Structure information

FFA1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5TZR

SPECIES

Homo sapiens

RESOLUTION

2.200

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

June 7, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
MK-8666 P80 3.26x26 TM3 hydrophobic
MK-8666 A83 3.29x29 TM3 hydrophobic
MK-8666 V84 3.30x30 TM3 hydrophobic
MK-8666 F87 3.33x33 TM3 hydrophobic
MK-8666 Y91 3.37x37 TM3 polar (charge-assisted hydrogen bond)
MK-8666 L138 4.57x57 TM4 polar (hydrogen bond with backbone)
MK-8666 F142 4.61x61 TM4 aromatic (edge-to-face)
MK-8666 L158 ECL2 hydrophobic
MK-8666 W174 ECL2 hydrophobic
MK-8666 R183 5.39x40 TM5 polar (charge-charge)
MK-8666 Y2240 6.51x51 TM6 polar (charge-assisted hydrogen bond)
MK-8666 Y2240 6.51x51 TM6 polar (charge-assisted hydrogen bond)
MK-8666 R2258 7.35x34 TM7 polar (charge-charge)

Ligands

MK-8666

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Residue Diagrams

V N L P F G L A F A A V Y L G F S L Q P 1 L N L G C S D L L L T V S L P L K A V E 2 A A L F G G G A Y L P F F H A V A F V P 3 S W G V C A A I W A L V L C H L G L V F 4 Y C F A T I A L P L F F L L L S L S F R A 5 A G G A L L T L L L C V G P Y N A S N V A 6 L P N L V V S W A G T I L G L K R W S 7
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ICL1 L ICL1ECL1 G A W P L ECL1ICL2 P L G Y Q A F R ICL2ECL2 P G G W L D H S N T S L G I N T P V N G S P V C L E A W ECL2ICL3 S G L T H ICL3ECL3 P N L G ECL3N-term M D L N-termC-term G G K S Q K C-term P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A H A R L R T P S L V Y A L N L G C S D L L L T V S L P L K A V E A L A S P A S L C P V F A V A H F F P L Y A G G G F L A A L S A G R Y L G A A F R P C Y S W G V C A A I W A L V L C H L G L V F G L E A D P A S A G P A R F S L S L L L F F L P L A I T A F C Y V G C L R A L A R R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y G S W R K L G L I T G A W S V V L N P L V T G Y L G R G T V C Q P G L K A A R T
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Residue Table


GPCRdb(A)
GPCRdb(A)
FFA1 receptor
TM3
3x26 3.26x26 P80
3x29 3.29x29 A83
3x30 3.30x30 V84
3x33 3.33x33 F87
3x37 3.37x37 Y91
TM4
4x57 4.57x57 L138
4x61 4.61x61 F142
TM5
5x40 5.39x40 R183
TM6
6x51 6.51x51 Y240
TM7
7x34 7.35x34 R258