CHEMBL492480


SMILES O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1
InChIKey LZWDVLLURPUKQS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 8
Molecular weight (Da) 467.3

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.42 8.42 8.42 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.02 7.02 7.02 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.44 6.44 6.44 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.02 7.02 7.02 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.42 8.42 8.42 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.44 6.44 6.44 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pEC50 6.31 6.31 6.31 ChEMBL