JNJ-46281222


SMILES FC(c1c(ccn2c1nnc2CC1CC1)CN1CCC(CC1)c1ccccc1)(F)F
InChIKey LYDKDODJIBQNLK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 414.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations mGlu2

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 8.33 8.33 8.33 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKd 8.77 8.77 8.77 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKi 8.12 8.12 8.12 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 7.68 7.74 7.8 ChEMBL