Structure information

US28

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7RKF

SPECIES

Human cytomegalovirus

RESOLUTION

4.000

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ABL5442

PUBLICATION DATE

Jan. 26, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Fractalkine F25 1.24x24 TM1 hydrophobic
Fractalkine T26 1.25x25 TM1 polar (hydrogen bond)
Fractalkine T26 1.25x25 TM1 Van der Waals
Fractalkine W89 2.60x60 TM2 aromatic (face-to-edge)
Fractalkine W89 2.60x60 TM2 Van der Waals
Fractalkine L93 2.64x64 TM2 Van der Waals
Fractalkine T108 3.29x29 TM3 Van der Waals
Fractalkine Y112 3.33x33 TM3 Van der Waals
Fractalkine Q172 ECL2 Van der Waals
Fractalkine M174 45.51x51 ECL2 Van der Waals
Fractalkine M174 45.51x51 ECL2 hydrophobic
Fractalkine D178 ECL2 polar (charge-assisted hydrogen bond)
Fractalkine L273 7.35x34 TM7 hydrophobic
Fractalkine L273 7.35x34 TM7 Van der Waals
Fractalkine I274 7.36x35 TM7 Van der Waals
Fractalkine I274 7.36x35 TM7 hydrophobic
Fractalkine E277 7.39x38 TM7 Van der Waals

Ligands

Fractalkine

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Residue Diagrams

F N G I S G F L F V V G Y L F L T V P K 1 I N L A A A D L L F V C T L P L W M Q Y 2 E T I F C L S A F M A V Y F C A T L L T 3 A C L F S I F W W I F A V I I A I P H 4 Y C Y S I V S L P I V F A G L M L E V N L 5 I A V V L V F I I F W L P Y H L T L F V 6 L P N L C C H C F A L S E T L I L A R 7
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ICL1 R R I Q ICL1ECL1 H N S L ECL1ICL2 M R Y R ICL2ECL2 V V T K K D N Q C M T D Y D Y L E V ECL2ICL3 Q S R ICL3ECL3 W I S S ECL3N-term M T P T T T T A E L T T E F D Y D E D A T P C V N-termC-term Q R L F S R D V S W Y H S M S F S R R S S P S R R E T S S D T L S D E V C R V S Q I I P C-term F T D V L N Q S K P V T L F L Y G V V F L F G S I G N F L V I F T I T W R C S G D V Y F I N L A A A D L L F V C T L P L W M Q Y L L D A S V P C T L L T A C F Y V A M F A S L C F I T E I A L D R Y Y A I V Y P V K Q A C L F S I F W W I F A V I I A I P H F M S Y P I I L N V E L M L G A F V I P L S V I S Y C Y Y R I S R I V A V S H K G R I V R V L I A V V L V F I I F W L P Y H L T L F V D T L K L L K S C E F E R S L K R A L I L T E S L A F C H C C L N P L L Y V F V G T K L H C F R F R Q E L L A E
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Residue Table


GPCRdb(A)
GPCRdb(A)
US28
TM1
1x24 1.24x24 F25
1x25 1.25x25 T26
TM2
2x60 2.60x60 W89
2x64 2.64x64 L93
TM3
3x29 3.29x29 T108
3x33 3.33x33 Y112
ECL2
45x51 45.51x51 M174
TM7
7x34 7.35x34 L273
7x35 7.36x35 I274
7x38 7.39x38 E277