L-AP4
| SMILES | OC(=O)[C@H](CCP(=O)(O)O)N |
| InChIKey | DDOQBQRIEWHWBT-VKHMYHEASA-N |
Chemical properties
| Hydrogen bond acceptors | 3 |
| Hydrogen bond donors | 4 |
| Rotatable bonds | 4 |
| Molecular weight (Da) | 183.0 |
Drug properties
| Molecular type | Small molecule |
| Endogenous/Surrogate | Surrogate |
| Approved drug | No |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu8 | GRM8 | Human | Metabotropic glutamate | C | pKd | 6.6 | 6.65 | 6.7 | Guide to Pharmacology |
| mGlu4 | GRM4 | Rat | Metabotropic glutamate | C | pKd | 6.3 | 6.3 | 6.3 | Guide to Pharmacology |
| mGlu8 | GRM8 | Rat | Metabotropic glutamate | C | pKi | 5.72 | 5.72 | 5.72 | ChEMBL |
| mGlu8 | GRM8 | Human | Metabotropic glutamate | C | pKi | 7.21 | 7.21 | 7.21 | ChEMBL |
| mGlu6 | GRM6 | Human | Metabotropic glutamate | C | pKi | 6.05 | 6.05 | 6.05 | ChEMBL |
| mGlu4 | GRM4 | Rat | Metabotropic glutamate | C | pKi | 6.8 | 6.8 | 6.8 | ChEMBL |
| mGlu4 | GRM4 | Human | Metabotropic glutamate | C | pKi | 6.04 | 6.39 | 6.8 | ChEMBL |
| mGlu7 | GRM7 | Human | Metabotropic glutamate | C | pKi | 3.7 | 3.7 | 3.7 | Guide to Pharmacology |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu4 | GRM4 | Human | Metabotropic glutamate | C | pEC50 | 6.5 | 6.5 | 6.5 | Guide to Pharmacology |
| mGlu6 | GRM6 | Human | Metabotropic glutamate | C | pEC50 | 6.7 | 7.0 | 7.3 | Guide to Pharmacology |
| mGlu8 | GRM8 | Human | Metabotropic glutamate | C | pIC50 | 7.0 | 7.1 | 7.2 | Guide to Pharmacology |
| mGlu8 | GRM8 | Rat | Metabotropic glutamate | C | pEC50 | 6.2 | 6.2 | 6.2 | Guide to Pharmacology |
| mGlu4 | GRM4 | Rat | Metabotropic glutamate | C | pIC50 | 6.0 | 6.2 | 6.4 | Guide to Pharmacology |
| mGlu8 | GRM8 | Mouse | Metabotropic glutamate | C | pEC50 | 6.4 | 6.4 | 6.4 | ChEMBL |
| mGlu6 | GRM6 | Rat | Metabotropic glutamate | C | pEC50 | 5.46 | 6.08 | 7.26 | ChEMBL |
| mGlu8 | GRM8 | Rat | Metabotropic glutamate | C | pEC50 | 6.52 | 6.89 | 7.22 | ChEMBL |
| mGlu7 | GRM7 | Human | Metabotropic glutamate | C | pEC50 | 3.73 | 3.73 | 3.73 | ChEMBL |
| mGlu8 | GRM8 | Human | Metabotropic glutamate | C | pEC50 | 6.25 | 6.64 | 7.22 | ChEMBL |
| mGlu6 | GRM6 | Human | Metabotropic glutamate | C | pEC50 | 5.62 | 6.29 | 7.26 | ChEMBL |
| mGlu4 | GRM4 | Rat | Metabotropic glutamate | C | pEC50 | 5.92 | 6.68 | 7.52 | ChEMBL |
| mGlu4 | GRM4 | Human | Metabotropic glutamate | C | pEC50 | 6.16 | 6.59 | 7.0 | ChEMBL |
| mGlu7 | GRM7 | Human | Metabotropic glutamate | C | pEC50 | 3.8 | 3.8 | 3.8 | Guide to Pharmacology |