Arrestin Couplings




Source Receptor Log(Emax/EC50) pEC50 Emax
Cl RecFam
UniProt
GtP ARRB1 ARRB2 ARRB1 ARRB2 ARRB1 ARRB2
Bouvier A 5-Hydroxytryptamine 5HT1A 5-HT1A 4.93 5.45 6.58 6.64 2.22 6.49
Bouvier A 5-Hydroxytryptamine 5HT1B 5-HT1B 4.96 5.68 7.6 7.68 0.23 0.99
Bouvier A 5-Hydroxytryptamine 5HT1D 5-HT1D 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A 5-Hydroxytryptamine 5HT2A 5-HT2A 6.18 6.35 6.96 6.83 16.56 33.02
Bouvier A 5-Hydroxytryptamine 5HT2B 5-HT2B 6.49 7.14 7.81 8.17 4.81 9.4
Bouvier A 5-Hydroxytryptamine 5HT2C 5-HT2C 7.71 7.93 8.0 8.46 52.02 29.75
Bouvier A Acetylcholine (muscarinic) ACM1 M1 0.0 3.99 0.0 5.11 0.0 7.48
Bouvier A Acetylcholine (muscarinic) ACM2 M2 7.02 7.32 7.34 7.62 47.79 50.19
Bouvier A Acetylcholine (muscarinic) ACM3 M3 3.69 4.79 6.37 5.88 0.21 8.07
Bouvier A Acetylcholine (muscarinic) ACM4 M4 5.88 6.47 6.54 7.0 21.49 30.06
Bouvier A Adrenoceptors ADA1D α1D-adrenoceptor 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Adrenoceptors ADA2A α2A-adrenoceptor 5.56 5.79 6.23 6.35 21.34 28.03
Bouvier A Adrenoceptors ADA2B α2B-adrenoceptor 5.55 5.98 6.94 6.82 4.07 14.39
Bouvier A Adrenoceptors ADA2C α2C-adrenoceptor 4.7 6.11 6.11 7.13 3.9 9.57
Bouvier A Adrenoceptors ADRB1 β1-adrenoceptor 5.55 5.9 6.55 6.78 9.92 13.19
Bouvier A Adrenoceptors ADRB2 β2-adrenoceptor 3.52 4.86 4.42 5.31 12.56 35.72
Bouvier A Dopamine DRD1 D1 4.7 5.1 5.56 5.64 13.82 28.98
Bouvier A Dopamine DRD2 D2 5.58 6.07 7.13 7.17 2.8 7.9
Bouvier A Dopamine DRD5 D5 5.24 5.98 6.75 6.94 3.05 11.0
Bouvier A Histamine HRH1 H1 3.39 5.17 4.31 5.53 12.11 43.61
Bouvier A Histamine HRH2 H2 3.98 4.48 4.82 5.25 14.54 17.18
Bouvier A Angiotensin AGTR1 AT1 7.42 7.75 8.64 8.84 6.04 8.22
Bouvier A Apelin APJ apelin 7.65 7.76 8.82 8.96 6.77 6.26
Bouvier A Bradykinin BKRB1 B1 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Bradykinin BKRB2 B2 8.38 8.23 8.62 8.52 57.89 50.85
Bouvier A Cholecystokinin CCKAR CCK1 7.99 8.54 8.33 8.72 45.58 65.96
Bouvier A Complement peptide C5AR1 C5a1 7.77 7.67 7.77 7.67 100.0 100.0
Bouvier A Endothelin EDNRA ETA 7.51 8.22 8.23 8.38 18.94 68.67
Bouvier A Ghrelin GHSR ghrelin 6.37 7.29 8.25 8.52 1.32 5.95
Bouvier A Gonadotrophin-releasing hormone GNRHR GnRH1 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Melanocortin MC3R MC3 6.7 8.21 8.72 8.79 0.95 26.17
Bouvier A Melanocortin MC4R MC4 0.0 5.71 0.0 7.45 0.0 1.81
Bouvier A Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 6.98 7.18 7.98 7.77 9.92 25.62
Bouvier A Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 0.0 0.0 0.0 8.01 0.0 0.0
Bouvier A Neuropeptide Y NPY1R Y1 0.0 6.27 0.0 8.81 0.0 0.29
Bouvier A Neuropeptide Y NPY5R Y5 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Opioid OPRD δ 6.48 7.11 7.07 7.49 25.44 41.79
Bouvier A Opioid OPRK κ 7.15 7.34 8.36 8.39 6.16 8.76
Bouvier A Opioid OPRM μ 6.62 7.14 7.1 7.42 33.17 51.65
Bouvier A Opioid OPRX NOP 6.85 7.67 8.25 8.72 4.0 9.0
Bouvier A Orexin OX2R OX2 7.92 8.12 8.47 8.56 27.91 36.81
Bouvier A Proteinase-activated PAR1 PAR1 4.23 4.46 5.08 5.18 14.1 19.28
Bouvier A Proteinase-activated PAR2 PAR2 4.1 4.05 4.65 4.75 28.2 20.15
Bouvier A Somatostatin SSR2 SST2 8.8 8.82 8.81 8.92 96.2 79.29
Bouvier A Vasopressin and oxytocin V1AR V1A 7.21 7.43 7.74 7.82 29.18 39.95
Bouvier A Vasopressin and oxytocin V2R V2 6.64 6.97 7.6 7.85 10.98 13.27
Bouvier A Vasopressin and oxytocin OXYR OT 6.62 7.54 8.09 8.6 3.35 8.63
Bouvier A Chemokine CCR5 CCR5 7.7 7.96 8.18 8.26 32.86 50.85
Bouvier A Chemokine CCR6 CCR6 6.19 6.38 7.57 7.51 4.14 7.33
Bouvier A Chemokine CXCR2 CXCR2 8.28 7.57 8.64 8.18 43.45 24.84
Bouvier A Chemokine CXCR4 CXCR4 0.0 0.0 8.44 0.0 0.0 0.0
Bouvier A Chemokine CXCR5 CXCR5 6.5 6.75 6.86 7.0 44.02 56.05
Bouvier A Free fatty acid FFAR2 FFA2 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Free fatty acid FFAR3 FFA3 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Free fatty acid FFAR4 FFA4 4.25 4.5 4.7 4.87 35.89 42.81
Bouvier A Leukotriene LT4R1 BLT1 6.65 7.7 6.99 7.9 45.79 63.92
Bouvier A Leukotriene LT4R2 BLT2 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Leukotriene CLTR1 CysLT1 5.54 5.85 6.43 6.59 12.81 18.34
Bouvier A Leukotriene CLTR2 CysLT2 5.4 6.05 6.89 7.63 3.23 2.66
Bouvier A Lysophospholipid (LPA) LPAR1 LPA1 6.47 6.4 7.53 7.46 8.81 8.73
Bouvier A Lysophospholipid (LPA) LPAR2 LPA2 6.14 6.68 6.77 7.08 23.25 40.14
Bouvier A Lysophospholipid (S1P) S1PR1 S1P1 6.45 6.82 7.27 7.46 15.17 23.17
Bouvier A Cannabinoid CNR1 CB1 0.0 5.12 0.0 6.16 0.0 9.22
Bouvier A Cannabinoid CNR2 CB2 7.12 7.12 8.61 8.65 3.22 3.0
Bouvier A Prostanoid PE2R1 EP1 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Prostanoid PE2R2 EP2 4.94 5.38 6.51 6.92 2.65 2.88
Bouvier A Prostanoid PE2R3 EP3 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Prostanoid PE2R4 EP4 7.8 7.94 8.92 9.25 7.52 4.94
Bouvier A Prostanoid PF2R FP 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Melatonin MTR1A MT1 7.16 7.48 8.94 8.75 1.66 5.42
Bouvier A Melatonin MTR1B MT2 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Adenosine AA1R A1 0.0 4.4 0.0 6.34 0.0 1.16
Bouvier A Adenosine AA2AR A2A 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Adenosine AA2BR A2B 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Adenosine AA3R A3 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A P2Y P2RY2 P2Y2 3.96 3.78 5.24 5.36 5.26 2.63
Bouvier A Bile acid GPBAR GPBA 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A Hydroxycarboxylic acid HCAR2 HCA2 4.43 5.41 6.05 6.31 2.37 12.73
Bouvier A Hydroxycarboxylic acid HCAR3 HCA3 2.78 2.78 3.49 3.47 19.52 20.06
Bouvier A A orphans GPR4 GPR4 5.26 0.0 7.66 0.0 0.4 0.0
Bouvier A A orphans GPR39 GPR39 0.0 1.44 0.0 4.02 0.0 0.26
Bouvier A A orphans PSYR GPR65 3.95 0.0 5.98 0.0 0.95 0.0
Bouvier A A orphans OGR1 GPR68 4.45 4.76 6.25 6.07 1.58 4.94
Bouvier A A orphans GPR84 GPR84 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier A A orphans GP183 GPR183 8.51 8.17 8.95 8.8 36.8 23.87
Bouvier B1 Calcitonin CALCR CT 6.11 7.05 8.28 8.21 0.68 6.94
Bouvier B1 Corticotropin-releasing factor CRFR1 CRF1 6.34 6.07 7.39 6.77 8.93 19.85
Bouvier B1 Corticotropin-releasing factor CRFR2 CRF2 7.75 7.96 8.08 8.16 47.07 62.58
Bouvier B1 Glucagon GIPR GIP 5.5 7.03 7.38 8.4 1.31 4.31
Bouvier B1 Glucagon GLP1R GLP-1 7.58 8.05 8.33 8.46 17.89 39.66
Bouvier B1 Glucagon GLP2R GLP-2 8.06 8.07 8.77 8.6 19.54 29.32
Bouvier B1 Glucagon GLR glucagon 7.01 7.8 7.51 8.22 32.1 38.43
Bouvier B1 Parathyroid hormone PTH1R PTH1 8.7 8.59 8.74 8.76 90.98 68.85
Bouvier B1 VIP and PACAP VIPR1 VPAC1 8.77 8.91 9.11 9.25 45.34 45.52
Bouvier C Metabotropic glutamate GRM2 mGlu2 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier C Metabotropic glutamate GRM4 mGlu4 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier C Metabotropic glutamate GRM5 mGlu5 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier C Metabotropic glutamate GRM6 mGlu6 0.0 0.0 0.0 0.0 0.0 0.0
Bouvier C Metabotropic glutamate GRM8 mGlu8 0.0 0.0 0.0 0.0 0.0 0.0