⬤ Gαs ⬤ Gαi/o ⬤ Gαq/11 ⬤ Gα12/13

GPCR selectivity tree. Concentric circles illustrate the G protein-coupling selectivity of each GPCR: the four dots depict both primary and secondary G protein coupling (from inside to outside: s, i/o, q/11, 12/13). Tree nodes can be highlighted and selected to retrieve clade-specific receptor sets, which can be used in dedicated segment specific sequence alignments.


We used the G protein transducer imformation from the GuideToPharmacology (IUPHAR):

Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Sharman JL, Campo B, Cavanagh DR, Alexander SPH, Davenport AP, Spedding M, Davies JA, NC-IUPHAR.
The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY.
Nucleic Acids Research, 2020, 48 (D1 - Database Issue), D1006–D1021. [PMID:31691834]