Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
44377942 57153 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 530 6 2 5 5.9 O=S(=O)(Nc1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1)C(F)(F)F 10.1021/jm1013693
CHEMBL165572 57153 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 530 6 2 5 5.9 O=S(=O)(Nc1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1)C(F)(F)F 10.1021/jm1013693
44355628 24702 0 None -5 2 Rat 6.0 pIC50 = 6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
CHEMBL134567 24702 0 None -5 2 Rat 6.0 pIC50 = 6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
10411653 24220 0 None -208 2 Rat 5.0 pIC50 = 5 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 5 1 5 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O 10.1021/jm00078a013
CHEMBL134151 24220 0 None -208 2 Rat 5.0 pIC50 = 5 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 5 1 5 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O 10.1021/jm00078a013
10410730 24414 0 None -6 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
CHEMBL134307 24414 0 None -6 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
10048220 25984 0 None -109 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL135704 25984 0 None -109 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
10322995 114764 0 None -134 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 482 9 1 5 6.1 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C 10.1021/jm00078a014
CHEMBL334832 114764 0 None -134 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 482 9 1 5 6.1 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C 10.1021/jm00078a014
10003482 165190 0 None -158 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL424643 165190 0 None -158 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
10364891 26040 0 None -33 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 421 5 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 10.1021/jm00078a013
CHEMBL135792 26040 0 None -33 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 421 5 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 10.1021/jm00078a013
192345 26031 6 None -12022 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL135775 26031 6 None -12022 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10393397 22597 0 None -6 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 578 8 1 5 7.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
CHEMBL132807 22597 0 None -6 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 578 8 1 5 7.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
10367704 22143 0 None -25 2 Rat 6.9 pIC50 = 6.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL132408 22143 0 None -25 2 Rat 6.9 pIC50 = 6.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10094520 24554 0 None -11 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
CHEMBL134433 24554 0 None -11 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
15698118 204423 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 537 10 2 6 5.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm1013693
CHEMBL86067 204423 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 537 10 2 6 5.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm1013693
44355660 21357 0 None -89 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL131676 21357 0 None -89 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
11743704 114999 0 None -3 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 10.1021/jm00078a013
CHEMBL335179 114999 0 None -3 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 10.1021/jm00078a013
10026268 116430 0 None -173 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 440 6 1 5 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 10.1021/jm00078a013
CHEMBL338505 116430 0 None -173 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 440 6 1 5 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 10.1021/jm00078a013
10322504 26178 0 None -19 2 Rat 5.8 pIC50 = 5.8 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135929 26178 0 None -19 2 Rat 5.8 pIC50 = 5.8 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10095493 25843 0 None -93 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
CHEMBL135521 25843 0 None -93 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
11754335 25099 0 None -186 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 467 5 2 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 10.1021/jm00078a013
CHEMBL134901 25099 0 None -186 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 467 5 2 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 10.1021/jm00078a013
1610 2315 89 None -8 9 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
3941 2315 89 None -8 9 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
3961 2315 89 None -8 9 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
590 2315 89 None -8 9 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
CHEMBL191 2315 89 None -8 9 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
DB00678 2315 89 None -8 9 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
44355662 26258 0 None -125 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL135999 26258 0 None -125 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
10411101 165113 0 None -676 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 2 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 10.1021/jm00078a014
CHEMBL424465 165113 0 None -676 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 2 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 10.1021/jm00078a014
19742811 57120 0 None 1 3 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
CHEMBL165354 57120 0 None 1 3 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
130762 97795 9 None 1 6 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm1013693
CHEMBL274447 97795 9 None 1 6 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm1013693
192567 116152 6 None -223 2 Rat 6.7 pIC50 = 6.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL337007 116152 6 None -223 2 Rat 6.7 pIC50 = 6.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
10366811 24622 0 None -31 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 10.1021/jm00078a014
CHEMBL134491 24622 0 None -31 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 10.1021/jm00078a014
11744592 115004 0 None -33 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 6 0 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 10.1021/jm00078a013
CHEMBL335228 115004 0 None -33 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 6 0 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 10.1021/jm00078a013
10409549 115478 0 None -104 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 414 7 2 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL335514 115478 0 None -104 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 414 7 2 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10027636 24390 0 None -70 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL134286 24390 0 None -70 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
71455883 83350 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1021/jm1013693
CHEMBL2205685 83350 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1021/jm1013693
10048602 25845 0 None -37 2 Rat 4.6 pIC50 = 4.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 4 0 5 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N 10.1021/jm00078a013
CHEMBL135522 25845 0 None -37 2 Rat 4.6 pIC50 = 4.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 4 0 5 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N 10.1021/jm00078a013
9914666 116170 0 None -3388 2 Rat 5.6 pIC50 = 5.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL337086 116170 0 None -3388 2 Rat 5.6 pIC50 = 5.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
9846535 57211 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 427 5 2 4 5.4 O=C(O)c1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1 10.1021/jm1013693
CHEMBL166143 57211 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 427 5 2 4 5.4 O=C(O)c1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1 10.1021/jm1013693
10326140 116151 0 None -2884 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL337006 116151 0 None -2884 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
10365283 25649 0 None -416 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135345 25649 0 None -416 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10393717 115599 0 None -524 2 Rat 6.4 pIC50 = 6.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL335722 115599 0 None -524 2 Rat 6.4 pIC50 = 6.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
10344571 116114 0 None -125 2 Rat 5.4 pIC50 = 5.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336773 116114 0 None -125 2 Rat 5.4 pIC50 = 5.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10027714 114938 0 None -398 2 Rat 5.3 pIC50 = 5.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL335066 114938 0 None -398 2 Rat 5.3 pIC50 = 5.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10004112 25326 0 None -93 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL135089 25326 0 None -93 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10344052 116107 0 None -107 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 9 1 5 5.7 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336738 116107 0 None -107 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 9 1 5 5.7 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10437543 26062 0 None -7 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 550 7 2 5 6.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
CHEMBL135819 26062 0 None -7 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 550 7 2 5 6.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
10414429 115497 0 None -363 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 522 5 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O 10.1021/jm00078a013
CHEMBL335535 115497 0 None -363 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 522 5 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O 10.1021/jm00078a013
10434876 116118 0 None -7 2 Rat 6.2 pIC50 = 6.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 10 1 5 6.1 CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336808 116118 0 None -7 2 Rat 6.2 pIC50 = 6.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 10 1 5 6.1 CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10026868 23655 0 None -331 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 5 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL133653 23655 0 None -331 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 5 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 10.1021/jm00078a013
10456041 25651 0 None -186 2 Rat 6.1 pIC50 = 6.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 8 1 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135346 25651 0 None -186 2 Rat 6.1 pIC50 = 6.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 8 1 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10095589 115020 0 None -851 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL335289 115020 0 None -851 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
10345459 116270 0 None -43 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 490 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F 10.1021/jm00078a014
CHEMBL337663 116270 0 None -43 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 490 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F 10.1021/jm00078a014
10250898 117984 0 None -37 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 408 4 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 10.1021/jm00078a013
CHEMBL341407 117984 0 None -37 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 408 4 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 10.1021/jm00078a013
10071193 202621 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonism against A-2 induced contraction of aortic rings of rabbit.Antagonism against A-2 induced contraction of aortic rings of rabbit.
ChEMBL 427 7 1 4 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc([C@H](c2ccccc2)[C@H](C)C(=O)O)cc1 10.1021/jm9508853
CHEMBL71485 202621 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonism against A-2 induced contraction of aortic rings of rabbit.Antagonism against A-2 induced contraction of aortic rings of rabbit.
ChEMBL 427 7 1 4 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc([C@H](c2ccccc2)[C@H](C)C(=O)O)cc1 10.1021/jm9508853
6918 1013 29 None -7 2 Human 8.7 pKi = 8.7 Functional
Agonist activity at AT2 receptor in HEK293 cellsAgonist activity at AT2 receptor in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116790
9804984 1013 29 None -7 2 Human 8.7 pKi = 8.7 Functional
Agonist activity at AT2 receptor in HEK293 cellsAgonist activity at AT2 receptor in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116790
CHEMBL189568 1013 29 None -7 2 Human 8.7 pKi = 8.7 Functional
Agonist activity at AT2 receptor in HEK293 cellsAgonist activity at AT2 receptor in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116790
6918 1013 29 None -7 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
9804984 1013 29 None -7 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
CHEMBL189568 1013 29 None -7 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
6918 1013 29 None 7 2 Rat 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
9804984 1013 29 None 7 2 Rat 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
CHEMBL189568 1013 29 None 7 2 Rat 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
1610 2315 89 None -309 9 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2315 89 None -309 9 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2315 89 None -309 9 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2315 89 None -309 9 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2315 89 None -309 9 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2315 89 None -309 9 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
36736 3418 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
598 3418 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
6324663 3418 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
CHEMBL356431 3418 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
123805 413 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
46878481 413 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
5578 413 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
582 413 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
CHEMBL3545347 413 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
DB11720 413 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
8374 2877 36 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
9937291 2877 36 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
CHEMBL34124 2877 36 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
DB16266 2877 36 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
8374 2877 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
8374 2877 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
8374 2877 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
9937291 2877 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
9937291 2877 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
9937291 2877 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
CHEMBL34124 2877 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
CHEMBL34124 2877 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
CHEMBL34124 2877 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
DB16266 2877 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
DB16266 2877 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
DB16266 2877 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
114899 2971 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2314387
114899 2971 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2590220
114899 2971 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 8469774
596 2971 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2314387
596 2971 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2590220
596 2971 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 8469774
CHEMBL1188080 2971 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2314387
CHEMBL1188080 2971 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2590220
CHEMBL1188080 2971 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 8469774
36736 3418 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
598 3418 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
6324663 3418 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
CHEMBL356431 3418 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
123794 880 40 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
3944 880 40 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
594 880 40 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
CHEMBL1885579 880 40 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
6894 414 0 None 2 3 Human 9.9 pIC50 = 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17138938
91691124 414 0 None 2 3 Human 9.9 pIC50 = 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17138938


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
44348523 112680 0 None - 0 Rat 10.3 pIC50 = 10.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 112680 0 None - 0 Rat 10.3 pIC50 = 10.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
11930 1004 0 None - 2 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
15780052 1004 0 None - 2 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
CHEMBL289472 1004 0 None - 2 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
10033116 206495 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL98665 206495 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
11765177 116507 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 116507 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
16133225 415 47 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
172198 415 47 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
2504 415 47 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
45266664 415 47 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
5272 415 47 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL408403 415 47 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
DB11842 415 47 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL385433 210603 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP42112A from human recombinant AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP42112A from human recombinant AT2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2016.03.006
10259841 15982 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 15982 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10417195 108592 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321313 108592 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
10078554 116467 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 116467 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10440174 167251 0 None - 0 Rat 10.0 pIC50 = 10 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 767 17 1 9 8.0 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL430659 167251 0 None - 0 Rat 10.0 pIC50 = 10 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 767 17 1 9 8.0 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL385189 210596 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cccs1)C(=O)O 10.1021/jm00108a043
10078800 108704 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissuesInhibitory concentration against AT1 receptor from rat adrenal tissues
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 108704 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissuesInhibitory concentration against AT1 receptor from rat adrenal tissues
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
9853391 116339 1 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 116339 1 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
9853391 116339 1 None - 0 Human 9.9 pIC50 = 9.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm9504722
CHEMBL338027 116339 1 None - 0 Human 9.9 pIC50 = 9.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm9504722
CHEMBL2391146 208667 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human angiotensin AT2 receptor by radioligand displacement assayBinding affinity to human angiotensin AT2 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
10101351 168099 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 168099 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259525 15443 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 15443 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10372810 105721 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL313868 105721 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
10078800 108704 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 108704 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10395335 116581 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 116581 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10033136 15897 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 15897 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
19430477 206390 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 8.1 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 10.1021/jm00015a016
CHEMBL98047 206390 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 8.1 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 10.1021/jm00015a016
10259468 117977 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 117977 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101606 15595 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 15595 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10032988 116417 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116417 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10440179 106915 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL317962 106915 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10078780 116416 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 116416 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259468 117977 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 117977 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259265 109554 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissues.Inhibitory concentration against AT1 receptor from rat adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 109554 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissues.Inhibitory concentration against AT1 receptor from rat adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10372659 117587 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 117587 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10327728 97671 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 97671 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10078554 116467 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 116467 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10033116 206495 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL98665 206495 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
44348523 112680 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 112680 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
10032877 15374 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 15374 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
183134 203136 13 None - 1 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL7550 203136 13 None - 1 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10259525 15443 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 15443 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10010071 116846 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 116846 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292111 203037 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 203037 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL2392353 208669 6 None - 1 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to human AT2 receptor by radioligand displacement assayBinding affinity to human AT2 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
10033136 15897 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 15897 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10439837 16177 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 16177 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
10032820 116801 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 116801 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
9853391 116339 1 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 116339 1 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101690 116361 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 116361 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10440144 116394 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 116394 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10439715 116534 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 116534 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44314761 102381 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 102381 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
44315344 104602 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 104602 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315078 203048 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 203048 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
15780085 117647 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL34082 117647 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10440144 116394 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 116394 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10032988 116417 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116417 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101351 168099 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 168099 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315078 203048 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 203048 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10033126 167574 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL433005 167574 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10078780 116416 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 116416 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10372451 116791 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 116791 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462683 112783 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 112783 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44283480 100002 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 9 1 8 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL290768 100002 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 9 1 8 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10259265 109554 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 109554 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10259265 109554 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL323506 109554 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462933 16702 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 16702 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
19754068 102260 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 13 2 7 7.2 CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL304946 102260 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 13 2 7 7.2 CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C 10.1016/S0960-894X(01)81115-X
10101606 15595 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 15595 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10101608 116528 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 116528 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
44315282 96176 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 96176 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
44315351 104406 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 104406 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
9896750 4116 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm00015a016
CHEMBL100119 4116 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm00015a016
10372550 163964 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 163964 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439715 116534 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 116534 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9987414 116548 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 116548 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
11765177 116507 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 116507 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10032851 16656 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16656 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44314761 102381 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 102381 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
9896750 4116 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm9504722
CHEMBL100119 4116 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm9504722
10032877 15374 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 15374 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10009984 112681 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 112681 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
10078475 112831 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 112831 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9987414 116548 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 116548 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10010164 116894 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 116894 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765560 15362 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 15362 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314822 102476 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 102476 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9895877 53606 1 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 653 12 2 8 7.1 CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm9504722
CHEMBL160494 53606 1 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 653 12 2 8 7.1 CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm9504722
10439858 16682 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 16682 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259447 16747 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 16747 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
10010071 116846 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 116846 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292111 203037 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 203037 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19754061 102261 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
CHEMBL304947 102261 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
10462573 116508 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 116508 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10395335 116581 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 116581 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
44315349 60071 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 60071 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10394859 17247 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 17247 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
2583 3717 115 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
592 3717 115 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
65999 3717 115 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
CHEMBL1017 3717 115 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
DB00966 3717 115 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
10373120 117098 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 117098 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
10394859 17247 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 17247 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315351 104406 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 104406 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
15780090 99989 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 631 9 1 7 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL290669 99989 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 631 9 1 7 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10101608 116528 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 116528 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10259841 15982 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 15982 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10372659 117587 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 117587 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314822 102476 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 102476 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10373120 117098 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 117098 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
44315144 96144 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 96144 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10032851 16656 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16656 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395076 168011 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168011 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9874508 202974 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 202974 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9874508 202974 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1021/jm9504722
CHEMBL73876 202974 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1021/jm9504722
44338708 109955 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL324629 109955 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
22850667 199116 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 542 11 1 3 6.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL60071 199116 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 542 11 1 3 6.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10032820 116801 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 116801 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10462683 112783 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 112783 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44314823 161338 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 161338 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL938 214130 24 None -1 2 Human 9.4 pIC50 = 9.4 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm8007618
9809637 202154 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68618 202154 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
9830680 100176 0 None - 1 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
CHEMBL292150 100176 0 None - 1 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
15780094 99349 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 651 9 1 7 7.4 CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL285433 99349 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 651 9 1 7 7.4 CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL384352 210577 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CCSS2 10.1021/jm00065a013
9917295 102485 13 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL306407 102485 13 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
10417321 15442 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 15442 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439819 169322 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 169322 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292113 95587 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 95587 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10078800 108704 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 108704 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10485034 106702 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 719 17 1 9 7.1 CCCc1nc(CC)c(C(=O)CCN(C(=O)CC)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL316503 106702 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 719 17 1 9 7.1 CCCc1nc(CC)c(C(=O)CCN(C(=O)CC)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
15292113 95587 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 95587 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10462598 113637 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 113637 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10259447 16747 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 16747 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL938 214130 24 None -1 2 Human 9.3 pIC50 = 9.3 Binding
Inhibition of human angiotensin II AT2 receptorInhibition of human angiotensin II AT2 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.bmc.2010.07.034
10462933 16702 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 16702 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462598 113637 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 113637 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10009984 112681 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 112681 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
15292112 102475 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 102475 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44314780 102604 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 102604 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10101690 116361 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 116361 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
8374 2877 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
9937291 2877 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
CHEMBL34124 2877 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
DB16266 2877 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
10327309 113392 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 113392 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
10372451 116791 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 116791 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
8374 2877 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
9937291 2877 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
CHEMBL34124 2877 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
DB16266 2877 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
44338834 7776 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL108981 7776 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44338834 7776 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL108981 7776 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44303887 201630 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64861 201630 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
8374 2877 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
9937291 2877 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
CHEMBL34124 2877 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
DB16266 2877 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
44315344 104602 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 104602 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
16133225 415 47 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
172198 415 47 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
2504 415 47 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
45266664 415 47 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
5272 415 47 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
CHEMBL408403 415 47 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
DB11842 415 47 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
11765454 117565 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 117565 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10349897 113929 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 113929 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315058 70110 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 70110 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315059 203006 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 203006 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10101606 15595 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 15595 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL385283 210600 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
19430475 202549 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 787 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71125 202549 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 787 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F 10.1016/S0960-894X(00)80077-3
9940350 203050 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
CHEMBL74573 203050 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
9851889 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL302102 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
9940350 203050 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74573 203050 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
10031067 99888 3 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
CHEMBL289614 99888 3 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
10031067 99888 3 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL289614 99888 3 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
10031067 99888 3 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL289614 99888 3 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
44283174 99612 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 7.2 CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL287250 99612 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 7.2 CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
9851889 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)80595-3
CHEMBL302102 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)80595-3
9851889 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81115-X
CHEMBL302102 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81115-X
9851889 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00019a004
CHEMBL302102 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00019a004
10395076 168011 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168011 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315058 70110 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 70110 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
9851889 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL302102 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44303886 100413 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL293660 100413 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
9851889 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
CHEMBL302102 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
9851889 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm9504722
CHEMBL302102 101604 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm9504722
9851889 101604 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm058225d
CHEMBL302102 101604 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm058225d
44315057 203121 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 203121 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10078475 112831 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 112831 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44283175 119864 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 8 1 7 7.1 Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL35324 119864 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 8 1 7 7.1 Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44315304 203301 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 203301 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
44314823 161338 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 161338 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
9874508 202974 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 202974 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10439819 169322 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 169322 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44338697 109171 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 613 11 1 8 6.8 CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL322471 109171 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 613 11 1 8 6.8 CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
10372550 163964 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 163964 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
15292112 102475 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 102475 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44314780 102604 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 102604 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10462573 116508 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 116508 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL414533 211388 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
10259265 109554 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 109554 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10327309 113392 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 113392 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
10439837 16177 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 16177 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
9892451 48476 17 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155836 48476 17 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
10010164 116894 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 116894 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10032988 116417 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116417 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765454 117565 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 117565 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10100951 114546 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 114546 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
20647138 100006 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL290829 100006 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
9918412 202559 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 16 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL71172 202559 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 16 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
19430479 202566 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71220 202566 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
10462053 167494 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 664 15 4 8 5.9 CCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL432378 167494 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 664 15 4 8 5.9 CCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10327728 97671 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 97671 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315282 96176 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 96176 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
9917399 101676 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL302519 101676 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
9917399 101676 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1021/jm9504722
CHEMBL302519 101676 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1021/jm9504722
44315349 60071 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 60071 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44311675 101684 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL302579 101684 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311676 102587 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL307318 102587 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311412 104850 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 17 1 9 7.1 CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL311625 104850 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 17 1 9 7.1 CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311072 202485 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70789 202485 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311736 202506 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70867 202506 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311452 202800 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 15 1 9 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL72595 202800 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 15 1 9 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
15780095 98143 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 595 9 1 7 6.5 CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL276853 98143 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 595 9 1 7 6.5 CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
15780091 120483 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 618 9 1 8 6.1 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL35638 120483 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 618 9 1 8 6.1 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
9851082 100551 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(01)80554-0
CHEMBL294512 100551 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(01)80554-0
9810305 98120 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL276674 98120 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
9810305 98120 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL276674 98120 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
1037 1548 65 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
3940 1548 65 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
5281037 1548 65 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
588 1548 65 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
CHEMBL813 1548 65 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
DB00876 1548 65 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
9810305 98120 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 98120 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
44315144 96144 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 96144 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
9851082 100551 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
CHEMBL294512 100551 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
10395395 106810 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL317159 106810 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10033013 111162 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 750 17 1 10 7.3 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm00015a016
CHEMBL328602 111162 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 750 17 1 10 7.3 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm00015a016
9937227 200486 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
CHEMBL60942 200486 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
10078661 206506 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 17 1 9 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)C(C)C)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL98746 206506 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 17 1 9 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)C(C)C)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10259277 206573 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 715 18 1 9 7.4 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1)c1cccnc1 10.1021/jm00015a016
CHEMBL99112 206573 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 715 18 1 9 7.4 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1)c1cccnc1 10.1021/jm00015a016
44315304 203301 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 203301 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315057 203121 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 203121 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44322202 106388 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 692 17 4 8 6.7 CCCCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL314506 106388 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 692 17 4 8 6.7 CCCCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44322203 106451 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 650 13 4 8 5.4 CCCc1nc(SC)c(C(O)(C(=O)O)C(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL314827 106451 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 650 13 4 8 5.4 CCCc1nc(SC)c(C(O)(C(=O)O)C(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44321791 204887 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 698 14 4 8 6.0 CCCc1nc(SC)c(C(O)(Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89053 204887 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 698 14 4 8 6.0 CCCc1nc(SC)c(C(O)(Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10078554 116467 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 116467 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765560 15362 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 15362 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10417321 15442 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 15442 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
9810305 98120 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 98120 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
10485116 116353 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
CHEMBL338101 116353 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
18965174 100401 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 507 12 1 3 5.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL293625 100401 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 507 12 1 3 5.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
9870559 46605 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 8 1 4 5.6 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)C1CCCC1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL154057 46605 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 8 1 4 5.6 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)C1CCCC1)C2 10.1016/S0960-894X(01)81122-7
19939495 206090 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory concentration against AT2 receptor from rat adrenal tissues.Inhibitory concentration against AT2 receptor from rat adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 206090 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory concentration against AT2 receptor from rat adrenal tissues.Inhibitory concentration against AT2 receptor from rat adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10010071 116846 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 116846 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL216061 207571 10 None - 2 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00108a043
10395335 116581 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 116581 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10349897 113929 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 113929 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439858 16682 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 16682 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315060 102583 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 102583 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL938 214130 24 None -1 2 Human 8.9 pIC50 = 8.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm00065a013
15780089 99348 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 603 8 1 7 6.4 Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL285432 99348 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 603 8 1 7 6.4 Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10349732 118248 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL341828 118248 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
10101351 168099 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 168099 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259489 16737 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
CHEMBL125231 16737 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
22850669 201297 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL63109 201297 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10321941 137619 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 458 10 2 5 5.4 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl 10.1021/jm00108a043
CHEMBL37679 137619 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 458 10 2 5 5.4 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl 10.1021/jm00108a043
20647138 100006 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
CHEMBL290829 100006 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
10033136 15897 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 15897 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10394859 17247 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 17247 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
20647138 100006 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL290829 100006 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
19430442 202474 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL70726 202474 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
10078663 206052 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
CHEMBL96075 206052 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
10100951 114546 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL334300 114546 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
10078663 206052 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL96075 206052 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
44381553 119830 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 13 2 8 6.8 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352947 119830 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 13 2 8 6.8 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10100951 114546 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 114546 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
44315350 104739 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 104739 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10417321 15442 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 15442 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44348523 112680 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 112680 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
9870914 201636 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64881 201636 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44299731 416 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
585 416 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
CHEMBL56448 416 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
10395076 168011 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168011 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315059 203006 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 203006 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19430462 102511 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306638 102511 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(00)80077-3
44321824 203852 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 642 13 4 8 5.5 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL81236 203852 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 642 13 4 8 5.5 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
22402434 48762 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 1 5 5.8 COc1ccc(COc2c(OC)ccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81122-7
CHEMBL156100 48762 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 1 5 5.8 COc1ccc(COc2c(OC)ccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81122-7
44311617 102066 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 13 1 9 6.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL304065 102066 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 13 1 9 6.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 10.1016/S0960-894X(00)80077-3
44311538 102490 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 699 14 1 10 6.9 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL306435 102490 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 699 14 1 10 6.9 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311755 102659 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 18 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL307866 102659 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 18 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311071 102940 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 8.0 CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL308482 102940 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 8.0 CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 10.1016/S0960-894X(00)80077-3
44311752 104386 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL311018 104386 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 10.1016/S0960-894X(00)80077-3
10005139 57299 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC(C(=O)O)=C2 10.1016/j.bmc.2010.10.043
CHEMBL1668008 57299 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC(C(=O)O)=C2 10.1016/j.bmc.2010.10.043
14403498 100562 3 None - 0 Rat 8.0 pIC50 = 8 Binding
Binding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomesBinding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomes
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
CHEMBL294558 100562 3 None - 0 Rat 8.0 pIC50 = 8 Binding
Binding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomesBinding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomes
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
44303640 198429 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 511 12 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL59611 198429 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 511 12 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)cc1 10.1016/S0960-894X(01)80554-0
44303208 200859 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 555 12 1 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(C)c1 10.1016/S0960-894X(01)80554-0
CHEMBL61168 200859 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 555 12 1 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(C)c1 10.1016/S0960-894X(01)80554-0
44210590 58406 0 None - 0 Rat 8.0 pIC50 = 8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 605 11 3 8 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168490 58406 0 None - 0 Rat 8.0 pIC50 = 8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 605 11 3 8 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10078475 112831 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 112831 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
18965184 201227 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 504 4 0 2 7.3 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)C(C)CN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL62806 201227 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 504 4 0 2 7.3 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)C(C)CN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
44330905 4344 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 746 19 1 8 8.2 CCCCN(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)C(=O)c1ccccc1 10.1021/jm00015a016
CHEMBL101455 4344 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 746 19 1 8 8.2 CCCCN(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)C(=O)c1ccccc1 10.1021/jm00015a016
9937227 200486 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
CHEMBL60942 200486 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
11755896 116471 0 None - 0 Rat 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 505 7 1 3 5.8 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
CHEMBL338709 116471 0 None - 0 Rat 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 505 7 1 3 5.8 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
11765541 118503 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342605 118503 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9988057 105681 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 831 10 5 15 3.3 CC(=O)O[C@@H]1C2=C(C)[C@@H](OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)[C@H]1O)C2(C)C 10.1016/0960-894X(95)00477-B
CHEMBL313691 105681 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 831 10 5 15 3.3 CC(=O)O[C@@H]1C2=C(C)[C@@H](OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)[C@H]1O)C2(C)C 10.1016/0960-894X(95)00477-B
44311496 202542 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 722 15 2 8 7.2 CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL71069 202542 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 722 15 2 8 7.2 CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1016/S0960-894X(00)80076-1
44379292 119828 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 613 12 1 6 7.4 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352934 119828 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 613 12 1 6 7.4 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81125-2
10077497 11264 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
CHEMBL1179757 11264 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
CHEMBL98426 11264 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
44328276 112230 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 10 1 7 6.5 C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL330464 112230 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 10 1 7 6.5 C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10077929 205614 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 643 14 2 8 5.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1021/jm00043a020
CHEMBL93606 205614 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 643 14 2 8 5.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1021/jm00043a020
15818748 99451 0 None - 0 Human 7.0 pIC50 = 7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 543 9 1 5 5.7 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL286134 99451 0 None - 0 Human 7.0 pIC50 = 7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 543 9 1 5 5.7 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311571 202750 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL72249 202750 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44303248 201065 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 414 8 1 6 4.4 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1C 10.1016/S0960-894X(01)80554-0
CHEMBL61976 201065 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 414 8 1 6 4.4 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1C 10.1016/S0960-894X(01)80554-0
44311567 102539 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 11 2 8 6.4 CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306922 102539 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 11 2 8 6.4 CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311450 103624 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 652 12 2 8 6.4 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309365 103624 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 652 12 2 8 6.4 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311497 167294 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 547 10 1 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL430997 167294 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 547 10 1 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311664 202462 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 680 12 2 8 5.9 CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70638 202462 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 680 12 2 8 5.9 CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44377125 55350 0 None - 0 Rat 6.0 pIC50 = 6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 545 10 1 7 5.0 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL162148 55350 0 None - 0 Rat 6.0 pIC50 = 6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 545 10 1 7 5.0 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
1610 2315 89 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
3941 2315 89 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
3961 2315 89 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
590 2315 89 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
CHEMBL191 2315 89 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
DB00678 2315 89 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
44376747 119584 0 None - 0 Rat 5.0 pIC50 = 5 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 510 11 2 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350851 119584 0 None - 0 Rat 5.0 pIC50 = 5 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 510 11 2 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
9852384 99950 3 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL290214 99950 3 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
9852384 99950 3 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm049715t
CHEMBL290214 99950 3 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm049715t
9852384 99950 3 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
CHEMBL290214 99950 3 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
23583071 187635 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1450 7 8 31 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)N4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL499234 187635 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1450 7 8 31 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)N4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
164613196 184857 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 951 23 12 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4861538 184857 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 951 23 12 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
10440203 118482 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342492 118482 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44315058 70110 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 70110 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315344 104602 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 104602 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10258694 112092 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 10.1021/jm00043a020
CHEMBL330165 112092 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 10.1021/jm00043a020
10233073 205899 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 10.1021/jm00043a020
CHEMBL95198 205899 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 10.1021/jm00043a020
10438523 206403 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 10 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
CHEMBL98126 206403 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 10 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
57380412 70184 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947129 70184 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
15296724 119513 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 462 7 2 5 4.3 COc1ccc(NC(=O)N2Cc3ccc(OC)c(OCc4ccccc4)c3CC2C(=O)O)cc1 10.1016/S0960-894X(01)81122-7
CHEMBL350220 119513 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 462 7 2 5 4.3 COc1ccc(NC(=O)N2Cc3ccc(OC)c(OCc4ccccc4)c3CC2C(=O)O)cc1 10.1016/S0960-894X(01)81122-7
11757357 206253 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 552 9 1 6 5.8 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL97273 206253 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 552 9 1 6 5.8 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
23584461 178097 1 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1368 7 9 30 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL467872 178097 1 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1368 7 9 30 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
90663955 106293 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL 1280 38 16 17 0.0 CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)C(N)[C@H](CC(C)C)C(C)=O 10.1021/jm00065a013
CHEMBL3144487 106293 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL 1280 38 16 17 0.0 CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)C(N)[C@H](CC(C)C)C(C)=O 10.1021/jm00065a013
164625885 185684 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4873899 185684 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
44303458 167319 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(Cl)c1 10.1016/S0960-894X(01)80554-0
CHEMBL431137 167319 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(Cl)c1 10.1016/S0960-894X(01)80554-0
10417251 96457 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL265797 96457 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
19939453 111898 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL329679 111898 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10417251 96457 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL265797 96457 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL413925 211354 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS2 10.1021/jm00065a013
44381724 119802 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352771 119802 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
10259265 109554 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 109554 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
44315180 102423 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 102423 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44373238 96640 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 1051 29 11 12 1.9 CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O 10.1021/jm9504722
CHEMBL267354 96640 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 1051 29 11 12 1.9 CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O 10.1021/jm9504722
44304147 100309 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 0 4 5.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 10.1016/S0960-894X(01)81007-6
CHEMBL292939 100309 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 0 4 5.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 10.1016/S0960-894X(01)81007-6
44315057 203121 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 203121 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44322236 112330 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 14 4 8 5.4 CCCCc1nc(SC)c(C(O)CC(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL330744 112330 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 14 4 8 5.4 CCCCc1nc(SC)c(C(O)CC(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44323447 106418 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 627 11 1 9 6.5 CCCCc1nc2ccn(C(C(=O)OC3CCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL314605 106418 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 627 11 1 9 6.5 CCCCc1nc2ccn(C(C(=O)OC3CCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44379269 56873 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 644 12 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164769 56873 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 644 12 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
10438745 106732 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 10.1021/jm00043a020
CHEMBL316655 106732 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 10.1021/jm00043a020
10349597 111128 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 680 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 10.1021/jm00043a020
CHEMBL328434 111128 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 680 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 10.1021/jm00043a020
10416475 205970 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 10.1021/jm00043a020
CHEMBL95579 205970 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 10.1021/jm00043a020
44300735 100293 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 629 9 1 9 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL292829 100293 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 629 9 1 9 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
46910582 70010 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945009 70010 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
19385652 47254 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 459 9 1 6 5.3 CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15458 47254 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 459 9 1 6 5.3 CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
19385680 98424 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 487 10 1 6 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC 10.1016/0960-894X(95)00185-V
CHEMBL279103 98424 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 487 10 1 6 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC 10.1016/0960-894X(95)00185-V
15696755 147491 1 None - 0 Rat 4.9 pIC50 = 4.9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 306 7 1 3 3.6 CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL39345 147491 1 None - 0 Rat 4.9 pIC50 = 4.9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 306 7 1 3 3.6 CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
44323530 205451 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 586 10 1 8 5.1 CCCCc1nc2ccn(C(C(=O)N(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL92479 205451 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 586 10 1 8 5.1 CCCCc1nc2ccn(C(C(=O)N(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10259395 26789 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL136465 26789 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44381552 119781 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 649 13 3 9 5.0 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352629 119781 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 649 13 3 9 5.0 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 10.1016/S0960-894X(01)81126-4
10349659 111055 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 688 10 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 10.1021/jm00043a020
CHEMBL327988 111055 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 688 10 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 10.1021/jm00043a020
10439275 167497 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 10.1021/jm00043a020
CHEMBL432392 167497 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 10.1021/jm00043a020
10054753 206405 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 629 9 2 7 5.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL98140 206405 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 629 9 2 7 5.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
44300615 195108 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 572 9 1 7 6.5 CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL56549 195108 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 572 9 1 7 6.5 CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
44373417 52104 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 10.1021/jm9504722
CHEMBL159004 52104 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 10.1021/jm9504722
57380649 70032 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 549 10 2 4 6.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945149 70032 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 549 10 2 4 6.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
11765394 118272 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 14 2 8 7.3 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C 10.1021/jm00052a006
CHEMBL341986 118272 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 14 2 8 7.3 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C 10.1021/jm00052a006
19939409 106676 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 710 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL316299 106676 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 710 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
136026557 205135 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 617 11 1 10 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL90663 205135 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 617 11 1 10 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00477-B
44309903 202689 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL71925 202689 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
19939495 206090 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 206090 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
44309903 202689 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL71925 202689 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
44270330 51469 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 10 1 5 6.2 CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15847 51469 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 10 1 5 6.2 CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
57380647 70011 0 None - 1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945010 70011 0 None - 1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
10349791 111091 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 10.1021/jm00043a020
CHEMBL328176 111091 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 10.1021/jm00043a020
10008962 118768 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 615 10 2 8 5.4 CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343719 118768 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 615 10 2 8 5.4 CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
73347893 92194 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435828 92194 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
10484866 31569 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 699 14 2 8 7.0 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL140619 31569 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 699 14 2 8 7.0 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
44322097 106622 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 608 12 4 8 4.6 CCCc1nc(SC)c(C(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL315994 106622 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 608 12 4 8 4.6 CCCc1nc(SC)c(C(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381425 119948 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 681 12 3 8 7.2 CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353980 119948 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 681 12 3 8 7.2 CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
18965154 100134 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 490 4 0 2 6.9 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL291818 100134 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 490 4 0 2 6.9 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
44303880 201284 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 12 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CCO)C1 10.1016/S0960-894X(01)81007-6
CHEMBL63046 201284 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 12 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CCO)C1 10.1016/S0960-894X(01)81007-6
44304044 201496 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 7 1 3 4.3 CCCCCN(C)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64280 201496 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 7 1 3 4.3 CCCCCN(C)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44323293 106550 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 629 14 1 9 6.8 CCCCCOC(=O)C(c1ccccc1)n1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1=O 10.1016/0960-894X(95)00477-B
CHEMBL315483 106550 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 629 14 1 9 6.8 CCCCCOC(=O)C(c1ccccc1)n1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1=O 10.1016/0960-894X(95)00477-B
44323357 111894 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 648 11 1 8 6.7 CCCCc1nc2ccn(C(C(=O)N(C)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL329655 111894 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 648 11 1 8 6.7 CCCCc1nc2ccn(C(C(=O)N(C)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323352 204824 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 9 1 9 5.2 CCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL88663 204824 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 9 1 9 5.2 CCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10326775 111747 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 10.1021/jm00043a020
CHEMBL329089 111747 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 10.1021/jm00043a020
10483726 205842 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00043a020
CHEMBL94910 205842 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00043a020
10349506 206319 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 10.1021/jm00043a020
CHEMBL97615 206319 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 10.1021/jm00043a020
44300637 100458 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 600 11 1 7 7.2 CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL293949 100458 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 600 11 1 7 7.2 CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
10100413 196913 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 620 9 1 7 7.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL57853 196913 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 620 9 1 7 7.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
15296725 164733 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 535 9 0 5 5.9 CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL423236 164733 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 535 9 0 5 5.9 CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
46910583 70009 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 561 11 2 5 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945008 70009 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 561 11 2 5 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
44379348 164369 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 558 10 1 7 4.7 CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL422374 164369 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 558 10 1 7 4.7 CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
10439172 205750 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 644 13 2 8 5.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 10.1021/jm00043a020
CHEMBL94355 205750 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 644 13 2 8 5.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 10.1021/jm00043a020
44377171 119706 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 485 6 1 8 5.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 10.1016/S0960-894X(01)80193-1
CHEMBL352042 119706 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 485 6 1 8 5.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 10.1016/S0960-894X(01)80193-1
15287894 54662 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(95)00185-V
CHEMBL16148 54662 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(95)00185-V
44381739 58477 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168771 58477 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
44381739 58477 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL168771 58477 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
10326797 205840 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 10.1021/jm00043a020
CHEMBL94905 205840 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 10.1021/jm00043a020
10326460 206367 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 614 9 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL97897 206367 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 614 9 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 10.1021/jm00043a020
44327912 206394 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 748 12 1 9 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC 10.1021/jm00043a020
CHEMBL98068 206394 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 748 12 1 9 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC 10.1021/jm00043a020
44348153 117467 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 10.1021/jm00075a033
CHEMBL340367 117467 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 10.1021/jm00075a033
44210836 56215 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 453 6 1 8 3.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 10.1016/S0960-894X(01)80193-1
CHEMBL163523 56215 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 453 6 1 8 3.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 10.1016/S0960-894X(01)80193-1
73357017 92197 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 483 10 2 4 6.2 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
CHEMBL2435831 92197 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 483 10 2 4 6.2 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
44323532 205405 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccc(Cl)cc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL92206 205405 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccc(Cl)cc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
9830680 100176 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL292150 100176 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
9830680 100176 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL292150 100176 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
10372497 118241 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341783 118241 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9830680 100176 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL292150 100176 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00043a020
10078800 108704 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 108704 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
9830680 100176 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm9504722
CHEMBL292150 100176 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm9504722
19754050 202182 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 603 15 2 7 6.6 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68786 202182 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 603 15 2 7 6.6 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 10.1016/S0960-894X(01)81115-X
44381528 58684 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 548 10 2 8 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169009 58684 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 548 10 2 8 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10394995 110906 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 10.1021/jm00043a020
CHEMBL327191 110906 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 10.1021/jm00043a020
10077743 206218 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1021/jm00043a020
CHEMBL97068 206218 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1021/jm00043a020
44304148 201598 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 458 4 1 3 4.3 CN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL64714 201598 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 458 4 1 3 4.3 CN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)c1ccccc1 10.1016/S0960-894X(01)81007-6
22402428 48487 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 450 6 2 4 4.5 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Nc1ccc(F)cc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155847 48487 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 450 6 2 4 4.5 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Nc1ccc(F)cc1)C2 10.1016/S0960-894X(01)81122-7
15229605 47890 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 463 7 1 5 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL15517 47890 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 463 7 1 5 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 10.1016/0960-894X(95)00185-V
44323448 96402 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 559 10 2 8 5.1 CCCCc1nc2ccn(C(C(=O)O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL265291 96402 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 559 10 2 8 5.1 CCCCc1nc2ccn(C(C(=O)O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
11764788 100391 0 None - 1 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL293501 100391 0 None - 1 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9810305 98120 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 98120 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
9895212 119135 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL346728 119135 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
44385182 60748 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 637 10 3 7 5.7 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL176473 60748 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 637 10 3 7 5.7 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
10031920 107501 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 10.1021/jm00043a020
CHEMBL319404 107501 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 10.1021/jm00043a020
44372814 119285 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 672 11 2 6 6.7 CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1021/jm9504722
CHEMBL348157 119285 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 672 11 2 6 6.7 CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1021/jm9504722
44303888 201588 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 552 12 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64674 201588 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 552 12 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10390872 115646 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 7 1 6 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00050a002
CHEMBL335778 115646 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 7 1 6 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00050a002
44377086 119446 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 546 11 2 7 4.8 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349652 119446 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 546 11 2 7 4.8 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
10101582 118871 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 15 2 8 7.4 CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 10.1021/jm00052a006
CHEMBL344466 118871 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 15 2 8 7.4 CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 10.1021/jm00052a006
5311348 100206 3 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1016/S0960-894X(01)81007-6
CHEMBL292277 100206 3 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1016/S0960-894X(01)81007-6
10484986 118192 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 11 1 9 6.8 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341715 118192 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 11 1 9 6.8 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
1952 2179 3 None - 2 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
5312129 2179 3 None - 2 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
CHEMBL1182768 2179 3 None - 2 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
9960852 106698 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 12 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL316482 106698 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 12 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10416957 111011 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 10.1021/jm00043a020
CHEMBL327791 111011 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 10.1021/jm00043a020
10010125 206291 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97464 206291 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 10.1021/jm00043a020
136059719 188540 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1438 10 9 31 4.5 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL510526 188540 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1438 10 9 31 4.5 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
44300827 101297 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 602 8 1 7 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL299897 101297 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 602 8 1 7 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
44348355 112888 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 10.1021/jm00075a033
CHEMBL331797 112888 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 10.1021/jm00075a033
44311289 101755 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.7 CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL302964 101755 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.7 CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311455 102271 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305017 102271 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311754 102523 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 757 16 1 9 9.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL306761 102523 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 757 16 1 9 9.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311715 102721 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 741 17 1 10 6.7 CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL308323 102721 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 741 17 1 10 6.7 CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311435 202324 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL69721 202324 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311434 202424 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70370 202424 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311414 202522 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70935 202522 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311413 202648 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 709 17 1 9 8.1 CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71639 202648 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 709 17 1 9 8.1 CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311753 202905 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 773 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL73283 202905 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 773 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
3936 2180 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
6603900 2180 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
CHEMBL288174 2180 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
44303191 167323 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 529 12 1 7 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(F)c1 10.1016/S0960-894X(01)80554-0
CHEMBL431162 167323 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 529 12 1 7 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(F)c1 10.1016/S0960-894X(01)80554-0
3936 2180 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
6603900 2180 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
CHEMBL288174 2180 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
3936 2180 28 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrsDisplacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2010.03.064
6603900 2180 28 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrsDisplacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2010.03.064
CHEMBL288174 2180 28 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrsDisplacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2010.03.064
44322095 106527 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCc1nc(SC)c(C(O)(CC)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL315327 106527 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCc1nc(SC)c(C(O)(CC)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10259841 15982 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 15982 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10259447 16747 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 16747 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
11765177 116507 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 116507 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
3936 2180 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
6603900 2180 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
CHEMBL288174 2180 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
44372744 51872 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 451 7 1 6 5.5 CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 10.1021/jm9504722
CHEMBL158795 51872 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 451 7 1 6 5.5 CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 10.1021/jm9504722
3936 2180 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesInhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
6603900 2180 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesInhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
CHEMBL288174 2180 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesInhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
19430458 202375 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 769 16 1 9 8.4 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL70100 202375 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 769 16 1 9 8.4 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 10.1016/S0960-894X(00)80077-3
10010234 97975 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL275552 97975 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10078320 204789 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 684 13 4 8 5.8 CCCc1nc(SC)c(C(O)(C(=O)O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL88446 204789 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 684 13 4 8 5.8 CCCc1nc(SC)c(C(O)(C(=O)O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381426 119766 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 666 12 2 8 6.8 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352502 119766 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 666 12 2 8 6.8 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10349897 113929 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 113929 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259489 16737 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
CHEMBL125231 16737 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
10078780 116416 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 116416 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259468 117977 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 117977 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44309938 202597 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 619 14 2 8 6.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL71388 202597 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 619 14 2 8 6.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
19802473 197028 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 415 5 1 7 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL58156 197028 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 415 5 1 7 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10439862 118267 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341934 118267 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10010195 118679 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343142 118679 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10032851 16656 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16656 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10485116 116353 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL338101 116353 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
9895984 203041 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL74476 203041 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10485116 116353 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
CHEMBL338101 116353 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
10372810 105721 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL313868 105721 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
44315180 102423 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 102423 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9895984 203041 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
CHEMBL74476 203041 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
9892451 48476 17 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155836 48476 17 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
9895984 203041 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1021/jm9504722
CHEMBL74476 203041 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1021/jm9504722
10101284 205669 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL93907 205669 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
10101284 205669 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL93907 205669 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
16133225 415 47 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
172198 415 47 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
2504 415 47 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
45266664 415 47 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
5272 415 47 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
CHEMBL408403 415 47 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
DB11842 415 47 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
11765560 15362 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 15362 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10010071 116846 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 116846 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10101284 205669 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
CHEMBL93907 205669 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
44315060 102583 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 102583 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
10032877 15374 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 15374 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10462683 112783 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 112783 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10417195 108592 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321313 108592 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
44310069 202043 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 617 16 2 7 7.0 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67801 202043 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 617 16 2 7 7.0 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10009984 112681 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 112681 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
44303884 201145 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62422 201145 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44381403 58854 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 11 2 9 5.4 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169968 58854 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 11 2 9 5.4 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10259657 118888 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344597 118888 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44381413 120210 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 14 3 8 6.6 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354779 120210 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 14 3 8 6.6 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
9987414 116548 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 116548 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44311453 202339 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 678 17 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL69839 202339 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 678 17 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311557 202580 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL71286 202580 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311558 203015 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74236 203015 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44303388 162357 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 539 12 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(C)c1 10.1016/S0960-894X(01)80554-0
CHEMBL417393 162357 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 539 12 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(C)c1 10.1016/S0960-894X(01)80554-0
44303459 198603 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 586 13 1 10 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)80554-0
CHEMBL59728 198603 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 586 13 1 10 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)80554-0
44303197 200550 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 619 12 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Br)c1 10.1016/S0960-894X(01)80554-0
CHEMBL60992 200550 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 619 12 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Br)c1 10.1016/S0960-894X(01)80554-0
10394727 102588 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 672 15 2 9 5.4 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL307321 102588 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 672 15 2 9 5.4 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
44210589 58288 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 11 3 8 5.4 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168413 58288 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 11 3 8 5.4 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
11765454 117565 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 117565 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10092454 99783 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II induced contractions in rabbit aortic ringsInhibition of Angiotensin II induced contractions in rabbit aortic rings
ChEMBL 401 7 2 5 4.9 CCCCc1nc2ccnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00037a014
CHEMBL288705 99783 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II induced contractions in rabbit aortic ringsInhibition of Angiotensin II induced contractions in rabbit aortic rings
ChEMBL 401 7 2 5 4.9 CCCCc1nc2ccnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00037a014
44303859 199306 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 514 8 1 3 5.8 CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL60209 199306 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 514 8 1 3 5.8 CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 10.1016/S0960-894X(01)81007-6
9896877 59916 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 748 6 1 8 8.3 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
CHEMBL174080 59916 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 748 6 1 8 8.3 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
44311584 102307 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 695 16 1 8 8.1 CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL305239 102307 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 695 16 1 8 8.1 CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80077-3
44311406 103330 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL309081 103330 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10480819 21606 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 492 6 1 3 6.1 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL131940 21606 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 492 6 1 3 6.1 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
44311635 101754 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 581 10 2 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(00)80076-1
CHEMBL302959 101754 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 581 10 2 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(00)80076-1
44311499 202694 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 557 17 2 7 6.6 CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
CHEMBL71953 202694 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 557 17 2 7 6.6 CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
44384389 129315 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 572 2 2 7 5.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 10.1016/0960-894X(96)00116-3
CHEMBL367569 129315 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 572 2 2 7 5.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 10.1016/0960-894X(96)00116-3
10429298 18714 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL128416 18714 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
44210864 147573 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 503 8 1 5 4.8 CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL39352 147573 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 503 8 1 5 4.8 CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
9850811 154202 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 561 8 1 6 5.3 CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL39996 154202 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 561 8 1 6 5.3 CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311616 101670 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL302485 101670 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311776 102541 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306924 102541 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10255071 162912 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 0 4 5.6 COC(=O)C1Cc2c(cccc2-c2ccc(OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL419974 162912 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 0 4 5.6 COC(=O)C1Cc2c(cccc2-c2ccc(OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
9981762 162914 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 5 0 3 5.6 COC(=O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL419979 162914 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 5 0 3 5.6 COC(=O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44379347 119981 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 544 9 1 7 4.3 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL354338 119981 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 544 9 1 7 4.3 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44377075 119472 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 479 10 1 6 4.1 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349869 119472 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 479 10 1 6 4.1 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
15287882 49474 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 414 9 1 4 5.6 CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15670 49474 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 414 9 1 4 5.6 CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
22407453 49489 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15671 49489 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
9987311 116257 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 706 12 1 9 6.7 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL337588 116257 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 706 12 1 9 6.7 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
14952914 154371 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 410 9 2 5 5.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(O)c(C)c1 10.1021/jm00108a043
CHEMBL40089 154371 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 410 9 2 5 5.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(O)c(C)c1 10.1021/jm00108a043
44338666 110469 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 9 1 8 5.5 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL326217 110469 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 9 1 8 5.5 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44379335 119716 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 574 10 2 6 6.0 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352137 119716 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 574 10 2 6 6.0 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1016/S0960-894X(01)81125-2
44379293 119784 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 611 10 1 6 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352639 119784 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 611 10 1 6 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1016/S0960-894X(01)81125-2
44376780 56210 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 509 10 1 7 4.1 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL163486 56210 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 509 10 1 7 4.1 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
44300734 101336 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 586 9 1 7 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL300154 101336 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 586 9 1 7 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
10049400 154901 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(94)00476-V
CHEMBL40381 154901 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(94)00476-V
44323358 112013 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 626 10 1 8 6.0 CCCCc1nc2ccn(C(C(=O)N3CCCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL329887 112013 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 626 10 1 8 6.0 CCCCc1nc2ccn(C(C(=O)N3CCCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
19939398 106850 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 10.1021/jm00043a020
CHEMBL317547 106850 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 10.1021/jm00043a020
10055534 156919 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL407919 156919 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 10.1021/jm00043a020
44338833 9089 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 537 9 2 8 5.4 CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL110265 9089 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 537 9 2 8 5.4 CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
15231091 93554 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL24861 93554 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
15231091 93554 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL24861 93554 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL443325 212173 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSSC[C@H](C(=O)N[C@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C[C@H](CN1C(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC)SS2 10.1021/jm00065a013
44303857 100343 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O 10.1016/S0960-894X(01)81007-6
CHEMBL293195 100343 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O 10.1016/S0960-894X(01)81007-6
10417144 32761 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL141592 32761 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44303852 101879 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 524 11 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL303755 101879 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 524 11 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
18950586 15388 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm00075a033
CHEMBL122017 15388 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm00075a033
44377058 119501 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 554 16 3 6 5.8 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350121 119501 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 554 16 3 6 5.8 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
10482937 166584 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL321086 166584 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL429058 166584 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
14956757 67251 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00052a006
CHEMBL19018 67251 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00052a006
14956757 67251 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00043a020
CHEMBL19018 67251 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00043a020
4189 205195 91 None -38 34 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 205195 91 None -38 34 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 205195 91 None -38 34 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
71455883 83350 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
CHEMBL2205685 83350 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
44372686 96207 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 600 4 2 7 6.2 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O 10.1021/jm9504722
CHEMBL263714 96207 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 600 4 2 7 6.2 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O 10.1021/jm9504722
44211677 130092 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 614 4 2 7 6.6 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
CHEMBL368149 130092 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 614 4 2 7 6.6 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
164623569 185605 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1008 26 12 10 2.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4872735 185605 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1008 26 12 10 2.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
44348302 16314 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm00075a033
CHEMBL123562 16314 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm00075a033
11764826 97832 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 11 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 10.1021/jm00043a020
CHEMBL274710 97832 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 11 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 10.1021/jm00043a020
44348302 16314 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm9504722
CHEMBL123562 16314 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm9504722
10028460 116021 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 488 7 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00050a002
CHEMBL336180 116021 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 488 7 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00050a002
10349512 206267 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 670 11 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97332 206267 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 670 11 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm00043a020
19385665 50788 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 9 1 5 6.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C 10.1016/0960-894X(95)00185-V
CHEMBL15788 50788 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 9 1 5 6.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C 10.1016/0960-894X(95)00185-V
10028815 206355 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 496 8 1 6 4.4 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 10.1021/jm00043a020
CHEMBL97783 206355 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 496 8 1 6 4.4 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 10.1021/jm00043a020
CHEMBL411657 211207 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS[C@H]1C[C@@H](C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)CSS2)N(C(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C1 10.1021/jm00065a013
10078397 12003 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL1184032 12003 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL329290 12003 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
168298448 192102 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 477 5 2 4 5.8 O=c1c(O)c(-c2ccccc2-c2ccc(CNc3cc(C(F)(F)F)cc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
CHEMBL5219534 192102 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 477 5 2 4 5.8 O=c1c(O)c(-c2ccccc2-c2ccc(CNc3cc(C(F)(F)F)cc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
44211576 106634 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 10 1 9 5.2 CCCCc1nc2ccn(C(C(=O)OC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL316063 106634 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 10 1 9 5.2 CCCCc1nc2ccn(C(C(=O)OC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
136059721 188411 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1537 12 10 33 3.3 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL508699 188411 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1537 12 10 33 3.3 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
10429298 18714 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL128416 18714 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44300838 196993 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 530 7 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL57976 196993 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 530 7 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
10009968 112055 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 10.1021/jm00043a020
CHEMBL329942 112055 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 10.1021/jm00043a020
10372341 167635 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 10.1021/jm00043a020
CHEMBL433375 167635 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 10.1021/jm00043a020
16725318 188376 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1494 11 9 32 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL508306 188376 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1494 11 9 32 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
192626 15483 13 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 499 11 1 5 6.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 10.1021/jm00075a033
CHEMBL122212 15483 13 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 499 11 1 5 6.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 10.1021/jm00075a033
9978845 130190 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 408 9 1 3 5.6 CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL36846 130190 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 408 9 1 3 5.6 CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL417584 211487 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
9939191 98489 1 None - 1 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 98489 1 None - 1 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 98489 1 None - 1 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
10326972 111769 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 10.1021/jm00043a020
CHEMBL329099 111769 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 10.1021/jm00043a020
10077555 205677 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 10.1021/jm00043a020
CHEMBL93956 205677 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 10.1021/jm00043a020
19102815 206142 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL96554 206142 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
19385603 98324 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 455 9 1 5 5.6 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL278234 98324 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 455 9 1 5 5.6 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL408885 210989 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSCC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
19754062 102512 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 604 13 3 7 5.9 CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL306641 102512 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 604 13 3 7 5.9 CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10349029 206356 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 10.1021/jm00043a020
CHEMBL97812 206356 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 10.1021/jm00043a020
9888865 57195 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 429 6 1 6 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 10.1016/S0960-894X(01)80193-1
CHEMBL165974 57195 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 429 6 1 6 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 10.1016/S0960-894X(01)80193-1
10055448 30547 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 13 2 8 7.3 CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139582 30547 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 13 2 8 7.3 CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44379334 57804 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 585 10 2 9 4.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167584 57804 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 585 10 2 9 4.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81125-2
44381603 58804 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 532 8 2 7 3.8 CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169798 58804 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 532 8 2 7 3.8 CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/S0960-894X(01)81126-4
133031 100392 16 None - 1 Rat 5.5 pIC50 = 5.5 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00017-0
CHEMBL293511 100392 16 None - 1 Rat 5.5 pIC50 = 5.5 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00017-0
133031 100392 16 None - 1 Rat 5.5 pIC50 = 5.5 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00050a002
CHEMBL293511 100392 16 None - 1 Rat 5.5 pIC50 = 5.5 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00050a002
19385675 51099 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 445 8 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
CHEMBL15816 51099 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 445 8 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
44311537 101862 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 726 15 1 9 8.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL303647 101862 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 726 15 1 9 8.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311580 102306 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305238 102306 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311182 102553 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL307008 102553 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311619 102596 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 756 16 2 8 8.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL307359 102596 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 756 16 2 8 8.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311185 103714 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 733 15 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL309790 103714 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 733 15 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311073 202499 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70843 202499 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311184 202716 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 727 16 1 9 8.6 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL72099 202716 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 727 16 1 9 8.6 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311183 202994 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74069 202994 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311735 203044 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74514 203044 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9937227 200486 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1016/S0960-894X(01)80554-0
CHEMBL60942 200486 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1016/S0960-894X(01)80554-0
9851082 100551 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL294512 100551 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
9987283 161393 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 705 16 1 9 6.7 CCCc1nc(CC)c(C(=O)CCN(C(C)=O)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL415502 161393 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 705 16 1 9 6.7 CCCc1nc(CC)c(C(=O)CCN(C(C)=O)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
133031 100392 16 None - 1 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL293511 100392 16 None - 1 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
9937227 200486 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm9504722
CHEMBL60942 200486 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm9504722
10032820 116801 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 116801 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10372659 117587 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 117587 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315351 104406 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 104406 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
44381402 58853 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 12 2 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169967 58853 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 12 2 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
15780064 99162 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 613 10 1 8 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL284123 99162 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 613 10 1 8 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44381671 119921 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353800 119921 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
15292113 95587 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 95587 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10032858 29548 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
CHEMBL138690 29548 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
9853391 116339 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 116339 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439715 116534 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 116534 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10350123 57298 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 713 12 1 9 6.0 CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F 10.1016/j.bmc.2010.10.043
CHEMBL1668007 57298 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 713 12 1 9 6.0 CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F 10.1016/j.bmc.2010.10.043
19939418 107784 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 13 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL319730 107784 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 13 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
19939495 206090 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 206090 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10395335 116581 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 116581 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
44315144 96144 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 96144 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44381527 58765 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169568 58765 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
44210588 119839 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353037 119839 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10440144 116394 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 116394 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462573 116508 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 116508 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44382947 58921 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 813 19 4 12 6.4 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)CCNc1ccc([N+](=O)[O-])c2nonc12 10.1016/S0960-894X(00)80690-3
CHEMBL170290 58921 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 813 19 4 12 6.4 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)CCNc1ccc([N+](=O)[O-])c2nonc12 10.1016/S0960-894X(00)80690-3
10101608 116528 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 116528 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10372451 116791 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 116791 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10010164 116894 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 116894 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101284 205669 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
CHEMBL93907 205669 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
9850834 154124 13 None - 1 Rat 8.4 pIC50 = 8.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL39959 154124 13 None - 1 Rat 8.4 pIC50 = 8.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
10032988 116417 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116417 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44321825 106626 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL316021 106626 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44309700 102710 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 651 13 2 7 7.2 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL308237 102710 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 651 13 2 7 7.2 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
10433752 18733 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL128527 18733 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44283372 99954 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
CHEMBL290286 99954 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
9875044 206289 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 10.1021/jm00043a020
CHEMBL97446 206289 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 10.1021/jm00043a020
44303835 101296 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)81007-6
CHEMBL299887 101296 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)81007-6
44283372 99954 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm9504722
CHEMBL290286 99954 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm9504722
44311609 102335 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL305369 102335 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311428 102496 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 647 17 1 8 7.1 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306473 102496 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 647 17 1 8 7.1 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311583 202420 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL70353 202420 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
11740800 18649 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 385 4 1 2 4.2 Cc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
CHEMBL128065 18649 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 385 4 1 2 4.2 Cc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
10386376 18748 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 402 4 1 3 4.5 CN(C(=O)N1Cc2ccc(Oc3ccccc3)cc2CC1C(=O)O)c1ccccc1 10.1021/jm00077a001
CHEMBL128594 18748 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 402 4 1 3 4.5 CN(C(=O)N1Cc2ccc(Oc3ccccc3)cc2CC1C(=O)O)c1ccccc1 10.1021/jm00077a001
9939191 98489 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
CHEMBL279629 98489 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
CHEMBL97539 98489 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
44323387 105507 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 600 11 2 8 5.6 CCCCc1nc2ccn(C(C(=O)NC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL313142 105507 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 600 11 2 8 5.6 CCCCc1nc2ccn(C(C(=O)NC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323364 111408 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 599 10 1 8 6.6 CCCCc1nc2ccn(C(C(=O)C(C)(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL328780 111408 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 599 10 1 8 6.6 CCCCc1nc2ccn(C(C(=O)C(C)(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44311758 202965 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 626 12 3 7 6.7 CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL73780 202965 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 626 12 3 7 6.7 CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
9939191 98489 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 98489 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 98489 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
44379350 120272 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 599 10 1 7 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL355443 120272 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 599 10 1 7 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1016/S0960-894X(01)81125-2
9939191 98489 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
CHEMBL279629 98489 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
CHEMBL97539 98489 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
9939191 98489 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL279629 98489 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97539 98489 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10348847 112093 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 615 10 2 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1021/jm00043a020
CHEMBL330170 112093 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 615 10 2 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1021/jm00043a020
10054912 205898 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 10.1021/jm00043a020
CHEMBL95197 205898 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 10.1021/jm00043a020
10054827 163586 0 None - 1 Rat 6.5 pIC50 = 6.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL42101 163586 0 None - 1 Rat 6.5 pIC50 = 6.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
19385729 50606 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15774 50606 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 10.1016/0960-894X(95)00185-V
15818746 123551 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 529 8 1 5 5.3 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL36324 123551 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 529 8 1 5 5.3 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311775 102540 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306923 102540 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44303636 168532 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 418 8 1 6 4.2 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(01)80554-0
CHEMBL439936 168532 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 418 8 1 6 4.2 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(01)80554-0
44311681 102549 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 592 11 2 9 4.8 CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306961 102549 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 592 11 2 9 4.8 CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44384870 59731 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 541 8 2 7 5.5 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL173643 59731 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 541 8 2 7 5.5 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(96)00116-3
44270285 98608 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.7 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL280456 98608 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.7 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
9980304 98084 0 None - 0 Rat 4.5 pIC50 = 4.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 433 9 3 8 1.4 CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 10.1021/jm00053a013
CHEMBL276381 98084 0 None - 0 Rat 4.5 pIC50 = 4.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 433 9 3 8 1.4 CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 10.1021/jm00053a013
10258916 29498 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 11 1 10 6.1 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL138654 29498 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 11 1 10 6.1 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
14952906 100039 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1[N+](=O)[O-] 10.1021/jm00108a043
CHEMBL291086 100039 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1[N+](=O)[O-] 10.1021/jm00108a043
11764788 100391 0 None - 1 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
CHEMBL293501 100391 0 None - 1 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
10439253 111829 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 10.1021/jm00043a020
CHEMBL329255 111829 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 10.1021/jm00043a020
164611280 184416 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4854474 184416 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
10077328 204746 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 601 11 1 9 6.0 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL88170 204746 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 601 11 1 9 6.0 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44315060 102583 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 102583 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
44404967 134895 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
CHEMBL372814 134895 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
44323345 106521 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 557 10 1 8 5.6 CCCCc1nc2ccn(C(C(C)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL315302 106521 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 557 10 1 8 5.6 CCCCc1nc2ccn(C(C(C)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10372723 106834 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL317368 106834 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00043a020
15231094 138767 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 641 12 1 8 7.4 CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL37919 138767 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 641 12 1 8 7.4 CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44309719 202156 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68638 202156 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
44323365 111583 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparationIn vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparation
ChEMBL 619 11 1 8 6.9 CCCCc1nc2ccn(C(C(=O)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL328997 111583 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparationIn vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparation
ChEMBL 619 11 1 8 6.9 CCCCc1nc2ccn(C(C(=O)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44379270 56562 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 580 9 1 7 5.2 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164395 56562 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 580 9 1 7 5.2 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
10010027 206292 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 710 11 1 7 7.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97465 206292 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 710 11 1 7 7.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 10.1021/jm00043a020
130762 97795 9 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00053a013
CHEMBL274447 97795 9 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00053a013
44270306 51898 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15882 51898 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 10.1016/0960-894X(95)00185-V
5311345 2972 39 None 10 2 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm049715t
597 2972 39 None 10 2 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm049715t
CHEMBL321820 2972 39 None 10 2 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm049715t
10394712 118872 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 671 12 2 8 6.2 CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344467 118872 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 671 12 2 8 6.2 CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
122189454 122740 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 497 7 1 5 4.1 COc1ccc(CN2C=NC3CN(C(=O)C(c4ccccc4)c4ccccc4)C(C(=O)O)CC32)cc1C 10.1016/j.bmc.2015.07.045
CHEMBL3613974 122740 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 497 7 1 5 4.1 COc1ccc(CN2C=NC3CN(C(=O)C(c4ccccc4)c4ccccc4)C(C(=O)O)CC32)cc1C 10.1016/j.bmc.2015.07.045
5311345 2972 39 None - 2 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm9504722
597 2972 39 None - 2 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm9504722
CHEMBL321820 2972 39 None - 2 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm9504722
44379217 57841 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 608 10 2 6 7.1 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167929 57841 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 608 10 2 6 7.1 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
15287883 97758 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 8 1 5 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL274260 97758 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 8 1 5 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
10461785 11818 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
CHEMBL1182712 11818 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
CHEMBL262296 11818 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
10032342 206282 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 9 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 10.1021/jm00043a020
CHEMBL97394 206282 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 9 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 10.1021/jm00043a020
44303941 201564 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 580 13 1 5 6.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)OCC)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64575 201564 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 580 13 1 5 6.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)OCC)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
22402431 48835 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 575 8 1 4 6.8 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL156165 48835 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 575 8 1 4 6.8 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2 10.1016/S0960-894X(01)81122-7
44384871 128798 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 726 14 1 7 8.0 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
CHEMBL367095 128798 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 726 14 1 7 8.0 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
18950609 16228 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl 10.1021/jm00075a033
CHEMBL123084 16228 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl 10.1021/jm00075a033
44321626 105486 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 616 14 3 9 4.8 CCCCc1nc(SC)c(C(C)(O)C(=O)OCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL313005 105486 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 616 14 3 9 4.8 CCCCc1nc(SC)c(C(C)(O)C(=O)OCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
9809961 106677 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL316300 106677 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
9809961 106677 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL316300 106677 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9809961 106677 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
CHEMBL316300 106677 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
44323350 106536 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3cccc(Cl)c3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL315400 106536 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3cccc(Cl)c3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
57380414 70186 0 None - 1 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947131 70186 0 None - 1 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
10028545 20805 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 8 1 6 4.9 CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm00050a002
CHEMBL131156 20805 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 8 1 6 4.9 CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm00050a002
10009273 106741 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 10.1021/jm00043a020
CHEMBL316706 106741 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 10.1021/jm00043a020
15236320 172037 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 548 10 1 7 6.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL449095 172037 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 548 10 1 7 6.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
44315059 203006 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 203006 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
2911265 100375 13 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 476 4 0 2 6.5 O=C(N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL293414 100375 13 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 476 4 0 2 6.5 O=C(N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
183134 203136 13 None - 1 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL7550 203136 13 None - 1 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81145-8
9938088 102008 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
CHEMBL304022 102008 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
15230315 54152 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 552 8 0 7 5.7 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc([N+](=O)[O-])cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL160930 54152 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 552 8 0 7 5.7 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc([N+](=O)[O-])cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
14403498 100562 3 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81007-6
CHEMBL294558 100562 3 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81007-6
44322234 204981 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 8 5.1 CCCCc1nc(SC)c(C(=O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89769 204981 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 8 5.1 CCCCc1nc(SC)c(C(=O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
9986299 157905 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 10.1021/jm00043a020
CHEMBL409058 157905 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 10.1021/jm00043a020
44322235 112152 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 7 6.0 CCCCc1nc(SC)c(C(C)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL330302 112152 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 7 6.0 CCCCc1nc(SC)c(C(C)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10032193 118640 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342843 118640 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44211506 57237 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 557 10 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL166338 57237 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 557 10 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44311456 101828 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 792 19 1 10 8.6 CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL303427 101828 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 792 19 1 10 8.6 CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
71611145 184279 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1072 29 14 13 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4852514 184279 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1072 29 14 13 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
44303195 201523 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(F)c1 10.1016/S0960-894X(01)80554-0
CHEMBL64411 201523 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(F)c1 10.1016/S0960-894X(01)80554-0
44331176 206614 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 7.8 CCCc1nc(CC)c(C(=O)CCN(CCC)C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL99438 206614 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 7.8 CCCc1nc(CC)c(C(=O)CCN(CCC)C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10010311 30312 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139325 30312 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10327728 97671 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 97671 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10439819 169322 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 169322 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9850834 154124 13 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
CHEMBL39959 154124 13 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
9850834 154124 13 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL39959 154124 13 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
9850834 154124 13 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL39959 154124 13 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
19102786 205460 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 648 9 1 8 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL92533 205460 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 648 9 1 8 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
44309702 202045 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 591 13 2 8 6.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67805 202045 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 591 13 2 8 6.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10439837 16177 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 16177 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
10462598 113637 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 113637 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10327537 116177 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL337118 116177 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10439848 118705 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343309 118705 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9852499 119957 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 11 3 8 6.1 CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354080 119957 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 11 3 8 6.1 CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 10.1016/S0960-894X(01)81126-4
44314761 102381 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 102381 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
44315350 104739 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 104739 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44304123 198893 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL59913 198893 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44210585 119901 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 14 3 8 6.2 CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81126-4
CHEMBL353615 119901 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 14 3 8 6.2 CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81126-4
10327309 113392 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 113392 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
44322096 97949 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 622 12 4 8 4.8 CCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL275449 97949 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 622 12 4 8 4.8 CCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10259411 30443 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139452 30443 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL408886 210990 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CCSS2 10.1021/jm00065a013
22402420 48797 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 521 9 1 4 5.5 COc1ccc2c(c1OCCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL156129 48797 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 521 9 1 4 5.5 COc1ccc2c(c1OCCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
19939454 205823 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 761 15 2 8 8.2 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
CHEMBL94793 205823 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 761 15 2 8 8.2 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
10003751 18650 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL128066 18650 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
5311348 100206 3 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm00077a001
CHEMBL292277 100206 3 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm00077a001
10455982 116147 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 441 8 1 2 5.6 CCCCCc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
CHEMBL336991 116147 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 441 8 1 2 5.6 CCCCCc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
10435148 117631 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 477 6 1 3 5.5 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL340778 117631 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 477 6 1 3 5.5 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
44303430 100565 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 541 12 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL294578 100565 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 541 12 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)cc1 10.1016/S0960-894X(01)80554-0
44303878 98238 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 5 1 3 4.3 CC(C)N(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)C(C)C 10.1016/S0960-894X(01)81007-6
CHEMBL277567 98238 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 5 1 3 4.3 CC(C)N(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)C(C)C 10.1016/S0960-894X(01)81007-6
22402433 49331 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 2 5 5.2 COc1ccc2c(c1Oc1ccc(N)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL156587 49331 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 2 5 5.2 COc1ccc2c(c1Oc1ccc(N)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
9851082 100551 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL294512 100551 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
44311543 103664 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 643 14 1 8 6.3 CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL309455 103664 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 643 14 1 8 6.3 CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10410436 117301 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 430 5 1 3 4.4 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(C)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL340187 117301 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 430 5 1 3 4.4 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(C)c2ccccc2)C3)cc1 10.1021/jm00077a001
18950592 16611 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 10.1021/jm00075a033
CHEMBL124541 16611 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 10.1021/jm00075a033
44309902 102642 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 598 12 1 7 7.4 CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL307757 102642 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 598 12 1 7 7.4 CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
44311663 202488 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 561 10 2 7 5.8 CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70796 202488 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 561 10 2 7 5.8 CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311569 202998 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 625 13 2 7 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL74113 202998 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 625 13 2 7 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44381714 58809 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 732 11 1 7 7.6 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169827 58809 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 732 11 1 7 7.6 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
10416501 111917 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 9 1 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL329759 111917 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 9 1 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
10349392 206310 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 659 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 10.1021/jm00043a020
CHEMBL97557 206310 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 659 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 10.1021/jm00043a020
44311607 202482 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 517 9 3 8 4.5 CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70770 202482 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 517 9 3 8 4.5 CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44211673 59408 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 678 4 1 8 6.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL172376 59408 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 678 4 1 8 6.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
44300826 197061 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 544 7 1 7 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL58291 197061 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 544 7 1 7 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
10099830 108005 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 584 9 1 7 4.9 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
CHEMBL319955 108005 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 584 9 1 7 4.9 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
44270278 98408 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 443 8 1 5 5.4 CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL278983 98408 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 443 8 1 5 5.4 CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
73349424 92199 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 495 7 1 4 6.3 CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435833 92199 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 495 7 1 4 6.3 CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
44379268 119549 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 666 11 1 8 6.4 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL350554 119549 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 666 11 1 8 6.4 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
10417431 108621 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 718 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 10.1021/jm00043a020
CHEMBL321363 108621 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 718 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 10.1021/jm00043a020
44322967 167379 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 712 15 1 10 7.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccn(C(C(=O)OC(C)C)c4ccccc4)c(=O)c32)cc1 10.1016/0960-894X(95)00477-B
CHEMBL431592 167379 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 712 15 1 10 7.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccn(C(C(=O)OC(C)C)c4ccccc4)c(=O)c32)cc1 10.1016/0960-894X(95)00477-B
10032583 12243 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
CHEMBL1185398 12243 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
CHEMBL411487 12243 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
3082918 94626 1 None - 0 Rat 4.4 pIC50 = 4.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 340 7 1 3 4.2 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL25528 94626 1 None - 0 Rat 4.4 pIC50 = 4.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 340 7 1 3 4.2 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
60148656 92195 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 457 7 2 5 5.9 CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435829 92195 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 457 7 2 5 5.9 CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
44322233 111140 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 644 12 2 11 4.5 CCCCc1nc(SC)c(C(=O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL328480 111140 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 644 12 2 11 4.5 CCCCc1nc(SC)c(C(=O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10047444 99883 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL289543 99883 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
10010047 206212 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 712 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 10.1021/jm00043a020
CHEMBL97020 206212 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 712 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 10.1021/jm00043a020
164611656 184154 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1067 27 14 12 0.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4850726 184154 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1067 27 14 12 0.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
44348408 113074 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm00075a033
CHEMBL332239 113074 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm00075a033
10055096 97833 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 656 15 1 7 7.3 CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL274712 97833 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 656 15 1 7 7.3 CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10054188 205788 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 592 9 1 7 5.1 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL94582 205788 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 592 9 1 7 5.1 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
9939191 98489 1 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL279629 98489 1 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL97539 98489 1 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
9829012 92124 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL24322 92124 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
9829012 92124 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL24322 92124 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44376781 55979 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 517 10 2 6 4.8 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL162859 55979 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 517 10 2 6 4.8 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
9829012 92124 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
CHEMBL24322 92124 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
9895635 111531 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 10.1021/jm00043a020
CHEMBL328941 111531 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 10.1021/jm00043a020
10484119 167545 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL432822 167545 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 10.1021/jm00043a020
10075750 107072 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 532 10 1 7 4.8 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL318891 107072 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 532 10 1 7 4.8 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
44323291 204815 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.4 CCCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL88600 204815 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.4 CCCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10095637 49697 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15689 49697 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
10009735 157660 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 676 3 1 7 6.9 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL408798 157660 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 676 3 1 7 6.9 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 10.1016/0960-894X(96)00116-3
10004112 25326 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm9504722
CHEMBL135089 25326 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm9504722
44311683 105139 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 789 16 1 10 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL312301 105139 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 789 16 1 10 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311618 162785 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 772 16 2 8 7.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL419073 162785 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 772 16 2 8 7.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311581 167270 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 720 17 2 9 7.3 CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL430792 167270 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 720 17 2 9 7.3 CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311415 202386 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70161 202386 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311582 202507 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 790 21 1 9 8.5 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70868 202507 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 790 21 1 9 8.5 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44321790 204886 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 634 13 4 8 4.9 C=CC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89052 204886 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 634 13 4 8 4.9 C=CC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381656 119762 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 12 2 9 6.4 CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352458 119762 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 12 2 9 6.4 CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
44330904 4280 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 698 19 1 8 7.3 CCCC(=O)N(CCC)CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL101039 4280 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 698 19 1 8 7.3 CCCC(=O)N(CCC)CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10373120 117098 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 117098 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
15284887 164928 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 607 6 2 5 4.7 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc(I)c1O 10.1016/S0960-894X(00)80690-3
CHEMBL424004 164928 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 607 6 2 5 4.7 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc(I)c1O 10.1016/S0960-894X(00)80690-3
44381427 119767 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 632 14 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352503 119767 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 632 14 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10259525 15443 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 15443 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9987614 168008 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL435792 168008 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44321823 204497 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 696 13 4 8 6.1 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL86617 204497 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 696 13 4 8 6.1 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
19939753 202059 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 605 13 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67921 202059 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 605 13 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10100951 114546 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 114546 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
44371045 119306 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 4 6.0 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL348363 119306 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 4 6.0 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
10344854 57300 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2C(=O)O 10.1016/j.bmc.2010.10.043
CHEMBL1668009 57300 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2C(=O)O 10.1016/j.bmc.2010.10.043
10053595 102641 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 562 10 2 8 4.8 CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL307756 102641 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 562 10 2 8 4.8 CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311638 102452 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 613 18 1 8 6.7 CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306186 102452 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 613 18 1 8 6.7 CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44303230 198963 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL59957 198963 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80554-0
44303232 201027 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 434 8 1 6 4.8 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl 10.1016/S0960-894X(01)80554-0
CHEMBL61754 201027 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 434 8 1 6 4.8 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl 10.1016/S0960-894X(01)80554-0
44311636 202429 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 549 9 2 9 3.8 CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70389 202429 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 549 9 2 9 3.8 CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222103 202834 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 678 12 2 9 5.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL72819 202834 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 678 12 2 9 5.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(00)80076-1
44376746 119354 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 568 16 2 7 5.9 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL348758 119354 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 568 16 2 7 5.9 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
44303230 198963 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL59957 198963 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
11764669 66486 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.5 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL18606 66486 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.5 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10233056 106675 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 637 10 1 8 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 10.1021/jm00043a020
CHEMBL316297 106675 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 637 10 1 8 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 10.1021/jm00043a020
10009478 111980 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1021/jm00043a020
CHEMBL329858 111980 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1021/jm00043a020
10032361 112229 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 10.1021/jm00043a020
CHEMBL330463 112229 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 10.1021/jm00043a020
10100723 205715 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 646 9 1 7 6.1 CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL94176 205715 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 646 9 1 7 6.1 CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
44303230 198963 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL59957 198963 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
11741658 18625 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 399 4 0 3 4.3 COC(=O)C1Cc2c(C)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL127844 18625 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 399 4 0 3 4.3 COC(=O)C1Cc2c(C)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
108185 1584 71 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
586 1584 71 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
CHEMBL907 1584 71 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
1610 2315 89 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
3941 2315 89 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
3961 2315 89 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
590 2315 89 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
CHEMBL191 2315 89 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
DB00678 2315 89 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
183134 203136 13 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00050a002
CHEMBL7550 203136 13 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00050a002
44475943 188122 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1508 12 8 32 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL504492 188122 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1508 12 8 32 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
44309703 171986 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL448476 171986 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
10417031 106902 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 669 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 10.1021/jm00043a020
CHEMBL317864 106902 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 669 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 10.1021/jm00043a020
9986951 206032 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 10.1021/jm00043a020
CHEMBL95955 206032 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 10.1021/jm00043a020
10416422 206260 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 620 9 1 7 5.8 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97295 206260 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 620 9 1 7 5.8 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10416836 107418 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 651 11 1 8 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm00043a020
CHEMBL319313 107418 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 651 11 1 8 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm00043a020
9888876 48725 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15606 48725 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 10.1016/0960-894X(95)00185-V
73353934 92190 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 469 9 2 4 6.4 CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
CHEMBL2435824 92190 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 469 9 2 4 6.4 CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
10372093 112265 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
CHEMBL330533 112265 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
44376822 119548 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 565 10 1 7 5.5 CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350493 119548 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 565 10 1 7 5.5 CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
44274823 98618 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL280526 98618 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
9830839 106448 0 None - 2 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1021/jm00043a020
CHEMBL314812 106448 0 None - 2 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1021/jm00043a020
44379183 120302 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 571 10 1 6 6.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL355708 120302 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 571 10 1 6 6.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1016/S0960-894X(01)81125-2
11758341 116780 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 603 13 1 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 10.1021/jm00019a005
CHEMBL339544 116780 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 603 13 1 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 10.1021/jm00019a005
10326942 111901 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 10.1021/jm00043a020
CHEMBL329693 111901 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 10.1021/jm00043a020
10100074 112068 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 9 1 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL330007 112068 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 9 1 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1021/jm00043a020
44379184 57148 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 602 14 2 7 5.9 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL165541 57148 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 602 14 2 7 5.9 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1016/S0960-894X(01)81125-2
44323351 106537 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3Cl)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL315401 106537 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3Cl)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10394829 118855 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344387 118855 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10485202 118915 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344811 118915 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9873751 95973 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 614 12 1 8 5.9 CCCCc1nc2ccn(C(C(=O)N(CC)CC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL261981 95973 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 614 12 1 8 5.9 CCCCc1nc2ccn(C(C(=O)N(CC)CC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323290 106417 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 587 10 1 9 5.6 CCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL314603 106417 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 587 10 1 9 5.6 CCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44381431 58193 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 578 11 1 9 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168346 58193 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 578 11 1 9 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10078452 106794 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1021/jm00043a020
CHEMBL317061 106794 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1021/jm00043a020
44377123 119470 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 481 10 2 6 3.9 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349856 119470 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 481 10 2 6 3.9 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
10391038 116432 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 494 13 0 6 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1021/jm00019a005
CHEMBL338514 116432 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 494 13 0 6 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1021/jm00019a005
44309701 102711 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 609 11 2 7 6.3 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL308238 102711 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 609 11 2 7 6.3 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
15230312 48650 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1cc2c(cc1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155987 48650 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1cc2c(cc1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
164620345 185631 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4873167 185631 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
10054324 97901 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL275160 97901 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
9908300 15371 0 None - 0 Rat 4.2 pIC50 = 4.2 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 387 8 2 5 3.9 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1021/jm00053a013
CHEMBL12190 15371 0 None - 0 Rat 4.2 pIC50 = 4.2 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 387 8 2 5 3.9 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1021/jm00053a013
73357016 92191 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 503 8 2 4 7.0 CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435825 92191 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 503 8 2 4 7.0 CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL408773 210984 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS2 10.1021/jm00065a013
10462933 16702 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 16702 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9850834 154124 13 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
CHEMBL39959 154124 13 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
9874508 202974 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 202974 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44210586 58703 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 12 3 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169221 58703 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 12 3 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10101690 116361 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 116361 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395394 31664 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL140708 31664 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44314780 102604 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 102604 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10010207 29981 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139041 29981 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44315180 102423 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 102423 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
19763341 61656 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 448 8 1 6 5.2 CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00137a004
CHEMBL177435 61656 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 448 8 1 6 5.2 CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00137a004
5311345 2972 39 None 10 2 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)80517-5
597 2972 39 None 10 2 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)80517-5
CHEMBL321820 2972 39 None 10 2 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)80517-5
5311345 2972 39 None 10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)81122-7
597 2972 39 None 10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)81122-7
CHEMBL321820 2972 39 None 10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)81122-7
9804437 117562 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 463 6 1 3 5.6 O=C(O)C1Cc2cc(Oc3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340467 117562 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 463 6 1 3 5.6 O=C(O)C1Cc2cc(Oc3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
9915892 103143 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308703 103143 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
10417351 206219 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 706 10 1 8 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL97075 206219 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 706 10 1 8 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 10.1021/jm00043a020
9895984 203041 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
CHEMBL74476 203041 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
9915892 103143 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL308703 103143 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
19385644 98296 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 519 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 10.1016/0960-894X(95)00185-V
CHEMBL278061 98296 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 519 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 10.1016/0960-894X(95)00185-V
44311429 202910 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 649 11 1 8 6.8 CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL73369 202910 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 649 11 1 8 6.8 CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10318033 117770 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 387 4 2 3 3.6 O=C(O)C1Cc2cc(O)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340933 117770 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 387 4 2 3 3.6 O=C(O)C1Cc2cc(O)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44311342 101711 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 611 12 3 7 5.9 CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL302760 101711 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 611 12 3 7 5.9 CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222094 102501 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 596 10 2 8 5.4 CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306489 102501 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 596 10 2 8 5.4 CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222101 158016 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 642 12 2 9 4.2 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL409170 158016 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 642 12 2 9 4.2 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(00)80076-1
44311688 103719 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 554 10 2 8 3.5 CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309820 103719 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 554 10 2 8 3.5 CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
14952909 147543 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1C(=O)O 10.1021/jm00108a043
CHEMBL39349 147543 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1C(=O)O 10.1021/jm00108a043
73357018 92200 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 8 2 4 7.3 CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435834 92200 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 8 2 4 7.3 CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
19385598 98406 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 6 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 10.1016/0960-894X(95)00185-V
CHEMBL278955 98406 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 6 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 10.1016/0960-894X(95)00185-V
44379291 120007 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 702 15 2 8 7.5 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL354535 120007 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 702 15 2 8 7.5 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)81125-2
14952916 99684 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc([N+](=O)[O-])cc1 10.1021/jm00108a043
CHEMBL287762 99684 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc([N+](=O)[O-])cc1 10.1021/jm00108a043
44384872 59680 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 575 9 3 7 4.4 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/0960-894X(96)00116-3
CHEMBL173455 59680 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 575 9 3 7 4.4 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/0960-894X(96)00116-3
CHEMBL440063 212109 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC)CSSC[C@H](C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
44315349 60071 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 60071 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315350 104739 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 104739 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10259334 206298 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 13 1 10 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00043a020
CHEMBL97500 206298 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 13 1 10 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00043a020
114899 2971 11 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 10.1021/jm00137a004
596 2971 11 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 10.1021/jm00137a004
CHEMBL1188080 2971 11 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 10.1021/jm00137a004
5311348 100206 3 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm9504722
CHEMBL292277 100206 3 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm9504722
44379086 56284 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 543 9 1 6 5.4 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164174 56284 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 543 9 1 6 5.4 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44311074 104421 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 732 15 1 10 6.2 CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL311253 104421 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 732 15 1 10 6.2 CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9938088 102008 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1016/S0960-894X(01)80554-0
CHEMBL304022 102008 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1016/S0960-894X(01)80554-0
9851889 101604 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL302102 101604 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44303883 201213 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 634 11 1 3 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62744 201213 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 634 11 1 3 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
9938088 102008 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
CHEMBL304022 102008 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
44382994 96456 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 933 25 7 10 5.8 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)[C@@H](N)CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 10.1016/S0960-894X(00)80690-3
CHEMBL265790 96456 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 933 25 7 10 5.8 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)[C@@H](N)CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 10.1016/S0960-894X(00)80690-3
CHEMBL384125 210570 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSS[C@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
44381657 58749 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169488 58749 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10372550 163964 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 163964 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314823 161338 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 161338 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
44314822 102476 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 102476 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44303885 201214 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 538 12 1 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(OC)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62754 201214 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 538 12 1 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(OC)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10413312 116808 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 1 3 5.8 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
CHEMBL339706 116808 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 1 3 5.8 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
10344278 117680 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340902 117680 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44323559 205283 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 628 10 1 9 4.9 CCCCc1nc2ccn(C(C(=O)N3CCOCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL91465 205283 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 628 10 1 9 4.9 CCCCc1nc2ccn(C(C(=O)N3CCOCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44311451 103625 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 576 10 2 8 5.1 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309367 103625 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 576 10 2 8 5.1 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
18655106 198785 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)81007-6
CHEMBL59854 198785 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)81007-6
15296723 48601 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 7 1 4 5.2 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Cc1c(Cl)cccc1Cl)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155938 48601 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 7 1 4 5.2 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Cc1c(Cl)cccc1Cl)C2 10.1016/S0960-894X(01)81122-7
14403498 100562 3 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm9504722
CHEMBL294558 100562 3 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm9504722
164612059 183919 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1123 30 14 12 1.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4847398 183919 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1123 30 14 12 1.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
44303614 198983 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 478 8 1 6 4.9 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
CHEMBL59974 198983 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 478 8 1 6 4.9 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
15222070 101827 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 9 2 9 3.8 CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL303426 101827 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 9 2 9 3.8 CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311648 202822 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 11 2 9 4.5 CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL72721 202822 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 11 2 9 4.5 CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
10349256 110968 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 647 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 10.1021/jm00043a020
CHEMBL327569 110968 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 647 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 10.1021/jm00043a020
10461595 206380 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 10.1021/jm00043a020
CHEMBL97964 206380 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 10.1021/jm00043a020
10254358 116992 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 475 6 0 3 5.5 COC(=O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340018 116992 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 475 6 0 3 5.5 COC(=O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44311472 103316 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 669 14 3 8 5.7 CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308943 103316 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 669 14 3 8 5.7 CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44377199 57118 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 531 10 2 6 4.9 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL165349 57118 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 531 10 2 6 4.9 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
73353933 92187 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 554 11 2 6 5.2 CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435821 92187 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 554 11 2 6 5.2 CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
10078132 106767 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 10.1021/jm00043a020
CHEMBL316904 106767 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 10.1021/jm00043a020
10078048 106397 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 12 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1021/jm00043a020
CHEMBL314514 106397 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 12 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1021/jm00043a020
10411441 51513 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL15850 51513 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
15230316 119587 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 522 7 1 6 5.3 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc(N)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL350875 119587 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 522 7 1 6 5.3 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc(N)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
44348259 15856 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 575 12 1 5 8.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 10.1021/jm00075a033
CHEMBL122367 15856 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 575 12 1 5 8.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 10.1021/jm00075a033
1610 2315 89 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
3941 2315 89 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
3961 2315 89 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
590 2315 89 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
CHEMBL191 2315 89 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
DB00678 2315 89 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
1610 2315 89 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
3941 2315 89 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
3961 2315 89 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
590 2315 89 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
CHEMBL191 2315 89 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
DB00678 2315 89 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
10393837 167381 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 602 10 1 8 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 10.1021/jm00043a020
CHEMBL431619 167381 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 602 10 1 8 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 10.1021/jm00043a020
44211672 157661 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 706 4 1 8 7.4 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL408799 157661 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 706 4 1 8 7.4 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
9892451 48476 17 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/acs.jmedchem.9b01780
CHEMBL155836 48476 17 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/acs.jmedchem.9b01780
15296726 51594 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 2 5 5.1 COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL158557 51594 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 2 5 5.1 COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
18950598 15367 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C 10.1021/jm00075a033
CHEMBL121891 15367 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C 10.1021/jm00075a033
10483888 110967 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1021/jm00043a020
CHEMBL327563 110967 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1021/jm00043a020
18950607 50147 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 489 9 1 5 6.2 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15729 50147 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 489 9 1 5 6.2 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
9933755 54761 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 456 9 1 5 5.3 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL16165 54761 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 456 9 1 5 5.3 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
73355475 92193 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 9 2 4 6.9 CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435827 92193 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 9 2 4 6.9 CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
9807029 201415 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL63998 201415 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1016/S0960-894X(01)80554-0
9807029 201415 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1021/jm9504722
CHEMBL63998 201415 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1021/jm9504722
73347892 92189 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 455 8 2 4 6.1 CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435823 92189 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 455 8 2 4 6.1 CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
25135102 188283 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1495 12 10 32 3.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL507053 188283 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1495 12 10 32 3.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
10349801 107452 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL319353 107452 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 10.1021/jm00043a020
19385586 49458 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 479 8 1 6 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
CHEMBL15669 49458 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 479 8 1 6 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
10414470 16948 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 524 11 2 7 4.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00019a005
CHEMBL125542 16948 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 524 11 2 7 4.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00019a005
44322176 204950 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 646 13 3 11 4.4 CCCCc1nc(SC)c(C(O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89463 204950 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 646 13 3 11 4.4 CCCCc1nc(SC)c(C(O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381622 58712 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 689 12 2 9 5.8 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169279 58712 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 689 12 2 9 5.8 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
44315078 203048 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 203048 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19102815 206142 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL96554 206142 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
44321775 106516 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 588 13 4 8 4.4 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL315275 106516 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 588 13 4 8 4.4 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
10439858 16682 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 16682 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
5311345 2972 39 None 10 2 Human 8.1 pIC50 = 8.1 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(00)80690-3
597 2972 39 None 10 2 Human 8.1 pIC50 = 8.1 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(00)80690-3
CHEMBL321820 2972 39 None 10 2 Human 8.1 pIC50 = 8.1 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(00)80690-3
44381670 119978 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 657 11 3 9 6.0 CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354298 119978 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 657 11 3 9 6.0 CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 10.1016/S0960-894X(01)81126-4
44315282 96176 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 96176 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
10344278 117680 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340902 117680 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44303211 100132 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomesCompound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomes
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
CHEMBL291803 100132 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomesCompound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomes
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
44303404 198024 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL59331 198024 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL264450 208874 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CCSSCC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
44311498 102457 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 580 10 2 8 4.9 CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306216 102457 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 580 10 2 8 4.9 CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222092 103347 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 564 10 2 10 3.5 CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309165 103347 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 564 10 2 10 3.5 CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44379182 57814 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 593 10 1 6 6.7 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167662 57814 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 593 10 1 6 6.7 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
9961192 11261 34 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
CHEMBL1179743 11261 34 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
CHEMBL97688 11261 34 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
10417102 205713 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 676 10 1 9 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 10.1021/jm00043a020
CHEMBL94145 205713 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 676 10 1 9 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 10.1021/jm00043a020
44303211 100132 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1021/jm9504722
CHEMBL291803 100132 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1021/jm9504722
18950608 15495 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 10.1021/jm00075a033
CHEMBL122224 15495 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 10.1021/jm00075a033
44311568 97732 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 13 2 8 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL273992 97732 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 13 2 8 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44270367 162672 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 505 9 1 5 6.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 10.1016/0960-894X(95)00185-V
CHEMBL418354 162672 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 505 9 1 5 6.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 10.1016/0960-894X(95)00185-V
44377111 119379 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 495 10 1 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349020 119379 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 495 10 1 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
44210830 57181 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 461 6 1 6 5.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 10.1016/S0960-894X(01)80193-1
CHEMBL165850 57181 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 461 6 1 6 5.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 10.1016/S0960-894X(01)80193-1
10054708 106670 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 10.1021/jm00043a020
CHEMBL316273 106670 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 10.1021/jm00043a020
44304163 201097 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 496 17 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(CCCCC)CCCCC)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62157 201097 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 496 17 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(CCCCC)CCCCC)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10350378 206458 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 796 10 1 8 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 10.1021/jm00043a020
CHEMBL98453 206458 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 796 10 1 8 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 10.1021/jm00043a020
44574325 188164 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1521 12 8 32 4.8 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL505204 188164 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1521 12 8 32 4.8 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL413034 211300 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
9874086 108626 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 10.1021/jm00043a020
CHEMBL321367 108626 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 10.1021/jm00043a020
19939756 4969 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 534 9 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL105199 4969 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 534 9 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
10349845 11257 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
CHEMBL1179731 11257 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
CHEMBL97271 11257 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
164627947 185803 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4875696 185803 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
10426066 100042 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 318 7 1 3 4.0 CCCCc1ncc(/C=C/C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL291114 100042 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 318 7 1 3 4.0 CCCCc1ncc(/C=C/C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
44311454 102472 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 692 17 2 8 6.9 CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL306340 102472 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 692 17 2 8 6.9 CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311436 202487 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 8 8.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70793 202487 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 8 8.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44303420 200058 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(C)c1 10.1016/S0960-894X(01)80554-0
CHEMBL60661 200058 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(C)c1 10.1016/S0960-894X(01)80554-0
44321804 105500 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 690 13 4 8 5.7 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL313073 105500 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 690 13 4 8 5.7 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL406290 210856 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSS[C@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
15292111 203037 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 203037 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315304 203301 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 203301 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
15230313 48350 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 446 6 1 4 4.3 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(C)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155728 48350 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 446 6 1 4 4.3 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(C)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
15292112 102475 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 102475 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10368357 116768 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 7 1 3 5.5 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL339485 116768 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 7 1 3 5.5 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
10344278 117680 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340902 117680 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44311739 102134 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 14 2 7 6.2 CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
CHEMBL304137 102134 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 14 2 7 6.2 CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
44311662 102208 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 624 17 2 7 5.8 CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC 10.1016/S0960-894X(00)80076-1
CHEMBL304620 102208 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 624 17 2 7 5.8 CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC 10.1016/S0960-894X(00)80076-1
44311650 102726 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 674 14 2 10 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308361 102726 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 674 14 2 10 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
14952904 99701 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 396 9 2 5 4.8 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1O 10.1021/jm00108a043
CHEMBL287936 99701 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 396 9 2 5 4.8 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1O 10.1021/jm00108a043
44309704 202575 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 612 13 1 7 7.7 CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
CHEMBL71253 202575 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 612 13 1 7 7.7 CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
44300798 197277 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 558 8 1 7 6.1 CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL58499 197277 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 558 8 1 7 6.1 CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
9805344 98583 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 483 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL280290 98583 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 483 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
10372718 108070 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 722 10 1 7 7.4 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl 10.1021/jm00043a020
CHEMBL320222 108070 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 722 10 1 7 7.4 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl 10.1021/jm00043a020
9809280 203264 6 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL76525 203264 6 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL80370 203264 6 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
9809280 203264 6 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1021/jm9504722
CHEMBL76525 203264 6 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1021/jm9504722
CHEMBL80370 203264 6 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1021/jm9504722
19385623 50164 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15730 50164 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 10.1016/0960-894X(95)00185-V
44335530 107023 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 520 9 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL318605 107023 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 520 9 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
44323292 163250 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.2 CCCCc1nc2ccn(C(C(=O)OCC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL420607 163250 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.2 CCCCc1nc2ccn(C(C(=O)OCC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323363 111116 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 558 10 2 8 4.5 CCCCc1nc2ccn(C(C(N)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL328340 111116 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 558 10 2 8 4.5 CCCCc1nc2ccn(C(C(N)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44379185 57250 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 603 13 2 7 5.6 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL166428 57250 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 603 13 2 7 5.6 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 10.1016/S0960-894X(01)81125-2
19742811 57120 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL165354 57120 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
56661223 62922 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791308 62922 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL2392353 208669 6 None - 1 Human 10.0 pKi = 10.0 Binding
Binding affinity to human AT2 receptor by radioligand displacement assayBinding affinity to human AT2 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
10079601 210784 17 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1021/ml500278g
CHEMBL404594 210784 17 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1021/ml500278g
10079601 210784 17 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1016/j.bmcl.2015.10.084
CHEMBL404594 210784 17 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1016/j.bmcl.2015.10.084
CHEMBL938 214130 24 None -1 2 Human 9.8 pKi = 9.8 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm8007618
CHEMBL216061 207571 10 None -1 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
16133225 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
172198 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
2504 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
45266664 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
5272 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
CHEMBL408403 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
DB11842 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
16133225 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
172198 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
2504 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
45266664 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
5272 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
CHEMBL408403 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
DB11842 415 47 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
16133225 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
172198 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
2504 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
45266664 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
5272 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
CHEMBL408403 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
DB11842 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
16133225 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
172198 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
2504 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
45266664 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
5272 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
CHEMBL408403 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
DB11842 415 47 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
56661223 62922 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791308 62922 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
16133225 415 47 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
172198 415 47 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
2504 415 47 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
45266664 415 47 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
5272 415 47 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
CHEMBL408403 415 47 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
DB11842 415 47 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
CHEMBL938 214130 24 None -1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/ml500278g
CHEMBL938 214130 24 None -1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.bmcl.2015.10.084
6918 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptorBinding affinity to AT2 receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2010.03.064
9804984 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptorBinding affinity to AT2 receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2010.03.064
CHEMBL189568 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptorBinding affinity to AT2 receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2010.03.064
6918 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
6918 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/ml500278g
9804984 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
9804984 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/ml500278g
CHEMBL189568 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
CHEMBL189568 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/ml500278g
6918 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2015.10.084
9804984 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2015.10.084
CHEMBL189568 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2015.10.084
6918 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/jm049715t
9804984 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/jm049715t
CHEMBL189568 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/jm049715t
11317806 123125 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 489 10 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 10.1021/jm049715t
CHEMBL361927 123125 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 489 10 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 10.1021/jm049715t
11994291 80316 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 485 12 1 7 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL215160 80316 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 485 12 1 7 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11994289 82065 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217673 82065 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
16133225 415 47 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
172198 415 47 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
2504 415 47 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
45266664 415 47 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
5272 415 47 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
CHEMBL408403 415 47 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
DB11842 415 47 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
CHEMBL404996 210792 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None CCSC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm030921v
CHEMBL3350599 209735 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](N)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
11994289 82065 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL217673 82065 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/acs.jmedchem.5b00982
11994289 82065 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL217673 82065 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL268815 209021 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm051222g
10463891 96466 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL265881 96466 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL268815 209021 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm0491492
CHEMBL424755 211576 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)O 10.1021/jm0613469
44398242 66880 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
CHEMBL187880 66880 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
10163396 81166 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 489 12 1 7 4.5 CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216250 81166 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 489 12 1 7 4.5 CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168283461 190389 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 10 1 8 4.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5186237 190389 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 10 1 8 4.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
16133225 415 47 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
172198 415 47 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
2504 415 47 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
45266664 415 47 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
5272 415 47 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
CHEMBL408403 415 47 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
DB11842 415 47 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
168273584 189619 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 503 8 1 10 4.2 CCCc1nc(-c2ccc(Cn3ccnc3-c3nccs3)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5174659 189619 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 503 8 1 10 4.2 CCCc1nc(-c2ccc(Cn3ccnc3-c3nccs3)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL268815 209021 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm049651m
9850834 154124 13 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL39959 154124 13 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
16087342 141181 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
CHEMBL385706 141181 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
11564291 166541 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1008 26 12 12 -0.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL428986 166541 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1008 26 12 12 -0.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
10160913 141275 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL386269 141275 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11766283 71236 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 909 23 11 11 -0.2 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL196316 71236 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 909 23 11 11 -0.2 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
168270996 189466 0 None 64 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 533 11 1 6 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5172324 189466 0 None 64 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 533 11 1 6 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168291545 191393 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 597 10 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1cc(F)c(Cn2c(C(C)(C)C)nc3ccccc32)c(F)c1 10.1016/j.bmc.2022.116804
CHEMBL5201369 191393 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 597 10 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1cc(F)c(Cn2c(C(C)(C)C)nc3ccccc32)c(F)c1 10.1016/j.bmc.2022.116804
162660565 180740 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 9 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
CHEMBL4762752 180740 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 9 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
CHEMBL426885 211603 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)O 10.1021/jm0613469
56657702 62923 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791309 62923 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
168290795 191350 0 None 33 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 559 11 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5200734 191350 0 None 33 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 559 11 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168292515 191441 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2cc(F)c(Cn3c(C(C)(C)C)nc4ccccc43)c(F)c2)c1 10.1016/j.bmc.2022.116804
CHEMBL5202149 191441 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2cc(F)c(Cn3c(C(C)(C)C)nc4ccccc43)c(F)c2)c1 10.1016/j.bmc.2022.116804
118725967 116696 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
CHEMBL3394207 116696 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
118725967 116696 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
CHEMBL3394207 116696 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
168274956 189744 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 10 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(F)(F)F)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5176607 189744 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 10 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(F)(F)F)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10227337 81244 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216361 81244 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168296606 191850 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 587 11 1 6 8.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5208437 191850 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 587 11 1 6 8.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
145963801 163509 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4209214 163509 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
11365721 98214 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 640 13 1 10 6.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1021/jm031031i
CHEMBL277388 98214 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 640 13 1 10 6.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1021/jm031031i
168287840 190712 0 None 32 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 12 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5191241 190712 0 None 32 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 12 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
145978135 163337 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 9 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCC2CC2)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4207027 163337 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 9 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCC2CC2)s1 10.1016/j.bmcl.2017.11.042
168295859 191687 0 None -50 2 Human 5.9 pKi = 5.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 569 11 1 9 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205969 191687 0 None -50 2 Human 5.9 pKi = 5.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 569 11 1 9 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
168288075 191066 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 595 12 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(Cc3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5196244 191066 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 595 12 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(Cc3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
11994292 81574 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 471 10 1 7 4.6 CCCCOC(=O)NS(=O)(=O)c1ccc(OC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216515 81574 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 471 10 1 7 4.6 CCCCOC(=O)NS(=O)(=O)c1ccc(OC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168285844 190973 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 8 1 8 4.2 CCCc1nc(-c2ccc(Cn3ccnc3C(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5194914 190973 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 8 1 8 4.2 CCCc1nc(-c2ccc(Cn3ccnc3C(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
44420775 137358 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 315 7 2 4 2.2 CC[C@@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1021/jm0613469
CHEMBL376286 137358 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 315 7 2 4 2.2 CC[C@@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1021/jm0613469
145965121 163874 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4213607 163874 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1016/j.bmcl.2017.11.042
11296725 99909 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 652 13 2 9 6.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(C)=O)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL289803 99909 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 652 13 2 9 6.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(C)=O)cc3c2=O)cc1 10.1021/jm031031i
9830680 100176 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
CHEMBL292150 100176 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
162657895 180477 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 12 1 8 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4759641 180477 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 12 1 8 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)C)c1 10.1016/j.bmc.2020.115859
56964910 77091 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/ml500278g
CHEMBL2086892 77091 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/ml500278g
56964910 77091 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
CHEMBL2086892 77091 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
162675267 182775 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 8 1 7 4.8 CC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4797684 182775 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 8 1 7 4.8 CC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
11764788 100391 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
CHEMBL293501 100391 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
158303357 191634 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 532 10 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205106 191634 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 532 10 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
166492461 191216 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 474 8 1 8 4.2 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5198482 191216 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 474 8 1 8 4.2 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
145977406 163296 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 487 8 1 7 5.2 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC2CCCC2)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4206507 163296 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 487 8 1 7 5.2 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC2CCCC2)s1 10.1016/j.bmcl.2017.11.042
73213176 104222 0 None - 1 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 454 9 2 6 2.6 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2013.12.040
CHEMBL3105392 104222 0 None - 1 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 454 9 2 6 2.6 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2013.12.040
11995658 81726 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 364 6 1 6 4.0 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(-c2nn[nH]n2)s1 10.1021/jm0606185
CHEMBL216746 81726 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 364 6 1 6 4.0 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(-c2nn[nH]n2)s1 10.1021/jm0606185
168274734 190072 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 12 1 6 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5181652 190072 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 12 1 6 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
166492455 190814 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 7 1 8 4.4 CCCc1nc(-c2ccc(Cn3ccnc3C(C)(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5192639 190814 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 7 1 8 4.4 CCCc1nc(-c2ccc(Cn3ccnc3C(C)(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
3936 2180 28 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
6603900 2180 28 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
CHEMBL288174 2180 28 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
11994290 79990 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 441 9 1 6 4.4 CCCCc1ccc(S(=O)(=O)NC(=O)OCC)c(-c2ccc(Cn3ccnc3)cc2)c1 10.1021/jm0606185
CHEMBL214525 79990 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 441 9 1 6 4.4 CCCCc1ccc(S(=O)(=O)NC(=O)OCC)c(-c2ccc(Cn3ccnc3)cc2)c1 10.1021/jm0606185
CHEMBL268815 209021 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm030921v
10031067 99888 3 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL289614 99888 3 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL216331 207578 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm049651m
56657702 62923 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791309 62923 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
168277309 189634 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 448 8 1 8 3.7 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5174923 189634 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 448 8 1 8 3.7 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
3936 2180 28 None -2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
6603900 2180 28 None -2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
CHEMBL288174 2180 28 None -2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
44400670 158346 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 993 23 12 13 -0.7 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL409528 158346 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 993 23 12 13 -0.7 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
3936 2180 28 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
6603900 2180 28 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
CHEMBL288174 2180 28 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
168277868 189883 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 10 1 8 4.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5178914 189883 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 10 1 8 4.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
145978497 163102 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 10 1 7 5.3 CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4204342 163102 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 10 1 7 5.3 CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145972310 164015 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 9 1 6 4.6 CCN(CC)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4215292 164015 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 9 1 6 4.6 CCN(CC)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
45102601 169004 9 None -1995 2 Human 5.6 pKi = 5.6 Binding
Displacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 6 5.4 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
CHEMBL4435800 169004 9 None -1995 2 Human 5.6 pKi = 5.6 Binding
Displacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 6 5.4 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
162651258 179755 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 13 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCC)c1 10.1016/j.bmc.2020.115859
CHEMBL4751226 179755 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 13 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCC)c1 10.1016/j.bmc.2020.115859
166492466 191345 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 8 1 8 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5200682 191345 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 8 1 8 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
56964910 77091 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
CHEMBL2086892 77091 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
56964910 77091 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL2086892 77091 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145967796 164281 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4218765 164281 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1016/j.bmcl.2017.11.042
67132863 77094 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 503 11 1 8 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
CHEMBL2086910 77094 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 503 11 1 8 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
145976243 162974 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 11 1 6 5.2 CCCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4202730 162974 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 11 1 6 5.2 CCCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
163408877 190105 2 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 490 7 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5182186 190105 2 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 490 7 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
168277087 189892 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 505 10 1 6 5.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5179052 189892 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 505 10 1 6 5.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1016/j.bmc.2022.116804
145969149 164217 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 9 1 7 4.7 CCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4217991 164217 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 9 1 7 4.7 CCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
73213178 104223 0 None - 1 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 483 10 3 6 2.4 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2013.12.040
CHEMBL3105394 104223 0 None - 1 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 483 10 3 6 2.4 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2013.12.040
10057017 161278 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm030921v
CHEMBL414478 161278 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm030921v
10057017 161278 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm0491492
CHEMBL414478 161278 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm0491492
168272246 189898 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 477 10 1 8 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cc2ncco2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5179119 189898 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 477 10 1 8 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cc2ncco2)cc1 10.1016/j.bmc.2022.116790
10196520 67302 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 553 11 1 7 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1021/jm049715t
CHEMBL190577 67302 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 553 11 1 7 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1021/jm049715t
6918 1013 29 None -3 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116804
9804984 1013 29 None -3 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116804
CHEMBL189568 1013 29 None -3 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116804
44398381 67264 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
CHEMBL190286 67264 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
10054827 163586 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
CHEMBL42101 163586 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
145978684 163009 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 445 9 1 6 4.5 CCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4203099 163009 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 445 9 1 6 4.5 CCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145974498 164174 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4217484 164174 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
168287782 191228 0 None 22 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 545 11 1 6 6.8 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5198739 191228 0 None 22 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 545 11 1 6 6.8 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10277322 141256 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL386172 141256 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11274375 99996 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 804 16 1 9 9.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL290708 99996 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 804 16 1 9 9.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
163409135 189590 2 None -37 2 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 623 11 1 9 6.5 CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmc.2022.116790
CHEMBL5174180 189590 2 None -37 2 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 623 11 1 9 6.5 CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmc.2022.116790
11216369 99906 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL289775 99906 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
11994293 81889 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.9 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217208 81889 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.9 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
145976532 163054 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 443 8 1 6 4.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)C2CC2)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4203624 163054 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 443 8 1 6 4.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)C2CC2)s1 10.1016/j.bmcl.2017.11.042
168279676 190535 0 None 11 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5188126 190535 0 None 11 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
166492421 190031 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 545 11 1 10 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5181087 190031 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 545 11 1 10 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
10116410 140987 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL384577 140987 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11445913 133099 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 908 19 10 12 0.3 C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL371395 133099 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 908 19 10 12 0.3 C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
16124929 83032 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 2 4 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cn2ccnc2)c1 10.1021/jm0613469
CHEMBL219840 83032 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 2 4 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cn2ccnc2)c1 10.1021/jm0613469
166492441 190909 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 504 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5193845 190909 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 504 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
162666037 181730 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 14 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCCC)c1 10.1016/j.bmc.2020.115859
CHEMBL4784233 181730 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 14 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCCC)c1 10.1016/j.bmc.2020.115859
8374 2877 36 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
9937291 2877 36 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
CHEMBL34124 2877 36 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
DB16266 2877 36 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
145964638 163831 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 11 1 7 5.5 CCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4213069 163831 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 11 1 7 5.5 CCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
168274602 189782 0 None 97 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 11 1 6 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5177359 189782 0 None 97 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 11 1 6 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
9806878 126998 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 525 10 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1021/jm049715t
CHEMBL366210 126998 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 525 10 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1021/jm049715t
11995655 140965 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 488 10 1 6 5.0 CCCCN(C)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL384462 140965 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 488 10 1 6 5.0 CCCCN(C)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
44212339 203327 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 438 7 1 6 4.9 CCCCc1nc2ccccc2[n+]([O-])c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL77029 203327 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 438 7 1 6 4.9 CCCCc1nc2ccccc2[n+]([O-])c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
168297670 191780 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 615 10 1 6 7.8 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
CHEMBL5207511 191780 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 615 10 1 6 7.8 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
11181498 100043 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 680 14 1 9 6.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL291124 100043 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 680 14 1 9 6.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
16087341 96433 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
CHEMBL265613 96433 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
16124928 83031 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 3 3 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cc2cnc[nH]2)c1 10.1021/jm0613469
CHEMBL219839 83031 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 3 3 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cc2cnc[nH]2)c1 10.1021/jm0613469
11180576 99848 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 566 11 1 7 6.6 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL289306 99848 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 566 11 1 7 6.6 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
145972980 163942 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 433 7 1 7 3.9 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4214477 163942 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 433 7 1 7 3.9 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145972801 164050 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4215828 164050 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
166492420 191660 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 559 11 1 10 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205556 191660 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 559 11 1 10 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
11722069 70223 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 895 22 11 11 0.1 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL194864 70223 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 895 22 11 11 0.1 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
73213175 104221 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 397 8 2 6 3.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1 10.1016/j.bmcl.2013.12.040
CHEMBL3105391 104221 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 397 8 2 6 3.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1 10.1016/j.bmcl.2013.12.040
166492452 190181 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 502 11 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5183386 190181 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 502 11 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
145966800 163474 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 5.1 CCC(C)OC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4208670 163474 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 5.1 CCC(C)OC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
11366289 167450 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 784 18 1 9 9.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)CCCC)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL432095 167450 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 784 18 1 9 9.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)CCCC)cc3c2=O)cc1 10.1021/jm031031i
168283187 190623 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 639 11 1 6 8.4 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C34CC5CC(CC(C5)C3)C4)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5189691 190623 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 639 11 1 6 8.4 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C34CC5CC(CC(C5)C3)C4)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10396262 114935 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1022 27 12 12 0.3 CC[C@H](C)[C@H](NC(=O)c1cc(CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc(Cc2ccc(O)cc2)c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
CHEMBL3350600 114935 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1022 27 12 12 0.3 CC[C@H](C)[C@H](NC(=O)c1cc(CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc(Cc2ccc(O)cc2)c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
16125001 105950 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cells
ChEMBL 315 7 2 4 2.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1016/j.bmcl.2013.12.040
CHEMBL3105395 105950 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cells
ChEMBL 315 7 2 4 2.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1016/j.bmcl.2013.12.040
CHEMBL3139603 105950 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cells
ChEMBL 315 7 2 4 2.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1016/j.bmcl.2013.12.040
11331641 99838 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL289211 99838 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
67133138 77095 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 12 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CC)c1 10.1016/j.bmc.2020.115859
CHEMBL2086911 77095 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 12 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CC)c1 10.1016/j.bmc.2020.115859
10742620 57297 0 None -16 2 Human 6.3 pKi = 6.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 460 7 2 6 5.1 CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1668003 57297 0 None -16 2 Human 6.3 pKi = 6.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 460 7 2 6 5.1 CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
163409136 190308 2 None -18 2 Human 6.3 pKi = 6.3 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 583 11 1 9 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
CHEMBL5185088 190308 2 None -18 2 Human 6.3 pKi = 6.3 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 583 11 1 9 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
145965943 163652 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4210874 163652 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
131590 20503 37 None -16 3 Human 6.3 pKi = 6.3 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm9504722
CHEMBL130896 20503 37 None -16 3 Human 6.3 pKi = 6.3 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm9504722
10276878 80012 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 11 1 6 5.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL214592 80012 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 11 1 6 5.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
10140383 81978 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 11 1 7 5.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217249 81978 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 11 1 7 5.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168271055 189345 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 588 11 1 8 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3nccs3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5170220 189345 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 588 11 1 8 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3nccs3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168272577 189761 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 10 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5176951 189761 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 10 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168277414 189869 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 517 8 1 10 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5178751 189869 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 517 8 1 10 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
166492465 189953 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 11 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5179875 189953 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 11 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
162650706 179458 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 515 10 1 8 5.0 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
CHEMBL4747530 179458 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 515 10 1 8 5.0 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
16087340 165384 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 912 21 10 11 1.2 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
CHEMBL425077 165384 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 912 21 10 11 1.2 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
168292360 191280 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 581 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5199606 191280 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 581 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168278021 189599 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCC(F)(F)C(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
CHEMBL5174301 189599 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCC(F)(F)C(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
11994156 81717 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 10 1 7 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216688 81717 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 10 1 7 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
162663560 181356 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 11 1 8 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4779819 181356 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 11 1 8 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
56678310 62921 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1034 25 11 12 1.0 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)ccc2[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm030921v
CHEMBL1791259 62921 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1034 25 11 12 1.0 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)ccc2[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm030921v
10140382 141344 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1021/jm0606185
CHEMBL386671 141344 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1021/jm0606185
9891811 119237 1 None -8128 2 Rat 5.2 pKi = 5.2 Binding
Receptor binding affinity for Angiotensin II receptor, type 2 determinedReceptor binding affinity for Angiotensin II receptor, type 2 determined
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL347703 119237 1 None -8128 2 Rat 5.2 pKi = 5.2 Binding
Receptor binding affinity for Angiotensin II receptor, type 2 determinedReceptor binding affinity for Angiotensin II receptor, type 2 determined
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL4524047 119237 1 None -8128 2 Rat 5.2 pKi = 5.2 Binding
Receptor binding affinity for Angiotensin II receptor, type 2 determinedReceptor binding affinity for Angiotensin II receptor, type 2 determined
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
10289461 67426 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 526 10 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3cccnc32)cc1 10.1021/jm049715t
CHEMBL190811 67426 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 526 10 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3cccnc32)cc1 10.1021/jm049715t
162663467 181370 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 9 1 8 5.4 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4779945 181370 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 9 1 8 5.4 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
11316477 67752 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 434 9 1 6 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC#N)cc1 10.1021/jm049715t
CHEMBL191468 67752 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 434 9 1 6 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC#N)cc1 10.1021/jm049715t
163848227 189518 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 10 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5173054 189518 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 10 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
145965035 163699 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 529 10 1 7 5.6 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4211391 163699 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 529 10 1 7 5.6 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmcl.2017.11.042
132404 119281 11 None -36 2 Human 6.1 pKi = 6.1 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 637 13 3 5 8.0 CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 10.1021/jm9504722
CHEMBL348126 119281 11 None -36 2 Human 6.1 pKi = 6.1 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 637 13 3 5 8.0 CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 10.1021/jm9504722
10161763 80315 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1021/jm0606185
CHEMBL215159 80315 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1021/jm0606185
10300357 141182 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 495 11 1 7 4.3 CCCCS(=O)(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL385714 141182 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 495 11 1 7 4.3 CCCCS(=O)(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
4189 205195 91 None -38 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 205195 91 None -38 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 205195 91 None -38 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
10182998 141352 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.7 CCCCS(=O)(=O)NC(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL386718 141352 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.7 CCCCS(=O)(=O)NC(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
132840 105010 18 None -3311 3 Rat 4.1 pKi = 4.1 Binding
In vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenalIn vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenal
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL312104 105010 18 None -3311 3 Rat 4.1 pKi = 4.1 Binding
In vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenalIn vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenal
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
11239632 99688 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 748 15 1 10 8.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4cccs4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL287829 99688 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 748 15 1 10 8.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4cccs4)cc3c2=O)cc1 10.1021/jm031031i
118725969 116697 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
CHEMBL3394209 116697 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
11251114 158640 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 714 14 2 9 7.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL409843 158640 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 714 14 2 9 7.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
73213179 104226 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 511 10 3 6 3.0 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1c(C)cc(C)cc1C 10.1016/j.bmcl.2013.12.040
CHEMBL3105465 104226 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 511 10 3 6 3.0 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1c(C)cc(C)cc1C 10.1016/j.bmcl.2013.12.040
10205901 82101 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 11 1 8 4.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCOC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217752 82101 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 11 1 8 4.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCOC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168294859 191678 0 None 19 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 13 1 6 7.3 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5205769 191678 0 None 19 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 13 1 6 7.3 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
44400615 156076 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1007 22 11 13 0.4 CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL406907 156076 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1007 22 11 13 0.4 CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
162670036 182074 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 517 8 1 8 5.0 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4788892 182074 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 517 8 1 8 5.0 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
168275495 189877 0 None 66 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 519 10 1 6 6.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5178838 189877 0 None 66 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 519 10 1 6 6.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
11672486 98059 0 None 3 2 Human 8.0 pKi = 8.0 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 994 25 12 12 0.3 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL276163 98059 0 None 3 2 Human 8.0 pKi = 8.0 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 994 25 12 12 0.3 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
166492458 190978 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 516 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5195051 190978 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 516 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
6918 1013 29 None -3 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2013.12.040
9804984 1013 29 None -3 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2013.12.040
CHEMBL189568 1013 29 None -3 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2013.12.040
73213180 104227 0 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 499 11 3 7 2.1 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(OC)cc1 10.1016/j.bmcl.2013.12.040
CHEMBL3105466 104227 0 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 499 11 3 7 2.1 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(OC)cc1 10.1016/j.bmcl.2013.12.040
73213252 104228 0 None - 1 Human 5.0 pKi = 5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 434 11 2 6 2.3 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)c1cccc(Cn2ccnc2)c1)[C@@H](C)CC 10.1016/j.bmcl.2013.12.040
CHEMBL3105467 104228 0 None - 1 Human 5.0 pKi = 5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 434 11 2 6 2.3 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)c1cccc(Cn2ccnc2)c1)[C@@H](C)CC 10.1016/j.bmcl.2013.12.040
1610 2315 89 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2315 89 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2315 89 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2315 89 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2315 89 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2315 89 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
1037 1548 65 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
3940 1548 65 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
5281037 1548 65 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
588 1548 65 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
CHEMBL813 1548 65 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
DB00876 1548 65 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
2583 3717 115 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
592 3717 115 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
65999 3717 115 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
CHEMBL1017 3717 115 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
DB00966 3717 115 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
16133225 415 47 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
172198 415 47 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
2504 415 47 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
45266664 415 47 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
5272 415 47 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
CHEMBL408403 415 47 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
DB11842 415 47 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
16133225 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
16133225 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
172198 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
172198 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
2504 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
2504 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
45266664 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
45266664 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
5272 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
5272 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
CHEMBL408403 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
CHEMBL408403 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
DB11842 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
DB11842 415 47 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
44299731 416 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
44299731 416 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8242249
585 416 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
585 416 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8242249
CHEMBL56448 416 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
CHEMBL56448 416 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8242249
123794 880 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
123794 880 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
3944 880 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
3944 880 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
594 880 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
594 880 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
CHEMBL1885579 880 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
CHEMBL1885579 880 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
5311345 2972 39 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 1709220
5311345 2972 39 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 2402226
597 2972 39 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 1709220
597 2972 39 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 2402226
CHEMBL321820 2972 39 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 1709220
CHEMBL321820 2972 39 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 2402226
595 2947 0 None - 1 Rat 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2194459
4189 205195 91 None -38 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1559 205195 91 None -38 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL91 205195 91 None -38 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
36736 3418 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
598 3418 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
6324663 3418 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
CHEMBL356431 3418 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
6893 2823 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18207609
9987879 2823 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18207609
6894 414 0 None -1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
91691124 414 0 None -1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
6918 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 15537354
9804984 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 15537354
CHEMBL189568 1013 29 None -3 3 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 15537354
11931 1048 0 None 10 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 621 10 1 8 6.7 CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
126456406 1048 0 None 10 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 621 10 1 8 6.7 CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
11930 1004 0 None 537 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
15780052 1004 0 None 537 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
CHEMBL289472 1004 0 None 537 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944