Structure information

M5 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6OL9

SPECIES

Homo sapiens

RESOLUTION

2.540

PREFERRED CHAIN

A

PUBLICATION DATE

Dec. 11, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Tiotropium Y111 3.33x33 TM3 hydrophobic
Tiotropium A198 5.43x44 TM5 polar (hydrogen bond with backbone)
Tiotropium W455 6.48x48 TM6 aromatic (edge-to-face)
Tiotropium Y458 6.51x51 TM6 hydrophobic
Tiotropium N459 6.52x52 TM6 polar (hydrogen bond)
Tiotropium N459 6.52x52 TM6 polar (hydrogen bond)
Tiotropium N459 6.52x52 TM6 polar (hydrogen bond)
Tiotropium Y481 7.39x38 TM7 hydrophobic
Tiotropium C484 7.42x41 TM7 hydrophobic

Ligands

Tiotropium

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Residue Diagrams

V N G V I T I L S V V A T V A A I T I V 1 L S L A C A D L I I G F I S M N L Y T T Y 2 V L L N M V S A N S A V Y D L A L W L D 3 A G I M I G L A W L I S F I L W A P A I 4 Y L I T M V S V P I Y F A A I A T G F T I 5 S A I L L A F I I T W T P Y N I M V L V 6 I P N V T S N V Y C L W Y G L H W L T 7
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ICL1 S Q L K ICL1ECL1 R W A L ECL1ICL2 P L T Y R A K R ICL2ECL2 K R T V P L D E C Q I Q F L S ECL2ICL3 Q G S D S V T K A E K R K P A H R A L F R S C L R C P R P T L A Q R E R N Q A S W S S S R R S T S T T G K P S Q A T G P S A N W A K A E Q L T T C S S Y P S S E D E D K P A T D P V L Q V V Y K S Q G K E S P G E E F S A E E T E E T F V K A E T E K S D Y D T P N Y L L S P A A A H R P K S Q K C V A Y K F R L V V K A D G N Q E T N N G C H K V K I M P C P F P V A K E P S T K G L N P N P S H Q M T K R K ICL3ECL3 D K C V ECL3N-term M E G D S Y H N A T T V N G T P V N H Q P L E R H N-termC-term C R W K K K K V E E K L Y W Q G N S K L P C-term R L W E V I T I A A V T A V V S L I T I V G N V L V M I S F K V N T V N N Y Y L L S L A C A D L I I G I F S M N L Y T T Y I L M G G S L A C D L W L A L D Y V A S N A S V M N L L V I S F D R Y F S I T R T P K R A G I M I G L A W L I S F I L W A P A I L C W Q Y L V G E P T I T F G T A I A A F Y I P V S V M T I L Y C R I Y R E T E K R T K D L A D L R V V L V K E R K A A Q T L S A I L L A F I I T W T P Y N I M V L V S T F C P V T L W H L G Y W L C Y V N S T V N P I C Y A L C N R T F K M F R K T L L L
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Residue Table


GPCRdb(A)
GPCRdb(A)
M5 receptor
TM3
3x33 3.33x33 Y111
TM5
5x44 5.43x44 A198
TM6
6x48 6.48x48 W455
6x51 6.51x51 Y458
6x52 6.52x52 N459
TM7
7x38 7.39x38 Y481
7x41 7.42x41 C484