Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
155531953 171180 0 None -2 3 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4467290 171180 0 None -2 3 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155563693 174822 0 None 36 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4575422 174822 0 None 36 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
11332190 896 10 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 896 10 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 896 10 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
11332190 896 10 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 896 10 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 896 10 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5088494 213389 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155538662 171851 0 None 2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4476788 171851 0 None 2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5088494 213389 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5082551 213037 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.0c01804
168275711 189623 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 635 11 2 9 6.0 Cc1ccc(-c2nc(=O)s[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc(C(=O)NS(=O)(=O)C4CC4)c(C4CC4)s3)cc2)c1 10.1016/j.bmc.2021.116587
CHEMBL5174724 189623 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 635 11 2 9 6.0 Cc1ccc(-c2nc(=O)s[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc(C(=O)NS(=O)(=O)C4CC4)c(C4CC4)s3)cc2)c1 10.1016/j.bmc.2021.116587
168293038 191525 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 613 10 2 9 5.3 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(=O)(=O)C1CC1 10.1016/j.bmc.2021.116587
CHEMBL5203480 191525 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 613 10 2 9 5.3 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(=O)(=O)C1CC1 10.1016/j.bmc.2021.116587
CHEMBL5077507 212730 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5077507 212730 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5082551 213037 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.0c01804
168291719 191361 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 587 9 2 9 4.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(C)(=O)=O 10.1016/j.bmc.2021.116587
CHEMBL5200919 191361 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 587 9 2 9 4.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(C)(=O)=O 10.1016/j.bmc.2021.116587
168269858 189382 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 642 13 2 8 6.2 CCONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5170854 189382 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 642 13 2 8 6.2 CCONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
168292803 191465 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5202580 191465 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
168292522 191444 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 639 11 2 9 5.9 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5202223 191444 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 639 11 2 9 5.9 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155519637 169854 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448308 169854 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155530073 170926 0 None 10 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4463797 170926 0 None 10 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155519352 169873 2 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 169873 2 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5085505 213197 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5085505 213197 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5080998 212942 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCc1ccccc1 10.1021/acs.jmedchem.0c01804
CHEMBL5080998 212942 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCc1ccccc1 10.1021/acs.jmedchem.0c01804
CHEMBL5092307 213584 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
168286108 190794 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 510 8 2 7 5.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)O 10.1016/j.bmc.2021.116587
CHEMBL5192437 190794 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 510 8 2 7 5.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)O 10.1016/j.bmc.2021.116587
168284015 190657 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5190234 190657 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5092307 213584 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155537257 171701 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4474605 171701 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
155548932 173250 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4538515 173250 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
168280867 190169 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 601 10 2 9 5.2 CCS(=O)(=O)NC(=O)c1nc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)sc1C 10.1016/j.bmc.2021.116587
CHEMBL5183095 190169 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 601 10 2 9 5.2 CCS(=O)(=O)NC(=O)c1nc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)sc1C 10.1016/j.bmc.2021.116587
155544237 172795 0 None 3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4527534 172795 0 None 3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
11936 973 4 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 10.1016/j.bmc.2021.116587
162679547 973 4 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 10.1016/j.bmc.2021.116587
CHEMBL5180985 973 4 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 10.1016/j.bmc.2021.116587
168282236 190369 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 628 12 2 8 5.8 CONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5185986 190369 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 628 12 2 8 5.8 CONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
155535518 171502 0 None 4 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472121 171502 0 None 4 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5092307 213584 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155535988 171543 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472664 171543 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5082981 213063 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5082981 213063 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155518713 169713 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4446260 169713 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL5089041 213419 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(N)=O 10.1021/acs.jmedchem.0c01804
CHEMBL5089041 213419 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(N)=O 10.1021/acs.jmedchem.0c01804
CHEMBL5092307 213584 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5088494 213389 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5088494 213389 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155538284 171833 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4476545 171833 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
155569501 175618 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
CHEMBL4593522 175618 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
11332190 896 10 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 896 10 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 896 10 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
11332190 896 10 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 896 10 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 896 10 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
155554828 174048 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4557657 174048 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5082981 213063 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5082981 213063 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
162649940 179415 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746987 179415 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
162656586 180315 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 530 8 2 7 6.2 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
CHEMBL4757632 180315 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 530 8 2 7 6.2 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
162674241 182634 0 None - 1 Human 8.0 pIC50 = 8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 518 9 1 8 6.4 CCCCN(c1nc2c(-c3nccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4796012 182634 0 None - 1 Human 8.0 pIC50 = 8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 518 9 1 8 6.4 CCCCN(c1nc2c(-c3nccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162671889 182275 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(F)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4791599 182275 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(F)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
168284015 190657 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5190234 190657 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155548932 173250 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4538515 173250 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
162654876 180007 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 8 2 7 5.5 C[C@H](c1ccc(-c2ccccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
CHEMBL4754349 180007 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 8 2 7 5.5 C[C@H](c1ccc(-c2ccccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
155531953 171180 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4467290 171180 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162655374 180228 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2c(C(=O)NC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4756747 180228 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2c(C(=O)NC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162677428 182914 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4799609 182914 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155531953 171180 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4467290 171180 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
168292803 191465 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5202580 191465 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155519637 169854 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448308 169854 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155519969 169796 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 492 8 1 6 6.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(Cl)c2o1 10.1016/j.bmc.2019.115091
CHEMBL4447627 169796 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 492 8 1 6 6.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(Cl)c2o1 10.1016/j.bmc.2019.115091
162649290 179581 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 509 9 1 7 5.7 CCCCN(c1nc2c(C(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4748968 179581 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 509 9 1 7 5.7 CCCCN(c1nc2c(C(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162663355 181328 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 517 9 1 7 7.0 CCCCN(c1nc2c(-c3cccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4779379 181328 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 517 9 1 7 7.0 CCCCN(c1nc2c(-c3cccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162654668 179347 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(-c3nnn[nH]3)cccc2C(F)(F)F)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746196 179347 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(-c3nnn[nH]3)cccc2C(F)(F)F)cc1 10.1016/j.bmc.2020.115622
162654348 180024 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C(F)(F)F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4754530 180024 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C(F)(F)F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162648650 179314 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 531 10 2 8 5.4 CCCCN(c1nc2c(NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4745883 179314 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 531 10 2 8 5.4 CCCCN(c1nc2c(NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162660049 180778 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 559 10 2 9 4.7 CCCCN(c1nc2c(C(=O)NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4763169 180778 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 559 10 2 9 4.7 CCCCN(c1nc2c(C(=O)NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
168282945 190164 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1681 55 6 25 8.6 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCn2nnc3c2-c2ccccc2N(C(=O)CCNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]4NC(=O)N[C@@H]42)Cc2ccccc2-3)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5183004 190164 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1681 55 6 25 8.6 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCn2nnc3c2-c2ccccc2N(C(=O)CCNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]4NC(=O)N[C@@H]42)Cc2ccccc2-3)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155519352 169873 2 None 1 2 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 169873 2 None 1 2 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155531953 171180 0 None 2 3 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4467290 171180 0 None 2 3 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162659559 180709 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(F)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4762253 180709 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(F)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162671930 182322 2 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 9 2 7 5.7 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4792296 182322 2 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 9 2 7 5.7 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162673878 182406 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 514 8 2 7 5.7 C[C@H](c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
CHEMBL4793378 182406 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 514 8 2 7 5.7 C[C@H](c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
162673026 182486 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 516 9 2 7 6.0 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4794289 182486 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 516 9 2 7 6.0 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
162657219 180288 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(C)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4757393 180288 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(C)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155538662 171851 0 None -2 2 Mouse 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4476788 171851 0 None -2 2 Mouse 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162654669 179348 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(C)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746197 179348 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(C)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162649970 179479 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2c(NC(C)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4747813 179479 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2c(NC(C)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155569501 175618 0 None -1 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
CHEMBL4593522 175618 0 None -1 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
162653266 179821 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 2 7 5.5 CCCCN(c1nc2c(CO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4752027 179821 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 2 7 5.5 CCCCN(c1nc2c(CO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155543662 172637 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 10 1 8 5.2 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4522836 172637 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 10 1 8 5.2 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
155530073 170926 0 None 10 2 Human 6.6 pIC50 = 6.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4463797 170926 0 None 10 2 Human 6.6 pIC50 = 6.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155537257 171701 0 None 2 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4474605 171701 0 None 2 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
155567133 175306 0 None 1 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(C)c2o1 10.1016/j.bmc.2019.115091
CHEMBL4586253 175306 0 None 1 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(C)c2o1 10.1016/j.bmc.2019.115091
162671660 182300 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 539 11 2 8 5.1 CCCCN(c1nc2c(C(=O)N(C)CCO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4791896 182300 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 539 11 2 8 5.1 CCCCN(c1nc2c(C(=O)N(C)CCO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162661813 180874 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 453 8 2 7 5.6 CCCCN(c1nc2c(N)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4764426 180874 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 453 8 2 7 5.6 CCCCN(c1nc2c(N)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155526368 170579 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 459 7 1 7 5.3 c1ccc(CN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2nc3ccccc3o2)nc1 10.1016/j.bmc.2019.115091
CHEMBL4458521 170579 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 459 7 1 7 5.3 c1ccc(CN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2nc3ccccc3o2)nc1 10.1016/j.bmc.2019.115091
162662697 181408 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 10 1 7 6.2 CCCCN(c1nc2c(COC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4780439 181408 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 10 1 7 6.2 CCCCN(c1nc2c(COC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162641724 181675 4 None - 1 Human 8.5 pIC50 = 8.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
CHEMBL4783675 181675 4 None - 1 Human 8.5 pIC50 = 8.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
162652190 179765 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccncc3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4751327 179765 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccncc3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162670503 182384 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(OC)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4793031 182384 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(OC)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155554828 174048 0 None -1 2 Mouse 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4557657 174048 0 None -1 2 Mouse 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162654920 179983 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2c(NC(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4754029 179983 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2c(NC(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155535988 171543 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472664 171543 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162674418 182667 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 504 9 1 8 6.2 CCCCN(c1nc2c(-n3cccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4796399 182667 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 504 9 1 8 6.2 CCCCN(c1nc2c(-n3cccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155518713 169713 0 None 2 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4446260 169713 0 None 2 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
155538284 171833 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4476545 171833 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
155550367 173718 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)c(C)cc2o1 10.1016/j.bmc.2019.115091
CHEMBL4549880 173718 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)c(C)cc2o1 10.1016/j.bmc.2019.115091
155554828 174048 0 None 1 2 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4557657 174048 0 None 1 2 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162649458 179483 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 9 2 7 6.3 CCCCN(c1nc2c(C(C)(C)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4747865 179483 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 9 2 7 6.3 CCCCN(c1nc2c(C(C)(C)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155550204 173279 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 426 8 1 7 4.3 COCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4539132 173279 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 426 8 1 7 4.3 COCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
162645029 178883 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(Cl)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4740735 178883 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(Cl)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155544237 172795 0 None 3 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4527534 172795 0 None 3 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155519352 169873 2 None -1 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 169873 2 None -1 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
168276231 189828 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 626 12 2 7 6.3 CCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5177967 189828 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 626 12 2 7 6.3 CCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
155564611 174952 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 482 9 1 8 5.3 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4578235 174952 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 482 9 1 8 5.3 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
155538662 171851 0 None 2 2 Human 6.4 pIC50 = 6.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4476788 171851 0 None 2 2 Human 6.4 pIC50 = 6.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155563693 174822 0 None 36 2 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4575422 174822 0 None 36 2 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155544237 172795 0 None -3 2 Mouse 6.3 pIC50 = 6.3 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4527534 172795 0 None -3 2 Mouse 6.3 pIC50 = 6.3 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
168286341 191095 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 682 16 2 7 7.9 CCCCCCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5196772 191095 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 682 16 2 7 7.9 CCCCCCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
162668192 181848 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4786002 181848 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162653225 179820 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(F)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4752019 179820 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(F)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162647018 178955 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 523 10 1 7 6.1 CCCCN(c1nc2c(C(=O)N(C)CC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4741497 178955 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 523 10 1 7 6.1 CCCCN(c1nc2c(C(=O)N(C)CC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162672104 182276 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4791613 182276 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162648558 179327 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746011 179327 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155525712 170508 0 None 1 2 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4457246 170508 0 None 1 2 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155516007 169464 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)C(C)(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4442745 169464 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)C(C)(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162675068 182693 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(OC)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4796678 182693 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(OC)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
168294228 191626 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1263 36 3 18 8.8 CCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCOCCOCCOCCNC(=O)c3ccc(Cl)cc3-c3ccc([C@@H](C)N(CC4CC4)c4nc(C(=O)NS(=O)(=O)C5CC5)c(C5CC5)s4)cc3)c2-c2ccccc21 10.1016/j.bmc.2021.116587
CHEMBL5204898 191626 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1263 36 3 18 8.8 CCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCOCCOCCOCCNC(=O)c3ccc(Cl)cc3-c3ccc([C@@H](C)N(CC4CC4)c4nc(C(=O)NS(=O)(=O)C5CC5)c(C5CC5)s4)cc3)c2-c2ccccc21 10.1016/j.bmc.2021.116587
155563693 174822 0 None -36 2 Mouse 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4575422 174822 0 None -36 2 Mouse 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155535518 171502 0 None 4 2 Human 6.0 pIC50 = 6.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472121 171502 0 None 4 2 Human 6.0 pIC50 = 6.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
2945 895 0 None -14 2 Human 8.0 pEC50 = 8.0 Functional
In a β-arrestin recruitment assay.In a β-arrestin recruitment assay.
Guide to Pharmacology None None None None 25437209
2945 895 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14530373
2945 895 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
2945 895 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
2945 895 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23396314
1518 365 1 None 85 3 Human 6.4 pIC50 = 6.4 Functional
Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.
Guide to Pharmacology 242 4 0 1 3.1 O=C(c1cccc2c1cccc2)CC[N+](C)(C)C 25437209
9781 365 1 None 85 3 Human 6.4 pIC50 = 6.4 Functional
Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.
Guide to Pharmacology 242 4 0 1 3.1 O=C(c1cccc2c1cccc2)CC[N+](C)(C)C 25437209
CHEMBL1358898 365 1 None 85 3 Human 6.4 pIC50 = 6.4 Functional
Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.
Guide to Pharmacology 242 4 0 1 3.1 O=C(c1cccc2c1cccc2)CC[N+](C)(C)C 25437209
12979 3384 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Determined in h<i>CMKLR1</i>-transfected CHO cells, measuring antagonism of agonist-induced intracellular calcium mobilisationDetermined in h<i>CMKLR1</i>-transfected CHO cells, measuring antagonism of agonist-induced intracellular calcium mobilisation
Guide to Pharmacology 570 9 2 5 7.9 C[C@@H](CC(O)=O)C1=CC=C(OCC2=CC3=C(C(=NN3C4CCCC4)C5=CC(Cl)=C(CO)C(Cl)=C5)C(F)=C2)C=C1 37883692
12980 2257 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 442 8 1 5 5.6 CC(C)N1N=C(C2=C1C=C(COC3=CC=C(C=C3)[C@H](C)C(=O)C(O)=O)C=C2)C4=CC=CC=C4 37883692
11936 973 4 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 35063894
162679547 973 4 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 35063894
CHEMBL5180985 973 4 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 35063894


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
162649940 179415 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746987 179415 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
155519352 169873 2 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 169873 2 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162641724 181675 4 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
CHEMBL4783675 181675 4 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
9784 3728 0 None - 0 Human 8.3 pIC50 ~ 8.3 Binding
Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.
Guide to Pharmacology None None None None 14530373
9784 3728 0 None - 0 Human 8.3 pIC50 ~ 8.3 Binding
Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.
Guide to Pharmacology None None None None 24659779
11332190 896 10 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
11332190 896 10 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
3422 896 10 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
3422 896 10 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
CHEMBL5081975 896 10 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
CHEMBL5081975 896 10 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
10473088 3267 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
10473088 3267 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
10473088 3267 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
3333 3267 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
3333 3267 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
3333 3267 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
CHEMBL1742483 3267 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
CHEMBL1742483 3267 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
CHEMBL1742483 3267 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
DB13105 3267 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
DB13105 3267 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
DB13105 3267 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
2945 895 0 None 1 2 Human 8.3 pKd = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312