Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
oprd_mouse 3.33x33 129 TM3 Y => F N/A N/A Befort K et al (1999)
oprd_mouse 353 C-term T => A N/A N/A Trapaidze N et al (1996)
oprd_mouse 352 C-term T => A N/A N/A Trapaidze N et al (1996)
oprd_mouse 7.43x42 308 TM7 Y => F N/A N/A Befort K et al (1996)
oprd_mouse 361 C-term T => A N/A N/A Trapaidze N et al (2000)
oprd_mouse 5.47x47 222 TM5 F => A N/A N/A Befort K et al (1996)
oprd_mouse 358 C-term T => A N/A N/A Trapaidze N et al (2000)
oprd_mouse 353 C-term T => A N/A N/A Xiang B et al (2001)
oprd_mouse 344 C-term S => G N/A N/A Trapaidze N et al (1996)
oprd_mouse 5.43x44 218 TM5 F => A N/A N/A Befort K et al (1996)
oprd_mouse 7.43x42 308 TM7 Y => F N/A N/A Befort K et al (1996)
oprd_mouse 363 C-term S => D N/A N/A Guo J et al (2000)
oprd_mouse 363 C-term S => A N/A N/A Guo J et al (2000)
oprd_mouse 353 C-term T => A N/A N/A Cvejic S et al (1996)
oprd_mouse 353 C-term T => A N/A N/A Trapaidze N et al (1996)
oprd_mouse 358 C-term T => A N/A N/A Xiang B et al (2001)
oprd_mouse 3.32x32 128 TM3 D => N N/A N/A Befort K et al (1999)
oprd_mouse 352 C-term T => A N/A N/A Guo J et al (2000)
oprd_mouse 7.43x42 308 TM7 Y => F N/A N/A Befort K et al (1999)
oprd_mouse 361 C-term T => A N/A N/A Xiang B et al (2001)
oprd_mouse 6.48x48 274 TM6 W => A N/A N/A Befort K et al (1996)
oprd_mouse 363 C-term S => G N/A N/A Guo J et al (2000)
oprd_mouse 7.43x42 308 TM7 Y => A N/A N/A Befort K et al (1996)
oprd_mouse 344 C-term S => G N/A N/A Cvejic S et al (1996)
oprd_mouse 4.50x50 173 TM4 W => A N/A N/A Befort K et al (1996)
oprd_mouse 6.48x48 274 TM6 W => A N/A N/A Befort K et al (1996)
oprd_mouse 344 C-term S => A N/A N/A Trapaidze N et al (1996)
oprd_mouse 4.50x50 173 TM4 W => A N/A N/A Befort K et al (1996)
oprd_mouse 5.43x44 218 TM5 F => A N/A N/A Befort K et al (1996)
oprd_mouse 3.33x33 129 TM3 Y => A N/A N/A Befort K et al (1996)
oprd_mouse 3.33x33 129 TM3 Y => F N/A N/A Befort K et al (1996)
oprd_mouse 361 C-term T => A N/A N/A Li J et al (2003)
oprd_mouse 2.50x50 95 TM2 D => N N/A N/A Kong H et al (1993)
oprd_mouse 352 C-term T => A N/A N/A Cvejic S et al (1996)
oprd_mouse 2.50x50 95 TM2 D => N N/A N/A Kong H et al (1993)
oprd_mouse 352 C-term T => A N/A N/A Xiang B et al (2001)
oprd_mouse 352 C-term T => A N/A N/A Cvejic S et al (1996)
oprd_mouse 361 C-term T => A N/A N/A Guo J et al (2000)
oprd_mouse 344 C-term S => G N/A N/A Guo J et al (2000)
oprd_mouse 358 C-term T => A N/A N/A Trapaidze N et al (1996)
oprd_mouse 363 C-term S => G N/A N/A Li J et al (2003)
oprd_mouse 355 C-term E => Q N/A N/A Li J et al (2003)
oprd_mouse 344 C-term S => D N/A N/A Xiang B et al (2001)
oprd_mouse 3.33x33 129 TM3 Y => A N/A N/A Befort K et al (1996)
oprd_mouse 344 C-term S => G N/A N/A Cvejic S et al (1996)
oprd_mouse 363 C-term S => G N/A N/A Xiang B et al (2001)
oprd_mouse 361 C-term T => A N/A N/A Trapaidze N et al (1996)
oprd_mouse 363 C-term S => D N/A N/A Xiang B et al (2001)
oprd_mouse 3.33x33 129 TM3 Y => A N/A N/A Befort K et al (1999)
oprd_mouse 2.50x50 95 TM2 D => N N/A N/A Bot G et al (1998)
oprd_mouse 3.32x32 128 TM3 D => N N/A N/A Befort K et al (1996)
oprd_mouse 353 C-term T => A N/A N/A Kovoor A et al (1997)
oprd_mouse 353 C-term T => E N/A N/A Trapaidze N et al (2000)
oprd_mouse 353 C-term T => A N/A N/A Trapaidze N et al (2000)
oprd_mouse 352 C-term T => A N/A N/A Trapaidze N et al (2000)
oprd_mouse 5.47x47 222 TM5 F => A N/A N/A Befort K et al (1996)
oprd_mouse 3.32x32 128 TM3 D => A N/A N/A Befort K et al (1996)
oprd_mouse 352 C-term T => A N/A N/A Trapaidze N et al (1996)
oprd_mouse 358 C-term T => A N/A N/A Guo J et al (2000)
oprd_mouse 344 C-term S => G N/A N/A Trapaidze N et al (1996)
oprd_mouse 353 C-term T => A N/A N/A Cvejic S et al (1996)
oprd_mouse 364 C-term D => N N/A N/A Li J et al (2003)
oprd_mouse 3.32x32 128 TM3 D => N N/A N/A Befort K et al (1996)
oprd_mouse 363 C-term S => A N/A N/A Trapaidze N et al (2000)
oprd_mouse 358 C-term T => A N/A N/A Li J et al (2003)
oprd_mouse 361 C-term T => D N/A N/A Guo J et al (2000)
oprd_mouse 363 C-term S => A N/A N/A Trapaidze N et al (1996)
oprd_mouse 361 C-term T => D N/A N/A Xiang B et al (2001)
oprd_mouse 358 C-term T => A N/A N/A Trapaidze N et al (1996)
oprd_mouse 3.32x32 128 TM3 D => N N/A N/A Bot G et al (1997)
oprd_mouse 358 C-term T => D N/A N/A Xiang B et al (2001)
oprd_mouse 358 C-term T => D N/A N/A Guo J et al (2000)
oprd_mouse 6.58x58 284 TM6 W => K N/A N/A Chaturvedi K et al (2000)
oprd_mouse 353 C-term T => A N/A N/A Guo J et al (2000)
oprd_mouse 344 C-term S => A N/A N/A Xiang B et al (2001)
oprd_mouse 4.54x54 177 TM4 S => L N/A N/A Claude PA et al (1996)
oprd_mouse 3.32x32 128 TM3 D => N N/A N/A Bot G et al (1998)
oprd_mouse 3.32x32 128 TM3 D => A N/A N/A Befort K et al (1999)
oprd_mouse 344 C-term S => G N/A N/A Xiang B et al (2001)
oprd_mouse 3.33x33 129 TM3 Y => F N/A N/A Befort K et al (1996)
oprd_mouse 363 C-term S => A N/A N/A Trapaidze N et al (1996)
oprd_mouse 361 C-term T => A N/A N/A Trapaidze N et al (1996)


Residue

Diagrams

ICL1 T K L K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 V T Q P R D G A V V C M L Q F P S ECL2ICL3 R L L S G ICL3ECL3 D I N R R ECL3N-term M E L V P S A R A E L Q S S P L V N L S D A F P S A F P S A G A N A S G S P G A N-termC-term P C G R Q E P G S L R R P R Q A T T R E R V T A C T P S D G P G G G A A A C-term R S A S S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P A K A K L I N I C I W V L A S G V G V P I M V M A P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F R Q F K R C L C R T
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
V N G L L G V A C V A S Y L A T I A I A 1 F N L A L A D A L A T S T L P F Q S A K 2 M T L T F I S T F M N Y Y D I S L V A K 3 A K L I N I C I W V L A S G V G V P I M 4 Y C V T I I L I P V V F A F L F V C I K T 5 L V V V G A F V V C W A P I H I F V I V 6 V P N L S S N A Y G L A I C L H L A A 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
δ receptor
TM2
2x50 2.50x50 D95
TM3
3x32 3.32x32 D128
3x33 3.33x33 Y129
TM4
4x50 4.50x50 W173
4x54 4.54x54 S177
TM5
5x44 5.43x44 F218
5x47 5.47x47 F222
TM6
6x48 6.48x48 W274
6x58 6.58x58 W284
TM7
7x42 7.43x42 Y308