Structure information

CCR9

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5LWE

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

B

REFERENCE

10.1038/NATURE20606

PUBLICATION DATE

Dec. 7, 2016

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Vercirnon Y73 1.57x57 TM1 hydrophobic
Vercirnon R78 ICL1 polar (charge-assisted hydrogen bond)
Vercirnon T81 2.37x37 TM2 polar (hydrogen bond)
Vercirnon D84 2.40x40 TM2 polar (charge-assisted hydrogen bond)
Vercirnon L87 2.43x43 TM2 hydrophobic
Vercirnon I140 3.46x46 TM3 hydrophobic
Vercirnon A255 6.36x36 TM6 hydrophobic
Vercirnon V259 6.40x40 TM6 hydrophobic
Vercirnon Y317 7.53x53 TM7 aromatic (face-to-edge)
Vercirnon E322 8.48x48 H8 polar (hydrogen bond with backbone)
Vercirnon R323 8.49x49 H8 polar (charge-assisted hydrogen bond)
Vercirnon R323 8.49x49 H8 polar (hydrogen bond with backbone)
Vercirnon F324 8.50x50 H8 polar (hydrogen bond with backbone)

Ligands

Vercirnon

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Residue Diagrams

S N G L A G V I F V L W Y L P P L F H S 1 L N L A I A D L L F L V T L P F W A I A 2 C M I L L V C S Y F N M K Y M S N V V K 3 S K M V C F T I W V L A A A L C I P E 4 Y C C A M V V F P L F F G L I V K L T L V 5 I T V L T V F V L S Q F P Y N C I L L V 6 V P N L C S H F F A I T Q T V Q F C I 7
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ICL1 T R V K ICL1ECL1 Q W K F ECL1ICL2 A M R A H T W ICL2ECL2 Q I K E E S G I A I C T M V Y P S D E S T ECL2ICL3 K K ICL3ECL3 F I S ECL3N-term M T P T D F T S P I P N M A D D Y G S E S T S S M E D Y V N F N F T D F Y C E K N N N-termC-term Q W V S F T R R E G S L K L S S M L L E T T S G A L S L C-term V R Q F A S H F L P P L Y W L V F I V G A L G N S L V I L V Y W Y C T M T D M F L L N L A I A D L L F L V T L P F W A I A A A D Q T F M C K V V N S M Y K M N F Y S C V L L I M C I S V D R Y I A I A Q R E K R L L Y S K M V C F T I W V L A A A L C I P E I L Y S K L K S A V L T L K V I L G F F L P F V V M A C C Y T I I I H T L I Q A S S K H K A L K V T I T V L T V F V L S Q F P Y N C I L L V Q T I D A Y A M N C A V S T N I D I C F Q V T Q T I A F F H S C L N P V L Y V F V G E R L V K L G C F R R D T L K N I S Q A
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR9
TM1
1x57 1.57x57 Y73
TM2
2x37 2.37x37 T81
2x40 2.40x40 D84
2x43 2.43x43 L87
TM3
3x46 3.46x46 I140
TM6
6x36 6.36x36 V255
6x40 6.40x40 V259
TM7
7x53 7.53x53 Y317
H8
8x48 8.48x48 E322
8x49 8.49x49 R323
8x50 8.50x50 F324