GPBA receptor (gpbar_human)

FAMILY

Class A (Rhodopsin) Steroid receptors Bile acid receptors GPBA receptor

GENE

GPBAR1 (TGR5)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
T
P
N
S
T
G
E
V
P
10
      TM1        
S
P
I
P
K
G
A
L
G
L
20
                   
S
L
A
L
A
S
L
I
I
T
30
                   
A
N
L
L
L
A
L
G
I
A
40
    ICL1 TM2  
W
D
R
R
L
R
S
P
P
A
50
                   
G
C
F
F
L
S
L
L
L
A
60
                   
G
L
L
T
G
L
A
L
P
T
70
        ECL1    
L
P
G
L
W
N
Q
S
R
R
80
TM3              
G
Y
W
S
C
L
L
V
Y
L
90
                   
A
P
N
F
S
F
L
S
L
L
100
                   
A
N
L
L
L
V
H
G
E
R
110
            ICL2
Y
M
A
V
L
R
P
L
Q
P
120
    TM4          
P
G
S
I
R
L
A
L
L
L
130
                   
T
W
A
G
P
L
L
F
A
S
140
          ECL2  
L
P
A
L
G
W
N
H
W
T
150
                   
P
G
A
N
C
S
S
Q
A
I
160
  TM5            
F
P
A
P
Y
L
Y
L
E
V
170
                   
Y
G
L
L
L
P
A
V
G
A
180
                   
A
A
F
L
S
V
R
V
L
A
190
                   
T
A
H
R
Q
L
Q
D
I
C
200
                   
R
L
E
R
A
V
C
R
D
E
210
ICL3 TM6      
P
S
A
L
A
R
A
L
T
W
220
                   
R
Q
A
R
A
Q
A
G
A
M
230
                   
L
L
F
G
L
C
W
G
P
Y
240
                   
V
A
T
L
L
L
S
V
L
A
250
      ECL3 TM7
Y
E
Q
R
P
P
L
G
P
G
260
                   
T
L
L
S
L
L
S
L
G
S
270
                   
A
S
A
A
A
V
P
V
A
M
280
      H8          
G
L
G
D
Q
R
Y
T
A
P
290
                   
W
R
A
A
A
Q
R
C
L
Q
300
C-term        
G
L
W
G
R
A
S
R
D
S
310
                   
P
G
P
S
I
A
Y
H
P
S
320
                   
S
Q
S
S
V
D
L
D
L
N
330

LINKS

DIAGRAMS

L N A T I I L S A L A L S L G L A G K P 1 L S L L L A G L L T G L A L P T L P G L 2 L L L N A L L S L F S F N P A L Y V L L 3 I R L A L L L T W A G P L L F A S L P A 4 L F A A A G V A P L L L G Y V E L Y L Y P 5 A G A M L L F G L C W G P Y V A T L L L 6 V P V A A A S A S G L S L L S L L T G 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

ICL1 R R L R ICL1ECL1 W N Q S R R ECL1ICL2 P L Q P P G ICL2ECL2 W N H W T P G A N C S S Q A I F ECL2ICL3 R D E P ICL3ECL3 R P P L ECL3N-term M T P N S T G E V P S P I N-termC-term R C L Q G L W G R A S R D S P G P S I A Y H P S S Q S S V D L D L N C-term P K G A L G L S L A L A S L I I T A N L L L A L G I A W D S P P A G C F F L S L L L A G L L T G L A L P T L P G L G Y W S C L L V Y L A P N F S F L S L L A N L L L V H G E R Y M A V L R S I R L A L L L T W A G P L L F A S L P A L G P A P Y L Y L E V Y G L L L P A V G A A A F L S V R V L A T A H R Q L Q D I C R L E R A V C S A L A R A L T W R Q A R A Q A G A M L L F G L C W G P Y V A T L L L S V L A Y E Q G P G T L L S L L S L G S A S A A A V P V A M G L G D Q R W R A Y T A P A A Q
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

chenodeoxycholic acid,

cholic acid,

deoxycholic acid,

lithocholic acid

HOMOLOGY MODELS

STRUCTURES

View in Structures