Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
mtr1a_human 5.46x461 195 TM5 H => A N/A N/A Kokkola T et al (2003)
mtr1a_human 6 N-term S => K N/A N/A Hu ZW et al (1999)
mtr1a_human 7.38x37 280 TM7 S => A N/A N/A Kokkola T et al (2003)
mtr1a_human 3.49x49 124 TM3 N => L N/A N/A Kokkola T et al (2003)
mtr1a_human 5.43x44 192 TM5 V => A N/A N/A Kokkola T et al (2003)
mtr1a_human 7.38x37 280 TM7 S => F N/A N/A Kokkola T et al (2003)
mtr1a_human 6.50x50 253 TM6 P => A N/A N/A Kokkola T et al (2003)
mtr1a_human 3.49x49 124 TM3 N => D N/A N/A Nelson CS et al (2001)
mtr1a_human 7.38x37 280 TM7 S => A N/A N/A Kokkola T et al (1998)
mtr1a_human 3.49x49 124 TM3 N => D N/A N/A Kokkola T et al (2003)
mtr1a_human 1.59x59 54 TM1 R => W N/A N/A Ebisawa T et al (1999)
mtr1a_human 3.49x49 124 TM3 N => A N/A N/A Nelson CS et al (2001)
mtr1a_human 7.42x41 284 TM7 A => G N/A N/A Kokkola T et al (2003)
mtr1a_human 4.55x55 157 TM4 A => V N/A N/A Ebisawa T et al (1999)
mtr1a_human 5.46x461 195 TM5 H => A N/A N/A Kokkola T et al (1998)
mtr1a_human 5.43x44 192 TM5 V => T N/A N/A Kokkola T et al (2003)
mtr1a_human 3.49x49 124 TM3 N => K N/A N/A Kokkola T et al (2003)
mtr1a_human 3.32x32 107 TM3 M => T N/A N/A Kokkola T et al (1998)
mtr1a_human 3.49x49 124 TM3 N => E N/A N/A Kokkola T et al (2003)
mtr1a_human 3.32x32 107 TM3 M => D N/A N/A Kokkola T et al (2003)
mtr1a_human 7.37x36 279 TM7 A => S N/A N/A Kokkola T et al (2003)
mtr1a_human 3.49x49 124 TM3 N => K N/A N/A Nelson CS et al (2001)
mtr1a_human 6.50x50 253 TM6 P => A N/A N/A Kokkola T et al (1998)
mtr1a_human 3.49x49 124 TM3 N => L N/A N/A Nelson CS et al (2001)
mtr1a_human 3.55x55 130 TM3 C => S N/A N/A Kokkola T et al (2005)
mtr1a_human 1.59x59 54 TM1 R => W N/A N/A Ebisawa T et al (1999)
mtr1a_human 3.49x49 124 TM3 N => A N/A N/A Kokkola T et al (2003)
mtr1a_human 3.49x49 124 TM3 N => A N/A N/A Kokkola T et al (1998)
mtr1a_human 3.49x49 124 TM3 N => E N/A N/A Nelson CS et al (2001)
mtr1a_human 3.52x52 127 TM3 C => S N/A N/A Kokkola T et al (2005)
mtr1a_human 3.32x32 107 TM3 M => T N/A N/A Kokkola T et al (2003)
mtr1a_human 3.32x32 107 TM3 M => D N/A N/A Kokkola T et al (1998)
mtr1a_human 4.55x55 157 TM4 A => V N/A N/A Ebisawa T et al (1999)
mtr1a_human 5.46x461 195 TM5 H => A N/A N/A Kokkola T et al (1998)
mtr1a_human 3.49x49 124 TM3 N => A N/A N/A Kokkola T et al (1998)


Residue

Diagrams

ICL1 K K L R ICL1ECL1 G W N L ECL1ICL2 S L K Y D K L Y ICL2ECL2 T L Q Y D P R I Y S C T F A Q S V ECL2ICL3 K P D R K ICL3ECL3 P A S M V P R I ECL3N-term M Q G N G S A L P N A S Q P V L R G D G A R N-termC-term A R V F F V D S S N D V A D R V K W K P S P L M T N N N V V K V D S V C-term P S W L A S A L A C V L I F T I V V D I L G N L L V I L S V Y R N N A G N I F V V S L A V A D L V V A I Y P Y P L V L M S I F N N G Y L H C Q V S G F L M G L S V I G S I F N I T G I A I N R Y C Y I C H S S K N S L C Y V L L I W L L T L A A V L P N L R A G S S A Y T I A V V V F H F L V P M I I V I F C Y L R I W I L V L Q V R Q R V P K L K P Q D F R N F V T M F V V F V L F A I C W A P L N F I G L A V A S D P E W L F V A S Y Y M A Y F N S C L N A I I Y G L L N Q N Y R R L C T F R K E I I V S
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L N G L I D V V I T F I L V C A L A S A 1 V S L A V A D L V V A Y I P Y P L V L M S 2 G T I N F I S G I V S L G M L F G S V Q 3 S L C Y V L L I W L L T L A A V L P N 4 Y C F I V I I M P V L F H F V V V A I T Y 5 F V V F V L F A I C W A P L N F I G L A 6 I A N L C S N F Y A M Y Y S A V F L W 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
MT1 receptor
TM1
1x59 1.59x59 R54
TM3
3x32 3.32x32 M107
3x49 3.49x49 N124
3x52 3.52x52 C127
3x55 3.55x55 C130
TM4
4x55 4.55x55 A157
TM5
5x44 5.43x44 V192
5x461 5.46x461 H195
TM6
6x50 6.50x50 P253
TM7
7x36 7.37x36 A279
7x37 7.38x37 S280
7x41 7.42x41 A284