The RMSD values compare the latest model before a structure of the same receptor in the same state was published. Documentation


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ROOT-MEAN-SQUARE DEVIATION (Å)
RECEPTOR
EXPERIMENTAL STRUCTURE
MODEL
MAIN TEMPLATE
Overall
all
Overall
backbone
7TM
all
7TM
backbone
H8 ICL1 ECL1 ICL2 ECL2 ECL3
UniProt
IUPHAR Receptor family Cl.
PDB
State Degree
active (%)
Version Note GN seq.
id. (%)
GN seq.
sim. (%)
UniProt
IUPHAR Receptor family Species
PDB
State Degree
active (%)
Resolution
7.1 6.1 4.0 2.8 21.5 5.2 4.0 2.8 8.7 7.3 PE2R4 EP4 Prostanoid A (Rhodopsin) 5YWY Inactive 18 2018-07-17 TM5 modeled incorrectly due to alignment shift in TM5. The orientation of H8 is different in the structure than what was expected 18 37 5HT2C 5-HT2C 5-Hydroxytryptamine Human 6BQH Inactive 1 2.7
8.3 8.0 7.3 7.0 16.3 - 6.6 5.3 8.6 13.2 TA2R TP Prostanoid A (Rhodopsin) 6IIU Intermediate 51 2018-07-17 TM5 modeled incorrectly due to alignment shift in TM5. The orientation of H8 is different in the structure than what was expected 16 35 5HT2C 5-HT2C 5-Hydroxytryptamine Human 6BQH Inactive 1 2.7
3.6 2.5 2.7 1.8 0.4 1.6 3.0 3.5 3.8 - NK1R NK1 Tachykinin A (Rhodopsin) 6HLP Inactive 1 2018-07-17 - 30 50 OX2R OX2 Orexin Human 5WS3 Inactive 1 2.3
3.7 2.9 3.4 2.5 4.7 1.1 - 4.6 3.4 5.9 PTH1R PTH1 Parathyroid hormone B1 (Secretin) 6FJ3 Inactive 0 2018-07-17 - 41 59 GLP1R GLP-1 Glucagon Human 5VEW Inactive 0 2.7
4.4 3.7 2.7 2.1 5.5 2.2 2.9 1.7 10.4 5.5 CNR2 CB2 Cannabinoid A (Rhodopsin) 5ZTY Inactive 6 2019-01-31 - 48 67 CNR1 CB1 Cannabinoid Human 5TGZ Inactive 13 2.8
2.9 2.1 2.3 1.8 0.7 0.5 1.7 6.2 0.9 5.3 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) 6A94 Inactive 1 2019-01-31 - 70 83 5HT2C 5-HT2C 5-Hydroxytryptamine Human 6BQH Inactive 1 2.7
5.5 4.4 3.9 2.6 5.6 3.0 7.6 1.6 9.1 4.9 GPR52 GPR52 A orphans A (Rhodopsin) 6LI0 Intermediate 45 2019-03-14 Target is closer to an intermediate activation state than inactive 21 41 5HT2A 5-HT2A 5-Hydroxytryptamine Human 6A94 Inactive 1 2.9
5.1 4.3 3.0 2.3 2.9 4.6 5.4 1.8 13.3 7.7 MTR1B MT2 Melatonin A (Rhodopsin) 6ME6 Inactive 1 2019-03-14 - 24 47 OX2R OX2 Orexin Human 5WS3 Inactive 1 2.3
6.3 5.8 6.2 5.8 4.5 2.3 - 5.5 8.2 4.2 MC4R MC4 Melanocortin A (Rhodopsin) 6W25 Intermediate 59 2019-03-14 Target is closer to an intermediate activation state than inactive. TM5 modeled incorrectly due to alignment shift in ECL2 and TM5 27 49 S1PR1 S1P1 Lysophospholipid (S1P) Human 3V2Y Inactive 1 2.8
4.7 3.8 3.4 2.5 1.7 3.7 4.4 6.9 9.8 8.3 MTR1A MT1 Melatonin A (Rhodopsin) 6ME2 Inactive 1 2019-03-14 - 25 49 NPY1R Y1 Neuropeptide Y Human 5ZBH Inactive 0 3.0
3.4 2.6 2.7 2.0 2.0 3.8 1.1 6.9 4.7 - CCR7 CCR7 Chemokine A (Rhodopsin) 6QZH Inactive 8 2019-03-14 - 39 62 CCR5 CCR5 Chemokine Human 5UIW Inactive 24 2.2
3.7 2.7 2.5 1.8 0.9 0.8 4.1 4.7 7.2 4.1 ADA2C α2C Adrenoceptors A (Rhodopsin) 6KUW Inactive 1 2019-03-14 - 42 65 DRD2 D2 Dopamine Human 6CM4 Inactive 0 2.9
3.1 2.3 2.6 1.7 1.7 3.1 3.8 4.1 5.7 3.7 ADA2A α2A Adrenoceptors A (Rhodopsin) 6KUX Inactive 1 2019-03-14 - 44 66 DRD2 D2 Dopamine Human 6CM4 Inactive 0 2.9
1.6 1.2 1.4 1.0 1.8 0.8 0.7 2.6 0.9 1.4 ACM5 M5 Acetylcholine (muscarinic) A (Rhodopsin) 6OL9 Inactive 4 2019-03-14 - 80 93 ACM3 M3 Acetylcholine (muscarinic) Rat 4U15 Inactive 4 2.8
3.4 2.4 3.0 1.9 2.1 0.8 3.0 4.2 3.8 - CXCR2 CXCR2 Chemokine A (Rhodopsin) 6LFL Inactive 8 2019-09-02 - 41 63 CCR7 CCR7 Chemokine Human 6QZH Inactive 8 2.1
7.0 6.3 3.2 2.4 - 4.8 6.6 9.5 15.3 2.6 GABR2 GABAB2 GABAB C (Glutamate) 6VJM Inactive 4 2020-07-30 - 20 39 GRM5 mGlu5 Metabotropic glutamate Human 4OO9 Inactive 13 2.6
5.5 4.9 2.8 2.0 - 1.3 11.1 - 10.1 5.4 GABR1 GABAB1 GABAB C (Glutamate) 6W2Y Inactive 0 2020-07-30 - 19 40 GRM5 mGlu5 Metabotropic glutamate Human 4OO9 Inactive 13 2.6
3.5 2.5 3.0 2.3 - - 3.0 2.8 3.4 3.1 OXYR OT Vasopressin and oxytocin A (Rhodopsin) 6TPK Inactive 21 2020-07-30 - 19 39 NK1R NK1 Tachykinin Human 6HLP Inactive 1 2.2
3.9 2.7 3.1 2.1 2.1 4.7 2.9 4.0 3.3 - GHSR ghrelin Ghrelin A (Rhodopsin) 6KO5 Inactive 1 2020-07-30 - 36 54 NTR1 NTS1 Neurotensin Rat 4BUO Inactive 3 2.8
4.6 4.4 3.0 2.3 - - 5.7 - 8.8 4.5 GNRHR GnRH1 Gonadotrophin-releasing hormone A (Rhodopsin) 7BR3 Inactive 21 2020-09-02 - 27 51 OXYR OT Vasopressin and oxytocin Human 6TPK Inactive 21 3.2
5.7 4.9 2.4 1.4 2.3 2.4 17.4 1.5 1.1 - FZD5 FZD5 Frizzled F (Frizzled) 6WW2 Inactive 21 2020-09-02 GPCRdb ECL1 was modeled freely without a template 56 73 FZD4 FZD4 Frizzled Human 6BD4 Inactive 21 2.4