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm900473p | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm900473p | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm900473p | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm800389v | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm800389v | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm800389v | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2009.08.035 | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2009.08.035 | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm070332f | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm101023r | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm070332f | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm101023r | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm070332f | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm101023r | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm100157m | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm100157m | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm100157m | ||
10128485 | 148055 | 7 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 515 | 5 | 3 | 4 | 4.7 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CN1)NC(=O)NC2=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
CHEMBL3939059 | 148055 | 7 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 515 | 5 | 3 | 4 | 4.7 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CN1)NC(=O)NC2=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | nan | ||
11296094 | 6353 | 0 | None | 3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 573 | 7 | 1 | 4 | 6.8 | CN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1082415 | 6353 | 0 | None | 3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 573 | 7 | 1 | 4 | 6.8 | CN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 | 10.1016/j.bmcl.2010.04.008 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00481-8 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00481-8 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00481-8 | ||
10621261 | 36300 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 404 | 6 | 2 | 5 | 4.3 | COc1ccc(-c2c(C)nn(C)c2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL144793 | 36300 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 404 | 6 | 2 | 5 | 4.3 | COc1ccc(-c2c(C)nn(C)c2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
9929728 | 39524 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 379 | 6 | 2 | 5 | 4.4 | COc1ccc(-c2nccs2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL147619 | 39524 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 379 | 6 | 2 | 5 | 4.4 | COc1ccc(-c2nccs2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
44408039 | 75151 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 569 | 8 | 2 | 5 | 4.9 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL204297 | 75151 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 569 | 8 | 2 | 5 | 4.9 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN | 10.1016/j.bmcl.2005.10.077 | ||
44408047 | 96320 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 597 | 9 | 1 | 5 | 5.5 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL264660 | 96320 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 597 | 9 | 1 | 5 | 5.5 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C | 10.1016/j.bmcl.2005.10.077 | ||
46224962 | 197723 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 518 | 2 | 2 | 3 | 5.2 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
CHEMBL591076 | 197723 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 518 | 2 | 2 | 3 | 5.2 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
10476340 | 94567 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 404 | 6 | 2 | 5 | 4.5 | COc1ccc(C2(C(F)(F)F)N=N2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00207-A | ||
CHEMBL25492 | 94567 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 404 | 6 | 2 | 5 | 4.5 | COc1ccc(C2(C(F)(F)F)N=N2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(95)00207-A | ||
44380206 | 57467 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 658 | 11 | 0 | 5 | 7.3 | CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL166961 | 57467 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 658 | 11 | 0 | 5 | 7.3 | CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380132 | 95980 | 0 | None | 4 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 730 | 14 | 0 | 6 | 7.2 | CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL262053 | 95980 | 0 | None | 4 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 730 | 14 | 0 | 6 | 7.2 | CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380290 | 99628 | 0 | None | 21 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 736 | 14 | 0 | 9 | 6.5 | CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL287369 | 99628 | 0 | None | 21 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 736 | 14 | 0 | 9 | 6.5 | CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
9961955 | 172204 | 0 | None | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 726 | 11 | 0 | 7 | 6.4 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL451235 | 172204 | 0 | None | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 726 | 11 | 0 | 7 | 6.4 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
9810544 | 203084 | 0 | None | -2 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 726 | 12 | 1 | 6 | 6.4 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL74956 | 203084 | 0 | None | -2 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 726 | 12 | 1 | 6 | 6.4 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44408107 | 74944 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 478 | 6 | 1 | 2 | 5.9 | CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)NC1=O | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL203740 | 74944 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 478 | 6 | 1 | 2 | 5.9 | CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)NC1=O | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL389651 | 210682 | 0 | None | 6 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
135413536 | 444 | 80 | None | 50 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
230 | 444 | 80 | None | 50 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
10817013 | 9166 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 577 | 9 | 3 | 4 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O | 10.1021/jm970499g | ||
CHEMBL110770 | 9166 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 577 | 9 | 3 | 4 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O | 10.1021/jm970499g | ||
44307821 | 101644 | 0 | None | 4 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 767 | 12 | 0 | 7 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL302329 | 101644 | 0 | None | 4 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 767 | 12 | 0 | 7 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
44307819 | 102123 | 0 | None | 1 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 725 | 12 | 0 | 6 | 6.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL304106 | 102123 | 0 | None | 1 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 725 | 12 | 0 | 6 | 6.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
44307677 | 168698 | 0 | None | -1 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 697 | 12 | 1 | 6 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL441252 | 168698 | 0 | None | -1 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 697 | 12 | 1 | 6 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
44307820 | 201940 | 0 | None | -1 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 725 | 12 | 0 | 6 | 6.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL67171 | 201940 | 0 | None | -1 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 725 | 12 | 0 | 6 | 6.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
11734825 | 13116 | 0 | None | 549 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 623 | 7 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1021/jm030786m | ||
CHEMBL119126 | 13116 | 0 | None | 549 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 623 | 7 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1021/jm030786m | ||
122187725 | 122551 | 0 | None | 2 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 691 | 11 | 6 | 5 | 4.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
CHEMBL3609621 | 122551 | 0 | None | 2 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 691 | 11 | 6 | 5 | 4.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
46889690 | 6873 | 0 | None | 9 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 585 | 5 | 1 | 4 | 7.0 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)C2)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1084522 | 6873 | 0 | None | 9 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 585 | 5 | 1 | 4 | 7.0 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)C2)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL2371977 | 208426 | 0 | None | 17 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
CHEMBL2419540 | 208696 | 0 | None | 4 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
10530375 | 5553 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 534 | 8 | 2 | 3 | 5.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL107763 | 5553 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 534 | 8 | 2 | 3 | 5.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 | 10.1021/jm970499g | ||
44380131 | 57308 | 0 | None | 3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 746 | 14 | 0 | 7 | 6.8 | CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL166828 | 57308 | 0 | None | 3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 746 | 14 | 0 | 7 | 6.8 | CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380415 | 119809 | 0 | None | 2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 683 | 12 | 1 | 6 | 5.9 | CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL352813 | 119809 | 0 | None | 2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 683 | 12 | 1 | 6 | 5.9 | CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
9831674 | 103932 | 0 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 712 | 12 | 1 | 6 | 5.9 | CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL310334 | 103932 | 0 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 712 | 12 | 1 | 6 | 5.9 | CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00462-6 | ||
9917970 | 203245 | 0 | None | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 683 | 11 | 0 | 5 | 7.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL76437 | 203245 | 0 | None | -1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 683 | 11 | 0 | 5 | 7.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44337201 | 108125 | 0 | None | 7 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 7 | 1 | 4 | 5.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL320548 | 108125 | 0 | None | 7 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 7 | 1 | 4 | 5.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
44299271 | 194374 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 510 | 10 | 2 | 3 | 5.5 | NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/s0960-894x(00)00463-7 | ||
CHEMBL56038 | 194374 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 510 | 10 | 2 | 3 | 5.5 | NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 | 10.1016/s0960-894x(00)00463-7 | ||
10231172 | 138735 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 519 | 6 | 2 | 3 | 5.1 | O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCNCC1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL379038 | 138735 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 519 | 6 | 2 | 3 | 5.1 | O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCNCC1 | 10.1016/j.bmcl.2005.10.072 | ||
44560755 | 172629 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 4.7 | CC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL452271 | 172629 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 488 | 6 | 2 | 3 | 4.7 | CC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.05.082 | ||
52946919 | 18143 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 476 | 4 | 1 | 2 | 5.4 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CNC[C@@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2010.08.138 | ||
CHEMBL1270785 | 18143 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 476 | 4 | 1 | 2 | 5.4 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CNC[C@@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2010.08.138 | ||
46889697 | 6853 | 0 | None | 32 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 643 | 8 | 0 | 5 | 7.6 | COC[C@@H]1C[C@@H](OC)CN1c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1084438 | 6853 | 0 | None | 32 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 643 | 8 | 0 | 5 | 7.6 | COC[C@@H]1C[C@@H](OC)CN1c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 | 10.1016/j.bmcl.2010.04.008 | ||
51003055 | 57564 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 533 | 4 | 0 | 2 | 7.1 | Cc1cc(F)ccc1[C@H]1C[C@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
CHEMBL1672046 | 57564 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 533 | 4 | 0 | 2 | 7.1 | Cc1cc(F)ccc1[C@H]1C[C@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1013264 | ||
4898 | 2724 | 78 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 10.1016/j.bmcl.2005.11.047 | ||
5742 | 2724 | 78 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 10.1016/j.bmcl.2005.11.047 | ||
6451149 | 2724 | 78 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL206253 | 2724 | 78 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 10.1016/j.bmcl.2005.11.047 | ||
DB09048 | 2724 | 78 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 10.1016/j.bmcl.2005.11.047 | ||
54581461 | 60934 | 0 | None | -6 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1143 | 29 | 10 | 12 | 4.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 | 10.1021/jm101023r | ||
CHEMBL1766207 | 60934 | 0 | None | -6 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1143 | 29 | 10 | 12 | 4.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 | 10.1021/jm101023r | ||
127032533 | 138258 | 0 | None | 10 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 1108 | 22 | 9 | 10 | 4.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN([C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)CC1 | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3780776 | 138258 | 0 | None | 10 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 1108 | 22 | 9 | 10 | 4.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN([C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)CC1 | 10.1021/acsmedchemlett.5b00359 | ||
71716116 | 85934 | 0 | None | 537 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 516 | 7 | 0 | 6 | 5.7 | C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)OCC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1021/jm301653f | ||
CHEMBL2313630 | 85934 | 0 | None | 537 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 516 | 7 | 0 | 6 | 5.7 | C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)OCC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1021/jm301653f | ||
44380062 | 120251 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 740 | 14 | 2 | 6 | 6.7 | CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL355295 | 120251 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 740 | 14 | 2 | 6 | 6.7 | CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
9961936 | 102615 | 0 | None | -1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 723 | 12 | 1 | 8 | 5.9 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL307498 | 102615 | 0 | None | -1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 723 | 12 | 1 | 8 | 5.9 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44315370 | 203131 | 0 | None | 1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 789 | 14 | 0 | 7 | 7.9 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL75479 | 203131 | 0 | None | 1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 789 | 14 | 0 | 7 | 7.9 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
9831075 | 203442 | 0 | None | -1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 657 | 10 | 1 | 6 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL78132 | 203442 | 0 | None | -1 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 657 | 10 | 1 | 6 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
5759 | 587 | 17 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 565 | 5 | 0 | 4 | 6.9 | O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C | 10.1016/j.bmcl.2005.11.047 | ||
6450815 | 587 | 17 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 565 | 5 | 0 | 4 | 6.9 | O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL204694 | 587 | 17 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 565 | 5 | 0 | 4 | 6.9 | O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C | 10.1016/j.bmcl.2005.11.047 | ||
44338517 | 6258 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 4.9 | COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL108200 | 6258 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 4.9 | COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
44358516 | 168010 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 446 | 6 | 1 | 3 | 5.2 | Cc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL435796 | 168010 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 446 | 6 | 1 | 3 | 5.2 | Cc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 | 10.1016/s0960-894x(02)00956-3 | ||
44346206 | 113162 | 3 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL332284 | 113162 | 3 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 417 | 5 | 1 | 2 | 5.9 | FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
145948847 | 166919 | 0 | None | -1 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 1123 | 22 | 9 | 9 | 5.5 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299423 | 166919 | 0 | None | -1 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 1123 | 22 | 9 | 9 | 5.5 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
10173890 | 77850 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 460 | 6 | 2 | 3 | 4.7 | C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL210591 | 77850 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 460 | 6 | 2 | 3 | 4.7 | C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
10151946 | 79955 | 0 | None | 1995 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.0 | CNC(=O)[C@]1(N)C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL214388 | 79955 | 0 | None | 1995 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 474 | 6 | 2 | 3 | 5.0 | CNC(=O)[C@]1(N)C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 | 10.1016/j.bmcl.2006.04.031 | ||
46889693 | 6874 | 0 | None | -1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 599 | 6 | 1 | 4 | 7.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1084523 | 6874 | 0 | None | -1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 599 | 6 | 1 | 4 | 7.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
44177670 | 60933 | 0 | None | -1 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 1151 | 27 | 10 | 10 | 5.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766206 | 60933 | 0 | None | -1 | 4 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 1151 | 27 | 10 | 10 | 5.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL426363 | 211597 | 0 | None | 26 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
11801327 | 9266 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 578 | 10 | 2 | 4 | 5.4 | COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL111295 | 9266 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 578 | 10 | 2 | 4 | 5.4 | COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
44307953 | 168628 | 0 | None | 35 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 784 | 12 | 1 | 7 | 6.4 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL440679 | 168628 | 0 | None | 35 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 784 | 12 | 1 | 7 | 6.4 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL540651 | 168628 | 0 | None | 35 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 784 | 12 | 1 | 7 | 6.4 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
9875181 | 170777 | 0 | None | 7 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 725 | 12 | 0 | 6 | 6.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL446146 | 170777 | 0 | None | 7 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 725 | 12 | 0 | 6 | 6.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
9810835 | 201881 | 0 | None | 7 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 767 | 12 | 0 | 7 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL66763 | 201881 | 0 | None | 7 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 767 | 12 | 0 | 7 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
9874206 | 202075 | 0 | None | 1 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 640 | 10 | 0 | 5 | 7.0 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL68060 | 202075 | 0 | None | 1 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 640 | 10 | 0 | 5 | 7.0 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
10762277 | 13370 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 379 | 6 | 3 | 8 | 1.8 | COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL1193282 | 13370 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 379 | 6 | 3 | 8 | 1.8 | COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL544660 | 13370 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 379 | 6 | 3 | 8 | 1.8 | COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/0960-894X(96)00163-1 | ||
44281977 | 108906 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 595 | 10 | 1 | 5 | 6.8 | CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL32197 | 108906 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 595 | 10 | 1 | 5 | 6.8 | CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
52949509 | 18078 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 524 | 7 | 2 | 4 | 5.0 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NS(C)(=O)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270371 | 18078 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 524 | 7 | 2 | 4 | 5.0 | C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NS(C)(=O)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.08.059 | ||
2098 | 3638 | 31 | None | -1 | 6 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00391a046 | ||||
36511 | 3638 | 31 | None | -1 | 6 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00391a046 | ||||
3805 | 3638 | 31 | None | -1 | 6 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00391a046 | ||||
3835 | 3638 | 31 | None | -1 | 6 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00391a046 | ||||
CHEMBL235363 | 3638 | 31 | None | -1 | 6 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00391a046 | ||||
44315298 | 102637 | 0 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 721 | 12 | 0 | 6 | 7.9 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL307733 | 102637 | 0 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 721 | 12 | 0 | 6 | 7.9 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL2372071 | 208433 | 11 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O | 10.1016/s0960-894x(98)00219-4 | ||||
9808347 | 140231 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 579 | 5 | 0 | 5 | 6.2 | Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL381832 | 140231 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 579 | 5 | 0 | 5 | 6.2 | Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
127030411 | 138263 | 0 | None | 48 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1053 | 22 | 9 | 9 | 5.2 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N(C)[C@@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@@H]1c1ccccc1 | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3780820 | 138263 | 0 | None | 48 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1053 | 22 | 9 | 9 | 5.2 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N(C)[C@@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@@H]1c1ccccc1 | 10.1021/acsmedchemlett.5b00359 | ||
52946726 | 17975 | 0 | None | 173 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 607 | 8 | 2 | 4 | 4.5 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N(CCO)CCO)C[C@@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2010.08.138 | ||
CHEMBL1269638 | 17975 | 0 | None | 173 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 607 | 8 | 2 | 4 | 4.5 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N(CCO)CCO)C[C@@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2010.08.138 | ||
CHEMBL2419537 | 208693 | 0 | None | -32 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
44241710 | 83118 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 613 | 6 | 2 | 5 | 6.1 | Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203703 | 83118 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 613 | 6 | 2 | 5 | 6.1 | Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00104a018 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00104a018 | ||
10650495 | 106935 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 559 | 8 | 2 | 4 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N | 10.1021/jm970499g | ||
CHEMBL318085 | 106935 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 559 | 8 | 2 | 4 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N | 10.1021/jm970499g | ||
10626666 | 108708 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 559 | 8 | 2 | 4 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 | 10.1021/jm970499g | ||
CHEMBL321554 | 108708 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 559 | 8 | 2 | 4 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 | 10.1021/jm970499g | ||
44307741 | 202090 | 0 | None | 15 | 2 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 753 | 12 | 1 | 7 | 5.8 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL68234 | 202090 | 0 | None | 15 | 2 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 753 | 12 | 1 | 7 | 5.8 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
10303099 | 7196 | 0 | None | 9 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 559 | 7 | 2 | 4 | 6.8 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(NCCO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1086003 | 7196 | 0 | None | 9 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 559 | 7 | 2 | 4 | 6.8 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(NCCO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
52940877 | 18138 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 502 | 7 | 2 | 3 | 5.8 | CCNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
CHEMBL1270767 | 18138 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 502 | 7 | 2 | 3 | 5.8 | CCNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 | 10.1016/j.bmcl.2010.08.059 | ||
44216236 | 6429 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 603 | 9 | 2 | 5 | 6.2 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1082737 | 6429 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 603 | 9 | 2 | 5 | 6.2 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
44380279 | 57514 | 0 | None | 3 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 761 | 15 | 1 | 7 | 6.3 | CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL166975 | 57514 | 0 | None | 3 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 761 | 15 | 1 | 7 | 6.3 | CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380414 | 57847 | 0 | None | 3 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 699 | 12 | 2 | 7 | 5.9 | CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL167994 | 57847 | 0 | None | 3 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 699 | 12 | 2 | 7 | 5.9 | CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44315421 | 105248 | 0 | None | 2 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 765 | 14 | 1 | 8 | 7.4 | CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL312612 | 105248 | 0 | None | 2 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 765 | 14 | 1 | 8 | 7.4 | CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
15508105 | 203123 | 0 | None | -1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 675 | 10 | 1 | 7 | 7.9 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL75422 | 203123 | 0 | None | -1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 675 | 10 | 1 | 7 | 7.9 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
127033167 | 138224 | 0 | None | 33 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1067 | 23 | 9 | 9 | 5.3 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3780408 | 138224 | 0 | None | 33 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1067 | 23 | 9 | 9 | 5.3 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1021/acsmedchemlett.5b00359 | ||
9874206 | 202075 | 0 | None | 1 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 640 | 10 | 0 | 5 | 7.0 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL68060 | 202075 | 0 | None | 1 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 640 | 10 | 0 | 5 | 7.0 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
9874473 | 41564 | 0 | None | 16 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 659 | 10 | 0 | 4 | 8.4 | CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm030197g | ||
CHEMBL149326 | 41564 | 0 | None | 16 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 659 | 10 | 0 | 4 | 8.4 | CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm030197g | ||
44407998 | 75147 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL204262 | 75147 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 639 | 10 | 1 | 6 | 5.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
44408046 | 140213 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 667 | 11 | 1 | 6 | 6.1 | C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL381814 | 140213 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 667 | 11 | 1 | 6 | 6.1 | C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
44407971 | 140223 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 625 | 9 | 1 | 6 | 4.9 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL381822 | 140223 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 625 | 9 | 1 | 6 | 4.9 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
44358335 | 26657 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.2 | C[C@H](OC[C@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL136347 | 26657 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.2 | C[C@H](OC[C@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
10437488 | 29712 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 548 | 11 | 1 | 5 | 5.3 | C[C@H](OC[C@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL138824 | 29712 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 548 | 11 | 1 | 5 | 5.3 | C[C@H](OC[C@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
20599018 | 197722 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 517 | 2 | 1 | 2 | 6.5 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
CHEMBL591075 | 197722 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 517 | 2 | 1 | 2 | 6.5 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
9826304 | 186432 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 477 | 3 | 1 | 2 | 5.4 | Cc1cc(F)ccc1C1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
CHEMBL490755 | 186432 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 477 | 3 | 1 | 2 | 5.4 | Cc1cc(F)ccc1C1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
2106 | 3490 | 3 | None | -5 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C | 10.1016/s0960-894x(02)00462-6 | ||
9875034 | 3490 | 3 | None | -5 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL77023 | 3490 | 3 | None | -5 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C | 10.1016/s0960-894x(02)00462-6 | ||
44315390 | 203333 | 0 | None | 1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 733 | 12 | 1 | 8 | 7.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL77042 | 203333 | 0 | None | 1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 733 | 12 | 1 | 8 | 7.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44315576 | 203534 | 0 | None | 1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 747 | 12 | 0 | 9 | 7.2 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL78851 | 203534 | 0 | None | 1 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 747 | 12 | 0 | 9 | 7.2 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
10304406 | 139810 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 613 | 5 | 0 | 5 | 6.3 | Cc1ccccc1-c1cc(N2CCS(=O)(=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL380705 | 139810 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 613 | 5 | 0 | 5 | 6.3 | Cc1ccccc1-c1cc(N2CCS(=O)(=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
155551678 | 174859 | 0 | None | -4 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 697 | 12 | 1 | 6 | 6.9 | CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1021/acs.jmedchem.9b00017 | ||
CHEMBL4576324 | 174859 | 0 | None | -4 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 697 | 12 | 1 | 6 | 6.9 | CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1021/acs.jmedchem.9b00017 | ||
10218122 | 137855 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 528 | 6 | 1 | 3 | 6.2 | C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL377242 | 137855 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 528 | 6 | 1 | 3 | 6.2 | C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
10239346 | 138214 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 514 | 6 | 1 | 3 | 5.9 | C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL378027 | 138214 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 514 | 6 | 1 | 3 | 5.9 | C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
71452185 | 83122 | 0 | None | -2 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 690 | 7 | 1 | 6 | 5.6 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203707 | 83122 | 0 | None | -2 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 690 | 7 | 1 | 6 | 5.6 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
71453994 | 83121 | 0 | None | 10 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 583 | 5 | 1 | 4 | 6.7 | Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203706 | 83121 | 0 | None | 10 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 583 | 5 | 1 | 4 | 6.7 | Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
44307679 | 201823 | 0 | None | -1 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL66332 | 201823 | 0 | None | -1 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00340-2 | ||
46889667 | 6795 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 617 | 10 | 2 | 5 | 6.6 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCCO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1084165 | 6795 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 617 | 10 | 2 | 5 | 6.6 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCCO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
9872249 | 76197 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 549 | 5 | 0 | 3 | 6.7 | Cc1ccccc1-c1cc(N2CCN(C)CC2)ccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL206171 | 76197 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 549 | 5 | 0 | 3 | 6.7 | Cc1ccccc1-c1cc(N2CCN(C)CC2)ccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
127031644 | 138305 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1007 | 16 | 7 | 8 | 5.3 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3781336 | 138305 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1007 | 16 | 7 | 8 | 5.3 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
127033173 | 138315 | 0 | None | -2 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1062 | 16 | 7 | 9 | 5.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3781519 | 138315 | 0 | None | -2 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1062 | 16 | 7 | 9 | 5.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
145948797 | 166915 | 0 | None | -1 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1105 | 22 | 9 | 9 | 5.3 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299390 | 166915 | 0 | None | -1 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1105 | 22 | 9 | 9 | 5.3 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
24768356 | 155321 | 0 | None | 4 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1091 | 22 | 8 | 9 | 5.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm070332f | ||
CHEMBL406030 | 155321 | 0 | None | 4 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1091 | 22 | 8 | 9 | 5.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm070332f | ||
52943089 | 17976 | 0 | None | 263 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 630 | 4 | 0 | 3 | 5.4 | CC(=O)N1CCN(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2010.08.138 | ||
CHEMBL1269639 | 17976 | 0 | None | 263 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 630 | 4 | 0 | 3 | 5.4 | CC(=O)N1CCN(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2010.08.138 | ||
11490769 | 83123 | 0 | None | 6 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 660 | 6 | 0 | 5 | 6.3 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203708 | 83123 | 0 | None | 6 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 660 | 6 | 0 | 5 | 6.3 | Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
71457524 | 83120 | 0 | None | -5 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 597 | 6 | 1 | 4 | 7.1 | Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203705 | 83120 | 0 | None | -5 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 597 | 6 | 1 | 4 | 7.1 | Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
71455736 | 83124 | 0 | None | 6 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 687 | 5 | 0 | 6 | 6.9 | Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203709 | 83124 | 0 | None | 6 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 687 | 5 | 0 | 6 | 6.9 | Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
44380526 | 58020 | 0 | None | -1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 665 | 11 | 0 | 6 | 6.9 | CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL168272 | 58020 | 0 | None | -1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 665 | 11 | 0 | 6 | 6.9 | CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44315369 | 102545 | 0 | None | 1 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 689 | 10 | 0 | 7 | 7.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL306952 | 102545 | 0 | None | 1 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 689 | 10 | 0 | 7 | 7.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44305818 | 14626 | 0 | None | 1 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 698 | 13 | 3 | 8 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 | 10.1016/S0960-894X(96)00604-X | ||
CHEMBL1206764 | 14626 | 0 | None | 1 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 698 | 13 | 3 | 8 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 | 10.1016/S0960-894X(96)00604-X | ||
CHEMBL305119 | 14626 | 0 | None | 1 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 698 | 13 | 3 | 8 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 | 10.1016/S0960-894X(96)00604-X | ||
85169 | 6837 | 6 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/ml5002954 | ||
CHEMBL108438 | 6837 | 6 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/ml5002954 | ||
85169 | 6837 | 6 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/ml5002954 | ||
CHEMBL108438 | 6837 | 6 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/ml5002954 | ||
10204249 | 75213 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 450 | 5 | 2 | 2 | 5.1 | C[C@@H](OC[C@@]1(c2ccc(F)cc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL204554 | 75213 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 450 | 5 | 2 | 2 | 5.1 | C[C@@H](OC[C@@]1(c2ccc(F)cc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
85169 | 6837 | 6 | None | -2 | 2 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm901352b | ||
CHEMBL108438 | 6837 | 6 | None | -2 | 2 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm901352b | ||
85169 | 6837 | 6 | None | -2 | 2 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1016/j.bmcl.2018.06.009 | ||
CHEMBL108438 | 6837 | 6 | None | -2 | 2 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1016/j.bmcl.2018.06.009 | ||
44233410 | 193921 | 0 | None | 38 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1327 | 28 | 14 | 16 | 1.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL555504 | 193921 | 0 | None | 38 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1327 | 28 | 14 | 16 | 1.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)80386-3 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)80386-3 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)80386-3 | ||
44307678 | 196998 | 0 | None | 1 | 2 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL57993 | 196998 | 0 | None | 1 | 2 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00340-2 | ||
46889694 | 6498 | 0 | None | 4 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 599 | 6 | 1 | 4 | 7.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1083052 | 6498 | 0 | None | 4 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 599 | 6 | 1 | 4 | 7.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
46889698 | 6854 | 0 | None | -1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 615 | 6 | 2 | 5 | 6.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)[C@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1084439 | 6854 | 0 | None | -1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 615 | 6 | 2 | 5 | 6.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)[C@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
44407902 | 75073 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 652 | 9 | 1 | 6 | 5.2 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL204114 | 75073 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 652 | 9 | 1 | 6 | 5.2 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 | 10.1016/j.bmcl.2005.10.077 | ||
44338518 | 7641 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 466 | 6 | 1 | 3 | 5.5 | FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL108889 | 7641 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 466 | 6 | 1 | 3 | 5.5 | FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
22353151 | 9043 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 432 | 6 | 1 | 3 | 4.9 | FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL109937 | 9043 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 432 | 6 | 1 | 3 | 4.9 | FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
44358612 | 30986 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 446 | 6 | 0 | 3 | 5.2 | CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL140080 | 30986 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 446 | 6 | 0 | 3 | 5.2 | CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
44358249 | 116050 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 484 | 8 | 1 | 3 | 6.2 | C=Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1C=C | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL336305 | 116050 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 484 | 8 | 1 | 3 | 6.2 | C=Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1C=C | 10.1016/s0960-894x(02)00956-3 | ||
44338359 | 162877 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 466 | 6 | 1 | 3 | 5.5 | FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL419742 | 162877 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 466 | 6 | 1 | 3 | 5.5 | FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
44380338 | 119970 | 0 | None | 4 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 734 | 14 | 0 | 7 | 7.7 | CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL354196 | 119970 | 0 | None | 4 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 734 | 14 | 0 | 7 | 7.7 | CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44315297 | 203159 | 0 | None | -1 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 833 | 15 | 1 | 8 | 8.0 | CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL75698 | 203159 | 0 | None | -1 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 833 | 15 | 1 | 8 | 8.0 | CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL589979 | 214024 | 10 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm400209h | ||||
2098 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00219-4 | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00219-4 | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00219-4 | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00219-4 | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00219-4 | ||||
22960739 | 75258 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 533 | 8 | 1 | 3 | 5.4 | O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1CCN1CCCC1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL204714 | 75258 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 533 | 8 | 1 | 3 | 5.4 | O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1CCN1CCCC1 | 10.1016/j.bmcl.2005.10.072 | ||
44177770 | 122486 | 0 | None | -31 | 4 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 939 | 20 | 8 | 9 | 4.1 | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
CHEMBL3608937 | 122486 | 0 | None | -31 | 4 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 939 | 20 | 8 | 9 | 4.1 | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
CHEMBL589979 | 214024 | 10 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm901352b | ||||
CHEMBL589979 | 214024 | 10 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2018.06.009 | ||||
24768354 | 97517 | 0 | None | 28 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 955 | 22 | 8 | 9 | 3.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 | 10.1021/jm070332f | ||
CHEMBL272665 | 97517 | 0 | None | 28 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 955 | 22 | 8 | 9 | 3.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 | 10.1021/jm070332f | ||
CHEMBL2419543 | 208699 | 0 | None | -16 | 4 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
CHEMBL261390 | 208773 | 0 | None | -34 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm070332f | ||||
71461646 | 78499 | 0 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 676 | 11 | 0 | 5 | 7.6 | CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL2112941 | 78499 | 0 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 676 | 11 | 0 | 5 | 7.6 | CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380289 | 119749 | 0 | None | 14 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 734 | 14 | 0 | 7 | 7.7 | CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL352364 | 119749 | 0 | None | 14 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 734 | 14 | 0 | 7 | 7.7 | CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44407939 | 75008 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 460 | 6 | 1 | 2 | 5.7 | CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL203753 | 75008 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 460 | 6 | 1 | 2 | 5.7 | CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2005.10.072 | ||
9850565 | 75841 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 551 | 5 | 0 | 5 | 5.5 | Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL205829 | 75841 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 551 | 5 | 0 | 5 | 5.5 | Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
44408838 | 140735 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | Cc1ccccc1-c1cnc(N2CCN(C)CC2)cc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL383125 | 140735 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | Cc1ccccc1-c1cnc(N2CCN(C)CC2)cc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
71455736 | 83124 | 0 | None | 6 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 687 | 5 | 0 | 6 | 6.9 | Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203709 | 83124 | 0 | None | 6 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 687 | 5 | 0 | 6 | 6.9 | Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
10745532 | 9141 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 564 | 9 | 3 | 4 | 4.7 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1CO | 10.1021/jm970499g | ||
CHEMBL110656 | 9141 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 564 | 9 | 3 | 4 | 4.7 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1CO | 10.1021/jm970499g | ||
10555763 | 107556 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 3 | 6.5 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL319476 | 107556 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 3 | 6.5 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
9874473 | 41564 | 0 | None | 16 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 659 | 10 | 0 | 4 | 8.4 | CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm030197g | ||
CHEMBL149326 | 41564 | 0 | None | 16 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 659 | 10 | 0 | 4 | 8.4 | CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm030197g | ||
46889668 | 6497 | 0 | None | 8 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 599 | 5 | 1 | 4 | 7.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC(O)C2)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1083051 | 6497 | 0 | None | 8 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 599 | 5 | 1 | 4 | 7.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC(O)C2)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
44380080 | 12136 | 0 | None | 323 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 726 | 14 | 0 | 5 | 7.5 | CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL1184507 | 12136 | 0 | None | 323 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 726 | 14 | 0 | 5 | 7.5 | CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL352842 | 12136 | 0 | None | 323 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 726 | 14 | 0 | 5 | 7.5 | CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
10145229 | 9083 | 0 | None | 2 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 592 | 7 | 1 | 4 | 5.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL110219 | 9083 | 0 | None | 2 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 592 | 7 | 1 | 4 | 5.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
44337370 | 106932 | 0 | None | 147 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 700 | 7 | 1 | 4 | 7.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL318081 | 106932 | 0 | None | 147 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 700 | 7 | 1 | 4 | 7.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
101658885 | 160941 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 899 | 27 | 12 | 12 | -3.5 | N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2018.06.009 | ||
CHEMBL4127872 | 160941 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 899 | 27 | 12 | 12 | -3.5 | N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2018.06.009 | ||
44233184 | 193100 | 0 | None | 12 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1343 | 32 | 15 | 16 | 1.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL538131 | 193100 | 0 | None | 12 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1343 | 32 | 15 | 16 | 1.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
44380092 | 119855 | 0 | None | 12 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 698 | 12 | 1 | 6 | 7.2 | CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL353162 | 119855 | 0 | None | 12 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 698 | 12 | 1 | 6 | 7.2 | CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44315589 | 203130 | 0 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 804 | 16 | 1 | 9 | 7.2 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL75478 | 203130 | 0 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 804 | 16 | 1 | 9 | 7.2 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
9831707 | 203318 | 0 | None | -3 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 718 | 11 | 0 | 6 | 7.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL76965 | 203318 | 0 | None | -3 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 718 | 11 | 0 | 6 | 7.7 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
127033168 | 138245 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1021 | 17 | 7 | 8 | 5.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3780686 | 138245 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1021 | 17 | 7 | 8 | 5.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
44315589 | 203130 | 0 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 804 | 16 | 1 | 9 | 7.2 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1021/acs.jmedchem.9b00017 | ||
CHEMBL75478 | 203130 | 0 | None | 2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 804 | 16 | 1 | 9 | 7.2 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1021/acs.jmedchem.9b00017 | ||
49863734 | 15160 | 0 | None | 13 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1477 | 21 | 11 | 14 | 6.8 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm100157m | ||
CHEMBL1214027 | 15160 | 0 | None | 13 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1477 | 21 | 11 | 14 | 6.8 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm100157m | ||
11793946 | 37994 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 376 | 6 | 2 | 5 | 3.7 | COc1ccc(-c2nccn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL146210 | 37994 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 376 | 6 | 2 | 5 | 3.7 | COc1ccc(-c2nccn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
44408045 | 75254 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.2 | CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL204691 | 75254 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.2 | CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2005.10.077 | ||
44358318 | 30032 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 5.0 | Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL139088 | 30032 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 5.0 | Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
22353158 | 30667 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 476 | 8 | 1 | 4 | 4.6 | OCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL139750 | 30667 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 476 | 8 | 1 | 4 | 4.6 | OCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
44358456 | 118388 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 523 | 8 | 0 | 4 | 6.2 | FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3ccccn3)CC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL342266 | 118388 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 523 | 8 | 0 | 4 | 6.2 | FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3ccccn3)CC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
10741553 | 13385 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 435 | 9 | 2 | 8 | 3.1 | CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL1193479 | 13385 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 435 | 9 | 2 | 8 | 3.1 | CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 | 10.1016/0960-894X(96)00163-1 | ||
CHEMBL544892 | 13385 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 435 | 9 | 2 | 8 | 3.1 | CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 | 10.1016/0960-894X(96)00163-1 | ||
9892922 | 100436 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 521 | 3 | 1 | 2 | 6.3 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 | 10.1021/jm1016285 | ||
CHEMBL293844 | 100436 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 521 | 3 | 1 | 2 | 6.3 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 | 10.1021/jm1016285 | ||
44215305 | 118749 | 0 | None | 1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 695 | 12 | 0 | 5 | 8.4 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL343627 | 118749 | 0 | None | 1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 695 | 12 | 0 | 5 | 8.4 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44407907 | 75345 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 715 | 11 | 1 | 6 | 6.7 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL204764 | 75345 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 715 | 11 | 1 | 6 | 6.7 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
44407917 | 96110 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 617 | 8 | 1 | 5 | 6.6 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL262989 | 96110 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 617 | 8 | 1 | 5 | 6.6 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 | 10.1016/j.bmcl.2005.10.077 | ||
44408088 | 139295 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 639 | 9 | 1 | 6 | 5.3 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL379898 | 139295 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 639 | 9 | 1 | 6 | 5.3 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
44358568 | 30480 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 489 | 8 | 1 | 4 | 4.1 | NC(=O)CN1CCN([C@@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL139499 | 30480 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 489 | 8 | 1 | 4 | 4.1 | NC(=O)CN1CCN([C@@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
10302076 | 30517 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 532 | 11 | 1 | 4 | 5.9 | O=C(O)CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL139531 | 30517 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 532 | 11 | 1 | 4 | 5.9 | O=C(O)CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
9892922 | 100436 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 521 | 3 | 1 | 2 | 6.3 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 | 10.1016/S0960-894X(97)00353-3 | ||
CHEMBL293844 | 100436 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 521 | 3 | 1 | 2 | 6.3 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 | 10.1016/S0960-894X(97)00353-3 | ||
44281685 | 99569 | 0 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 587 | 10 | 1 | 6 | 6.6 | CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL286901 | 99569 | 0 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 587 | 10 | 1 | 6 | 6.6 | CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44281538 | 109824 | 0 | None | 1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 696 | 11 | 1 | 5 | 8.2 | CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL32385 | 109824 | 0 | None | 1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 696 | 11 | 1 | 5 | 8.2 | CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
3082491 | 197637 | 15 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 277 | 7 | 3 | 3 | 0.6 | CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm901352b | ||
CHEMBL590518 | 197637 | 15 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 277 | 7 | 3 | 3 | 0.6 | CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm901352b | ||
CHEMBL58178 | 214002 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm901352b | ||||
CHEMBL591489 | 214025 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | None | None | None | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1 | 10.1021/jm901352b | ||||
44380277 | 58933 | 0 | None | 2 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 702 | 13 | 1 | 5 | 9.3 | C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL170325 | 58933 | 0 | None | 2 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 702 | 13 | 1 | 5 | 9.3 | C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
73212439 | 104128 | 0 | None | 10 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 545 | 8 | 2 | 4 | 4.3 | CC(C)(C(=O)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL3104782 | 104128 | 0 | None | 10 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 545 | 8 | 2 | 4 | 4.3 | CC(C)(C(=O)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
44338531 | 9268 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 408 | 6 | 1 | 3 | 5.4 | CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL111304 | 9268 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 408 | 6 | 1 | 3 | 5.4 | CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 | 10.1016/s0960-894x(02)00956-3 | ||
44358346 | 26581 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 364 | 6 | 1 | 3 | 4.2 | Clc1ccc(COCC(c2ccccc2)N2CCNCC2)cc1Cl | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL136279 | 26581 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 364 | 6 | 1 | 3 | 4.2 | Clc1ccc(COCC(c2ccccc2)N2CCNCC2)cc1Cl | 10.1016/s0960-894x(02)00956-3 | ||
46224962 | 197723 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 518 | 2 | 2 | 3 | 5.2 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
CHEMBL591076 | 197723 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 518 | 2 | 2 | 3 | 5.2 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
CHEMBL261608 | 208774 | 0 | None | -3 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 | 10.1021/jm070332f | ||||
44281332 | 112411 | 0 | None | -100 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 588 | 11 | 1 | 8 | 6.4 | CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL33106 | 112411 | 0 | None | -100 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 588 | 11 | 1 | 8 | 6.4 | CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44304397 | 201595 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 473 | 2 | 0 | 2 | 5.3 | CC1c2ccccc2N(C)C(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)00353-3 | ||
CHEMBL64698 | 201595 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 473 | 2 | 0 | 2 | 5.3 | CC1c2ccccc2N(C)C(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)00353-3 | ||
44304302 | 201631 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 385 | 3 | 1 | 2 | 4.3 | CN(Cc1ccccc1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 | 10.1016/S0960-894X(97)00353-3 | ||
CHEMBL64862 | 201631 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 385 | 3 | 1 | 2 | 4.3 | CN(Cc1ccccc1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 | 10.1016/S0960-894X(97)00353-3 | ||
45379600 | 197498 | 0 | None | - | 1 | Rat | 5.0 | pKi | = | 5 | Binding | ChEMBL | 355 | 8 | 3 | 4 | 1.1 | COc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2C)C(N)=O)cc1 | 10.1021/jm901352b | ||
CHEMBL589543 | 197498 | 0 | None | - | 1 | Rat | 5.0 | pKi | = | 5 | Binding | ChEMBL | 355 | 8 | 3 | 4 | 1.1 | COc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2C)C(N)=O)cc1 | 10.1021/jm901352b | ||
57391133 | 68025 | 0 | None | 1 | 2 | Human | 4.0 | pKi | = | 4 | Binding | ChEMBL | 691 | 12 | 3 | 7 | 4.4 | COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 | 10.1016/j.ejmech.2011.08.042 | ||
CHEMBL1916635 | 68025 | 0 | None | 1 | 2 | Human | 4.0 | pKi | = | 4 | Binding | ChEMBL | 691 | 12 | 3 | 7 | 4.4 | COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 | 10.1016/j.ejmech.2011.08.042 | ||
11799987 | 5246 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 514 | 9 | 2 | 3 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL106754 | 5246 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 514 | 9 | 2 | 3 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1 | 10.1021/jm970499g | ||
118731115 | 117668 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 726 | 16 | 7 | 7 | 2.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2ccccc2)CC(C)C)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408732 | 117668 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 726 | 16 | 7 | 7 | 2.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2ccccc2)CC(C)C)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
44380107 | 119595 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 733 | 14 | 1 | 6 | 8.6 | CN(C)CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL350952 | 119595 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 733 | 14 | 1 | 6 | 8.6 | CN(C)CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
86274487 | 159542 | 0 | None | -933 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 408 | 2 | 0 | 7 | 3.6 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 | nan | ||
CHEMBL4108583 | 159542 | 0 | None | -933 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 408 | 2 | 0 | 7 | 3.6 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 | nan | ||
44318455 | 104198 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 510 | 4 | 1 | 4 | 4.7 | N#Cc1cccc(CN2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL310521 | 104198 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 510 | 4 | 1 | 4 | 4.7 | N#Cc1cccc(CN2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 | 10.1016/s0960-894x(02)00488-2 | ||
44334501 | 4940 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 567 | 2 | 0 | 4 | 4.4 | CC(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL105055 | 4940 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 567 | 2 | 0 | 4 | 4.4 | CC(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00659-5 | ||
44337207 | 7748 | 0 | None | -10 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 649 | 8 | 2 | 5 | 4.8 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL108955 | 7748 | 0 | None | -10 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 649 | 8 | 2 | 5 | 4.8 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
44177669 | 60932 | 0 | None | -52 | 4 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1233 | 27 | 9 | 10 | 6.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766205 | 60932 | 0 | None | -52 | 4 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1233 | 27 | 9 | 10 | 6.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
46889691 | 6849 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 613 | 6 | 1 | 4 | 7.7 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1084434 | 6849 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 613 | 6 | 1 | 4 | 7.7 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL589082 | 214021 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | None | None | None | C[C@@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm901352b | ||||
44611293 | 90642 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 325 | 7 | 3 | 3 | 1.1 | Cc1ccccc1C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
CHEMBL2397493 | 90642 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 325 | 7 | 3 | 3 | 1.1 | Cc1ccccc1C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
44337078 | 106711 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 859 | 11 | 0 | 5 | 10.5 | O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL316552 | 106711 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 859 | 11 | 0 | 5 | 10.5 | O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL2372070 | 208432 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | None | None | None | CN(C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(98)00219-4 | ||||
19610193 | 106748 | 0 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 5.3 | COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL316740 | 106748 | 0 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 5.3 | COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC | 10.1016/s0960-894x(02)00645-5 | ||
44364001 | 39664 | 0 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 717 | 13 | 1 | 5 | 8.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL147767 | 39664 | 0 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 717 | 13 | 1 | 5 | 8.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44314865 | 203403 | 0 | None | 3 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 738 | 13 | 0 | 6 | 8.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL77752 | 203403 | 0 | None | 3 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 738 | 13 | 0 | 6 | 8.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44281505 | 116390 | 0 | None | -2 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 576 | 11 | 1 | 5 | 6.9 | CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL33833 | 116390 | 0 | None | -2 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 576 | 11 | 1 | 5 | 6.9 | CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44281334 | 118889 | 0 | None | -2 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 541 | 11 | 1 | 6 | 6.1 | CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL34460 | 118889 | 0 | None | -2 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 541 | 11 | 1 | 6 | 6.1 | CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44363909 | 35671 | 0 | None | -5 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 739 | 13 | 0 | 7 | 8.5 | CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL144223 | 35671 | 0 | None | -5 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 739 | 13 | 0 | 7 | 8.5 | CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/s0960-894x(00)00702-2 | ||
44281587 | 53276 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 660 | 11 | 1 | 6 | 7.4 | CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL160210 | 53276 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 660 | 11 | 1 | 6 | 7.4 | CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
76317390 | 104130 | 0 | None | 5 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 633 | 6 | 1 | 4 | 7.4 | Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL3104784 | 104130 | 0 | None | 5 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 633 | 6 | 1 | 4 | 7.4 | Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
44408089 | 139656 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 653 | 10 | 1 | 6 | 5.7 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL380449 | 139656 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 653 | 10 | 1 | 6 | 5.7 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
44408051 | 140696 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 635 | 7 | 1 | 6 | 5.6 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL382871 | 140696 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 635 | 7 | 1 | 6 | 5.6 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
44338546 | 108121 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 382 | 6 | 1 | 3 | 4.0 | Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL320535 | 108121 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 382 | 6 | 1 | 3 | 4.0 | Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
71717930 | 85935 | 0 | None | -39 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 448 | 7 | 0 | 6 | 4.3 | CCOC(=O)N(c1ccccc1)C1CCN(CCn2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm301653f | ||
CHEMBL2313631 | 85935 | 0 | None | -39 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 448 | 7 | 0 | 6 | 4.3 | CCOC(=O)N(c1ccccc1)C1CCN(CCn2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm301653f | ||
73350089 | 88978 | 0 | None | 19 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 816 | 9 | 8 | 9 | 0.5 | CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC | 10.1021/jm00029a007 | ||
CHEMBL2370510 | 88978 | 0 | None | 19 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 816 | 9 | 8 | 9 | 0.5 | CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC | 10.1021/jm00029a007 | ||
73354570 | 88980 | 0 | None | 13 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 814 | 8 | 8 | 9 | 0.4 | COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C | 10.1021/jm00029a007 | ||
CHEMBL2370513 | 88980 | 0 | None | 13 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 814 | 8 | 8 | 9 | 0.4 | COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C | 10.1021/jm00029a007 | ||
44314866 | 102432 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 718 | 13 | 1 | 6 | 8.0 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)Nc2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL306039 | 102432 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 718 | 13 | 1 | 6 | 8.0 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)Nc2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44314454 | 105138 | 0 | None | 4 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 758 | 12 | 0 | 6 | 7.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL312295 | 105138 | 0 | None | 4 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 758 | 12 | 0 | 6 | 7.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
90644614 | 112212 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288158 | 112212 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3304470 | 112212 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
90644604 | 112247 | 0 | None | 12 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 683 | 11 | 2 | 6 | 5.3 | CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288153 | 112247 | 0 | None | 12 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 683 | 11 | 2 | 6 | 5.3 | CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3305011 | 112247 | 0 | None | 12 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 683 | 11 | 2 | 6 | 5.3 | CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
44358589 | 28806 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 386 | 9 | 1 | 6 | 2.9 | COc1cc(COCC(c2ccccc2)N2CCNCC2)cc(OC)c1OC | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL138056 | 28806 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 386 | 9 | 1 | 6 | 2.9 | COc1cc(COCC(c2ccccc2)N2CCNCC2)cc(OC)c1OC | 10.1016/s0960-894x(02)00956-3 | ||
9853827 | 84797 | 0 | None | -794 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 790 | 10 | 6 | 8 | 1.5 | O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 | 10.1021/jm040832y | ||
CHEMBL225588 | 84797 | 0 | None | -794 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 790 | 10 | 6 | 8 | 1.5 | O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 | 10.1021/jm040832y | ||
9872676 | 77826 | 0 | None | -3162 | 17 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 565 | 11 | 2 | 10 | 4.8 | COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 | 10.1021/jm060012g | ||
CHEMBL210514 | 77826 | 0 | None | -3162 | 17 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 565 | 11 | 2 | 10 | 4.8 | COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 | 10.1021/jm060012g | ||
53472113 | 118353 | 0 | None | -630 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 519 | 4 | 0 | 7 | 6.3 | C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 | 10.1021/jm5017413 | ||
CHEMBL3422009 | 118353 | 0 | None | -630 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 519 | 4 | 0 | 7 | 6.3 | C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 | 10.1021/jm5017413 | ||
2132 | 3687 | 48 | None | -1659 | 6 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 382 | 5 | 2 | 3 | 5.5 | CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 | 10.1021/jm5017413 | ||
5311424 | 3687 | 48 | None | -1659 | 6 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 382 | 5 | 2 | 3 | 5.5 | CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 | 10.1021/jm5017413 | ||
CHEMBL10188 | 3687 | 48 | None | -1659 | 6 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 382 | 5 | 2 | 3 | 5.5 | CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 | 10.1021/jm5017413 | ||
71533722 | 118355 | 0 | None | -891 | 5 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 421 | 3 | 0 | 7 | 4.7 | Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 | 10.1021/jm5017413 | ||
CHEMBL3422010 | 118355 | 0 | None | -891 | 5 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 421 | 3 | 0 | 7 | 4.7 | Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 | 10.1021/jm5017413 | ||
71549769 | 118363 | 0 | None | -3981 | 5 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 422 | 3 | 0 | 8 | 4.1 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 | 10.1021/jm5017413 | ||
CHEMBL3422018 | 118363 | 0 | None | -3981 | 5 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 422 | 3 | 0 | 8 | 4.1 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 | 10.1021/jm5017413 | ||
10813332 | 7692 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 447 | 6 | 2 | 2 | 5.0 | O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F | 10.1021/jm970499g | ||
CHEMBL108933 | 7692 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 447 | 6 | 2 | 2 | 5.0 | O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F | 10.1021/jm970499g | ||
71533722 | 118355 | 0 | None | -891 | 5 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 421 | 3 | 0 | 7 | 4.7 | Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 | nan | ||
CHEMBL3422010 | 118355 | 0 | None | -891 | 5 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 421 | 3 | 0 | 7 | 4.7 | Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 | nan | ||
10745123 | 10443 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 544 | 10 | 2 | 4 | 4.3 | COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL1169522 | 10443 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 544 | 10 | 2 | 4 | 4.3 | COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
44337200 | 9163 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 795 | 9 | 2 | 7 | 7.2 | O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL110766 | 9163 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 795 | 9 | 2 | 7 | 7.2 | O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 | 10.1016/s0960-894x(02)00645-5 | ||
44363984 | 35440 | 0 | None | 4 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 735 | 14 | 0 | 5 | 9.3 | C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL144011 | 35440 | 0 | None | 4 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 735 | 14 | 0 | 5 | 9.3 | C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(00)00702-2 | ||
44215306 | 36943 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 725 | 14 | 1 | 6 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL145302 | 36943 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 725 | 14 | 1 | 6 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44215303 | 118457 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 710 | 12 | 1 | 6 | 7.4 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL342341 | 118457 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 710 | 12 | 1 | 6 | 7.4 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44363952 | 120498 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 696 | 12 | 1 | 6 | 7.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL356508 | 120498 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 696 | 12 | 1 | 6 | 7.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
118730933 | 117654 | 0 | None | -389 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 698 | 15 | 7 | 7 | 1.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408519 | 117654 | 0 | None | -389 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 698 | 15 | 7 | 7 | 1.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
118730933 | 117654 | 0 | None | -389 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 698 | 15 | 7 | 7 | 1.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3408519 | 117654 | 0 | None | -389 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 698 | 15 | 7 | 7 | 1.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
56665366 | 65577 | 0 | None | 10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 792 | 14 | 2 | 5 | 8.5 | O=C(CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.08.027 | ||
CHEMBL1835843 | 65577 | 0 | None | 10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 792 | 14 | 2 | 5 | 8.5 | O=C(CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.08.027 | ||
44177570 | 60931 | 0 | None | -169 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1219 | 27 | 10 | 10 | 6.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766204 | 60931 | 0 | None | -169 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1219 | 27 | 10 | 10 | 6.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
44314873 | 203082 | 0 | None | 2 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 726 | 12 | 1 | 7 | 6.3 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL74918 | 203082 | 0 | None | 2 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 726 | 12 | 1 | 7 | 6.3 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
10395141 | 203117 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 726 | 13 | 1 | 7 | 6.2 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL75367 | 203117 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 726 | 13 | 1 | 7 | 6.2 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44282002 | 124986 | 0 | None | -4 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 657 | 13 | 1 | 8 | 6.3 | CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL36462 | 124986 | 0 | None | -4 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 657 | 13 | 1 | 8 | 6.3 | CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
76317390 | 104130 | 0 | None | 5 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 633 | 6 | 1 | 4 | 7.4 | Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL3104784 | 104130 | 0 | None | 5 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 633 | 6 | 1 | 4 | 7.4 | Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
10651193 | 7372 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 598 | 9 | 2 | 3 | 6.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL108676 | 7372 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 598 | 9 | 2 | 3 | 6.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
11273015 | 57957 | 0 | None | -21 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 563 | 8 | 1 | 3 | 6.0 | CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.bmcl.2010.12.135 | ||
CHEMBL1682624 | 57957 | 0 | None | -21 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 563 | 8 | 1 | 3 | 6.0 | CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1016/j.bmcl.2010.12.135 | ||
132837 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm900473p | ||
9461 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm900473p | ||
CHEMBL22870 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm900473p | ||
132837 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm800389v | ||
9461 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm800389v | ||
CHEMBL22870 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm800389v | ||
132837 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm070332f | ||
132837 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm101023r | ||
9461 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm070332f | ||
9461 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm101023r | ||
CHEMBL22870 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm070332f | ||
CHEMBL22870 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm101023r | ||
2110 | 2922 | 33 | None | -1258 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm9602423 | ||
219077 | 2922 | 33 | None | -1258 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm9602423 | ||
3480 | 2922 | 33 | None | -1258 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm9602423 | ||
CHEMBL346178 | 2922 | 33 | None | -1258 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm9602423 | ||
DB04872 | 2922 | 33 | None | -1258 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm9602423 | ||
2110 | 2922 | 33 | None | -1258 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm980633c | ||
219077 | 2922 | 33 | None | -1258 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm980633c | ||
3480 | 2922 | 33 | None | -1258 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm980633c | ||
CHEMBL346178 | 2922 | 33 | None | -1258 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm980633c | ||
DB04872 | 2922 | 33 | None | -1258 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm980633c | ||
44318665 | 105670 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 531 | 3 | 1 | 4 | 5.2 | CSc1ccc(N2C(=O)NC3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2=O)cc1 | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL313590 | 105670 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 531 | 3 | 1 | 4 | 5.2 | CSc1ccc(N2C(=O)NC3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2=O)cc1 | 10.1016/s0960-894x(02)00488-2 | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm061369n | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm061369n | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1021/jm061369n | ||
132837 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2009.08.035 | ||
9461 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL22870 | 2207 | 51 | None | -18 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 10.1016/j.bmc.2009.08.035 | ||
44337514 | 5213 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 406 | 6 | 1 | 4 | 2.8 | CN1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL106555 | 5213 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 406 | 6 | 1 | 4 | 2.8 | CN1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
15887536 | 5356 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 646 | 8 | 1 | 4 | 5.9 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL107309 | 5356 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 646 | 8 | 1 | 4 | 5.9 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
54397413 | 90635 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 325 | 7 | 3 | 3 | 1.0 | CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm400209h | ||
CHEMBL2397486 | 90635 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 325 | 7 | 3 | 3 | 1.0 | CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm400209h | ||
44314453 | 96637 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 758 | 13 | 1 | 6 | 8.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CCc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL267333 | 96637 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 758 | 13 | 1 | 6 | 8.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CCc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44314732 | 203385 | 0 | None | 3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 764 | 12 | 0 | 6 | 8.5 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL77592 | 203385 | 0 | None | 3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 764 | 12 | 0 | 6 | 8.5 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44318694 | 105546 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 575 | 4 | 1 | 3 | 6.1 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1cccc(-c3ccccc3)c1)C2=O | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL313297 | 105546 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 575 | 4 | 1 | 3 | 6.1 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1cccc(-c3ccccc3)c1)C2=O | 10.1016/s0960-894x(02)00488-2 | ||
44408864 | 76168 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 451 | 4 | 1 | 1 | 7.3 | CC(C)(C(=O)Nc1ccccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL206016 | 76168 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 451 | 4 | 1 | 1 | 7.3 | CC(C)(C(=O)Nc1ccccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
44363990 | 16136 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 749 | 14 | 0 | 5 | 9.5 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL122643 | 16136 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 749 | 14 | 0 | 5 | 9.5 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44363982 | 35438 | 0 | None | 2 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 683 | 12 | 0 | 6 | 7.8 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL144010 | 35438 | 0 | None | 2 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 683 | 12 | 0 | 6 | 7.8 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44363442 | 37707 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 697 | 12 | 1 | 6 | 8.0 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL145959 | 37707 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 697 | 12 | 1 | 6 | 8.0 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
24768353 | 97299 | 0 | None | -21 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 941 | 22 | 9 | 9 | 2.7 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 | 10.1021/jm070332f | ||
CHEMBL271619 | 97299 | 0 | None | -21 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 941 | 22 | 9 | 9 | 2.7 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 | 10.1021/jm070332f | ||
44233185 | 193154 | 0 | None | -181 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1327 | 29 | 14 | 16 | 1.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL539193 | 193154 | 0 | None | -181 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1327 | 29 | 14 | 16 | 1.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
10394952 | 104270 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 696 | 12 | 0 | 6 | 7.0 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL310703 | 104270 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 696 | 12 | 0 | 6 | 7.0 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44314486 | 105176 | 0 | None | 6 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 739 | 13 | 0 | 7 | 6.5 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL312528 | 105176 | 0 | None | 6 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 739 | 13 | 0 | 7 | 6.5 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
9987474 | 203125 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 726 | 13 | 1 | 7 | 6.2 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL75436 | 203125 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 726 | 13 | 1 | 7 | 6.2 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44177670 | 60933 | 0 | None | -190 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1151 | 27 | 10 | 10 | 5.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766206 | 60933 | 0 | None | -190 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1151 | 27 | 10 | 10 | 5.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
44281345 | 109991 | 0 | None | -10 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 554 | 11 | 1 | 5 | 7.0 | CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL32477 | 109991 | 0 | None | -10 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 554 | 11 | 1 | 5 | 7.0 | CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44337353 | 5355 | 0 | None | -9 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 635 | 7 | 2 | 5 | 4.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL107306 | 5355 | 0 | None | -9 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 635 | 7 | 2 | 5 | 4.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL388265 | 210668 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O | 10.1021/jm901352b | ||||
44318677 | 203981 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 531 | 3 | 0 | 3 | 4.9 | CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3ccccc3F)CC2)C1=O | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL82278 | 203981 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 531 | 3 | 0 | 3 | 4.9 | CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3ccccc3F)CC2)C1=O | 10.1016/s0960-894x(02)00488-2 | ||
44337080 | 110109 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 945 | 11 | 2 | 7 | 8.8 | CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccc(Cl)c(Cl)c2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL325547 | 110109 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 945 | 11 | 2 | 7 | 8.8 | CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccc(Cl)c(Cl)c2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 | 10.1016/s0960-894x(02)00645-5 | ||
44380313 | 57785 | 0 | None | 15 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 647 | 10 | 1 | 4 | 8.3 | O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL167409 | 57785 | 0 | None | 15 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 647 | 10 | 1 | 4 | 8.3 | O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380095 | 120343 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 687 | 11 | 1 | 6 | 8.6 | N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL355868 | 120343 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 687 | 11 | 1 | 6 | 8.6 | N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44337174 | 7801 | 0 | None | -11 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 649 | 8 | 2 | 5 | 5.8 | CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL108997 | 7801 | 0 | None | -11 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 649 | 8 | 2 | 5 | 5.8 | CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1016/s0960-894x(02)00645-5 | ||
9566253 | 75159 | 1 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 414 | 4 | 1 | 5 | 6.1 | Cc1onc(-c2c(Cl)cccc2Cl)c1/C=N/Nc1c(Cl)cncc1Cl | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL204327 | 75159 | 1 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 414 | 4 | 1 | 5 | 6.1 | Cc1onc(-c2c(Cl)cccc2Cl)c1/C=N/Nc1c(Cl)cncc1Cl | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL3609617 | 210084 | 0 | None | -501 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||||
73212437 | 104132 | 0 | None | 630 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 559 | 8 | 1 | 4 | 4.7 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL3104786 | 104132 | 0 | None | 630 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 559 | 8 | 1 | 4 | 4.7 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 | 10.1016/j.bmcl.2013.12.033 | ||
90644632 | 111454 | 0 | None | 7 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 698 | 12 | 3 | 6 | 5.6 | CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288168 | 111454 | 0 | None | 7 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 698 | 12 | 3 | 6 | 5.6 | CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
90644628 | 112237 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 697 | 12 | 3 | 6 | 5.4 | CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 | 10.1021/ml400528y | ||
CHEMBL3288165 | 112237 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 697 | 12 | 3 | 6 | 5.4 | CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 | 10.1021/ml400528y | ||
CHEMBL3304854 | 112237 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 697 | 12 | 3 | 6 | 5.4 | CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 | 10.1021/ml400528y | ||
10141196 | 26595 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 490 | 8 | 1 | 4 | 4.7 | O=C(O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL136291 | 26595 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 490 | 8 | 1 | 4 | 4.7 | O=C(O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
135530616 | 29578 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 529 | 8 | 2 | 6 | 4.6 | Oc1n[nH]c(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)CC2)n1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL138716 | 29578 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 529 | 8 | 2 | 6 | 4.6 | Oc1n[nH]c(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)CC2)n1 | 10.1016/s0960-894x(02)00956-3 | ||
10230370 | 30379 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 534 | 11 | 1 | 5 | 4.7 | O=C(O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL139382 | 30379 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 534 | 11 | 1 | 5 | 4.7 | O=C(O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
44358408 | 30755 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 545 | 9 | 0 | 5 | 4.9 | FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCN3CCOCC3)CC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL139859 | 30755 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 545 | 9 | 0 | 5 | 4.9 | FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCN3CCOCC3)CC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
44358597 | 31245 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 432 | 6 | 1 | 3 | 4.9 | FC(F)(F)c1ccc(COCC(c2ccccc2)N2CCNCC2)c(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL140302 | 31245 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 432 | 6 | 1 | 3 | 4.9 | FC(F)(F)c1ccc(COCC(c2ccccc2)N2CCNCC2)c(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
9852911 | 98924 | 0 | None | 8 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 678 | 20 | 2 | 7 | 7.4 | NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 | 10.1021/jm0205088 | ||
CHEMBL282618 | 98924 | 0 | None | 8 | 6 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 678 | 20 | 2 | 7 | 7.4 | NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 | 10.1021/jm0205088 | ||
10085946 | 164788 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 296 | 7 | 2 | 3 | 3.3 | CNC(c1ccccc1)C1(NCc2ccccc2OC)CC1 | 10.1016/s0960-894x(01)00020-8 | ||
CHEMBL423597 | 164788 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 296 | 7 | 2 | 3 | 3.3 | CNC(c1ccccc1)C1(NCc2ccccc2OC)CC1 | 10.1016/s0960-894x(01)00020-8 | ||
25222441 | 195465 | 0 | None | -30 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 589 | 8 | 0 | 3 | 6.4 | CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm900948q | ||
CHEMBL567849 | 195465 | 0 | None | -30 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 589 | 8 | 0 | 3 | 6.4 | CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm900948q | ||
118730936 | 117657 | 0 | None | -16982 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 684 | 14 | 7 | 7 | 1.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2ccccc2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408522 | 117657 | 0 | None | -16982 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 684 | 14 | 7 | 7 | 1.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2ccccc2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
10552479 | 108516 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 474 | 7 | 2 | 4 | 4.8 | O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
CHEMBL321215 | 108516 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 474 | 7 | 2 | 4 | 4.8 | O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
44315267 | 105026 | 0 | None | -63 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 701 | 11 | 1 | 7 | 8.5 | CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL312141 | 105026 | 0 | None | -63 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 701 | 11 | 1 | 7 | 8.5 | CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44358421 | 29539 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 422 | 6 | 1 | 4 | 4.5 | FC(F)(F)c1cc(COCC(c2ccco2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL138682 | 29539 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 422 | 6 | 1 | 4 | 4.5 | FC(F)(F)c1cc(COCC(c2ccco2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
44363962 | 35701 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 753 | 14 | 0 | 7 | 8.7 | CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL144249 | 35701 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 753 | 14 | 0 | 7 | 8.7 | CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/s0960-894x(00)00702-2 | ||
44363949 | 120429 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 683 | 11 | 0 | 5 | 8.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL356105 | 120429 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 683 | 11 | 0 | 5 | 8.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44314502 | 203089 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 712 | 12 | 1 | 7 | 5.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL75018 | 203089 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 712 | 12 | 1 | 7 | 5.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
10531434 | 7378 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 587 | 9 | 3 | 3 | 5.5 | CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL108683 | 7378 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 587 | 9 | 3 | 3 | 5.5 | CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
51351504 | 60285 | 1 | None | -4 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 410 | 4 | 0 | 5 | 3.7 | COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 | 10.1016/j.bmcl.2011.02.033 | ||
CHEMBL1760206 | 60285 | 1 | None | -4 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 410 | 4 | 0 | 5 | 3.7 | COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 | 10.1016/j.bmcl.2011.02.033 | ||
118731119 | 117672 | 0 | None | -162181 | 2 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 686 | 17 | 7 | 7 | 1.5 | Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1ccccc1 | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408736 | 117672 | 0 | None | -162181 | 2 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 686 | 17 | 7 | 7 | 1.5 | Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1ccccc1 | 10.1016/j.ejmech.2014.12.033 | ||
44351946 | 116866 | 1 | None | -1778 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 568 | 8 | 0 | 3 | 7.3 | CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm020094i | ||
CHEMBL339767 | 116866 | 1 | None | -1778 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 568 | 8 | 0 | 3 | 7.3 | CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm020094i | ||
44281784 | 112994 | 0 | None | -6 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 690 | 10 | 1 | 6 | 8.3 | CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL33198 | 112994 | 0 | None | -6 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 690 | 10 | 1 | 6 | 8.3 | CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44318865 | 204420 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 671 | 7 | 0 | 7 | 3.8 | COc1ccc(N2CN(CC(=O)N3CCC4(CC3)C(=O)N(C)C(=O)N4Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2=O)cc1OC | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL86053 | 204420 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 671 | 7 | 0 | 7 | 3.8 | COc1ccc(N2CN(CC(=O)N3CCC4(CC3)C(=O)N(C)C(=O)N4Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2=O)cc1OC | 10.1016/s0960-894x(02)00488-2 | ||
44380094 | 58436 | 0 | None | 3 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 719 | 13 | 2 | 6 | 7.6 | NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL168584 | 58436 | 0 | None | 3 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 719 | 13 | 2 | 6 | 7.6 | NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
141952732 | 119959 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 734 | 13 | 3 | 7 | 7.8 | N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O | 10.1016/s0960-894x(02)00027-6 | ||
44380527 | 119959 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 734 | 13 | 3 | 7 | 7.8 | N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL354091 | 119959 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 734 | 13 | 3 | 7 | 7.8 | N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O | 10.1016/s0960-894x(02)00027-6 | ||
44337467 | 109726 | 0 | None | 17 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 821 | 13 | 2 | 7 | 7.8 | O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL323741 | 109726 | 0 | None | 17 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 821 | 13 | 2 | 7 | 7.8 | O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 | 10.1016/s0960-894x(02)00645-5 | ||
44363936 | 19835 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 782 | 14 | 1 | 7 | 9.0 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL130354 | 19835 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 782 | 14 | 1 | 7 | 9.0 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
9868422 | 169712 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 451 | 4 | 0 | 1 | 7.0 | Cc1ccccc1-c1ccccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL444624 | 169712 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 451 | 4 | 0 | 1 | 7.0 | Cc1ccccc1-c1ccccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
10507771 | 109250 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 598 | 9 | 2 | 3 | 6.1 | CN(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL322975 | 109250 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 598 | 9 | 2 | 3 | 6.1 | CN(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
73353537 | 90639 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 325 | 7 | 3 | 3 | 1.3 | C[C@@H](c1ccccc1)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
CHEMBL2397490 | 90639 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 325 | 7 | 3 | 3 | 1.3 | C[C@@H](c1ccccc1)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
10790280 | 108132 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 463 | 6 | 2 | 2 | 5.1 | O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL320583 | 108132 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 463 | 6 | 2 | 2 | 5.1 | O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl | 10.1021/jm970499g | ||
10649307 | 109879 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 507 | 6 | 2 | 2 | 5.2 | O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Br | 10.1021/jm970499g | ||
CHEMBL324177 | 109879 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 507 | 6 | 2 | 2 | 5.2 | O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Br | 10.1021/jm970499g | ||
10531273 | 9109 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 578 | 9 | 3 | 4 | 4.9 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(=O)O | 10.1021/jm970499g | ||
CHEMBL110393 | 9109 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 578 | 9 | 3 | 4 | 4.9 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(=O)O | 10.1021/jm970499g | ||
71549913 | 118351 | 0 | None | -1737 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 415 | 3 | 0 | 6 | 4.6 | Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 | nan | ||
CHEMBL3422007 | 118351 | 0 | None | -1737 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 415 | 3 | 0 | 6 | 4.6 | Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 | nan | ||
44408725 | 165515 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 375 | 4 | 1 | 3 | 6.2 | Clc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL425768 | 165515 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 375 | 4 | 1 | 3 | 6.2 | Clc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl | 10.1016/j.bmcl.2005.11.047 | ||
7088456 | 197846 | 1 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 | 10.1021/jm901352b | ||
CHEMBL592133 | 197846 | 1 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 | 10.1021/jm901352b | ||
44363908 | 35555 | 0 | None | -4 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 681 | 11 | 0 | 5 | 8.2 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL144116 | 35555 | 0 | None | -4 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 681 | 11 | 0 | 5 | 8.2 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44363756 | 39597 | 0 | None | 8 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 703 | 12 | 1 | 5 | 8.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL147715 | 39597 | 0 | None | 8 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 703 | 12 | 1 | 5 | 8.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44138558 | 192436 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 477 | 3 | 1 | 2 | 5.4 | Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
CHEMBL522292 | 192436 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 477 | 3 | 1 | 2 | 5.4 | Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
10189341 | 10024 | 0 | None | 10 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 623 | 7 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1021/jm030786m | ||
CHEMBL115633 | 10024 | 0 | None | 10 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 623 | 7 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1021/jm030786m | ||
10746177 | 6945 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 602 | 8 | 2 | 3 | 6.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(F)(F)F | 10.1021/jm970499g | ||
CHEMBL108481 | 6945 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 602 | 8 | 2 | 3 | 6.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(F)(F)F | 10.1021/jm970499g | ||
11100291 | 177103 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 353 | 8 | 3 | 3 | 0.9 | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm901352b | ||
CHEMBL464178 | 177103 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 353 | 8 | 3 | 3 | 0.9 | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm901352b | ||
10649931 | 7793 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 531 | 9 | 3 | 3 | 4.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL108990 | 7793 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 531 | 9 | 3 | 3 | 4.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL2371916 | 208407 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O | 10.1021/jm00391a046 | ||||
20906619 | 60344 | 7 | None | -7 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 396 | 4 | 1 | 4 | 3.7 | COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 | 10.1016/j.bmcl.2011.02.033 | ||
CHEMBL1760338 | 60344 | 7 | None | -7 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 396 | 4 | 1 | 4 | 3.7 | COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 | 10.1016/j.bmcl.2011.02.033 | ||
73353047 | 88976 | 0 | None | 1 | 2 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 746 | 6 | 8 | 9 | -1.1 | COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 | 10.1021/jm00029a007 | ||
CHEMBL2370509 | 88976 | 0 | None | 1 | 2 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 746 | 6 | 8 | 9 | -1.1 | COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 | 10.1021/jm00029a007 | ||
44314547 | 102402 | 0 | None | 5 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 661 | 11 | 0 | 5 | 8.5 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL305826 | 102402 | 0 | None | 5 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 661 | 11 | 0 | 5 | 8.5 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
25221995 | 195176 | 0 | None | -67 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 601 | 8 | 0 | 3 | 6.5 | CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm900948q | ||
CHEMBL565894 | 195176 | 0 | None | -67 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 601 | 8 | 0 | 3 | 6.5 | CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm900948q | ||
46228976 | 197465 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 297 | 6 | 3 | 3 | 0.9 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)c1ccccc1 | 10.1021/jm901352b | ||
CHEMBL589329 | 197465 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 297 | 6 | 3 | 3 | 0.9 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)c1ccccc1 | 10.1021/jm901352b | ||
15487997 | 90631 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 325 | 8 | 3 | 3 | 1.0 | CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
CHEMBL2397482 | 90631 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 325 | 8 | 3 | 3 | 1.0 | CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
44363925 | 39823 | 0 | None | 3 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 754 | 13 | 1 | 7 | 8.4 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL147924 | 39823 | 0 | None | 3 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 754 | 13 | 1 | 7 | 8.4 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44314871 | 105213 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 712 | 12 | 0 | 7 | 6.2 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL312573 | 105213 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 712 | 12 | 0 | 7 | 6.2 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
90644630 | 111452 | 0 | None | 50 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 725 | 13 | 2 | 6 | 6.2 | CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 | 10.1021/ml400528y | ||
CHEMBL3288166 | 111452 | 0 | None | 50 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 725 | 13 | 2 | 6 | 6.2 | CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 | 10.1021/ml400528y | ||
90644620 | 112294 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288161 | 112294 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3305870 | 112294 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
44407901 | 139914 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 701 | 10 | 1 | 6 | 6.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL380928 | 139914 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 701 | 10 | 1 | 6 | 6.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
44358409 | 118837 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 475 | 6 | 1 | 3 | 4.7 | NC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL344265 | 118837 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 475 | 6 | 1 | 3 | 4.7 | NC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
46224928 | 197721 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 515 | 2 | 1 | 2 | 6.2 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
CHEMBL591074 | 197721 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 515 | 2 | 1 | 2 | 6.2 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
54583959 | 60345 | 0 | None | -3 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 410 | 5 | 1 | 4 | 3.7 | COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 | 10.1016/j.bmcl.2011.02.033 | ||
CHEMBL1760339 | 60345 | 0 | None | -3 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 410 | 5 | 1 | 4 | 3.7 | COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 | 10.1016/j.bmcl.2011.02.033 | ||
90644606 | 112293 | 0 | None | 6 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 683 | 11 | 2 | 6 | 5.3 | CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288154 | 112293 | 0 | None | 6 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 683 | 11 | 2 | 6 | 5.3 | CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3305869 | 112293 | 0 | None | 6 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 683 | 11 | 2 | 6 | 5.3 | CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
44338530 | 9267 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 332 | 6 | 1 | 3 | 3.1 | Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL111303 | 9267 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 332 | 6 | 1 | 3 | 3.1 | Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
11239751 | 84747 | 0 | None | -1995 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 785 | 10 | 7 | 8 | -0.5 | NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 | 10.1021/jm040832y | ||
CHEMBL225297 | 84747 | 0 | None | -1995 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 785 | 10 | 7 | 8 | -0.5 | NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 | 10.1021/jm040832y | ||
44322610 | 204919 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 462 | 5 | 1 | 2 | 5.6 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 | 10.1021/jm058225d | ||
CHEMBL89245 | 204919 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 462 | 5 | 1 | 2 | 5.6 | O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 | 10.1021/jm058225d | ||
86274490 | 159339 | 0 | None | -1000 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 392 | 2 | 0 | 7 | 3.1 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 | nan | ||
CHEMBL4106866 | 159339 | 0 | None | -1000 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 392 | 2 | 0 | 7 | 3.1 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 | nan | ||
44315210 | 102445 | 0 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 747 | 14 | 0 | 8 | 8.0 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL306124 | 102445 | 0 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 747 | 14 | 0 | 8 | 8.0 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44409023 | 139688 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL380510 | 139688 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 578 | 5 | 0 | 4 | 6.8 | Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
44560754 | 172626 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 445 | 5 | 1 | 2 | 5.9 | C[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL452269 | 172626 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 445 | 5 | 1 | 2 | 5.9 | C[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.05.082 | ||
10359664 | 113503 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 336 | 3 | 2 | 3 | 4.0 | COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 | 10.1021/jm00051a001 | ||
CHEMBL332644 | 113503 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 336 | 3 | 2 | 3 | 4.0 | COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 | 10.1021/jm00051a001 | ||
9896563 | 103304 | 0 | None | 5 | 2 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL308891 | 103304 | 0 | None | 5 | 2 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 711 | 12 | 1 | 6 | 6.4 | CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O | 10.1016/s0960-894x(02)00340-2 | ||
9810288 | 201996 | 0 | None | 8 | 2 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 697 | 12 | 1 | 6 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL67508 | 201996 | 0 | None | 8 | 2 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 697 | 12 | 1 | 6 | 6.1 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
44281633 | 99525 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 664 | 11 | 1 | 7 | 7.7 | CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL286646 | 99525 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 664 | 11 | 1 | 7 | 7.7 | CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44281649 | 108533 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 625 | 11 | 1 | 7 | 6.0 | CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL32124 | 108533 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 625 | 11 | 1 | 7 | 6.0 | CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44281666 | 108718 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 635 | 10 | 1 | 5 | 7.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL32163 | 108718 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 635 | 10 | 1 | 5 | 7.5 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44281650 | 113298 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 651 | 11 | 1 | 7 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL33243 | 113298 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 651 | 11 | 1 | 7 | 6.5 | CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
10394882 | 113313 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 689 | 10 | 2 | 5 | 7.9 | CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL33249 | 113313 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 689 | 10 | 2 | 5 | 7.9 | CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
52943090 | 17977 | 0 | None | 79 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 666 | 5 | 0 | 4 | 4.8 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2010.08.138 | ||
CHEMBL1269640 | 17977 | 0 | None | 79 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 666 | 5 | 0 | 4 | 4.8 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@@H]1c1ccc(F)cc1 | 10.1016/j.bmcl.2010.08.138 | ||
71453994 | 83121 | 0 | None | 10 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 583 | 5 | 1 | 4 | 6.7 | Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203706 | 83121 | 0 | None | 10 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 583 | 5 | 1 | 4 | 6.7 | Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
44380413 | 96148 | 0 | None | 21 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 741 | 15 | 1 | 7 | 6.2 | COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL263214 | 96148 | 0 | None | 21 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 741 | 15 | 1 | 7 | 6.2 | COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380249 | 119838 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 706 | 12 | 1 | 6 | 7.3 | CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL353027 | 119838 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 706 | 12 | 1 | 6 | 7.3 | CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
127034831 | 135990 | 0 | None | -2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1120 | 22 | 8 | 9 | 5.7 | Cc1cc(O)cc(C)c1CC(N)C(=O)NC(C)C(=O)NCC(=O)N(C)C(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.1c01456 | ||
CHEMBL3736287 | 135990 | 0 | None | -2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1120 | 22 | 8 | 9 | 5.7 | Cc1cc(O)cc(C)c1CC(N)C(=O)NC(C)C(=O)NCC(=O)N(C)C(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.1c01456 | ||
72734611 | 90553 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 337 | 5 | 2 | 3 | 1.4 | NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 | 10.1021/ml5002954 | ||
CHEMBL2396664 | 90553 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 337 | 5 | 2 | 3 | 1.4 | NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 | 10.1021/ml5002954 | ||
72734611 | 90553 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 337 | 5 | 2 | 3 | 1.4 | NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 | 10.1021/ml5002954 | ||
CHEMBL2396664 | 90553 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 337 | 5 | 2 | 3 | 1.4 | NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 | 10.1021/ml5002954 | ||
127032846 | 138262 | 0 | None | 4 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1081 | 24 | 9 | 9 | 5.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3780818 | 138262 | 0 | None | 4 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1081 | 24 | 9 | 9 | 5.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1021/acsmedchemlett.5b00359 | ||
145948744 | 166914 | 0 | None | -2 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1120 | 22 | 8 | 9 | 5.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299371 | 166914 | 0 | None | -2 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1120 | 22 | 8 | 9 | 5.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
72734611 | 90553 | 0 | None | -1 | 2 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 337 | 5 | 2 | 3 | 1.4 | NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 | 10.1016/j.bmcl.2018.06.009 | ||
CHEMBL2396664 | 90553 | 0 | None | -1 | 2 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 337 | 5 | 2 | 3 | 1.4 | NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 | 10.1016/j.bmcl.2018.06.009 | ||
72734611 | 90553 | 0 | None | -1 | 2 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 337 | 5 | 2 | 3 | 1.4 | NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm400209h | ||
CHEMBL2396664 | 90553 | 0 | None | -1 | 2 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 337 | 5 | 2 | 3 | 1.4 | NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm400209h | ||
10769060 | 5957 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 552 | 8 | 2 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 | 10.1021/jm970499g | ||
CHEMBL108040 | 5957 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 552 | 8 | 2 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 | 10.1021/jm970499g | ||
11353915 | 6875 | 0 | None | 2 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 601 | 9 | 1 | 4 | 7.6 | CCCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1084525 | 6875 | 0 | None | 2 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 601 | 9 | 1 | 4 | 7.6 | CCCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 | 10.1016/j.bmcl.2010.04.008 | ||
46889692 | 6850 | 0 | None | 12 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 613 | 6 | 1 | 4 | 7.7 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1084435 | 6850 | 0 | None | 12 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 613 | 6 | 1 | 4 | 7.7 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@@H]2CO)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
44315209 | 203203 | 0 | None | 1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 728 | 12 | 0 | 8 | 7.9 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL76093 | 203203 | 0 | None | 1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 728 | 12 | 0 | 8 | 7.9 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44178113 | 60935 | 0 | None | -12 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1237 | 27 | 10 | 11 | 5.6 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
CHEMBL1766208 | 60935 | 0 | None | -12 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1237 | 27 | 10 | 11 | 5.6 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm101023r | ||
10793340 | 5648 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 579 | 9 | 2 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc([N+](=O)[O-])c1 | 10.1021/jm970499g | ||
CHEMBL107830 | 5648 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 579 | 9 | 2 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc([N+](=O)[O-])c1 | 10.1021/jm970499g | ||
10817098 | 110039 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 582 | 9 | 2 | 3 | 5.6 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL325106 | 110039 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 582 | 9 | 2 | 3 | 5.6 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl | 10.1021/jm970499g | ||
44380090 | 120208 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 684 | 13 | 0 | 6 | 7.0 | COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL354771 | 120208 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 684 | 13 | 0 | 6 | 7.0 | COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44315422 | 102664 | 0 | None | 2 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 747 | 13 | 1 | 8 | 7.5 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL307877 | 102664 | 0 | None | 2 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 747 | 13 | 1 | 8 | 7.5 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44315591 | 203266 | 0 | None | 1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 746 | 13 | 1 | 8 | 6.9 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL76529 | 203266 | 0 | None | 1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 746 | 13 | 1 | 8 | 6.9 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44315299 | 203302 | 0 | None | -1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 737 | 12 | 0 | 6 | 8.4 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL76823 | 203302 | 0 | None | -1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 737 | 12 | 0 | 6 | 8.4 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
9940831 | 14477 | 0 | None | 1 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 810 | 13 | 4 | 9 | 5.7 | O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 | 10.1016/S0960-894X(96)00604-X | ||
CHEMBL1205204 | 14477 | 0 | None | 1 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 810 | 13 | 4 | 9 | 5.7 | O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 | 10.1016/S0960-894X(96)00604-X | ||
CHEMBL65468 | 14477 | 0 | None | 1 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 810 | 13 | 4 | 9 | 5.7 | O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 | 10.1016/S0960-894X(96)00604-X | ||
10237920 | 79432 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 416 | 5 | 0 | 2 | 6.1 | C[C@@H](OCC1(c2ccccc2)CC(=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL212173 | 79432 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 416 | 5 | 0 | 2 | 6.1 | C[C@@H](OCC1(c2ccccc2)CC(=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
9927183 | 193932 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 322 | 5 | 2 | 3 | 3.7 | COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 | 10.1016/S0960-894X(01)80386-3 | ||
CHEMBL55591 | 193932 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 322 | 5 | 2 | 3 | 3.7 | COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 | 10.1016/S0960-894X(01)80386-3 | ||
44315572 | 102508 | 0 | None | 1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 689 | 11 | 1 | 7 | 8.3 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL306624 | 102508 | 0 | None | 1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 689 | 11 | 1 | 7 | 8.3 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
145948965 | 166927 | 0 | None | 1 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1183 | 22 | 9 | 9 | 6.1 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299476 | 166927 | 0 | None | 1 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1183 | 22 | 9 | 9 | 6.1 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
11794060 | 118693 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 378 | 6 | 2 | 7 | 2.5 | COc1ccc(-c2nnn(C)n2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
CHEMBL343219 | 118693 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 378 | 6 | 2 | 7 | 2.5 | COc1ccc(-c2nnn(C)n2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 10.1021/jm00026a005 | ||
86302473 | 112251 | 0 | None | 3 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 697 | 11 | 2 | 6 | 5.5 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288169 | 112251 | 0 | None | 3 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 697 | 11 | 2 | 6 | 5.5 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3305156 | 112251 | 0 | None | 3 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 697 | 11 | 2 | 6 | 5.5 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
44408040 | 74070 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 637 | 7 | 1 | 6 | 5.1 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL202627 | 74070 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 637 | 7 | 1 | 6 | 5.1 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
9874480 | 74424 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 661 | 9 | 3 | 4 | 6.1 | COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL203113 | 74424 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 661 | 9 | 3 | 4 | 6.1 | COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2005.10.077 | ||
44407908 | 140027 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 687 | 9 | 1 | 7 | 4.7 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL381155 | 140027 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 687 | 9 | 1 | 7 | 4.7 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 | 10.1016/j.bmcl.2005.10.077 | ||
44358317 | 116037 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 488 | 9 | 0 | 3 | 6.4 | CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL336251 | 116037 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 488 | 9 | 0 | 3 | 6.4 | CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
44358425 | 164894 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 548 | 11 | 1 | 5 | 5.3 | C[C@H](OC[C@@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL423913 | 164894 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 548 | 11 | 1 | 5 | 5.3 | C[C@H](OC[C@@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
145948839 | 166918 | 0 | None | -6 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1137 | 22 | 8 | 9 | 5.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299415 | 166918 | 0 | None | -6 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1137 | 22 | 8 | 9 | 5.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
44560774 | 172401 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 524 | 7 | 2 | 4 | 4.1 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
CHEMBL451764 | 172401 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 524 | 7 | 2 | 4 | 4.1 | C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.05.082 | ||
73348949 | 90391 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 494 | 5 | 1 | 2 | 6.0 | Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
CHEMBL2392023 | 90391 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 494 | 5 | 1 | 2 | 6.0 | Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2013.01.025 | ||
10816496 | 5132 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 550 | 8 | 3 | 4 | 4.9 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1O | 10.1021/jm970499g | ||
CHEMBL106100 | 5132 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 550 | 8 | 3 | 4 | 4.9 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1O | 10.1021/jm970499g | ||
46889669 | 6933 | 0 | None | 2 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 585 | 5 | 1 | 4 | 7.0 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@@H](O)C2)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1084771 | 6933 | 0 | None | 2 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 585 | 5 | 1 | 4 | 7.0 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@@H](O)C2)cc1-c1ccccc1Cl | 10.1016/j.bmcl.2010.04.008 | ||
44315231 | 104920 | 0 | None | 1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 780 | 13 | 0 | 8 | 8.8 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL311712 | 104920 | 0 | None | 1 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 780 | 13 | 0 | 8 | 8.8 | CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44408062 | 140026 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 436 | 5 | 2 | 2 | 4.6 | O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL381151 | 140026 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 436 | 5 | 2 | 2 | 4.6 | O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 | 10.1016/j.bmcl.2005.10.072 | ||
10600310 | 85932 | 0 | None | 13 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 466 | 7 | 0 | 5 | 4.9 | C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cccc(Cl)c3)CC2)c2ccccc21 | 10.1021/jm301653f | ||
CHEMBL2313628 | 85932 | 0 | None | 13 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 466 | 7 | 0 | 5 | 4.9 | C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cccc(Cl)c3)CC2)c2ccccc21 | 10.1021/jm301653f | ||
44380248 | 57855 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 720 | 13 | 0 | 7 | 7.3 | CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL168144 | 57855 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 720 | 13 | 0 | 7 | 7.3 | CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
71457524 | 83120 | 0 | None | -5 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 597 | 6 | 1 | 4 | 7.1 | Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL2203705 | 83120 | 0 | None | -5 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 597 | 6 | 1 | 4 | 7.1 | Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm2017072 | ||
CHEMBL3609619 | 210086 | 0 | None | 34 | 3 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||||
145948981 | 166930 | 0 | None | 1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1139 | 22 | 9 | 9 | 6.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299483 | 166930 | 0 | None | 1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1139 | 22 | 9 | 9 | 6.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
9874473 | 41564 | 0 | None | 16 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 659 | 10 | 0 | 4 | 8.4 | CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm030197g | ||
CHEMBL149326 | 41564 | 0 | None | 16 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 659 | 10 | 0 | 4 | 8.4 | CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm030197g | ||
44380732 | 58683 | 0 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 706 | 13 | 2 | 6 | 8.1 | OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL169002 | 58683 | 0 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 706 | 13 | 2 | 6 | 8.1 | OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44363436 | 35487 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 711 | 12 | 0 | 5 | 9.2 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL144057 | 35487 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 711 | 12 | 0 | 5 | 9.2 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44363979 | 120470 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 711 | 13 | 1 | 6 | 8.3 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL356268 | 120470 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 711 | 13 | 1 | 6 | 8.3 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
10484667 | 202849 | 0 | None | -2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
CHEMBL72930 | 202849 | 0 | None | -2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
CHEMBL2370435 | 208104 | 0 | None | -48 | 2 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O | 10.1021/jm00073a022 | ||||
44314578 | 203438 | 0 | None | 13 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 726 | 14 | 1 | 7 | 6.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL78091 | 203438 | 0 | None | 13 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 726 | 14 | 1 | 7 | 6.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
13821356 | 106238 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 995 | 25 | 10 | 16 | 0.5 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)C(N)=O | 10.1021/jm00391a046 | ||
CHEMBL3144091 | 106238 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 995 | 25 | 10 | 16 | 0.5 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)C(N)=O | 10.1021/jm00391a046 | ||
44318578 | 203979 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 521 | 8 | 1 | 3 | 5.6 | CCCCCCCCN1C(=O)NC2(CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)C1=O | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL82274 | 203979 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 521 | 8 | 1 | 3 | 5.6 | CCCCCCCCN1C(=O)NC2(CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)C1=O | 10.1016/s0960-894x(02)00488-2 | ||
2110 | 2922 | 33 | None | -1258 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm900948q | ||
219077 | 2922 | 33 | None | -1258 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm900948q | ||
3480 | 2922 | 33 | None | -1258 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm900948q | ||
CHEMBL346178 | 2922 | 33 | None | -1258 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm900948q | ||
DB04872 | 2922 | 33 | None | -1258 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm900948q | ||
2110 | 2922 | 33 | None | -1258 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm2017072 | ||
219077 | 2922 | 33 | None | -1258 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm2017072 | ||
3480 | 2922 | 33 | None | -1258 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm2017072 | ||
CHEMBL346178 | 2922 | 33 | None | -1258 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm2017072 | ||
DB04872 | 2922 | 33 | None | -1258 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm2017072 | ||
44337330 | 5260 | 0 | None | -6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 649 | 8 | 2 | 5 | 4.8 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL106816 | 5260 | 0 | None | -6 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 649 | 8 | 2 | 5 | 4.8 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
86275688 | 147775 | 0 | None | -794 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 408 | 2 | 0 | 7 | 3.6 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 | nan | ||
CHEMBL3936869 | 147775 | 0 | None | -794 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 408 | 2 | 0 | 7 | 3.6 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 | nan | ||
18393120 | 5188 | 0 | None | -10 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 502 | 5 | 2 | 4 | 4.0 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL106404 | 5188 | 0 | None | -10 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 502 | 5 | 2 | 4 | 4.0 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
44408736 | 140355 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 471 | 4 | 0 | 1 | 7.3 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Cl | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL382043 | 140355 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 471 | 4 | 0 | 1 | 7.3 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Cl | 10.1016/j.bmcl.2005.11.047 | ||
44314503 | 203285 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 698 | 12 | 1 | 7 | 5.5 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL76704 | 203285 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 698 | 12 | 1 | 7 | 5.5 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL5083565 | 213099 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.1c00793 | ||||
10839138 | 85933 | 0 | None | -11 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 500 | 7 | 0 | 5 | 5.5 | C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 | 10.1021/jm301653f | ||
CHEMBL2313629 | 85933 | 0 | None | -11 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 500 | 7 | 0 | 5 | 5.5 | C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 | 10.1021/jm301653f | ||
51351496 | 60284 | 7 | None | -4 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 410 | 4 | 0 | 5 | 3.7 | COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 | 10.1016/j.bmcl.2011.02.033 | ||
CHEMBL1760205 | 60284 | 7 | None | -4 | 4 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 410 | 4 | 0 | 5 | 3.7 | COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 | 10.1016/j.bmcl.2011.02.033 | ||
86274732 | 122479 | 0 | None | -691 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 388 | 4 | 1 | 8 | 1.8 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3CCO)n1 | nan | ||
CHEMBL3608741 | 122479 | 0 | None | -691 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 388 | 4 | 1 | 8 | 1.8 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3CCO)n1 | nan | ||
86274727 | 160236 | 0 | None | -912 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 392 | 2 | 0 | 7 | 3.1 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 | nan | ||
CHEMBL4114280 | 160236 | 0 | None | -912 | 3 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 392 | 2 | 0 | 7 | 3.1 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 | nan | ||
18546500 | 76354 | 1 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 410 | 5 | 0 | 1 | 7.1 | FC(F)(F)c1cc(COCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL206490 | 76354 | 1 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 410 | 5 | 0 | 1 | 7.1 | FC(F)(F)c1cc(COCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
46228975 | 199947 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 297 | 6 | 3 | 3 | 0.9 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)c1ccccc1 | 10.1021/jm901352b | ||
CHEMBL605906 | 199947 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 297 | 6 | 3 | 3 | 0.9 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)c1ccccc1 | 10.1021/jm901352b | ||
44334665 | 167434 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 583 | 6 | 1 | 5 | 4.0 | O=C1C2CN(C(=O)COCc3ccccc3)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL432007 | 167434 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 583 | 6 | 1 | 5 | 4.0 | O=C1C2CN(C(=O)COCc3ccccc3)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00659-5 | ||
44337308 | 5373 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 600 | 7 | 1 | 4 | 5.6 | O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL107407 | 5373 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 600 | 7 | 1 | 4 | 5.6 | O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL2372065 | 208430 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | None | None | None | CN(C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)N1C2CC3CCC2(CS1(=O)=O)C3(C)C)[C@@H](Cc1ccc(Cc2ccccc2)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(98)00219-4 | ||||
44233184 | 193100 | 0 | None | -12 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 1343 | 32 | 15 | 16 | 1.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL538131 | 193100 | 0 | None | -12 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 1343 | 32 | 15 | 16 | 1.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
44314504 | 102443 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 682 | 12 | 0 | 6 | 6.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL306121 | 102443 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 682 | 12 | 0 | 6 | 6.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44281357 | 111241 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 660 | 10 | 1 | 4 | 9.1 | CO/N=C(\CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL32872 | 111241 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 660 | 10 | 1 | 4 | 9.1 | CO/N=C(\CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL3609618 | 210085 | 0 | None | -1148 | 4 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||||
44334664 | 4472 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 625 | 6 | 0 | 5 | 4.3 | CC(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)COCc1ccccc1 | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL102356 | 4472 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 625 | 6 | 0 | 5 | 4.3 | CC(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)COCc1ccccc1 | 10.1016/s0960-894x(02)00659-5 | ||
86274488 | 160170 | 0 | None | -1584 | 2 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 372 | 3 | 0 | 7 | 2.7 | CCc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1 | nan | ||
CHEMBL4113741 | 160170 | 0 | None | -1584 | 2 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 372 | 3 | 0 | 7 | 2.7 | CCc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1 | nan | ||
44380093 | 120224 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 733 | 13 | 2 | 6 | 7.8 | CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL354892 | 120224 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 733 | 13 | 2 | 6 | 7.8 | CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
10010039 | 39665 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 711 | 14 | 2 | 6 | 8.3 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL147769 | 39665 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 711 | 14 | 2 | 6 | 8.3 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44305793 | 100378 | 0 | None | 5 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 662 | 10 | 2 | 5 | 8.5 | O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
CHEMBL293432 | 100378 | 0 | None | 5 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 662 | 10 | 2 | 5 | 8.5 | O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
44314577 | 159333 | 0 | None | 16 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 782 | 14 | 0 | 8 | 7.1 | CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL41068 | 159333 | 0 | None | 16 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 782 | 14 | 0 | 8 | 7.1 | CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/s0960-894x(00)00464-9 | ||
44314299 | 203435 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 739 | 13 | 1 | 7 | 5.8 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL78070 | 203435 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 739 | 13 | 1 | 7 | 5.8 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44318269 | 204272 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 543 | 3 | 1 | 5 | 4.2 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1ccc3c(c1)OCO3)C2=O | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL84761 | 204272 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 543 | 3 | 1 | 5 | 4.2 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1ccc3c(c1)OCO3)C2=O | 10.1016/s0960-894x(02)00488-2 | ||
44380474 | 58475 | 0 | None | 13 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 678 | 12 | 2 | 5 | 8.2 | CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL168769 | 58475 | 0 | None | 13 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 678 | 12 | 2 | 5 | 8.2 | CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
10417108 | 99638 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL287454 | 99638 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44314482 | 103332 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL309087 | 103332 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44380795 | 204412 | 0 | None | 7 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 734 | 13 | 1 | 7 | 8.3 | COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL85980 | 204412 | 0 | None | 7 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 734 | 13 | 1 | 7 | 8.3 | COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44337313 | 108116 | 0 | None | -7 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 592 | 7 | 1 | 4 | 5.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL320487 | 108116 | 0 | None | -7 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 592 | 7 | 1 | 4 | 5.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
44314482 | 103332 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL309087 | 103332 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44363963 | 120764 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 724 | 13 | 1 | 6 | 7.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL357853 | 120764 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 724 | 13 | 1 | 6 | 7.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
10417108 | 99638 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
CHEMBL287454 | 99638 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
44314482 | 103332 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
CHEMBL309087 | 103332 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
44314482 | 103332 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL309087 | 103332 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
10417108 | 99638 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL287454 | 99638 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44338532 | 7549 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 324 | 6 | 1 | 3 | 3.5 | Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL108822 | 7549 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 324 | 6 | 1 | 3 | 3.5 | Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
9801487 | 205270 | 0 | None | 5 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 406 | 5 | 1 | 3 | 4.8 | Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 | 10.1021/jm058225d | ||
CHEMBL91418 | 205270 | 0 | None | 5 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 406 | 5 | 1 | 3 | 4.8 | Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 | 10.1021/jm058225d | ||
10603383 | 110859 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 582 | 9 | 2 | 3 | 5.6 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1c(Cl)cccc1Cl | 10.1021/jm970499g | ||
CHEMBL326893 | 110859 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 582 | 9 | 2 | 3 | 5.6 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1c(Cl)cccc1Cl | 10.1021/jm970499g | ||
73345476 | 88981 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 800 | 9 | 7 | 8 | 1.0 | CCC(C)Cc1cc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC | 10.1021/jm00029a007 | ||
CHEMBL2370514 | 88981 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 800 | 9 | 7 | 8 | 1.0 | CCC(C)Cc1cc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC | 10.1021/jm00029a007 | ||
45379601 | 199057 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 317 | 7 | 3 | 4 | 0.8 | NC(=O)[C@H](Cc1cccs1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm901352b | ||
CHEMBL600224 | 199057 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 317 | 7 | 3 | 4 | 0.8 | NC(=O)[C@H](Cc1cccs1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm901352b | ||
73212518 | 104121 | 0 | None | 39 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 489 | 8 | 3 | 3 | 4.2 | CNCCNC(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL3104774 | 104121 | 0 | None | 39 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 489 | 8 | 3 | 3 | 4.2 | CNCCNC(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2013.12.033 | ||
73212440 | 104126 | 0 | None | 39 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 558 | 8 | 2 | 4 | 4.2 | CN1CCN(CCNC(=O)[C@@H](NC(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL3104780 | 104126 | 0 | None | 39 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 558 | 8 | 2 | 4 | 4.2 | CN1CCN(CCNC(=O)[C@@H](NC(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/j.bmcl.2013.12.033 | ||
90644624 | 112264 | 0 | None | -6 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 669 | 10 | 3 | 6 | 5.3 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288163 | 112264 | 0 | None | -6 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 669 | 10 | 3 | 6 | 5.3 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3305323 | 112264 | 0 | None | -6 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 669 | 10 | 3 | 6 | 5.3 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
44358385 | 27256 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 702 | 13 | 0 | 6 | 8.4 | COc1cc(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)C(Cc3ccccc3)C2)cc(OC)c1OC | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL136850 | 27256 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 702 | 13 | 0 | 6 | 8.4 | COc1cc(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)C(Cc3ccccc3)C2)cc(OC)c1OC | 10.1016/s0960-894x(02)00956-3 | ||
73212593 | 104123 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 5 | 1 | 3 | 4.7 | CC(C)(C(=O)N[C@@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL3104776 | 104123 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 5 | 1 | 3 | 4.7 | CC(C)(C(=O)N[C@@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
73212592 | 104127 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 545 | 8 | 2 | 4 | 4.3 | CC(C)(C(=O)N[C@@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL3104781 | 104127 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 545 | 8 | 2 | 4 | 4.3 | CC(C)(C(=O)N[C@@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
145948981 | 166930 | 0 | None | -9 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 1139 | 22 | 9 | 9 | 6.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299483 | 166930 | 0 | None | -9 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 1139 | 22 | 9 | 9 | 6.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
73353535 | 90634 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 325 | 7 | 3 | 3 | 1.2 | C[C@@](Cc1ccccc1)(NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
CHEMBL2397485 | 90634 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 325 | 7 | 3 | 3 | 1.2 | C[C@@](Cc1ccccc1)(NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
44281778 | 109208 | 0 | None | -4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 608 | 11 | 1 | 5 | 8.0 | CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL32279 | 109208 | 0 | None | -4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 608 | 11 | 1 | 5 | 8.0 | CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
10794699 | 9147 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 684 | 9 | 2 | 3 | 7.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL110688 | 9147 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 684 | 9 | 2 | 3 | 7.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
10530592 | 10444 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 544 | 10 | 2 | 4 | 4.3 | COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL1169523 | 10444 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 544 | 10 | 2 | 4 | 4.3 | COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
44334591 | 106937 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 667 | 4 | 0 | 5 | 4.9 | CS(=O)(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)c1ccc2ccccc2c1 | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL318093 | 106937 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 667 | 4 | 0 | 5 | 4.9 | CS(=O)(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)c1ccc2ccccc2c1 | 10.1016/s0960-894x(02)00659-5 | ||
10627789 | 100112 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 630 | 18 | 3 | 7 | 5.3 | CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O | 10.1021/jm0205088 | ||
CHEMBL29161 | 100112 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 630 | 18 | 3 | 7 | 5.3 | CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O | 10.1021/jm0205088 | ||
52937271 | 62192 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 515 | 5 | 1 | 3 | 3.8 | CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL1782139 | 62192 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 515 | 5 | 1 | 3 | 3.8 | CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
52937271 | 62192 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 515 | 5 | 1 | 3 | 3.8 | CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm1016285 | ||
CHEMBL1782139 | 62192 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 515 | 5 | 1 | 3 | 3.8 | CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm1016285 | ||
145948797 | 166915 | 0 | None | -26 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 1105 | 22 | 9 | 9 | 5.3 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299390 | 166915 | 0 | None | -26 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 1105 | 22 | 9 | 9 | 5.3 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
10603365 | 9199 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 582 | 9 | 2 | 3 | 5.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1C(F)(F)F | 10.1021/jm970499g | ||
CHEMBL110913 | 9199 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 582 | 9 | 2 | 3 | 5.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1C(F)(F)F | 10.1021/jm970499g | ||
CHEMBL261608 | 208774 | 0 | None | -9 | 3 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 | 10.1021/jm070332f | ||||
44337023 | 108187 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 861 | 11 | 0 | 7 | 8.2 | O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL320770 | 108187 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 861 | 11 | 0 | 7 | 8.2 | O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00645-5 | ||
44462338 | 204082 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 395 | 2 | 1 | 3 | 4.8 | Fc1ccc([C@@H]2NCCOC23CC[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL83156 | 204082 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 395 | 2 | 1 | 3 | 4.8 | Fc1ccc([C@@H]2NCCOC23CC[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
145948847 | 166919 | 0 | None | -28 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1123 | 22 | 9 | 9 | 5.5 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299423 | 166919 | 0 | None | -28 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1123 | 22 | 9 | 9 | 5.5 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
10722607 | 5134 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 624 | 10 | 2 | 3 | 6.6 | CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)C(c1ccccc1)c1ccccc1 | 10.1021/jm970499g | ||
CHEMBL106106 | 5134 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 624 | 10 | 2 | 3 | 6.6 | CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)C(c1ccccc1)c1ccccc1 | 10.1021/jm970499g | ||
10698708 | 109302 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 592 | 9 | 2 | 3 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Br | 10.1021/jm970499g | ||
CHEMBL323274 | 109302 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 592 | 9 | 2 | 3 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Br | 10.1021/jm970499g | ||
10697884 | 163915 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 548 | 9 | 2 | 3 | 5.0 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL421408 | 163915 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 548 | 9 | 2 | 3 | 5.0 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
44408625 | 168157 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 465 | 4 | 0 | 1 | 7.4 | CN(C(=O)c1ccccc1-c1ccccc1)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL436951 | 168157 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 465 | 4 | 0 | 1 | 7.4 | CN(C(=O)c1ccccc1-c1ccccc1)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
44315590 | 167245 | 0 | None | 1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 774 | 14 | 1 | 8 | 7.5 | CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL430609 | 167245 | 0 | None | 1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 774 | 14 | 1 | 8 | 7.5 | CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL2371978 | 208427 | 0 | None | 30 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm061369n | ||||
135413536 | 444 | 80 | None | 50 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
230 | 444 | 80 | None | 50 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.1021/jm2017072 | ||
9918520 | 102278 | 0 | None | 2 | 2 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 753 | 12 | 1 | 7 | 5.8 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL305055 | 102278 | 0 | None | 2 | 2 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 753 | 12 | 1 | 7 | 5.8 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
46889466 | 7197 | 0 | None | 30 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 573 | 8 | 1 | 4 | 7.4 | COCCNc1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1086004 | 7197 | 0 | None | 30 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 573 | 8 | 1 | 4 | 7.4 | COCCNc1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 | 10.1016/j.bmcl.2010.04.008 | ||
104943 | 55099 | 34 | None | 1862 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/s0960-894x(01)00020-8 | ||
CHEMBL16192 | 55099 | 34 | None | 1862 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 5.1 | COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 | 10.1016/s0960-894x(01)00020-8 | ||
44408100 | 140155 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 474 | 6 | 1 | 2 | 6.1 | CC(C)N1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL381524 | 140155 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 474 | 6 | 1 | 2 | 6.1 | CC(C)N1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O | 10.1016/j.bmcl.2005.10.072 | ||
44407972 | 140225 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 653 | 9 | 1 | 6 | 5.7 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL381825 | 140225 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 653 | 9 | 1 | 6 | 5.7 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
44338583 | 5719 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 468 | 6 | 1 | 3 | 5.2 | Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL107875 | 5719 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 468 | 6 | 1 | 3 | 5.2 | Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F | 10.1016/s0960-894x(02)00956-3 | ||
44358280 | 26672 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 446 | 6 | 1 | 3 | 5.2 | Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL136360 | 26672 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 446 | 6 | 1 | 3 | 5.2 | Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
44358334 | 26832 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 364 | 6 | 1 | 3 | 4.2 | Clc1cc(Cl)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL136504 | 26832 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 364 | 6 | 1 | 3 | 4.2 | Clc1cc(Cl)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
44358569 | 116292 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 4.1 | NC(=O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL337789 | 116292 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 4.1 | NC(=O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
44358323 | 118474 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.2 | C[C@H](OC[C@@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL342443 | 118474 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.2 | C[C@H](OC[C@@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
44315573 | 103319 | 0 | None | 1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 707 | 12 | 1 | 7 | 8.3 | CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
CHEMBL308983 | 103319 | 0 | None | 1 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 707 | 12 | 1 | 7 | 8.3 | CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00462-6 | ||
44337371 | 5219 | 0 | None | 4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 720 | 7 | 1 | 4 | 6.8 | O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL106572 | 5219 | 0 | None | 4 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 720 | 7 | 1 | 4 | 6.8 | O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
25129135 | 172028 | 0 | None | -7 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1073 | 27 | 10 | 11 | 2.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 | 10.1021/jm800389v | ||
CHEMBL448998 | 172028 | 0 | None | -7 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1073 | 27 | 10 | 11 | 2.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 | 10.1021/jm800389v | ||
9918479 | 57307 | 0 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 748 | 14 | 1 | 7 | 6.7 | CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL166827 | 57307 | 0 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 748 | 14 | 1 | 7 | 6.7 | CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
22000062 | 76205 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 480 | 4 | 0 | 2 | 7.0 | Cc1ccccc1-c1cnccc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL206268 | 76205 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 480 | 4 | 0 | 2 | 7.0 | Cc1ccccc1-c1cnccc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
145948809 | 166917 | 0 | None | 1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1231 | 22 | 9 | 9 | 5.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299402 | 166917 | 0 | None | 1 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1231 | 22 | 9 | 9 | 5.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
44611294 | 90643 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 329 | 7 | 3 | 3 | 0.9 | NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm400209h | ||
CHEMBL2397494 | 90643 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 329 | 7 | 3 | 3 | 0.9 | NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm400209h | ||
10239000 | 79371 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 488 | 6 | 1 | 3 | 5.3 | C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N(C)C)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
CHEMBL211888 | 79371 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 488 | 6 | 1 | 3 | 5.3 | C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N(C)C)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.031 | ||
11467400 | 6428 | 0 | None | 3 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 587 | 8 | 1 | 4 | 7.2 | CCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 | 10.1016/j.bmcl.2010.04.008 | ||
CHEMBL1082735 | 6428 | 0 | None | 3 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 587 | 8 | 1 | 4 | 7.2 | CCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 | 10.1016/j.bmcl.2010.04.008 | ||
9869764 | 140012 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 480 | 4 | 0 | 2 | 7.0 | Cc1ccccc1-c1ccncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL381058 | 140012 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 480 | 4 | 0 | 2 | 7.0 | Cc1ccccc1-c1ccncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
145948955 | 166926 | 0 | None | 7 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1091 | 22 | 8 | 9 | 5.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299466 | 166926 | 0 | None | 7 | 4 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1091 | 22 | 8 | 9 | 5.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
44409008 | 74766 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 551 | 5 | 0 | 5 | 5.5 | Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL203605 | 74766 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 551 | 5 | 0 | 5 | 5.5 | Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
10530741 | 9103 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 552 | 8 | 2 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1F | 10.1021/jm970499g | ||
CHEMBL110355 | 9103 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 552 | 8 | 2 | 3 | 5.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1F | 10.1021/jm970499g | ||
10115747 | 140625 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 464 | 5 | 1 | 2 | 5.5 | C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL382771 | 140625 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 464 | 5 | 1 | 2 | 5.5 | C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL2419540 | 208696 | 0 | None | -4 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
46227360 | 200895 | 0 | None | 1 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL611924 | 200895 | 0 | None | 1 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
44138555 | 192569 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
CHEMBL523156 | 192569 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
44408766 | 96476 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 452 | 4 | 0 | 2 | 6.4 | Cc1ccccc1-c1cccnc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL265986 | 96476 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 452 | 4 | 0 | 2 | 6.4 | Cc1ccccc1-c1cccnc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
10507650 | 162778 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 591 | 9 | 3 | 4 | 4.6 | CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL419004 | 162778 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 591 | 9 | 3 | 4 | 4.6 | CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
90644635 | 112209 | 0 | None | 6 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 711 | 12 | 2 | 6 | 5.9 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288170 | 112209 | 0 | None | 6 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 711 | 12 | 2 | 6 | 5.9 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3304460 | 112209 | 0 | None | 6 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 711 | 12 | 2 | 6 | 5.9 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
44408033 | 74423 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 540 | 6 | 1 | 4 | 5.6 | CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL203111 | 74423 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 540 | 6 | 1 | 4 | 5.6 | CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 | 10.1016/j.bmcl.2005.10.077 | ||
44337414 | 9125 | 0 | None | 5 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 889 | 13 | 2 | 7 | 9.1 | O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL110507 | 9125 | 0 | None | 5 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 889 | 13 | 2 | 7 | 9.1 | O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00645-5 | ||
46227362 | 200897 | 0 | None | -301 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL611926 | 200897 | 0 | None | -301 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
44314154 | 203358 | 0 | None | 24 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 585 | 10 | 1 | 5 | 6.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL77265 | 203358 | 0 | None | 24 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 585 | 10 | 1 | 5 | 6.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44334845 | 108420 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 725 | 6 | 0 | 7 | 5.2 | COc1ccc(OC)c(S(=O)(=O)N2CCC3(CC2)C2C(=O)N(c4ccccc4)C(=O)C2CN3C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL321098 | 108420 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 725 | 6 | 0 | 7 | 5.2 | COc1ccc(OC)c(S(=O)(=O)N2CCC3(CC2)C2C(=O)N(c4ccccc4)C(=O)C2CN3C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 | 10.1016/s0960-894x(02)00659-5 | ||
3668 | 1531 | 36 | None | -38 | 10 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm901352b | ||||
5311081 | 1531 | 36 | None | -38 | 10 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm901352b | ||||
CHEMBL333357 | 1531 | 36 | None | -38 | 10 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm901352b | ||||
CHEMBL589982 | 1531 | 36 | None | -38 | 10 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm901352b | ||||
44334666 | 4559 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 736 | 4 | 1 | 7 | 4.5 | O=C1COc2ccc(S(=O)(=O)N3CCC4(CC3)C3C(=O)N(c5ccccc5)C(=O)C3CN4C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2N1 | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL102917 | 4559 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 736 | 4 | 1 | 7 | 4.5 | O=C1COc2ccc(S(=O)(=O)N3CCC4(CC3)C3C(=O)N(c5ccccc5)C(=O)C3CN4C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2N1 | 10.1016/s0960-894x(02)00659-5 | ||
90663661 | 106229 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1140 | 33 | 10 | 15 | -0.0 | CCCN1C(=O)C2NC(c3ccc(OCC(=O)NCCNC(=O)C(N)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)cc3)=NC2N(CCC)C1=O | 10.1021/jm00391a046 | ||
CHEMBL3143946 | 106229 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1140 | 33 | 10 | 15 | -0.0 | CCCN1C(=O)C2NC(c3ccc(OCC(=O)NCCNC(=O)C(N)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)cc3)=NC2N(CCC)C1=O | 10.1021/jm00391a046 | ||
118730935 | 117656 | 0 | None | -10715 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 699 | 15 | 6 | 7 | 1.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408521 | 117656 | 0 | None | -10715 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 699 | 15 | 6 | 7 | 1.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
44334708 | 4565 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 609 | 2 | 0 | 4 | 5.4 | CC(C)(C)C(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL102932 | 4565 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 609 | 2 | 0 | 4 | 5.4 | CC(C)(C)C(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00659-5 | ||
118731117 | 117670 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 740 | 17 | 7 | 7 | 2.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2ccccc2)CC(C)C)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408734 | 117670 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 740 | 17 | 7 | 7 | 2.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2ccccc2)CC(C)C)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
56682292 | 65579 | 0 | None | 12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 808 | 15 | 2 | 6 | 7.7 | O=C(COCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.08.027 | ||
CHEMBL1835845 | 65579 | 0 | None | 12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 808 | 15 | 2 | 6 | 7.7 | O=C(COCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.08.027 | ||
90644631 | 111453 | 0 | None | -12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 684 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288167 | 111453 | 0 | None | -12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 684 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
44358248 | 26468 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 484 | 8 | 1 | 3 | 6.2 | C=Cc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1C=C | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL136187 | 26468 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 484 | 8 | 1 | 3 | 6.2 | C=Cc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1C=C | 10.1016/s0960-894x(02)00956-3 | ||
20599018 | 197722 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 517 | 2 | 1 | 2 | 6.5 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
CHEMBL591075 | 197722 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 517 | 2 | 1 | 2 | 6.5 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
44304398 | 102213 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 459 | 2 | 1 | 2 | 5.3 | CC1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)00353-3 | ||
CHEMBL304638 | 102213 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 459 | 2 | 1 | 2 | 5.3 | CC1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)00353-3 | ||
16655023 | 106955 | 1 | None | -251 | 7 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 481 | 7 | 0 | 7 | 3.7 | COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 | 10.1016/j.bmc.2007.03.053 | ||
CHEMBL318235 | 106955 | 1 | None | -251 | 7 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 481 | 7 | 0 | 7 | 3.7 | COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 | 10.1016/j.bmc.2007.03.053 | ||
44408911 | 140033 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 355 | 4 | 1 | 3 | 5.8 | Cc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL381179 | 140033 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 355 | 4 | 1 | 3 | 5.8 | Cc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl | 10.1016/j.bmcl.2005.11.047 | ||
73212517 | 104122 | 0 | None | 31 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 475 | 7 | 3 | 3 | 3.9 | CC(C)(C(=O)N[C@H](C(=O)NCCN)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL3104775 | 104122 | 0 | None | 31 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 475 | 7 | 3 | 3 | 3.9 | CC(C)(C(=O)N[C@H](C(=O)NCCN)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
73212516 | 104124 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 502 | 5 | 1 | 3 | 4.7 | CC(C)(C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL3104777 | 104124 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 502 | 5 | 1 | 3 | 4.7 | CC(C)(C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.12.033 | ||
90644626 | 112256 | 0 | None | 2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.7 | CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288164 | 112256 | 0 | None | 2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.7 | CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3305163 | 112256 | 0 | None | 2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.7 | CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
44304340 | 201182 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 503 | 3 | 1 | 4 | 4.4 | COC(=O)C1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)00353-3 | ||
CHEMBL62597 | 201182 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 503 | 3 | 1 | 4 | 4.4 | COC(=O)C1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)00353-3 | ||
44337270 | 108115 | 0 | None | -4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 665 | 8 | 3 | 6 | 4.5 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL320486 | 108115 | 0 | None | -4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 665 | 8 | 3 | 6 | 4.5 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
44337007 | 109919 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 863 | 9 | 2 | 7 | 8.5 | O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL324416 | 109919 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 863 | 9 | 2 | 7 | 8.5 | O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00645-5 | ||
52937273 | 62190 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 458 | 3 | 0 | 2 | 4.7 | CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1016285 | ||
CHEMBL1782137 | 62190 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 458 | 3 | 0 | 2 | 4.7 | CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm1016285 | ||
44281572 | 109903 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 705 | 10 | 2 | 6 | 8.7 | CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL32431 | 109903 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 705 | 10 | 2 | 6 | 8.7 | CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44281776 | 113753 | 0 | None | -3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 568 | 11 | 1 | 5 | 7.3 | CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL33302 | 113753 | 0 | None | -3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 568 | 11 | 1 | 5 | 7.3 | CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
54581461 | 60934 | 0 | None | -2089 | 4 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1143 | 29 | 10 | 12 | 4.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 | 10.1021/jm101023r | ||
CHEMBL1766207 | 60934 | 0 | None | -2089 | 4 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1143 | 29 | 10 | 12 | 4.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 | 10.1021/jm101023r | ||
86275687 | 143109 | 0 | None | -776 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 374 | 2 | 0 | 7 | 3.0 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)cc2)C3C)n1 | nan | ||
CHEMBL3899877 | 143109 | 0 | None | -776 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 374 | 2 | 0 | 7 | 3.0 | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)cc2)C3C)n1 | nan | ||
10007108 | 163413 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 527 | 2 | 1 | 3 | 5.4 | Cc1cc(C)c(C(=O)N2CCC3(CC2)NC(=O)N(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c(C)c1 | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL420787 | 163413 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 527 | 2 | 1 | 3 | 5.4 | Cc1cc(C)c(C(=O)N2CCC3(CC2)NC(=O)N(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c(C)c1 | 10.1016/s0960-894x(02)00488-2 | ||
44380475 | 58476 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 675 | 11 | 1 | 4 | 9.2 | CO/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL168770 | 58476 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 675 | 11 | 1 | 4 | 9.2 | CO/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44314476 | 104603 | 0 | None | 12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
CHEMBL311387 | 104603 | 0 | None | 12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 676 | 11 | 1 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
24768355 | 168329 | 0 | None | -53 | 5 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1077 | 22 | 9 | 9 | 4.7 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL438389 | 168329 | 0 | None | -53 | 5 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1077 | 22 | 9 | 9 | 4.7 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
24768355 | 168329 | 0 | None | -53 | 5 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1077 | 22 | 9 | 9 | 4.7 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm070332f | ||
CHEMBL438389 | 168329 | 0 | None | -53 | 5 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1077 | 22 | 9 | 9 | 4.7 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm070332f | ||
44281713 | 99202 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 600 | 13 | 1 | 7 | 6.7 | CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL284396 | 99202 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 600 | 13 | 1 | 7 | 6.7 | CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44281788 | 99524 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 583 | 11 | 2 | 6 | 5.9 | CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL286640 | 99524 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 583 | 11 | 2 | 6 | 5.9 | CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
73353536 | 90636 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 337 | 6 | 3 | 3 | 1.3 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1NCC[C@H]1c1ccccc1 | 10.1021/jm400209h | ||
CHEMBL2397487 | 90636 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 337 | 6 | 3 | 3 | 1.3 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1NCC[C@H]1c1ccccc1 | 10.1021/jm400209h | ||
2110 | 2922 | 33 | None | -1258 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1016/j.bmcl.2011.02.033 | ||
219077 | 2922 | 33 | None | -1258 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1016/j.bmcl.2011.02.033 | ||
3480 | 2922 | 33 | None | -1258 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1016/j.bmcl.2011.02.033 | ||
CHEMBL346178 | 2922 | 33 | None | -1258 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1016/j.bmcl.2011.02.033 | ||
DB04872 | 2922 | 33 | None | -1258 | 6 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1016/j.bmcl.2011.02.033 | ||
10600014 | 167307 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 459 | 7 | 2 | 3 | 4.9 | COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)NC(c1ccccc1)c1ccccc1 | 10.1021/jm970499g | ||
CHEMBL431070 | 167307 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 459 | 7 | 2 | 3 | 4.9 | COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)NC(c1ccccc1)c1ccccc1 | 10.1021/jm970499g | ||
10007326 | 106383 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 535 | 2 | 1 | 3 | 5.6 | O=C(c1cccc2ccccc12)N1CCC2(CC1)NC(=O)N(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2=O | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL314499 | 106383 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 535 | 2 | 1 | 3 | 5.6 | O=C(c1cccc2ccccc12)N1CCC2(CC1)NC(=O)N(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2=O | 10.1016/s0960-894x(02)00488-2 | ||
44314481 | 203228 | 0 | None | 10 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 662 | 10 | 2 | 5 | 8.5 | O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
CHEMBL76334 | 203228 | 0 | None | 10 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 662 | 10 | 2 | 5 | 8.5 | O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
145948839 | 166918 | 0 | None | -85 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1137 | 22 | 8 | 9 | 5.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299415 | 166918 | 0 | None | -85 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1137 | 22 | 8 | 9 | 5.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
145948968 | 166928 | 0 | None | -8 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1095 | 22 | 9 | 9 | 4.8 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299479 | 166928 | 0 | None | -8 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1095 | 22 | 9 | 9 | 4.8 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
45271306 | 193999 | 0 | None | -645 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1438 | 33 | 14 | 16 | 3.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL556537 | 193999 | 0 | None | -645 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1438 | 33 | 14 | 16 | 3.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
118730934 | 117655 | 0 | None | -363 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 835 | 15 | 6 | 7 | 4.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408520 | 117655 | 0 | None | -363 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 835 | 15 | 6 | 7 | 4.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
51003494 | 58014 | 0 | None | -44 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 556 | 8 | 0 | 4 | 3.5 | CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 | 10.1016/j.bmcl.2010.12.135 | ||
CHEMBL1682680 | 58014 | 0 | None | -44 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 556 | 8 | 0 | 4 | 3.5 | CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 | 10.1016/j.bmcl.2010.12.135 | ||
44337355 | 5274 | 0 | None | -26 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 581 | 7 | 2 | 4 | 5.2 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL106877 | 5274 | 0 | None | -26 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 581 | 7 | 2 | 4 | 5.2 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
118731114 | 117667 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 862 | 16 | 7 | 7 | 4.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408731 | 117667 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 862 | 16 | 7 | 7 | 4.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
44363948 | 36148 | 0 | None | 5 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 653 | 11 | 0 | 5 | 8.3 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL144668 | 36148 | 0 | None | 5 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 653 | 11 | 0 | 5 | 8.3 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44363912 | 118252 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 681 | 12 | 0 | 5 | 8.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL341843 | 118252 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 681 | 12 | 0 | 5 | 8.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
10507772 | 109265 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 598 | 9 | 2 | 3 | 6.1 | CN(Cc1ccc2ccccc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL323044 | 109265 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 598 | 9 | 2 | 3 | 6.1 | CN(Cc1ccc2ccccc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
44336987 | 108462 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 791 | 11 | 0 | 5 | 9.2 | O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL321154 | 108462 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 791 | 11 | 0 | 5 | 9.2 | O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 | 10.1016/s0960-894x(02)00645-5 | ||
9809308 | 204011 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 624 | 6 | 0 | 4 | 5.4 | CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)CN3CCC(Cc4ccccc4)CC3)CC2)C1=O | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL82552 | 204011 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 624 | 6 | 0 | 4 | 5.4 | CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)CN3CCC(Cc4ccccc4)CC3)CC2)C1=O | 10.1016/s0960-894x(02)00488-2 | ||
4189 | 205195 | 91 | None | -27 | 34 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
CHEMBL1559 | 205195 | 91 | None | -27 | 34 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
CHEMBL91 | 205195 | 91 | None | -27 | 34 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
44408628 | 139833 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 409 | 5 | 1 | 1 | 6.7 | FC(F)(F)c1cc(CNCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL380827 | 139833 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 409 | 5 | 1 | 1 | 6.7 | FC(F)(F)c1cc(CNCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
44380764 | 120216 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 689 | 11 | 1 | 5 | 8.6 | CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL354822 | 120216 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 689 | 11 | 1 | 5 | 8.6 | CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44363978 | 40249 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 697 | 12 | 1 | 6 | 7.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL148282 | 40249 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 697 | 12 | 1 | 6 | 7.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
11801041 | 109965 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 562 | 9 | 1 | 3 | 5.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL324667 | 109965 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 562 | 9 | 1 | 3 | 5.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
44334654 | 107715 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 653 | 3 | 0 | 5 | 4.8 | CN1C(=O)C2CN(S(=O)(=O)c3ccc4ccccc4c3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL319653 | 107715 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 653 | 3 | 0 | 5 | 4.8 | CN1C(=O)C2CN(S(=O)(=O)c3ccc4ccccc4c3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O | 10.1016/s0960-894x(02)00659-5 | ||
52937270 | 62191 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 501 | 5 | 2 | 3 | 3.4 | CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm1016285 | ||
CHEMBL1782138 | 62191 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 501 | 5 | 2 | 3 | 3.4 | CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/jm1016285 | ||
145948809 | 166917 | 0 | None | -11 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1231 | 22 | 9 | 9 | 5.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299402 | 166917 | 0 | None | -11 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1231 | 22 | 9 | 9 | 5.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
44314945 | 203287 | 0 | None | 9 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 728 | 17 | 1 | 7 | 6.9 | CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL76727 | 203287 | 0 | None | 9 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 728 | 17 | 1 | 7 | 6.9 | CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 | 10.1016/s0960-894x(00)00464-9 | ||
44281392 | 99496 | 0 | None | 3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 690 | 12 | 1 | 5 | 8.8 | CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL286433 | 99496 | 0 | None | 3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 690 | 12 | 1 | 5 | 8.8 | CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44323563 | 205286 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 322 | 4 | 2 | 3 | 3.4 | COc1ccccc1CN[C@H]1CCCN[C@]12CCc1ccccc12 | 10.1016/0960-894X(95)00481-8 | ||
CHEMBL91475 | 205286 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 322 | 4 | 2 | 3 | 3.4 | COc1ccccc1CN[C@H]1CCCN[C@]12CCc1ccccc12 | 10.1016/0960-894X(95)00481-8 | ||
90644629 | 111168 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 711 | 12 | 2 | 6 | 5.8 | CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 | 10.1021/ml400528y | ||
CHEMBL3286415 | 111168 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 711 | 12 | 2 | 6 | 5.8 | CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 | 10.1021/ml400528y | ||
10300825 | 29729 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 504 | 8 | 0 | 5 | 4.8 | COC(=O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL138839 | 29729 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 504 | 8 | 0 | 5 | 4.8 | COC(=O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
44304301 | 201626 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 445 | 2 | 1 | 2 | 5.8 | CC1c2ccccc2NCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)00353-3 | ||
CHEMBL64839 | 201626 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 445 | 2 | 1 | 2 | 5.8 | CC1c2ccccc2NCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/S0960-894X(97)00353-3 | ||
90644616 | 112239 | 0 | None | 25 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288159 | 112239 | 0 | None | 25 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3304856 | 112239 | 0 | None | 25 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
90644610 | 112252 | 0 | None | 15 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 697 | 12 | 2 | 6 | 5.7 | CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288156 | 112252 | 0 | None | 15 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 697 | 12 | 2 | 6 | 5.7 | CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3305158 | 112252 | 0 | None | 15 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 697 | 12 | 2 | 6 | 5.7 | CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
2110 | 2922 | 33 | None | -1258 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm5017413 | ||
219077 | 2922 | 33 | None | -1258 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm5017413 | ||
3480 | 2922 | 33 | None | -1258 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm5017413 | ||
CHEMBL346178 | 2922 | 33 | None | -1258 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm5017413 | ||
DB04872 | 2922 | 33 | None | -1258 | 6 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 10.1021/jm5017413 | ||
44338557 | 9258 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 330 | 6 | 1 | 3 | 3.5 | Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL111244 | 9258 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 330 | 6 | 1 | 3 | 3.5 | Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
44363926 | 38833 | 0 | None | 3 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 669 | 11 | 1 | 6 | 7.3 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL146882 | 38833 | 0 | None | 3 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 669 | 11 | 1 | 6 | 7.3 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44314867 | 156785 | 0 | None | 8 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 705 | 13 | 3 | 5 | 7.1 | NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
CHEMBL407749 | 156785 | 0 | None | 8 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 705 | 13 | 3 | 5 | 7.1 | NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
44408755 | 74688 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 4 | 0 | 2 | 7.0 | Cc1ccccc1-c1cccnc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL203481 | 74688 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 4 | 0 | 2 | 7.0 | Cc1ccccc1-c1cccnc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
10032693 | 109274 | 0 | None | 2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 703 | 10 | 1 | 5 | 8.3 | CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL32309 | 109274 | 0 | None | 2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 703 | 10 | 1 | 5 | 8.3 | CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
107686 | 3327 | 37 | None | 15 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80650-2 | ||
3522 | 3327 | 37 | None | 15 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80650-2 | ||
CHEMBL131171 | 3327 | 37 | None | 15 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 5 | 1 | 3 | 5.1 | COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80650-2 | ||
9939040 | 4941 | 5 | None | 2 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 623 | 7 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1021/jm030786m | ||
CHEMBL105060 | 4941 | 5 | None | 2 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 623 | 7 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1021/jm030786m | ||
CHEMBL2419544 | 208700 | 0 | None | -14 | 3 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
10602943 | 106934 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 559 | 8 | 2 | 4 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 | 10.1021/jm970499g | ||
CHEMBL318084 | 106934 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 559 | 8 | 2 | 4 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 | 10.1021/jm970499g | ||
9824321 | 75091 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 436 | 5 | 2 | 2 | 4.6 | O=C1NCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL204206 | 75091 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 436 | 5 | 2 | 2 | 4.6 | O=C1NCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 | 10.1016/j.bmcl.2005.10.072 | ||
9846661 | 76222 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 452 | 4 | 0 | 2 | 6.4 | Cc1ccccc1-c1cnccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL206294 | 76222 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 452 | 4 | 0 | 2 | 6.4 | Cc1ccccc1-c1cnccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
44380457 | 57808 | 0 | None | 3 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 698 | 12 | 0 | 7 | 6.6 | COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL167613 | 57808 | 0 | None | 3 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 698 | 12 | 0 | 7 | 6.6 | COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
9939307 | 201793 | 0 | None | -2 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 640 | 10 | 0 | 5 | 7.0 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL66106 | 201793 | 0 | None | -2 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 640 | 10 | 0 | 5 | 7.0 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
10531666 | 9101 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 601 | 9 | 2 | 4 | 5.5 | CN(Cc1ccccc1)C(=O)[C@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL110340 | 9101 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 601 | 9 | 2 | 4 | 5.5 | CN(Cc1ccccc1)C(=O)[C@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL3609615 | 210082 | 0 | None | -24 | 4 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | None | None | None | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||||
44318312 | 104387 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 395 | 2 | 1 | 3 | 4.8 | Fc1ccc([C@@H]2NCCOC23CC[C@H](c2ccccc2C(F)(F)F)CO3)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
CHEMBL311027 | 104387 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 395 | 2 | 1 | 3 | 4.8 | Fc1ccc([C@@H]2NCCOC23CC[C@H](c2ccccc2C(F)(F)F)CO3)cc1 | 10.1016/s0960-894x(02)00506-1 | ||
86275451 | 159546 | 0 | None | -5623 | 3 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 420 | 4 | 0 | 8 | 3.8 | CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 | nan | ||
CHEMBL4108623 | 159546 | 0 | None | -5623 | 3 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 420 | 4 | 0 | 8 | 3.8 | CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 | nan | ||
57396389 | 68026 | 0 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 734 | 14 | 4 | 6 | 6.4 | CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.ejmech.2011.08.042 | ||
CHEMBL1916636 | 68026 | 0 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 734 | 14 | 4 | 6 | 6.4 | CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.ejmech.2011.08.042 | ||
44407890 | 74824 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 432 | 5 | 2 | 2 | 5.0 | C[C@@H](OC[C@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL203655 | 74824 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 432 | 5 | 2 | 2 | 5.0 | C[C@@H](OC[C@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
44337208 | 5168 | 0 | None | -38 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 635 | 7 | 2 | 5 | 4.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL106300 | 5168 | 0 | None | -38 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 635 | 7 | 2 | 5 | 4.9 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
44282003 | 99649 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 689 | 11 | 1 | 5 | 8.6 | CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL287523 | 99649 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 689 | 11 | 1 | 5 | 8.6 | CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44334500 | 4468 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 599 | 5 | 1 | 6 | 4.1 | COc1ccc(C(=O)N2CC3C(=O)N(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)C(=O)C3C23CCNCC3)cc1OC | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL102332 | 4468 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 599 | 5 | 1 | 6 | 4.1 | COc1ccc(C(=O)N2CC3C(=O)N(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)C(=O)C3C23CCNCC3)cc1OC | 10.1016/s0960-894x(02)00659-5 | ||
44281744 | 112975 | 0 | None | -1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 739 | 11 | 1 | 6 | 7.8 | CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL33194 | 112975 | 0 | None | -1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 739 | 11 | 1 | 6 | 7.8 | CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44363877 | 38913 | 0 | None | 3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 709 | 12 | 1 | 5 | 8.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL146947 | 38913 | 0 | None | 3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 709 | 12 | 1 | 5 | 8.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44409004 | 74090 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 515 | 4 | 0 | 1 | 7.4 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Br | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL202720 | 74090 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 515 | 4 | 0 | 1 | 7.4 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Br | 10.1016/j.bmcl.2005.11.047 | ||
46227361 | 200896 | 0 | None | -85 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL611925 | 200896 | 0 | None | -85 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
44318565 | 204213 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 528 | 3 | 2 | 3 | 5.2 | Cc1cccc(NC(=O)N2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL84161 | 204213 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 528 | 3 | 2 | 3 | 5.2 | Cc1cccc(NC(=O)N2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL2372339 | 208477 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O | 10.1021/jm00391a046 | ||||
44318497 | 204282 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 563 | 3 | 0 | 3 | 5.9 | CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3cccc4ccccc34)CC2)C1=O | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL84873 | 204282 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 563 | 3 | 0 | 3 | 5.9 | CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3cccc4ccccc34)CC2)C1=O | 10.1016/s0960-894x(02)00488-2 | ||
145948965 | 166927 | 0 | None | -18 | 4 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1183 | 22 | 9 | 9 | 6.1 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299476 | 166927 | 0 | None | -18 | 4 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1183 | 22 | 9 | 9 | 6.1 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
44314872 | 96424 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 740 | 13 | 1 | 7 | 6.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL265499 | 96424 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 740 | 13 | 1 | 7 | 6.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44337202 | 7893 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 700 | 7 | 1 | 4 | 7.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL109053 | 7893 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 700 | 7 | 1 | 4 | 7.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
44337079 | 106712 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 877 | 11 | 2 | 7 | 7.5 | CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccccc2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL316553 | 106712 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 877 | 11 | 2 | 7 | 7.5 | CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccccc2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 | 10.1016/s0960-894x(02)00645-5 | ||
44337024 | 108189 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 793 | 11 | 0 | 7 | 6.9 | O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL320771 | 108189 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 793 | 11 | 0 | 7 | 6.9 | O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 | 10.1016/s0960-894x(02)00645-5 | ||
145948744 | 166914 | 0 | None | -47 | 4 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1120 | 22 | 8 | 9 | 5.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299371 | 166914 | 0 | None | -47 | 4 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1120 | 22 | 8 | 9 | 5.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
10769914 | 110662 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 601 | 10 | 3 | 3 | 5.5 | CN(CCc1c[nH]c2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL326429 | 110662 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 601 | 10 | 3 | 3 | 5.5 | CN(CCc1c[nH]c2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL2112592 | 207496 | 0 | None | -1 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | None | None | None | CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O | 10.1021/jm00029a007 | ||||
44380596 | 59040 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 706 | 13 | 1 | 6 | 8.7 | COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL170727 | 59040 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 706 | 13 | 1 | 6 | 8.7 | COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44408726 | 76207 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 419 | 4 | 1 | 3 | 6.3 | Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1Br | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL206274 | 76207 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 419 | 4 | 1 | 3 | 6.3 | Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1Br | 10.1016/j.bmcl.2005.11.047 | ||
10091563 | 39472 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 386 | 7 | 2 | 3 | 4.7 | COc1ccccc1CN[C@H]1CCCN[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00104a018 | ||
CHEMBL147543 | 39472 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 386 | 7 | 2 | 3 | 4.7 | COc1ccccc1CN[C@H]1CCCN[C@H]1C(c1ccccc1)c1ccccc1 | 10.1021/jm00104a018 | ||
44314861 | 167217 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 705 | 13 | 3 | 5 | 7.1 | NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
CHEMBL430416 | 167217 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 705 | 13 | 3 | 5 | 7.1 | NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
11801965 | 5149 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 616 | 9 | 2 | 3 | 6.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL106217 | 5149 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 616 | 9 | 2 | 3 | 6.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
10603279 | 7940 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 577 | 9 | 3 | 4 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C(N)=O)c1 | 10.1021/jm970499g | ||
CHEMBL109080 | 7940 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 577 | 9 | 3 | 4 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C(N)=O)c1 | 10.1021/jm970499g | ||
9939307 | 201793 | 0 | None | -3 | 4 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 640 | 10 | 0 | 5 | 7.0 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
CHEMBL66106 | 201793 | 0 | None | -3 | 4 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 640 | 10 | 0 | 5 | 7.0 | CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00340-2 | ||
44282001 | 99347 | 0 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 705 | 12 | 1 | 7 | 7.0 | CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL285422 | 99347 | 0 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 705 | 12 | 1 | 7 | 7.0 | CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44281571 | 109900 | 0 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 718 | 10 | 2 | 5 | 8.7 | CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL32430 | 109900 | 0 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 718 | 10 | 2 | 5 | 8.7 | CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44281976 | 110085 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 627 | 12 | 1 | 7 | 6.2 | CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL32537 | 110085 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 627 | 12 | 1 | 7 | 6.2 | CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
10321715 | 26500 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 452 | 6 | 1 | 3 | 4.4 | Brc1cc(Br)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL136213 | 26500 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 452 | 6 | 1 | 3 | 4.4 | Brc1cc(Br)cc(COCC(c2ccccc2)N2CCNCC2)c1 | 10.1016/s0960-894x(02)00956-3 | ||
44338618 | 108838 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 5.0 | Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL321892 | 108838 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 5.0 | Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 | 10.1016/s0960-894x(02)00956-3 | ||
10393853 | 109224 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 603 | 3 | 0 | 5 | 3.8 | CS(=O)(=O)N1CC2C(=O)N(c3ccccc3)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL322885 | 109224 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 603 | 3 | 0 | 5 | 3.8 | CS(=O)(=O)N1CC2C(=O)N(c3ccccc3)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 | 10.1016/s0960-894x(02)00659-5 | ||
2755911 | 75088 | 48 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 298 | 6 | 2 | 3 | 2.0 | NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1021/ml5002954 | ||
CHEMBL2042018 | 75088 | 48 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 298 | 6 | 2 | 3 | 2.0 | NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1021/ml5002954 | ||
2755911 | 75088 | 48 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 298 | 6 | 2 | 3 | 2.0 | NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1021/ml5002954 | ||
CHEMBL2042018 | 75088 | 48 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 298 | 6 | 2 | 3 | 2.0 | NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1021/ml5002954 | ||
2755911 | 75088 | 48 | None | -1 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 298 | 6 | 2 | 3 | 2.0 | NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1016/j.bmcl.2018.06.009 | ||
CHEMBL2042018 | 75088 | 48 | None | -1 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 298 | 6 | 2 | 3 | 2.0 | NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 | 10.1016/j.bmcl.2018.06.009 | ||
15887537 | 108559 | 0 | None | 3 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 700 | 7 | 1 | 4 | 7.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL321270 | 108559 | 0 | None | 3 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 700 | 7 | 1 | 4 | 7.3 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
145948968 | 166928 | 0 | None | -1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1095 | 22 | 9 | 9 | 4.8 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299479 | 166928 | 0 | None | -1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1095 | 22 | 9 | 9 | 4.8 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
44364030 | 36417 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 711 | 13 | 1 | 6 | 8.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL144887 | 36417 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 711 | 13 | 1 | 6 | 8.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44282004 | 121247 | 0 | None | 2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 675 | 11 | 2 | 5 | 8.3 | CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL35891 | 121247 | 0 | None | 2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 675 | 11 | 2 | 5 | 8.3 | CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
90644608 | 112210 | 0 | None | 79 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 697 | 12 | 2 | 6 | 5.7 | CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288155 | 112210 | 0 | None | 79 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 697 | 12 | 2 | 6 | 5.7 | CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3304468 | 112210 | 0 | None | 79 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 697 | 12 | 2 | 6 | 5.7 | CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
44338652 | 108123 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 4.9 | COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL320544 | 108123 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 4.9 | COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 | 10.1016/s0960-894x(02)00956-3 | ||
46224897 | 197433 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 475 | 3 | 1 | 2 | 5.1 | Cc1cc(F)ccc1C1CNCC2CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)N21 | 10.1016/j.bmcl.2009.11.078 | ||
CHEMBL589130 | 197433 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 475 | 3 | 1 | 2 | 5.1 | Cc1cc(F)ccc1C1CNCC2CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)N21 | 10.1016/j.bmcl.2009.11.078 | ||
73350555 | 90637 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 337 | 6 | 3 | 3 | 1.3 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1NCC[C@@H]1c1ccccc1 | 10.1021/jm400209h | ||
CHEMBL2397488 | 90637 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 337 | 6 | 3 | 3 | 1.3 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1NCC[C@@H]1c1ccccc1 | 10.1021/jm400209h | ||
2098 | 3638 | 31 | None | -2 | 6 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00073a022 | ||||
36511 | 3638 | 31 | None | -2 | 6 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00073a022 | ||||
3805 | 3638 | 31 | None | -2 | 6 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00073a022 | ||||
3835 | 3638 | 31 | None | -2 | 6 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00073a022 | ||||
CHEMBL235363 | 3638 | 31 | None | -2 | 6 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00073a022 | ||||
44334581 | 5162 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 629 | 3 | 1 | 5 | 6.0 | O=C1C2CN(C(=O)c3sc4ccccc4c3Cl)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL106273 | 5162 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 629 | 3 | 1 | 5 | 6.0 | O=C1C2CN(C(=O)c3sc4ccccc4c3Cl)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00659-5 | ||
2090 | 2726 | 20 | None | -309 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm5017413 | ||||
5311312 | 2726 | 20 | None | -309 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm5017413 | ||||
CHEMBL437797 | 2726 | 20 | None | -309 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm5017413 | ||||
445694 | 119524 | 75 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 164 | 3 | 2 | 2 | 0.0 | NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm901352b | ||
CHEMBL350320 | 119524 | 75 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 164 | 3 | 2 | 2 | 0.0 | NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm901352b | ||
11305162 | 74421 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 4 | 0 | 1 | 6.7 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL203109 | 74421 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 4 | 0 | 1 | 6.7 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2005.11.047 | ||
44334489 | 106814 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 559 | 3 | 0 | 5 | 4.5 | CN1C(=O)C2CN(Cc3cccs3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL317209 | 106814 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 559 | 3 | 0 | 5 | 4.5 | CN1C(=O)C2CN(Cc3cccs3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O | 10.1016/s0960-894x(02)00659-5 | ||
44337354 | 5384 | 0 | None | -58 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 656 | 8 | 2 | 7 | 5.3 | CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL107469 | 5384 | 0 | None | -58 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 656 | 8 | 2 | 7 | 5.3 | CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 | 10.1016/s0960-894x(02)00645-5 | ||
44314834 | 203439 | 0 | None | 2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 667 | 11 | 0 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL78092 | 203439 | 0 | None | 2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 667 | 11 | 0 | 5 | 8.7 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44281771 | 99179 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 630 | 14 | 1 | 8 | 6.7 | CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL284269 | 99179 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 630 | 14 | 1 | 8 | 6.7 | CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
7088460 | 197600 | 1 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm901352b | ||
CHEMBL590275 | 197600 | 1 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm901352b | ||
70689371 | 77976 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1372 | 34 | 14 | 16 | -1.0 | CC(C)C[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)N1CC[C@@]2(CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)C2CCCN2)C1=O | 10.1016/s0960-894x(98)00219-4 | ||
CHEMBL2110361 | 77976 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1372 | 34 | 14 | 16 | -1.0 | CC(C)C[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)N1CC[C@@]2(CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)C2CCCN2)C1=O | 10.1016/s0960-894x(98)00219-4 | ||
46227360 | 200895 | 0 | None | -151 | 4 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL611924 | 200895 | 0 | None | -151 | 4 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1210 | 18 | 10 | 12 | 4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
18546495 | 140182 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 437 | 4 | 0 | 1 | 6.6 | CN(C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL381744 | 140182 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 437 | 4 | 0 | 1 | 6.6 | CN(C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2005.11.047 | ||
44380680 | 57283 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 673 | 11 | 1 | 3 | 10.0 | CC/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL166759 | 57283 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 673 | 11 | 1 | 3 | 10.0 | CC/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44318593 | 167431 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 552 | 4 | 2 | 3 | 5.0 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(CCc1c[nH]c3ccccc13)C2=O | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL431974 | 167431 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 552 | 4 | 2 | 3 | 5.0 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(CCc1c[nH]c3ccccc13)C2=O | 10.1016/s0960-894x(02)00488-2 | ||
44281787 | 162648 | 0 | None | -14 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 597 | 11 | 1 | 6 | 6.2 | CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL418224 | 162648 | 0 | None | -14 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 597 | 11 | 1 | 6 | 6.2 | CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
49863733 | 15159 | 0 | None | 2 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1477 | 21 | 11 | 14 | 6.8 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm100157m | ||
CHEMBL1214026 | 15159 | 0 | None | 2 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1477 | 21 | 11 | 14 | 6.8 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1021/jm100157m | ||
118730932 | 117653 | 0 | None | -2951 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 834 | 15 | 7 | 7 | 3.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408518 | 117653 | 0 | None | -2951 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 834 | 15 | 7 | 7 | 3.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
44364003 | 118490 | 0 | None | 9 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 681 | 11 | 0 | 5 | 8.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL342572 | 118490 | 0 | None | 9 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 681 | 11 | 0 | 5 | 8.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
10295489 | 139812 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 418 | 5 | 2 | 2 | 4.4 | O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)N1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL380716 | 139812 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 418 | 5 | 2 | 2 | 4.4 | O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)N1 | 10.1016/j.bmcl.2005.10.072 | ||
44281957 | 99355 | 0 | None | 27 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 703 | 10 | 1 | 5 | 8.1 | CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL285475 | 99355 | 0 | None | 27 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 703 | 10 | 1 | 5 | 8.1 | CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
10010096 | 99428 | 0 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 719 | 10 | 1 | 6 | 8.6 | CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL285986 | 99428 | 0 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 719 | 10 | 1 | 6 | 8.6 | CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
24768356 | 155321 | 0 | None | -4 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1091 | 22 | 8 | 9 | 5.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm070332f | ||
CHEMBL406030 | 155321 | 0 | None | -4 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1091 | 22 | 8 | 9 | 5.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm070332f | ||
10675169 | 108172 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 605 | 9 | 2 | 4 | 4.9 | CN(C)C(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL320758 | 108172 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 605 | 9 | 2 | 4 | 4.9 | CN(C)C(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 | 10.1021/jm970499g | ||
44408846 | 140015 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 550 | 5 | 0 | 4 | 6.1 | Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL381081 | 140015 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 550 | 5 | 0 | 4 | 6.1 | Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
14991605 | 90641 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 325 | 8 | 3 | 3 | 1.2 | NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm400209h | ||
CHEMBL2397492 | 90641 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 325 | 8 | 3 | 3 | 1.2 | NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm400209h | ||
10229773 | 75150 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 520 | 6 | 1 | 3 | 5.5 | O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCOCC1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL204296 | 75150 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 520 | 6 | 1 | 3 | 5.5 | O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCOCC1 | 10.1016/j.bmcl.2005.10.072 | ||
44407906 | 74359 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 715 | 11 | 1 | 6 | 6.7 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL203064 | 74359 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 715 | 11 | 1 | 6 | 6.7 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2005.10.077 | ||
44408048 | 140028 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 667 | 9 | 1 | 6 | 6.1 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL381157 | 140028 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 667 | 9 | 1 | 6 | 6.1 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 | 10.1016/j.bmcl.2005.10.077 | ||
44407903 | 140191 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 655 | 9 | 1 | 6 | 6.0 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 | 10.1016/j.bmcl.2005.10.077 | ||
CHEMBL381778 | 140191 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 655 | 9 | 1 | 6 | 6.0 | C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 | 10.1016/j.bmcl.2005.10.077 | ||
44338586 | 6807 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 4.9 | COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL108422 | 6807 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 4.9 | COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 | 10.1016/s0960-894x(02)00956-3 | ||
44338584 | 8073 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 500 | 6 | 1 | 3 | 6.2 | FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL109183 | 8073 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 500 | 6 | 1 | 3 | 6.2 | FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
10187704 | 118919 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 556 | 11 | 1 | 6 | 5.1 | FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCCCc3nnn[nH]3)CC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL344847 | 118919 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 556 | 11 | 1 | 6 | 5.1 | FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCCCc3nnn[nH]3)CC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
20599010 | 197686 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 503 | 2 | 1 | 2 | 6.1 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
CHEMBL590833 | 197686 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 503 | 2 | 1 | 2 | 6.1 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
118730933 | 117654 | 0 | None | -389 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 698 | 15 | 7 | 7 | 1.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3408519 | 117654 | 0 | None | -389 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 698 | 15 | 7 | 7 | 1.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
10578261 | 9093 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 535 | 8 | 2 | 4 | 4.6 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 | 10.1021/jm970499g | ||
CHEMBL110301 | 9093 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 535 | 8 | 2 | 4 | 4.6 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 | 10.1021/jm970499g | ||
127033168 | 138245 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1021 | 17 | 7 | 8 | 5.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3780686 | 138245 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1021 | 17 | 7 | 8 | 5.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
56668794 | 65578 | 0 | None | 17 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 806 | 15 | 2 | 5 | 8.9 | O=C(CCCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.08.027 | ||
CHEMBL1835844 | 65578 | 0 | None | 17 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 806 | 15 | 2 | 5 | 8.9 | O=C(CCCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2011.08.027 | ||
44177145 | 194055 | 0 | None | -6 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1191 | 27 | 10 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
CHEMBL557188 | 194055 | 0 | None | -6 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1191 | 27 | 10 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900473p | ||
9874473 | 41564 | 0 | None | 16 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 659 | 10 | 0 | 4 | 8.4 | CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm030197g | ||
CHEMBL149326 | 41564 | 0 | None | 16 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 659 | 10 | 0 | 4 | 8.4 | CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 | 10.1021/jm030197g | ||
71549635 | 160327 | 0 | None | -851 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 450 | 4 | 0 | 8 | 4.4 | C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 | nan | ||
CHEMBL4115030 | 160327 | 0 | None | -851 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 450 | 4 | 0 | 8 | 4.4 | C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 | nan | ||
145948955 | 166926 | 0 | None | -18 | 4 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1091 | 22 | 8 | 9 | 5.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
CHEMBL4299466 | 166926 | 0 | None | -18 | 4 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1091 | 22 | 8 | 9 | 5.0 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.5b01170 | ||
44314597 | 103872 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 599 | 10 | 0 | 5 | 7.0 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL310019 | 103872 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 599 | 10 | 0 | 5 | 7.0 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
118731113 | 117666 | 0 | None | -43651 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 670 | 14 | 8 | 7 | 1.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2ccccc2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408730 | 117666 | 0 | None | -43651 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 670 | 14 | 8 | 7 | 1.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2ccccc2)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
44314298 | 203432 | 0 | None | 4 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 682 | 13 | 1 | 6 | 6.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL78065 | 203432 | 0 | None | 4 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 682 | 13 | 1 | 6 | 6.6 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
10001148 | 51170 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 402 | 6 | 2 | 2 | 5.3 | CNC(c1ccccc1)C1(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 | 10.1016/s0960-894x(01)00020-8 | ||
CHEMBL158212 | 51170 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 402 | 6 | 2 | 2 | 5.3 | CNC(c1ccccc1)C1(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 | 10.1016/s0960-894x(01)00020-8 | ||
90644622 | 112248 | 0 | None | 25 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 697 | 12 | 3 | 6 | 5.6 | CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288162 | 112248 | 0 | None | 25 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 697 | 12 | 3 | 6 | 5.6 | CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3305013 | 112248 | 0 | None | 25 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 697 | 12 | 3 | 6 | 5.6 | CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
44358413 | 26701 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 504 | 7 | 0 | 4 | 5.8 | CCOC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL136389 | 26701 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 504 | 7 | 0 | 4 | 5.8 | CCOC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
44358551 | 29121 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 514 | 8 | 1 | 6 | 4.3 | FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3nn[nH]n3)CC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL138335 | 29121 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 514 | 8 | 1 | 6 | 4.3 | FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3nn[nH]n3)CC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
20599010 | 197686 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 503 | 2 | 1 | 2 | 6.1 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
CHEMBL590833 | 197686 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 503 | 2 | 1 | 2 | 6.1 | Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2009.11.078 | ||
2089 | 2725 | 21 | None | -102 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00219-4 | ||||
3795 | 2725 | 21 | None | -102 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00219-4 | ||||
5311311 | 2725 | 21 | None | -102 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00219-4 | ||||
CHEMBL217406 | 2725 | 21 | None | -102 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(98)00219-4 | ||||
90644612 | 112223 | 0 | None | 3 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 669 | 10 | 2 | 6 | 5.5 | CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288157 | 112223 | 0 | None | 3 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 669 | 10 | 2 | 6 | 5.5 | CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3304538 | 112223 | 0 | None | 3 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 669 | 10 | 2 | 6 | 5.5 | CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
90644618 | 112266 | 0 | None | 3 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3288160 | 112266 | 0 | None | 3 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
CHEMBL3305331 | 112266 | 0 | None | 3 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 683 | 11 | 3 | 6 | 5.2 | CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 | 10.1021/ml400528y | ||
44304381 | 101615 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 507 | 3 | 2 | 2 | 6.0 | O=C1CN(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(c2ccccc2)c2ccccc2N1 | 10.1016/S0960-894X(97)00353-3 | ||
CHEMBL302163 | 101615 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 507 | 3 | 2 | 2 | 6.0 | O=C1CN(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(c2ccccc2)c2ccccc2N1 | 10.1016/S0960-894X(97)00353-3 | ||
7037588 | 197601 | 1 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 | 10.1021/jm901352b | ||
CHEMBL590276 | 197601 | 1 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 | 10.1021/jm901352b | ||
44318874 | 203953 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 581 | 3 | 0 | 3 | 6.1 | CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3c(Cl)cccc3Cl)CC2)C1=O | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL82065 | 203953 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 581 | 3 | 0 | 3 | 6.1 | CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3c(Cl)cccc3Cl)CC2)C1=O | 10.1016/s0960-894x(02)00488-2 | ||
3198 | 203802 | 73 | None | -37 | 34 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | ||
CHEMBL1201049 | 203802 | 73 | None | -37 | 34 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | ||
CHEMBL808 | 203802 | 73 | None | -37 | 34 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | nan | ||
131954513 | 161529 | 31 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 357 | 2 | 0 | 4 | 4.3 | COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F | 10.1021/acsmedchemlett.7b00317 | ||
CHEMBL4160748 | 161529 | 31 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 357 | 2 | 0 | 4 | 4.3 | COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F | 10.1021/acsmedchemlett.7b00317 | ||
11683187 | 198250 | 35 | None | -676 | 5 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
CHEMBL594828 | 198250 | 35 | None | -676 | 5 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
8867347 | 60279 | 6 | None | -6 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 362 | 4 | 1 | 4 | 3.0 | COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 | 10.1016/j.bmcl.2011.02.033 | ||
CHEMBL1760200 | 60279 | 6 | None | -6 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 362 | 4 | 1 | 4 | 3.0 | COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 | 10.1016/j.bmcl.2011.02.033 | ||
44408821 | 75041 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 465 | 4 | 0 | 1 | 7.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL203928 | 75041 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 465 | 4 | 0 | 1 | 7.3 | CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2005.11.047 | ||
73352066 | 90640 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 325 | 7 | 3 | 3 | 1.3 | C[C@H](c1ccccc1)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
CHEMBL2397491 | 90640 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 325 | 7 | 3 | 3 | 1.3 | C[C@H](c1ccccc1)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
44363435 | 36957 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 785 | 14 | 0 | 5 | 9.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL145314 | 36957 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 785 | 14 | 0 | 5 | 9.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44380733 | 58308 | 0 | None | 7 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 720 | 14 | 1 | 6 | 8.7 | COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL168437 | 58308 | 0 | None | 7 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 720 | 14 | 1 | 6 | 8.7 | COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44363983 | 17982 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 769 | 15 | 2 | 7 | 7.4 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL126970 | 17982 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 769 | 15 | 2 | 7 | 7.4 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44281958 | 109199 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 646 | 10 | 1 | 6 | 6.4 | CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL32273 | 109199 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 646 | 10 | 1 | 6 | 6.4 | CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44337289 | 107552 | 0 | None | 3 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 624 | 9 | 1 | 6 | 5.3 | COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL319474 | 107552 | 0 | None | 3 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 624 | 9 | 1 | 6 | 5.3 | COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
46227363 | 197984 | 0 | None | -28 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL592969 | 197984 | 0 | None | -28 | 4 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1210 | 16 | 10 | 12 | 4.7 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/j.bmc.2009.08.035 | ||
10651575 | 5085 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 624 | 10 | 2 | 3 | 6.6 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL105847 | 5085 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 624 | 10 | 2 | 3 | 6.6 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl | 10.1021/jm970499g | ||
25129133 | 188300 | 0 | None | -1122 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800389v | ||
CHEMBL507340 | 188300 | 0 | None | -1122 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm800389v | ||
25129133 | 188300 | 0 | None | -1122 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
CHEMBL507340 | 188300 | 0 | None | -1122 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1208 | 27 | 10 | 11 | 4.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2009.08.035 | ||
44380069 | 57312 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 714 | 14 | 0 | 6 | 8.1 | CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL166842 | 57312 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 714 | 14 | 0 | 6 | 8.1 | CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
127031644 | 138305 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1007 | 16 | 7 | 8 | 5.3 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3781336 | 138305 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1007 | 16 | 7 | 8 | 5.3 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
44337288 | 7963 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 632 | 7 | 1 | 4 | 6.6 | O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL109092 | 7963 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 632 | 7 | 1 | 4 | 6.6 | O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
52937467 | 62194 | 0 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 820 | 14 | 7 | 7 | 3.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL1782141 | 62194 | 0 | None | -9 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 820 | 14 | 7 | 7 | 3.4 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL2419538 | 208694 | 0 | None | -117 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC1(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCC1 | 10.1016/j.bmcl.2013.06.065 | ||||
10140125 | 27073 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 471 | 7 | 0 | 4 | 5.1 | N#CCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL136709 | 27073 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 471 | 7 | 0 | 4 | 5.1 | N#CCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
20811360 | 30112 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 489 | 8 | 1 | 4 | 4.1 | NC(=O)CN1CCN([C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL139150 | 30112 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 489 | 8 | 1 | 4 | 4.1 | NC(=O)CN1CCN([C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/s0960-894x(02)00956-3 | ||
44358247 | 118502 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 438 | 6 | 1 | 4 | 4.9 | FC(F)(F)c1cc(COCC(c2cccs2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL342602 | 118502 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 438 | 6 | 1 | 4 | 4.9 | FC(F)(F)c1cc(COCC(c2cccs2)N2CCNCC2)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00956-3 | ||
44338640 | 167526 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 482 | 7 | 1 | 4 | 4.4 | COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL432627 | 167526 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 482 | 7 | 1 | 4 | 4.4 | COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 | 10.1016/s0960-894x(02)00956-3 | ||
44337324 | 6633 | 0 | None | -2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 688 | 8 | 3 | 5 | 5.3 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL108364 | 6633 | 0 | None | -2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 688 | 8 | 3 | 5 | 5.3 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
44314548 | 102436 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 663 | 11 | 0 | 7 | 7.3 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL306052 | 102436 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 663 | 11 | 0 | 7 | 7.3 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44281516 | 99420 | 0 | None | -3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 608 | 11 | 1 | 5 | 8.0 | CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL285929 | 99420 | 0 | None | -3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 608 | 11 | 1 | 5 | 8.0 | CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
73352065 | 90632 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 325 | 7 | 3 | 3 | 1.2 | C[C@](N)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
CHEMBL2397483 | 90632 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 325 | 7 | 3 | 3 | 1.2 | C[C@](N)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
44550460 | 195361 | 0 | None | -5 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 537 | 8 | 0 | 3 | 5.9 | CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm900948q | ||
CHEMBL567198 | 195361 | 0 | None | -5 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 537 | 8 | 0 | 3 | 5.9 | CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm900948q | ||
25129135 | 172028 | 0 | None | -1584 | 4 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1073 | 27 | 10 | 11 | 2.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 | 10.1021/jm800389v | ||
CHEMBL448998 | 172028 | 0 | None | -1584 | 4 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1073 | 27 | 10 | 11 | 2.9 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 | 10.1021/jm800389v | ||
73347011 | 88979 | 0 | None | 1 | 2 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 730 | 6 | 7 | 8 | -0.6 | COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 | 10.1021/jm00029a007 | ||
CHEMBL2370511 | 88979 | 0 | None | 1 | 2 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 730 | 6 | 7 | 8 | -0.6 | COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 | 10.1021/jm00029a007 | ||
44409000 | 168375 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 423 | 5 | 0 | 1 | 7.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL438801 | 168375 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 423 | 5 | 0 | 1 | 7.0 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2005.11.047 | ||
118731118 | 117671 | 0 | None | -1202 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 822 | 17 | 7 | 7 | 3.5 | Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408735 | 117671 | 0 | None | -1202 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 822 | 17 | 7 | 7 | 3.5 | Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.ejmech.2014.12.033 | ||
44318486 | 104942 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 613 | 6 | 1 | 4 | 5.3 | O=C1NC2(CCN(S(=O)(=O)CCc3cccc4ccccc34)CC2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00488-2 | ||
CHEMBL311946 | 104942 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 613 | 6 | 1 | 4 | 5.3 | O=C1NC2(CCN(S(=O)(=O)CCc3cccc4ccccc34)CC2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00488-2 | ||
118731116 | 117669 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 876 | 17 | 7 | 7 | 4.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
CHEMBL3408733 | 117669 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 876 | 17 | 7 | 7 | 4.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O | 10.1016/j.ejmech.2014.12.033 | ||
44281743 | 99178 | 0 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 690 | 11 | 1 | 5 | 9.1 | CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL284244 | 99178 | 0 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 690 | 11 | 1 | 5 | 9.1 | CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44334630 | 109167 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 684 | 4 | 0 | 7 | 4.8 | Cc1noc(C)c1S(=O)(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL322453 | 109167 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 684 | 4 | 0 | 7 | 4.8 | Cc1noc(C)c1S(=O)(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/s0960-894x(02)00659-5 | ||
10721590 | 7582 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 559 | 10 | 2 | 5 | 4.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
CHEMBL108847 | 7582 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 559 | 10 | 2 | 5 | 4.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] | 10.1021/jm970499g | ||
10746828 | 6864 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 650 | 9 | 2 | 3 | 6.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm970499g | ||
CHEMBL108448 | 6864 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 650 | 9 | 2 | 3 | 6.4 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm970499g | ||
CHEMBL2372068 | 208431 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | None | None | None | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC(Cc2ccccc2)[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/s0960-894x(98)00219-4 | ||||
73212515 | 104125 | 0 | None | 125 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 559 | 8 | 1 | 4 | 4.7 | CN(CCN1CCOCC1)C(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL3104778 | 104125 | 0 | None | 125 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 559 | 8 | 1 | 4 | 4.7 | CN(CCN1CCOCC1)C(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2013.12.033 | ||
44338510 | 8546 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 5.0 | Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 | 10.1016/s0960-894x(02)00956-3 | ||
CHEMBL109514 | 8546 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 450 | 6 | 1 | 3 | 5.0 | Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 | 10.1016/s0960-894x(02)00956-3 | ||
57394644 | 68023 | 0 | None | - | 1 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 721 | 10 | 4 | 6 | 4.3 | COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 | 10.1016/j.ejmech.2011.08.042 | ||
CHEMBL1916633 | 68023 | 0 | None | - | 1 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 721 | 10 | 4 | 6 | 4.3 | COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 | 10.1016/j.ejmech.2011.08.042 | ||
44334582 | 161144 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 597 | 3 | 0 | 5 | 4.1 | COc1ccccc1C(=O)N1CC2C(=O)N(C)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL413383 | 161144 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 597 | 3 | 0 | 5 | 4.1 | COc1ccccc1C(=O)N1CC2C(=O)N(C)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 | 10.1016/s0960-894x(02)00659-5 | ||
73212519 | 104120 | 0 | None | 12 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 3.6 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 | 10.1016/j.bmcl.2013.12.033 | ||
CHEMBL3104773 | 104120 | 0 | None | 12 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 3.6 | O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 | 10.1016/j.bmcl.2013.12.033 | ||
44304323 | 100118 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 544 | 4 | 1 | 4 | 4.6 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1CN1CCOCC1 | 10.1016/S0960-894X(97)00353-3 | ||
CHEMBL291650 | 100118 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 544 | 4 | 1 | 4 | 4.6 | CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1CN1CCOCC1 | 10.1016/S0960-894X(97)00353-3 | ||
90417914 | 118360 | 0 | None | -2570 | 5 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 433 | 4 | 0 | 7 | 5.0 | CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 | 10.1021/jm5017413 | ||
CHEMBL3422015 | 118360 | 0 | None | -2570 | 5 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 433 | 4 | 0 | 7 | 5.0 | CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 | 10.1021/jm5017413 | ||
9887650 | 16472 | 0 | None | -6309 | 5 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 407 | 5 | 1 | 3 | 4.3 | O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 | 10.1021/jm00019a006 | ||
CHEMBL124208 | 16472 | 0 | None | -6309 | 5 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 407 | 5 | 1 | 3 | 4.3 | O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 | 10.1021/jm00019a006 | ||
44380794 | 119777 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 720 | 13 | 2 | 6 | 8.2 | O=C(O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL352614 | 119777 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 720 | 13 | 2 | 6 | 8.2 | O=C(O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
10078301 | 118727 | 0 | None | 2 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 681 | 12 | 0 | 5 | 8.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL343447 | 118727 | 0 | None | 2 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 681 | 12 | 0 | 5 | 8.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44364002 | 120535 | 0 | None | 8 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 627 | 11 | 1 | 5 | 6.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL356796 | 120535 | 0 | None | 8 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 627 | 11 | 1 | 5 | 6.9 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
127033173 | 138315 | 0 | None | -2 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1062 | 16 | 7 | 9 | 5.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3781519 | 138315 | 0 | None | -2 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1062 | 16 | 7 | 9 | 5.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O | 10.1021/acsmedchemlett.5b00359 | ||
9872295 | 12513 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
CHEMBL1187084 | 12513 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
CHEMBL489924 | 12513 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 491 | 3 | 1 | 2 | 5.9 | Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
44334499 | 106816 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 652 | 4 | 0 | 6 | 3.7 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)CN1CCOCC1 | 10.1016/s0960-894x(02)00659-5 | ||
CHEMBL317238 | 106816 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 652 | 4 | 0 | 6 | 3.7 | O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)CN1CCOCC1 | 10.1016/s0960-894x(02)00659-5 | ||
127032846 | 138262 | 0 | None | 4 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1081 | 24 | 9 | 9 | 5.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1021/acsmedchemlett.5b00359 | ||
CHEMBL3780818 | 138262 | 0 | None | 4 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1081 | 24 | 9 | 9 | 5.7 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 | 10.1021/acsmedchemlett.5b00359 | ||
85169 | 6837 | 6 | None | -2 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm400209h | ||
CHEMBL108438 | 6837 | 6 | None | -2 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 311 | 7 | 3 | 3 | 0.8 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm400209h | ||
9846662 | 75559 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 452 | 4 | 0 | 2 | 6.4 | Cc1ccccc1-c1ccncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL204958 | 75559 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 452 | 4 | 0 | 2 | 6.4 | Cc1ccccc1-c1ccncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.11.047 | ||
3668 | 1531 | 36 | None | -38 | 10 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm901352b | ||||
5311081 | 1531 | 36 | None | -38 | 10 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm901352b | ||||
CHEMBL333357 | 1531 | 36 | None | -38 | 10 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm901352b | ||||
CHEMBL589982 | 1531 | 36 | None | -38 | 10 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm901352b | ||||
3668 | 1531 | 36 | None | -38 | 10 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2018.06.009 | ||||
5311081 | 1531 | 36 | None | -38 | 10 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2018.06.009 | ||||
CHEMBL333357 | 1531 | 36 | None | -38 | 10 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2018.06.009 | ||||
CHEMBL589982 | 1531 | 36 | None | -38 | 10 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2018.06.009 | ||||
10299289 | 192015 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 477 | 4 | 1 | 3 | 4.6 | Cc1cc(F)ccc1N1CCNCC1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
CHEMBL521605 | 192015 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 477 | 4 | 1 | 3 | 4.6 | Cc1cc(F)ccc1N1CCNCC1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1021/jm900023b | ||
10232846 | 113617 | 0 | None | 11 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 623 | 7 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1021/jm030786m | ||
CHEMBL332793 | 113617 | 0 | None | 11 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 623 | 7 | 2 | 3 | 6.1 | CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 | 10.1021/jm030786m | ||
10767720 | 78282 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 500 | 8 | 2 | 3 | 4.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)Nc1ccccc1 | 10.1021/jm970499g | ||
CHEMBL2112476 | 78282 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 500 | 8 | 2 | 3 | 4.2 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)Nc1ccccc1 | 10.1021/jm970499g | ||
73351579 | 88975 | 0 | None | -2 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 800 | 7 | 9 | 9 | 0.1 | CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O | 10.1021/jm00029a007 | ||
CHEMBL2370507 | 88975 | 0 | None | -2 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 800 | 7 | 9 | 9 | 0.1 | CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O | 10.1021/jm00029a007 | ||
10792994 | 7433 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 560 | 7 | 2 | 3 | 4.5 | O=C(N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc2C1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl | 10.1021/jm970499g | ||
CHEMBL108725 | 7433 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 560 | 7 | 2 | 3 | 4.5 | O=C(N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc2C1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl | 10.1021/jm970499g | ||
44380763 | 119528 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 690 | 12 | 1 | 5 | 9.1 | CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
CHEMBL350360 | 119528 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 690 | 12 | 1 | 5 | 9.1 | CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(02)00027-6 | ||
44281476 | 99469 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 662 | 10 | 1 | 5 | 8.6 | CO/N=C(\COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL286235 | 99469 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 662 | 10 | 1 | 5 | 8.6 | CO/N=C(\COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44314533 | 105199 | 0 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 710 | 12 | 0 | 6 | 7.4 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL312539 | 105199 | 0 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 710 | 12 | 0 | 6 | 7.4 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44314946 | 203354 | 0 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 726 | 14 | 0 | 6 | 8.0 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL77235 | 203354 | 0 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 726 | 14 | 0 | 6 | 8.0 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
1016 | 3690 | 75 | None | -39 | 35 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
2561 | 3690 | 75 | None | -39 | 35 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
2733526 | 3690 | 75 | None | -39 | 35 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
5384 | 3690 | 75 | None | -39 | 35 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
CHEMBL83 | 3690 | 75 | None | -39 | 35 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
DB00675 | 3690 | 75 | None | -39 | 35 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
2247 | 502 | 77 | None | -117 | 41 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
249 | 502 | 77 | None | -117 | 41 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
2603 | 502 | 77 | None | -117 | 41 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
CHEMBL296419 | 502 | 77 | None | -117 | 41 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
DB00637 | 502 | 77 | None | -117 | 41 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | nan | ||
2812 | 4711 | 96 | None | -43 | 34 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
CHEMBL104 | 4711 | 96 | None | -43 | 34 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
44407932 | 75544 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 436 | 5 | 2 | 2 | 4.6 | O=C1NC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL204918 | 75544 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 436 | 5 | 2 | 2 | 4.6 | O=C1NC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 | 10.1016/j.bmcl.2005.10.072 | ||
9940831 | 14477 | 0 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 810 | 13 | 4 | 9 | 5.7 | O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 | 10.1016/S0960-894X(96)00604-X | ||
CHEMBL1205204 | 14477 | 0 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 810 | 13 | 4 | 9 | 5.7 | O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 | 10.1016/S0960-894X(96)00604-X | ||
CHEMBL65468 | 14477 | 0 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 810 | 13 | 4 | 9 | 5.7 | O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 | 10.1016/S0960-894X(96)00604-X | ||
10032406 | 39714 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 667 | 11 | 0 | 5 | 7.8 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
CHEMBL147824 | 39714 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 667 | 11 | 0 | 5 | 7.8 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00702-2 | ||
44314868 | 155157 | 0 | None | 3 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 705 | 13 | 3 | 5 | 7.1 | NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
CHEMBL405129 | 155157 | 0 | None | 3 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 705 | 13 | 3 | 5 | 7.1 | NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00463-7 | ||
44314487 | 102440 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 753 | 13 | 1 | 7 | 6.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
CHEMBL306097 | 102440 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 753 | 13 | 1 | 7 | 6.1 | CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00464-9 | ||
44281672 | 113025 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 596 | 10 | 1 | 6 | 6.2 | CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL33215 | 113025 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 596 | 10 | 1 | 6 | 6.2 | CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL387816 | 210665 | 0 | None | 23 | 2 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm901352b | ||||
44611292 | 90633 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 325 | 7 | 2 | 3 | 1.1 | CN(C(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
CHEMBL2397484 | 90633 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 325 | 7 | 2 | 3 | 1.1 | CN(C(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm400209h | ||
44305818 | 14626 | 0 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 698 | 13 | 3 | 8 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 | 10.1016/S0960-894X(96)00604-X | ||
CHEMBL1206764 | 14626 | 0 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 698 | 13 | 3 | 8 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 | 10.1016/S0960-894X(96)00604-X | ||
CHEMBL305119 | 14626 | 0 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 698 | 13 | 3 | 8 | 4.3 | CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 | 10.1016/S0960-894X(96)00604-X | ||
CHEMBL2419539 | 208695 | 0 | None | -81 | 4 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2013.06.065 | ||||
44337173 | 6611 | 0 | None | -30 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 582 | 7 | 2 | 5 | 4.6 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL108350 | 6611 | 0 | None | -30 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 582 | 7 | 2 | 5 | 4.6 | Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 | 10.1016/s0960-894x(02)00645-5 | ||
122187725 | 122551 | 0 | None | -107 | 4 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 691 | 11 | 6 | 5 | 4.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
CHEMBL3609621 | 122551 | 0 | None | -107 | 4 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 691 | 11 | 6 | 5 | 4.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2015.06.030 | ||
44281358 | 97811 | 0 | None | 3 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 674 | 11 | 1 | 4 | 9.5 | CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL274557 | 97811 | 0 | None | 3 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 674 | 11 | 1 | 4 | 9.5 | CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
44337266 | 5226 | 0 | None | -27 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 564 | 7 | 1 | 4 | 5.3 | O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
CHEMBL106608 | 5226 | 0 | None | -27 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 564 | 7 | 1 | 4 | 5.3 | O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/s0960-894x(02)00645-5 | ||
44407896 | 138132 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 432 | 5 | 2 | 2 | 5.0 | C[C@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
CHEMBL377712 | 138132 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 432 | 5 | 2 | 2 | 5.0 | C[C@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2005.10.072 | ||
44408697 | 75080 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 409 | 4 | 1 | 3 | 6.8 | Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1c(Cl)cccc1Cl | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL204165 | 75080 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 409 | 4 | 1 | 3 | 6.8 | Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1c(Cl)cccc1Cl | 10.1016/j.bmcl.2005.11.047 | ||
73355028 | 90638 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 337 | 5 | 2 | 3 | 1.4 | NC(=O)[C@H]1[C@@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm400209h | ||
CHEMBL2397489 | 90638 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 337 | 5 | 2 | 3 | 1.4 | NC(=O)[C@H]1[C@@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 | 10.1021/jm400209h | ||
CHEMBL2111789 | 207475 | 0 | None | -3 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | None | None | None | CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O | 10.1021/jm00029a007 | ||||
44408910 | 140761 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 341 | 4 | 1 | 3 | 5.5 | Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2005.11.047 | ||
CHEMBL383289 | 140761 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 341 | 4 | 1 | 3 | 5.5 | Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2005.11.047 | ||
10409484 | 189069 | 1 | None | - | 1 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 413 | 0 | 2 | 6 | 0.9 | C[C@@]12NC(=O)[C@@H](C[C@@]13c1ccccc1N1C(=O)CN[C@@H]13)n1c2nc2ccccc2c1=O | 10.1021/np50106a005 | ||
CHEMBL515179 | 189069 | 1 | None | - | 1 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 413 | 0 | 2 | 6 | 0.9 | C[C@@]12NC(=O)[C@@H](C[C@@]13c1ccccc1N1C(=O)CN[C@@H]13)n1c2nc2ccccc2c1=O | 10.1021/np50106a005 | ||
44281753 | 99356 | 0 | None | -9 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 626 | 11 | 1 | 5 | 7.8 | CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
CHEMBL285476 | 99356 | 0 | None | -9 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 626 | 11 | 1 | 5 | 7.8 | CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00709-0 | ||
43815 | 186337 | 58 | None | - | 24 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | ||
CHEMBL1708 | 186337 | 58 | None | - | 24 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | ||
CHEMBL490 | 186337 | 58 | None | - | 24 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 329 | 4 | 1 | 4 | 3.3 | Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 | None | ||
132837 | 2207 | 51 | None | 18 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | Guide to Pharmacology | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 7509807 | ||
9461 | 2207 | 51 | None | 18 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | Guide to Pharmacology | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 7509807 | ||
CHEMBL22870 | 2207 | 51 | None | 18 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | Guide to Pharmacology | 472 | 6 | 2 | 3 | 5.0 | CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 | 7509807 | ||
9329 | 3684 | 3 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Guide to Pharmacology | 573 | 3 | 0 | 4 | 7.1 | C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 | 10508446 | ||
9894349 | 3684 | 3 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Guide to Pharmacology | 573 | 3 | 0 | 4 | 7.1 | C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 | 10508446 | ||
CHEMBL339486 | 3684 | 3 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | Guide to Pharmacology | 573 | 3 | 0 | 4 | 7.1 | C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 | 10508446 | ||
23653789 | 3530 | 19 | None | - | 2 | Human | 10.2 | pIC50 | = | 10.2 | Binding | Guide to Pharmacology | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 19354254 | ||
9280 | 3530 | 19 | None | - | 2 | Human | 10.2 | pIC50 | = | 10.2 | Binding | Guide to Pharmacology | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 19354254 | ||
CHEMBL447955 | 3530 | 19 | None | - | 2 | Human | 10.2 | pIC50 | = | 10.2 | Binding | Guide to Pharmacology | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 19354254 | ||
DB12973 | 3530 | 19 | None | - | 2 | Human | 10.2 | pIC50 | = | 10.2 | Binding | Guide to Pharmacology | 555 | 5 | 0 | 3 | 7.7 | O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F | 19354254 | ||
2098 | 3638 | 31 | None | 1 | 6 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 2410593 | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 2410593 | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 2410593 | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 2410593 | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 2410593 | ||||
9278 | 3789 | 0 | None | - | 1 | Human | 7.0 | pKi | < | 7 | Binding | Guide to Pharmacology | 587 | 6 | 0 | 6 | 7.4 | Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F | None | ||
9916461 | 3789 | 0 | None | - | 1 | Human | 7.0 | pKi | < | 7 | Binding | Guide to Pharmacology | 587 | 6 | 0 | 6 | 7.4 | Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F | None | ||
CHEMBL3544984 | 3789 | 0 | None | - | 1 | Human | 7.0 | pKi | < | 7 | Binding | Guide to Pharmacology | 587 | 6 | 0 | 6 | 7.4 | Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F | None | ||
DB12580 | 3789 | 0 | None | - | 1 | Human | 7.0 | pKi | < | 7 | Binding | Guide to Pharmacology | 587 | 6 | 0 | 6 | 7.4 | Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F | None | ||
2098 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
36511 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3805 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3835 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
CHEMBL235363 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
2098 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
36511 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3805 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3835 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
CHEMBL235363 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
2098 | 3638 | 31 | 125I-Bolton Hunter | -1 | 6 | Rat | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
36511 | 3638 | 31 | 125I-Bolton Hunter | -1 | 6 | Rat | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3805 | 3638 | 31 | 125I-Bolton Hunter | -1 | 6 | Rat | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3835 | 3638 | 31 | 125I-Bolton Hunter | -1 | 6 | Rat | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
CHEMBL235363 | 3638 | 31 | 125I-Bolton Hunter | -1 | 6 | Rat | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
2098 | 3638 | 31 | 125I-Bolton Hunter | -2 | 6 | Guinea pig | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
36511 | 3638 | 31 | 125I-Bolton Hunter | -2 | 6 | Guinea pig | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3805 | 3638 | 31 | 125I-Bolton Hunter | -2 | 6 | Guinea pig | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3835 | 3638 | 31 | 125I-Bolton Hunter | -2 | 6 | Guinea pig | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
CHEMBL235363 | 3638 | 31 | 125I-Bolton Hunter | -2 | 6 | Guinea pig | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
2098 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
36511 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3805 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3835 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
CHEMBL235363 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
2098 | 3638 | 31 | 125I-Bolton Hunter | -2 | 6 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
36511 | 3638 | 31 | 125I-Bolton Hunter | -2 | 6 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3805 | 3638 | 31 | 125I-Bolton Hunter | -2 | 6 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3835 | 3638 | 31 | 125I-Bolton Hunter | -2 | 6 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
CHEMBL235363 | 3638 | 31 | 125I-Bolton Hunter | -2 | 6 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
2098 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
36511 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3805 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3835 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
CHEMBL235363 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
2098 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
36511 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3805 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3835 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
CHEMBL235363 | 3638 | 31 | 125I-Bolton Hunter | 1 | 6 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
2098 | 3638 | 31 | 125I-Bolton Hunter | -1 | 6 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
36511 | 3638 | 31 | 125I-Bolton Hunter | -1 | 6 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3805 | 3638 | 31 | 125I-Bolton Hunter | -1 | 6 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3835 | 3638 | 31 | 125I-Bolton Hunter | -1 | 6 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
CHEMBL235363 | 3638 | 31 | 125I-Bolton Hunter | -1 | 6 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
None | 214433 | 0 | 125I-Bolton Hunter | 2 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 588 | 8 | 2 | 5 | 4.3 | CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O | None | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
230 | 444 | 80 | None | 50 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | None | ||
202 | 1480 | 0 | UNDEFINED | -9 | 31 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
60835 | 1480 | 0 | UNDEFINED | -9 | 31 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
972 | 1480 | 0 | UNDEFINED | -9 | 31 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
CHEMBL1175 | 1480 | 0 | UNDEFINED | -9 | 31 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
DB00476 | 1480 | 0 | UNDEFINED | -9 | 31 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
5656 | 201377 | 82 | UNDEFINED | -7 | 40 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | ||
CHEMBL637 | 201377 | 82 | UNDEFINED | -7 | 40 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | ||
54841 | 201437 | 51 | UNDEFINED | -1 | 28 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 255 | 6 | 1 | 2 | 3.7 | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 | None | ||
CHEMBL641 | 201437 | 51 | UNDEFINED | -1 | 28 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 255 | 6 | 1 | 2 | 3.7 | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 | None | ||
3075702 | 215594 | 0 | 3H-SP | -2 | 37 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 198 | 3 | 1 | 3 | 1.5 | C1CNC1COC2=CN=C(C=C2)Cl | None | ||
119376 | 1811 | 41 | 3H-SUBSTANCE P | -54954 | 26 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
247 | 1811 | 41 | 3H-SUBSTANCE P | -54954 | 26 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
CHEMBL33884 | 1811 | 41 | 3H-SUBSTANCE P | -54954 | 26 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
3294 | 1975 | 106 | 3H-Sar9SP | -14454 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
71360 | 1975 | 106 | 3H-Sar9SP | -14454 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
87 | 1975 | 106 | 3H-Sar9SP | -14454 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
CHEMBL14376 | 1975 | 106 | 3H-Sar9SP | -14454 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
DB04946 | 1975 | 106 | 3H-Sar9SP | -14454 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | ||
243 | 3153 | 85 | 3H-SUBSTANCE P | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
3052762 | 3153 | 85 | 3H-SUBSTANCE P | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
3502 | 3153 | 85 | 3H-SUBSTANCE P | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
CHEMBL117287 | 3153 | 85 | 3H-SUBSTANCE P | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
DB06480 | 3153 | 85 | 3H-SUBSTANCE P | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
21830793 | 91403 | 5 | 3H-8-OH-DPAT | -66069 | 46 | Bovine | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | None | ||
CHEMBL2413154 | 91403 | 5 | 3H-8-OH-DPAT | -66069 | 46 | Bovine | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | None | ||
133090 | 97971 | 18 | 125I-[MePhe7]-NKB | -630 | 3 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 382 | 5 | 2 | 3 | 5.5 | CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 | None | ||
CHEMBL275544 | 97971 | 18 | 125I-[MePhe7]-NKB | -630 | 3 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 382 | 5 | 2 | 3 | 5.5 | CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 | None | ||
44208932 | 140176 | 6 | UNDEFINED | -120226 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | ||
CHEMBL381689 | 140176 | 6 | UNDEFINED | -120226 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | ||
1973 | 201790 | 12 | 125I-[SAR9, Met(O2)11]-SP | -3 | 35 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | ||
CHEMBL1394464 | 201790 | 12 | 125I-[SAR9, Met(O2)11]-SP | -3 | 35 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | ||
CHEMBL66089 | 201790 | 12 | 125I-[SAR9, Met(O2)11]-SP | -3 | 35 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | ||
5079497 | 214303 | 0 | 125I-[MePhe7]-NKB | -1445 | 3 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 841 | 26 | 8 | 10 | -0.0 | CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)CCC(=O)O | None | ||
None | 214358 | 0 | 3H-Leu,4,5 Substance P | -1 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 164 | 3 | 1 | 3 | 0.8 | C1CNC1COC2=CN=CC=C2 | None | ||
119380 | 214359 | 0 | 3H-Leu,4,5 Substance P | -1 | 8 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 166 | 1 | 0 | 3 | 1.8 | CC1=NOC(=C1)C2CCCN2C | None | ||
None | 214752 | 0 | 3H-SUBSTANCE P | -10471285 | 17 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 372 | 2 | 1 | 3 | 4.4 | CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl | None | ||
None | 214304 | 0 | 125I-Bolton Hunter | -354 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 605 | 8 | 0 | 3 | 7.4 | CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 | None | ||
None | 214304 | 0 | 3H-SUBSTANCE P | -354 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 605 | 8 | 0 | 3 | 7.4 | CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 | None | ||
None | 214304 | 0 | 125I-Bolton Hunter | -354 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 605 | 8 | 0 | 3 | 7.4 | CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 | None | ||
2098 | 3638 | 31 | 125I-[MePhe7]-NKB | 1 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
36511 | 3638 | 31 | 125I-[MePhe7]-NKB | 1 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3805 | 3638 | 31 | 125I-[MePhe7]-NKB | 1 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
3835 | 3638 | 31 | 125I-[MePhe7]-NKB | 1 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
CHEMBL235363 | 3638 | 31 | 125I-[MePhe7]-NKB | 1 | 6 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
None | 214304 | 0 | 125I-Bolton Hunter | -1202 | 8 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 605 | 8 | 0 | 3 | 7.4 | CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 | None | ||
None | 214433 | 0 | 125I-Bolton Hunter | -1412 | 5 | Rat | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 588 | 8 | 2 | 5 | 4.3 | CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O | None | ||
None | 214434 | 0 | 125I-Bolton Hunter | -2 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 1041 | 17 | 10 | 13 | 0.9 | CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C | None | ||
9850582 | 195566 | 21 | 125I-Bolton Hunter | -309 | 6 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | None | ||
CHEMBL56835 | 195566 | 21 | 125I-Bolton Hunter | -309 | 6 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | None | ||
None | 214304 | 0 | 125I-Bolton Hunter | -354 | 8 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 605 | 8 | 0 | 3 | 7.4 | CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 | None | ||
None | 214434 | 0 | 125I-Bolton Hunter | -2 | 6 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 1041 | 17 | 10 | 13 | 0.9 | CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C | None | ||
9850582 | 195566 | 21 | 3H-Sar9,Met(O2)11-Substance P | -588 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | None | ||
CHEMBL56835 | 195566 | 21 | 3H-Sar9,Met(O2)11-Substance P | -588 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | None | ||
None | 214304 | 0 | 3H-Sar9,Met(O2)11-Substance P | -354 | 8 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 605 | 8 | 0 | 3 | 7.4 | CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 | None | ||
None | 214433 | 0 | 125I-Bolton Hunter | -2 | 5 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 588 | 8 | 2 | 5 | 4.3 | CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O | None | ||
None | 214304 | 0 | 125I-Bolton Hunter | -354 | 8 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 605 | 8 | 0 | 3 | 7.4 | CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 | None | ||
None | 214304 | 0 | 125I-Bolton Hunter | -354 | 8 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 605 | 8 | 0 | 3 | 7.4 | CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 | None | ||
9850582 | 195566 | 21 | 125I-[MePhe7]-NKB | -588 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | None | ||
CHEMBL56835 | 195566 | 21 | 125I-[MePhe7]-NKB | -588 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | None | ||
2812 | 4711 | 96 | None | -43 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
CHEMBL104 | 4711 | 96 | None | -43 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
2247 | 502 | 77 | None | -117 | 41 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
249 | 502 | 77 | None | -117 | 41 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
2603 | 502 | 77 | None | -117 | 41 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
CHEMBL296419 | 502 | 77 | None | -117 | 41 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
DB00637 | 502 | 77 | None | -117 | 41 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 458 | 8 | 1 | 5 | 5.4 | COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 | None | ||
1016 | 3690 | 75 | None | -39 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
2561 | 3690 | 75 | None | -39 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
2733526 | 3690 | 75 | None | -39 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
5384 | 3690 | 75 | None | -39 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
CHEMBL83 | 3690 | 75 | None | -39 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
DB00675 | 3690 | 75 | None | -39 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
3198 | 203802 | 73 | None | -37 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | None | ||
CHEMBL1201049 | 203802 | 73 | None | -37 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | None | ||
CHEMBL808 | 203802 | 73 | None | -37 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 380 | 6 | 0 | 3 | 5.8 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | None | ||
4189 | 205195 | 91 | None | -27 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | ||
CHEMBL1559 | 205195 | 91 | None | -27 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | ||
CHEMBL91 | 205195 | 91 | None | -27 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | ||
None | 214301 | 0 | 125I-[MePhe7]-NKB | -676 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 1210 | 38 | 14 | 16 | -1.6 | CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)N | None | ||
9850582 | 195566 | 21 | 125I-Bolton Hunter | -588 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | None | ||
CHEMBL56835 | 195566 | 21 | 125I-Bolton Hunter | -588 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | None | ||
None | 214304 | 0 | 125I-Bolton Hunter | -354 | 8 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 605 | 8 | 0 | 3 | 7.4 | CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 | None | ||
None | 214302 | 0 | 125I-[MePhe7]-NKB | -851 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 1133 | 37 | 16 | 17 | -4.6 | CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N | None | ||
None | 214304 | 0 | 125I-[MePhe7]-NKB | -354 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 605 | 8 | 0 | 3 | 7.4 | CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 | None | ||
4898 | 2724 | 78 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | None | ||
5742 | 2724 | 78 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | None | ||
6451149 | 2724 | 78 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | None | ||
CHEMBL206253 | 2724 | 78 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | None | ||
DB09048 | 2724 | 78 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | None | ||
71544786 | 216030 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 689 | 8 | 2 | 5 | 6.4 | CN(C(=O)C(C)(C)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C1=CN=C(C=C1C1=C(C)C=CC=C1)N1CC[N+](C)(COP(O)(O)=O)CC1 | None | ||
10311306 | 3315 | 47 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | None | ||
5027 | 3315 | 47 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | None | ||
5749 | 3315 | 47 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | None | ||
CHEMBL3707331 | 3315 | 47 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | None | ||
DB09291 | 3315 | 47 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | None | ||
23725089 | 791 | 8 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | None | ||
4401 | 791 | 8 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | None | ||
5758 | 791 | 8 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | None | ||
9917021 | 791 | 8 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | None | ||
CHEMBL1672054 | 791 | 8 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | None | ||
DB06634 | 791 | 8 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | None | ||
None | 214434 | 0 | 125I-Bolton Hunter | 2 | 6 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 1041 | 17 | 10 | 13 | 0.9 | CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C | None | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10737756 | ||
135413536 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 9804700 | ||
230 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10737756 | ||
230 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 9804700 | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10737756 | ||
3490 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 9804700 | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10737756 | ||
6918365 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 9804700 | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10737756 | ||
CHEMBL1471 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 9804700 | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10737756 | ||
DB00673 | 444 | 80 | None | 50 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 9804700 | ||
10158788 | 3671 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 415 | 6 | 2 | 4 | 5.0 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)c1ccc(cc1F)C#N | 18187929 | ||
5746 | 3671 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 415 | 6 | 2 | 4 | 5.0 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)c1ccc(cc1F)C#N | 18187929 | ||
5752 | 3942 | 20 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | Guide to Pharmacology | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 8876035 | ||
6918331 | 3942 | 20 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | Guide to Pharmacology | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 8876035 | ||
CHEMBL522302 | 3942 | 20 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | Guide to Pharmacology | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 8876035 | ||
DB12436 | 3942 | 20 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | Guide to Pharmacology | 432 | 6 | 2 | 7 | 3.3 | COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F | 8876035 | ||
2087 | 1889 | 0 | None | 31 | 4 | Human | 10.8 | pKi | = | 10.8 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
119137 | 3528 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
119137 | 3528 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 8985159 | ||||
2095 | 3528 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
2095 | 3528 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 8985159 | ||||
CHEMBL1885865 | 3528 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
CHEMBL1885865 | 3528 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 8985159 | ||||
5759 | 587 | 17 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | Guide to Pharmacology | 565 | 5 | 0 | 4 | 6.9 | O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C | 16332435 | ||
6450815 | 587 | 17 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | Guide to Pharmacology | 565 | 5 | 0 | 4 | 6.9 | O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C | 16332435 | ||
CHEMBL204694 | 587 | 17 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | Guide to Pharmacology | 565 | 5 | 0 | 4 | 6.9 | O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C | 16332435 | ||
4898 | 2724 | 78 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 16332435 | ||
5742 | 2724 | 78 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 16332435 | ||
6451149 | 2724 | 78 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 16332435 | ||
CHEMBL206253 | 2724 | 78 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 16332435 | ||
DB09048 | 2724 | 78 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 578 | 5 | 0 | 4 | 6.8 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C | 16332435 | ||
107967 | 1616 | 0 | None | 1000 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 588 | 8 | 2 | 5 | 4.3 | O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 | 8630576 | ||
2114 | 1616 | 0 | None | 1000 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 588 | 8 | 2 | 5 | 4.3 | O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 | 8630576 | ||
CHEMBL1416993 | 1616 | 0 | None | 1000 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 588 | 8 | 2 | 5 | 4.3 | O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 | 8630576 | ||
10311306 | 3315 | 47 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | 22497992 | ||
5027 | 3315 | 47 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | 22497992 | ||
5749 | 3315 | 47 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | 22497992 | ||
CHEMBL3707331 | 3315 | 47 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | 22497992 | ||
DB09291 | 3315 | 47 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 500 | 5 | 2 | 3 | 5.7 | O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 | 22497992 | ||
10462 | 1985 | 7 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 550 | 5 | 0 | 4 | 6.1 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 16332435 | ||
9808518 | 1985 | 7 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 550 | 5 | 0 | 4 | 6.1 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 16332435 | ||
CHEMBL206488 | 1985 | 7 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 550 | 5 | 0 | 4 | 6.1 | CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 16332435 | ||
5754 | 3215 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 660 | 7 | 1 | 4 | 6.8 | O=C(Nc1c(C)cccc1C)CN1CCN(CC1)[C@H]1CCN([C@@H](C1)Cc1ccccc1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F | 12130734 | ||
9917716 | 3215 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 660 | 7 | 1 | 4 | 6.8 | O=C(Nc1c(C)cccc1C)CN1CCN(CC1)[C@H]1CCN([C@@H](C1)Cc1ccccc1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F | 12130734 | ||
5757 | 3923 | 10 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 18657401 | ||
5757 | 3923 | 10 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 19388677 | ||
9832383 | 3923 | 10 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 18657401 | ||
9832383 | 3923 | 10 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 19388677 | ||
CHEMBL522987 | 3923 | 10 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 18657401 | ||
CHEMBL522987 | 3923 | 10 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 19388677 | ||
DB11949 | 3923 | 10 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 18657401 | ||
DB11949 | 3923 | 10 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 491 | 3 | 1 | 2 | 5.9 | Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C | 19388677 | ||
23725089 | 791 | 8 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 20533894 | ||
23725089 | 791 | 8 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 24106886 | ||
4401 | 791 | 8 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 20533894 | ||
4401 | 791 | 8 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 24106886 | ||
5758 | 791 | 8 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 20533894 | ||
5758 | 791 | 8 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 24106886 | ||
9917021 | 791 | 8 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 20533894 | ||
9917021 | 791 | 8 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 24106886 | ||
CHEMBL1672054 | 791 | 8 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 20533894 | ||
CHEMBL1672054 | 791 | 8 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 24106886 | ||
DB06634 | 791 | 8 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 20533894 | ||
DB06634 | 791 | 8 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 616 | 4 | 0 | 3 | 6.7 | Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C | 24106886 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 12206858 | ||
2102 | 1166 | 17 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 9190866 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 12206858 | ||
5311057 | 1166 | 17 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 9190866 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 12206858 | ||
CHEMBL441225 | 1166 | 17 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 296 | 5 | 2 | 3 | 3.3 | COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 | 9190866 | ||
188927 | 1585 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | 454 | 8 | 1 | 3 | 6.2 | COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C | 12372904 | ||
5751 | 1585 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | 454 | 8 | 1 | 3 | 6.2 | COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C | 12372904 | ||
CHEMBL515966 | 1585 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | 454 | 8 | 1 | 3 | 6.2 | COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C | 12372904 | ||
3086681 | 2240 | 14 | None | 89125 | 3 | Human | 9.9 | pKi | = | 9.9 | Binding | Guide to Pharmacology | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 7473161 | ||
3510 | 2240 | 14 | None | 89125 | 3 | Human | 9.9 | pKi | = | 9.9 | Binding | Guide to Pharmacology | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 7473161 | ||
CHEMBL42407 | 2240 | 14 | None | 89125 | 3 | Human | 9.9 | pKi | = | 9.9 | Binding | Guide to Pharmacology | 559 | 11 | 2 | 5 | 4.2 | COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 | 7473161 | ||
2090 | 2726 | 20 | None | -309 | 4 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | None | None | None | None | 9190866 | ||||
5311312 | 2726 | 20 | None | -309 | 4 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | None | None | None | None | 9190866 | ||||
CHEMBL437797 | 2726 | 20 | None | -309 | 4 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | None | None | None | None | 9190866 | ||||
2110 | 2922 | 33 | None | -1258 | 6 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 12206858 | ||
219077 | 2922 | 33 | None | -1258 | 6 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 12206858 | ||
3480 | 2922 | 33 | None | -1258 | 6 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 12206858 | ||
CHEMBL346178 | 2922 | 33 | None | -1258 | 6 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 12206858 | ||
DB04872 | 2922 | 33 | None | -1258 | 6 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 605 | 8 | 0 | 3 | 7.4 | O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 | 12206858 | ||
104974 | 3419 | 27 | None | -1202 | 7 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 12206858 | ||
104974 | 3419 | 27 | None | -1202 | 7 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 9190866 | ||
2111 | 3419 | 27 | None | -1202 | 7 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 12206858 | ||
2111 | 3419 | 27 | None | -1202 | 7 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 9190866 | ||
3481 | 3419 | 27 | None | -1202 | 7 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 12206858 | ||
3481 | 3419 | 27 | None | -1202 | 7 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 9190866 | ||
CHEMBL308148 | 3419 | 27 | None | -1202 | 7 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 12206858 | ||
CHEMBL308148 | 3419 | 27 | None | -1202 | 7 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 9190866 | ||
DB06660 | 3419 | 27 | None | -1202 | 7 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 12206858 | ||
DB06660 | 3419 | 27 | None | -1202 | 7 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 551 | 9 | 1 | 3 | 6.4 | CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 | 9190866 | ||
2105 | 3225 | 0 | None | - | 1 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | None | None | None | None | 12206858 | ||||
2089 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
2089 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 1311270 | ||||
2089 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 8985159 | ||||
2089 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 9190866 | ||||
3795 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
3795 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 1311270 | ||||
3795 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 8985159 | ||||
3795 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 9190866 | ||||
5311311 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
5311311 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 1311270 | ||||
5311311 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 8985159 | ||||
5311311 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 9190866 | ||||
CHEMBL217406 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
CHEMBL217406 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 1311270 | ||||
CHEMBL217406 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 8985159 | ||||
CHEMBL217406 | 2725 | 21 | None | -102 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 9190866 | ||||
2106 | 3490 | 3 | None | -5 | 3 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 711 | 12 | 1 | 6 | 6.4 | CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C | 12206858 | ||
9875034 | 3490 | 3 | None | -5 | 3 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 711 | 12 | 1 | 6 | 6.4 | CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C | 12206858 | ||
CHEMBL77023 | 3490 | 3 | None | -5 | 3 | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 711 | 12 | 1 | 6 | 6.4 | CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C | 12206858 | ||
2098 | 3638 | 31 | None | 1 | 6 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
2098 | 3638 | 31 | None | 1 | 6 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 15265501 | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
36511 | 3638 | 31 | None | 1 | 6 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 15265501 | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
3805 | 3638 | 31 | None | 1 | 6 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 15265501 | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
3835 | 3638 | 31 | None | 1 | 6 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 15265501 | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 11786503 | ||||
CHEMBL235363 | 3638 | 31 | None | 1 | 6 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 15265501 |