GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	12455	3050	54	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Activation of full-length human TAS2R16 expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4 dye based FLIPR assayActivation of full-length human TAS2R16 expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4 dye based FLIPR assay	ChEMBL	256	3	4	6	-1.1	C1=CC=C(C=C1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O	nan
	65080	3050	54	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Activation of full-length human TAS2R16 expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4 dye based FLIPR assayActivation of full-length human TAS2R16 expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4 dye based FLIPR assay	ChEMBL	256	3	4	6	-1.1	C1=CC=C(C=C1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O	nan
	CHEMBL4105357	3050	54	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Activation of full-length human TAS2R16 expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4 dye based FLIPR assayActivation of full-length human TAS2R16 expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio by Fluo-4 dye based FLIPR assay	ChEMBL	256	3	4	6	-1.1	C1=CC=C(C=C1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O	nan
	12455	3050	54	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Activation of full-length human TAS2R16 expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio in presence of (E)-4-(2,2,3-trimethylcyclopent-3-enyl)but-2-enoic acid by Fluo-4 dye based FLIPR assayActivation of full-length human TAS2R16 expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio in presence of (E)-4-(2,2,3-trimethylcyclopent-3-enyl)but-2-enoic acid by Fluo-4 dye based FLIPR assay	ChEMBL	256	3	4	6	-1.1	C1=CC=C(C=C1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O	nan
	65080	3050	54	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Activation of full-length human TAS2R16 expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio in presence of (E)-4-(2,2,3-trimethylcyclopent-3-enyl)but-2-enoic acid by Fluo-4 dye based FLIPR assayActivation of full-length human TAS2R16 expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio in presence of (E)-4-(2,2,3-trimethylcyclopent-3-enyl)but-2-enoic acid by Fluo-4 dye based FLIPR assay	ChEMBL	256	3	4	6	-1.1	C1=CC=C(C=C1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O	nan
	CHEMBL4105357	3050	54	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Activation of full-length human TAS2R16 expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio in presence of (E)-4-(2,2,3-trimethylcyclopent-3-enyl)but-2-enoic acid by Fluo-4 dye based FLIPR assayActivation of full-length human TAS2R16 expressed in HEK293T/Galpha16-gustducin 44 cells assessed as effect on calcium flux by measuring deltaF/F0 ratio in presence of (E)-4-(2,2,3-trimethylcyclopent-3-enyl)but-2-enoic acid by Fluo-4 dye based FLIPR assay	ChEMBL	256	3	4	6	-1.1	C1=CC=C(C=C1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O	nan
	1499	2060	43	None	-63	36	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	3779	2060	43	None	-63	36	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	536	2060	43	None	-63	36	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	CHEMBL434	2060	43	None	-63	36	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	DB01064	2060	43	None	-63	36	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	1499	2060	43	None	-63	36	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	3779	2060	43	None	-63	36	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	536	2060	43	None	-63	36	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	CHEMBL434	2060	43	None	-63	36	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	DB01064	2060	43	None	-63	36	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	12451	1287	0	None	-	1	Human	1.7	pEC50	=	1.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	457	7	7	12	-3.1	C1=CC=C(C=C1)C(C#N)OC2C(C(C(C(O2)COC3C(C(C(C(O3)CO)O)O)O)O)O)O	12379855
	2180	1287	0	None	-	1	Human	1.7	pEC50	=	1.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	457	7	7	12	-3.1	C1=CC=C(C=C1)C(C#N)OC2C(C(C(C(O2)COC3C(C(C(C(O3)CO)O)O)O)O)O)O	12379855
	CHEMBL1967951	1287	0	None	-	1	Human	1.7	pEC50	=	1.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	457	7	7	12	-3.1	C1=CC=C(C=C1)C(C#N)OC2C(C(C(C(O2)COC3C(C(C(C(O3)CO)O)O)O)O)O)O	12379855
	12452	608	0	None	-	1	Human	2.4	pEC50	=	2.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	342	4	8	11	-5.4	C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)O)O)O)O)O)O)O)O	20965151
	441422	608	0	None	-	1	Human	2.4	pEC50	=	2.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	342	4	8	11	-5.4	C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)O)O)O)O)O)O)O)O	20965151
	CHEMBL1360334	608	0	None	-	1	Human	2.4	pEC50	=	2.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	342	4	8	11	-5.4	C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)O)O)O)O)O)O)O)O	20965151
	12454	3406	0	None	-	1	Human	2.9	pEC50	=	2.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	286	4	5	7	-1.6	C1=CC=C(C(=C1)CO)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O	12379855
	439503	3406	0	None	-	1	Human	2.9	pEC50	=	2.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	286	4	5	7	-1.6	C1=CC=C(C(=C1)CO)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O	12379855
	12455	3050	54	None	-	1	Human	3.0	pEC50	=	3.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	3	4	6	-1.1	C1=CC=C(C=C1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O	12379855
	65080	3050	54	None	-	1	Human	3.0	pEC50	=	3.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	3	4	6	-1.1	C1=CC=C(C=C1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O	12379855
	CHEMBL4105357	3050	54	None	-	1	Human	3.0	pEC50	=	3.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	256	3	4	6	-1.1	C1=CC=C(C=C1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O	12379855
	12453	123	0	None	-	1	Human	3.2	pEC50	=	3.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	301	4	4	8	-1.2	OC[C@H]1O[C@@H](OC2=CC=C(C=C2)[N+]([O-])=O)[C@@H](O)[C@@H](O)[C@@H]1O	28798468
	161880	123	0	None	-	1	Human	3.2	pEC50	=	3.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	301	4	4	8	-1.2	OC[C@H]1O[C@@H](OC2=CC=C(C=C2)[N+]([O-])=O)[C@@H](O)[C@@H](O)[C@@H]1O	28798468
	CHEMBL4462691	123	0	None	-	1	Human	3.2	pEC50	=	3.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	301	4	4	8	-1.2	OC[C@H]1O[C@@H](OC2=CC=C(C=C2)[N+]([O-])=O)[C@@H](O)[C@@H](O)[C@@H]1O	28798468
	2268	3121	0	None	-1	2	Human	3.5	pIC50	=	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	285	7	1	3	2.2	CCCN(S(=O)(=O)c1ccc(cc1)C(=O)O)CCC	21629661
	4357	3121	0	None	-1	2	Human	3.5	pIC50	=	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	285	7	1	3	2.2	CCCN(S(=O)(=O)c1ccc(cc1)C(=O)O)CCC	21629661
	4911	3121	0	None	-1	2	Human	3.5	pIC50	=	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	285	7	1	3	2.2	CCCN(S(=O)(=O)c1ccc(cc1)C(=O)O)CCC	21629661
	CHEMBL897	3121	0	None	-1	2	Human	3.5	pIC50	=	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	285	7	1	3	2.2	CCCN(S(=O)(=O)c1ccc(cc1)C(=O)O)CCC	21629661
	DB01032	3121	0	None	-1	2	Human	3.5	pIC50	=	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	285	7	1	3	2.2	CCCN(S(=O)(=O)c1ccc(cc1)C(=O)O)CCC	21629661

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)