Structure information

M2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4MQT

SPECIES

Homo sapiens

RESOLUTION

3.700

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE12735

PUBLICATION DATE

Nov. 27, 2013

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
LY2119620 Y80 2.61x60 TM2 polar (hydrogen bond)
LY2119620 Y80 2.61x60 TM2 Van der Waals
LY2119620 Y83 2.64x63 TM2 Van der Waals
LY2119620 Y83 2.64x63 TM2 hydrophobic
LY2119620 E172 ECL2 Van der Waals
LY2119620 Y177 45.51x51 ECL2 aromatic (face-to-face)
LY2119620 Y177 45.51x51 ECL2 Van der Waals
LY2119620 N410 6.58x58 TM6 Van der Waals
LY2119620 N410 6.58x58 TM6 polar (hydrogen bond)
LY2119620 A414 ECL3 Van der Waals
LY2119620 A414 ECL3 hydrophobic
LY2119620 N419 7.32x31 TM7 polar (hydrogen bond)
LY2119620 W422 7.35x34 TM7 Van der Waals
LY2119620 W422 7.35x34 TM7 aromatic (face-to-face)
LY2119620 T423 7.36x35 TM7 Van der Waals
LY2119620 Y426 7.39x38 TM7 Van der Waals

Ligands

LY2119620

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Residue Diagrams

I N G I I T V L S L S G A V L V I F V V 1 F S L A C A D L I I G F V S M N L Y T L Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G M M I A A A W V L S F I L W A P A I 4 Y L V T M I I V P L Y F A A I A T G F T V 5 L A I L L A F I I T W A P Y N V M V L I 6 A P N I T S N I Y C L W Y G I T W V T 7
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ICL1 R H L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P V K R ICL2ECL2 V R T V E D G E C Y I Q F F S ECL2ICL3 P V A N Q D P V S P S L V Q G R I V K P N N N N M P S S D D G L E H N K I Q N G K A P R D P V T E N C V Q G E E K E S S N D S T S V S A V A S N M R D D E I T Q D E N T V S T S L G H S K D E N S K Q T C I R I G T K T P K S D S C T P T N T T V E V V G S S G Q N G D E K Q N I V A R K I V K M T K Q P A K K ICL3ECL3 A P C I ECL3N-term M N N S T N S S N N S L A L T S P Y N-termC-term C H Y K N I G A T R C-term K T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K K D K K E K P P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K H F K K T L L M
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Residue Table


GPCRdb(A)
GPCRdb(A)
M2 receptor
TM2
2x60 2.61x60 Y80
2x63 2.64x63 Y83
ECL2
45x51 45.51x51 Y177
TM6
6x58 6.58x58 N410
TM7
7x31 7.32x31 N419
7x34 7.35x34 W422
7x35 7.36x35 T423
7x38 7.39x38 Y426