Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 5280878 | 99809 | 24 | None | 2 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL288943 | 99809 | 24 | None | 2 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/acs.jmedchem.1c01078 | ||
| 3352 | 2339 | 25 | None | -575 | 4 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| 5280879 | 2339 | 25 | None | -575 | 4 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| 5863 | 2339 | 25 | None | -575 | 4 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL509456 | 2339 | 25 | None | -575 | 4 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| 49863644 | 15140 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 498 | 13 | 1 | 5 | 6.1 | O=C(O)COc1ccc(F)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213847 | 15140 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 498 | 13 | 1 | 5 | 6.1 | O=C(O)COc1ccc(F)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 49863643 | 15139 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 480 | 13 | 1 | 5 | 5.9 | O=C(O)COc1ccccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213846 | 15139 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 480 | 13 | 1 | 5 | 5.9 | O=C(O)COc1ccccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 49863685 | 15144 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 471 | 13 | 1 | 6 | 5.4 | N#CCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccccc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213918 | 15144 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 471 | 13 | 1 | 6 | 5.4 | N#CCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccccc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 3354 | 2337 | 24 | None | -74 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| 5280493 | 2337 | 24 | None | -74 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL451509 | 2337 | 24 | None | -74 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| DB08855 | 2337 | 24 | None | -74 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| 46919026 | 15143 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 505 | 13 | 1 | 6 | 6.1 | N#CCOc1cc(C(=O)O)ccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213917 | 15143 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 505 | 13 | 1 | 6 | 6.1 | N#CCOc1cc(C(=O)O)ccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 1836 | 2554 | 56 | None | -10 | 15 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | ||
| 3340 | 2554 | 56 | None | -10 | 15 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | ||
| 5281040 | 2554 | 56 | None | -10 | 15 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL787 | 2554 | 56 | None | -10 | 15 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | ||
| DB00471 | 2554 | 56 | None | -10 | 15 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | ||
| 9829145 | 118822 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 555 | 12 | 2 | 4 | 8.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL344180 | 118822 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 555 | 12 | 2 | 4 | 8.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 44360643 | 30672 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 559 | 12 | 2 | 5 | 7.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL139757 | 30672 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 559 | 12 | 2 | 5 | 7.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 122183753 | 121700 | 0 | None | 3 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597618 | 121700 | 0 | None | 3 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 2855 | 4069 | 100 | None | 1 | 5 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | ||
| 3322 | 4069 | 100 | None | 1 | 5 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | ||
| 5717 | 4069 | 100 | None | 1 | 5 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 5 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | ||
| DB00549 | 4069 | 100 | None | 1 | 5 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | ||
| 122183752 | 121699 | 0 | None | 17 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597617 | 121699 | 0 | None | 17 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 44360674 | 118066 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 569 | 12 | 2 | 4 | 8.3 | CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL341603 | 118066 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 569 | 12 | 2 | 4 | 8.3 | CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/j.bmc.2010.06.047 | ||
| 122183751 | 121698 | 0 | None | 1 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 543 | 10 | 2 | 4 | 6.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597616 | 121698 | 0 | None | 1 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 543 | 10 | 2 | 4 | 6.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 15291446 | 34968 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 541 | 12 | 2 | 4 | 7.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL143515 | 34968 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 541 | 12 | 2 | 4 | 7.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 44360585 | 118587 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 569 | 12 | 2 | 4 | 8.6 | CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL342705 | 118587 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 569 | 12 | 2 | 4 | 8.6 | CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/j.bmc.2010.06.047 | ||
| 66739117 | 121680 | 0 | None | 9 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 573 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597535 | 121680 | 0 | None | 9 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 573 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 11261220 | 117415 | 0 | None | 5 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 539 | 13 | 2 | 7 | 5.6 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403186 | 117415 | 0 | None | 5 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 539 | 13 | 2 | 7 | 5.6 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 122183684 | 121672 | 0 | None | 7 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 559 | 14 | 2 | 4 | 7.7 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597527 | 121672 | 0 | None | 7 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 559 | 14 | 2 | 4 | 7.7 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 122183758 | 121706 | 0 | None | 19 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597623 | 121706 | 0 | None | 19 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 11398820 | 117284 | 0 | None | -1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 556 | 13 | 3 | 8 | 4.7 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401689 | 117284 | 0 | None | -1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 556 | 13 | 3 | 8 | 4.7 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 2237 | 3113 | 73 | None | -14 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | ||
| 3634 | 3113 | 73 | None | -14 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | ||
| 4887 | 3113 | 73 | None | -14 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL21333 | 3113 | 73 | None | -14 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | ||
| DB01411 | 3113 | 73 | None | -14 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | ||
| 122183689 | 121677 | 0 | None | 1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4cc(F)c(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597532 | 121677 | 0 | None | 1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4cc(F)c(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 44360637 | 118055 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 571 | 15 | 2 | 4 | 8.8 | CCCCc1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)ccc1C | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL341547 | 118055 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 571 | 15 | 2 | 4 | 8.8 | CCCCc1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)ccc1C | 10.1016/j.bmc.2010.06.047 | ||
| 122183682 | 121670 | 0 | None | 2 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 565 | 14 | 2 | 4 | 7.1 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597525 | 121670 | 0 | None | 2 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 565 | 14 | 2 | 4 | 7.1 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| 122183690 | 121679 | 0 | None | 6 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 557 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597534 | 121679 | 0 | None | 6 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 557 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 46835000 | 121716 | 0 | None | 1 | 3 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597633 | 121716 | 0 | None | 1 | 3 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 23124563 | 114526 | 0 | None | 630 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 546 | 12 | 3 | 6 | 4.4 | O=C(O)CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342952 | 114526 | 0 | None | 630 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 546 | 12 | 3 | 6 | 4.4 | O=C(O)CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 44352406 | 21314 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL131611 | 21314 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 11713438 | 121667 | 0 | None | 3 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597522 | 121667 | 0 | None | 3 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| 46834997 | 121707 | 0 | None | 1 | 3 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597624 | 121707 | 0 | None | 1 | 3 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 87131159 | 121678 | 0 | None | 1 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597533 | 121678 | 0 | None | 1 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 46830962 | 121717 | 16 | None | 3 | 3 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597634 | 121717 | 16 | None | 3 | 3 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 122183755 | 121703 | 0 | None | 7 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597620 | 121703 | 0 | None | 7 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 10839186 | 119202 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 502 | 5 | 1 | 6 | 5.4 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ncc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL34740 | 119202 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 502 | 5 | 1 | 6 | 5.4 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ncc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 10766366 | 13217 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 459 | 7 | 2 | 5 | 5.8 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11921 | 13217 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 459 | 7 | 2 | 5 | 5.8 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| 10646529 | 10293 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 435 | 6 | 2 | 4 | 6.0 | Cc1cc(C(=O)O)c(O)c(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11625 | 10293 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 435 | 6 | 2 | 4 | 6.0 | Cc1cc(C(=O)O)c(O)c(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 49863895 | 15192 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 448 | 7 | 3 | 5 | 5.1 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2ccc(OCc3nc4ccccc4[nH]3)cc2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214416 | 15192 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 448 | 7 | 3 | 5 | 5.1 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2ccc(OCc3nc4ccccc4[nH]3)cc2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| 9890153 | 161968 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 453 | 4 | 1 | 4 | 6.5 | O=C(O)c1cc(Cl)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL416769 | 161968 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 453 | 4 | 1 | 4 | 6.5 | O=C(O)c1cc(Cl)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 122183763 | 121713 | 0 | None | 4 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2c(F)ccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597630 | 121713 | 0 | None | 4 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2c(F)ccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 11191817 | 114529 | 1 | None | -3 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 11191817 | 114529 | 1 | None | -3 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342955 | 114529 | 1 | None | -3 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3342955 | 114529 | 1 | None | -3 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 5059 | 204638 | 37 | None | 2 | 3 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL8747 | 204638 | 37 | None | 2 | 3 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 10764782 | 162189 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 424 | 5 | 1 | 6 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ncc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL417135 | 162189 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 424 | 5 | 1 | 6 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ncc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 5059 | 204638 | 37 | None | 2 | 3 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL8747 | 204638 | 37 | None | 2 | 3 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 11626955 | 151279 | 0 | None | -18 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 471 | 7 | 2 | 8 | 4.6 | CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(C(F)(F)F)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3965244 | 151279 | 0 | None | -18 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 471 | 7 | 2 | 8 | 4.6 | CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(C(F)(F)F)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 127043617 | 139859 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c2c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3808608 | 139859 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c2c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 10792471 | 116207 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 535 | 5 | 1 | 5 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccc(Cl)cc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL33729 | 116207 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 535 | 5 | 1 | 5 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccc(Cl)cc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 11853184 | 117419 | 2 | None | 2 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3403190 | 117419 | 2 | None | 2 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | ||
| 122183754 | 121701 | 0 | None | 7 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597619 | 121701 | 0 | None | 7 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 23124629 | 114528 | 0 | None | 74 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 574 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342954 | 114528 | 0 | None | 74 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 574 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 127043233 | 139950 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 508 | 7 | 2 | 4 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809628 | 139950 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 508 | 7 | 2 | 4 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 11307317 | 114533 | 0 | None | -194 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342959 | 114533 | 0 | None | -194 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 14650410 | 189605 | 11 | None | 6 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 265 | 4 | 1 | 3 | 3.3 | OCc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5174405 | 189605 | 11 | None | 6 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 265 | 4 | 1 | 3 | 3.3 | OCc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 44352282 | 117949 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 526 | 9 | 1 | 5 | 5.5 | CN(CCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL341172 | 117949 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 526 | 9 | 1 | 5 | 5.5 | CN(CCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10765224 | 119305 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 433 | 4 | 1 | 4 | 6.2 | Cc1cc(C(=O)O)c2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL34835 | 119305 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 433 | 4 | 1 | 4 | 6.2 | Cc1cc(C(=O)O)c2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 118716774 | 114524 | 0 | None | 281 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 488 | 9 | 2 | 5 | 4.5 | CC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342950 | 114524 | 0 | None | 281 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 488 | 9 | 2 | 5 | 4.5 | CC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 11853184 | 117419 | 2 | None | 2 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403190 | 117419 | 2 | None | 2 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 49863972 | 15219 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 504 | 9 | 2 | 4 | 6.0 | C[C@@H](C(=O)NCc1ccc(CC(=O)O)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214642 | 15219 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 504 | 9 | 2 | 4 | 6.0 | C[C@@H](C(=O)NCc1ccc(CC(=O)O)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 23124775 | 114531 | 0 | None | 2 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 560 | 15 | 3 | 6 | 5.6 | O=C(O)CCCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342957 | 114531 | 0 | None | 2 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 560 | 15 | 3 | 6 | 5.6 | O=C(O)CCCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 23124623 | 114532 | 0 | None | -19 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 518 | 12 | 3 | 6 | 4.5 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342958 | 114532 | 0 | None | -19 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 518 | 12 | 3 | 6 | 4.5 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 59599515 | 147615 | 0 | None | 10 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 421 | 9 | 2 | 6 | 5.0 | CCCc1c(OCc2ccc(Oc3ccc(C(=O)O)cn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3935529 | 147615 | 0 | None | 10 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 421 | 9 | 2 | 6 | 5.0 | CCCc1c(OCc2ccc(Oc3ccc(C(=O)O)cn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 2855 | 4069 | 100 | None | 1 | 5 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
| 3322 | 4069 | 100 | None | 1 | 5 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
| 5717 | 4069 | 100 | None | 1 | 5 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 5 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
| DB00549 | 4069 | 100 | None | 1 | 5 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
| 135430849 | 12921 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 449 | 7 | 2 | 7 | 4.6 | O=C(/C=C/c1ccc(OCc2ccc3ccccc3n2)cc1)c1cc(-c2nn[nH]n2)ccc1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11899 | 12921 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 449 | 7 | 2 | 7 | 4.6 | O=C(/C=C/c1ccc(OCc2ccc3ccccc3n2)cc1)c1cc(-c2nn[nH]n2)ccc1O | 10.1016/j.bmc.2010.06.047 | ||
| 49863945 | 15214 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 479 | 7 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2CO)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214582 | 15214 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 479 | 7 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2CO)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10764001 | 9936 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 409 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1C(=O)/C=C/c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11509 | 9936 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 409 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1C(=O)/C=C/c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 11690196 | 142234 | 0 | None | -4 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 416 | 7 | 2 | 7 | 4.5 | CC(=O)c1ccc(OCc2ccc(Oc3cccc(-c4nn[nH]n4)c3)cc2)c(C)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3892611 | 142234 | 0 | None | -4 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 416 | 7 | 2 | 7 | 4.5 | CC(=O)c1ccc(OCc2ccc(Oc3cccc(-c4nn[nH]n4)c3)cc2)c(C)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 59599580 | 152184 | 0 | None | -8 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 471 | 7 | 2 | 8 | 4.6 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(C(F)(F)F)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3973048 | 152184 | 0 | None | -8 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 471 | 7 | 2 | 8 | 4.6 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(C(F)(F)F)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 49863766 | 15166 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 645 | 11 | 2 | 7 | 6.1 | COc1ccccc1S(=O)(=O)NC(=O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214096 | 15166 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 645 | 11 | 2 | 7 | 6.1 | COc1ccccc1S(=O)(=O)NC(=O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 118716775 | 114525 | 0 | None | 34 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 502 | 10 | 2 | 5 | 4.9 | CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342951 | 114525 | 0 | None | 34 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 502 | 10 | 2 | 5 | 4.9 | CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 59599475 | 148626 | 0 | None | -1 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 421 | 7 | 2 | 8 | 3.7 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(F)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3943547 | 148626 | 0 | None | -1 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 421 | 7 | 2 | 8 | 3.7 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(F)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 127043243 | 139937 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2c(Cl)cccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809483 | 139937 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2c(Cl)cccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 122183762 | 121712 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cc(F)cc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597629 | 121712 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cc(F)cc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 49863872 | 15181 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 480 | 7 | 2 | 6 | 4.5 | O=C(O)c1cc(=O)c2cccc(C(=O)NCc3ccc(OCc4ccc5ccccc5n4)cc3)c2o1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214353 | 15181 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 480 | 7 | 2 | 6 | 4.5 | O=C(O)c1cc(=O)c2cccc(C(=O)NCc3ccc(OCc4ccc5ccccc5n4)cc3)c2o1 | 10.1016/j.bmc.2010.06.047 | ||
| 127043241 | 139945 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(Cl)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809556 | 139945 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(Cl)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 10767627 | 108619 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 497 | 4 | 1 | 4 | 6.6 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL32136 | 108619 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 497 | 4 | 1 | 4 | 6.6 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 10574284 | 116472 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL33871 | 116472 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 122183756 | 121704 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597621 | 121704 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 11398475 | 114538 | 4 | None | -19 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342964 | 114538 | 4 | None | -19 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 10790119 | 11062 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 459 | 7 | 2 | 5 | 5.8 | O=C(O)c1cc(Cl)c(O)c(C(=O)/C=C/c2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11785 | 11062 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 459 | 7 | 2 | 5 | 5.8 | O=C(O)c1cc(Cl)c(O)c(C(=O)/C=C/c2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10787157 | 113609 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 400 | 3 | 0 | 4 | 6.1 | N#Cc1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL33276 | 113609 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 400 | 3 | 0 | 4 | 6.1 | N#Cc1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 15291450 | 167797 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 501 | 12 | 2 | 4 | 7.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccccn2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL434445 | 167797 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 501 | 12 | 2 | 4 | 7.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccccn2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 118728613 | 117287 | 0 | None | 2 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 488 | 12 | 2 | 5 | 5.4 | O=C(O)CCCN1CCOc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401692 | 117287 | 0 | None | 2 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 488 | 12 | 2 | 5 | 5.4 | O=C(O)CCCN1CCOc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 49863907 | 15198 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 658 | 9 | 2 | 8 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214477 | 15198 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 658 | 9 | 2 | 8 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | ||
| 46835000 | 121716 | 0 | None | -1 | 3 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597633 | 121716 | 0 | None | -1 | 3 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 46834997 | 121707 | 0 | None | -1 | 3 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597624 | 121707 | 0 | None | -1 | 3 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 122183688 | 121676 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)c(F)cc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597531 | 121676 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)c(F)cc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 58725448 | 191637 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 583 | 11 | 1 | 3 | 10.0 | CC(C)(C)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5205127 | 191637 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 583 | 11 | 1 | 3 | 10.0 | CC(C)(C)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 15291441 | 118082 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 557 | 15 | 2 | 4 | 8.5 | CCCCc1cccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL341657 | 118082 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 557 | 15 | 2 | 4 | 8.5 | CCCCc1cccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/j.bmc.2010.06.047 | ||
| 122183687 | 121675 | 0 | None | -2 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 579 | 14 | 2 | 4 | 7.4 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597530 | 121675 | 0 | None | -2 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 579 | 14 | 2 | 4 | 7.4 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 46830677 | 121714 | 0 | None | 1 | 3 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597631 | 121714 | 0 | None | 1 | 3 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 9804436 | 20439 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1ccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL130846 | 20439 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1ccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 15291439 | 118950 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 543 | 13 | 2 | 4 | 8.0 | CCc1ccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL345093 | 118950 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 543 | 13 | 2 | 4 | 8.0 | CCc1ccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C | 10.1016/j.bmc.2010.06.047 | ||
| 46830677 | 121714 | 0 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597631 | 121714 | 0 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 122183683 | 121671 | 0 | None | 4 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 543 | 14 | 2 | 4 | 7.2 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597526 | 121671 | 0 | None | 4 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 543 | 14 | 2 | 4 | 7.2 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 59599565 | 144782 | 0 | None | 2 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3cc(-c4nn[nH]n4)ccn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3913281 | 144782 | 0 | None | 2 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3cc(-c4nn[nH]n4)ccn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 159289 | 101595 | 14 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 333 | 5 | 2 | 7 | 2.5 | COc1ccc2sc(C(=O)Nc3nnn[nH]3)c(OC(C)C)c2c1 | 10.1021/jm00083a023 | ||
| CHEMBL302045 | 101595 | 14 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 333 | 5 | 2 | 7 | 2.5 | COc1ccc2sc(C(=O)Nc3nnn[nH]3)c(OC(C)C)c2c1 | 10.1021/jm00083a023 | ||
| 59599568 | 145517 | 0 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3918914 | 145517 | 0 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 10649046 | 9668 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 499 | 6 | 2 | 4 | 6.5 | O=C(O)c1cc(Br)cc(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11349 | 9668 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 499 | 6 | 2 | 4 | 6.5 | O=C(O)c1cc(Br)cc(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| 44352288 | 116844 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 477 | 10 | 1 | 4 | 7.1 | O=C(O)c1ccc(CCCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL339716 | 116844 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 477 | 10 | 1 | 4 | 7.1 | O=C(O)c1ccc(CCCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 28775506 | 190047 | 6 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 265 | 4 | 1 | 3 | 3.3 | OCc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5181326 | 190047 | 6 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 265 | 4 | 1 | 3 | 3.3 | OCc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/acs.jmedchem.1c01078 | ||
| 49863608 | 15135 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 517 | 7 | 2 | 5 | 6.2 | Cc1cc(COc2ccc(/C=C/C(=O)c3cc(Br)cc(C(=O)O)c3O)cc2)nc2ccccc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213780 | 15135 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 517 | 7 | 2 | 5 | 6.2 | Cc1cc(COc2ccc(/C=C/C(=O)c3cc(Br)cc(C(=O)O)c3O)cc2)nc2ccccc12 | 10.1016/j.bmc.2010.06.047 | ||
| 127043242 | 139920 | 0 | None | 3981 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)ccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809333 | 139920 | 0 | None | 3981 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)ccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 11227280 | 117285 | 0 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 609 | 14 | 3 | 8 | 3.8 | CS(=O)(=O)NC(=O)C1CN(CCCC(=O)O)c2cccc(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)c2O1 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401690 | 117285 | 0 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 609 | 14 | 3 | 8 | 3.8 | CS(=O)(=O)NC(=O)C1CN(CCCC(=O)O)c2cccc(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)c2O1 | 10.1016/j.bmc.2015.03.011 | ||
| 159289 | 101595 | 14 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 333 | 5 | 2 | 7 | 2.5 | COc1ccc2sc(C(=O)Nc3nnn[nH]3)c(OC(C)C)c2c1 | 10.1021/jm00083a023 | ||
| CHEMBL302045 | 101595 | 14 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 333 | 5 | 2 | 7 | 2.5 | COc1ccc2sc(C(=O)Nc3nnn[nH]3)c(OC(C)C)c2c1 | 10.1021/jm00083a023 | ||
| 2237 | 3113 | 73 | None | -14 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
| 3634 | 3113 | 73 | None | -14 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
| 4887 | 3113 | 73 | None | -14 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL21333 | 3113 | 73 | None | -14 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
| DB01411 | 3113 | 73 | None | -14 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
| 128355 | 3612 | 27 | None | 1 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm960088k | ||
| 3329 | 3612 | 27 | None | 1 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm960088k | ||
| CHEMBL18132 | 3612 | 27 | None | 1 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm960088k | ||
| 11455387 | 117416 | 0 | None | -77 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 531 | 14 | 2 | 6 | 5.6 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403187 | 117416 | 0 | None | -77 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 531 | 14 | 2 | 6 | 5.6 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 11596869 | 143105 | 0 | None | 8 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 417 | 7 | 2 | 8 | 3.9 | CC(=O)c1ccc(OCc2ccc(Oc3cc(-c4nn[nH]n4)ccn3)cc2)c(C)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3899832 | 143105 | 0 | None | 8 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 417 | 7 | 2 | 8 | 3.9 | CC(=O)c1ccc(OCc2ccc(Oc3cc(-c4nn[nH]n4)ccn3)cc2)c(C)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 127043248 | 139860 | 0 | None | 1819 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2[nH]c(C(=O)O)c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c2c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3808613 | 139860 | 0 | None | 1819 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2[nH]c(C(=O)O)c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c2c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 122183760 | 121709 | 0 | None | 2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597626 | 121709 | 0 | None | 2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 44360895 | 34582 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 597 | 13 | 2 | 4 | 8.7 | CCc1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)ccc1C(F)(F)F | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL143115 | 34582 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 597 | 13 | 2 | 4 | 8.7 | CCc1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)ccc1C(F)(F)F | 10.1016/j.bmc.2010.06.047 | ||
| 118729614 | 117417 | 0 | None | 1 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 541 | 14 | 2 | 6 | 6.0 | O=C(O)CCCn1cc(C(=O)O)c(=O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403188 | 117417 | 0 | None | 1 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 541 | 14 | 2 | 6 | 6.0 | O=C(O)CCCn1cc(C(=O)O)c(=O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 10502162 | 110983 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3ccc(/C=C/c4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL32764 | 110983 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3ccc(/C=C/c4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 14774173 | 189289 | 3 | None | 1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 279 | 4 | 1 | 3 | 3.5 | O=C(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5169385 | 189289 | 3 | None | 1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 279 | 4 | 1 | 3 | 3.5 | O=C(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 127043049 | 139879 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 561 | 6 | 3 | 3 | 8.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3808880 | 139879 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 561 | 6 | 3 | 3 | 8.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 23124716 | 114535 | 0 | None | -18 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 534 | 13 | 3 | 7 | 4.3 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342961 | 114535 | 0 | None | -18 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 534 | 13 | 3 | 7 | 4.3 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 46830961 | 121711 | 0 | None | 1 | 3 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597628 | 121711 | 0 | None | 1 | 3 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 122183681 | 121669 | 0 | None | 7 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 545 | 14 | 2 | 4 | 7.4 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4cccc(Cl)c4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597524 | 121669 | 0 | None | 7 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 545 | 14 | 2 | 4 | 7.4 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4cccc(Cl)c4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| 10074704 | 164753 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 500 | 8 | 2 | 6 | 5.1 | O=C(NCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL423333 | 164753 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 500 | 8 | 2 | 6 | 5.1 | O=C(NCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 68695885 | 121668 | 0 | None | 7 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 511 | 14 | 2 | 4 | 6.7 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597523 | 121668 | 0 | None | 7 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 511 | 14 | 2 | 4 | 6.7 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| 46830961 | 121711 | 0 | None | -1 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597628 | 121711 | 0 | None | -1 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 44352452 | 18759 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 540 | 9 | 2 | 5 | 5.9 | CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL128641 | 18759 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 540 | 9 | 2 | 5 | 5.9 | CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 44352450 | 19279 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL129866 | 19279 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10576732 | 10147 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 481 | 11 | 1 | 5 | 6.6 | CCCCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11609 | 10147 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 481 | 11 | 1 | 5 | 6.6 | CCCCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 118716776 | 114334 | 0 | None | 12 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 516 | 11 | 2 | 5 | 5.3 | CCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3341770 | 114334 | 0 | None | 12 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 516 | 11 | 2 | 5 | 5.3 | CCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 23124741 | 114534 | 0 | None | -1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 520 | 12 | 3 | 7 | 3.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342960 | 114534 | 0 | None | -1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 520 | 12 | 3 | 7 | 3.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 10597634 | 10425 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 409 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1C(=O)/C=C/c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11687 | 10425 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 409 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1C(=O)/C=C/c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10553494 | 108634 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL32138 | 108634 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 1836 | 2554 | 56 | None | -10 | 15 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
| 3340 | 2554 | 56 | None | -10 | 15 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
| 5281040 | 2554 | 56 | None | -10 | 15 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL787 | 2554 | 56 | None | -10 | 15 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
| DB00471 | 2554 | 56 | None | -10 | 15 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
| 127043048 | 139985 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 532 | 6 | 1 | 3 | 8.6 | O=C(/C=C/c1c[nH]c2cc(Cl)cc(Cl)c12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3810142 | 139985 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 532 | 6 | 1 | 3 | 8.6 | O=C(/C=C/c1c[nH]c2cc(Cl)cc(Cl)c12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 11284237 | 114536 | 0 | None | -1 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 548 | 14 | 3 | 7 | 4.7 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342962 | 114536 | 0 | None | -1 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 548 | 14 | 3 | 7 | 4.7 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 59599459 | 148897 | 0 | None | -1 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3ncccc3-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3945882 | 148897 | 0 | None | -1 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3ncccc3-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 49863609 | 15137 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 376 | 7 | 2 | 4 | 4.6 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2ccc(OCC3=CCCC=C3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213782 | 15137 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 376 | 7 | 2 | 4 | 4.6 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2ccc(OCC3=CCCC=C3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 59599545 | 146626 | 0 | None | -3 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 437 | 7 | 2 | 8 | 4.2 | CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(Cl)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3927834 | 146626 | 0 | None | -3 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 437 | 7 | 2 | 8 | 4.2 | CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(Cl)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 10597232 | 11208 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 402 | 5 | 1 | 4 | 5.9 | N#Cc1ccc(O)c(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11793 | 11208 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 402 | 5 | 1 | 4 | 5.9 | N#Cc1ccc(O)c(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 59599538 | 144512 | 0 | None | 1 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3ccc(-c4nn[nH]n4)cn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3911282 | 144512 | 0 | None | 1 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3ccc(-c4nn[nH]n4)cn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 127043236 | 139902 | 0 | None | 660 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 467 | 5 | 3 | 3 | 6.5 | O=C(O)c1[nH]c2ccccc2c1C(=O)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809164 | 139902 | 0 | None | 660 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 467 | 5 | 3 | 3 | 6.5 | O=C(O)c1[nH]c2ccccc2c1C(=O)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 11353238 | 117414 | 0 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 541 | 14 | 2 | 7 | 5.2 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403185 | 117414 | 0 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 541 | 14 | 2 | 7 | 5.2 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 49863809 | 15179 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1cccc(CC(=O)O)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214219 | 15179 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1cccc(CC(=O)O)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 127043247 | 139887 | 0 | None | 1995 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 529 | 6 | 3 | 3 | 7.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(F)cc(F)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3808968 | 139887 | 0 | None | 1995 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 529 | 6 | 3 | 3 | 7.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(F)cc(F)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 10324292 | 15145 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 517 | 5 | 2 | 6 | 5.8 | O=C(O)c1cc(Br)cc2c(=O)c(O)c(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213919 | 15145 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 517 | 5 | 2 | 6 | 5.8 | O=C(O)c1cc(Br)cc2c(=O)c(O)c(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 44352484 | 21288 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 450 | 8 | 2 | 6 | 3.9 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL131582 | 21288 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 450 | 8 | 2 | 6 | 3.9 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 10651746 | 99429 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 640 | 7 | 1 | 7 | 6.5 | O=C(NS(=O)(=O)c1ccccc1)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL285994 | 99429 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 640 | 7 | 1 | 7 | 6.5 | O=C(NS(=O)(=O)c1ccccc1)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 59599555 | 153014 | 0 | None | -1 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3ncccc3-c3nn[nH]n3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3980125 | 153014 | 0 | None | -1 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3ncccc3-c3nn[nH]n3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 13626863 | 189529 | 2 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 4 | 0 | 4 | 3.6 | COC(=O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5173307 | 189529 | 2 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 4 | 0 | 4 | 3.6 | COC(=O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 49863922 | 15205 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 630 | 9 | 2 | 7 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(OCc3ccc4ccc(C)cc4n3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214531 | 15205 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 630 | 9 | 2 | 7 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(OCc3ccc4ccc(C)cc4n3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | ||
| 49863921 | 15204 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | C[C@@H](Cc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214530 | 15204 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | C[C@@H](Cc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 122183685 | 121673 | 0 | None | 1 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 525 | 14 | 2 | 4 | 7.0 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4ccccc4)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597528 | 121673 | 0 | None | 1 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 525 | 14 | 2 | 4 | 7.0 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4ccccc4)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 46830963 | 121715 | 0 | None | 1 | 3 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597632 | 121715 | 0 | None | 1 | 3 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 2237 | 3113 | 73 | None | -14 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | ||
| 3634 | 3113 | 73 | None | -14 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | ||
| 4887 | 3113 | 73 | None | -14 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL21333 | 3113 | 73 | None | -14 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | ||
| DB01411 | 3113 | 73 | None | -14 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | ||
| 44352294 | 162889 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1cccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL419796 | 162889 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1cccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 44360752 | 118819 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 557 | 13 | 2 | 4 | 8.6 | Cc1ccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL344169 | 118819 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 557 | 13 | 2 | 4 | 8.6 | Cc1ccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/j.bmc.2010.06.047 | ||
| 10436360 | 15136 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 510 | 9 | 1 | 7 | 5.2 | CN(C)CCOc1c(-c2ccc(OCc3ccc4ccccc4n3)cc2)oc2c(C(=O)O)cccc2c1=O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213781 | 15136 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 510 | 9 | 1 | 7 | 5.2 | CN(C)CCOc1c(-c2ccc(OCc3ccc4ccccc4n3)cc2)oc2c(C(=O)O)cccc2c1=O | 10.1016/j.bmc.2010.06.047 | ||
| 57109 | 83070 | 18 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm960088k | ||
| CHEMBL22016 | 83070 | 18 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm960088k | ||
| 10598159 | 113939 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL33329 | 113939 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10836133 | 13604 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1cccc(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11950 | 13604 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1cccc(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| 44360808 | 32427 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 545 | 13 | 3 | 5 | 6.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc(C(=O)O)cn2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL141300 | 32427 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 545 | 13 | 3 | 5 | 6.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc(C(=O)O)cn2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10053523 | 15146 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 559 | 8 | 1 | 6 | 6.8 | CCCOc1c(-c2cccc(OCc3ccc4ccccc4n3)c2)oc2c(C(=O)O)cc(Br)cc2c1=O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213920 | 15146 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 559 | 8 | 1 | 6 | 6.8 | CCCOc1c(-c2cccc(OCc3ccc4ccccc4n3)c2)oc2c(C(=O)O)cc(Br)cc2c1=O | 10.1016/j.bmc.2010.06.047 | ||
| 44352142 | 18665 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 454 | 10 | 2 | 4 | 5.2 | O=C(O)CCCc1ccc(C(=O)NCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL128151 | 18665 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 454 | 10 | 2 | 4 | 5.2 | O=C(O)CCCc1ccc(C(=O)NCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 118716777 | 114530 | 0 | None | 3 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342956 | 114530 | 0 | None | 3 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 3381 | 582 | 24 | None | -17 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1021/ml500298y | ||
| 5311015 | 582 | 24 | None | -17 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1021/ml500298y | ||
| CHEMBL285954 | 582 | 24 | None | -17 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1021/ml500298y | ||
| 10600630 | 12504 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 475 | 8 | 2 | 7 | 5.1 | O=C(/C=C/c1cccc(/C=C/c2ccc3ccccc3n2)c1)c1cc(OCc2nn[nH]n2)ccc1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11870 | 12504 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 475 | 8 | 2 | 7 | 5.1 | O=C(/C=C/c1cccc(/C=C/c2ccc3ccccc3n2)c1)c1cc(OCc2nn[nH]n2)ccc1O | 10.1016/j.bmc.2010.06.047 | ||
| 10836131 | 11163 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11791 | 11163 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 122183686 | 121674 | 0 | None | -3 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 555 | 15 | 2 | 5 | 7.0 | COc1ccccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597529 | 121674 | 0 | None | -3 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 555 | 15 | 2 | 5 | 7.0 | COc1ccccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 118716772 | 114522 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1ccc2c(c1)OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
| CHEMBL3342948 | 114522 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1ccc2c(c1)OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
| 59599552 | 147771 | 0 | None | -12 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 437 | 7 | 2 | 8 | 4.2 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(Cl)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3936830 | 147771 | 0 | None | -12 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 437 | 7 | 2 | 8 | 4.2 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(Cl)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 59599616 | 145731 | 0 | None | 1 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3cccc(-c4nn[nH]n4)c3)nc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3920609 | 145731 | 0 | None | 1 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3cccc(-c4nn[nH]n4)c3)nc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 118729615 | 117418 | 0 | None | -6 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 542 | 15 | 2 | 7 | 6.0 | O=C(O)CCCOc1nc2cccc(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)c2nc1C(=O)O | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403189 | 117418 | 0 | None | -6 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 542 | 15 | 2 | 7 | 6.0 | O=C(O)CCCOc1nc2cccc(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)c2nc1C(=O)O | 10.1016/j.bmc.2015.03.011 | ||
| 49863923 | 15206 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 626 | 8 | 2 | 6 | 7.1 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(/C=C/c3ccc4ccc(C)cc4n3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214532 | 15206 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 626 | 8 | 2 | 6 | 7.1 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(/C=C/c3ccc4ccc(C)cc4n3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | ||
| 122183757 | 121705 | 0 | None | 10 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597622 | 121705 | 0 | None | 10 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 127043618 | 139995 | 0 | None | 2570 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1cccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c12 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3810210 | 139995 | 0 | None | 2570 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1cccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c12 | 10.1021/acsmedchemlett.5b00482 | ||
| 10649109 | 118946 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL34507 | 118946 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 11387037 | 114537 | 0 | None | 1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342963 | 114537 | 0 | None | 1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 168280068 | 190595 | 0 | None | -5 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 293 | 6 | 0 | 3 | 4.6 | CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5189181 | 190595 | 0 | None | -5 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 293 | 6 | 0 | 3 | 4.6 | CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 136127005 | 15191 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 438 | 7 | 3 | 7 | 3.9 | O=C(/C=C/c1ccc(OCc2nc3ccccc3[nH]2)cc1)c1cc(-c2nnn[nH]2)ccc1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214415 | 15191 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 438 | 7 | 3 | 7 | 3.9 | O=C(/C=C/c1ccc(OCc2nc3ccccc3[nH]2)cc1)c1cc(-c2nnn[nH]2)ccc1O | 10.1016/j.bmc.2010.06.047 | ||
| 11796528 | 113654 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL33294 | 113654 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 90871050 | 114521 | 0 | None | 85 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1cccc2c1OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
| CHEMBL3342947 | 114521 | 0 | None | 85 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1cccc2c1OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
| 49863641 | 15138 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 358 | 4 | 1 | 4 | 5.0 | O=C(O)c1cccc2c(=O)cc(-c3ccc(Oc4ccccc4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213844 | 15138 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 358 | 4 | 1 | 4 | 5.0 | O=C(O)c1cccc2c(=O)cc(-c3ccc(Oc4ccccc4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 122183761 | 121710 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 613 | 15 | 2 | 4 | 8.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597627 | 121710 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 613 | 15 | 2 | 4 | 8.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 127043237 | 139890 | 0 | None | 870 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 495 | 7 | 3 | 3 | 6.8 | O=C(CCc1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3808985 | 139890 | 0 | None | 870 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 495 | 7 | 3 | 3 | 6.8 | O=C(CCc1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 11249398 | 117281 | 0 | None | -1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 519 | 14 | 2 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(OCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401686 | 117281 | 0 | None | -1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 519 | 14 | 2 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(OCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 46830962 | 121717 | 16 | None | -3 | 3 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597634 | 121717 | 16 | None | -3 | 3 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 10647443 | 13016 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 455 | 6 | 2 | 4 | 6.4 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11905 | 13016 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 455 | 6 | 2 | 4 | 6.4 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| 10717271 | 98146 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL276879 | 98146 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 59599577 | 144352 | 0 | None | 1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3909995 | 144352 | 0 | None | 1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 10532372 | 15147 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 658 | 8 | 1 | 7 | 8.2 | O=C(O)c1cc(Br)cc2c(=O)c(OCc3ccc4ccccc4n3)c(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213921 | 15147 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 658 | 8 | 1 | 7 | 8.2 | O=C(O)c1cc(Br)cc2c(=O)c(OCc3ccc4ccccc4n3)c(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 122183759 | 121708 | 0 | None | 3 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597625 | 121708 | 0 | None | 3 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 127043252 | 139861 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 576 | 7 | 2 | 4 | 8.3 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3808623 | 139861 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 576 | 7 | 2 | 4 | 8.3 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 127043053 | 139998 | 0 | None | 537 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cccc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3810290 | 139998 | 0 | None | 537 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cccc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 44352148 | 18623 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 449 | 8 | 1 | 4 | 6.4 | O=C(O)c1ccc(COCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL127842 | 18623 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 449 | 8 | 1 | 4 | 6.4 | O=C(O)c1ccc(COCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 44352326 | 20648 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3cc(OCc4ccc5ccccc5n4)ccc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL131025 | 20648 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3cc(OCc4ccc5ccccc5n4)ccc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 46830963 | 121715 | 0 | None | -1 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597632 | 121715 | 0 | None | -1 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 127043244 | 139905 | 0 | None | 5888 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 511 | 6 | 3 | 3 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(F)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809189 | 139905 | 0 | None | 5888 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 511 | 6 | 3 | 3 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(F)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 23124680 | 117282 | 0 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 515 | 13 | 2 | 5 | 5.8 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401687 | 117282 | 0 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 515 | 13 | 2 | 5 | 5.8 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 23124664 | 117286 | 0 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 671 | 15 | 3 | 8 | 5.3 | O=C(O)CCCN1CC(C(=O)NS(=O)(=O)c2ccccc2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401691 | 117286 | 0 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 671 | 15 | 3 | 8 | 5.3 | O=C(O)CCCN1CC(C(=O)NS(=O)(=O)c2ccccc2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 59599576 | 142007 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 421 | 9 | 2 | 6 | 5.0 | CCCc1c(OCc2cccc(Oc3cc(C(=O)O)ccn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3890848 | 142007 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 421 | 9 | 2 | 6 | 5.0 | CCCc1c(OCc2cccc(Oc3cc(C(=O)O)ccn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 118729613 | 117413 | 0 | None | -1 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 518 | 13 | 3 | 6 | 4.8 | O=C(O)CCCN1CC(CO)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403184 | 117413 | 0 | None | -1 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 518 | 13 | 3 | 6 | 4.8 | O=C(O)CCCN1CC(CO)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 44352103 | 116190 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccccc1CC(=O)O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL337195 | 116190 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccccc1CC(=O)O | 10.1016/j.bmc.2010.06.047 | ||
| 11191817 | 114529 | 1 | None | -3 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3342955 | 114529 | 1 | None | -3 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | ||
| 49863579 | 15132 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 517 | 5 | 2 | 6 | 5.8 | O=C(O)c1cc(Br)cc2c(=O)c(O)c(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213720 | 15132 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 517 | 5 | 2 | 6 | 5.8 | O=C(O)c1cc(Br)cc2c(=O)c(O)c(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 23124707 | 117283 | 0 | None | -5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 517 | 14 | 2 | 5 | 5.4 | O=C(O)CCCN1CC(C(=O)O)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401688 | 117283 | 0 | None | -5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 517 | 14 | 2 | 5 | 5.4 | O=C(O)CCCN1CC(C(=O)O)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 118716773 | 114523 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1ccc2c(c1)NCC(C(=O)O)O2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
| CHEMBL3342949 | 114523 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1ccc2c(c1)NCC(C(=O)O)O2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
| 44352397 | 20996 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 504 | 7 | 2 | 8 | 4.0 | O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c(=O)cc(-c3nn[nH]n3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL131287 | 20996 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 504 | 7 | 2 | 8 | 4.0 | O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c(=O)cc(-c3nn[nH]n3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 127043050 | 139909 | 0 | None | 6456 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 493 | 6 | 3 | 3 | 6.9 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809230 | 139909 | 0 | None | 6456 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 493 | 6 | 3 | 3 | 6.9 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 44352186 | 21866 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 478 | 7 | 2 | 5 | 6.4 | O=C(Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)OCc1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL132167 | 21866 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 478 | 7 | 2 | 5 | 6.4 | O=C(Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)OCc1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 44352154 | 164474 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL422609 | 164474 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10472005 | 16650 | 0 | None | - | 1 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 333 | 5 | 0 | 4 | 4.3 | COC(=O)COc1cccc(/C=C/c2ccc3cc(C)ccc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL124741 | 16650 | 0 | None | - | 1 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 333 | 5 | 0 | 4 | 4.3 | COC(=O)COc1cccc(/C=C/c2ccc3cc(C)ccc3n2)c1 | 10.1021/jm00099a011 | ||
| 168288290 | 190760 | 0 | None | -95 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 307 | 6 | 0 | 3 | 5.0 | CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5192002 | 190760 | 0 | None | -95 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 307 | 6 | 0 | 3 | 5.0 | CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 54677430 | 114520 | 0 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 510 | 8 | 2 | 7 | 5.1 | CCN(CC)C(=O)/C=C(\C)c1ccc2oc(C(=O)c3ccc(C#N)cc3)c(NC(=O)/C(C#N)=C(/C)O)c2c1 | 10.1021/ml500298y | ||
| CHEMBL3342946 | 114520 | 0 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 510 | 8 | 2 | 7 | 5.1 | CCN(CC)C(=O)/C=C(\C)c1ccc2oc(C(=O)c3ccc(C#N)cc3)c(NC(=O)/C(C#N)=C(/C)O)c2c1 | 10.1021/ml500298y | ||
| 14626814 | 183757 | 0 | None | - | 0 | Human | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 561 | 8 | 2 | 7 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL48435 | 183757 | 0 | None | - | 0 | Human | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 561 | 8 | 2 | 7 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 145979664 | 166043 | 0 | None | - | 0 | Human | 10.0 | pKd | = | 10 | Functional | ChEMBL | 595 | 8 | 2 | 7 | 6.0 | COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4280282 | 166043 | 0 | None | - | 0 | Human | 10.0 | pKd | = | 10 | Functional | ChEMBL | 595 | 8 | 2 | 7 | 6.0 | COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 22848867 | 14591 | 0 | None | - | 1 | Guinea pig | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206453 | 14591 | 0 | None | - | 1 | Guinea pig | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL275357 | 14591 | 0 | None | - | 1 | Guinea pig | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 14626863 | 167348 | 1 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 574 | 8 | 3 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL431348 | 167348 | 1 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 574 | 8 | 3 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 22848869 | 14430 | 0 | None | - | 1 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204695 | 14430 | 0 | None | - | 1 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15306 | 14430 | 0 | None | - | 1 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 145987347 | 166604 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 608 | 8 | 3 | 6 | 6.0 | COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4290919 | 166604 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 608 | 8 | 3 | 6 | 6.0 | COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 10346 | 2522 | 40 | None | 4 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 5281888 | 2522 | 40 | None | 4 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15177 | 2522 | 40 | None | 4 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 22848881 | 14596 | 0 | None | - | 1 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206471 | 14596 | 0 | None | - | 1 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL277533 | 14596 | 0 | None | - | 1 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269759 | 43924 | 0 | None | - | 1 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 587 | 13 | 2 | 4 | 9.2 | CCC[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15161 | 43924 | 0 | None | - | 1 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 587 | 13 | 2 | 4 | 9.2 | CCC[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 145981186 | 165971 | 1 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 574 | 8 | 3 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4279086 | 165971 | 1 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 574 | 8 | 3 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 19794942 | 99914 | 0 | None | - | 0 | Guinea pig | 7.0 | pKd | = | 7 | Functional | ChEMBL | 520 | 16 | 2 | 5 | 6.7 | O=C(O)CCC(/C=C/Cc1ccc(OCCCCOc2ccccc2)cc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL289880 | 99914 | 0 | None | - | 0 | Guinea pig | 7.0 | pKd | = | 7 | Functional | ChEMBL | 520 | 16 | 2 | 5 | 6.7 | O=C(O)CCC(/C=C/Cc1ccc(OCCCCOc2ccccc2)cc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 145987301 | 166534 | 0 | None | - | 0 | Human | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 592 | 8 | 3 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2cccc(F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4289768 | 166534 | 0 | None | - | 0 | Human | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 592 | 8 | 3 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2cccc(F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 145992748 | 166473 | 0 | None | - | 0 | Human | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 588 | 8 | 3 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4288574 | 166473 | 0 | None | - | 0 | Human | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 588 | 8 | 3 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 19794942 | 99914 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 520 | 16 | 2 | 5 | 6.7 | O=C(O)CCC(/C=C/Cc1ccc(OCCCCOc2ccccc2)cc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL289880 | 99914 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 520 | 16 | 2 | 5 | 6.7 | O=C(O)CCC(/C=C/Cc1ccc(OCCCCOc2ccccc2)cc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 145994218 | 166772 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 642 | 8 | 3 | 6 | 6.4 | COc1cc(C(=O)NS(=O)(=O)c2cccc(C(F)(F)F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4294239 | 166772 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 642 | 8 | 3 | 6 | 6.4 | COc1cc(C(=O)NS(=O)(=O)c2cccc(C(F)(F)F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 22848883 | 14590 | 0 | None | - | 1 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206448 | 14590 | 0 | None | - | 1 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL274913 | 14590 | 0 | None | - | 1 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 105007 | 96653 | 24 | None | - | 1 | Guinea pig | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00388a028 | ||
| CHEMBL267475 | 96653 | 24 | None | - | 1 | Guinea pig | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00388a028 | ||
| CHEMBL267976 | 96653 | 24 | None | - | 1 | Guinea pig | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00388a028 | ||
| 145992231 | 166350 | 0 | None | - | 0 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 642 | 8 | 3 | 6 | 6.7 | COc1cc(C(=O)NS(=O)(=O)c2cc(Cl)cc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4286347 | 166350 | 0 | None | - | 0 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 642 | 8 | 3 | 6 | 6.7 | COc1cc(C(=O)NS(=O)(=O)c2cc(Cl)cc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 9829784 | 101403 | 6 | None | - | 0 | Guinea pig | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 582 | 7 | 2 | 7 | 5.9 | C[C@H]1Oc2ccc(OCc3nc4cc(F)ccc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1 | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL300701 | 101403 | 6 | None | - | 0 | Guinea pig | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 582 | 7 | 2 | 7 | 5.9 | C[C@H]1Oc2ccc(OCc3nc4cc(F)ccc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1 | 10.1016/s0960-894x(98)00654-4 | ||
| 2237 | 3113 | 73 | None | 14 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | ||
| 3634 | 3113 | 73 | None | 14 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | ||
| 4887 | 3113 | 73 | None | 14 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL21333 | 3113 | 73 | None | 14 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | ||
| DB01411 | 3113 | 73 | None | 14 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | ||
| 9956127 | 168815 | 7 | None | - | 0 | Guinea pig | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 465 | 6 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2O)c1 | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL442150 | 168815 | 7 | None | - | 0 | Guinea pig | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 465 | 6 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2O)c1 | 10.1016/s0960-894x(98)00654-4 | ||
| 2855 | 4069 | 100 | None | -1 | 5 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | ||
| 3322 | 4069 | 100 | None | -1 | 5 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | ||
| 5717 | 4069 | 100 | None | -1 | 5 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL603 | 4069 | 100 | None | -1 | 5 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | ||
| DB00549 | 4069 | 100 | None | -1 | 5 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | ||
| 9874234 | 113558 | 0 | None | - | 0 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 644 | 8 | 2 | 8 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL332680 | 113558 | 0 | None | - | 0 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 644 | 8 | 2 | 8 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | ||
| 9830780 | 13220 | 3 | None | - | 0 | Guinea pig | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 636 | 8 | 2 | 7 | 6.8 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL119214 | 13220 | 3 | None | - | 0 | Guinea pig | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 636 | 8 | 2 | 7 | 6.8 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | ||
| 44345841 | 14356 | 0 | None | - | 0 | Guinea pig | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 648 | 7 | 2 | 7 | 7.1 | CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cc(NS(=O)(=O)C(F)(F)F)ccc1Cl | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL120200 | 14356 | 0 | None | - | 0 | Guinea pig | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 648 | 7 | 2 | 7 | 7.1 | CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cc(NS(=O)(=O)C(F)(F)F)ccc1Cl | 10.1016/s0960-894x(98)00654-4 | ||
| 44346037 | 112915 | 0 | None | - | 0 | Guinea pig | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 632 | 7 | 2 | 6 | 7.4 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(/C=C/c3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL331884 | 112915 | 0 | None | - | 0 | Guinea pig | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 632 | 7 | 2 | 6 | 7.4 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(/C=C/c3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | ||
| 44345821 | 112850 | 0 | None | - | 0 | Guinea pig | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 614 | 7 | 2 | 7 | 6.5 | CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1 | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL331747 | 112850 | 0 | None | - | 0 | Guinea pig | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 614 | 7 | 2 | 7 | 6.5 | CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1 | 10.1016/s0960-894x(98)00654-4 | ||
| 53394034 | 581 | 17 | None | -21 | 2 | Human | 6.4 | pA2 | = | 6.4 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | ||
| 6196 | 581 | 17 | None | -21 | 2 | Human | 6.4 | pA2 | = | 6.4 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | ||
| CHEMBL3342945 | 581 | 17 | None | -21 | 2 | Human | 6.4 | pA2 | = | 6.4 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | ||
| 10002 | 3804 | 0 | None | - | 1 | Human | 8.7 | pA2 | = | 8.7 | Functional | Guide to Pharmacology | 568 | 8 | 3 | 6 | 5.5 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)Nc1ccccc1)C)C(=O)NS(=O)(=O)c1ccccc1 | 29878767 | ||
| 134611898 | 3804 | 0 | None | - | 1 | Human | 8.7 | pA2 | = | 8.7 | Functional | Guide to Pharmacology | 568 | 8 | 3 | 6 | 5.5 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)Nc1ccccc1)C)C(=O)NS(=O)(=O)c1ccccc1 | 29878767 | ||
| 6194 | 2792 | 0 | None | -61 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | 639 | 26 | 7 | 8 | 3.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)NC | 21078884 | ||
| 73755185 | 2792 | 0 | None | -61 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | 639 | 26 | 7 | 8 | 3.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)NC | 21078884 | ||
| 3352 | 2339 | 25 | None | -575 | 4 | Human | 6.4 | pEC50 | = | 6.4 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | ||
| 5280879 | 2339 | 25 | None | -575 | 4 | Human | 6.4 | pEC50 | = | 6.4 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | ||
| 5863 | 2339 | 25 | None | -575 | 4 | Human | 6.4 | pEC50 | = | 6.4 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | ||
| CHEMBL509456 | 2339 | 25 | None | -575 | 4 | Human | 6.4 | pEC50 | = | 6.4 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | ||
| 3352 | 2339 | 25 | None | -575 | 4 | Human | 6.7 | pEC50 | = | 6.7 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| 5280879 | 2339 | 25 | None | -575 | 4 | Human | 6.7 | pEC50 | = | 6.7 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| 5863 | 2339 | 25 | None | -575 | 4 | Human | 6.7 | pEC50 | = | 6.7 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| CHEMBL509456 | 2339 | 25 | None | -575 | 4 | Human | 6.7 | pEC50 | = | 6.7 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| 3352 | 2339 | 25 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10462554 | ||
| 3352 | 2339 | 25 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
| 3352 | 2339 | 25 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
| 5280879 | 2339 | 25 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10462554 | ||
| 5280879 | 2339 | 25 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
| 5280879 | 2339 | 25 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
| 5863 | 2339 | 25 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10462554 | ||
| 5863 | 2339 | 25 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
| 5863 | 2339 | 25 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
| CHEMBL509456 | 2339 | 25 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10462554 | ||
| CHEMBL509456 | 2339 | 25 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
| CHEMBL509456 | 2339 | 25 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
| 3354 | 2337 | 24 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10462554 | ||
| 3354 | 2337 | 24 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | ||
| 3354 | 2337 | 24 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
| 5280493 | 2337 | 24 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10462554 | ||
| 5280493 | 2337 | 24 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | ||
| 5280493 | 2337 | 24 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
| CHEMBL451509 | 2337 | 24 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10462554 | ||
| CHEMBL451509 | 2337 | 24 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | ||
| CHEMBL451509 | 2337 | 24 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
| DB08855 | 2337 | 24 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10462554 | ||
| DB08855 | 2337 | 24 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | ||
| DB08855 | 2337 | 24 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
| 3354 | 2337 | 24 | None | -74 | 4 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| 5280493 | 2337 | 24 | None | -74 | 4 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| CHEMBL451509 | 2337 | 24 | None | -74 | 4 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| DB08855 | 2337 | 24 | None | -74 | 4 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| 3353 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3353 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| 3353 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
| 3353 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
| 3353 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 17558309 | ||
| 3353 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
| 3412 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3412 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| 3412 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
| 3412 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
| 3412 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 17558309 | ||
| 3412 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
| 6435286 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 6435286 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| 6435286 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
| 6435286 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
| 6435286 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 17558309 | ||
| 6435286 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
| CHEMBL1521056 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| CHEMBL1521056 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| CHEMBL1521056 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
| CHEMBL1521056 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
| CHEMBL1521056 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 17558309 | ||
| CHEMBL1521056 | 2338 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
| 3353 | 2338 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| 3412 | 2338 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| 6435286 | 2338 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| CHEMBL1521056 | 2338 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| 3353 | 2338 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3412 | 2338 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 6435286 | 2338 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| CHEMBL1521056 | 2338 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3353 | 2338 | 0 | None | -4 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3412 | 2338 | 0 | None | -4 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 6435286 | 2338 | 0 | None | -4 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| CHEMBL1521056 | 2338 | 0 | None | -4 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 10581 | 968 | 0 | None | 1819 | 2 | Human | 9.0 | pIC50 | < | 9 | Functional | Guide to Pharmacology | 587 | 17 | 2 | 7 | 5.4 | O=C(CN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCc1ccccc1)C(=O)O)CCCC(=O)O | 31811124 | ||
| 145996520 | 968 | 0 | None | 1819 | 2 | Human | 9.0 | pIC50 | < | 9 | Functional | Guide to Pharmacology | 587 | 17 | 2 | 7 | 5.4 | O=C(CN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCc1ccccc1)C(=O)O)CCCC(=O)O | 31811124 | ||
| 2237 | 3113 | 73 | None | -14 | 3 | Human | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| 3634 | 3113 | 73 | None | -14 | 3 | Human | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| 4887 | 3113 | 73 | None | -14 | 3 | Human | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| CHEMBL21333 | 3113 | 73 | None | -14 | 3 | Human | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| DB01411 | 3113 | 73 | None | -14 | 3 | Human | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| 10582 | 976 | 0 | None | -194 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | 573 | 17 | 2 | 6 | 6.2 | OC(=O)CCCCN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCCc1ccccc1)C(=O)O | 31811124 | ||
| 145996521 | 976 | 0 | None | -194 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | 573 | 17 | 2 | 6 | 6.2 | OC(=O)CCCCN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCCc1ccccc1)C(=O)O | 31811124 | ||
| 2237 | 3113 | 73 | None | -14 | 3 | Human | 10.0 | pIC50 | = | 10 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| 3634 | 3113 | 73 | None | -14 | 3 | Human | 10.0 | pIC50 | = | 10 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| 4887 | 3113 | 73 | None | -14 | 3 | Human | 10.0 | pIC50 | = | 10 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| CHEMBL21333 | 3113 | 73 | None | -14 | 3 | Human | 10.0 | pIC50 | = | 10 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| DB01411 | 3113 | 73 | None | -14 | 3 | Human | 10.0 | pIC50 | = | 10 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| 3381 | 582 | 24 | None | -17 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
| 5311015 | 582 | 24 | None | -17 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
| CHEMBL285954 | 582 | 24 | None | -17 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
| 3381 | 582 | 24 | None | -17 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
| 5311015 | 582 | 24 | None | -17 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
| CHEMBL285954 | 582 | 24 | None | -17 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
| 3354 | 2337 | 24 | None | -74 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| 5280493 | 2337 | 24 | None | -74 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| CHEMBL451509 | 2337 | 24 | None | -74 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| DB08855 | 2337 | 24 | None | -74 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| 3352 | 2339 | 25 | None | -575 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| 5280879 | 2339 | 25 | None | -575 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| 5863 | 2339 | 25 | None | -575 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| CHEMBL509456 | 2339 | 25 | None | -575 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| 3334 | 3098 | 7 | None | 48 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | ||
| 60842 | 3098 | 7 | None | 48 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | ||
| CHEMBL22776 | 3098 | 7 | None | 48 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | ||
| 2855 | 4069 | 100 | None | 1 | 5 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
| 3322 | 4069 | 100 | None | 1 | 5 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
| 5717 | 4069 | 100 | None | 1 | 5 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 5 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
| DB00549 | 4069 | 100 | None | 1 | 5 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
| 3353 | 2338 | 0 | None | -4 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| 3412 | 2338 | 0 | None | -4 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| 6435286 | 2338 | 0 | None | -4 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| CHEMBL1521056 | 2338 | 0 | None | -4 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| 2237 | 3113 | 73 | None | -14 | 3 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | ||
| 2237 | 3113 | 73 | None | -14 | 3 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| 3634 | 3113 | 73 | None | -14 | 3 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | ||
| 3634 | 3113 | 73 | None | -14 | 3 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| 4887 | 3113 | 73 | None | -14 | 3 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | ||
| 4887 | 3113 | 73 | None | -14 | 3 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| CHEMBL21333 | 3113 | 73 | None | -14 | 3 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | ||
| CHEMBL21333 | 3113 | 73 | None | -14 | 3 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| DB01411 | 3113 | 73 | None | -14 | 3 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | ||
| DB01411 | 3113 | 73 | None | -14 | 3 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| 3334 | 3098 | 7 | None | 48 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | ||
| 60842 | 3098 | 7 | None | 48 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | ||
| CHEMBL22776 | 3098 | 7 | None | 48 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | ||
| 1836 | 2554 | 56 | None | -10 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| 3340 | 2554 | 56 | None | -10 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| 5281040 | 2554 | 56 | None | -10 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| CHEMBL787 | 2554 | 56 | None | -10 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| DB00471 | 2554 | 56 | None | -10 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| 2855 | 4069 | 100 | None | 1 | 5 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| 3322 | 4069 | 100 | None | 1 | 5 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| 5717 | 4069 | 100 | None | 1 | 5 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 5 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| DB00549 | 4069 | 100 | None | 1 | 5 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| 1836 | 2554 | 56 | None | -10 | 15 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | ||
| 1836 | 2554 | 56 | None | -10 | 15 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| 3340 | 2554 | 56 | None | -10 | 15 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | ||
| 3340 | 2554 | 56 | None | -10 | 15 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| 5281040 | 2554 | 56 | None | -10 | 15 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | ||
| 5281040 | 2554 | 56 | None | -10 | 15 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| CHEMBL787 | 2554 | 56 | None | -10 | 15 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | ||
| CHEMBL787 | 2554 | 56 | None | -10 | 15 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| DB00471 | 2554 | 56 | None | -10 | 15 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | ||
| DB00471 | 2554 | 56 | None | -10 | 15 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| 2855 | 4069 | 100 | None | 1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | ||
| 2855 | 4069 | 100 | None | 1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| 3322 | 4069 | 100 | None | 1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | ||
| 3322 | 4069 | 100 | None | 1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| 5717 | 4069 | 100 | None | 1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | ||
| 5717 | 4069 | 100 | None | 1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| DB00549 | 4069 | 100 | None | 1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | ||
| DB00549 | 4069 | 100 | None | 1 | 5 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| 6193 | 3921 | 33 | None | -1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | ||
| 6509849 | 3921 | 33 | None | -1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | ||
| CHEMBL280481 | 3921 | 33 | None | -1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | ||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 2237 | 3113 | 73 | None | 4 | 3 | Guinea pig | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| 3634 | 3113 | 73 | None | 4 | 3 | Guinea pig | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| 4887 | 3113 | 73 | None | 4 | 3 | Guinea pig | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL21333 | 3113 | 73 | None | 4 | 3 | Guinea pig | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| DB01411 | 3113 | 73 | None | 4 | 3 | Guinea pig | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| 15236851 | 112302 | 0 | None | - | 0 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.8 | CC[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL330649 | 112302 | 0 | None | - | 0 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.8 | CC[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| 22848867 | 14591 | 0 | None | - | 1 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206453 | 14591 | 0 | None | - | 1 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL275357 | 14591 | 0 | None | - | 1 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 9829145 | 118822 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 555 | 12 | 2 | 4 | 8.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL344180 | 118822 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 555 | 12 | 2 | 4 | 8.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 44329532 | 205908 | 0 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | C[C@@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@H](C)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL95234 | 205908 | 0 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | C[C@@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@H](C)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| 10099896 | 206671 | 13 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.2 | CC(C)(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL99775 | 206671 | 13 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.2 | CC(C)(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/0960-894X(95)00023-M | ||
| 10074173 | 16430 | 0 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 486 | 11 | 2 | 5 | 5.9 | NC(=O)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL124095 | 16430 | 0 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 486 | 11 | 2 | 5 | 5.9 | NC(=O)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 22848867 | 14591 | 0 | None | - | 1 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206453 | 14591 | 0 | None | - | 1 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL275357 | 14591 | 0 | None | - | 1 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 15859376 | 206207 | 0 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | C[C@@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL96986 | 206207 | 0 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | C[C@@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| 44269827 | 14426 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 558 | 12 | 2 | 6 | 7.1 | O=C(O)CCSC(CCc1ccccc1-c1nc[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204691 | 14426 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 558 | 12 | 2 | 6 | 7.1 | O=C(O)CCSC(CCc1ccccc1-c1nc[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL14819 | 14426 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 558 | 12 | 2 | 6 | 7.1 | O=C(O)CCSC(CCc1ccccc1-c1nc[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44320022 | 105514 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.7 | CC(C)(O)c1ccc(CC[C@@H](SCC2(CC(=O)O)CC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)cc1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL313187 | 105514 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.7 | CC(C)(O)c1ccc(CC[C@@H](SCC2(CC(=O)O)CC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)cc1 | 10.1016/0960-894X(95)00448-3 | ||
| 15872197 | 203602 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 632 | 8 | 2 | 8 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL79366 | 203602 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 632 | 8 | 2 | 8 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 44213972 | 203670 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 694 | 9 | 2 | 8 | 7.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL79952 | 203670 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 694 | 9 | 2 | 8 | 7.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 44461050 | 204083 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 674 | 8 | 2 | 9 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N2CCOCC2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL83166 | 204083 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 674 | 8 | 2 | 9 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N2CCOCC2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 44269877 | 14792 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 601 | 13 | 1 | 8 | 7.2 | CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1208514 | 14792 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 601 | 13 | 1 | 8 | 7.2 | CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15232 | 14792 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 601 | 13 | 1 | 8 | 7.2 | CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269762 | 14429 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204694 | 14429 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15292 | 14429 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44269966 | 14432 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204697 | 14432 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15370 | 14432 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44360858 | 118793 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 583 | 12 | 2 | 4 | 8.7 | CC1(C)CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL343934 | 118793 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 583 | 12 | 2 | 4 | 8.7 | CC1(C)CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/s0960-894x(98)00051-1 | ||
| 22849291 | 107854 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.8 | CC(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL319802 | 107854 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.8 | CC(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/0960-894X(95)00023-M | ||
| 2855 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | ||
| 3322 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | ||
| 5717 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL603 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | ||
| DB00549 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | ||
| 22849284 | 206312 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | CC(S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(C)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL97576 | 206312 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | CC(S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(C)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| 15291446 | 34968 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 541 | 12 | 2 | 4 | 7.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL143515 | 34968 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 541 | 12 | 2 | 4 | 7.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 44269964 | 14602 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 590 | 14 | 2 | 5 | 7.7 | CCNC(=O)c1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206505 | 14602 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 590 | 14 | 2 | 5 | 7.7 | CCNC(=O)c1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL280310 | 14602 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 590 | 14 | 2 | 5 | 7.7 | CCNC(=O)c1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44360585 | 118587 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.6 | CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL342705 | 118587 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.6 | CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/s0960-894x(98)00051-1 | ||
| 44319718 | 105517 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2cccc(C3(O)CCC3)c2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL313195 | 105517 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2cccc(C3(O)CCC3)c2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 44270016 | 14428 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 562 | 13 | 2 | 5 | 7.1 | CCC(CSC(CCc1ccccc1C(N)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204693 | 14428 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 562 | 13 | 2 | 5 | 7.1 | CCC(CSC(CCc1ccccc1C(N)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15120 | 14428 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 562 | 13 | 2 | 5 | 7.1 | CCC(CSC(CCc1ccccc1C(N)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269966 | 14432 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204697 | 14432 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15370 | 14432 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44461124 | 104068 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 660 | 10 | 2 | 8 | 6.5 | CCN(CC)C(=O)n1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL310446 | 104068 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 660 | 10 | 2 | 8 | 6.5 | CCN(CC)C(=O)n1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1016/s0960-894x(98)00442-9 | ||
| 44213973 | 104936 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 604 | 8 | 3 | 8 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(N)=O)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL311868 | 104936 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 604 | 8 | 3 | 8 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(N)=O)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 10439506 | 203612 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 675 | 11 | 3 | 9 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)NCCN(C)C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL79479 | 203612 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 675 | 11 | 3 | 9 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)NCCN(C)C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 10372711 | 203650 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 722 | 12 | 3 | 8 | 7.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)NCCCc2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL79741 | 203650 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 722 | 12 | 3 | 8 | 7.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)NCCCc2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 1836 | 2554 | 56 | None | -1 | 15 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | ||
| 3340 | 2554 | 56 | None | -1 | 15 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | ||
| 5281040 | 2554 | 56 | None | -1 | 15 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | ||
| CHEMBL787 | 2554 | 56 | None | -1 | 15 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | ||
| DB00471 | 2554 | 56 | None | -1 | 15 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | ||
| 1836 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | ||
| 3340 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | ||
| 5281040 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL787 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | ||
| DB00471 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | ||
| 1836 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | ||
| 3340 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | ||
| 5281040 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | ||
| CHEMBL787 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | ||
| DB00471 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | ||
| 44288760 | 161630 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 561 | 13 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL416251 | 161630 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 561 | 13 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44269410 | 14421 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 525 | 13 | 2 | 4 | 8.3 | CC(CC[C@H](SCCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1204685 | 14421 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 525 | 13 | 2 | 4 | 8.3 | CC(CC[C@H](SCCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL14268 | 14421 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 525 | 13 | 2 | 4 | 8.3 | CC(CC[C@H](SCCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 9829365 | 14427 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204692 | 14427 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15035 | 14427 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 19767826 | 14599 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206492 | 14599 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL279630 | 14599 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44270023 | 43736 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 576 | 12 | 1 | 5 | 7.3 | CC(CSC(CCc1ccccc1C(=O)N(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15132 | 43736 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 576 | 12 | 1 | 5 | 7.3 | CC(CSC(CCc1ccccc1C(=O)N(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 9809348 | 204617 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL87337 | 204617 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 44360674 | 118066 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.3 | CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL341603 | 118066 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.3 | CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/s0960-894x(98)00051-1 | ||
| 44269954 | 14589 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206442 | 14589 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL274049 | 14589 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 22849285 | 205937 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.9 | CCC(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL95362 | 205937 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.9 | CCC(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| 15859377 | 205926 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | C[C@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL95317 | 205926 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | C[C@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| 44288760 | 161630 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 561 | 13 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL416251 | 161630 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 561 | 13 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44269347 | 14424 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1204689 | 14424 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL14451 | 14424 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44269378 | 14586 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1206432 | 14586 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL273343 | 14586 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44209267 | 14598 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 602 | 12 | 1 | 5 | 8.0 | O=C(O)CCSC(CCc1ccccc1C(=O)N1CCCCC1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206480 | 14598 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 602 | 12 | 1 | 5 | 8.0 | O=C(O)CCSC(CCc1ccccc1C(=O)N1CCCCC1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL278411 | 14598 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 602 | 12 | 1 | 5 | 8.0 | O=C(O)CCSC(CCc1ccccc1C(=O)N1CCCCC1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44270043 | 14431 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204696 | 14431 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15344 | 14431 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269762 | 14429 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204694 | 14429 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15292 | 14429 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44269954 | 14589 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206442 | 14589 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL274049 | 14589 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 19767826 | 14599 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206492 | 14599 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL279630 | 14599 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44360643 | 30672 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 559 | 12 | 2 | 5 | 7.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL139757 | 30672 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 559 | 12 | 2 | 5 | 7.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 44319717 | 161313 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2ccc(C3(O)CCC3)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL414885 | 161313 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2ccc(C3(O)CCC3)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 9985552 | 106736 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.9 | CC(C)(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL316688 | 106736 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.9 | CC(C)(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| 5280878 | 99809 | 24 | None | 2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmcl.2013.01.025 | ||
| CHEMBL288943 | 99809 | 24 | None | 2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmcl.2013.01.025 | ||
| 44288372 | 99677 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 617 | 14 | 2 | 5 | 9.3 | CC(CC(F)(F)F)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL287722 | 99677 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 617 | 14 | 2 | 5 | 9.3 | CC(CC(F)(F)F)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| 44319715 | 204422 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 597 | 12 | 2 | 5 | 8.9 | O=C(O)CC1(CS[C@H](CCc2ccccc2CO)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL86063 | 204422 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 597 | 12 | 2 | 5 | 8.9 | O=C(O)CC1(CS[C@H](CCc2ccccc2CO)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 15290709 | 106090 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 593 | 12 | 2 | 5 | 8.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(F)c(F)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL314237 | 106090 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 593 | 12 | 2 | 5 | 8.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(F)c(F)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 14325224 | 206252 | 5 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | CN(C)C(=O)CCS[C@@H](SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00172a025 | ||
| CHEMBL97257 | 206252 | 5 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | CN(C)C(=O)CCS[C@@H](SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00172a025 | ||
| 1836 | 2554 | 56 | None | -1 | 15 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | ||
| 3340 | 2554 | 56 | None | -1 | 15 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | ||
| 5281040 | 2554 | 56 | None | -1 | 15 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL787 | 2554 | 56 | None | -1 | 15 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | ||
| DB00471 | 2554 | 56 | None | -1 | 15 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | ||
| 10076489 | 206496 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | CC(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL98676 | 206496 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | CC(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| 10346 | 2522 | 40 | None | - | 1 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00099a011 | ||
| 5281888 | 2522 | 40 | None | - | 1 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00099a011 | ||
| CHEMBL15177 | 2522 | 40 | None | - | 1 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00099a011 | ||
| 44288159 | 163167 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 593 | 12 | 2 | 5 | 8.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(F)c(F)cc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL42051 | 163167 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 593 | 12 | 2 | 5 | 8.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(F)c(F)cc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44288695 | 168043 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 575 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43602 | 168043 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 575 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44269325 | 14592 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1206456 | 14592 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL275823 | 14592 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44269924 | 14597 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 587 | 13 | 2 | 7 | 7.2 | CCC(CSC(CCc1ccccc1-c1nn[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206475 | 14597 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 587 | 13 | 2 | 7 | 7.2 | CCC(CSC(CCc1ccccc1-c1nn[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL278210 | 14597 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 587 | 13 | 2 | 7 | 7.2 | CCC(CSC(CCc1ccccc1-c1nn[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 9829365 | 14427 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204692 | 14427 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15035 | 14427 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269329 | 14697 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1207565 | 14697 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL415981 | 14697 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44269759 | 43924 | 0 | None | - | 1 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 587 | 13 | 2 | 4 | 9.2 | CCC[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15161 | 43924 | 0 | None | - | 1 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 587 | 13 | 2 | 4 | 9.2 | CCC[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 45268321 | 193898 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 615 | 9 | 1 | 5 | 7.8 | O=C(O)c1ccccc1OCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL555048 | 193898 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 615 | 9 | 1 | 5 | 7.8 | O=C(O)c1ccccc1OCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 19767793 | 98508 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15513 | 98508 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL279773 | 98508 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44461163 | 4886 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 561 | 8 | 3 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL1048 | 4886 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 561 | 8 | 3 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 44460797 | 203444 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 611 | 9 | 2 | 7 | 6.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(F)F)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL78140 | 203444 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 611 | 9 | 2 | 7 | 6.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(F)F)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 15872199 | 203445 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 589 | 9 | 2 | 8 | 5.2 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C=O)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL78141 | 203445 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 589 | 9 | 2 | 8 | 5.2 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C=O)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 2237 | 3113 | 73 | None | 4 | 3 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | ||
| 3634 | 3113 | 73 | None | 4 | 3 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | ||
| 4887 | 3113 | 73 | None | 4 | 3 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | ||
| CHEMBL21333 | 3113 | 73 | None | 4 | 3 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | ||
| DB01411 | 3113 | 73 | None | 4 | 3 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | ||
| 44250106 | 193503 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL550456 | 193503 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288372 | 99677 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 617 | 14 | 2 | 5 | 9.3 | CC(CC(F)(F)F)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL287722 | 99677 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 617 | 14 | 2 | 5 | 9.3 | CC(CC(F)(F)F)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| 44269376 | 14425 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1204690 | 14425 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL14569 | 14425 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44361757 | 34189 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.5 | C[C@H](CS[C@@H](CCc1ccccc1CC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL142803 | 34189 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.5 | C[C@H](CS[C@@H](CCc1ccccc1CC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| 19767776 | 14698 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 542 | 12 | 1 | 4 | 8.1 | CCC(CSC(CCc1ccccc1C#N)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1207567 | 14698 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 542 | 12 | 1 | 4 | 8.1 | CCC(CSC(CCc1ccccc1C#N)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL416161 | 14698 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 542 | 12 | 1 | 4 | 8.1 | CCC(CSC(CCc1ccccc1C#N)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44270043 | 14431 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204696 | 14431 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15344 | 14431 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269865 | 14600 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206502 | 14600 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL280260 | 14600 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44320021 | 106617 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2ccccc2C2(O)CCC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL315973 | 106617 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2ccccc2C2(O)CCC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 44319783 | 106659 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 627 | 13 | 2 | 5 | 9.3 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL316170 | 106659 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 627 | 13 | 2 | 5 | 9.3 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 44360625 | 32820 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL141640 | 32820 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 15290705 | 106198 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL314340 | 106198 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 45271665 | 193643 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3c(F)cccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL551520 | 193643 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3c(F)cccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 45268226 | 194392 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 545 | 7 | 1 | 6 | 6.2 | Clc1ccc2ccc(/C=C/c3cccc(Cn4c5c(c6ccccc64)CCN(CCc4nnn[nH]4)C5)c3)nc2c1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL560522 | 194392 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 545 | 7 | 1 | 6 | 6.2 | Clc1ccc2ccc(/C=C/c3cccc(Cn4c5c(c6ccccc64)CCN(CCc4nnn[nH]4)C5)c3)nc2c1 | 10.1016/j.bmcl.2009.05.094 | ||
| 45269111 | 194660 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 5 | 1 | 4 | 6.1 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(C#Cc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL562383 | 194660 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 5 | 1 | 4 | 6.1 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(C#Cc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44269323 | 14420 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 539 | 13 | 2 | 4 | 8.7 | CC(C)(O)CCCSC(CCC(C)(C)CC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1204684 | 14420 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 539 | 13 | 2 | 4 | 8.7 | CC(C)(O)CCCSC(CCC(C)(C)CC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL14180 | 14420 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 539 | 13 | 2 | 4 | 8.7 | CC(C)(O)CCCSC(CCC(C)(C)CC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | ||
| 44269939 | 47721 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | CC(CCC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15500 | 47721 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | CC(CCC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 44288695 | 168043 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 575 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43602 | 168043 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 575 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44269368 | 14422 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 587 | 13 | 2 | 4 | 8.9 | CC(C)(O)c1ccccc1CS[C@@H](CCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1204687 | 14422 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 587 | 13 | 2 | 4 | 8.9 | CC(C)(O)c1ccccc1CS[C@@H](CCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL14408 | 14422 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 587 | 13 | 2 | 4 | 8.9 | CC(C)(O)c1ccccc1CS[C@@H](CCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | ||
| 44269880 | 14708 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1207684 | 14708 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL429975 | 14708 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 10346 | 2522 | 40 | None | - | 1 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| 5281888 | 2522 | 40 | None | - | 1 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL15177 | 2522 | 40 | None | - | 1 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| 44288569 | 99746 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 561 | 12 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCCC3)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL288369 | 99746 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 561 | 12 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCCC3)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44269383 | 14588 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 532 | 12 | 1 | 4 | 8.3 | CC(C)(CC[C@H](SCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1206441 | 14588 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 532 | 12 | 1 | 4 | 8.3 | CC(C)(CC[C@H](SCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL274038 | 14588 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 532 | 12 | 1 | 4 | 8.3 | CC(C)(CC[C@H](SCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44319992 | 204450 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 567 | 11 | 1 | 4 | 9.4 | O=C(O)CC1(CS[C@H](CCc2ccccc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL86302 | 204450 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 567 | 11 | 1 | 4 | 9.4 | O=C(O)CC1(CS[C@H](CCc2ccccc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 44250107 | 194184 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 539 | 7 | 1 | 4 | 7.0 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL558638 | 194184 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 539 | 7 | 1 | 4 | 7.0 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44360675 | 32557 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 555 | 12 | 2 | 4 | 8.2 | CC1CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL141405 | 32557 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 555 | 12 | 2 | 4 | 8.2 | CC1CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/s0960-894x(98)00051-1 | ||
| 44288430 | 100667 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 547 | 13 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL295281 | 100667 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 547 | 13 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 2855 | 4069 | 100 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| 3322 | 4069 | 100 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| 5717 | 4069 | 100 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| DB00549 | 4069 | 100 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| 2855 | 4069 | 100 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| 3322 | 4069 | 100 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| 5717 | 4069 | 100 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| DB00549 | 4069 | 100 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| 2855 | 4069 | 100 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | ||
| 3322 | 4069 | 100 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | ||
| 5717 | 4069 | 100 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | ||
| DB00549 | 4069 | 100 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | ||
| 44288716 | 161607 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 549 | 13 | 2 | 5 | 8.3 | CC(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL41620 | 161607 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 549 | 13 | 2 | 5 | 8.3 | CC(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| 44269345 | 14423 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1204688 | 14423 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL14450 | 14423 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 19767879 | 167066 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)CCSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL430147 | 167066 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)CCSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 9829999 | 204263 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3scc(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL84707 | 204263 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3scc(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 44274381 | 79607 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 540 | 17 | 3 | 6 | 6.8 | CCCCC/C=C/C/C=C\C=C\C=C\[C@@H](Sc1ccc2c(=O)cc(C(=O)O)oc2c1)[C@H](O)CCCC(=O)O | 10.1021/jm00108a001 | ||
| CHEMBL21286 | 79607 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 540 | 17 | 3 | 6 | 6.8 | CCCCC/C=C/C/C=C\C=C\C=C\[C@@H](Sc1ccc2c(=O)cc(C(=O)O)oc2c1)[C@H](O)CCCC(=O)O | 10.1021/jm00108a001 | ||
| 6518171 | 167733 | 49 | None | -4 | 8 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 495 | 12 | 2 | 6 | 4.9 | CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 | nan | ||
| CHEMBL434063 | 167733 | 49 | None | -4 | 8 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 495 | 12 | 2 | 6 | 4.9 | CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 | nan | ||
| 44288480 | 165412 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL42520 | 165412 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44288324 | 161213 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(C(F)(F)F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL41395 | 161213 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(C(F)(F)F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 45270816 | 195079 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 527 | 7 | 1 | 5 | 7.0 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3nc4cc(Cl)ccc4s3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL565228 | 195079 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 527 | 7 | 1 | 5 | 7.0 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3nc4cc(Cl)ccc4s3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 45270799 | 193369 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCC2C(C1)c1ccccc1N2Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL549431 | 193369 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCC2C(C1)c1ccccc1N2Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288249 | 158714 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 8.6 | Cc1sc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL40992 | 158714 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 8.6 | Cc1sc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/0960-894X(95)00265-U | ||
| 10051321 | 16725 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 491 | 12 | 2 | 6 | 5.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL125135 | 16725 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 491 | 12 | 2 | 6 | 5.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 44288613 | 157295 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 613 | 14 | 2 | 6 | 8.9 | COc1ccc(-c2csc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)n2)cc1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL40836 | 157295 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 613 | 14 | 2 | 6 | 8.9 | COc1ccc(-c2csc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)n2)cc1 | 10.1016/0960-894X(95)00265-U | ||
| 45268266 | 194322 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 535 | 6 | 1 | 5 | 7.1 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2ccc3oc(-c4ccc5ccc(Cl)cc5n4)cc3c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL559928 | 194322 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 535 | 6 | 1 | 5 | 7.1 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2ccc3oc(-c4ccc5ccc(Cl)cc5n4)cc3c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 15289799 | 98206 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 518 | 12 | 1 | 6 | 5.9 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL277332 | 98206 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 518 | 12 | 1 | 6 | 5.9 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 45273388 | 194048 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 537 | 8 | 1 | 4 | 7.1 | O=C(O)CCCN1CCC2c3ccccc3N(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL557105 | 194048 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 537 | 8 | 1 | 4 | 7.1 | O=C(O)CCCN1CCC2c3ccccc3N(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288614 | 96031 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 601 | 13 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL262391 | 96031 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 601 | 13 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44319586 | 204091 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 639 | 12 | 2 | 5 | 9.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(C2CC2c2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL83233 | 204091 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 639 | 12 | 2 | 5 | 9.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(C2CC2c2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 45273411 | 193234 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 565 | 9 | 1 | 5 | 7.3 | CCOc1cccc2c3c(n(Cc4cccc(/C=C/c5ccc6ccc(Cl)cc6n5)c4)c12)CCN(CCC(=O)O)C3 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL541010 | 193234 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 565 | 9 | 1 | 5 | 7.3 | CCOc1cccc2c3c(n(Cc4cccc(/C=C/c5ccc6ccc(Cl)cc6n5)c4)c12)CCN(CCC(=O)O)C3 | 10.1016/j.bmcl.2009.05.094 | ||
| 10744393 | 71120 | 0 | None | - | 1 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 514 | 8 | 2 | 5 | 4.7 | O=C(N[C@H](CN1CCC(OC2c3ccccc3CCc3ccccc32)CC1)C(=O)O)OCc1ccccc1 | 10.1021/jm058225d | ||
| CHEMBL196220 | 71120 | 0 | None | - | 1 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 514 | 8 | 2 | 5 | 4.7 | O=C(N[C@H](CN1CCC(OC2c3ccccc3CCc3ccccc32)CC1)C(=O)O)OCc1ccccc1 | 10.1021/jm058225d | ||
| 45268250 | 194650 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 551 | 8 | 1 | 5 | 6.9 | COc1ccc2c3c(n(Cc4cccc(/C=C/c5ccc6ccc(Cl)cc6n5)c4)c2c1)CCN(CCC(=O)O)C3 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL562324 | 194650 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 551 | 8 | 1 | 5 | 6.9 | COc1ccc2c3c(n(Cc4cccc(/C=C/c5ccc6ccc(Cl)cc6n5)c4)c2c1)CCN(CCC(=O)O)C3 | 10.1016/j.bmcl.2009.05.094 | ||
| 45270063 | 194748 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 549 | 9 | 1 | 4 | 7.7 | O=C(O)CCCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL562906 | 194748 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 549 | 9 | 1 | 4 | 7.7 | O=C(O)CCCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 45269186 | 195044 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 521 | 7 | 1 | 4 | 6.9 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL564954 | 195044 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 521 | 7 | 1 | 4 | 6.9 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 9829198 | 160759 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 557 | 12 | 2 | 5 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3ccccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL41230 | 160759 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 557 | 12 | 2 | 5 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3ccccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 10526098 | 99238 | 1 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970180w | ||
| CHEMBL284624 | 99238 | 1 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970180w | ||
| 10574284 | 116472 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970180w | ||
| CHEMBL33871 | 116472 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970180w | ||
| 45270876 | 193504 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 507 | 6 | 1 | 4 | 6.5 | O=C(O)CN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL550458 | 193504 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 507 | 6 | 1 | 4 | 6.5 | O=C(O)CN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 22848883 | 14590 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206448 | 14590 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL274913 | 14590 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44288589 | 100949 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 9.0 | CC(C)c1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)sc1Cl | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL297396 | 100949 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 9.0 | CC(C)c1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)sc1Cl | 10.1016/0960-894X(95)00265-U | ||
| 448537 | 159703 | 86 | None | -41 | 25 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | nan | ||
| CHEMBL411 | 159703 | 86 | None | -41 | 25 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | nan | ||
| 44288589 | 100949 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 9.0 | CC(C)c1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)sc1Cl | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL297396 | 100949 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 9.0 | CC(C)c1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)sc1Cl | 10.1016/0960-894X(95)00265-U | ||
| 2855 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | ||
| 3322 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | ||
| 5717 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL603 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | ||
| DB00549 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | ||
| 9853580 | 105668 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 756 | 10 | 2 | 8 | 9.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(c2ccccc2)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL313567 | 105668 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 756 | 10 | 2 | 8 | 9.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(c2ccccc2)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 44360640 | 31320 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)C(C)(C)CC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL140381 | 31320 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)C(C)(C)CC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 44288735 | 161628 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 8.5 | CC(C)(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL416249 | 161628 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 8.5 | CC(C)(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| 44269386 | 14700 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1207573 | 14700 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL416344 | 14700 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44361753 | 33720 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 11 | 1 | 4 | 8.0 | C[C@H](CS[C@@H](CCc1ccccc1C=O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL142395 | 33720 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 11 | 1 | 4 | 8.0 | C[C@H](CS[C@@H](CCc1ccccc1C=O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| 22848869 | 14430 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204695 | 14430 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15306 | 14430 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269865 | 14600 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206502 | 14600 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL280260 | 14600 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44319587 | 204371 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 629 | 13 | 2 | 6 | 9.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(OCc2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL85633 | 204371 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 629 | 13 | 2 | 6 | 9.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(OCc2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 44288714 | 154607 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 589 | 13 | 2 | 5 | 9.3 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL40213 | 154607 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 589 | 13 | 2 | 5 | 9.3 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44361755 | 35188 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 531 | 11 | 2 | 4 | 7.7 | C[C@H](CS[C@@H](CCc1cccc(CO)c1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL143788 | 35188 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 531 | 11 | 2 | 4 | 7.7 | C[C@H](CS[C@@H](CCc1cccc(CO)c1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| 44319872 | 204669 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 585 | 11 | 1 | 4 | 9.6 | O=C(O)CC1(CS[C@H](CCc2ccc(F)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL87696 | 204669 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 585 | 11 | 1 | 4 | 9.6 | O=C(O)CC1(CS[C@H](CCc2ccc(F)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 9985190 | 157627 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 556 | 11 | 1 | 6 | 6.2 | O=C(O)CCSC(SCCC(=O)N1CCOCC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL408753 | 157627 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 556 | 11 | 1 | 6 | 6.2 | O=C(O)CCSC(SCCC(=O)N1CCOCC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 44269370 | 14593 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 13 | 1 | 4 | 8.4 | CC(C)(CC[C@H](SCCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1206457 | 14593 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 13 | 1 | 4 | 8.4 | CC(C)(CC[C@H](SCCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL276036 | 14593 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 13 | 1 | 4 | 8.4 | CC(C)(CC[C@H](SCCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 1836 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| 3340 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| 5281040 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| CHEMBL787 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| DB00471 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| 1836 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | ||
| 3340 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | ||
| 5281040 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL787 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | ||
| DB00471 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | ||
| 15859378 | 111048 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | C[C@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@@H](C)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL327942 | 111048 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | C[C@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@@H](C)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| 44269352 | 14601 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1206504 | 14601 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL280298 | 14601 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 1836 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | ||
| 3340 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | ||
| 5281040 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL787 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | ||
| DB00471 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | ||
| 44319978 | 204361 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 645 | 11 | 1 | 4 | 10.2 | O=C(O)CC1(CS[C@H](CCc2ccccc2Br)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL85572 | 204361 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 645 | 11 | 1 | 4 | 10.2 | O=C(O)CC1(CS[C@H](CCc2ccccc2Br)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 10346 | 2522 | 40 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| 5281888 | 2522 | 40 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL15177 | 2522 | 40 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| 45269140 | 194513 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3cc(F)ccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL561381 | 194513 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3cc(F)ccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 15859367 | 35283 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.4 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL143874 | 35283 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.4 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| 44360644 | 30967 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 559 | 12 | 2 | 5 | 7.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCS3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL140058 | 30967 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 559 | 12 | 2 | 5 | 7.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCS3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 45272522 | 194112 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCC2c3ccccc3N(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL557850 | 194112 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCC2c3ccccc3N(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 22848883 | 14590 | 0 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206448 | 14590 | 0 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL274913 | 14590 | 0 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 14541296 | 193324 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 540 | 15 | 2 | 7 | 6.3 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(CCC)(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL54744 | 193324 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 540 | 15 | 2 | 7 | 6.3 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(CCC)(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 45268240 | 194539 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 555 | 7 | 1 | 4 | 7.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(Cl)c(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL561524 | 194539 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 555 | 7 | 1 | 4 | 7.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(Cl)c(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 128355 | 3612 | 27 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00108a001 | ||
| 3329 | 3612 | 27 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00108a001 | ||
| CHEMBL18132 | 3612 | 27 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00108a001 | ||
| 128355 | 3612 | 27 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00166a017 | ||
| 3329 | 3612 | 27 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00166a017 | ||
| CHEMBL18132 | 3612 | 27 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00166a017 | ||
| 13997664 | 60024 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 405 | 8 | 2 | 4 | 4.9 | CCCCCc1ccc(/C=C/C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL174483 | 60024 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 405 | 8 | 2 | 4 | 4.9 | CCCCCc1ccc(/C=C/C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/acs.jmedchem.6b01287 | ||
| 45270792 | 194697 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 523 | 8 | 1 | 4 | 6.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(CCc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL562575 | 194697 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 523 | 8 | 1 | 4 | 6.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(CCc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 10097610 | 14636 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 503 | 13 | 2 | 5 | 6.5 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL1207034 | 14636 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 503 | 13 | 2 | 5 | 6.5 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL339713 | 14636 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 503 | 13 | 2 | 5 | 6.5 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 45273491 | 194122 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 535 | 6 | 1 | 4 | 6.4 | O=C(O)CC(=O)N1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL557924 | 194122 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 535 | 6 | 1 | 4 | 6.4 | O=C(O)CC(=O)N1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 19930521 | 46596 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 516 | 12 | 1 | 5 | 6.1 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15405 | 46596 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 516 | 12 | 1 | 5 | 6.1 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 5352624 | 66903 | 40 | None | -4 | 5 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 340 | 4 | 1 | 2 | 5.4 | CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 | nan | ||
| CHEMBL18797 | 66903 | 40 | None | -4 | 5 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 340 | 4 | 1 | 2 | 5.4 | CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 | nan | ||
| 45270885 | 193933 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 585 | 7 | 1 | 4 | 7.9 | O=C(O)c1ccc(CN2CCc3c(c4ccccc4n3Cc3cccc(/C=C/c4ccc5cc(F)c(F)cc5n4)c3)C2)cc1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL555910 | 193933 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 585 | 7 | 1 | 4 | 7.9 | O=C(O)c1ccc(CN2CCc3c(c4ccccc4n3Cc3cccc(/C=C/c4ccc5cc(F)c(F)cc5n4)c3)C2)cc1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288196 | 168364 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 547 | 12 | 2 | 5 | 7.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCC3)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43874 | 168364 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 547 | 12 | 2 | 5 | 7.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCC3)c1 | 10.1016/0960-894X(95)00265-U | ||
| 9829423 | 32335 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 11 | 1 | 4 | 8.4 | CC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL141233 | 32335 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 11 | 1 | 4 | 8.4 | CC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| 10346 | 2522 | 40 | None | - | 1 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 5281888 | 2522 | 40 | None | - | 1 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15177 | 2522 | 40 | None | - | 1 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 6193 | 3921 | 33 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm960088k | ||
| 6509849 | 3921 | 33 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm960088k | ||
| CHEMBL280481 | 3921 | 33 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm960088k | ||
| 6193 | 3921 | 33 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| 6509849 | 3921 | 33 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL280481 | 3921 | 33 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| 6193 | 3921 | 33 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/acs.jmedchem.6b00472 | ||
| 6509849 | 3921 | 33 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/acs.jmedchem.6b00472 | ||
| CHEMBL280481 | 3921 | 33 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/acs.jmedchem.6b00472 | ||
| 14325224 | 206252 | 5 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | CN(C)C(=O)CCS[C@@H](SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00172a025 | ||
| CHEMBL97257 | 206252 | 5 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | CN(C)C(=O)CCS[C@@H](SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00172a025 | ||
| 44361773 | 32844 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 531 | 11 | 2 | 4 | 7.7 | C[C@H](CS[C@@H](CCc1ccccc1CO)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL141665 | 32844 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 531 | 11 | 2 | 4 | 7.7 | C[C@H](CS[C@@H](CCc1ccccc1CO)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| 6193 | 3921 | 33 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | ||
| 6509849 | 3921 | 33 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | ||
| CHEMBL280481 | 3921 | 33 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | ||
| 45273490 | 193858 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 561 | 8 | 1 | 4 | 7.7 | O=C(O)CC1(CN2CCc3c(c4ccccc4n3Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2)CC1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL554154 | 193858 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 561 | 8 | 1 | 4 | 7.7 | O=C(O)CC1(CN2CCc3c(c4ccccc4n3Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2)CC1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288430 | 100667 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 547 | 13 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL295281 | 100667 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 547 | 13 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44288735 | 161628 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 8.5 | CC(C)(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL416249 | 161628 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 8.5 | CC(C)(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| 9959856 | 167896 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 575 | 12 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43509 | 167896 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 575 | 12 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44319827 | 204649 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 635 | 11 | 1 | 4 | 10.5 | O=C(O)CC1(CS[C@H](CCc2ccccc2C(F)(F)F)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL87528 | 204649 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 635 | 11 | 1 | 4 | 10.5 | O=C(O)CC1(CS[C@H](CCc2ccccc2C(F)(F)F)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 45272532 | 194167 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 505 | 7 | 1 | 4 | 6.4 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL558443 | 194167 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 505 | 7 | 1 | 4 | 6.4 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 45268232 | 194496 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 494 | 8 | 1 | 3 | 7.8 | Cc1c(CCCC(=O)O)c2ccccc2n1Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL561321 | 194496 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 494 | 8 | 1 | 3 | 7.8 | Cc1c(CCCC(=O)O)c2ccccc2n1Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44269922 | 98105 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 592 | 13 | 2 | 6 | 6.6 | CC(CSC(CCc1ccccc1C(=O)N(C)CO)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL276584 | 98105 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 592 | 13 | 2 | 6 | 6.6 | CC(CSC(CCc1ccccc1C(=O)N(C)CO)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44361485 | 35065 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 557 | 12 | 1 | 4 | 8.8 | CCC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL143639 | 35065 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 557 | 12 | 1 | 4 | 8.8 | CCC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| 44361525 | 118910 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 573 | 12 | 1 | 5 | 8.4 | CCOC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL344756 | 118910 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 573 | 12 | 1 | 5 | 8.4 | CCOC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| 6193 | 3921 | 33 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00265-U | ||
| 6509849 | 3921 | 33 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL280481 | 3921 | 33 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00265-U | ||
| 10346 | 2522 | 40 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 5281888 | 2522 | 40 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15177 | 2522 | 40 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 137660132 | 158972 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 429 | 8 | 1 | 7 | 4.2 | CCCCCc1ccc(/C=C/C(=O)Nc2cccc3c(=O)cc(-n4cnnn4)oc23)cc1 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL4102154 | 158972 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 429 | 8 | 1 | 7 | 4.2 | CCCCCc1ccc(/C=C/C(=O)Nc2cccc3c(=O)cc(-n4cnnn4)oc23)cc1 | 10.1021/acs.jmedchem.6b01287 | ||
| 45269187 | 194377 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 535 | 8 | 1 | 4 | 7.3 | O=C(O)CCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL560385 | 194377 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 535 | 8 | 1 | 4 | 7.3 | O=C(O)CCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 10391331 | 169513 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 2 | 5 | 6.6 | O=C(O)CCSC(SCCC(=O)O)c1cccc(C2CC2c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL444331 | 169513 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 2 | 5 | 6.6 | O=C(O)CCSC(SCCC(=O)O)c1cccc(C2CC2c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 10399041 | 116505 | 2 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 232 | 2 | 0 | 2 | 3.8 | C(=C/c1ccc2ccccc2n1)\c1ccncc1 | 10.1021/jm00099a011 | ||
| CHEMBL338876 | 116505 | 2 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 232 | 2 | 0 | 2 | 3.8 | C(=C/c1ccc2ccccc2n1)\c1ccncc1 | 10.1021/jm00099a011 | ||
| 2812 | 4711 | 96 | None | -58 | 34 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
| CHEMBL104 | 4711 | 96 | None | -58 | 34 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
| 19930521 | 46596 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 516 | 12 | 1 | 5 | 6.1 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15405 | 46596 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 516 | 12 | 1 | 5 | 6.1 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 45270815 | 193532 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 499 | 7 | 1 | 5 | 6.4 | CC(C)(C)c1csc(/C=C/c2cccc(Cn3c4c(c5ccccc53)CN(CCC(=O)O)CC4)c2)n1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL550654 | 193532 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 499 | 7 | 1 | 5 | 6.4 | CC(C)(C)c1csc(/C=C/c2cccc(Cn3c4c(c5ccccc53)CN(CCC(=O)O)CC4)c2)n1 | 10.1016/j.bmcl.2009.05.094 | ||
| 9871637 | 161423 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 507 | 12 | 2 | 5 | 7.2 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nccs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL415903 | 161423 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 507 | 12 | 2 | 5 | 7.2 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nccs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 22848869 | 14430 | 0 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204695 | 14430 | 0 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15306 | 14430 | 0 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 45268320 | 194690 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 533 | 7 | 1 | 4 | 7.1 | O=C(O)/C=C/CN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL562524 | 194690 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 533 | 7 | 1 | 4 | 7.1 | O=C(O)/C=C/CN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 2237 | 3113 | 73 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | ||
| 3634 | 3113 | 73 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | ||
| 4887 | 3113 | 73 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL21333 | 3113 | 73 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | ||
| DB01411 | 3113 | 73 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | ||
| 44361688 | 14716 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 605 | 12 | 1 | 4 | 9.4 | C[C@H](CS[C@@H](CCc1ccccc1C(=O)c1ccccc1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL120779 | 14716 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 605 | 12 | 1 | 4 | 9.4 | C[C@H](CS[C@@H](CCc1ccccc1C(=O)c1ccccc1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| 45271634 | 193416 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 480 | 8 | 1 | 3 | 7.5 | O=C(O)CCCc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL549700 | 193416 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 480 | 8 | 1 | 3 | 7.5 | O=C(O)CCCc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | ||
| 2237 | 3113 | 73 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| 3634 | 3113 | 73 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| 4887 | 3113 | 73 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL21333 | 3113 | 73 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| DB01411 | 3113 | 73 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| 45272547 | 193973 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3ccc(F)cc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL556420 | 193973 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3ccc(F)cc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288196 | 168364 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 547 | 12 | 2 | 5 | 7.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCC3)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43874 | 168364 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 547 | 12 | 2 | 5 | 7.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCC3)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44319977 | 204042 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 645 | 11 | 1 | 4 | 10.2 | O=C(O)CC1(CS[C@H](CCc2ccc(Br)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL82790 | 204042 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 645 | 11 | 1 | 4 | 10.2 | O=C(O)CC1(CS[C@H](CCc2ccc(Br)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 45273394 | 194753 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 516 | 7 | 1 | 3 | 8.2 | O=C(O)CCc1ccc2c(c1)c1ccccc1n2Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL562930 | 194753 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 516 | 7 | 1 | 3 | 8.2 | O=C(O)CCc1ccc2c(c1)c1ccccc1n2Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | ||
| 45267392 | 195022 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 506 | 6 | 1 | 3 | 7.6 | O=C(O)CC1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL564798 | 195022 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 506 | 6 | 1 | 3 | 7.6 | O=C(O)CC1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 57109 | 83070 | 18 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| CHEMBL22016 | 83070 | 18 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| 105007 | 96653 | 24 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm960088k | ||
| CHEMBL267475 | 96653 | 24 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm960088k | ||
| CHEMBL267976 | 96653 | 24 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm960088k | ||
| 57109 | 83070 | 18 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL22016 | 83070 | 18 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 45271619 | 193703 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 525 | 8 | 1 | 5 | 6.3 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(OCc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL551923 | 193703 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 525 | 8 | 1 | 5 | 6.3 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(OCc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288373 | 156036 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 629 | 15 | 2 | 6 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(CSc3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL40686 | 156036 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 629 | 15 | 2 | 6 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(CSc3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 2855 | 4069 | 100 | None | -1 | 6 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | ||
| 3322 | 4069 | 100 | None | -1 | 6 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | ||
| 5717 | 4069 | 100 | None | -1 | 6 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | ||
| CHEMBL603 | 4069 | 100 | None | -1 | 6 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | ||
| DB00549 | 4069 | 100 | None | -1 | 6 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | ||
| 10073436 | 14414 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 11 | 3 | 6 | 4.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(NC(=O)c2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL1204572 | 14414 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 11 | 3 | 6 | 4.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(NC(=O)c2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL338166 | 14414 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 11 | 3 | 6 | 4.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(NC(=O)c2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | ||
| 44288320 | 164968 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 587 | 13 | 2 | 6 | 8.4 | COc1ccc2nc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)sc2c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL42410 | 164968 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 587 | 13 | 2 | 6 | 8.4 | COc1ccc2nc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)sc2c1 | 10.1016/0960-894X(95)00265-U | ||
| 44360844 | 119290 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 583 | 12 | 2 | 4 | 8.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)C(C)(C)CCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL348229 | 119290 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 583 | 12 | 2 | 4 | 8.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)C(C)(C)CCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 22848881 | 14596 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206471 | 14596 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL277533 | 14596 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44288249 | 158714 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 8.6 | Cc1sc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL40992 | 158714 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 8.6 | Cc1sc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/0960-894X(95)00265-U | ||
| 44361742 | 34192 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 543 | 11 | 1 | 4 | 8.4 | CC(=O)c1cccc(CC[C@H](SC[C@@H](C)C(=O)O)c2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL142805 | 34192 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 543 | 11 | 1 | 4 | 8.4 | CC(=O)c1cccc(CC[C@H](SC[C@@H](C)C(=O)O)c2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| 45273410 | 194954 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 7 | 1 | 5 | 7.6 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL564275 | 194954 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 7 | 1 | 5 | 7.6 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 14329740 | 193392 | 1 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CC[C@@H](C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL54955 | 193392 | 1 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CC[C@@H](C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 14329749 | 193013 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 512 | 14 | 2 | 7 | 5.5 | CCCc1c(OCCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL53252 | 193013 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 512 | 14 | 2 | 7 | 5.5 | CCCc1c(OCCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 10413257 | 16326 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 12 | 2 | 5 | 6.1 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL123623 | 16326 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 12 | 2 | 5 | 6.1 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 9888588 | 62197 | 3 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 424 | 9 | 2 | 4 | 5.2 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccc(F)cc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | ||
| CHEMBL178221 | 62197 | 3 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 424 | 9 | 2 | 4 | 5.2 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccc(F)cc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | ||
| 44288180 | 144054 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(Cl)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL39077 | 144054 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(Cl)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44269986 | 14433 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 547 | 12 | 1 | 4 | 8.7 | CC(CSC(CCc1ccccc1C(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204698 | 14433 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 547 | 12 | 1 | 4 | 8.7 | CC(CSC(CCc1ccccc1C(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15419 | 14433 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 547 | 12 | 1 | 4 | 8.7 | CC(CSC(CCc1ccccc1C(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44319716 | 105512 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 733 | 12 | 2 | 5 | 10.7 | O=C(O)CC1(CS[C@H](CCc2ccccc2C(O)(C(F)(F)F)C(F)(F)F)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL313177 | 105512 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 733 | 12 | 2 | 5 | 10.7 | O=C(O)CC1(CS[C@H](CCc2ccccc2C(O)(C(F)(F)F)C(F)(F)F)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 44270014 | 14434 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 491 | 11 | 1 | 4 | 7.3 | O=C(O)CCSC(CCc1ccccc1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204699 | 14434 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 491 | 11 | 1 | 4 | 7.3 | O=C(O)CCSC(CCc1ccccc1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15481 | 14434 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 491 | 11 | 1 | 4 | 7.3 | O=C(O)CCSC(CCc1ccccc1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44269880 | 14708 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1207684 | 14708 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL429975 | 14708 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44288614 | 96031 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 601 | 13 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL262391 | 96031 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 601 | 13 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44288480 | 165412 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL42520 | 165412 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44350320 | 16493 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 11 | 1 | 5 | 6.6 | CN(C)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL124259 | 16493 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 11 | 1 | 5 | 6.6 | CN(C)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 5357469 | 18368 | 25 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 231 | 2 | 0 | 1 | 4.4 | C(=C/c1ccc2ccccc2n1)\c1ccccc1 | 10.1021/jm00099a011 | ||
| CHEMBL127579 | 18368 | 25 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 231 | 2 | 0 | 1 | 4.4 | C(=C/c1ccc2ccccc2n1)\c1ccccc1 | 10.1021/jm00099a011 | ||
| 5376707 | 18613 | 16 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 232 | 2 | 0 | 2 | 3.8 | C(=C/c1ccc2ccccc2n1)\c1cccnc1 | 10.1021/jm00099a011 | ||
| CHEMBL127816 | 18613 | 16 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 232 | 2 | 0 | 2 | 3.8 | C(=C/c1ccc2ccccc2n1)\c1cccnc1 | 10.1021/jm00099a011 | ||
| 14329737 | 194081 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 470 | 11 | 2 | 7 | 4.4 | CCCc1c(OCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL55750 | 194081 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 470 | 11 | 2 | 7 | 4.4 | CCCc1c(OCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 45267388 | 194790 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 509 | 9 | 1 | 4 | 7.0 | CN(CCC(=O)O)Cc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL563165 | 194790 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 509 | 9 | 1 | 4 | 7.0 | CN(CCC(=O)O)Cc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | ||
| 22416877 | 60104 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 440 | 9 | 2 | 4 | 5.7 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | ||
| CHEMBL175119 | 60104 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 440 | 9 | 2 | 4 | 5.7 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | ||
| 5280878 | 99809 | 24 | None | 2 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmc.2010.07.034 | ||
| CHEMBL288943 | 99809 | 24 | None | 2 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmc.2010.07.034 | ||
| 44361511 | 33988 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 559 | 11 | 1 | 5 | 8.0 | COC(=O)c1cccc(CC[C@H](SC[C@@H](C)C(=O)O)c2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL142627 | 33988 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 559 | 11 | 1 | 5 | 8.0 | COC(=O)c1cccc(CC[C@H](SC[C@@H](C)C(=O)O)c2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| 22848881 | 14596 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206471 | 14596 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL277533 | 14596 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 45270818 | 193556 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 551 | 8 | 1 | 5 | 6.9 | COc1ccc2c(c1)c1c(n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)CCN(CCC(=O)O)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL550859 | 193556 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 551 | 8 | 1 | 5 | 6.9 | COc1ccc2c(c1)c1c(n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)CCN(CCC(=O)O)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288324 | 161213 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(C(F)(F)F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL41395 | 161213 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(C(F)(F)F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44288180 | 144054 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(Cl)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL39077 | 144054 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(Cl)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 14541261 | 189573 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 532 | 11 | 2 | 7 | 5.7 | CCCc1c(OCc2cccc(COc3cc4c(cc3C(C)=O)CCC(C(=O)O)O4)c2)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL51739 | 189573 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 532 | 11 | 2 | 7 | 5.7 | CCCc1c(OCc2cccc(COc3cc4c(cc3C(C)=O)CCC(C(=O)O)O4)c2)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 14541297 | 193027 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 496 | 13 | 2 | 6 | 5.6 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)C3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL53347 | 193027 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 496 | 13 | 2 | 6 | 5.6 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)C3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 10392358 | 47609 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 6.6 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(SCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15491 | 47609 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 6.6 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(SCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44288319 | 168305 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 617 | 13 | 2 | 5 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(Cl)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43821 | 168305 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 617 | 13 | 2 | 5 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(Cl)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 6193 | 3921 | 33 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | ||
| 6509849 | 3921 | 33 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | ||
| CHEMBL280481 | 3921 | 33 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | ||
| 15290701 | 204445 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 557 | 12 | 2 | 5 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sccc3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL86264 | 204445 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 557 | 12 | 2 | 5 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sccc3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 44269987 | 47542 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 528 | 13 | 1 | 5 | 6.6 | CC(CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15485 | 47542 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 528 | 13 | 1 | 5 | 6.6 | CC(CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 44319774 | 204279 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 635 | 11 | 1 | 4 | 10.5 | O=C(O)CC1(CS[C@H](CCc2ccc(C(F)(F)F)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL84841 | 204279 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 635 | 11 | 1 | 4 | 10.5 | O=C(O)CC1(CS[C@H](CCc2ccc(C(F)(F)F)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 44350182 | 16408 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 12 | 1 | 6 | 5.9 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(SCc2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL123958 | 16408 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 12 | 1 | 6 | 5.9 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(SCc2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | ||
| 9822618 | 129212 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 406 | 9 | 2 | 4 | 5.0 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccccc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | ||
| CHEMBL367424 | 129212 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 406 | 9 | 2 | 4 | 5.0 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccccc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | ||
| 45271629 | 193879 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 523 | 10 | 1 | 4 | 7.0 | CN(CCC(=O)O)CCc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL554691 | 193879 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 523 | 10 | 1 | 4 | 7.0 | CN(CCC(=O)O)CCc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288613 | 157295 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 613 | 14 | 2 | 6 | 8.9 | COc1ccc(-c2csc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)n2)cc1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL40836 | 157295 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 613 | 14 | 2 | 6 | 8.9 | COc1ccc(-c2csc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)n2)cc1 | 10.1016/0960-894X(95)00265-U | ||
| 44288319 | 168305 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 617 | 13 | 2 | 5 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(Cl)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43821 | 168305 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 617 | 13 | 2 | 5 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(Cl)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 10346 | 2522 | 40 | None | - | 1 | Guinea pig | 9.0 | pKd | = | 9 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00166a017 | ||
| 5281888 | 2522 | 40 | None | - | 1 | Guinea pig | 9.0 | pKd | = | 9 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00166a017 | ||
| CHEMBL15177 | 2522 | 40 | None | - | 1 | Guinea pig | 9.0 | pKd | = | 9 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00166a017 | ||
| 10839186 | 119202 | 0 | None | - | 1 | Guinea pig | 7.0 | pKd | = | 7 | Binding | ChEMBL | 502 | 5 | 1 | 6 | 5.4 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ncc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL34740 | 119202 | 0 | None | - | 1 | Guinea pig | 7.0 | pKd | = | 7 | Binding | ChEMBL | 502 | 5 | 1 | 6 | 5.4 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ncc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 9890153 | 161968 | 0 | None | - | 1 | Guinea pig | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 453 | 4 | 1 | 4 | 6.5 | O=C(O)c1cc(Cl)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL416769 | 161968 | 0 | None | - | 1 | Guinea pig | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 453 | 4 | 1 | 4 | 6.5 | O=C(O)c1cc(Cl)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10764782 | 162189 | 0 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 424 | 5 | 1 | 6 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ncc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| CHEMBL417135 | 162189 | 0 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 424 | 5 | 1 | 6 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ncc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| 15485487 | 113161 | 0 | None | - | 1 | Guinea pig | 5.0 | pKd | = | 5.0 | Binding | ChEMBL | 477 | 4 | 1 | 6 | 6.0 | O=c1cc(-c2cccc(/C=C/c3ccc4ccccc4n3)c2)oc2c(-c3nn[nH]n3)cc(Cl)cc12 | 10.1021/jm970179x | ||
| CHEMBL33228 | 113161 | 0 | None | - | 1 | Guinea pig | 5.0 | pKd | = | 5.0 | Binding | ChEMBL | 477 | 4 | 1 | 6 | 6.0 | O=c1cc(-c2cccc(/C=C/c3ccc4ccccc4n3)c2)oc2c(-c3nn[nH]n3)cc(Cl)cc12 | 10.1021/jm970179x | ||
| 105007 | 96653 | 24 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00013a023 | ||
| CHEMBL267475 | 96653 | 24 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00013a023 | ||
| CHEMBL267976 | 96653 | 24 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00013a023 | ||
| 10649085 | 118238 | 0 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 500 | 5 | 1 | 4 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5c4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL34177 | 118238 | 0 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 500 | 5 | 1 | 4 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5c4)c3)oc12 | 10.1021/jm970179x | ||
| 10792471 | 116207 | 0 | None | - | 1 | Guinea pig | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 535 | 5 | 1 | 5 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccc(Cl)cc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL33729 | 116207 | 0 | None | - | 1 | Guinea pig | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 535 | 5 | 1 | 5 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccc(Cl)cc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10717827 | 99251 | 0 | None | - | 1 | Guinea pig | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 437 | 4 | 1 | 4 | 6.0 | O=C(O)c1cc(F)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL284730 | 99251 | 0 | None | - | 1 | Guinea pig | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 437 | 4 | 1 | 4 | 6.0 | O=C(O)c1cc(F)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10765224 | 119305 | 0 | None | - | 1 | Guinea pig | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 433 | 4 | 1 | 4 | 6.2 | Cc1cc(C(=O)O)c2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | ||
| CHEMBL34835 | 119305 | 0 | None | - | 1 | Guinea pig | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 433 | 4 | 1 | 4 | 6.2 | Cc1cc(C(=O)O)c2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | ||
| 10526098 | 99238 | 1 | None | - | 1 | Guinea pig | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL284624 | 99238 | 1 | None | - | 1 | Guinea pig | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10767627 | 108619 | 0 | None | - | 1 | Guinea pig | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 497 | 4 | 1 | 4 | 6.6 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL32136 | 108619 | 0 | None | - | 1 | Guinea pig | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 497 | 4 | 1 | 4 | 6.6 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10574284 | 116472 | 0 | None | - | 1 | Guinea pig | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL33871 | 116472 | 0 | None | - | 1 | Guinea pig | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10764530 | 111862 | 0 | None | - | 1 | Guinea pig | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc2c1 | 10.1021/jm970179x | ||
| CHEMBL32944 | 111862 | 0 | None | - | 1 | Guinea pig | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc2c1 | 10.1021/jm970179x | ||
| 10787157 | 113609 | 0 | None | - | 1 | Guinea pig | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 400 | 3 | 0 | 4 | 6.1 | N#Cc1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | ||
| CHEMBL33276 | 113609 | 0 | None | - | 1 | Guinea pig | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 400 | 3 | 0 | 4 | 6.1 | N#Cc1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | ||
| 10577476 | 113941 | 0 | None | - | 1 | Guinea pig | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 504 | 5 | 1 | 6 | 5.4 | Cn1c(COc2cccc(-c3cc(=O)c4cc(Br)cc(C(=O)O)c4o3)c2)nc2ccccc21 | 10.1021/jm970179x | ||
| CHEMBL33331 | 113941 | 0 | None | - | 1 | Guinea pig | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 504 | 5 | 1 | 6 | 5.4 | Cn1c(COc2cccc(-c3cc(=O)c4cc(Br)cc(C(=O)O)c4o3)c2)nc2ccccc21 | 10.1021/jm970179x | ||
| 44461723 | 204239 | 0 | None | -398 | 2 | Guinea pig | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 519 | 8 | 0 | 8 | 7.0 | O=c1cc(C2N=NN=N2)oc2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc12 | 10.1021/jm00013a023 | ||
| CHEMBL84407 | 204239 | 0 | None | -398 | 2 | Guinea pig | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 519 | 8 | 0 | 8 | 7.0 | O=c1cc(C2N=NN=N2)oc2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc12 | 10.1021/jm00013a023 | ||
| 10502162 | 110983 | 0 | None | - | 1 | Guinea pig | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3ccc(/C=C/c4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| CHEMBL32764 | 110983 | 0 | None | - | 1 | Guinea pig | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3ccc(/C=C/c4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| 115219 | 1947 | 10 | None | -489 | 3 | Guinea pig | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/S0960-894X(97)00219-9 | ||
| 3358 | 1947 | 10 | None | -489 | 3 | Guinea pig | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/S0960-894X(97)00219-9 | ||
| 3414 | 1947 | 10 | None | -489 | 3 | Guinea pig | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/S0960-894X(97)00219-9 | ||
| CHEMBL22033 | 1947 | 10 | None | -489 | 3 | Guinea pig | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/S0960-894X(97)00219-9 | ||
| 15485486 | 115938 | 0 | None | - | 1 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 443 | 4 | 1 | 6 | 5.4 | O=c1cc(-c2cccc(/C=C/c3ccc4ccccc4n3)c2)oc2ccc(-c3nn[nH]n3)cc12 | 10.1021/jm970179x | ||
| CHEMBL33607 | 115938 | 0 | None | - | 1 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 443 | 4 | 1 | 6 | 5.4 | O=c1cc(-c2cccc(/C=C/c3ccc4ccccc4n3)c2)oc2ccc(-c3nn[nH]n3)cc12 | 10.1021/jm970179x | ||
| 10553494 | 108634 | 0 | None | - | 1 | Guinea pig | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL32138 | 108634 | 0 | None | - | 1 | Guinea pig | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10651746 | 99429 | 0 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 640 | 7 | 1 | 7 | 6.5 | O=C(NS(=O)(=O)c1ccccc1)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| CHEMBL285994 | 99429 | 0 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 640 | 7 | 1 | 7 | 6.5 | O=C(NS(=O)(=O)c1ccccc1)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| 10598159 | 113939 | 0 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | ||
| CHEMBL33329 | 113939 | 0 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | ||
| 10435880 | 203649 | 0 | None | -707 | 2 | Guinea pig | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 495 | 8 | 1 | 5 | 5.9 | O=C(O)c1cc(=O)c2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc2o1 | 10.1021/jm00013a023 | ||
| CHEMBL79732 | 203649 | 0 | None | -707 | 2 | Guinea pig | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 495 | 8 | 1 | 5 | 5.9 | O=C(O)c1cc(=O)c2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc2o1 | 10.1021/jm00013a023 | ||
| 10649109 | 118946 | 0 | None | - | 1 | Guinea pig | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| CHEMBL34507 | 118946 | 0 | None | - | 1 | Guinea pig | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| 11796528 | 113654 | 0 | None | - | 1 | Guinea pig | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| CHEMBL33294 | 113654 | 0 | None | - | 1 | Guinea pig | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| 10619270 | 99550 | 0 | None | - | 1 | Guinea pig | 4.3 | pKd | = | 4.3 | Binding | ChEMBL | 372 | 5 | 1 | 4 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccccc4)cc3)oc12 | 10.1021/jm970179x | ||
| CHEMBL286797 | 99550 | 0 | None | - | 1 | Guinea pig | 4.3 | pKd | = | 4.3 | Binding | ChEMBL | 372 | 5 | 1 | 4 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccccc4)cc3)oc12 | 10.1021/jm970179x | ||
| 10553667 | 99653 | 0 | None | - | 1 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 507 | 5 | 1 | 6 | 6.1 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4nc5ccccc5s4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL287559 | 99653 | 0 | None | - | 1 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 507 | 5 | 1 | 6 | 6.1 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4nc5ccccc5s4)c3)oc12 | 10.1021/jm970179x | ||
| 15675874 | 179062 | 0 | None | - | 1 | Guinea pig | 10.0 | pKi | = | 10 | Binding | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| CHEMBL47430 | 179062 | 0 | None | - | 1 | Guinea pig | 10.0 | pKi | = | 10 | Binding | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| 15675885 | 177926 | 0 | None | - | 1 | Guinea pig | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2cc(COc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| CHEMBL46663 | 177926 | 0 | None | - | 1 | Guinea pig | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2cc(COc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| 10346 | 2522 | 40 | None | - | 1 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00108a001 | ||
| 5281888 | 2522 | 40 | None | - | 1 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00108a001 | ||
| CHEMBL15177 | 2522 | 40 | None | - | 1 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00108a001 | ||
| 5280878 | 99809 | 24 | None | 2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmcl.2013.01.025 | ||
| CHEMBL288943 | 99809 | 24 | None | 2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmcl.2013.01.025 | ||
| 115219 | 1947 | 10 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00109a025 | ||
| 3358 | 1947 | 10 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00109a025 | ||
| 3414 | 1947 | 10 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00109a025 | ||
| CHEMBL22033 | 1947 | 10 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00109a025 | ||
| 15675873 | 171599 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 477 | 7 | 1 | 7 | 4.8 | O=C1CC(c2nnn[nH]2)Oc2cc(CCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| CHEMBL44734 | 171599 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 477 | 7 | 1 | 7 | 4.8 | O=C1CC(c2nnn[nH]2)Oc2cc(CCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| 2855 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | ||
| 3322 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | ||
| 5717 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | ||
| CHEMBL603 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | ||
| DB00549 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | ||
| 2855 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | ||
| 3322 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | ||
| 5717 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | ||
| CHEMBL603 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | ||
| DB00549 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | ||
| 115219 | 1947 | 10 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00108a001 | ||
| 3358 | 1947 | 10 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00108a001 | ||
| 3414 | 1947 | 10 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00108a001 | ||
| CHEMBL22033 | 1947 | 10 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00108a001 | ||
| 2855 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| 3322 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| 5717 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL603 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| DB00549 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| 2855 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | ||
| 3322 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | ||
| 5717 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | ||
| CHEMBL603 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | ||
| DB00549 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | ||
| 14626819 | 188081 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 559 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL50370 | 188081 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 559 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 10461224 | 116590 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 601 | 11 | 2 | 6 | 6.0 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc21 | 10.1021/jm00055a011 | ||
| CHEMBL339277 | 116590 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 601 | 11 | 2 | 6 | 6.0 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc21 | 10.1021/jm00055a011 | ||
| 2855 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | ||
| 3322 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | ||
| 5717 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | ||
| CHEMBL603 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | ||
| DB00549 | 4069 | 100 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | ||
| 10349048 | 96499 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 629 | 11 | 2 | 6 | 6.0 | CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)CC(F)(F)F)ccc21 | 10.1021/jm00035a008 | ||
| CHEMBL26617 | 96499 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 629 | 11 | 2 | 6 | 6.0 | CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)CC(F)(F)F)ccc21 | 10.1021/jm00035a008 | ||
| 10077296 | 19961 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 599 | 11 | 2 | 6 | 5.8 | C=CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc21 | 10.1021/jm00055a011 | ||
| CHEMBL130463 | 19961 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 599 | 11 | 2 | 6 | 5.8 | C=CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc21 | 10.1021/jm00055a011 | ||
| 9895247 | 206072 | 1 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 616 | 8 | 2 | 8 | 5.7 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@@H]1O | 10.1016/s0960-894x(99)00461-8 | ||
| CHEMBL96224 | 206072 | 1 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 616 | 8 | 2 | 8 | 5.7 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@@H]1O | 10.1016/s0960-894x(99)00461-8 | ||
| 204056 | 168833 | 24 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC[C@H](C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL442263 | 168833 | 24 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC[C@H](C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 10054552 | 93009 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.8 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1cc(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| CHEMBL24596 | 93009 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.8 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1cc(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| 1836 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | ||
| 3340 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | ||
| 5281040 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | ||
| CHEMBL787 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | ||
| DB00471 | 2554 | 56 | None | 1 | 15 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | ||
| 14626858 | 190590 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL51891 | 190590 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 14626821 | 192754 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 588 | 10 | 3 | 6 | 5.8 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(NC(=O)NC3CCCC3)ccc21 | 10.1021/jm00168a037 | ||
| CHEMBL52492 | 192754 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 588 | 10 | 3 | 6 | 5.8 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(NC(=O)NC3CCCC3)ccc21 | 10.1021/jm00168a037 | ||
| 10371436 | 116578 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 603 | 12 | 2 | 6 | 6.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C(C)C | 10.1021/jm00055a011 | ||
| CHEMBL339242 | 116578 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 603 | 12 | 2 | 6 | 6.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C(C)C | 10.1021/jm00055a011 | ||
| 14626858 | 190590 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL51891 | 190590 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00055a011 | ||
| 9986282 | 93148 | 6 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL24652 | 93148 | 6 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 10258533 | 95378 | 0 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 635 | 10 | 2 | 6 | 5.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL25885 | 95378 | 0 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 635 | 10 | 2 | 6 | 5.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 5280878 | 99809 | 24 | None | 2 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/np50094a001 | ||
| CHEMBL288943 | 99809 | 24 | None | 2 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/np50094a001 | ||
| 9830317 | 206068 | 7 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 608 | 8 | 2 | 7 | 6.0 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc2[C@@H]1O | 10.1016/s0960-894x(99)00461-8 | ||
| CHEMBL96206 | 206068 | 7 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 608 | 8 | 2 | 7 | 6.0 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc2[C@@H]1O | 10.1016/s0960-894x(99)00461-8 | ||
| 10483776 | 114321 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc21 | 10.1021/jm00055a011 | ||
| CHEMBL334122 | 114321 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc21 | 10.1021/jm00055a011 | ||
| 14626814 | 183757 | 0 | None | -10 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 561 | 8 | 2 | 7 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL48435 | 183757 | 0 | None | -10 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 561 | 8 | 2 | 7 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.6b01287 | ||
| 14626820 | 101513 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 560 | 8 | 3 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL301498 | 101513 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 560 | 8 | 3 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 2237 | 3113 | 73 | None | 4 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | ||
| 3634 | 3113 | 73 | None | 4 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | ||
| 4887 | 3113 | 73 | None | 4 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | ||
| CHEMBL21333 | 3113 | 73 | None | 4 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | ||
| DB01411 | 3113 | 73 | None | 4 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | ||
| 2855 | 4069 | 100 | None | 1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| 3322 | 4069 | 100 | None | 1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| 5717 | 4069 | 100 | None | 1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| DB00549 | 4069 | 100 | None | 1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| 10394412 | 23803 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 643 | 13 | 2 | 6 | 7.0 | CCC(CC)CNC(=O)c1ccc2c(CC3CCCC3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL133790 | 23803 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 643 | 13 | 2 | 6 | 7.0 | CCC(CC)CNC(=O)c1ccc2c(CC3CCCC3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 10326077 | 20936 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CC | 10.1021/jm00055a011 | ||
| CHEMBL131247 | 20936 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CC | 10.1021/jm00055a011 | ||
| 5280878 | 99809 | 24 | None | -2 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL288943 | 99809 | 24 | None | -2 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| 14626857 | 101428 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 559 | 9 | 3 | 5 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1c[nH]c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL300846 | 101428 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 559 | 9 | 3 | 5 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1c[nH]c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 9891157 | 21859 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 476 | 8 | 2 | 4 | 5.6 | O=C(O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL132162 | 21859 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 476 | 8 | 2 | 4 | 5.6 | O=C(O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 15675887 | 180971 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 492 | 6 | 2 | 8 | 4.3 | O=C(Nc1cccc2c1OC(c1nnn[nH]1)CC2=O)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00109a025 | ||
| CHEMBL47662 | 180971 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 492 | 6 | 2 | 8 | 4.3 | O=C(Nc1cccc2c1OC(c1nnn[nH]1)CC2=O)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00109a025 | ||
| 14842376 | 99300 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 490 | 6 | 2 | 8 | 4.4 | O=C(Nc1cccc2c(=O)cc(-c3nn[nH]n3)oc12)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm970180w | ||
| CHEMBL285070 | 99300 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 490 | 6 | 2 | 8 | 4.4 | O=C(Nc1cccc2c(=O)cc(-c3nn[nH]n3)oc12)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm970180w | ||
| 1836 | 2554 | 56 | None | -1 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| 3340 | 2554 | 56 | None | -1 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| 5281040 | 2554 | 56 | None | -1 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| CHEMBL787 | 2554 | 56 | None | -1 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| DB00471 | 2554 | 56 | None | -1 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| 9935613 | 100769 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 9 | 1 | 6 | 6.0 | CC1(CCC(=O)O)CC(=O)c2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1 | 10.1021/jm00109a025 | ||
| CHEMBL296097 | 100769 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 9 | 1 | 6 | 6.0 | CC1(CCC(=O)O)CC(=O)c2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1 | 10.1021/jm00109a025 | ||
| 10417026 | 92855 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 669 | 10 | 2 | 6 | 6.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C(F)(F)F)C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL24505 | 92855 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 669 | 10 | 2 | 6 | 6.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C(F)(F)F)C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 10348645 | 20473 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL130872 | 20473 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| 9986751 | 115770 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 651 | 13 | 2 | 6 | 6.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2Cc1ccccc1 | 10.1021/jm00055a011 | ||
| CHEMBL335889 | 115770 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 651 | 13 | 2 | 6 | 6.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2Cc1ccccc1 | 10.1021/jm00055a011 | ||
| 15675876 | 176588 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc21 | 10.1021/jm00109a025 | ||
| CHEMBL46343 | 176588 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc21 | 10.1021/jm00109a025 | ||
| 10009390 | 95762 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 645 | 9 | 2 | 6 | 5.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CC(F)(F)C(F)(F)C3)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL26080 | 95762 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 645 | 9 | 2 | 6 | 5.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CC(F)(F)C(F)(F)C3)cc12 | 10.1021/jm00035a008 | ||
| 14626863 | 167348 | 1 | None | -1 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 574 | 8 | 3 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL431348 | 167348 | 1 | None | -1 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 574 | 8 | 3 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 9986283 | 93374 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC[C@@H](C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL24758 | 93374 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC[C@@H](C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 44352406 | 21314 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131611 | 21314 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 10394407 | 95250 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 643 | 12 | 2 | 6 | 6.4 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)CC(F)(F)F)ccc21 | 10.1021/jm00035a008 | ||
| CHEMBL25819 | 95250 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 643 | 12 | 2 | 6 | 6.4 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)CC(F)(F)F)ccc21 | 10.1021/jm00035a008 | ||
| 9985579 | 98679 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL281066 | 98679 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 10348137 | 19930 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.5 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)C)ccc21 | 10.1021/jm00055a011 | ||
| CHEMBL130428 | 19930 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.5 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)C)ccc21 | 10.1021/jm00055a011 | ||
| 44285405 | 153856 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](Sc1cccc(C(=O)O)c1)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL39876 | 153856 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](Sc1cccc(C(=O)O)c1)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| 44285360 | 167724 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 410 | 17 | 3 | 4 | 5.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL434013 | 167724 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 410 | 17 | 3 | 4 | 5.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| 44272172 | 66469 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(OCc2cccc(OCc3ccc4ccccc4n3)c2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18600 | 66469 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(OCc2cccc(OCc3ccc4ccccc4n3)c2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 9888538 | 66624 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18671 | 66624 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | ||
| 10158419 | 162614 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2ccc(-c3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL418002 | 162614 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2ccc(-c3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 3334 | 3098 | 7 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | ||
| 60842 | 3098 | 7 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | ||
| CHEMBL22776 | 3098 | 7 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | ||
| 10461264 | 21225 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL131507 | 21225 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 10076815 | 203963 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1cc(C)c2ccc(C(=O)NCC3CCCC3)cc21 | 10.1021/jm00055a011 | ||
| CHEMBL82190 | 203963 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1cc(C)c2ccc(C(=O)NCC3CCCC3)cc21 | 10.1021/jm00055a011 | ||
| 15337931 | 204097 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 5.3 | Clc1ccc2ccc(COc3cccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL83267 | 204097 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 5.3 | Clc1ccc2ccc(COc3cccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| 10348087 | 20610 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 573 | 8 | 2 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC3CCCCC3)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL130985 | 20610 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 573 | 8 | 2 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC3CCCCC3)cc12 | 10.1021/jm00055a011 | ||
| 44353486 | 116238 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 601 | 9 | 1 | 6 | 5.9 | CCCC1CCN(C(=O)c2ccc3c(c2)c(Cc2ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc2OC)cn3C)CC1 | 10.1021/jm00055a011 | ||
| CHEMBL337473 | 116238 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 601 | 9 | 1 | 6 | 5.9 | CCCC1CCN(C(=O)c2ccc3c(c2)c(Cc2ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc2OC)cn3C)CC1 | 10.1021/jm00055a011 | ||
| 3381 | 582 | 24 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| 5311015 | 582 | 24 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL285954 | 582 | 24 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| 14406203 | 192932 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 322 | 5 | 1 | 4 | 3.2 | CN(O)C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00128a027 | ||
| CHEMBL52896 | 192932 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 322 | 5 | 1 | 4 | 3.2 | CN(O)C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00128a027 | ||
| 13770359 | 68952 | 2 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 235 | 3 | 0 | 2 | 3.8 | c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | ||
| CHEMBL19281 | 68952 | 2 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 235 | 3 | 0 | 2 | 3.8 | c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | ||
| 10047878 | 116960 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 422 | 9 | 2 | 4 | 4.9 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)O)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL339897 | 116960 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 422 | 9 | 2 | 4 | 4.9 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)O)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 10475982 | 161275 | 0 | None | 15 | 2 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| CHEMBL414462 | 161275 | 0 | None | 15 | 2 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| 129232 | 193290 | 28 | None | - | 1 | Guinea pig | 4.0 | pKi | = | 4 | Binding | ChEMBL | 271 | 5 | 1 | 3 | 2.7 | CN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1 | 10.1021/jm00128a027 | ||
| CHEMBL54453 | 193290 | 28 | None | - | 1 | Guinea pig | 4.0 | pKi | = | 4 | Binding | ChEMBL | 271 | 5 | 1 | 3 | 2.7 | CN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1 | 10.1021/jm00128a027 | ||
| 44352444 | 18764 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 503 | 8 | 2 | 7 | 4.3 | Cn1cc(CC(=O)NCc2ccc(-c3nn[nH]n3)cc2)c2cc(OCc3ccc4ccccc4n3)ccc21 | 10.1021/jm990387k | ||
| CHEMBL128676 | 18764 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 503 | 8 | 2 | 7 | 4.3 | Cn1cc(CC(=O)NCc2ccc(-c3nn[nH]n3)cc2)c2cc(OCc3ccc4ccccc4n3)ccc21 | 10.1021/jm990387k | ||
| 44352153 | 20968 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 450 | 8 | 2 | 6 | 4.1 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)Nc1ccc(Cc2nnn[nH]2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131266 | 20968 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 450 | 8 | 2 | 6 | 4.1 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)Nc1ccc(Cc2nnn[nH]2)cc1 | 10.1021/jm990387k | ||
| 14742716 | 206274 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 401 | 10 | 1 | 5 | 4.9 | CCCC(CCc1nnn[nH]1)Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00172a024 | ||
| CHEMBL97356 | 206274 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 401 | 10 | 1 | 5 | 4.9 | CCCC(CCc1nnn[nH]1)Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00172a024 | ||
| 14626843 | 101155 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 421 | 6 | 3 | 4 | 4.5 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL298939 | 101155 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 421 | 6 | 3 | 4 | 4.5 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 9948371 | 67030 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 303 | 4 | 1 | 5 | 3.0 | c1cc(OCc2ccc3ccccc3n2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18864 | 67030 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 303 | 4 | 1 | 5 | 3.0 | c1cc(OCc2ccc3ccccc3n2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a016 | ||
| 44352451 | 19942 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 6.4 | CC(C(=O)Nc1ccc(C(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL130442 | 19942 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 6.4 | CC(C(=O)Nc1ccc(C(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 9888539 | 64512 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18204 | 64512 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | ||
| 44352414 | 18727 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccccc1-c1nn[nH]n1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL128483 | 18727 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccccc1-c1nn[nH]n1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 10461218 | 99618 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL287302 | 99618 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 9985297 | 116161 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 561 | 11 | 2 | 6 | 5.3 | CCC(CC)CNC(=O)c1ccc2ccn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL337058 | 116161 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 561 | 11 | 2 | 6 | 5.3 | CCC(CC)CNC(=O)c1ccc2ccn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 14650365 | 64916 | 1 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 375 | 9 | 1 | 6 | 3.5 | c1ccc2nc(COCc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL18273 | 64916 | 1 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 375 | 9 | 1 | 6 | 3.5 | c1ccc2nc(COCc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 14650341 | 98199 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 337 | 8 | 1 | 4 | 4.1 | O=C(O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | ||
| CHEMBL277292 | 98199 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 337 | 8 | 1 | 4 | 4.1 | O=C(O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | ||
| 105007 | 96653 | 24 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00389a001 | ||
| CHEMBL267475 | 96653 | 24 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00389a001 | ||
| CHEMBL267976 | 96653 | 24 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00389a001 | ||
| 11758126 | 116088 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCCCC(CC)NC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL336607 | 116088 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCCCC(CC)NC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 44285543 | 146304 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 540 | 21 | 3 | 4 | 8.2 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL39250 | 146304 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 540 | 21 | 3 | 4 | 8.2 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 10203560 | 162279 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2cccc(OCc3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL417271 | 162279 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2cccc(OCc3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 15675883 | 175890 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2c(COc3ccc(OCc4ccc5ccccc5n4)cc3)cccc21 | 10.1021/jm00109a025 | ||
| CHEMBL45965 | 175890 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2c(COc3ccc(OCc4ccc5ccccc5n4)cc3)cccc21 | 10.1021/jm00109a025 | ||
| 23224640 | 19871 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 514 | 9 | 2 | 6 | 5.5 | O=C(NCCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| CHEMBL130384 | 19871 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 514 | 9 | 2 | 6 | 5.5 | O=C(NCCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| 44352282 | 117949 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 526 | 9 | 1 | 5 | 5.5 | CN(CCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| CHEMBL341172 | 117949 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 526 | 9 | 1 | 5 | 5.5 | CN(CCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| 9927762 | 65945 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 337 | 8 | 1 | 4 | 4.1 | O=C(O)CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18471 | 65945 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 337 | 8 | 1 | 4 | 4.1 | O=C(O)CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 10363485 | 58794 | 0 | None | 29 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| CHEMBL169743 | 58794 | 0 | None | 29 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| 44352421 | 21599 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 504 | 9 | 2 | 4 | 6.0 | CC(C(=O)NCc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL131934 | 21599 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 504 | 9 | 2 | 4 | 6.0 | CC(C(=O)NCc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 5352624 | 66903 | 40 | None | -4 | 5 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 340 | 4 | 1 | 2 | 5.4 | CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 | nan | ||
| CHEMBL18797 | 66903 | 40 | None | -4 | 5 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 340 | 4 | 1 | 2 | 5.4 | CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 | nan | ||
| 15675884 | 187359 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2c(COc3ccc(OCc4ccc5ccccc5n4)cc3)cccc21 | 10.1021/jm00109a025 | ||
| CHEMBL49696 | 187359 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2c(COc3ccc(OCc4ccc5ccccc5n4)cc3)cccc21 | 10.1021/jm00109a025 | ||
| 44352162 | 18434 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 629 | 10 | 2 | 6 | 6.4 | Cc1ccccc1S(=O)(=O)NC(=O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL127665 | 18434 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 629 | 10 | 2 | 6 | 6.4 | Cc1ccccc1S(=O)(=O)NC(=O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 44352411 | 167879 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 487 | 7 | 1 | 6 | 6.3 | O=C(O)c1ccc(Cc2noc(-c3ccc4ccc(OCc5ccc6ccccc6n5)cc4c3)n2)cc1 | 10.1021/jm990387k | ||
| CHEMBL434992 | 167879 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 487 | 7 | 1 | 6 | 6.3 | O=C(O)c1ccc(Cc2noc(-c3ccc4ccc(OCc5ccc6ccccc6n5)cc4c3)n2)cc1 | 10.1021/jm990387k | ||
| 10347819 | 22332 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 561 | 8 | 2 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)(C)C)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL132582 | 22332 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 561 | 8 | 2 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)(C)C)cc12 | 10.1021/jm00055a011 | ||
| 10415427 | 165034 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C)C)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL424257 | 165034 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C)C)cc12 | 10.1021/jm00055a011 | ||
| 15337934 | 106654 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 462 | 8 | 1 | 6 | 4.7 | c1cc(CCc2nnn[nH]2)c2c(c1)CCN2Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL316155 | 106654 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 462 | 8 | 1 | 6 | 4.7 | c1cc(CCc2nnn[nH]2)c2c(c1)CCN2Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1016/0960-894X(96)00013-3 | ||
| 19959108 | 204211 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 5.3 | C(=C/c1ccc2ccccc2n1)\c1cccc(CN2CCc3cccc(CCc4nnn[nH]4)c32)c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL84150 | 204211 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 5.3 | C(=C/c1ccc2ccccc2n1)\c1cccc(CN2CCc3cccc(CCc4nnn[nH]4)c32)c1 | 10.1016/0960-894X(96)00013-3 | ||
| 5059 | 204638 | 37 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL8747 | 204638 | 37 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 44277861 | 99073 | 0 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 395 | 5 | 1 | 3 | 5.7 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2CC[C@H]1Cc1ccccc1 | 10.1016/0960-894X(95)00225-I | ||
| CHEMBL283455 | 99073 | 0 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 395 | 5 | 1 | 3 | 5.7 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2CC[C@H]1Cc1ccccc1 | 10.1016/0960-894X(95)00225-I | ||
| 44278542 | 105523 | 0 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 4.4 | Cc1nc(COc2ccc3c(c2)[C@@H](O)[C@@H](Cc2cccnc2)CO3)ccc1Br | 10.1016/0960-894X(95)00226-J | ||
| CHEMBL31325 | 105523 | 0 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 4.4 | Cc1nc(COc2ccc3c(c2)[C@@H](O)[C@@H](Cc2cccnc2)CO3)ccc1Br | 10.1016/0960-894X(95)00226-J | ||
| 11293119 | 101128 | 37 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 422 | 6 | 2 | 5 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL298727 | 101128 | 37 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 422 | 6 | 2 | 5 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.6b01287 | ||
| 11293119 | 101128 | 37 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 422 | 6 | 2 | 5 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL298727 | 101128 | 37 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 422 | 6 | 2 | 5 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 10158417 | 66387 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18564 | 66387 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 15015299 | 98270 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1OCc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL277831 | 98270 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1OCc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 14750536 | 64298 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 331 | 6 | 1 | 5 | 3.1 | c1ccc2nc(COc3ccc(CCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL18177 | 64298 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 331 | 6 | 1 | 5 | 3.1 | c1ccc2nc(COc3ccc(CCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 9820486 | 66686 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 365 | 9 | 0 | 5 | 4.5 | CCOC(=O)CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18703 | 66686 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 365 | 9 | 0 | 5 | 4.5 | CCOC(=O)CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 14626829 | 100663 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 423 | 6 | 2 | 6 | 4.4 | COc1cc(C(=O)O)ccc1Cc1nn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL295268 | 100663 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 423 | 6 | 2 | 6 | 4.4 | COc1cc(C(=O)O)ccc1Cc1nn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 14708733 | 101441 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 408 | 6 | 2 | 5 | 4.9 | COc1cc(C(=O)O)ccc1Cn1ccc2ccc(NC(=O)OC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| CHEMBL300940 | 101441 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 408 | 6 | 2 | 5 | 4.9 | COc1cc(C(=O)O)ccc1Cn1ccc2ccc(NC(=O)OC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| 9800998 | 98909 | 1 | None | 32 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| CHEMBL282524 | 98909 | 1 | None | 32 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| 9800998 | 98909 | 1 | None | 32 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00226-J | ||
| CHEMBL282524 | 98909 | 1 | None | 32 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00226-J | ||
| 2812 | 4711 | 96 | None | -58 | 34 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
| CHEMBL104 | 4711 | 96 | None | -58 | 34 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
| 44352498 | 18224 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 466 | 6 | 2 | 6 | 4.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm990387k | ||
| CHEMBL127162 | 18224 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 466 | 6 | 2 | 6 | 4.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm990387k | ||
| 14774152 | 67324 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL19072 | 67324 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 10294833 | 98507 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 407 | 7 | 1 | 5 | 4.8 | c1cc(CCc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL279770 | 98507 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 407 | 7 | 1 | 5 | 4.8 | c1cc(CCc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 14650383 | 155300 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 375 | 8 | 1 | 6 | 3.6 | Cc1cc(OCc2ccc3ccccc3n2)ccc1OCCCc1nnn[nH]1 | 10.1021/jm00166a016 | ||
| CHEMBL406006 | 155300 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 375 | 8 | 1 | 6 | 3.6 | Cc1cc(OCc2ccc3ccccc3n2)ccc1OCCCc1nnn[nH]1 | 10.1021/jm00166a016 | ||
| 14650346 | 206308 | 1 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 8 | 1 | 5 | 3.9 | c1ccc2nc(COc3ccc(CCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL97541 | 206308 | 1 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 8 | 1 | 5 | 3.9 | c1ccc2nc(COc3ccc(CCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 44292186 | 100716 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 489 | 7 | 1 | 6 | 5.5 | O=C1CC(C(=O)O)Oc2ccc(Cl)c(OCc3ccc(OCc4ccc5ccccc5n4)cc3)c21 | 10.1021/jm00109a025 | ||
| CHEMBL295664 | 100716 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 489 | 7 | 1 | 6 | 5.5 | O=C1CC(C(=O)O)Oc2ccc(Cl)c(OCc3ccc(OCc4ccc5ccccc5n4)cc3)c21 | 10.1021/jm00109a025 | ||
| 10456871 | 59643 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | O=C(O)CCS[C@@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](O)C(=O)O | 10.1021/jm00389a001 | ||
| CHEMBL173289 | 59643 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | O=C(O)CCS[C@@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](O)C(=O)O | 10.1021/jm00389a001 | ||
| 14626841 | 192937 | 0 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 422 | 9 | 2 | 4 | 5.2 | CCCC(CC)C(=O)Nc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C | 10.1021/jm00168a037 | ||
| CHEMBL52906 | 192937 | 0 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 422 | 9 | 2 | 4 | 5.2 | CCCC(CC)C(=O)Nc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C | 10.1021/jm00168a037 | ||
| 44352235 | 18771 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 552 | 10 | 2 | 4 | 7.8 | CC(C(=O)Nc1ccc(CCCC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL128697 | 18771 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 552 | 10 | 2 | 4 | 7.8 | CC(C(=O)Nc1ccc(CCCC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 14626837 | 101117 | 0 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 408 | 9 | 2 | 4 | 5.0 | CCCCCC(=O)Nc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C | 10.1021/jm00168a037 | ||
| CHEMBL298642 | 101117 | 0 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 408 | 9 | 2 | 4 | 5.0 | CCCCCC(=O)Nc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C | 10.1021/jm00168a037 | ||
| 44285006 | 150500 | 0 | None | - | 1 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 456 | 15 | 3 | 4 | 5.8 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL39586 | 150500 | 0 | None | - | 1 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 456 | 15 | 3 | 4 | 5.8 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 2855 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | ||
| 3322 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | ||
| 5717 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | ||
| CHEMBL603 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | ||
| DB00549 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | ||
| 15015283 | 66681 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1ccc(OCc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18699 | 66681 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1ccc(OCc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00166a017 | ||
| 15675878 | 186962 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| CHEMBL49449 | 186962 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| 1836 | 2554 | 56 | None | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | ||
| 3340 | 2554 | 56 | None | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | ||
| 5281040 | 2554 | 56 | None | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | ||
| CHEMBL787 | 2554 | 56 | None | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | ||
| DB00471 | 2554 | 56 | None | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | ||
| 10100314 | 99565 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 613 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC/C(C)=C\C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL286885 | 99565 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 613 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC/C(C)=C\C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 10114089 | 67036 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2ccc(OCc3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18866 | 67036 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2ccc(OCc3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 10223216 | 67125 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18918 | 67125 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 10349047 | 96221 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 629 | 10 | 2 | 6 | 5.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL26384 | 96221 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 629 | 10 | 2 | 6 | 5.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 2855 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | ||
| 3322 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | ||
| 5717 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | ||
| CHEMBL603 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | ||
| DB00549 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | ||
| 44214127 | 18697 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 526 | 10 | 2 | 5 | 5.1 | O=C(O)Cc1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128317 | 18697 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 526 | 10 | 2 | 5 | 5.1 | O=C(O)Cc1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 10484810 | 95623 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 693 | 11 | 2 | 6 | 6.4 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3Br)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | ||
| CHEMBL26002 | 95623 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 693 | 11 | 2 | 6 | 6.4 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3Br)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | ||
| 22241529 | 67891 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 457 | 8 | 1 | 6 | 5.2 | Clc1ccc2ccc(COc3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a017 | ||
| CHEMBL19158 | 67891 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 457 | 8 | 1 | 6 | 5.2 | Clc1ccc2ccc(COc3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a017 | ||
| 44272197 | 166478 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 453 | 7 | 1 | 5 | 5.7 | Clc1ccc2ccc(/C=C/c3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a017 | ||
| CHEMBL428868 | 166478 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 453 | 7 | 1 | 5 | 5.7 | Clc1ccc2ccc(/C=C/c3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a017 | ||
| 15675872 | 178785 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 475 | 6 | 1 | 7 | 5.2 | O=C1CC(c2nnn[nH]2)Oc2cc(/C=C/c3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| CHEMBL47376 | 178785 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 475 | 6 | 1 | 7 | 5.2 | O=C1CC(c2nnn[nH]2)Oc2cc(/C=C/c3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| 14842364 | 122604 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 473 | 6 | 1 | 7 | 5.3 | O=c1cc(-c2nn[nH]n2)oc2cc(/C=C/c3cccc(OCc4ccc5ccccc5n4)c3)ccc12 | 10.1021/jm970180w | ||
| CHEMBL36113 | 122604 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 473 | 6 | 1 | 7 | 5.3 | O=c1cc(-c2nn[nH]n2)oc2cc(/C=C/c3cccc(OCc4ccc5ccccc5n4)c3)ccc12 | 10.1021/jm970180w | ||
| 10372164 | 23802 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 657 | 13 | 2 | 6 | 7.4 | CCC(CC)CNC(=O)c1ccc2c(CC3CCCCC3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL133788 | 23802 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 657 | 13 | 2 | 6 | 7.4 | CCC(CC)CNC(=O)c1ccc2c(CC3CCCCC3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 10077724 | 23336 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 629 | 12 | 2 | 6 | 6.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C1CCCC1 | 10.1021/jm00055a011 | ||
| CHEMBL133398 | 23336 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 629 | 12 | 2 | 6 | 6.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C1CCCC1 | 10.1021/jm00055a011 | ||
| 10348138 | 167730 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.6 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL434053 | 167730 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.6 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 10075131 | 18743 | 2 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 512 | 9 | 2 | 5 | 5.2 | O=C(O)c1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128583 | 18743 | 2 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 512 | 9 | 2 | 5 | 5.2 | O=C(O)c1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 9804436 | 20439 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1ccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL130846 | 20439 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1ccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 15015300 | 98054 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2ccc(-c3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL276136 | 98054 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2ccc(-c3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 10158418 | 65812 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18413 | 65812 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 9870702 | 99817 | 10 | None | 1 | 2 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 502 | 6 | 0 | 5 | 7.7 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)cc1 | 10.1016/0960-894X(95)00227-K | ||
| CHEMBL28902 | 99817 | 10 | None | 1 | 2 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 502 | 6 | 0 | 5 | 7.7 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)cc1 | 10.1016/0960-894X(95)00227-K | ||
| 14708738 | 189106 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 7 | 2 | 4 | 4.9 | COc1cc(C(=O)O)ccc1Cn1ccc2ccc(NC(=O)CC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| CHEMBL51544 | 189106 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 7 | 2 | 4 | 4.9 | COc1cc(C(=O)O)ccc1Cn1ccc2ccc(NC(=O)CC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| 44352288 | 116844 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 477 | 10 | 1 | 4 | 7.1 | O=C(O)c1ccc(CCCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL339716 | 116844 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 477 | 10 | 1 | 4 | 7.1 | O=C(O)c1ccc(CCCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 10225194 | 64935 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1OCc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a017 | ||
| CHEMBL18281 | 64935 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1OCc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a017 | ||
| 105007 | 96653 | 24 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00147a004 | ||
| CHEMBL267475 | 96653 | 24 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00147a004 | ||
| CHEMBL267976 | 96653 | 24 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00147a004 | ||
| 44277896 | 101216 | 0 | None | - | 1 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 4.0 | O[C@@H]1c2cc(OCc3cccc(Cl)n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00226-J | ||
| CHEMBL29937 | 101216 | 0 | None | - | 1 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 4.0 | O[C@@H]1c2cc(OCc3cccc(Cl)n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00226-J | ||
| 14626844 | 188297 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 408 | 6 | 3 | 4 | 5.0 | COc1cc(C(=O)O)ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL50733 | 188297 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 408 | 6 | 3 | 4 | 5.0 | COc1cc(C(=O)O)ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 44352209 | 18740 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 482 | 8 | 2 | 5 | 4.6 | O=C(O)c1ccc(CCNC(=O)C2CCc3ccc(OCc4ccc5ccccc5n4)cc3O2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128548 | 18740 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 482 | 8 | 2 | 5 | 4.6 | O=C(O)c1ccc(CCNC(=O)C2CCc3ccc(OCc4ccc5ccccc5n4)cc3O2)cc1 | 10.1021/jm990387k | ||
| 14650373 | 63846 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 367 | 8 | 1 | 7 | 3.4 | c1ccc2sc(COc3ccc(OCCCc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL18085 | 63846 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 367 | 8 | 1 | 7 | 3.4 | c1ccc2sc(COc3ccc(OCCCc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a016 | ||
| 14650381 | 65208 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 389 | 9 | 1 | 6 | 3.9 | CCc1ccc(OCc2ccc3ccccc3n2)cc1OCCCc1nnn[nH]1 | 10.1021/jm00166a016 | ||
| CHEMBL18309 | 65208 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 389 | 9 | 1 | 6 | 3.9 | CCc1ccc(OCc2ccc3ccccc3n2)cc1OCCCc1nnn[nH]1 | 10.1021/jm00166a016 | ||
| 10001437 | 99123 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 407 | 6 | 1 | 7 | 3.6 | Cc1nc(COc2ccc3c(c2)[C@@H](O)[C@@H](Cc2cccnc2)CO3)ccc1[N+](=O)[O-] | 10.1016/0960-894X(95)00226-J | ||
| CHEMBL283886 | 99123 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 407 | 6 | 1 | 7 | 3.6 | Cc1nc(COc2ccc3c(c2)[C@@H](O)[C@@H](Cc2cccnc2)CO3)ccc1[N+](=O)[O-] | 10.1016/0960-894X(95)00226-J | ||
| 9956127 | 168815 | 7 | None | - | 1 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 465 | 6 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2O)c1 | 10.1016/0960-894X(95)00225-I | ||
| CHEMBL442150 | 168815 | 7 | None | - | 1 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 465 | 6 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2O)c1 | 10.1016/0960-894X(95)00225-I | ||
| 126145 | 47589 | 7 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 488 | 18 | 2 | 4 | 7.2 | O=C(O)CCSC(SCCC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00147a004 | ||
| CHEMBL15489 | 47589 | 7 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 488 | 18 | 2 | 4 | 7.2 | O=C(O)CCSC(SCCC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00147a004 | ||
| 10258882 | 116024 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 665 | 14 | 2 | 6 | 7.1 | CCC(CC)CNC(=O)c1ccc2c(CCc3ccccc3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL336194 | 116024 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 665 | 14 | 2 | 6 | 7.1 | CCC(CC)CNC(=O)c1ccc2c(CCc3ccccc3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 44285389 | 99523 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](Sc1ccccc1C(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL286626 | 99523 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](Sc1ccccc1C(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| 10345753 | 204248 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 5.3 | Clc1ccc2ccc(COc3ccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)cc3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL84552 | 204248 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 5.3 | Clc1ccc2ccc(COc3ccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)cc3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| 44352484 | 21288 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 450 | 8 | 2 | 6 | 3.9 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131582 | 21288 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 450 | 8 | 2 | 6 | 3.9 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1021/jm990387k | ||
| 44285277 | 154223 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 512 | 19 | 3 | 4 | 7.4 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL40009 | 154223 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 512 | 19 | 3 | 4 | 7.4 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 44353198 | 20573 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 422 | 9 | 2 | 4 | 4.7 | CCCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC(C)C)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL130948 | 20573 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 422 | 9 | 2 | 4 | 4.7 | CCCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC(C)C)ccc12 | 10.1021/jm00055a011 | ||
| 44352125 | 116722 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 469 | 13 | 2 | 5 | 5.0 | O=C(Cc1ccc(OCCCCc2ccccc2)cc1)Nc1ccc(CCCc2nnn[nH]2)cc1 | 10.1021/jm990387k | ||
| CHEMBL339461 | 116722 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 469 | 13 | 2 | 5 | 5.0 | O=C(Cc1ccc(OCCCCc2ccccc2)cc1)Nc1ccc(CCCc2nnn[nH]2)cc1 | 10.1021/jm990387k | ||
| 9948863 | 67680 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 317 | 5 | 1 | 5 | 2.9 | c1ccc2nc(COc3ccc(Cc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL19136 | 67680 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 317 | 5 | 1 | 5 | 2.9 | c1ccc2nc(COc3ccc(Cc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 23224681 | 19286 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 486 | 7 | 2 | 6 | 5.1 | O=C(NCc1cccc(-c2nn[nH]n2)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL129893 | 19286 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 486 | 7 | 2 | 6 | 5.1 | O=C(NCc1cccc(-c2nn[nH]n2)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 14836105 | 11968 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 5.2 | C[C@H](C(=O)O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm00092a001 | ||
| CHEMBL1183712 | 11968 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 5.2 | C[C@H](C(=O)O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm00092a001 | ||
| CHEMBL314449 | 11968 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 5.2 | C[C@H](C(=O)O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm00092a001 | ||
| 3969 | 55612 | 40 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00168a037 | ||
| CHEMBL162358 | 55612 | 40 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00168a037 | ||
| 44352119 | 20626 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1cccc(-c2nn[nH]n2)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL131008 | 20626 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1cccc(-c2nn[nH]n2)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 44352157 | 19245 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 468 | 10 | 1 | 4 | 5.4 | CN(C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1)c1ccc(CCCC(=O)O)cc1 | 10.1021/jm990387k | ||
| CHEMBL129570 | 19245 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 468 | 10 | 1 | 4 | 5.4 | CN(C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1)c1ccc(CCCC(=O)O)cc1 | 10.1021/jm990387k | ||
| 129044 | 66067 | 18 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18518 | 66067 | 18 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00166a017 | ||
| 129044 | 66067 | 18 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00109a025 | ||
| CHEMBL18518 | 66067 | 18 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00109a025 | ||
| 10050711 | 109893 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 477 | 7 | 1 | 8 | 4.7 | O=c1cc(-c2nn[nH]n2)oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc12 | 10.1021/jm970180w | ||
| CHEMBL32426 | 109893 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 477 | 7 | 1 | 8 | 4.7 | O=c1cc(-c2nn[nH]n2)oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc12 | 10.1021/jm970180w | ||
| 129044 | 66067 | 18 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00108a001 | ||
| CHEMBL18518 | 66067 | 18 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00108a001 | ||
| 10438378 | 20792 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL131148 | 20792 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| 10438054 | 91774 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CCCC3)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL24256 | 91774 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CCCC3)cc12 | 10.1021/jm00055a011 | ||
| 10438054 | 91774 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CCCC3)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL24256 | 91774 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CCCC3)cc12 | 10.1021/jm00035a008 | ||
| 10223827 | 98015 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 419 | 7 | 1 | 5 | 5.1 | C(=C/c1ccc2ccccc2n1)\c1ccc(OCc2ccccc2Cc2nnn[nH]2)cc1 | 10.1021/jm00166a017 | ||
| CHEMBL275866 | 98015 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 419 | 7 | 1 | 5 | 5.1 | C(=C/c1ccc2ccccc2n1)\c1ccc(OCc2ccccc2Cc2nnn[nH]2)cc1 | 10.1021/jm00166a017 | ||
| 10074704 | 164753 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 5.1 | O=C(NCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| CHEMBL423333 | 164753 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 5.1 | O=C(NCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| 44352452 | 18759 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 540 | 9 | 2 | 5 | 5.9 | CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1 | 10.1021/jm990387k | ||
| CHEMBL128641 | 18759 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 540 | 9 | 2 | 5 | 5.9 | CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1 | 10.1021/jm990387k | ||
| 10348808 | 96157 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 613 | 10 | 2 | 6 | 5.4 | C=C(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | ||
| CHEMBL26332 | 96157 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 613 | 10 | 2 | 6 | 5.4 | C=C(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | ||
| 44353313 | 115966 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 639 | 11 | 2 | 6 | 6.1 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4Br)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL336101 | 115966 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 639 | 11 | 2 | 6 | 6.1 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4Br)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 44353268 | 116162 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 589 | 13 | 2 | 6 | 5.9 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL337059 | 116162 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 589 | 13 | 2 | 6 | 5.9 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| 44292483 | 175257 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 483 | 8 | 0 | 7 | 5.3 | CCOC(=O)C1CC(=O)c2ccc(COc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1 | 10.1021/jm00109a025 | ||
| CHEMBL45850 | 175257 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 483 | 8 | 0 | 7 | 5.3 | CCOC(=O)C1CC(=O)c2ccc(COc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1 | 10.1021/jm00109a025 | ||
| 44352385 | 18785 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 516 | 6 | 2 | 6 | 6.0 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| CHEMBL128771 | 18785 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 516 | 6 | 2 | 6 | 6.0 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| 44352384 | 19160 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 458 | 6 | 1 | 4 | 6.7 | O=C(O)c1ccc2c(ccn2Cc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1021/jm990387k | ||
| CHEMBL129079 | 19160 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 458 | 6 | 1 | 4 | 6.7 | O=C(O)c1ccc2c(ccn2Cc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1021/jm990387k | ||
| 44352326 | 20648 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3cc(OCc4ccc5ccccc5n4)ccc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131025 | 20648 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3cc(OCc4ccc5ccccc5n4)ccc3c2)cc1 | 10.1021/jm990387k | ||
| 10223215 | 65281 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1ccc2nc(COc3ccc(COc4ccc(-c5nn[nH]n5)cc4)cc3)ccc2c1 | 10.1021/jm00166a017 | ||
| CHEMBL18339 | 65281 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1ccc2nc(COc3ccc(COc4ccc(-c5nn[nH]n5)cc4)cc3)ccc2c1 | 10.1021/jm00166a017 | ||
| 14650348 | 64898 | 1 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 377 | 8 | 1 | 6 | 4.1 | c1ccc2nc(COc3ccc(SCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL18265 | 64898 | 1 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 377 | 8 | 1 | 6 | 4.1 | c1ccc2nc(COc3ccc(SCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 14650342 | 98400 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 476 | 10 | 1 | 6 | 4.5 | O=C(CCCOc1ccc(OCc2ccc3ccccc3n2)cc1)NS(=O)(=O)c1ccccc1 | 10.1021/jm00166a016 | ||
| CHEMBL278920 | 98400 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 476 | 10 | 1 | 6 | 4.5 | O=C(CCCOc1ccc(OCc2ccc3ccccc3n2)cc1)NS(=O)(=O)c1ccccc1 | 10.1021/jm00166a016 | ||
| 15337938 | 204194 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 492 | 7 | 1 | 5 | 5.9 | Clc1ccc2ccc(/C=C/c3ccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)cc3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL84025 | 204194 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 492 | 7 | 1 | 5 | 5.9 | Clc1ccc2ccc(/C=C/c3ccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)cc3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| 44285563 | 152918 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 528 | 20 | 3 | 5 | 7.2 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCOc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL39794 | 152918 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 528 | 20 | 3 | 5 | 7.2 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCOc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 44285014 | 162091 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 498 | 18 | 3 | 4 | 7.0 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL416973 | 162091 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 498 | 18 | 3 | 4 | 7.0 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 14501729 | 65889 | 0 | None | - | 1 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1ccc(OCc2ccc3ccccc3n2)c(OCCCc2nnn[nH]2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18450 | 65889 | 0 | None | - | 1 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1ccc(OCc2ccc3ccccc3n2)c(OCCCc2nnn[nH]2)c1 | 10.1021/jm00166a016 | ||
| 9848518 | 106806 | 2 | None | 1 | 2 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 492 | 6 | 0 | 6 | 7.2 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3nc4cc(F)ccc4s3)c2)cc1 | 10.1016/0960-894X(95)00227-K | ||
| CHEMBL31714 | 106806 | 2 | None | 1 | 2 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 492 | 6 | 0 | 6 | 7.2 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3nc4cc(F)ccc4s3)c2)cc1 | 10.1016/0960-894X(95)00227-K | ||
| 44352109 | 116183 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 516 | 8 | 4 | 7 | 5.2 | CC(C(=O)Nc1ccc(CC2=NNNN2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL337162 | 116183 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 516 | 8 | 4 | 7 | 5.2 | CC(C(=O)Nc1ccc(CC2=NNNN2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 60539 | 59676 | 5 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 382 | 5 | 1 | 4 | 4.1 | O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F | 10.1021/jm00166a017 | ||
| CHEMBL17344 | 59676 | 5 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 382 | 5 | 1 | 4 | 4.1 | O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F | 10.1021/jm00166a017 | ||
| 60539 | 59676 | 5 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 382 | 5 | 1 | 4 | 4.1 | O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F | 10.1021/jm00108a001 | ||
| CHEMBL17344 | 59676 | 5 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 382 | 5 | 1 | 4 | 4.1 | O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F | 10.1021/jm00108a001 | ||
| 44352450 | 19279 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL129866 | 19279 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 44352264 | 18734 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 456 | 10 | 2 | 4 | 5.4 | CC(C(=O)NCCCCC(=O)O)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL128531 | 18734 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 456 | 10 | 2 | 4 | 5.4 | CC(C(=O)NCCCCC(=O)O)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 129968 | 162704 | 11 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL418551 | 162704 | 11 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 44352354 | 18667 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 518 | 10 | 2 | 4 | 7.1 | CC(C(=O)Nc1ccc(CCCC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL128164 | 18667 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 518 | 10 | 2 | 4 | 7.1 | CC(C(=O)Nc1ccc(CCCC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 14650340 | 66848 | 1 | None | - | 1 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 307 | 7 | 0 | 3 | 5.0 | CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18775 | 66848 | 1 | None | - | 1 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 307 | 7 | 0 | 3 | 5.0 | CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 44352172 | 116047 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 6 | 5.5 | O=C(O)c1ccc(OCC(O)COc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL336298 | 116047 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 6 | 5.5 | O=C(O)c1ccc(OCC(O)COc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 44352462 | 114879 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(Cc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| CHEMBL335000 | 114879 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(Cc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| 10394121 | 99329 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 621 | 10 | 2 | 6 | 5.8 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cn1ccc2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| CHEMBL285300 | 99329 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 621 | 10 | 2 | 6 | 5.8 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cn1ccc2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| 15015281 | 66443 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1COc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18589 | 66443 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1COc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 44352294 | 162889 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1cccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1021/jm990387k | ||
| CHEMBL419796 | 162889 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1cccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1021/jm990387k | ||
| 10416524 | 92856 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 627 | 10 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3(CC(F)(F)F)CC3)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL24506 | 92856 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 627 | 10 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3(CC(F)(F)F)CC3)cc12 | 10.1021/jm00035a008 | ||
| 9985579 | 98679 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00035a008 | ||
| CHEMBL281066 | 98679 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00035a008 | ||
| 9870130 | 18804 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 488 | 10 | 2 | 4 | 6.1 | O=C(O)CCCc1ccc(NC(=O)Cc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128794 | 18804 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 488 | 10 | 2 | 4 | 6.1 | O=C(O)CCCc1ccc(NC(=O)Cc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc2)cc1 | 10.1021/jm990387k | ||
| 10416647 | 99163 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 635 | 10 | 2 | 6 | 6.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cn1cc(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| CHEMBL284128 | 99163 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 635 | 10 | 2 | 6 | 6.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cn1cc(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| 9952064 | 67212 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 385 | 7 | 1 | 4 | 5.1 | O=C(O)c1cccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18979 | 67212 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 385 | 7 | 1 | 4 | 5.1 | O=C(O)c1cccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c1 | 10.1021/jm00166a017 | ||
| 44352118 | 21068 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 454 | 10 | 2 | 4 | 5.4 | O=C(O)CCCc1ccc(NC(=O)Cc2cccc(OCc3ccc4ccccc4n3)c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131345 | 21068 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 454 | 10 | 2 | 4 | 5.4 | O=C(O)CCCc1ccc(NC(=O)Cc2cccc(OCc3ccc4ccccc4n3)c2)cc1 | 10.1021/jm990387k | ||
| 6917955 | 79507 | 1 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc([C@@H](O)[C@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| CHEMBL21247 | 79507 | 1 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc([C@@H](O)[C@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| 44286706 | 14447 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | ||
| CHEMBL1205015 | 14447 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | ||
| CHEMBL41301 | 14447 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | ||
| 14626846 | 188109 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.1 | COCCn1cc(Cc2ccc(C(=O)O)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1021/jm00168a037 | ||
| CHEMBL50422 | 188109 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.1 | COCCn1cc(Cc2ccc(C(=O)O)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1021/jm00168a037 | ||
| 44382463 | 58912 | 0 | None | 9 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| CHEMBL170226 | 58912 | 0 | None | 9 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| 129968 | 162704 | 11 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL418551 | 162704 | 11 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 44352142 | 18665 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 454 | 10 | 2 | 4 | 5.2 | O=C(O)CCCc1ccc(C(=O)NCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128151 | 18665 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 454 | 10 | 2 | 4 | 5.2 | O=C(O)CCCc1ccc(C(=O)NCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1021/jm990387k | ||
| 126144 | 46141 | 6 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 468 | 20 | 2 | 4 | 7.6 | CCCCCCCCCCCCc1ccccc1C(SCCC(=O)O)SCCC(=O)O | 10.1021/jm00147a004 | ||
| CHEMBL15367 | 46141 | 6 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 468 | 20 | 2 | 4 | 7.6 | CCCCCCCCCCCCc1ccccc1C(SCCC(=O)O)SCCC(=O)O | 10.1021/jm00147a004 | ||
| 3334 | 3098 | 7 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | ||
| 60842 | 3098 | 7 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | ||
| CHEMBL22776 | 3098 | 7 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | ||
| 3334 | 3098 | 7 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00108a001 | ||
| 60842 | 3098 | 7 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00108a001 | ||
| CHEMBL22776 | 3098 | 7 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00108a001 | ||
| 3334 | 3098 | 7 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00168a037 | ||
| 60842 | 3098 | 7 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00168a037 | ||
| CHEMBL22776 | 3098 | 7 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00168a037 | ||
| 10461845 | 99555 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 643 | 12 | 2 | 6 | 6.3 | CCCCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)C(F)(F)F | 10.1021/jm00035a008 | ||
| CHEMBL286827 | 99555 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 643 | 12 | 2 | 6 | 6.3 | CCCCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)C(F)(F)F | 10.1021/jm00035a008 | ||
| 14948496 | 93047 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | CCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL24613 | 93047 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | CCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 9870316 | 204038 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 492 | 7 | 1 | 5 | 5.9 | Clc1ccc2ccc(/C=C/c3cccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL82758 | 204038 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 492 | 7 | 1 | 5 | 5.9 | Clc1ccc2ccc(/C=C/c3cccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| 15337936 | 204202 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 494 | 7 | 1 | 6 | 5.7 | Clc1ccc2ccc(/C=C/c3cccc(CN4CCc5cccc(OCc6nn[nH]n6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL84089 | 204202 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 494 | 7 | 1 | 6 | 5.7 | Clc1ccc2ccc(/C=C/c3cccc(CN4CCc5cccc(OCc6nn[nH]n6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| 14948496 | 93047 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | CCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00035a008 | ||
| CHEMBL24613 | 93047 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | CCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00035a008 | ||
| 9909426 | 66963 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18833 | 66963 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 10031940 | 19277 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 629 | 11 | 2 | 6 | 5.9 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | ||
| CHEMBL12985 | 19277 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 629 | 11 | 2 | 6 | 5.9 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | ||
| 10394230 | 60720 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 629 | 11 | 2 | 6 | 6.0 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CC)C(F)(F)F | 10.1021/jm00035a008 | ||
| CHEMBL176286 | 60720 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 629 | 11 | 2 | 6 | 6.0 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CC)C(F)(F)F | 10.1021/jm00035a008 | ||
| 10481103 | 18651 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 5.0 | O=C(Cc1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128068 | 18651 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 5.0 | O=C(Cc1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1021/jm990387k | ||
| 9847235 | 21020 | 3 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 463 | 9 | 1 | 4 | 6.7 | O=C(O)c1ccc(CCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131304 | 21020 | 3 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 463 | 9 | 1 | 4 | 6.7 | O=C(O)c1ccc(CCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 14708752 | 187104 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 407 | 7 | 2 | 5 | 4.3 | COc1cc(C(=O)O)ccc1Cn1ncc2ccc(NC(=O)CC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| CHEMBL49519 | 187104 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 407 | 7 | 2 | 5 | 4.3 | COc1cc(C(=O)O)ccc1Cn1ncc2ccc(NC(=O)CC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| 10371402 | 21228 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 601 | 12 | 2 | 6 | 6.3 | C/C=C\c1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL131514 | 21228 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 601 | 12 | 2 | 6 | 6.3 | C/C=C\c1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| 9890545 | 204166 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 462 | 8 | 1 | 6 | 4.7 | c1cc(CN2CCc3cccc(CCc4nnn[nH]4)c32)cc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL83851 | 204166 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 462 | 8 | 1 | 6 | 4.7 | c1cc(CN2CCc3cccc(CCc4nnn[nH]4)c32)cc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(96)00013-3 | ||
| 14650371 | 65915 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 362 | 8 | 1 | 7 | 2.7 | c1ccc2nc(COc3ccc(OCCCc4nnn[nH]4)cc3)ncc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL18459 | 65915 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 362 | 8 | 1 | 7 | 2.7 | c1ccc2nc(COc3ccc(OCCCc4nnn[nH]4)cc3)ncc2c1 | 10.1021/jm00166a016 | ||
| 9951001 | 65981 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 365 | 9 | 0 | 5 | 4.5 | CCOC(=O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | ||
| CHEMBL18490 | 65981 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 365 | 9 | 0 | 5 | 4.5 | CCOC(=O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | ||
| 44285448 | 120593 | 0 | None | - | 1 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 568 | 23 | 3 | 4 | 8.9 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL35731 | 120593 | 0 | None | - | 1 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 568 | 23 | 3 | 4 | 8.9 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 105007 | 96653 | 24 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a017 | ||
| CHEMBL267475 | 96653 | 24 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a017 | ||
| CHEMBL267976 | 96653 | 24 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a017 | ||
| 105007 | 96653 | 24 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00109a025 | ||
| CHEMBL267475 | 96653 | 24 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00109a025 | ||
| CHEMBL267976 | 96653 | 24 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00109a025 | ||
| 14650359 | 67549 | 1 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 377 | 8 | 1 | 6 | 4.1 | c1ccc2nc(CSc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL19106 | 67549 | 1 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 377 | 8 | 1 | 6 | 4.1 | c1ccc2nc(CSc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 6518171 | 167733 | 49 | None | -4 | 8 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 495 | 12 | 2 | 6 | 4.9 | CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 | nan | ||
| CHEMBL434063 | 167733 | 49 | None | -4 | 8 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 495 | 12 | 2 | 6 | 4.9 | CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 | nan | ||
| 14626845 | 164372 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 450 | 8 | 2 | 5 | 5.8 | CCCn1cc(Cc2ccc(C(=O)O)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1021/jm00168a037 | ||
| CHEMBL422404 | 164372 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 450 | 8 | 2 | 5 | 5.8 | CCCn1cc(Cc2ccc(C(=O)O)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1021/jm00168a037 | ||
| 44352130 | 21222 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.8 | O=C(Nc1ccc(CCCc2nnn[nH]2)cc1)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131502 | 21222 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.8 | O=C(Nc1ccc(CCCc2nnn[nH]2)cc1)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm990387k | ||
| 15675886 | 100674 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2cc(COc3ccc(OCc4ccc5ccccc5n4)cc3)ccc21 | 10.1021/jm00109a025 | ||
| CHEMBL295368 | 100674 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2cc(COc3ccc(OCc4ccc5ccccc5n4)cc3)ccc21 | 10.1021/jm00109a025 | ||
| 10482604 | 19573 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 547 | 9 | 2 | 6 | 4.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)C)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL130140 | 19573 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 547 | 9 | 2 | 6 | 4.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)C)cc12 | 10.1021/jm00055a011 | ||
| 44353314 | 23425 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 595 | 11 | 2 | 6 | 5.9 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4Cl)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL133462 | 23425 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 595 | 11 | 2 | 6 | 5.9 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4Cl)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 10438821 | 116977 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 617 | 13 | 2 | 6 | 6.5 | CCC(CC)CNC(=O)c1ccc2c(CC(C)C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL339958 | 116977 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 617 | 13 | 2 | 6 | 6.5 | CCC(CC)CNC(=O)c1ccc2c(CC(C)C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 10325810 | 22189 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL132449 | 22189 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 10461263 | 161188 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL413742 | 161188 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 6436135 | 99111 | 39 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 412 | 9 | 2 | 4 | 5.8 | CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O | 10.1021/jm970180w | ||
| CHEMBL283754 | 99111 | 39 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 412 | 9 | 2 | 4 | 5.8 | CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O | 10.1021/jm970180w | ||
| 9803418 | 60147 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 442 | 16 | 2 | 3 | 6.5 | O=C(O)CCSC(CC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00389a001 | ||
| CHEMBL175401 | 60147 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 442 | 16 | 2 | 3 | 6.5 | O=C(O)CCSC(CC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00389a001 | ||
| 9868007 | 81038 | 3 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 442 | 16 | 2 | 3 | 6.5 | O=C(O)CCS[C@@H](CC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00108a001 | ||
| CHEMBL21595 | 81038 | 3 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 442 | 16 | 2 | 3 | 6.5 | O=C(O)CCS[C@@H](CC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00108a001 | ||
| 3969 | 55612 | 40 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00092a001 | ||
| CHEMBL162358 | 55612 | 40 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00092a001 | ||
| 3969 | 55612 | 40 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| CHEMBL162358 | 55612 | 40 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| 10437821 | 116022 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 561 | 9 | 1 | 6 | 4.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)N(C)CC(C)C)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL336183 | 116022 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 561 | 9 | 1 | 6 | 4.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)N(C)CC(C)C)cc12 | 10.1021/jm00055a011 | ||
| 10026794 | 20000 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 450 | 11 | 2 | 4 | 5.5 | CCCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL130495 | 20000 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 450 | 11 | 2 | 4 | 5.5 | CCCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| 44285289 | 100031 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 514 | 19 | 3 | 5 | 6.8 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCOc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL291032 | 100031 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 514 | 19 | 3 | 5 | 6.8 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCOc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 9885950 | 97940 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 375 | 8 | 1 | 6 | 3.6 | Cc1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL275385 | 97940 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 375 | 8 | 1 | 6 | 3.6 | Cc1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 9800998 | 98909 | 1 | None | 32 | 2 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00225-I | ||
| CHEMBL282524 | 98909 | 1 | None | 32 | 2 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00225-I | ||
| 44352422 | 116087 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 490 | 8 | 2 | 4 | 6.1 | CC(C(=O)NCc1cccc(C(=O)O)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL336606 | 116087 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 490 | 8 | 2 | 4 | 6.1 | CC(C(=O)NCc1cccc(C(=O)O)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 10808580 | 99705 | 0 | None | - | 1 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 5.6 | CCCCC1CCc2ccc(OCc3ccc4ccccc4n3)cc2C1O | 10.1016/0960-894X(95)00225-I | ||
| CHEMBL28797 | 99705 | 0 | None | - | 1 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 5.6 | CCCCC1CCc2ccc(OCc3ccc4ccccc4n3)cc2C1O | 10.1016/0960-894X(95)00225-I | ||
| 9906952 | 206259 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1ccc2nc(COc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL97287 | 206259 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1ccc2nc(COc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 44272233 | 98521 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL279849 | 98521 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 10202522 | 65795 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(OCc2ccc(Cc3nnn[nH]3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18405 | 65795 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(OCc2ccc(Cc3nnn[nH]3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 44352148 | 18623 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 449 | 8 | 1 | 4 | 6.4 | O=C(O)c1ccc(COCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL127842 | 18623 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 449 | 8 | 1 | 4 | 6.4 | O=C(O)c1ccc(COCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 44352151 | 18704 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 454 | 10 | 2 | 4 | 5.4 | O=C(O)CCCc1ccc(NC(=O)Cc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128364 | 18704 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 454 | 10 | 2 | 4 | 5.4 | O=C(O)CCCc1ccc(NC(=O)Cc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1021/jm990387k | ||
| 10348846 | 96082 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C)C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL26284 | 96082 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C)C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 44272084 | 65784 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(OCc2ccc(OCc3ccc4ccccc4n3)cc2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18396 | 65784 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(OCc2ccc(OCc3ccc4ccccc4n3)cc2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 10371399 | 95303 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 601 | 10 | 2 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCCC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL25841 | 95303 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 601 | 10 | 2 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCCC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 10348586 | 99190 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 601 | 10 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1ccc2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| CHEMBL284322 | 99190 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 601 | 10 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1ccc2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| 23224651 | 18724 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 486 | 7 | 2 | 6 | 5.1 | O=C(NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| CHEMBL128477 | 18724 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 486 | 7 | 2 | 6 | 5.1 | O=C(NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| 44353320 | 164479 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 561 | 11 | 2 | 6 | 5.2 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(C(=O)NCC(C)C)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL422616 | 164479 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 561 | 11 | 2 | 6 | 5.2 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(C(=O)NCC(C)C)ccc12 | 10.1021/jm00055a011 | ||
| 10100380 | 20830 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 617 | 14 | 2 | 6 | 6.5 | CCCCCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL131173 | 20830 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 617 | 14 | 2 | 6 | 6.5 | CCCCCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 44352424 | 20819 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 490 | 8 | 2 | 4 | 6.1 | CC(C(=O)NCc1ccc(C(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL131166 | 20819 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 490 | 8 | 2 | 4 | 6.1 | CC(C(=O)NCc1ccc(C(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 44292283 | 176695 | 0 | None | - | 1 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 347 | 4 | 1 | 5 | 3.6 | O=C(O)c1cc(=O)c2ccc(OCc3ccc4ccccc4n3)cc2o1 | 10.1021/jm00109a025 | ||
| CHEMBL46362 | 176695 | 0 | None | - | 1 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 347 | 4 | 1 | 5 | 3.6 | O=C(O)c1cc(=O)c2ccc(OCc3ccc4ccccc4n3)cc2o1 | 10.1021/jm00109a025 | ||
| 44278454 | 99422 | 0 | None | -2 | 2 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 468 | 6 | 0 | 5 | 7.0 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccccc4n3)c2)cc1 | 10.1016/0960-894X(95)00227-K | ||
| CHEMBL28595 | 99422 | 0 | None | -2 | 2 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 468 | 6 | 0 | 5 | 7.0 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccccc4n3)c2)cc1 | 10.1016/0960-894X(95)00227-K | ||
| 9820984 | 66378 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 375 | 9 | 1 | 6 | 3.7 | c1cc(OCCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18558 | 66378 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 375 | 9 | 1 | 6 | 3.7 | c1cc(OCCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 44352316 | 22054 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 502 | 9 | 2 | 4 | 6.2 | O=C(O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc(-c5ccccc5)cn4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL132341 | 22054 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 502 | 9 | 2 | 4 | 6.2 | O=C(O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc(-c5ccccc5)cn4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 10031428 | 20474 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 595 | 10 | 2 | 6 | 5.2 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCc3ccccc3)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL130873 | 20474 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 595 | 10 | 2 | 6 | 5.2 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCc3ccccc3)cc12 | 10.1021/jm00055a011 | ||
| 10371435 | 116426 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 603 | 13 | 1 | 6 | 6.2 | CCCCN(CCCC)C(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL338497 | 116426 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 603 | 13 | 1 | 6 | 6.2 | CCCCN(CCCC)C(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 9932067 | 66461 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18597 | 66461 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | ||
| 9827188 | 67127 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 497 | 10 | 1 | 9 | 4.3 | COC(=O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c(OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18919 | 67127 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 497 | 10 | 1 | 9 | 4.3 | COC(=O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c(OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 10114090 | 67180 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18956 | 67180 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 44352103 | 116190 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccccc1CC(=O)O | 10.1021/jm990387k | ||
| CHEMBL337195 | 116190 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccccc1CC(=O)O | 10.1021/jm990387k | ||
| 10222948 | 65751 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 405 | 6 | 1 | 5 | 5.2 | C(=C/c1cccc(-c2nn[nH]n2)c1)\c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18381 | 65751 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 405 | 6 | 1 | 5 | 5.2 | C(=C/c1cccc(-c2nn[nH]n2)c1)\c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 15015282 | 66936 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc2nc(COc3ccc(OCc4ccc(Cc5nnn[nH]5)cc4)cc3)ccc2c1 | 10.1021/jm00166a017 | ||
| CHEMBL18816 | 66936 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc2nc(COc3ccc(OCc4ccc(Cc5nnn[nH]5)cc4)cc3)ccc2c1 | 10.1021/jm00166a017 | ||
| 14708751 | 186722 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 409 | 6 | 2 | 6 | 4.3 | COc1cc(C(=O)O)ccc1Cn1ncc2ccc(NC(=O)OC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| CHEMBL49298 | 186722 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 409 | 6 | 2 | 6 | 4.3 | COc1cc(C(=O)O)ccc1Cn1ncc2ccc(NC(=O)OC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| 14626842 | 101578 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 420 | 7 | 2 | 4 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL301928 | 101578 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 420 | 7 | 2 | 4 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 105007 | 96653 | 24 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| CHEMBL267475 | 96653 | 24 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| CHEMBL267976 | 96653 | 24 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| 5059 | 204638 | 37 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(95)00226-J | ||
| CHEMBL8747 | 204638 | 37 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(95)00226-J | ||
| 5059 | 204638 | 37 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(95)00225-I | ||
| CHEMBL8747 | 204638 | 37 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(95)00225-I | ||
| 14650343 | 63776 | 1 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 333 | 6 | 1 | 6 | 2.9 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2nn[nH]n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18081 | 63776 | 1 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 333 | 6 | 1 | 6 | 2.9 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2nn[nH]n2)c1 | 10.1021/jm00166a016 | ||
| 44352397 | 20996 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 504 | 7 | 2 | 8 | 4.0 | O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c(=O)cc(-c3nn[nH]n3)oc12 | 10.1021/jm990387k | ||
| CHEMBL131287 | 20996 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 504 | 7 | 2 | 8 | 4.0 | O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c(=O)cc(-c3nn[nH]n3)oc12 | 10.1021/jm990387k | ||
| 44286706 | 14447 | 0 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | ||
| CHEMBL1205015 | 14447 | 0 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | ||
| CHEMBL41301 | 14447 | 0 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | ||
| 44352159 | 19172 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 478 | 10 | 2 | 6 | 4.7 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)Nc1ccc(CCCc2nnn[nH]2)cc1 | 10.1021/jm990387k | ||
| CHEMBL129142 | 19172 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 478 | 10 | 2 | 6 | 4.7 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)Nc1ccc(CCCc2nnn[nH]2)cc1 | 10.1021/jm990387k | ||
| 448537 | 159703 | 86 | None | -41 | 25 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | nan | ||
| CHEMBL411 | 159703 | 86 | None | -41 | 25 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | nan | ||
| 44352186 | 21866 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 478 | 7 | 2 | 5 | 6.4 | O=C(Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)OCc1ccc(C(=O)O)cc1 | 10.1021/jm990387k | ||
| CHEMBL132167 | 21866 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 478 | 7 | 2 | 5 | 6.4 | O=C(Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)OCc1ccc(C(=O)O)cc1 | 10.1021/jm990387k | ||
| 44352154 | 164474 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL422609 | 164474 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 10156907 | 67531 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 385 | 7 | 1 | 4 | 5.1 | O=C(O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc1 | 10.1021/jm00166a017 | ||
| CHEMBL19102 | 67531 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 385 | 7 | 1 | 4 | 5.1 | O=C(O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc1 | 10.1021/jm00166a017 | ||
| 105007 | 96653 | 24 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a016 | ||
| CHEMBL267475 | 96653 | 24 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a016 | ||
| CHEMBL267976 | 96653 | 24 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a016 | ||
| 10346 | 2522 | 40 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10391245 | ||
| 5281888 | 2522 | 40 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10391245 | ||
| CHEMBL15177 | 2522 | 40 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10391245 | ||
| 6193 | 3921 | 33 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | ||
| 6509849 | 3921 | 33 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | ||
| CHEMBL280481 | 3921 | 33 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | ||
| 3353 | 2338 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3353 | 2338 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 16306225 | ||
| 3412 | 2338 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3412 | 2338 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 16306225 | ||
| 6435286 | 2338 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 6435286 | 2338 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 16306225 | ||
| CHEMBL1521056 | 2338 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| CHEMBL1521056 | 2338 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 16306225 | ||
| 3353 | 2338 | 0 | None | 21 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| 3412 | 2338 | 0 | None | 21 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| 6435286 | 2338 | 0 | None | 21 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| CHEMBL1521056 | 2338 | 0 | None | 21 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| 3353 | 2338 | 0 | None | 21 | 2 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | None | ||
| 3412 | 2338 | 0 | None | 21 | 2 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | None | ||
| 6435286 | 2338 | 0 | None | 21 | 2 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | None | ||
| CHEMBL1521056 | 2338 | 0 | None | 21 | 2 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | None | ||
| 3353 | 2338 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9504401 | ||
| 3353 | 2338 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | ||
| 3412 | 2338 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9504401 | ||
| 3412 | 2338 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | ||
| 6435286 | 2338 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9504401 | ||
| 6435286 | 2338 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | ||
| CHEMBL1521056 | 2338 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9504401 | ||
| CHEMBL1521056 | 2338 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | ||
| 115219 | 1947 | 10 | None | 489 | 3 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | ||
| 3358 | 1947 | 10 | None | 489 | 3 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | ||
| 3414 | 1947 | 10 | None | 489 | 3 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | ||
| CHEMBL22033 | 1947 | 10 | None | 489 | 3 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | ||
| 2855 | 4069 | 100 | 3H-LTD4 | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 3322 | 4069 | 100 | 3H-LTD4 | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 5717 | 4069 | 100 | 3H-LTD4 | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| CHEMBL603 | 4069 | 100 | 3H-LTD4 | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| DB00549 | 4069 | 100 | 3H-LTD4 | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| None | 214468 | 0 | 3H-LTD4 | 95 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 514 | 11 | 1 | 5 | 6.5 | CN(C)C(=O)CCSC(C1=CC=CC(=C1)C=CC2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)O | None | ||
| None | 214455 | 0 | 3H-LTD4 | 2187 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 473 | 7 | 2 | 3 | 7.9 | CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)S)O | None | ||
| 2812 | 4711 | 96 | None | 1 | 34 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
| 2812 | 4711 | 96 | None | -58 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
| CHEMBL104 | 4711 | 96 | None | 1 | 34 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
| CHEMBL104 | 4711 | 96 | None | -58 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
| 57340263 | 214467 | 0 | 3H-LTD4 | -1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C/C=C/C=C/[C@H]([C@H](CCCC(=O)O)O)SC1=CC=C(C=C1)C(=O)O | None | ||
| 448537 | 159703 | 86 | None | 15 | 25 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | None | ||
| 448537 | 159703 | 86 | None | -41 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | None | ||
| CHEMBL411 | 159703 | 86 | None | 15 | 25 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | None | ||
| CHEMBL411 | 159703 | 86 | None | -41 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | None | ||
| 6436135 | 99111 | 39 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 9 | 2 | 4 | 5.8 | CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O | None | ||
| CHEMBL283754 | 99111 | 39 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 9 | 2 | 4 | 5.8 | CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O | None | ||
| 2237 | 3113 | 73 | None | 4 | 3 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| 3634 | 3113 | 73 | None | 4 | 3 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| 4887 | 3113 | 73 | None | 4 | 3 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| CHEMBL21333 | 3113 | 73 | None | 4 | 3 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| DB01411 | 3113 | 73 | None | 4 | 3 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| 1836 | 2554 | 56 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| 3340 | 2554 | 56 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| 5281040 | 2554 | 56 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| CHEMBL787 | 2554 | 56 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| DB00471 | 2554 | 56 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| 1836 | 2554 | 56 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| 3340 | 2554 | 56 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| 5281040 | 2554 | 56 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| CHEMBL787 | 2554 | 56 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| DB00471 | 2554 | 56 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| 2855 | 4069 | 100 | None | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 3322 | 4069 | 100 | None | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 5717 | 4069 | 100 | None | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| DB00549 | 4069 | 100 | None | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 2855 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 3322 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 5717 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| CHEMBL603 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| DB00549 | 4069 | 100 | None | -1 | 6 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 3352 | 2339 | 25 | None | -15 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | ||
| 5280879 | 2339 | 25 | None | -15 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | ||
| 5863 | 2339 | 25 | None | -15 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | ||
| CHEMBL509456 | 2339 | 25 | None | -15 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | ||
| 3354 | 2337 | 24 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 9547367 | ||
| 5280493 | 2337 | 24 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 9547367 | ||
| CHEMBL451509 | 2337 | 24 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 9547367 | ||
| DB08855 | 2337 | 24 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 9547367 | ||
| 5861 | 2034 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | Guide to Pharmacology | 710 | 16 | 3 | 8 | 8.9 | CCCc1c(OCCCC/C=C\C=C\[C@@H]([C@@H](c2cccc(c2)C(F)(F)F)O)Sc2ccc3c(c2)oc(cc3=O)C(=O)O)ccc(c1O)C(=O)C | 9504401 | ||
| 6913104 | 2034 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | Guide to Pharmacology | 710 | 16 | 3 | 8 | 8.9 | CCCc1c(OCCCC/C=C\C=C\[C@@H]([C@@H](c2cccc(c2)C(F)(F)F)O)Sc2ccc3c(c2)oc(cc3=O)C(=O)O)ccc(c1O)C(=O)C | 9504401 | ||
| CHEMBL1206833 | 2034 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | Guide to Pharmacology | 710 | 16 | 3 | 8 | 8.9 | CCCc1c(OCCCC/C=C\C=C\[C@@H]([C@@H](c2cccc(c2)C(F)(F)F)O)Sc2ccc3c(c2)oc(cc3=O)C(=O)O)ccc(c1O)C(=O)C | 9504401 | ||
| 3327 | 3649 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 472 | 17 | 3 | 6 | 5.7 | CCCCCCCCC/C=C\C=C\[C@H]([C@H](c1cccc(c1)c1nnn[nH]1)O)SCCC(=O)O | None | ||
| 6436123 | 3649 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 472 | 17 | 3 | 6 | 5.7 | CCCCCCCCC/C=C\C=C\[C@H]([C@H](c1cccc(c1)c1nnn[nH]1)O)SCCC(=O)O | None | ||
| CHEMBL278570 | 3649 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 472 | 17 | 3 | 6 | 5.7 | CCCCCCCCC/C=C\C=C\[C@H]([C@H](c1cccc(c1)c1nnn[nH]1)O)SCCC(=O)O | None | ||
| 128355 | 3612 | 27 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | None | ||
| 3329 | 3612 | 27 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | None | ||
| CHEMBL18132 | 3612 | 27 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | None | ||
| 115219 | 1947 | 10 | None | -489 | 3 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 2170649 | ||
| 3358 | 1947 | 10 | None | -489 | 3 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 2170649 | ||
| 3414 | 1947 | 10 | None | -489 | 3 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 2170649 | ||
| CHEMBL22033 | 1947 | 10 | None | -489 | 3 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 2170649 | ||
| 3334 | 3098 | 7 | None | -5 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 9547367 | ||
| 60842 | 3098 | 7 | None | -5 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 9547367 | ||
| CHEMBL22776 | 3098 | 7 | None | -5 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 9547367 | ||
| 2237 | 3113 | 73 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | ||
| 2237 | 3113 | 73 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | ||
| 3634 | 3113 | 73 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | ||
| 3634 | 3113 | 73 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | ||
| 4887 | 3113 | 73 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | ||
| 4887 | 3113 | 73 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | ||
| CHEMBL21333 | 3113 | 73 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | ||
| CHEMBL21333 | 3113 | 73 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | ||
| DB01411 | 3113 | 73 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | ||
| DB01411 | 3113 | 73 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | ||
| 1836 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | ||
| 3340 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | ||
| 5281040 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | ||
| CHEMBL787 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | ||
| DB00471 | 2554 | 56 | None | -1 | 15 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | ||
| 2855 | 4069 | 100 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | ||
| 2855 | 4069 | 100 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | ||
| 3322 | 4069 | 100 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | ||
| 3322 | 4069 | 100 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | ||
| 5717 | 4069 | 100 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | ||
| 5717 | 4069 | 100 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | ||
| CHEMBL603 | 4069 | 100 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | ||
| DB00549 | 4069 | 100 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | ||
| DB00549 | 4069 | 100 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | ||