Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
glr_human 7.46x45 389 TM7 S => T 1.605↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.31x30 374 TM7 Q => R 1.438↓ EC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 2.67x67 194 TM2 I => K Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 369 ECL3 T => M 1.25↑ IC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 6.53x53 362 TM6 E => A 6.65↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.44x43 387 TM7 F => S 2.34↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 1.29x29 131 TM1 Q => R 1.49↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 211 ECL1 S => C 6.31↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 90 N-term K => C 316.228↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 3.37x37 232 TM3 Q => A 7.415↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 207 ECL1 G => C 1.585↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 64 N-term K => E Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 1.30x30 132 TM1 K => S 1.333↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 2.74x74 201 TM2 R => A 6.59↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 5.40x40 308 TM5 R => A 4.405↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 1.33x33 135 TM1 A => P Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 7.43x42 386 TM7 L => F Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.42x41 385 TM7 D => E 1.095↓ IC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 369 ECL3 T => M 1.786↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 215 ECL1 W => L Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.36x36 231 TM3 M => T Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 1.42x42 144 TM1 M => I 1.852↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 6.55x55 364 TM6 V => I 3.312↓ EC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 5.36x37 304 TM5 W => L 4.65↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 5.36x37 304 TM5 W => Q Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 302 ECL2 G => N 1.69↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.57x57 184 TM2 F => A 1.047↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 6.51x51 360 TM6 V => T 1.105↑ IC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 1.30x30 132 TM1 K => S 1.333↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 6.52x52 361 TM6 H => A 2.185↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 2.71x71 198 TM2 L => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 217 ECL1 S => C 31.623↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 128 N-term I => Q 1.481↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 1.39x39 141 TM1 F => L 1.07↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.73x73 200 TM2 T => W 1.942↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 6.37x37 346 TM6 R => E 15.849↓ pK(b) (Functional - cAMP accumulation) Mk-0893 Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 45.51x51 295 ECL2 W => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.41x40 384 TM7 F => T 3.58↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 297 ECL2 S => A 1.14↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 2.57x57 184 TM2 F => A 1.047↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 40 N-term G => S 3.107↓ K(d) (Binding - Radioligand saturation) glucagon Hansen LH et al (1996) 10.5281/zenodo.60790
glr_human 6.40x40 349 TM6 K => M 1.995↓ pK(d) (Binding - Radioligand saturation) Mk-0893 Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 1.47x47 149 TM1 Y => H 6.4↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 300 ECL2 N => A 5.45↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 5.37x38 305 TM5 W => A 3.655↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 208 ECL1 D => R 5.04↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 6.41x41 350 TM6 S => A 1.072↓ pK(d) (Binding - Radioligand saturation) Mk-0893 Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 71 N-term T => C 31.623↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 6.56x56 365 TM6 F => A 3.385↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.44x44 239 TM3 Y => A 1.03↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 1.47x47 149 TM1 Y => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 45 N-term H => C 100.0↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 1.38x38 140 TM1 S => F 1.43↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.46x45 389 TM7 S => T 1.605↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 40 N-term G => S N/A N/A Tonolo G et al (1997)
glr_human 7.40x39 383 TM7 F => A 3.175↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 123 N-term M => E 1.025↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.42x41 385 TM7 D => N 8.5↓ IC50 (Binding - Radioligand competition/displacement) glucagon Yang D et al (2016) Yang D et al (2016)
glr_human 369 ECL3 T => M 1.342↑ EC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 1.41x41 143 TM1 V => I 1.25↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.60x60 187 TM2 K => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 205 ECL1 K => A 1.325↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 5.36x37 304 TM5 W => Q Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 129 N-term E => R 1.639↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.33x33 228 TM3 A => V 2.84↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 205 ECL1 K => A 1.325↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 5.43x43 311 TM5 V => I Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 123 N-term M => E 1.025↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 116 N-term R => L Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 1.44x44 146 TM1 T => A N/A IC50 (Binding - Radioligand competition/displacement) glucagon Yang D et al (2016) Yang D et al (2016)
glr_human 1.36x36 138 TM1 Y => L 1.575↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 125 N-term G => K 1.25↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 2.73x73 200 TM2 T => C 10.0↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 116 N-term R => L Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 30 N-term D => L 1.176↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.44x44 171 TM2 C => S 31.623↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 45.51x51 295 ECL2 W => H Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.43x42 386 TM7 L => F Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.67x67 194 TM2 I => A 1.227↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 31 N-term F => W 1.515↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.62x62 189 TM2 S => L 1.361↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.31x30 374 TM7 Q => R N/A N/A Runge S et al (2003)
glr_human 7.37x36 380 TM7 A => I 1.267↓ IC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 40 N-term G => S N/A N/A Strazzullo P et al (2001)
glr_human 6.40x40 349 TM6 K => A 6.31↓ pK(b) (Functional - cAMP accumulation) Mk-0893 Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 40 N-term G => S N/A N/A Hansen LH et al (1996)
glr_human 7.42x41 385 TM7 D => E 1.062↓ IC50 (Binding - Radioligand competition/displacement) glucagon-(Gln9Glu) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 2.64x64 191 TM2 V => A 5.355↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 1.51x51 153 TM1 L => F Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 2.71x71 198 TM2 L => C 125.893↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 113 N-term Q => E 4.0↓ EC50 (Functional - cAMP accumulation) glucagon Koth CM et al (2012) Hollenstein K et al (2014)
glr_human 7.41x40 384 TM7 F => T 1.616↑ IC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 63 N-term D => R Abolished effect pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 3.43x43 238 TM3 N => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.74x74 201 TM2 R => M 2.5↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.41x40 384 TM7 F => T 2.141↑ IC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 3.36x36 231 TM3 M => A 1.036↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.37x37 232 TM3 Q => H 1.315↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 1.52x52 154 TM1 G => S 1.03↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.75x75 202 TM2 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.43x42 386 TM7 L => I 3.2↓ IC50 (Binding - Radioligand competition/displacement) glucagon Yang D et al (2016) Yang D et al (2016)
glr_human 2.60x60 187 TM2 K => Q Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 1.41x41 143 TM1 V => I 1.25↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 6.56x56 365 TM6 F => A 3.385↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.44x44 239 TM3 Y => A 1.03↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.27x27 222 TM3 A => C 1.585↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 45.51x51 295 ECL2 W => L 1.405↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 6.53x53 362 TM6 E => D Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 4.64x64 286 TM4 K => L Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 5.36x37 304 TM5 W => A 14.035↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 206 ECL1 I => C 50.119↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 2.71x71 198 TM2 L => V 2.82↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 208 ECL1 D => Q Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 120 N-term Q => C 1000.0↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 209 ECL1 D => Q 1.19↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 204 ECL1 Q => C 12.589↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 54 N-term T => C 63.096↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 40 N-term G => S 3.984↑ pEC50 (Functional - cAMP accumulation) glucagon Hansen LH et al (1996) 10.5281/zenodo.60790
glr_human 7.31x30 374 TM7 Q => R 1.46↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 40 N-term G => S N/A N/A Shiota D et al (2002)
glr_human 7.42x41 385 TM7 D => E >3.226↓ EC50 (Binding - Radioligand competition/displacement) glucagon-(Lys19Ser) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 4.64x64 286 TM4 K => L Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 5.37x38 305 TM5 W => A 3.655↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.35x34 378 TM7 R => A 6.475↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 40 N-term G => S N/A N/A Brand E et al (1999)
glr_human 45.50x50 294 ECL2 C => S Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.40x39 383 TM7 F => A 3.175↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 4.60x60 282 TM4 W => H Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 45.50x50 294 ECL2 C => S Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.31x30 374 TM7 Q => R 1.499↑ IC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 205 ECL1 K => C 1.996↑ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 4.65x65 287 TM4 C => S 1.0 pEC50 (Functional - cAMP accumulation) glucagon Yang D et al (2016) Hollenstein K et al (2014)
glr_human 7.41x40 384 TM7 F => T N/A N/A Runge S et al (2003)
glr_human 217 ECL1 S => A 1.07↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.33x33 228 TM3 A => F 2.335↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.36x35 379 TM7 S => F 1.312↓ EC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 204 ECL1 Q => T 1.183↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.41x40 384 TM7 F => T 3.75↓ EC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 7.37x36 380 TM7 A => I 1.562↓ EC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 218 ECL1 D => C 39.811↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 6.56x56 365 TM6 F => I 27.5↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.38x38 233 TM3 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 63 N-term D => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 1.51x51 153 TM1 L => F Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 122 N-term Q => A 1.38↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 61 N-term T => C 398.107↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 299 ECL2 D => S 1.435↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 40 N-term G => S N/A N/A Ambrosch A et al (1999)
glr_human 6.40x40 349 TM6 K => A 1.096↓ pK(i) (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 372 ECL3 H => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Yang D et al (2016) Yang D et al (2016)
glr_human 122 N-term Q => E 1.342↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.43x42 386 TM7 L => A 9.125↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.39x38 382 TM7 L => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 297 ECL2 S => R 1.57↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.42x41 385 TM7 D => E 8.818↓ EC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 8.47x47 404 H8 N => A 1.096↓ pK(i) (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 111 N-term R => C 398.107↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 2.57x57 184 TM2 F => A 35.385↓ IC50 (Binding - Radioligand competition/displacement) L168,049 Cascieri MA et al (1999) Hollenstein K et al (2014)
glr_human 6.37x37 346 TM6 R => A 1.096↓ pK(i) (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 8.47x47 404 H8 N => A Abolished effect pK(d) (Binding - Radioligand saturation) Mk-0893 Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 3.45x45 240 TM3 C => S 1.585↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 6.51x51 360 TM6 V => T 1.0 EC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 298 ECL2 N => Q 10.55↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.41x41 236 TM3 V => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 50 N-term L => C 316.228↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 300 ECL2 N => A 5.45↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.33x33 228 TM3 A => F 2.335↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 45.51x51 295 ECL2 W => L 1.405↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 6.51x51 360 TM6 V => T 1.5↓ EC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 2.64x64 191 TM2 V => A 5.355↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 6.39x39 348 TM6 A => N N/A N/A Sydow S et al (1999)
glr_human 3.26x26 221 TM3 V => C 2.512↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 3.40x40 235 TM3 I => V 1.08↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.75x75 202 TM2 Y => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.37x37 232 TM3 Q => A 7.415↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 6.37x37 346 TM6 R => A 2.188↓ pK(d) (Binding - Radioligand saturation) Mk-0893 Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 2.57x57 184 TM2 F => A N/A N/A Cascieri MA et al (1999)
glr_human 1.48x48 150 TM1 S => A 1.379↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 212 ECL1 V => W 2.353↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.30x30 225 TM3 R => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 2.74x74 201 TM2 R => M 2.5↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 1.31x31 133 TM1 E => P 2.955↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 45.51x51 295 ECL2 W => F 1.45↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 63 N-term D => A Abolished effect Single-point (Functional - cAMP accumulation) glucagon Zhao LH et al (2016) 10.5281/zenodo.60790
glr_human 40 N-term G => S N/A N/A Kahn CR et al (1996)
glr_human 113 N-term Q => N No effect EC50 (Functional - cAMP accumulation) glucagon Koth CM et al (2012) Hollenstein K et al (2014)
glr_human 2.60x60 187 TM2 K => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.25x25 220 TM3 A => C 50.119↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 6.56x56 365 TM6 F => I 27.5↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.65x65 192 TM2 L => F Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.37x37 232 TM3 Q => L Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 219 ECL1 G => C 79.433↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 298 ECL2 N => D 4.12↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 36 N-term W => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 45.50x50 294 ECL2 C => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.30x30 225 TM3 R => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.58x58 401 TM7 C => S 3.981↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 2.68x68 195 TM2 D => N 5.555↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 40 N-term G => S N/A N/A Huang X et al (1995)
glr_human 86 N-term P => S Abolished effect Single-point (Functional - cAMP accumulation) glucagon Zhao LH et al (2016) 10.5281/zenodo.60790
glr_human 45.51x51 295 ECL2 W => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 45.50x50 294 ECL2 C => S 3.984↑ pEC50 (Functional - cAMP accumulation) glucagon Yang D et al (2016) Hollenstein K et al (2014)
glr_human 1.36x36 138 TM1 Y => L 1.575↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 126 N-term E => R 1.942↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 1.42x42 144 TM1 M => I 1.852↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 302 ECL2 G => N 1.69↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 4.56x56 278 TM4 F => C 1.235↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.38x37 381 TM7 K => Q Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 2.60x60 187 TM2 K => R N/A N/A Runge S et al (2003)
glr_human 4.56x56 278 TM4 F => C 1.235↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 1.43x43 145 TM1 Y => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 2.67x67 194 TM2 I => K N/A N/A Runge S et al (2003)
glr_human 6.55x55 364 TM6 V => I 1.499↑ IC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 1.40x40 142 TM1 Q => Y 2.145↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 291 ECL2 N => D 2.015↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 303 ECL2 F => Y 1.265↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.37x36 380 TM7 A => I 1.499↑ IC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 217 ECL1 S => A 1.07↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 86 N-term P => S Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 5.40x40 308 TM5 R => A 4.405↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 40 N-term G => S N/A N/A Fujisawa T et al (1995)
glr_human 6.53x53 362 TM6 E => D Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.43x42 386 TM7 L => V 2.37↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 6.37x37 346 TM6 R => E Abolished effect pK(d) (Binding - Radioligand saturation) Mk-0893 Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 122 N-term Q => E 1.342↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 303 ECL2 F => Y 1.265↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 6.55x55 364 TM6 V => I 1.364↑ IC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 2.60x60 187 TM2 K => R 1.065↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 6.53x53 362 TM6 E => Q 10.69↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 5.38x381 306 TM5 I => A 4.115↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 108 N-term R => C 100.0↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 6.40x40 349 TM6 K => A 3.236↓ pK(d) (Binding - Radioligand saturation) Mk-0893 Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 5.37x38 305 TM5 W => L 1.785↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 6.52x52 361 TM6 H => A 2.185↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 1.47x47 149 TM1 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.38x37 381 TM7 K => A 3.665↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 36 N-term W => A Abolished effect Single-point (Functional - cAMP accumulation) glucagon Zhao LH et al (2016) 10.5281/zenodo.60790
glr_human 2.70x70 197 TM2 L => C 6.31↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 2.75x75 202 TM2 Y => C 316.228↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 5.40x40 308 TM5 R => Q 2.325↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 45.50x50 294 ECL2 C => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 125 N-term G => K 1.25↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.38x37 381 TM7 K => Q Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.67x67 194 TM2 I => K Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 303 ECL2 F => A 5.055↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 1.39x39 141 TM1 F => L 1.07↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 7.36x35 379 TM7 S => F 4.926↑ IC50 (Binding - Radioligand competition/displacement) glucagon-(Gln9Glu) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 6.57x57 366 TM6 A => M 1.212↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 5.36x37 304 TM5 W => A 14.035↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 87 N-term W => C 3981.072↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 1.43x43 145 TM1 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.43x43 238 TM3 N => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 42 N-term Q => C 79.433↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 213 ECL1 S => C 50.119↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 2.68x68 195 TM2 D => A 8.545↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 303 ECL2 F => A 5.055↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 5.43x43 311 TM5 V => I Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.42x41 385 TM7 D => E N/A N/A Runge S et al (2003)
glr_human 218 ECL1 D => Y 1.53↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.40x40 235 TM3 I => V 1.08↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 2.67x67 194 TM2 I => A 1.227↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.39x38 382 TM7 L => V 5.36↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 218 ECL1 D => Y 1.53↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 40 N-term G => S 3.786↓ K(d) (Binding - Radioligand saturation) glucagon Hansen LH et al (1996) 10.5281/zenodo.60790
glr_human 6.51x51 360 TM6 V => T N/A N/A Runge S et al (2003)
glr_human 369 ECL3 T => M 1.786↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.38x37 381 TM7 K => A 3.665↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.41x40 384 TM7 F => T 3.58↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.45x45 240 TM3 C => Y 1.15↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 40 N-term G => S 6.876↓ K(d) (Binding - Radioligand saturation) glucagon Hansen LH et al (1996) 10.5281/zenodo.60790
glr_human 40 N-term G => S N/A N/A Ristow M et al (1996)
glr_human 7.42x41 385 TM7 D => E 1.072↑ IC50 (Binding - Radioligand competition/displacement) glucagon-(Lys19Ser) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 214 ECL1 T => C 6.31↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 7.46x45 389 TM7 S => A 1.5↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.37x37 232 TM3 Q => H 1.315↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.29x29 224 TM3 C => S 79.433↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 1.52x52 154 TM1 G => S 1.03↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 1.48x48 150 TM1 S => A 1.379↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 40 N-term G => S N/A N/A Babadjanova G et al (1997)
glr_human 7.36x35 379 TM7 S => F 1.839↓ EC50 (Binding - Radioligand competition/displacement) glucagon-(Lys19Ser) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 209 ECL1 D => C 6.31↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 212 ECL1 V => W 2.353↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 40 N-term G => S 1000.0↑ pEC50 (Functional - cAMP accumulation) glucagon Hansen LH et al (1996) 10.5281/zenodo.60790
glr_human 298 ECL2 N => D 4.12↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.36x35 379 TM7 S => F 1.727↓ EC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 126 N-term E => R 1.942↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 98 N-term K => C Abolished effect pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 2.72x72 199 TM2 R => C 100.0↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 7.37x36 380 TM7 A => I 1.279↑ EC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 63 N-term D => K Abolished effect pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 298 ECL2 N => Q 10.55↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 204 ECL1 Q => T 1.183↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 94 N-term R => C 1584.893↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 113 N-term Q => A No effect EC50 (Functional - cAMP accumulation) glucagon Koth CM et al (2012) Hollenstein K et al (2014)
glr_human 7.42x41 385 TM7 D => E 6.944↑ EC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 1.29x29 131 TM1 Q => R 1.49↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 2.74x74 201 TM2 R => D Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 6.55x55 364 TM6 V => I N/A N/A Runge S et al (2003)
glr_human 7.31x30 374 TM7 Q => R 1.2↓ IC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 2.60x60 187 TM2 K => L Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 298 ECL2 N => A 9.55↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.68x68 195 TM2 D => N 5.555↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.39x38 382 TM7 L => V 5.36↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 369 ECL3 T => M N/A N/A Runge S et al (2003)
glr_human 3.38x38 233 TM3 Y => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.36x35 379 TM7 S => F N/A N/A Runge S et al (2003)
glr_human 7.31x30 374 TM7 Q => R 1.46↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 6.51x51 360 TM6 V => T 2.3↓ IC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 40 N-term G => S N/A N/A Rutherford S et al (1998)
glr_human 297 ECL2 S => A 1.14↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 127 N-term E => K 1.195↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 2.71x71 198 TM2 L => V 2.82↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 210 ECL1 L => C 1.585↑ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 2.74x74 201 TM2 R => C 79.433↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 31 N-term F => W 1.515↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 7.36x35 379 TM7 S => F 1.167↓ IC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 212 ECL1 V => C 10.0↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 291 ECL2 N => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 40 N-term G => S N/A N/A Elbein SC et al (1996)
glr_human 1.40x40 142 TM1 Q => Y 2.145↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 2.68x68 195 TM2 D => A 8.545↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.35x34 378 TM7 R => Q Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Yang D et al (2016) Yang D et al (2016)
glr_human 4.60x60 282 TM4 W => H Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 5.38x381 306 TM5 I => A 4.115↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 216 ECL1 L => C 79.433↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 122 N-term Q => A 1.38↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.28x28 223 TM3 G => C 3.981↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 1.33x33 135 TM1 A => P Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 298 ECL2 N => A 9.55↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 6.57x57 366 TM6 A => M 1.212↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.38x37 381 TM7 K => L Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 40 N-term G => S N/A N/A Ogata M et al (1996)
glr_human 208 ECL1 D => R 5.04↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.36x35 379 TM7 S => F 1.45↓ IC50 (Binding - Radioligand competition/displacement) glucagon Yang D et al (2016) Yang D et al (2016)
glr_human 2.73x73 200 TM2 T => W 1.942↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 1.47x47 149 TM1 Y => H 6.4↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 6.53x53 362 TM6 E => A 6.65↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 40 N-term G => S N/A N/A Odawara M et al (1996)
glr_human 3.29x29 224 TM3 C => S 63.096↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 1.31x31 133 TM1 E => P 2.955↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 64 N-term K => E Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 86 N-term P => S Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.35x34 378 TM7 R => A 6.475↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.41x41 236 TM3 V => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 40 N-term G => S N/A N/A Hager J et al (1995)
glr_human 291 ECL2 N => D 2.015↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 6.40x40 349 TM6 K => M 10.0↓ pK(b) (Functional - cAMP accumulation) Mk-0893 Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 127 N-term E => K 1.195↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.60x60 187 TM2 K => Q Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.36x35 379 TM7 S => F 1.072↑ IC50 (Binding - Radioligand competition/displacement) glucagon-(Lys19Ser) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 7.36x35 379 TM7 S => F 1.0 IC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 40 N-term G => S N/A N/A Huang CN et al (1999)
glr_human 5.39x39 307 TM5 L => I 1.475↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.42x41 385 TM7 D => E 4.5↓ IC50 (Binding - Radioligand competition/displacement) glucagon Yang D et al (2016) Yang D et al (2016)
glr_human 5.39x39 307 TM5 L => I 1.475↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 1.44x44 146 TM1 T => S N/A IC50 (Binding - Radioligand competition/displacement) glucagon Yang D et al (2016) Yang D et al (2016)
glr_human 40 N-term G => S 5.388↓ K(d) (Binding - Radioligand saturation) glucagon Hansen LH et al (1996) 10.5281/zenodo.60790
glr_human 7.41x40 384 TM7 F => T 8.182↓ EC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 7.42x41 385 TM7 D => E 35.714↑ IC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 6.55x55 364 TM6 V => I 1.909↓ EC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 128 N-term I => Q 1.481↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.74x74 201 TM2 R => D Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 56 N-term L => C 31.623↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 2.76x76 203 TM2 S => C 5.012↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 7.39x38 382 TM7 L => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.44x44 239 TM3 Y => A N/A N/A Cascieri MA et al (1999)
glr_human 4.68x68 290 TM4 E => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 5.37x38 305 TM5 W => L 1.785↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 5.36x37 304 TM5 W => L 4.65↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.46x45 389 TM7 S => A 1.5↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 45.51x51 295 ECL2 W => H Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 297 ECL2 S => R 1.57↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.33x33 228 TM3 A => V 2.84↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.71x71 198 TM2 L => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.44x43 387 TM7 F => S 2.34↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 7.38x37 381 TM7 K => L Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.74x74 201 TM2 R => A 6.59↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 1.43x43 145 TM1 Y => F 2.15↓ IC50 (Binding - Radioligand competition/displacement) glucagon Yang D et al (2016) Yang D et al (2016)
glr_human 45.51x51 295 ECL2 W => F 1.45↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.36x36 231 TM3 M => T Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 2.62x62 189 TM2 S => L 1.361↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 98 N-term K => C 6309.573↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 299 ECL2 D => S 1.435↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 63 N-term D => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 6.53x53 362 TM6 E => Q 10.69↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.45x45 240 TM3 C => Y 1.15↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 291 ECL2 N => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 369 ECL3 T => M 1.499↑ IC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 7.31x30 374 TM7 Q => R 1.091↓ EC50 (Binding - Radioligand competition/displacement) glucagon Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 6.37x37 346 TM6 R => E 1.096↓ pK(i) (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 3.36x36 231 TM3 M => A 1.036↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.43x42 386 TM7 L => V 2.37↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 3.37x37 232 TM3 Q => L Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 36 N-term W => A Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.60x60 187 TM2 K => L Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 215 ECL1 W => L Abolished IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 2.65x65 192 TM2 L => F Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 3.44x44 239 TM3 Y => A 3.462↓ IC50 (Binding - Radioligand competition/displacement) L168,049 Cascieri MA et al (1999) Hollenstein K et al (2014)
glr_human 113 N-term Q => C 199.526↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 6.40x40 349 TM6 K => M 1.096↓ pK(i) (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 4.68x68 290 TM4 E => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 5.40x40 308 TM5 R => Q 2.325↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 30 N-term D => L 1.176↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 6.41x41 350 TM6 S => A 1.096↓ pK(i) (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 63 N-term D => C 3981.072↓ pEC50 (Functional - cAMP accumulation) glucagon Prevost M et al (2010) Hollenstein K et al (2014)
glr_human 1.38x38 140 TM1 S => F 1.43↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 209 ECL1 D => Q 1.19↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 7.43x42 386 TM7 L => A 9.125↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 369 ECL3 T => M 2.32↑ EC50 (Binding - Radioligand competition/displacement) glucagon-(Ser8Ala) Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
glr_human 8.47x47 404 H8 N => A 5.012↓ pK(b) (Functional - cAMP accumulation) Mk-0893 Siu FY et al (2013) Nijmeijer S et al (2016)
glr_human 208 ECL1 D => Q Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)
glr_human 2.60x60 187 TM2 K => R 1.065↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 129 N-term E => R 1.639↑ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Hollenstein K et al (2014)
glr_human 215 ECL1 W => C 79.433↓ pEC50 (Functional - cAMP accumulation) glucagon Roberts DJ et al (2011) Hollenstein K et al (2014)
glr_human 1.43x43 145 TM1 Y => N 10.77↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013)
glr_human 1.43x43 145 TM1 Y => N 10.77↓ IC50 (Binding - Radioligand competition/displacement) glucagon Siu FY et al (2013) Yang D et al (2016)


Residue

Diagrams

ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 V T D E H A ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q