VU-1545


SMILES O=C(c1ccc(cc1)[N+](=O)[O-])Nc1cc(nn1c1ccccc1F)c1ccccc1
InChIKey BRAZLURTFMCAHU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 402.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 6.8 6.8 6.8 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 6.81 6.81 6.81 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pEC50 8.02 8.02 8.02 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pEC50 8.0 8.0 8.0 Guide to Pharmacology