Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
44378315 57163 7 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 332 14 0 3 5.5 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC 10.1016/j.bmc.2018.05.036
CHEMBL165682 57163 7 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 332 14 0 3 5.5 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC 10.1016/j.bmc.2018.05.036
145962053 161084 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 330 13 0 3 5.3 CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC 10.1016/j.bmc.2018.05.036
CHEMBL4130040 161084 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 330 13 0 3 5.3 CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC 10.1016/j.bmc.2018.05.036
3391 155 17 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
3416 155 17 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
5283159 155 17 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
CHEMBL18028 155 17 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
102164179 160888 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 316 13 1 2 5.2 CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
CHEMBL4127146 160888 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 316 13 1 2 5.2 CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
6167 152 7 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1016/j.bmcl.2011.01.032
6438757 152 7 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1016/j.bmcl.2011.01.032
CHEMBL1682258 152 7 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1016/j.bmcl.2011.01.032
3391 155 17 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1039/C1MD00231G
3416 155 17 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1039/C1MD00231G
5283159 155 17 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1039/C1MD00231G
CHEMBL18028 155 17 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1039/C1MD00231G
3391 155 17 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.01.032
3416 155 17 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.01.032
5283159 155 17 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.01.032
CHEMBL18028 155 17 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.01.032
122588275 166205 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 C[C@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4283608 166205 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 C[C@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
122588230 166440 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 CC(CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4287941 166440 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 CC(CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
145980814 166085 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4281149 166085 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
122588209 166261 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 439 11 1 3 6.5 CC(CC(=O)O)CC(=O)c1c(CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4284672 166261 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 439 11 1 3 6.5 CC(CC(=O)O)CC(=O)c1c(CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
49800286 104826 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 9 1 3 5.3 CCCCCCc1cc2ccccc2n1C(=O)CC(C)(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115781 104826 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 9 1 3 5.3 CCCCCCc1cc2ccccc2n1C(=O)CC(C)(C)CC(=O)O 10.1021/jm401292m
49802318 156161 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.9 CCCCCCc1c(C(=O)c2cccc(C(=O)O)c2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4070005 156161 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.9 CCCCCCc1c(C(=O)c2cccc(C(=O)O)c2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49804576 86911 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL2332567 86911 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
71717596 86909 1 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 265 4 1 3 3.2 O=C(O)CCCC(=O)n1ccc2cc(Cl)ccc21 10.1021/jm400480j
CHEMBL2332561 86909 1 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 265 4 1 3 3.2 O=C(O)CCCC(=O)n1ccc2cc(Cl)ccc21 10.1021/jm400480j
49800562 86908 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cccc2ccn(C(=O)CCCC(=O)O)c12 10.1021/jm400480j
CHEMBL2332560 86908 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cccc2ccn(C(=O)CCCC(=O)O)c12 10.1021/jm400480j
145984927 165874 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 439 11 1 3 6.8 CC(CC(=O)O)CC(=O)n1c(CCCCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
CHEMBL4277299 165874 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 439 11 1 3 6.8 CC(CC(=O)O)CC(=O)n1c(CCCCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
145984923 165869 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4277207 165869 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
137638047 156236 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)CC(C)(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4070795 156236 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)CC(C)(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
76336045 104828 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 9 1 3 5.2 CCCCCCc1c(C)c2ccccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115783 104828 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 9 1 3 5.2 CCCCCCc1c(C)c2ccccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
137644937 157942 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.9 CCCCCCc1c(C(=O)c2ccc(C(=O)O)cc2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4090987 157942 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.9 CCCCCCc1c(C(=O)c2ccc(C(=O)O)cc2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49800561 104839 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 287 7 1 3 3.9 CCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115794 104839 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 287 7 1 3 3.9 CCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
66644017 104830 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2cc(Cl)ccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115785 104830 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2cc(Cl)ccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
49804576 86911 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm400480j
CHEMBL2332567 86911 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm400480j
66644128 104822 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL3115775 104822 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49800843 104825 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 341 9 1 3 5.0 CCCCCCc1cc2ccccc2n1C(=O)CC1(CC(=O)O)CC1 10.1021/jm401292m
CHEMBL3115780 104825 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 341 9 1 3 5.0 CCCCCCc1cc2ccccc2n1C(=O)CC1(CC(=O)O)CC1 10.1021/jm401292m
49802029 104821 5 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/acs.jmedchem.8b00154
CHEMBL3115774 104821 5 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/acs.jmedchem.8b00154
66644128 104822 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/acs.jmedchem.8b00154
CHEMBL3115775 104822 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/acs.jmedchem.8b00154
49800564 86906 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1ccc2c(ccn2C(=O)CCCC(=O)O)c1 10.1021/jm400480j
CHEMBL2332558 86906 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1ccc2c(ccn2C(=O)CCCC(=O)O)c1 10.1021/jm400480j
49802029 104821 5 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
CHEMBL3115774 104821 5 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
145986668 166635 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 411 9 1 3 6.0 CC(CC(=O)O)CC(=O)n1c(CCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
CHEMBL4291346 166635 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 411 9 1 3 6.0 CC(CC(=O)O)CC(=O)n1c(CCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
49800839 86907 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1ccc2ccn(C(=O)CCCC(=O)O)c2c1 10.1021/jm400480j
CHEMBL2332559 86907 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1ccc2ccn(C(=O)CCCC(=O)O)c2c1 10.1021/jm400480j
118707104 112513 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 361 8 1 3 5.6 CCCC/C=C/c1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
CHEMBL3311229 112513 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 361 8 1 3 5.6 CCCC/C=C/c1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
145979967 166140 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 425 10 1 3 6.4 CC(CC(=O)O)CC(=O)n1c(CCCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
CHEMBL4282356 166140 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 425 10 1 3 6.4 CC(CC(=O)O)CC(=O)n1c(CCCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
49802316 114397 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)C[C@H](C)CC(=O)O 10.1021/ml500161v
CHEMBL3341973 114397 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)C[C@H](C)CC(=O)O 10.1021/ml500161v
49802026 114395 2 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/ml500161v
CHEMBL3341971 114395 2 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/ml500161v
1051 1427 56 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
4289 1427 56 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
445580 1427 56 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
57417355 1427 56 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
CHEMBL367149 1427 56 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
DB03756 1427 56 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
3174 1540 61 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
3362 1540 61 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
446284 1540 61 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
CHEMBL460026 1540 61 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
DB00159 1540 61 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
5312529 173318 26 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 306 15 1 1 6.4 CC/C=C\C/C=C\C/C=C\CCCCCCCCCC(=O)O 10.1021/jm401292m
CHEMBL453991 173318 26 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 306 15 1 1 6.4 CC/C=C\C/C=C\C/C=C\CCCCCCCCCC(=O)O 10.1021/jm401292m
5280581 177781 38 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 306 15 1 1 6.4 CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O 10.1021/jm401292m
CHEMBL465183 177781 38 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 306 15 1 1 6.4 CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O 10.1021/jm401292m
49804582 86905 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cn(C(=O)CCCC(=O)O)c2ccccc12 10.1021/jm400480j
CHEMBL2332557 86905 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cn(C(=O)CCCC(=O)O)c2ccccc12 10.1021/jm400480j
145979016 166063 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.6 CC(CC(=O)O)CC(=O)n1c(CCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
CHEMBL4280693 166063 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.6 CC(CC(=O)O)CC(=O)n1c(CCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
49800284 104840 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 301 8 1 3 4.3 CCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115795 104840 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 301 8 1 3 4.3 CCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
49802029 104821 5 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 104821 5 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
122588268 166417 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 411 9 1 3 5.7 CC(CC(=O)O)CC(=O)c1c(CCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4287509 166417 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 411 9 1 3 5.7 CC(CC(=O)O)CC(=O)c1c(CCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
137647550 157431 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 447 15 1 3 7.6 CCCCCCCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4084871 157431 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 447 15 1 3 7.6 CCCCCCCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
122600362 166644 3 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 C[C@@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4291464 166644 3 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 C[C@@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
10544716 104823 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@H](O)/C=C/C=C/C=C/C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115777 104823 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@H](O)/C=C/C=C/C=C/C(=O)CCCC(=O)O 10.1021/jm401292m
76317856 104838 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 421 10 1 3 5.7 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Br)ccc2n1C 10.1021/jm401292m
CHEMBL3115793 104838 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 421 10 1 3 5.7 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Br)ccc2n1C 10.1021/jm401292m
145993055 166285 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@H](CC(=O)O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4285167 166285 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@H](CC(=O)O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
49802026 114395 2 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL3341971 114395 2 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
66644128 104822 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 104822 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
49802029 104821 5 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 104821 5 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
66644128 104822 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 104822 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
3391 155 17 None - 1 Human 8.5 pIC50 = 8.5 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.02.021
3416 155 17 None - 1 Human 8.5 pIC50 = 8.5 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.02.021
5283159 155 17 None - 1 Human 8.5 pIC50 = 8.5 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.02.021
CHEMBL18028 155 17 None - 1 Human 8.5 pIC50 = 8.5 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.02.021
76328737 104831 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 407 9 1 3 5.7 CCCCCCc1cc2ccc(Br)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115786 104831 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 407 9 1 3 5.7 CCCCCCc1cc2ccc(Br)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
49804581 104836 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 10 1 3 5.0 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2ccccc2n1C 10.1021/jm401292m
CHEMBL3115791 104836 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 10 1 3 5.0 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2ccccc2n1C 10.1021/jm401292m
76332419 104832 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 359 10 1 4 4.9 CCCCCCc1cc2ccc(OC)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115787 104832 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 359 10 1 4 4.9 CCCCCCc1cc2ccc(OC)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
145982307 165958 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 431 10 1 3 6.2 CC(CC(=O)O)CC(=O)c1c(CCCCCC(F)(F)F)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4278772 165958 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 431 10 1 3 6.2 CC(CC(=O)O)CC(=O)c1c(CCCCCC(F)(F)F)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
122600340 166003 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 425 10 1 3 6.1 CC(CC(=O)O)CC(=O)c1c(CCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4279605 166003 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 425 10 1 3 6.1 CC(CC(=O)O)CC(=O)c1c(CCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
71720638 86910 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 265 4 1 3 3.2 O=C(O)CCCC(=O)n1ccc2ccc(Cl)cc21 10.1021/jm400480j
CHEMBL2332562 86910 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 265 4 1 3 3.2 O=C(O)CCCC(=O)n1ccc2ccc(Cl)cc21 10.1021/jm400480j
66644266 104841 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 313 8 1 3 4.7 CCCC/C=C/c1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115796 104841 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 313 8 1 3 4.7 CCCC/C=C/c1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
137660364 158507 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)CCC(C)(C)C(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4096962 158507 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)CCC(C)(C)C(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
118707105 112514 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 361 8 1 3 5.6 CCCC/C=C\c1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
CHEMBL3311230 112514 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 361 8 1 3 5.6 CCCC/C=C\c1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
10568747 151 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1021/jm401292m
6171 151 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1021/jm401292m
CHEMBL3115778 151 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1021/jm401292m
3404 12 25 None -1778 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay
ChEMBL 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 10.1021/acs.jmedchem.8b00154
5283155 12 25 None -1778 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay
ChEMBL 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 10.1021/acs.jmedchem.8b00154
5508 12 25 None -1778 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay
ChEMBL 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 10.1021/acs.jmedchem.8b00154
CHEMBL1526258 12 25 None -1778 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay
ChEMBL 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 10.1021/acs.jmedchem.8b00154
68036050 104845 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 383 13 1 3 6.7 CCCCCCCCC/C=C\c1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115800 104845 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 383 13 1 3 6.7 CCCCCCCCC/C=C\c1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
137655720 158437 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 365 10 1 4 4.2 CCCCCCc1c(C(=O)COCC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4096265 158437 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 365 10 1 4 4.2 CCCCCCc1c(C(=O)COCC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49801419 104835 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 10 1 3 5.4 CCCCCCc1c(C(=O)CCCC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115790 104835 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 10 1 3 5.4 CCCCCCc1c(C(=O)CCCC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
49800560 104843 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 11 1 3 5.4 CCCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115798 104843 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 11 1 3 5.4 CCCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
137645745 157105 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 389 10 1 3 5.8 CCCCCCc1c(C(=O)CC2(CC(=O)O)CC2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4081391 157105 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 389 10 1 3 5.8 CCCCCCc1c(C(=O)CC2(CC(=O)O)CC2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
66644128 104822 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 104822 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
49778909 114396 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49778909 114396 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/acs.jmedchem.8b00154
CHEMBL3341972 114396 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL3341972 114396 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/acs.jmedchem.8b00154
49778909 114396 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/ml500161v
CHEMBL3341972 114396 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/ml500161v
49804580 104834 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 10 1 3 4.7 CCCCCCc1c(C(=O)CCCC(=O)O)c2ccccc2n1C 10.1021/jm401292m
CHEMBL3115789 104834 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 10 1 3 4.7 CCCCCCc1c(C(=O)CCCC(=O)O)c2ccccc2n1C 10.1021/jm401292m
76336046 104829 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 407 9 1 3 5.7 CCCCCCc1cc2cc(Br)ccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115784 104829 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 407 9 1 3 5.7 CCCCCCc1cc2cc(Br)ccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
49802029 104821 5 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 104821 5 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
49802029 104821 5 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/ml500161v
CHEMBL3115774 104821 5 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/ml500161v
53248990 60356 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 372 14 1 2 5.9 O=C(O)CCCC(=O)/C=C/C=C\C/C=C\C/C=C\CCCCC(F)(F)F 10.1016/j.bmcl.2011.02.021
CHEMBL1760545 60356 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 372 14 1 2 5.9 O=C(O)CCCC(=O)/C=C/C=C\C/C=C\C/C=C\CCCCC(F)(F)F 10.1016/j.bmcl.2011.02.021
49800558 104844 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 385 14 1 3 6.6 CCCCCCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115799 104844 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 385 14 1 3 6.6 CCCCCCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
137655326 158015 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 403 10 1 3 6.2 CCCCCCc1c(C(=O)CC2(CC(=O)O)CCC2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4091674 158015 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 403 10 1 3 6.2 CCCCCCc1c(C(=O)CC2(CC(=O)O)CCC2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49800841 104842 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 10 1 3 5.0 CCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115797 104842 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 10 1 3 5.0 CCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
145989845 166684 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@@H](CC(=O)O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4292357 166684 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@@H](CC(=O)O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
49802589 104837 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2ccc(Cl)cc2n1C 10.1021/jm401292m
CHEMBL3115792 104837 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2ccc(Cl)cc2n1C 10.1021/jm401292m
137638887 156144 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)C(C)(C)CCC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4069768 156144 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)C(C)(C)CCC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49804577 104827 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 9 1 3 4.9 CCCCCCc1cc2ccccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115782 104827 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 9 1 3 4.9 CCCCCCc1cc2ccccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
66644000 104833 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 315 10 2 2 4.7 CCCCCCc1[nH]c2ccccc2c1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115788 104833 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 315 10 2 2 4.7 CCCCCCc1[nH]c2ccccc2c1C(=O)CCCC(=O)O 10.1021/jm401292m
6169 153 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 15 2 3 4.4 OCCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 8598482
73755178 153 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 15 2 3 4.4 OCCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 8598482
3390 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 16039985
3390 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 7803484
3390 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 8387490
5280733 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 16039985
5280733 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 7803484
5280733 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 8387490
CHEMBL164813 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 16039985
CHEMBL164813 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 7803484
CHEMBL164813 158 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 8387490
2483 159 0 None - 1 Human 7.0 pEC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 15 2 3 5.7 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)OO 16039985
5280778 159 0 None - 1 Human 7.0 pEC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 15 2 3 5.7 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)OO 16039985
CHEMBL1743204 159 0 None - 1 Human 7.0 pEC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 15 2 3 5.7 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)OO 16039985
6167 152 7 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7797484
6167 152 7 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7803484
6167 152 7 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8387490
6167 152 7 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8598482
6438757 152 7 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7797484
6438757 152 7 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7803484
6438757 152 7 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8387490
6438757 152 7 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8598482
CHEMBL1682258 152 7 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7797484
CHEMBL1682258 152 7 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7803484
CHEMBL1682258 152 7 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8387490
CHEMBL1682258 152 7 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8598482
3392 154 0 None - 1 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 15 1 2 5.6 CCCCCCCC/C=C\C/C=C\C=C/C(=O)CCCC(=O)O 18292294
56947094 154 0 None - 1 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 15 1 2 5.6 CCCCCCCC/C=C\C/C=C\C=C/C(=O)CCCC(=O)O 18292294
6164 156 0 None - 1 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 294 14 1 2 5.1 CCCCCCCCC/C=C\C=C\C(=O)CCCC(=O)O 18287092
71751402 156 0 None - 1 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 294 14 1 2 5.1 CCCCCCCCC/C=C\C=C\C(=O)CCCC(=O)O 18287092
3391 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 1326548
3391 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 18292294
3391 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 19450703
3391 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 7797484
3391 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
3416 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 1326548
3416 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 18292294
3416 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 19450703
3416 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 7797484
3416 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
5283159 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 1326548
5283159 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 18292294
5283159 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 19450703
5283159 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 7797484
5283159 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
CHEMBL18028 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 1326548
CHEMBL18028 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 18292294
CHEMBL18028 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 19450703
CHEMBL18028 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 7797484
CHEMBL18028 155 17 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
11073 2054 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Inhibition of 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils.Inhibition of 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils.
Guide to Pharmacology 487 12 1 3 7.5 C[C@@H](CC(=O)c1c(CCCCCCc2cccc(c2)Cl)n(c2c1cc(Cl)cc2)C)CC(=O)O 31655025
122588231 2054 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Inhibition of 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils.Inhibition of 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils.
Guide to Pharmacology 487 12 1 3 7.5 C[C@@H](CC(=O)c1c(CCCCCCc2cccc(c2)Cl)n(c2c1cc(Cl)cc2)C)CC(=O)O 31655025
10568747 151 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 9920859
6171 151 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 9920859
CHEMBL3115778 151 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 9920859
6174 127 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 349 9 1 3 5.3 CCCCCCc1cc2c(n1C(=O)CCCC(=O)O)cc(cc2)Cl 23581530
71655222 127 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 349 9 1 3 5.3 CCCCCCc1cc2c(n1C(=O)CCCC(=O)O)cc(cc2)Cl 23581530
5066134 1861 0 None - 1 Human 6.0 pIC50 ~ 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 447 5 1 6 6.4 CSc1nc2c(s1)c1sc(nc1cc2)NC(=O)C(c1ccccc1)c1ccccc1 22634634
6173 1861 0 None - 1 Human 6.0 pIC50 ~ 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 447 5 1 6 6.4 CSc1nc2c(s1)c1sc(nc1cc2)NC(=O)C(c1ccccc1)c1ccccc1 22634634
CHEMBL4303495 1861 0 None - 1 Human 6.0 pIC50 ~ 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 447 5 1 6 6.4 CSc1nc2c(s1)c1sc(nc1cc2)NC(=O)C(c1ccccc1)c1ccccc1 22634634


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
49802029 104821 5 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 104821 5 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
66644128 104822 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 104822 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
49802029 104821 5 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 104821 5 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
66644128 104822 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 104822 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
1051 1427 56 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
4289 1427 56 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
445580 1427 56 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
57417355 1427 56 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
CHEMBL367149 1427 56 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
DB03756 1427 56 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
3174 1540 61 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
3362 1540 61 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
446284 1540 61 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
CHEMBL460026 1540 61 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
DB00159 1540 61 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
3391 155 17 None - 1 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
3416 155 17 None - 1 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
5283159 155 17 None - 1 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
CHEMBL18028 155 17 None - 1 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988