Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
138107701 186881 39 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
5311181 186881 39 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
CHEMBL494 186881 39 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
138107701 186881 39 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 186881 39 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 186881 39 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
138 3032 84 None -16 9 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
1882 3032 84 None -16 9 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
5280723 3032 84 None -16 9 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
CHEMBL495 3032 84 None -16 9 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
DB00770 3032 84 None -16 9 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
2720 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
5820 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
6918140 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
CHEMBL1237119 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
DB00374 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
118727298 116910 0 None -3 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398219 116910 0 None -3 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
118727308 116920 0 None 1 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398229 116920 0 None 1 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
44235755 153174 0 None 81 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3981509 153174 0 None 81 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727301 116913 0 None -1 3 Human 7.0 pEC50 = 7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398222 116913 0 None -1 3 Human 7.0 pEC50 = 7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
56839344 151519 0 None -3311 8 Human 6.0 pEC50 = 6 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 656 13 2 9 5.1 O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F nan
CHEMBL3967284 151519 0 None -3311 8 Human 6.0 pEC50 = 6 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 656 13 2 9 5.1 O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F nan
137636847 155451 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 554 11 3 7 4.1 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
CHEMBL4061744 155451 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 554 11 3 7 4.1 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
118727293 116905 0 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398214 116905 0 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727305 116917 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398226 116917 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
127052613 139676 0 None -13 6 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 431 7 3 7 3.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
CHEMBL3804978 139676 0 None -13 6 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 431 7 3 7 3.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
118727312 116924 0 None 3 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398233 116924 0 None 3 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
118727307 116919 0 None -1 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398228 116919 0 None -1 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727297 116909 0 None -5 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398218 116909 0 None -5 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
118727296 116908 0 None 13 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398217 116908 0 None 13 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44234782 146739 0 None 51 3 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
CHEMBL3928729 146739 0 None 51 3 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
118727294 116906 0 None -7 3 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398215 116906 0 None -7 3 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
118727306 116918 0 None -5 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398227 116918 0 None -5 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727295 116907 0 None -5 2 Rat 6.9 pEC50 = 6.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398216 116907 0 None -5 2 Rat 6.9 pEC50 = 6.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
44235522 141988 0 None -53 2 Rat 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3890685 141988 0 None -53 2 Rat 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
118727302 116914 0 None -2 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398223 116914 0 None -2 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727309 116921 0 None 2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398230 116921 0 None 2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727296 116908 0 None -13 2 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398217 116908 0 None -13 2 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44236221 147186 0 None -151 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3932106 147186 0 None -151 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
44235044 147052 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3930990 147052 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
44232565 153438 0 None -190 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3983767 153438 0 None -190 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44235044 142331 0 None -28 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3893346 142331 0 None -28 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
118727311 116923 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398232 116923 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
126495507 138849 0 None -154 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 425 5 1 5 5.1 Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3793167 138849 0 None -154 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 425 5 1 5 5.1 Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
118727292 116904 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398213 116904 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727313 116925 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398234 116925 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
44235519 147673 0 None -23 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3935924 147673 0 None -23 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
44232564 144896 0 None 162 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3914174 144896 0 None 162 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727288 116900 0 None -7 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398209 116900 0 None -7 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
44235291 151399 0 None 19 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3966307 151399 0 None 19 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
44233041 144742 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)s1 nan
CHEMBL3912947 144742 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)s1 nan
138107701 186881 39 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 186881 39 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 186881 39 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
44219292 112090 30 None 54 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3301604 112090 30 None 54 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44235522 141988 0 None 53 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 nan
CHEMBL3890685 141988 0 None 53 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 nan
44234781 142004 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3890828 142004 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44233522 142296 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)nc2)CC1 nan
CHEMBL3893059 142296 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)nc2)CC1 nan
44235044 142331 0 None 28 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3893346 142331 0 None 28 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44234027 142397 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 418 8 1 6 4.6 Cc1cnc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
CHEMBL3893909 142397 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 418 8 1 6 4.6 Cc1cnc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
44235289 142527 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3895137 142527 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44232806 142640 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(F)c2)CC1 nan
CHEMBL3896069 142640 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(F)c2)CC1 nan
58172125 142712 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3896580 142712 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 nan
44234528 143039 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3899229 143039 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44234532 143137 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3900038 143137 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44233772 143142 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 425 9 1 4 4.8 CN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL3900091 143142 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 425 9 1 4 4.8 CN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
44234533 143464 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
CHEMBL3902808 143464 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
44233523 143478 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 399 8 1 6 3.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cnccn2)CC1 nan
CHEMBL3902855 143478 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 399 8 1 6 3.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cnccn2)CC1 nan
44235040 144061 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3907754 144061 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44235291 144612 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3912086 144612 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
44232564 144896 0 None 162 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 nan
CHEMBL3914174 144896 0 None 162 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 nan
44236219 144908 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 444 9 2 4 4.6 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1F nan
CHEMBL3914231 144908 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 444 9 2 4 4.6 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1F nan
44234780 144938 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3914443 144938 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44233776 144942 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 428 9 1 6 4.3 COc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3914495 144942 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 428 9 1 6 4.3 COc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44233282 145051 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3915367 145051 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(Cl)c2)CC1 nan
44236220 145273 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
CHEMBL3917017 145273 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
58172129 145309 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3917222 145309 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44233775 145313 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccnc(F)c2)CC1 nan
CHEMBL3917276 145313 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccnc(F)c2)CC1 nan
44234028 145339 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O nan
CHEMBL3917503 145339 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O nan
44236217 145435 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
CHEMBL3918258 145435 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
44219292 145555 30 None 20 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3919269 145555 30 None 20 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44234029 145686 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 488 10 2 5 4.6 O=C(O)CNC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3920236 145686 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 488 10 2 5 4.6 O=C(O)CNC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44232567 145799 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
CHEMBL3921158 145799 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
44235983 145845 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 9 2 3 4.3 CN(C(=O)NC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL3921534 145845 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 9 2 3 4.3 CN(C(=O)NC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
44234032 145905 0 None 22 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
CHEMBL3922000 145905 0 None 22 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
44233042 146002 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
CHEMBL3922686 146002 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
44235289 146136 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3923745 146136 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44233520 146297 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)c1 nan
CHEMBL3924965 146297 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)c1 nan
58172126 146364 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cn2)CC1 nan
CHEMBL3925563 146364 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cn2)CC1 nan
44235521 146423 0 None 67 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
CHEMBL3926078 146423 0 None 67 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
58172128 146468 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccccc1N(C(=O)OC[C@H]1CC[C@@H](COCC(=O)O)CC1)c1ccccc1 nan
CHEMBL3926491 146468 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccccc1N(C(=O)OC[C@H]1CC[C@@H](COCC(=O)O)CC1)c1ccccc1 nan
44233280 146482 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3926604 146482 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(Cl)cc2)CC1 nan
44235984 146731 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccnc2)CC1 nan
CHEMBL3928658 146731 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccnc2)CC1 nan
44234782 146739 0 None 51 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3928729 146739 0 None 51 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44235044 147052 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3930990 147052 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44234284 147161 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cncc(F)c2)CC1 nan
CHEMBL3931899 147161 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cncc(F)c2)CC1 nan
44235290 147322 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 321 7 2 4 3.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)Nc2ccccc2)CC1 nan
CHEMBL3933131 147322 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 321 7 2 4 3.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)Nc2ccccc2)CC1 nan
44234032 147392 0 None 38 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
CHEMBL3933704 147392 0 None 38 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
44232808 147471 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
CHEMBL3934336 147471 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
44234026 147506 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 453 11 1 4 5.5 CCCN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL3934619 147506 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 453 11 1 4 5.5 CCCN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
44235519 147673 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3935924 147673 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
58172127 147680 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 1 5 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cn2)CC1 nan
CHEMBL3935961 147680 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 1 5 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cn2)CC1 nan
44233038 147808 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 443 8 1 4 5.6 Cc1cc(C)cc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
CHEMBL3937089 147808 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 443 8 1 4 5.6 Cc1cc(C)cc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
44233283 147972 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccnc2)CC1 nan
CHEMBL3938313 147972 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccnc2)CC1 nan
44233777 148016 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 412 8 1 5 4.6 Cc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3938716 148016 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 412 8 1 5 4.6 Cc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44232804 148159 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccn2)CC1 nan
CHEMBL3939932 148159 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccn2)CC1 nan
44233518 148296 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)cc1 nan
CHEMBL3941036 148296 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)cc1 nan
44235519 148506 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3942683 148506 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44235043 148545 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 464 8 2 3 5.5 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(C(F)(F)F)c2)CC1 nan
CHEMBL3943011 148545 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 464 8 2 3 5.5 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(C(F)(F)F)c2)CC1 nan
44234530 148573 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 1 3 4.8 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(c1ccccc1)c1ccccc1 nan
CHEMBL3943161 148573 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 1 3 4.8 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(c1ccccc1)c1ccccc1 nan
44232568 148660 0 None 346 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 nan
CHEMBL3943791 148660 0 None 346 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 nan
44234529 148893 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
CHEMBL3945849 148893 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
44234532 149692 0 None 31 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3952237 149692 0 None 31 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44233774 149703 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 441 10 1 5 5.3 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3952293 149703 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 441 10 1 5 5.3 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44233521 149721 0 None 81 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 nan
CHEMBL3952439 149721 0 None 81 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 nan
44235042 149738 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 440 9 2 4 4.8 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c(C)c1 nan
CHEMBL3952569 149738 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 440 9 2 4 4.8 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c(C)c1 nan
44232569 149875 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(Cl)c2)CC1 nan
CHEMBL3953739 149875 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(Cl)c2)CC1 nan
44233279 150136 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 6 3.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cnccn2)CC1 nan
CHEMBL3955699 150136 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 6 3.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cnccn2)CC1 nan
44233039 150363 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
CHEMBL3957516 150363 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
44232805 150396 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cc(F)cc(F)c2)CC1 nan
CHEMBL3957760 150396 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cc(F)cc(F)c2)CC1 nan
44235979 150553 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
CHEMBL3959044 150553 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
44233040 150715 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 434 8 1 5 4.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)nc2)c2cccc(F)c2)CC1 nan
CHEMBL3960203 150715 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 434 8 1 5 4.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)nc2)c2cccc(F)c2)CC1 nan
44233281 150837 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)s1 nan
CHEMBL3961361 150837 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)s1 nan
44235756 150886 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
CHEMBL3961761 150886 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
44233773 150894 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 438 9 1 3 4.7 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(C)C(c1ccccc1)c1ccccc1 nan
CHEMBL3961809 150894 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 438 9 1 3 4.7 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(C)C(c1ccccc1)c1ccccc1 nan
44235041 151227 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3964788 151227 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44235291 151399 0 None 19 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3966307 151399 0 None 19 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
44235039 151405 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(C)c2)c1 nan
CHEMBL3966331 151405 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(C)c2)c1 nan
44236216 151622 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 5 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
CHEMBL3968156 151622 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 5 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
44234783 151697 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(C)cc2)cc1 nan
CHEMBL3968835 151697 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(C)cc2)cc1 nan
44235982 151732 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
CHEMBL3969137 151732 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
44232566 151911 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(Cl)c2)CC1 nan
CHEMBL3970829 151911 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(Cl)c2)CC1 nan
44235520 152425 0 None 89 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
CHEMBL3975122 152425 0 None 89 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
44234528 152452 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3975263 152452 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44234283 152460 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 466 8 1 5 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(C(F)(F)F)cn2)CC1 nan
CHEMBL3975307 152460 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 466 8 1 5 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(C(F)(F)F)cn2)CC1 nan
44232807 152569 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(F)c2)CC1 nan
CHEMBL3976286 152569 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(F)c2)CC1 nan
44233519 152703 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(OC(F)(F)F)cc2)CC1 nan
CHEMBL3977415 152703 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(OC(F)(F)F)cc2)CC1 nan
44236218 152720 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
CHEMBL3977559 152720 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
44234779 152745 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2F)CC1 nan
CHEMBL3977761 152745 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2F)CC1 nan
44235980 152890 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2F)CC1 nan
CHEMBL3979096 152890 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2F)CC1 nan
44233043 153080 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(OC(F)(F)F)c2)CC1 nan
CHEMBL3980758 153080 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(OC(F)(F)F)c2)CC1 nan
44234782 153155 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3981383 153155 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44235981 153171 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
CHEMBL3981484 153171 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
44235755 153174 0 None 81 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
CHEMBL3981509 153174 0 None 81 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
44232803 153260 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 1 4 5.5 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1F nan
CHEMBL3982288 153260 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 1 4 5.5 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1F nan
44233278 153371 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccnc2)c2cccc(F)c2)CC1 nan
CHEMBL3983200 153371 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccnc2)c2cccc(F)c2)CC1 nan
44232565 153438 0 None 95 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 nan
CHEMBL3983767 153438 0 None 95 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 nan
44235754 153464 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
CHEMBL3984010 153464 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
44234278 153486 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 9 3 3 4.0 O=C(O)COC[C@H]1CC[C@H](CNC(=O)NC(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3984207 153486 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 9 3 3 4.0 O=C(O)COC[C@H]1CC[C@H](CNC(=O)NC(c2ccccc2)c2ccccc2)CC1 nan
44235753 153645 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1F nan
CHEMBL3985726 153645 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1F nan
118727297 116909 0 None 1 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398218 116909 0 None 1 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
118727311 116923 0 None 2 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398232 116923 0 None 2 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727315 116927 0 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398236 116927 0 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
5077 3522 72 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
7552 3522 72 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9913767 3522 72 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL238804 3522 72 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
DB11362 3522 72 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
44234532 149692 0 None 31 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952237 149692 0 None 31 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
118727285 116897 0 None -104 3 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398206 116897 0 None -104 3 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
5852 2579 47 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9931891 2579 47 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL239226 2579 47 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
44232568 148660 0 None 346 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3943791 148660 0 None 346 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727293 116905 0 None -2 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398214 116905 0 None -2 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727295 116907 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398216 116907 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
58172125 142712 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3896580 142712 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
44304181 201582 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
CHEMBL64663 201582 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
127052614 139696 0 None -645 6 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 415 7 2 6 4.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
CHEMBL3805176 139696 0 None -645 6 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 415 7 2 6 4.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
118727310 116922 0 None 3 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398231 116922 0 None 3 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727301 116913 0 None -1 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398222 116913 0 None -1 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727304 116916 0 None -3 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398225 116916 0 None -3 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
5283086 201619 19 None -1258 4 Human 6.6 pEC50 = 6.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/s0960-894x(01)00359-6
CHEMBL64804 201619 19 None -1258 4 Human 6.6 pEC50 = 6.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/s0960-894x(01)00359-6
118727314 116926 0 None -6 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398235 116926 0 None -6 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727286 116898 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398207 116898 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
44235291 151399 0 None -19 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3966307 151399 0 None -19 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
44232568 148660 0 None -346 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3943791 148660 0 None -346 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727299 116911 0 None -2 3 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398220 116911 0 None -2 3 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
44234032 147392 0 None -38 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147392 0 None -38 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
56839536 142637 0 None -16 7 Human 6.5 pEC50 = 6.5 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 604 15 2 7 5.1 CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 nan
CHEMBL3896035 142637 0 None -16 7 Human 6.5 pEC50 = 6.5 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 604 15 2 7 5.1 CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 nan
44235044 142331 0 None 28 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3893346 142331 0 None 28 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
44235521 146423 0 None 67 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3926078 146423 0 None 67 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44235519 147673 0 None 23 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3935924 147673 0 None 23 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
118727287 116899 0 None -18 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398208 116899 0 None -18 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
44232564 144896 0 None -446 3 Rat 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3914174 144896 0 None -446 3 Rat 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727314 116926 0 None -1 3 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398235 116926 0 None -1 3 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
1883 3033 71 None -54 10 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
1916 3033 71 None -54 10 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
5280360 3033 71 None -54 10 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
913 3033 71 None -54 10 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
CHEMBL548 3033 71 None -54 10 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
DB00917 3033 71 None -54 10 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
118727291 116903 0 None -57 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398212 116903 0 None -57 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
118727290 116902 0 None -6 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398211 116902 0 None -6 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44234532 149692 0 None -32 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952237 149692 0 None -32 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
118727291 116903 0 None -6 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398212 116903 0 None -6 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
44303980 167511 0 None -1 2 Human 7.4 pEC50 = 7.4 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 408 13 2 5 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1016/s0960-894x(01)00359-6
CHEMBL432522 167511 0 None -1 2 Human 7.4 pEC50 = 7.4 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 408 13 2 5 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1016/s0960-894x(01)00359-6
118727288 116900 0 None -14 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398209 116900 0 None -14 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727309 116921 0 None -2 2 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398230 116921 0 None -2 2 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727307 116919 0 None 1 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398228 116919 0 None 1 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44235522 141988 0 None 53 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3890685 141988 0 None 53 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
118727289 116901 0 None -8 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398210 116901 0 None -8 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727312 116924 0 None -3 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398233 116924 0 None -3 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
118727308 116920 0 None -1 3 Rat 7.4 pEC50 = 7.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398229 116920 0 None -1 3 Rat 7.4 pEC50 = 7.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
44235521 146423 0 None -67 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3926078 146423 0 None -67 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44233521 149721 0 None 81 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952439 149721 0 None 81 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
118727303 116915 0 None -4 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398224 116915 0 None -4 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727306 116918 0 None -13 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398227 116918 0 None -13 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44219292 145555 30 None 20 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 145555 30 None 20 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
69753740 139692 0 None -12 5 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 390 9 3 5 2.8 O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.5b00455
CHEMBL3805134 139692 0 None -12 5 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 390 9 3 5 2.8 O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.5b00455
44234782 146739 0 None -51 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
CHEMBL3928729 146739 0 None -51 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
44234532 143137 0 None -23 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3900038 143137 0 None -23 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
118352160 138899 0 None -7079 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 423 5 2 6 4.1 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3793892 138899 0 None -7079 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 423 5 2 6 4.1 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
44236221 147186 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
CHEMBL3932106 147186 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
44236221 147186 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3932106 147186 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
118727298 116910 0 None -16 3 Rat 7.3 pEC50 = 7.3 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398219 116910 0 None -16 3 Rat 7.3 pEC50 = 7.3 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
44219292 112090 30 None -54 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112090 30 None -54 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
118352285 138939 0 None -2398 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 406 5 2 5 4.2 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3794226 138939 0 None -2398 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 406 5 2 5 4.2 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
44235520 152425 0 None -89 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3975122 152425 0 None -89 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
44234532 143137 0 None 23 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3900038 143137 0 None 23 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
56649302 152134 0 None -14 6 Human 6.3 pEC50 = 6.3 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 630 13 2 7 5.5 O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
CHEMBL3972583 152134 0 None -14 6 Human 6.3 pEC50 = 6.3 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 630 13 2 7 5.5 O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
44235520 146740 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
CHEMBL3928737 146740 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
44219292 145555 30 None -20 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 145555 30 None -20 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
44234032 145905 0 None -22 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3922000 145905 0 None -22 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727315 116927 0 None 4 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398236 116927 0 None 4 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
5077 3522 72 None 1 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
7552 3522 72 None 1 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9913767 3522 72 None 1 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL238804 3522 72 None 1 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
DB11362 3522 72 None 1 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
44235520 152425 0 None 89 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3975122 152425 0 None 89 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
118727287 116899 0 None -3 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398208 116899 0 None -3 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727290 116902 0 None 1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398211 116902 0 None 1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727303 116915 0 None -1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398224 116915 0 None -1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44234531 150885 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3961754 150885 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
118727300 116912 0 None -2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398221 116912 0 None -2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
44234032 145905 0 None 22 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3922000 145905 0 None 22 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727300 116912 0 None -25 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398221 116912 0 None -25 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
44235755 153174 0 None -81 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3981509 153174 0 None -81 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727302 116914 0 None -14 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398223 116914 0 None -14 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
44232565 153438 0 None 95 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3983767 153438 0 None 95 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727316 116928 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398237 116928 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
118727310 116922 0 None -3 2 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398231 116922 0 None -3 2 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
127029402 138828 0 None -524 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 407 5 2 6 3.6 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3793009 138828 0 None -524 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 407 5 2 6 3.6 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
118727294 116906 0 None -5 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398215 116906 0 None -5 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
44219292 112090 30 None 54 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112090 30 None 54 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
44234032 147392 0 None 38 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147392 0 None 38 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727313 116925 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398234 116925 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
118727304 116916 0 None 3 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398225 116916 0 None 3 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
56839342 148475 0 None -85 7 Human 6.1 pEC50 = 6.1 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 646 13 2 7 6.0 O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
CHEMBL3942394 148475 0 None -85 7 Human 6.1 pEC50 = 6.1 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 646 13 2 7 6.0 O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
118727299 116911 0 None 1 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398220 116911 0 None 1 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
118727289 116901 0 None -20 3 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398210 116901 0 None -20 3 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44234028 145339 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
CHEMBL3917503 145339 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
56839343 143747 0 None -257 6 Human 5.0 pEC50 = 5.0 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 642 14 2 8 5.4 COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 nan
CHEMBL3904989 143747 0 None -257 6 Human 5.0 pEC50 = 5.0 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 642 14 2 8 5.4 COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 nan
118727285 116897 0 None -46 3 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398206 116897 0 None -46 3 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
24901445 86818 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232964 86818 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
44416266 14531 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1206115 14531 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL212943 14531 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
44416264 14687 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207438 14687 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL405770 14687 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10028418 14503 3 None -19 2 Rat 5.9 pIC50 = 5.9 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205677 14503 3 None -19 2 Rat 5.9 pIC50 = 5.9 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132589 14503 3 None -19 2 Rat 5.9 pIC50 = 5.9 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
24901438 86274 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231746 86274 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10694649 13456 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 445 10 2 4 6.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NC(=O)c1ccc(/N=N/c2ccccc2)cc1 10.1021/jm970343g
CHEMBL119397 13456 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 445 10 2 4 6.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NC(=O)c1ccc(/N=N/c2ccccc2)cc1 10.1021/jm970343g
10671942 103739 0 None -16 3 Human 5.8 pIC50 = 5.8 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 467 9 2 4 5.5 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3ccccc3c2c1 10.1021/jm970343g
CHEMBL309835 103739 0 None -16 3 Human 5.8 pIC50 = 5.8 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 467 9 2 4 5.5 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3ccccc3c2c1 10.1021/jm970343g
16664733 154289 0 None 275 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400404 154289 0 None 275 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
24901440 86561 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232362 86561 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901439 86359 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232156 86359 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901443 86775 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232767 86775 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10717385 167947 0 None -25703 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)[C@H]2CC[C@@H]1C2 10.1021/jm970343g
CHEMBL435382 167947 0 None -25703 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)[C@H]2CC[C@@H]1C2 10.1021/jm970343g
24901449 153064 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
CHEMBL398063 153064 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
24901451 153898 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL399000 153898 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
10529683 163092 0 None -4 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 509 11 2 5 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NS(=O)(=O)c3ccc(/N=N/c4ccccc4)cc3)[C@@H]1C2 10.1021/jm970343g
CHEMBL420404 163092 0 None -4 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 509 11 2 5 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NS(=O)(=O)c3ccc(/N=N/c4ccccc4)cc3)[C@@H]1C2 10.1021/jm970343g
24901441 145564 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL391933 145564 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44432434 86259 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231709 86259 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
44416281 14532 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1206120 14532 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL215442 14532 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10553794 163086 0 None -14 2 Human 5.4 pIC50 = 5.4 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 512 10 2 6 5.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3cc([N+](=O)[O-])ccc3c2c1 10.1021/jm970343g
CHEMBL420398 163086 0 None -14 2 Human 5.4 pIC50 = 5.4 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 512 10 2 6 5.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3cc([N+](=O)[O-])ccc3c2c1 10.1021/jm970343g
24901447 86871 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL233170 86871 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10139047 12724 0 None 14 2 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1188479 12724 0 None 14 2 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL439357 12724 0 None 14 2 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10623568 203617 0 None -9 3 Human 5.3 pIC50 = 5.3 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 453 10 2 3 5.2 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm970343g
CHEMBL79511 203617 0 None -9 3 Human 5.3 pIC50 = 5.3 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 453 10 2 3 5.2 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm970343g
24901442 86612 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232578 86612 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44416279 14649 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207258 14649 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL379203 14649 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
9825740 14504 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 7.0 O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205678 14504 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 7.0 O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132649 14504 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 7.0 O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 10.1016/j.bmcl.2006.06.076
44416294 14715 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207781 14715 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL438092 14715 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10601359 103821 0 None -151 2 Human 5.2 pIC50 = 5.2 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 497 10 2 5 5.5 COc1cc2c(cc1S(=O)(=O)N[C@@H]1[C@@H]3CC[C@@H](C3)[C@H]1C/C=C\CCCC(=O)O)oc1ccccc12 10.1021/jm970343g
CHEMBL309987 103821 0 None -151 2 Human 5.2 pIC50 = 5.2 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 497 10 2 5 5.5 COc1cc2c(cc1S(=O)(=O)N[C@@H]1[C@@H]3CC[C@@H](C3)[C@H]1C/C=C\CCCC(=O)O)oc1ccccc12 10.1021/jm970343g
10028418 14503 3 None 19 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205677 14503 3 None 19 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132589 14503 3 None 19 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
24901437 87632 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL234598 87632 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10139047 12724 0 None -14 2 Rat 6.2 pIC50 = 6.2 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1188479 12724 0 None -14 2 Rat 6.2 pIC50 = 6.2 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL439357 12724 0 None -14 2 Rat 6.2 pIC50 = 6.2 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
24901446 154290 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400405 154290 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10813802 13677 0 None -91 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 459 8 2 3 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3ccc4oc5ccccc5c4c3)[C@@H]1C2 10.1021/jm970343g
CHEMBL119550 13677 0 None -91 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 459 8 2 3 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3ccc4oc5ccccc5c4c3)[C@@H]1C2 10.1021/jm970343g
24901448 86514 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232330 86514 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901444 86776 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232768 86776 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
10502610 163166 0 None -13 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2ccccc2c1 10.1021/jm970343g
CHEMBL420507 163166 0 None -13 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2ccccc2c1 10.1021/jm970343g
19358473 14654 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 461 8 1 4 6.7 O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207287 14654 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 461 8 1 4 6.7 O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL386580 14654 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 461 8 1 4 6.7 O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
44377464 119580 0 None - 0 Human 4.5 pKi = 4.5 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl 10.1016/s0960-894x(01)00056-7
CHEMBL350832 119580 0 None - 0 Human 4.5 pKi = 4.5 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl 10.1016/s0960-894x(01)00056-7
10402929 57239 0 None - 0 Human 4.4 pKi = 4.4 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00056-7
CHEMBL166351 57239 0 None - 0 Human 4.4 pKi = 4.4 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00056-7
10204312 3296 0 None - 1 Human 8.5 pA2 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
4042 3296 0 None - 1 Human 8.5 pA2 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
1969 798 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
1969 798 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 21549696
9839644 798 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
9839644 798 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 21549696
CHEMBL9540 798 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
CHEMBL9540 798 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 21549696
138 3032 84 None -16 9 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3032 84 None -16 9 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3032 84 None -16 9 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3032 84 None -16 9 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3032 84 None -16 9 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
138107701 186881 39 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 186881 39 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 186881 39 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
2720 3793 55 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
5820 3793 55 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
6918140 3793 55 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
CHEMBL1237119 3793 55 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
DB00374 3793 55 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
138107701 186881 39 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 186881 39 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 186881 39 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
2720 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
2720 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
5820 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
5820 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
6918140 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
6918140 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
CHEMBL1237119 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
CHEMBL1237119 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
DB00374 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
DB00374 3793 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
11743147 580 0 None - 1 Human 10.0 pIC50 < 10 Functional
UnclassifiedUnclassified
Guide to Pharmacology 425 9 2 5 4.8 OC(=O)[C@@H](Nc1ncnc(c1)c1ccc(cc1)OCc1ccccc1)Cc1ccccc1 18603238
5851 580 0 None - 1 Human 10.0 pIC50 < 10 Functional
UnclassifiedUnclassified
Guide to Pharmacology 425 9 2 5 4.8 OC(=O)[C@@H](Nc1ncnc(c1)c1ccc(cc1)OCc1ccccc1)Cc1ccccc1 18603238
1883 3033 71 None -54 10 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 3033 71 None -54 10 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 3033 71 None -54 10 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 3033 71 None -54 10 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 3033 71 None -54 10 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 3033 71 None -54 10 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
69658829 215961 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 398 8 3 4 3.3 CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC3=C(C=CC=C3CCCC(O)=O)[C@H]12 None
5853 1538 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 443 11 1 3 6.8 OC(=O)CCC/C=C\C[C@@H]1[C@@H]2CC[C@H]([C@H]1/C=N/OC(c1ccccc1)c1ccccc1)C=C2 3026540
73755162 1538 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 443 11 1 3 6.8 OC(=O)CCC/C=C\C[C@@H]1[C@@H]2CC[C@H]([C@H]1/C=N/OC(c1ccccc1)c1ccccc1)C=C2 3026540
127861 687 0 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 7 1 6 5.8 OC(=O)COc1cccc(c1)c1ocnc1c1nc(c(o1)c1ccccc1)c1ccccc1 9156364
1963 687 0 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 7 1 6 5.8 OC(=O)COc1cccc(c1)c1ocnc1c1nc(c(o1)c1ccccc1)c1ccccc1 9156364
CHEMBL125569 687 0 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 7 1 6 5.8 OC(=O)COc1cccc(c1)c1ocnc1c1nc(c(o1)c1ccccc1)c1ccccc1 9156364
1962 302 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 10 3 4 3.7 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C(F)(F)/C(=C/CCCC(=O)O)/O2)O 9112287
5311226 302 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 10 3 4 3.7 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C(F)(F)/C(=C/CCCC(=O)O)/O2)O 9112287
1968 3697 0 None - 1 Human 6.9 pIC50 None 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 9156364
5311243 3697 0 None - 1 Human 6.9 pIC50 None 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 9156364
CHEMBL2104890 3697 0 None - 1 Human 6.9 pIC50 None 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 9156364
1965 3715 0 None - 1 Human 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 12 3 3 4.7 CCCC[C@@H](C[C@@H](/C=C/[C@H]1[C@H](O)CC2C1CC(=C2)CCCCC(=O)O)O)C 9156364
73755022 3715 0 None - 1 Human 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 12 3 3 4.7 CCCC[C@@H](C[C@@H](/C=C/[C@H]1[C@H](O)CC2C1CC(=C2)CCCCC(=O)O)O)C 9156364
1987175 3735 24 None -1 5 Human 6.7 pKB = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F 23914286
9283 3735 24 None -1 5 Human 6.7 pKB = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F 23914286
CHEMBL1372836 3735 24 None -1 5 Human 6.7 pKB = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F 23914286
10204312 3296 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 19880449
10204312 3296 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 21173040
4042 3296 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 19880449
4042 3296 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 21173040


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
9955130 9414 0 None - 0 Human 8.0 pIC50 = 8 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 9 2 4 5.2 O=C(O)COc1cccc2c1CCCC2CCC(=O)NN(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL11211 9414 0 None - 0 Human 8.0 pIC50 = 8 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 9 2 4 5.2 O=C(O)COc1cccc2c1CCCC2CCC(=O)NN(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
138107701 186881 39 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
5311181 186881 39 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
CHEMBL494 186881 39 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
138107701 186881 39 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
5311181 186881 39 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
CHEMBL494 186881 39 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
127029421 138790 0 None - 0 Human 6.0 pIC50 = 6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 424 10 1 4 3.9 CCCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3792615 138790 0 None - 0 Human 6.0 pIC50 = 6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 424 10 1 4 3.9 CCCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
86277844 111434 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of prostanoid IP receptor (unknown origin)Inhibition of prostanoid IP receptor (unknown origin)
ChEMBL 512 6 2 3 7.5 CCc1ccccc1NC(=O)N1C[C@@H](C)Oc2cc(-c3ccc([C@H]4CC[C@H](CC(=O)O)CC4)cc3)ccc21 10.1021/ml400527n
CHEMBL3287898 111434 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of prostanoid IP receptor (unknown origin)Inhibition of prostanoid IP receptor (unknown origin)
ChEMBL 512 6 2 3 7.5 CCc1ccccc1NC(=O)N1C[C@@H](C)Oc2cc(-c3ccc([C@H]4CC[C@H](CC(=O)O)CC4)cc3)ccc21 10.1021/ml400527n
44235520 152425 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3975122 152425 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
24901449 153064 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
CHEMBL398063 153064 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
24901439 86359 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232156 86359 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44432434 86259 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231709 86259 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
155544367 172802 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Antagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 508 3 0 4 6.0 CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC 10.1021/acs.jmedchem.9b01924
CHEMBL4527708 172802 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Antagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 508 3 0 4 6.0 CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC 10.1021/acs.jmedchem.9b01924
58602756 138901 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 466 8 1 5 4.3 O=C(O)COc1cccc2c1OCCN2CCN(C(=O)c1ccccc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793903 138901 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 466 8 1 5 4.3 O=C(O)COc1cccc2c1OCCN2CCN(C(=O)c1ccccc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2016.03.009
138107701 186881 39 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
5311181 186881 39 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
CHEMBL494 186881 39 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
127029417 138905 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793911 138905 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
138 3032 84 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
1882 3032 84 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
5280723 3032 84 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
CHEMBL495 3032 84 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
DB00770 3032 84 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
44235522 141988 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3890685 141988 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
11296282 1382 22 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 590 6 1 5 7.3 Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C 10.1021/jm9005912
5822 1382 22 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 590 6 1 5 7.3 Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C 10.1021/jm9005912
CHEMBL565591 1382 22 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 590 6 1 5 7.3 Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C 10.1021/jm9005912
9847589 96762 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 471 11 1 4 6.6 CCC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL268477 96762 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 471 11 1 4 6.6 CCC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
10095633 161681 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 457 10 1 4 6.2 CC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL416334 161681 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 457 10 1 4 6.2 CC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
131814 12287 11 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 452 12 1 3 7.7 O=C(O)CCCCCCCCn1nc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
CHEMBL118567 12287 11 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 452 12 1 3 7.7 O=C(O)CCCCCCCCn1nc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
10090048 168850 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 362 10 1 3 5.6 O=C(O)CCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
CHEMBL442405 168850 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 362 10 1 3 5.6 O=C(O)CCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
44219292 145555 30 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 145555 30 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
138107701 186881 39 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
5311181 186881 39 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
CHEMBL494 186881 39 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
44234032 147392 0 None 7 6 Human 7.8 pIC50 = 7.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147392 0 None 7 6 Human 7.8 pIC50 = 7.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
15236833 10916 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 466 9 1 4 6.0 O=C(O)COc1cccc2c1CCCC2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
CHEMBL11746 10916 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 466 9 1 4 6.0 O=C(O)COc1cccc2c1CCCC2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
44157014 192017 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 518 6 1 5 5.9 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL521609 192017 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 518 6 1 5 5.9 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21 10.1016/j.bmcl.2008.12.112
44235755 153174 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3981509 153174 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727303 116915 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398224 116915 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
23355418 6623 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 8 2 4 4.5 O=C(O)COc1cccc2c1CCC(CC(=O)NN(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
CHEMBL10836 6623 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 8 2 4 4.5 O=C(O)COc1cccc2c1CCC(CC(=O)NN(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
44267380 9885 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 464 9 1 4 5.9 O=C(O)COc1cccc2c1CCC=C2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
CHEMBL11480 9885 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 464 9 1 4 5.9 O=C(O)COc1cccc2c1CCC=C2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
127028521 138942 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 423 9 1 3 5.1 O=C(O)COc1ccc(CCCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3794245 138942 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 423 9 1 3 5.1 O=C(O)COc1ccc(CCCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
9823958 9580 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCCC2CCON=C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL11291 9580 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCCC2CCON=C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
44267033 6466 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 485 12 1 4 7.3 CCC/C(CCC1CCCc2c(OCC(=O)O)cccc21)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL10829 6466 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 485 12 1 4 7.3 CCC/C(CCC1CCCc2c(OCC(=O)O)cccc21)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44235044 142331 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3893346 142331 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
118727306 116918 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398227 116918 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44267032 96714 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL268051 96714 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44267058 162668 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL418338 162668 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44235521 146423 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3926078 146423 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44234782 146739 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
CHEMBL3928729 146739 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
118727311 116923 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398232 116923 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
127029147 138980 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 402 8 1 4 3.2 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 10.1016/j.bmcl.2016.03.009
CHEMBL3793541 138980 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 402 8 1 4 3.2 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 10.1016/j.bmcl.2016.03.009
CHEMBL3794662 138980 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 402 8 1 4 3.2 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 10.1016/j.bmcl.2016.03.009
44266708 4714 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 320 12 2 3 4.0 CCCCCC(O)/C=C/CCCc1cccc(OCC(=O)O)c1 10.1016/0960-894X(95)00167-R
CHEMBL10404 4714 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 320 12 2 3 4.0 CCCCCC(O)/C=C/CCCc1cccc(OCC(=O)O)c1 10.1016/0960-894X(95)00167-R
44267244 162153 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 415 8 1 4 4.7 O=C(O)COc1cccc2c1CCC(CON=C(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
CHEMBL417069 162153 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 415 8 1 4 4.7 O=C(O)COc1cccc2c1CCC(CON=C(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
44234532 149692 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952237 149692 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
1892 736 15 None -104 9 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
25886893 736 15 None -104 9 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
CHEMBL1628262 736 15 None -104 9 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
1883 3033 71 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
1916 3033 71 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
5280360 3033 71 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
913 3033 71 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
CHEMBL548 3033 71 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
DB00917 3033 71 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
138107701 186881 39 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
5311181 186881 39 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
CHEMBL494 186881 39 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
138107701 186881 39 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
5311181 186881 39 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
CHEMBL494 186881 39 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
5852 2579 47 None 10 4 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9931891 2579 47 None 10 4 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL239226 2579 47 None 10 4 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
118727316 116928 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398237 116928 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
44232565 153438 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3983767 153438 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
10477568 4809 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C\CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10442 4809 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C\CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
10477567 7117 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C/CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10856 7117 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C/CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
127028838 138959 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 413 7 1 3 5.0 O=C(O)COC1CCC(=CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
CHEMBL3794451 138959 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 413 7 1 3 5.0 O=C(O)COC1CCC(=CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
127029416 138891 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 382 8 1 4 2.9 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2016.03.009
CHEMBL3793824 138891 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 382 8 1 4 2.9 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2016.03.009
118727301 116913 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398222 116913 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727312 116924 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398233 116924 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
44159772 68050 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 535 9 1 4 6.8 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccc(Cl)cc1 10.1016/j.bmcl.2011.01.024
CHEMBL1916708 68050 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 535 9 1 4 6.8 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccc(Cl)cc1 10.1016/j.bmcl.2011.01.024
24901441 145564 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL391933 145564 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901451 153898 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL399000 153898 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
24901448 86514 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232330 86514 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10090958 10549 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1cc(-c2ccccc2)c(-c2ccccc2)n1 10.1021/jm00080a028
CHEMBL117038 10549 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1cc(-c2ccccc2)c(-c2ccccc2)n1 10.1021/jm00080a028
5311035 97354 27 None -91 9 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1021/jm401431x
CHEMBL271896 97354 27 None -91 9 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1021/jm401431x
44219292 112090 30 None 25 7 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112090 30 None 25 7 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
15290482 9192 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL11088 9192 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44235519 147673 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3935924 147673 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
15428700 4514 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 403 11 1 4 5.3 O=C(O)COc1cccc(CCC/C=N/OC(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00167-R
CHEMBL10261 4514 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 403 11 1 4 5.3 O=C(O)COc1cccc(CCC/C=N/OC(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00167-R
9955518 10940 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 452 8 1 4 5.3 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)C2 10.1016/0960-894X(95)00170-X
CHEMBL11765 10940 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 452 8 1 4 5.3 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)C2 10.1016/0960-894X(95)00170-X
44565193 176286 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 520 6 1 5 5.6 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(F)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL461390 176286 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 520 6 1 5 5.6 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(F)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
44267245 10039 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 11 1 3 6.5 O=C(O)COc1cccc2c1CCCC2CCCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL11571 10039 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 11 1 3 6.5 O=C(O)COc1cccc2c1CCCC2CCCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
24901444 86776 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232768 86776 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
44236221 147186 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3932106 147186 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
127029420 138843 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 410 9 1 4 3.5 CCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793117 138843 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 410 9 1 4 3.5 CCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
127028839 138857 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 416 8 1 4 3.6 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
CHEMBL3793265 138857 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 416 8 1 4 3.6 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
44267196 96560 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 10 1 3 6.2 O=C(O)COc1cccc2c1CCCC2CCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL266622 96560 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 10 1 3 6.2 O=C(O)COc1cccc2c1CCCC2CCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
24901447 86871 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL233170 86871 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
16664733 154289 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400404 154289 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
44266736 5048 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 366 8 2 3 3.8 O=C(O)COc1cccc2c1CCC(C/C=C/C(O)Cc1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10564 5048 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 366 8 2 3 3.8 O=C(O)COc1cccc2c1CCC(C/C=C/C(O)Cc1ccccc1)C2 10.1016/0960-894X(95)00167-R
24901446 154290 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400405 154290 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901442 86612 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232578 86612 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
15290515 7053 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 367 8 1 4 4.2 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OCc1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL10853 7053 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 367 8 1 4 4.2 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OCc1ccccc1 10.1016/0960-894X(95)00168-S
44266758 97958 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 350 8 1 2 4.8 O=C(O)COc1cccc2c1CCC(C/C=C/CCc1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL275493 97958 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 350 8 1 2 4.8 O=C(O)COc1cccc2c1CCC(C/C=C/CCc1ccccc1)C2 10.1016/0960-894X(95)00167-R
44234532 143137 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3900038 143137 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
44235291 151399 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3966307 151399 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
24901437 87632 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL234598 87632 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44159530 68042 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 501 9 1 4 6.2 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccccc1 10.1016/j.bmcl.2011.01.024
CHEMBL1916700 68042 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 501 9 1 4 6.2 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccccc1 10.1016/j.bmcl.2011.01.024
11462174 3760 85 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
9277 3760 85 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
CHEMBL560993 3760 85 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
DB11900 3760 85 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
44627395 195197 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 563 7 1 7 5.6 O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1 10.1021/jm9005912
CHEMBL565992 195197 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 563 7 1 7 5.6 O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1 10.1021/jm9005912
44266768 4863 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL10470 4863 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44266768 4863 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00167-R
CHEMBL10470 4863 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00167-R
5077 3522 72 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
7552 3522 72 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9913767 3522 72 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL238804 3522 72 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
DB11362 3522 72 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
118727314 116926 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398235 116926 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727315 116927 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398236 116927 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44190762 176306 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of prostanoid IP receptorInhibition of prostanoid IP receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
CHEMBL461571 176306 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of prostanoid IP receptorInhibition of prostanoid IP receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
118727308 116920 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398229 116920 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
10320441 5375 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00168-S
CHEMBL10742 5375 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00168-S
10320441 5375 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10742 5375 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
10452166 18780 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
CHEMBL128747 18780 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
24901440 86561 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232362 86561 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901438 86274 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231746 86274 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
127028837 138862 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 409 8 1 3 4.7 O=C(O)COc1ccc(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793336 138862 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 409 8 1 3 4.7 O=C(O)COc1ccc(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
24901445 86818 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232964 86818 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901436 87584 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL234391 87584 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44266710 5372 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 346 10 2 3 4.1 CCCCCC(O)/C=C/CC1CCc2c(cccc2OCC(=O)O)C1 10.1016/0960-894X(95)00167-R
CHEMBL10740 5372 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 346 10 2 3 4.1 CCCCCC(O)/C=C/CC1CCc2c(cccc2OCC(=O)O)C1 10.1016/0960-894X(95)00167-R
10321522 167070 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 450 8 1 4 5.6 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)=C2 10.1016/0960-894X(95)00170-X
CHEMBL430154 167070 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 450 8 1 4 5.6 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)=C2 10.1016/0960-894X(95)00170-X
138107701 186881 39 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
5311181 186881 39 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
CHEMBL494 186881 39 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
15290495 97785 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 416 9 1 3 5.5 O=C(O)COc1cccc2c1CCC(CCOC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
CHEMBL274393 97785 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 416 9 1 3 5.5 O=C(O)COc1cccc2c1CCC(CCOC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
9934864 205812 7 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregationAgonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/j.ejmech.2016.07.061
CHEMBL94751 205812 7 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregationAgonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/j.ejmech.2016.07.061
9934864 205812 7 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregationAgonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1007/s00044-012-0261-1
CHEMBL94751 205812 7 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregationAgonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1007/s00044-012-0261-1
118727307 116919 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398228 116919 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44627515 195162 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 572 6 1 5 7.2 Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12 10.1021/jm9005912
CHEMBL565799 195162 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 572 6 1 5 7.2 Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12 10.1021/jm9005912
138107701 186881 39 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 186881 39 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 186881 39 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
127029418 138864 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 412 9 1 5 2.9 COc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793345 138864 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 412 9 1 5 2.9 COc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
24901443 86775 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232767 86775 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44234032 145905 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3922000 145905 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44266775 4806 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 11 2 3 4.8 CCCCCC(O)/C=C/CCC1CCCc2c(OCC(=O)O)cccc21 10.1016/0960-894X(95)00167-R
CHEMBL10439 4806 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 11 2 3 4.8 CCCCCC(O)/C=C/CCC1CCCc2c(OCC(=O)O)cccc21 10.1016/0960-894X(95)00167-R
138107701 186881 39 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 186881 39 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 186881 39 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
11414893 205328 4 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 3 2 4 3.5 Cc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9172 205328 4 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 3 2 4 3.5 Cc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11230941 206602 1 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 3 2 4 2.7 COc1ccc(-c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9936 206602 1 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 3 2 4 2.7 COc1ccc(-c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
10185382 64084 0 None -100 5 Human 6.0 pKi = 6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813119 64084 0 None -100 5 Human 6.0 pKi = 6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
1932 2897 4 None -5888 6 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 410 12 3 3 4.8 C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O 10.1021/jm401431x
5311228 2897 4 None -5888 6 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 410 12 3 3 4.8 C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O 10.1021/jm401431x
CHEMBL3286796 2897 4 None -5888 6 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 410 12 3 3 4.8 C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O 10.1021/jm401431x
9807448 201482 0 None -6309 4 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 398 11 3 3 4.7 CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1 10.1021/jm401431x
CHEMBL64246 201482 0 None -6309 4 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 398 11 3 3 4.7 CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1 10.1021/jm401431x
11771014 205624 4 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 5 0 3 4.4 COc1ccc(Sc2ccc(CN3CCCC3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9367 205624 4 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 5 0 3 4.4 COc1ccc(Sc2ccc(CN3CCCC3)cc2)cc1 10.1016/j.bmcl.2003.10.070
56681885 64088 0 None -28 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
CHEMBL1813122 64088 0 None -28 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
44402824 70777 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 463 7 3 6 3.8 O=C(O)COc1cccc2c1CC[C@](O)(COC(=O)N(c1ccccc1)c1ccccc1)[C@@H]2O 10.1016/j.bmcl.2005.04.047
CHEMBL195456 70777 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 463 7 3 6 3.8 O=C(O)COc1cccc2c1CC[C@](O)(COC(=O)N(c1ccccc1)c1ccccc1)[C@@H]2O 10.1016/j.bmcl.2005.04.047
10277744 64081 0 None -38 7 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813116 64081 0 None -38 7 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
10185103 14524 2 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.042
CHEMBL1206056 14524 2 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.042
CHEMBL190497 14524 2 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.042
10185103 14524 2 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.047
CHEMBL1206056 14524 2 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.047
CHEMBL190497 14524 2 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.047
11461588 4204 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NCCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10058 4204 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NCCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11402676 206633 6 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 258 4 2 3 3.1 COc1ccc(Sc2ccc(C(=N)N)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9953 206633 6 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 258 4 2 3 3.1 COc1ccc(Sc2ccc(C(=N)N)cc2)cc1 10.1016/j.bmcl.2003.10.070
10299717 64086 0 None -37 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813120 64086 0 None -37 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
10300724 64098 0 None -47 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813275 64098 0 None -47 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
9939791 161369 0 None -1071 8 Human 4.9 pKi = 4.9 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 684 8 1 5 7.2 CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F 10.1016/s0960-894x(99)00465-5
CHEMBL415310 161369 0 None -1071 8 Human 4.9 pKi = 4.9 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 684 8 1 5 7.2 CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F 10.1016/s0960-894x(99)00465-5
44402710 71615 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 431 7 1 4 5.2 O=C(O)COc1cccc2c1CCC(COC(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/j.bmcl.2005.04.047
CHEMBL197319 71615 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 431 7 1 4 5.2 O=C(O)COc1cccc2c1CCC(COC(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/j.bmcl.2005.04.047
44304334 199891 0 None -707 5 Human 5.9 pKi = 5.9 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL60555 199891 0 None -707 5 Human 5.9 pKi = 5.9 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
56682059 64490 0 None -53 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.08.065
CHEMBL1819619 64490 0 None -53 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.08.065
11269563 141078 0 None -12882 5 Human 4.9 pKi = 4.9 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 399 5 1 3 5.2 CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3 10.1021/jm0603668
CHEMBL385126 141078 0 None -12882 5 Human 4.9 pKi = 4.9 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 399 5 1 3 5.2 CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3 10.1021/jm0603668
138 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
1882 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
5280723 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
CHEMBL495 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
DB00770 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
138 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
1882 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
5280723 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
CHEMBL495 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
DB00770 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
138 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
1882 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
5280723 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
CHEMBL495 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
DB00770 3032 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
56678560 64102 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 518 7 1 7 4.7 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813279 64102 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 518 7 1 7 4.7 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
11488860 19095 0 None -36307 8 Human 4.8 pKi = 4.8 Binding
Binding affinity to prostanoid receptor IP receptorBinding affinity to prostanoid receptor IP receptor
ChEMBL 497 5 1 4 5.7 C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O 10.1016/j.bmcl.2010.10.018
CHEMBL1290413 19095 0 None -36307 8 Human 4.8 pKi = 4.8 Binding
Binding affinity to prostanoid receptor IP receptorBinding affinity to prostanoid receptor IP receptor
ChEMBL 497 5 1 4 5.7 C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O 10.1016/j.bmcl.2010.10.018
11198334 205997 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 331 4 2 6 1.9 COc1ccc(S(=O)(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9573 205997 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 331 4 2 6 1.9 COc1ccc(S(=O)(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11737656 206504 5 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 4 2 5 2.9 COc1ccc(Oc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9873 206504 5 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 4 2 5 2.9 COc1ccc(Oc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
56668353 64101 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813278 64101 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
56665068 64493 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1819622 64493 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
56665068 64493 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
CHEMBL1819622 64493 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
44400189 67149 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 449 7 1 3 7.1 O=C(O)Cc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL189378 67149 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 449 7 1 3 7.1 O=C(O)Cc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
57391066 67900 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 520 7 2 5 5.6 Cc1cc(C(=O)Nc2cc(C3(C(=O)O)CC3)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
CHEMBL1915864 67900 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 520 7 2 5 5.6 Cc1cc(C(=O)Nc2cc(C3(C(=O)O)CC3)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
56675399 64485 0 None -229 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cc(CC(=O)O)ccc1Cl 10.1016/j.bmc.2011.08.065
CHEMBL1819614 64485 0 None -229 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cc(CC(=O)O)ccc1Cl 10.1016/j.bmc.2011.08.065
11260449 67888 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1cc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
CHEMBL1915677 67888 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1cc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
11237257 67265 0 None -446 2 Human 5.7 pKi = 5.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 494 10 2 6 4.3 CC(c1ccccc1)(c1ccccc1)S(=O)(=O)CCc1c(CO)oc2c(OCC(=O)O)cccc12 10.1021/jm050194z
CHEMBL190288 67265 0 None -446 2 Human 5.7 pKi = 5.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 494 10 2 6 4.3 CC(c1ccccc1)(c1ccccc1)S(=O)(=O)CCc1c(CO)oc2c(OCC(=O)O)cccc12 10.1021/jm050194z
10116116 64080 0 None -25 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813115 64080 0 None -25 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
53358922 64099 0 None -38 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 6 1 6 5.3 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
CHEMBL1813276 64099 0 None -38 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 6 1 6 5.3 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
15947857 154975 8 None -1778 7 Human 5.7 pKi = 5.7 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 767 12 1 9 6.3 COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1 10.1016/j.bmcl.2008.01.103
CHEMBL404199 154975 8 None -1778 7 Human 5.7 pKi = 5.7 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 767 12 1 9 6.3 COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1 10.1016/j.bmcl.2008.01.103
10163305 64091 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(F)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813125 64091 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(F)c1 10.1016/j.bmc.2011.06.014
11374965 68851 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 5.7 CC(SCCc1c(CCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL192662 68851 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 5.7 CC(SCCc1c(CCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
56671851 64106 0 None -48 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.1 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813283 64106 0 None -48 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.1 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
9809136 106406 0 None -2089 8 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 614 7 1 4 7.1 CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
CHEMBL314533 106406 0 None -2089 8 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 614 7 1 4 7.1 CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
9895436 106533 0 None -1174 7 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 628 8 1 4 7.4 CC(C)(Cc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
CHEMBL315391 106533 0 None -1174 7 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 628 8 1 4 7.4 CC(C)(Cc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
53358921 64110 0 None -457 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813287 64110 0 None -457 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
56678561 64103 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c1C 10.1016/j.bmc.2011.06.014
CHEMBL1813280 64103 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c1C 10.1016/j.bmc.2011.06.014
21877027 206572 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 281 4 2 4 2.7 COc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9910 206572 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 281 4 2 4 2.7 COc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
10139183 67880 0 None -1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 456 6 1 6 4.2 CN1C[C@@H](COc2ccc(C(=O)n3ccc4c(CC(=O)O)cccc43)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1915669 67880 0 None -1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 456 6 1 6 4.2 CN1C[C@@H](COc2ccc(C(=O)n3ccc4c(CC(=O)O)cccc43)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
11220357 96896 5 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 301 5 2 3 3.6 CC/N=C(\N)Nc1ccc(Sc2ccc(OC)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL269403 96896 5 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 301 5 2 3 3.6 CC/N=C(\N)Nc1ccc(Sc2ccc(OC)cc2)cc1 10.1016/j.bmcl.2003.10.070
11186023 205628 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 311 4 2 4 4.3 CC(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9368 205628 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 311 4 2 4 4.3 CC(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
53494965 64482 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
CHEMBL1819611 64482 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
11236846 67885 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1cc(C)c(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
CHEMBL1915674 67885 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1cc(C)c(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
53494965 64482 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.007
CHEMBL1819611 64482 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.007
11350967 66851 0 None 11 2 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CCCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL187758 66851 0 None 11 2 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CCCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
56661652 64479 0 None -169 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 466 7 2 5 4.5 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1819609 64479 0 None -169 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 466 7 2 5 4.5 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
56664921 64107 0 None -39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.0 Cc1cc(OC[C@@H]2Cc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813284 64107 0 None -39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.0 Cc1cc(OC[C@@H]2Cc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
9938626 205106 0 None -1778 7 Human 4.6 pKi = 4.6 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 600 7 1 4 6.9 CC(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
CHEMBL90491 205106 0 None -1778 7 Human 4.6 pKi = 4.6 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 600 7 1 4 6.9 CC(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
56668527 64477 0 None -4 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 8 1 5 4.3 CCN(C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1)c1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
CHEMBL1819607 64477 0 None -4 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 8 1 5 4.3 CCN(C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1)c1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
11282605 67631 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 460 12 1 4 6.8 O=C(O)COc1cccc2c(CCCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL191175 67631 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 460 12 1 4 6.8 O=C(O)COc1cccc2c(CCCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
44219292 112090 30 None 25 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112090 30 None 25 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
138107701 186881 39 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 186881 39 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 186881 39 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
44304436 201629 0 None -8 5 Human 8.5 pKi = 8.5 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 400 14 3 5 3.8 CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
CHEMBL64854 201629 0 None -8 5 Human 8.5 pKi = 8.5 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 400 14 3 5 3.8 CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
56661510 64108 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 457 6 1 6 4.8 Cc1cc(OCC2Oc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813285 64108 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 457 6 1 6 4.8 Cc1cc(OCC2Oc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
11336395 206045 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 5 2 5 4.0 CC(C)Oc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9604 206045 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 5 2 5 4.0 CC(C)Oc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11255468 206105 3 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 314 4 2 6 3.1 O=[N+]([O-])c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9639 206105 3 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 314 4 2 6 3.1 O=[N+]([O-])c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
44266308 206287 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 295 4 2 5 2.3 COc1ccc(C(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9744 206287 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 295 4 2 5 2.3 COc1ccc(C(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11460304 206704 5 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 284 4 1 4 3.2 COc1ccc(Sc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9998 206704 5 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 284 4 1 4 3.2 COc1ccc(Sc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
22024188 96912 4 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 1 2 4 3.4 c1ccc2c(c1)sc1ccc(NC3=NCCN3)cc12 10.1016/j.bmcl.2003.10.070
CHEMBL269520 96912 4 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 1 2 4 3.4 c1ccc2c(c1)sc1ccc(NC3=NCCN3)cc12 10.1016/j.bmcl.2003.10.070
11254374 206013 1 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 275 3 2 4 3.5 c1cc(SC2CCCCC2)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
CHEMBL9583 206013 1 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 275 3 2 4 3.5 c1cc(SC2CCCCC2)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
10228100 64083 0 None -54 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813118 64083 0 None -54 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
56661509 64100 0 None -83 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 506 6 1 6 4.8 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
CHEMBL1813277 64100 0 None -83 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 506 6 1 6 4.8 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
57391065 67897 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 528 7 2 5 5.9 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(C)(C)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1915861 67897 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 528 7 2 5 5.9 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(C)(C)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
57403305 67898 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 7 2 5 5.8 Cc1cc(C(=O)Nc2cc(C(C)(C)C(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
CHEMBL1915862 67898 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 7 2 5 5.8 Cc1cc(C(=O)Nc2cc(C(C)(C)C(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
11260506 67200 0 None -19 2 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 6.0 CCC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL189694 67200 0 None -19 2 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 6.0 CCC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
11352417 67887 0 None -123 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c1C 10.1016/j.bmc.2011.08.065
CHEMBL1915676 67887 0 None -123 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c1C 10.1016/j.bmc.2011.08.065
56672019 64483 0 None -416 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1 10.1016/j.bmc.2011.08.007
CHEMBL1819612 64483 0 None -416 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1 10.1016/j.bmc.2011.08.007
56675398 64478 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.065
CHEMBL1819608 64478 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.065
56675398 64478 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
CHEMBL1819608 64478 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
10116114 125365 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL364841 125365 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
10116114 125365 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.065
CHEMBL364841 125365 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.065
10116114 125365 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.007
CHEMBL364841 125365 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.007
11278428 205961 4 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 5 2 5 3.6 CCOc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9552 205961 4 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 5 2 5 3.6 CCOc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11208785 205683 4 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1cccc(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
CHEMBL9398 205683 4 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1cccc(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
11461526 205971 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 325 3 2 4 4.5 CC(C)(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9558 205971 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 325 3 2 4 4.5 CC(C)(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11460765 97907 4 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2cccc(NC3=NCCN3)c2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL275233 97907 4 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2cccc(NC3=NCCN3)c2)cc1 10.1016/j.bmcl.2003.10.070
11324024 205760 3 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccccc1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9442 205760 3 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccccc1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
138107701 186881 39 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
5311181 186881 39 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
CHEMBL494 186881 39 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
127046072 139306 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptorBinding affinity to human IP receptor
ChEMBL 440 8 1 6 2.9 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccc3c(c2)OCO3)cc1 10.1016/j.bmcl.2016.04.043
CHEMBL3798917 139306 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptorBinding affinity to human IP receptor
ChEMBL 440 8 1 6 2.9 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccc3c(c2)OCO3)cc1 10.1016/j.bmcl.2016.04.043
CHEMBL3799044 139306 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptorBinding affinity to human IP receptor
ChEMBL 440 8 1 6 2.9 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccc3c(c2)OCO3)cc1 10.1016/j.bmcl.2016.04.043
11597294 165623 4 None -478 8 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 4 1 2 5.7 O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 10.1021/jm0603668
CHEMBL426387 165623 4 None -478 8 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 4 1 2 5.7 O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 10.1021/jm0603668
44234028 145339 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
CHEMBL3917503 145339 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
11201693 67048 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL188758 67048 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
10225921 14645 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 451 8 1 4 6.5 O=C(O)COc1cccc(C[C@@H]2CCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL1207206 14645 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 451 8 1 4 6.5 O=C(O)COc1cccc(C[C@@H]2CCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL363350 14645 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 451 8 1 4 6.5 O=C(O)COc1cccc(C[C@@H]2CCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
11316066 66973 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL188384 66973 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
10300616 64095 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813272 64095 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
56658143 64474 0 None -32 6 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 468 8 2 6 3.4 CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
CHEMBL1819604 64474 0 None -32 6 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 468 8 2 6 3.4 CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
11292620 68850 0 None 1 2 Human 5.3 pKi = 5.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 404 8 1 4 5.9 O=C(O)COc1cccc2c(CSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL192661 68850 0 None 1 2 Human 5.3 pKi = 5.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 404 8 1 4 5.9 O=C(O)COc1cccc2c(CSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
10185612 64082 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813117 64082 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
11392403 4482 5 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10241 4482 5 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11739220 204932 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.2 FC(F)(F)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL8935 204932 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.2 FC(F)(F)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11336790 206461 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 341 5 2 6 3.4 CCOC(=O)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9846 206461 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 341 5 2 6 3.4 CCOC(=O)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11403716 4177 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 296 4 2 5 2.8 COc1ccc(N(C)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10044 4177 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 296 4 2 5 2.8 COc1ccc(N(C)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11244046 4181 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 317 4 2 4 3.5 Clc1ccc(Sc2ccc(CNC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10045 4181 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 317 4 2 4 3.5 Clc1ccc(Sc2ccc(CNC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11460734 206708 5 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 298 5 1 4 3.4 COc1ccc(Sc2ccc(CC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9999 206708 5 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 298 5 1 4 3.4 COc1ccc(Sc2ccc(CC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
44234032 147392 0 None -7 6 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147392 0 None -7 6 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44304058 201487 0 None -223 5 Human 6.3 pKi = 6.3 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 374 13 3 6 2.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O 10.1016/s0960-894x(01)00364-x
CHEMBL64254 201487 0 None -223 5 Human 6.3 pKi = 6.3 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 374 13 3 6 2.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O 10.1016/s0960-894x(01)00364-x
21893828 64111 0 None -234 2 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2CC1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813288 64111 0 None -234 2 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2CC1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
56681899 64112 0 None -97 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 473 6 1 5 5.3 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813289 64112 0 None -97 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 473 6 1 5 5.3 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
57401554 67902 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 536 7 2 5 5.7 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(F)(F)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1915866 67902 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 536 7 2 5 5.7 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(F)(F)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
11294449 67884 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(C)c1C 10.1016/j.bmc.2011.08.065
CHEMBL1915673 67884 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(C)c1C 10.1016/j.bmc.2011.08.065
9874010 205461 0 None -3090 8 Human 4.3 pKi = 4.3 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 629 8 1 4 6.9 CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
CHEMBL92539 205461 0 None -3090 8 Human 4.3 pKi = 4.3 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 629 8 1 4 6.9 CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
11261579 67257 0 None -117 2 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 462 10 2 5 5.6 CC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL190236 67257 0 None -117 2 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 462 10 2 5 5.6 CC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
10028418 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.042
CHEMBL1205677 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.042
CHEMBL132589 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.042
10028418 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.047
CHEMBL1205677 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.047
CHEMBL132589 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.047
10028418 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2003.09.054
CHEMBL1205677 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2003.09.054
CHEMBL132589 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2003.09.054
10028418 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL1205677 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL132589 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
10028418 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL1205677 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL132589 14503 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
11293771 67327 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL190735 67327 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
56664920 64105 0 None -26 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 471 6 1 6 4.8 Cc1cc(OC[C@@H]2COc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813282 64105 0 None -26 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 471 6 1 6 4.8 Cc1cc(OC[C@@H]2COc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
11201307 67548 0 None -21 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 9 1 4 6.1 CC(SCCc1coc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL191056 67548 0 None -21 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 9 1 4 6.1 CC(SCCc1coc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
11750835 67110 0 None 5 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL189063 67110 0 None 5 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
11454655 67431 0 None -79 2 Human 5.2 pKi = 5.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 490 12 2 5 6.1 CC(SCCc1c(CCCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL190840 67431 0 None -79 2 Human 5.2 pKi = 5.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 490 12 2 5 6.1 CC(SCCc1c(CCCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
11519006 102013 0 None 151 6 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 481 8 1 5 6.1 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL2373410 102013 0 None 151 6 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 481 8 1 5 6.1 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL3040272 102013 0 None 151 6 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 481 8 1 5 6.1 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
138107701 186881 39 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
5311181 186881 39 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
CHEMBL494 186881 39 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
138107701 186881 39 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
5311181 186881 39 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
CHEMBL494 186881 39 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
10028418 14503 3 None 17 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205677 14503 3 None 17 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132589 14503 3 None 17 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
9955802 68842 0 None -112 3 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 435 6 1 3 7.1 O=C(O)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL192613 68842 0 None -112 3 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 435 6 1 3 7.1 O=C(O)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
11404217 97667 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NC(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL273530 97667 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NC(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11473193 97896 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.5 Clc1cccc(Cl)c1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL275124 97896 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.5 Clc1cccc(Cl)c1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
11381211 206008 4 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 305 4 2 2 4.2 CC/N=C(\N)Nc1ccc(Sc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9580 206008 4 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 305 4 2 2 4.2 CC/N=C(\N)Nc1ccc(Sc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2003.10.070
11370857 206125 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NC(C)(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9648 206125 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NC(C)(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11267409 206128 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 3 2 6 3.0 c1cc(Sc2ccc3c(c2)OCCO3)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
CHEMBL9649 206128 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 3 2 6 3.0 c1cc(Sc2ccc3c(c2)OCCO3)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
11174065 206498 3 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccccc2NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9868 206498 3 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccccc2NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
11224239 64473 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1819603 64473 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
11224239 64473 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
CHEMBL1819603 64473 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
3356 2248 68 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
4326 2248 68 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
9867642 2248 68 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
CHEMBL426559 2248 68 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
DB11629 2248 68 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
11166017 66803 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL187544 66803 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
44234032 147392 0 None 7 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147392 0 None 7 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
138107701 186881 39 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
5311181 186881 39 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
CHEMBL494 186881 39 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
11743212 16982 0 None -234 7 Human 6.2 pKi = 6.2 Binding
Ability to inhibit the binding of human IP receptor to Prostaglandin I2 receptorAbility to inhibit the binding of human IP receptor to Prostaglandin I2 receptor
ChEMBL 426 7 1 3 6.8 O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 10.1016/s0960-894x(03)00794-7
CHEMBL125588 16982 0 None -234 7 Human 6.2 pKi = 6.2 Binding
Ability to inhibit the binding of human IP receptor to Prostaglandin I2 receptorAbility to inhibit the binding of human IP receptor to Prostaglandin I2 receptor
ChEMBL 426 7 1 3 6.8 O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 10.1016/s0960-894x(03)00794-7
10227894 64089 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813123 64089 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
10181606 204628 0 None -288 7 Human 5.1 pKi = 5.1 Binding
Inhibitory constant against Prostanoid IP receptorInhibitory constant against Prostanoid IP receptor
ChEMBL 437 5 1 4 5.2 O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)00518-8
CHEMBL87371 204628 0 None -288 7 Human 5.1 pKi = 5.1 Binding
Inhibitory constant against Prostanoid IP receptorInhibitory constant against Prostanoid IP receptor
ChEMBL 437 5 1 4 5.2 O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)00518-8
44304388 201462 0 None -1513 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL64187 201462 0 None -1513 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O 10.1016/s0960-894x(01)00365-1
11282319 67322 0 None -8 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 448 10 2 5 5.5 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)c(CO)oc12 10.1021/jm050194z
CHEMBL190708 67322 0 None -8 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 448 10 2 5 5.5 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)c(CO)oc12 10.1021/jm050194z
44219292 112090 30 None -25 7 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112090 30 None -25 7 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
10139047 12724 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1188479 12724 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL439357 12724 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
11318288 67609 0 None -5 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 516 10 2 5 6.2 O=C(O)COc1cccc2c(CCSC(c3ccccc3)(c3ccccc3)C(F)(F)F)c(CO)oc12 10.1021/jm050194z
CHEMBL191118 67609 0 None -5 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 516 10 2 5 6.2 O=C(O)COc1cccc2c(CCSC(c3ccccc3)(c3ccccc3)C(F)(F)F)c(CO)oc12 10.1021/jm050194z
11186079 4146 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10024 4146 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11175906 205636 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 362 5 3 6 2.6 CS(=O)(=O)Nc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9371 205636 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 362 5 3 6 2.6 CS(=O)(=O)Nc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11243628 206520 4 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 303 3 2 4 3.9 Clc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9883 206520 4 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 303 3 2 4 3.9 Clc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11391560 167182 5 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 269 3 2 4 3.2 c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL430286 167182 5 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 269 3 2 4 3.2 c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11244380 206077 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 329 5 2 6 3.2 COc1ccc(OC)c(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
CHEMBL9626 206077 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 329 5 2 6 3.2 COc1ccc(OC)c(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
5855 1615 4 None 257 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2005.04.047
9911469 1615 4 None 257 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2005.04.047
CHEMBL196779 1615 4 None 257 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2005.04.047
11407826 123129 0 None 38 2 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.0 O=C(O)COc1cccc2c(CCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL361939 123129 0 None 38 2 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.0 O=C(O)COc1cccc2c(CCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
44326793 14485 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 398 8 3 4 3.3 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3OC2C[C@H]1O 10.1016/s0960-894x(00)00571-0
CHEMBL1205415 14485 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 398 8 3 4 3.3 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3OC2C[C@H]1O 10.1016/s0960-894x(00)00571-0
CHEMBL94694 14485 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 398 8 3 4 3.3 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3OC2C[C@H]1O 10.1016/s0960-894x(00)00571-0
13231966 100484 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL294108 100484 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
1892 736 15 None -104 9 Human 6.1 pKi = 6.1 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
25886893 736 15 None -104 9 Human 6.1 pKi = 6.1 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
CHEMBL1628262 736 15 None -104 9 Human 6.1 pKi = 6.1 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
44304181 201582 0 None -12 2 Human 6.1 pKi = 6.1 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
CHEMBL64663 201582 0 None -12 2 Human 6.1 pKi = 6.1 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
13231966 100484 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
CHEMBL294108 100484 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
56675229 64090 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(Cl)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813124 64090 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(Cl)c1 10.1016/j.bmc.2011.06.014
10278907 64087 0 None -20 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
CHEMBL1813121 64087 0 None -20 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
44304474 201242 0 None -245 5 Human 6.0 pKi = 6.0 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL62868 201242 0 None -245 5 Human 6.0 pKi = 6.0 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O 10.1016/s0960-894x(01)00365-1
56681898 64104 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813281 64104 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
56678559 64097 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813274 64097 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
9934864 205812 7 None - 1 Human 7.0 pKi = 7.0 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/s0960-894x(00)00571-0
CHEMBL94751 205812 7 None - 1 Human 7.0 pKi = 7.0 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/s0960-894x(00)00571-0
10117702 64096 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c1C 10.1016/j.bmc.2011.06.014
CHEMBL1813273 64096 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c1C 10.1016/j.bmc.2011.06.014
127029417 138905 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity to human IP receptor by competitive binding assayBinding affinity to human IP receptor by competitive binding assay
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793911 138905 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity to human IP receptor by competitive binding assayBinding affinity to human IP receptor by competitive binding assay
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
10501053 1557 0 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CC[C@@H]([C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1c1cccc(c1O2)CCCC(=O)O)O)C 2665758
8314 1557 0 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CC[C@@H]([C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1c1cccc(c1O2)CCCC(=O)O)O)C 2665758
CHEMBL3137314 1557 0 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CC[C@@H]([C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1c1cccc(c1O2)CCCC(=O)O)O)C 2665758
1968 3697 0 None - 1 Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 22480736
5311243 3697 0 None - 1 Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 22480736
CHEMBL2104890 3697 0 None - 1 Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 22480736
1917 914 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 914 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 914 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 914 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
119461 317 66 3H-ILOPROST -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
1896 317 66 3H-ILOPROST -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
CHEMBL1317823 317 66 3H-ILOPROST -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
119304 741 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
1878 741 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
40481312 741 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
CHEMBL575504 741 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
1940 1633 38 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
3417 1633 38 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
5311100 1633 38 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
CHEMBL1201379 1633 38 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
DB11519 1633 38 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
1551 2254 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1961 2254 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
5311221 2254 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
CHEMBL1051 2254 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
DB00654 2254 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1913 2429 0 3H-ILOPROST -70794 15 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O None
5311223 2429 0 3H-ILOPROST -70794 15 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O None
1817 2506 60 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
1936 2506 60 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
5282381 2506 60 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
CHEMBL606 2506 60 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
DB00929 2506 60 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
1881 3030 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1891 3030 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
448457 3030 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL1235252 3030 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB02056 3030 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1883 3033 71 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1883 3033 71 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1883 3033 71 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 3033 71 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 3033 71 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 3033 71 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 3033 71 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 3033 71 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 3033 71 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 3033 71 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 3033 71 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 3033 71 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 3033 71 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 3033 71 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 3033 71 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 3033 71 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 3033 71 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 3033 71 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1884 3034 46 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1884 3034 46 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1884 3034 46 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 3034 46 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 3034 46 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 3034 46 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 3034 46 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 3034 46 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 3034 46 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 3034 46 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 3034 46 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 3034 46 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 3034 46 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 3034 46 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 3034 46 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1980 3605 0 3H-ILOPROST -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
1985 3605 0 3H-ILOPROST -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
6437074 3605 0 3H-ILOPROST -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
1888 3837 26 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
1974 3837 26 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
5311493 3837 26 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
CHEMBL521784 3837 26 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
5311035 97354 27 3H-ILOPROST -91 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 None
CHEMBL271896 97354 27 3H-ILOPROST -91 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 None
1973 201790 12 3H-ILOPROST -3 35 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 201790 12 3H-ILOPROST -3 35 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 201790 12 3H-ILOPROST -3 35 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
134689669 214279 0 3H-ILOPROST -5495 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 465 12 3 7 1.7 CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
91798918 214292 0 3H-ILOPROST -1479 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 400 10 2 6 2.6 COC(=O)CCC=C=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
67861203 214294 0 3H-ILOPROST -21379 8 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 424 11 4 5 3.2 C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)O)O None
132748 214665 0 3H-ILOPROST -7 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 3 2 4 4.6 C1C2=CC=CC=C2OC3=C(N1C(=O)NNC(=O)CCC4=CC=NC=C4)C=C(C=C3)Cl.Cl None
None 214667 0 3H-ILOPROST -10 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 477 11 1 5 5.1 C1CC(=O)CC1CCC(=CCC(C(=O)O)N2CCOCC2)OCC3=CC=C(C=C3)C4=CC=CC=C4 None
None 214709 0 Functional -19 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCCC(C=CC1C(C(CC1=O)O)CCCCCCC(=O)O)O None
None 214709 0 3H-PGI2 -19 3 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCCC(C=CC1C(C(CC1=O)O)CCCCCCC(=O)O)O None
None 214713 0 3H-PGI2 1 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 356 13 4 4 3.3 CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O None
None 214713 0 3H-PGI2 -1 2 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 356 13 4 4 3.3 CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O None
89077401 214273 0 3H-ILOPROST -1 12 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 360 8 3 3 3.5 CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
89077401 214273 0 3H-ILOPROST -1 12 Mouse 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 360 8 3 3 3.5 CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
133126726 214274 0 3H-ILOPROST -4 14 Mouse 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 214274 0 3H-ILOPROST -4 14 Mouse 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
138 3032 84 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
138 3032 84 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3032 84 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3032 84 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3032 84 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3032 84 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3032 84 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3032 84 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3032 84 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3032 84 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
None 214275 0 3H-ILOPROST 2 3 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 11 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=C2)CCCCC(=O)O)O)O None
None 214276 0 3H-ILOPROST 6 2 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 398 8 3 4 3.3 CC#CCC(C)C(C=CC1C(CC2C1C3=C(O2)C(=CC=C3)CCCC(=O)O)O)O None
133126726 214274 0 3H-PGI2 -3 14 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
133126726 214274 0 3H-PGI2 -4 14 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 214274 0 3H-PGI2 -3 14 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 214274 0 3H-PGI2 -4 14 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
1917 914 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 914 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 914 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 914 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
None 214666 0 3H-ILOPROST -7079 6 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 384 9 3 3 4.3 C1CCC(CC1)C(C=CC2C(CC(C2CC=CCCCC(=O)O)Cl)O)O None
133126726 214274 0 3H-ILOPROST -3 14 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 214274 0 3H-ILOPROST -3 14 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
138 3032 84 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3032 84 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3032 84 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3032 84 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3032 84 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
None 214277 0 3H-ILOPROST 15 2 Mouse 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 442 9 1 5 5.1 CC1=C(C2=C(CC1)C(=CC=C2)OCC(=O)O)CCON=C(C3=CC=CC=C3)C4=CN=CC=C4 None
3356 2248 68 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
4326 2248 68 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
9867642 2248 68 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
CHEMBL426559 2248 68 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
DB11629 2248 68 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
5077 3522 72 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
7552 3522 72 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
9913767 3522 72 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
CHEMBL238804 3522 72 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
DB11362 3522 72 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
138 3032 84 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3032 84 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3032 84 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3032 84 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3032 84 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5077 3522 72 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
7552 3522 72 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
9913767 3522 72 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
CHEMBL238804 3522 72 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
DB11362 3522 72 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
69658829 215961 0 None -1 4 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 398 8 3 4 3.3 CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC3=C(C=CC=C3CCCC(O)=O)[C@H]12 None
1917 914 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 914 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 914 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 914 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
133126726 214274 0 None -3 14 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 214274 0 None -3 14 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
69658829 215961 0 None -1 4 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 398 8 3 4 3.3 CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC3=C(C=CC=C3CCCC(O)=O)[C@H]12 None
None 214712 0 3H-PGI2 1 2 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 354 11 3 4 3.3 CCCCCC(C=CC1C2CC(OC2CC1O)CCCCC(=O)O)O None
None 214712 0 3H-PGI2 -1 2 Mouse 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 354 11 3 4 3.3 CCCCCC(C=CC1C2CC(OC2CC1O)CCCCC(=O)O)O None
1917 914 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 914 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 914 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 914 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
138107701 186881 39 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 186881 39 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 186881 39 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5077 3522 72 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
7552 3522 72 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9913767 3522 72 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL238804 3522 72 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
DB11362 3522 72 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
5077 3522 72 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
7552 3522 72 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9913767 3522 72 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL238804 3522 72 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
DB11362 3522 72 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
138 3032 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
138 3032 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
1882 3032 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
1882 3032 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
5280723 3032 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
5280723 3032 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
CHEMBL495 3032 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
CHEMBL495 3032 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
DB00770 3032 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
DB00770 3032 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
5852 2579 47 None -10 4 Rat 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9931891 2579 47 None -10 4 Rat 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL239226 2579 47 None -10 4 Rat 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
10204312 3296 0 None - 1 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
4042 3296 0 None - 1 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
10141039 1657 0 None - 1 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 8 1 4 6.9 OC(=O)COc1cccc(c1)CC1CCCC=C1c1nc(c(o1)c1ccccc1)c1ccccc1 16837197
5854 1657 0 None - 1 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 8 1 4 6.9 OC(=O)COc1cccc(c1)CC1CCCC=C1c1nc(c(o1)c1ccccc1)c1ccccc1 16837197
1967 594 0 None -2 5 Human 7.4 pKi = 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
5282428 594 0 None -2 5 Human 7.4 pKi = 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
2720 3793 55 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
5820 3793 55 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
6918140 3793 55 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
CHEMBL1237119 3793 55 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
DB00374 3793 55 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
5852 2579 47 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
5852 2579 47 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 23850788
9931891 2579 47 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9931891 2579 47 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 23850788
CHEMBL239226 2579 47 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL239226 2579 47 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 23850788
1967 594 0 None -1 5 Rat 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
5282428 594 0 None -1 5 Rat 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
1895 1976 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
1895 1976 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
6435378 1976 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
6435378 1976 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
CHEMBL236025 1976 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
CHEMBL236025 1976 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
DB01088 1976 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
DB01088 1976 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
1967 594 0 None 1 5 Mouse 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 9313928
5282428 594 0 None 1 5 Mouse 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 9313928
1917 914 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
5311044 914 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
631 914 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
CHEMBL160629 914 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
1034 3036 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
1915 3036 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
5282411 3036 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
CHEMBL1139 3036 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
DB01240 3036 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
5855 1615 4 None 257 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 15914004
9911469 1615 4 None 257 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 15914004
CHEMBL196779 1615 4 None 257 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 15914004
1969 798 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
9839644 798 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
CHEMBL9540 798 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
1888 3837 26 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
1974 3837 26 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
5311493 3837 26 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
CHEMBL521784 3837 26 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
1892 736 15 None -104 9 Human 4.3 pKi None 4.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10634944
25886893 736 15 None -104 9 Human 4.3 pKi None 4.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10634944
CHEMBL1628262 736 15 None -104 9 Human 4.3 pKi None 4.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10634944
1893 783 0 None -19 13 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
5311242 783 0 None -19 13 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
CHEMBL148319 783 0 None -19 13 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
1893 783 0 None -7 13 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
5311242 783 0 None -7 13 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
CHEMBL148319 783 0 None -7 13 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
1964 2884 0 None - 1 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 9 1 5 4.7 OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1 9313928
6536812 2884 0 None - 1 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 9 1 5 4.7 OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1 9313928
CHEMBL188539 2884 0 None - 1 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 9 1 5 4.7 OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1 9313928
138 3032 84 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
1882 3032 84 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
5280723 3032 84 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
CHEMBL495 3032 84 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
DB00770 3032 84 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
1934 2059 0 None 1 3 Mouse 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 11 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O 9313928
5311244 2059 0 None 1 3 Mouse 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 11 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O 9313928
CHEMBL4522827 2059 0 None 1 3 Mouse 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 11 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O 9313928
1917 914 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
5311044 914 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
631 914 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
CHEMBL160629 914 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
1895 1976 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928
6435378 1976 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928
CHEMBL236025 1976 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928
DB01088 1976 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928