Mutant Browser
Download| Protein name | Generic number | Position | Segment | Mutation | FoldChange or Qual | Exp Type | Ligand | Reference | Review |
|---|---|---|---|---|---|---|---|---|---|
| Protein name | Generic number | Segment | Position | Mutation | FoldChange or Qual | Exp Type | Ligand | Reference | Review |
| acm1_human | 181 | ECL2 | Q => A | 7.246↑ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 3.33x33 | 106 | TM3 | Y => F | 2.3↓ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.54x54 | 127 | TM3 | V => A | N/A | N/A | Moro O et al (1994) | ||
| acm1_human | 5.35x36 | 185 | TM5 | Q => A | 1.318↑ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 6.51x51 | 381 | TM6 | Y => A | 117.49↓ | pK(A) (Binding - Radioligand competition/displacement) | Acetylcholine | Avlani VA et al (2010) | Vass M et al (2018) |
| acm1_human | 183 | ECL2 | L => A | 3.631↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => F | 2.512↓ | pK(b) (Binding - Radioligand competition/displacement) | Benzoquinazolinone 12 | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => F | 7.586↓ | pK(b) (Binding - Radioligand competition/displacement) | Benzoquinazolinone 12 | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.441↑ | K(d) (Binding - Radioligand saturation) | [3H](R)-QNB | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 182 | ECL2 | F => A | 3.388↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 1.175↑ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 392 | ECL3 | K => A | 1.905↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 45.52x52 | 180 | ECL2 | I => A | 1.622↓ | pK(i) (Binding - Radioligand competition/displacement) | Atropine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.32x31 | 397 | TM7 | E => A | 1.175↑ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 28.9↓ | K(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => F | 4.571↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 2.089↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 183 | ECL2 | L => A | 1.82↓ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 2.61x60 | 82 | TM2 | Y => F | 2.561↓ | IC50 (Binding - Radioligand competition/displacement) | Pirenzepine | Drubbisch V et al (1992) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 11.111↑ | K(i) (Binding - Radioligand competition/displacement) | Arecoline | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 3.33x33 | 106 | TM3 | Y => A | 4.571↓ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 4.365↓ | pK(d) (Binding - Radioligand saturation) | [3H](R)-QNB | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.52x52 | 417 | TM7 | C => S | N/A | N/A | Lucas JL et al (2001) | ||
| acm1_human | 2.61x60 | 82 | TM2 | Y => F | 1.35↑ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 1.429↑ | K(i) (Binding - Radioligand competition/displacement) | Arecoline | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 2.089↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 394 | ECL3 | C => A | 2.137↑ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 23.50x50 | 91 | ECL1 | W => F | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 182 | ECL2 | F => A | 1.738↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 1.235↓ | K(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 3.32x32 | 105 | TM3 | D => E | 29.512↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 21.878↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.24x24 | 354 | TM6 | T => A | N/A | N/A | Lameh J et al (1992) | ||
| acm1_human | 3.28x28 | 101 | TM3 | W => F | 1.38↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.36x35 | 401 | TM7 | E => A | 3.631↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 4.66x66 | 166 | TM4 | Y => A | 2.455↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 181 | ECL2 | Q => A | 1.122↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 3.52x52 | 125 | TM3 | F => A | N/A | N/A | Moro O et al (1994) | ||
| acm1_human | 3.33x33 | 106 | TM3 | Y => A | 1.479↑ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 182 | ECL2 | F => A | 1.047↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 18.197↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 45.52x52 | 180 | ECL2 | I => A | 5.128↑ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 2.754↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 42.308↓ | K(i) (Binding - Radioligand competition/displacement) | Huang XP et al (1999) | Vass M et al (2018) | |
| acm1_human | 5.64x64 | 214 | TM5 | E => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 9.12↓ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 9.12↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 2.138↓ | pK(i) (Binding - Radioligand competition/displacement) | Atropine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => W | 1.739↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 1.175↑ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 2.722↓ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 4.677↓ | pK(i) (Binding - Radioligand competition/displacement) | Atropine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 2.56x551 | 77 | TM2 | F => I | 2.138↓ | pK(A) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Avlani VA et al (2010) | Vass M et al (2018) |
| acm1_human | 6.51x51 | 381 | TM6 | Y => A | 128.825↓ | pK(i) (Binding - Radioligand competition/displacement) | Atropine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => A | 9.772↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 34.51x51 | 131 | ICL2 | L => M | N/A | N/A | Moro O et al (1993) | ||
| acm1_human | 5.35x36 | 185 | TM5 | Q => A | 1.096↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 322 | ICL3 | S => A | N/A | N/A | Lameh J et al (1992) | |||
| acm1_human | 6.32x32 | 362 | TM6 | K => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 6.38x38 | 368 | TM6 | S => A | 1.055↑ | Single-point (Binding - Other) | [3H]N-methyl scopolamine | Lameh J et al (1992) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => F | 2.344↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 184 | ECL2 | S => A | 1.047↑ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 6.59x59 | 389 | TM6 | T => P | N/A | N/A | Huang XP et al (1999) | ||
| acm1_human | 4.66x66 | 166 | TM4 | Y => A | 1.38↓ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 2.884↓ | pK(i) (Binding - Radioligand competition/displacement) | Xanomeline | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 228 | ICL3 | S => A | 1.058↓ | Single-point (Binding - Other) | [3H]N-methyl scopolamine | Lameh J et al (1992) | Vass M et al (2018) | |
| acm1_human | 3.29x29 | 102 | TM3 | L => A | 2.344↓ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.32x32 | 105 | TM3 | D => E | 1.122↑ | pK(i) (Binding - Radioligand competition/displacement) | Atropine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 3.32x32 | 105 | TM3 | D => E | 1.585↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 15.136↓ | pK(b) (Binding - Radioligand competition/displacement) | Benzoquinazolinone 12 | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 1.0 | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 7.943↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 395 | ECL3 | V => A | 3.548↓ | pK(A) (Binding - Radioligand saturation) | [3H]QNB | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 392 | ECL3 | K => A | 1.23↓ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 7.36x35 | 401 | TM7 | E => A | 1.698↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 7.36x35 | 401 | TM7 | E => A | 1.862↓ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 1.778↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.37x37 | 110 | TM3 | N => A | 3.2↓ | K(i) (Binding - Radioligand competition/displacement) | Pilocarpine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 7.47x47 | 412 | TM7 | T => A | 1.3↓ | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 5.623↓ | pK(i) (Binding - Radioligand competition/displacement) | Atropine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 23.529↓ | K(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 170 | ECL2 | E => K | 1.148↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 7.31x30 | 396 | TM7 | P => A | 1.585↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 392 | ECL3 | K => A | 1.202↓ | pK(i) (Binding - Radioligand competition/displacement) | Xanomeline | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 7.49x49 | 414 | TM7 | N => H | N/A | N/A | Ballesteros JA et al (2001) | ||
| acm1_human | 183 | ECL2 | L => A | 5.37↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 6.26x26 | 356 | TM6 | S => A | N/A | N/A | Lameh J et al (1992) | ||
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 111.111↑ | K(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 4.69x69 | 169 | TM4 | G => A | 6.31↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.48x48 | 378 | TM6 | W => F | 1.111↑ | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 45.52x52 | 180 | ECL2 | I => A | 1.549↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 2.0↓ | K(h) (Binding - Radioligand competition/displacement) | CDD-0098 | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.36x35 | 401 | TM7 | E => A | 1.175↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 17.783↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => F | 1.202↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.47x47 | 412 | TM7 | T => A | 1.0 | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 171 | ECL2 | R => A | 1.23↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | N/A | N/A | Huang XP et al (1999) | ||
| acm1_human | 45.51x51 | 179 | ECL2 | Y => W | 1.072↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 182 | ECL2 | F => A | 1.318↑ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 4.571↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.46x46 | 411 | TM7 | S => A | 2.1↓ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 2.50x50 | 71 | TM2 | D => N | N/A | N/A | Lameh J et al (1992) | ||
| acm1_human | 7.33x32 | 398 | TM7 | T => A | 1.047↑ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | N/A | N/A | Huang XP et al (1998) | ||
| acm1_human | 6.44x44 | 374 | TM6 | F => H | N/A | N/A | Ballesteros JA et al (2001) | ||
| acm1_human | 3.29x29 | 102 | TM3 | L => A | 17.783↓ | pK(i) (Binding - Radioligand competition/displacement) | Atropine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => A | 37.154↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 8.511↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => F | 1.148↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 394 | ECL3 | C => A | 1.318↑ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 10.965↓ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 2.62x61 | 83 | TM2 | T => A | 1.148↑ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 2.5↓ | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 1.096↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 2.50x50 | 71 | TM2 | D => N | N/A | N/A | Lameh J et al (1992) | ||
| acm1_human | 7.33x32 | 398 | TM7 | T => A | 1.175↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 181 | ECL2 | Q => A | 1.549↓ | pK(i) (Binding - Radioligand competition/displacement) | Atropine | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 3.21x21 | 94 | TM3 | G => A | 2.291↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.3↓ | K(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 1.621↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.54x54 | 127 | TM3 | V => A | N/A | N/A | Moro O et al (1993) | ||
| acm1_human | 6.60x60 | 390 | TM6 | F => A | 1.413↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.32x32 | 105 | TM3 | D => N | 31.623↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Suga H et al (2013) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => F | 2.239↓ | pK(i) (Binding - Radioligand competition/displacement) | Himbacine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.32x32 | 105 | TM3 | D => E | 3.162↓ | pK(i) (Binding - Radioligand competition/displacement) | Xanomeline | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 1.025↑ | K(i) (Binding - Radioligand competition/displacement) | Arecoline | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 3.29x29 | 102 | TM3 | L => A | 22.387↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.318↓ | K(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 181 | ECL2 | Q => A | 1.739↑ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 227.273↓ | K(i) (Binding - Radioligand competition/displacement) | l-Hyoscyamine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 3.37x37 | 110 | TM3 | N => Q | 3.548↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Thal DM et al (2016) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 3.75↓ | K(h) (Binding - Radioligand competition/displacement) | Carbachol | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 395 | ECL3 | V => A | 436.516↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 2.7↓ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 1.23↓ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => F | 25.704↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.39x40 | 189 | TM5 | T => A | 1.548↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.51x51 | 381 | TM6 | Y => A | 1.072↓ | pK(A) (Binding - Radioligand saturation) | [3H]QNB | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => F | 3.236↓ | pK(i) (Binding - Radioligand competition/displacement) | Methoctramine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 29.412↑ | K(l) (Binding - Radioligand competition/displacement) | Carbachol | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | N/A | N/A | Huang XP et al (1999) | ||
| acm1_human | 5.62x62 | 212 | TM5 | Y => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 4.365↓ | pK(i) (Binding - Radioligand competition/displacement) | l-Hyoscyamine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => A | 1.66↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 8.53x53 | 428 | H8 | T => A | N/A | N/A | Lameh J et al (1992) | ||
| acm1_human | 182 | ECL2 | F => A | 1.738↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 173 | ECL2 | V => M | N/A | N/A | Lucas JL et al (2001) | |||
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 23.988↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 4.69x69 | 169 | TM4 | G => A | 4.365↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 392 | ECL3 | K => A | 2.818↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 1.202↑ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 1.148↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.21x21 | 94 | TM3 | G => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 45.52x52 | 180 | ECL2 | I => A | 3.311↑ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 1.479↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 86.275↓ | K(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 4.65x65 | 165 | TM4 | Q => A | 1.318↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 105.0↓ | K(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 34.51x51 | 131 | ICL2 | L => N | N/A | N/A | Moro O et al (1994) | ||
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 3.548↓ | pK(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.46x46 | 411 | TM7 | S => A | 1.1↓ | K(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 4.64x64 | 164 | TM4 | W => A | 1.479↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => F | 1.862↑ | IC50 (Binding - Radioligand competition/displacement) | Carbachol | Drubbisch V et al (1992) | Vass M et al (2018) |
| acm1_human | 3.33x33 | 106 | TM3 | Y => A | 50.119↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.40x39 | 405 | TM7 | W => A | 1.23↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.30x30 | 360 | TM6 | E => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 45.52x52 | 180 | ECL2 | I => A | 8.71↓ | pK(i) (Binding - Radioligand competition/displacement) | Xanomeline | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 1.66↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 6.316↓ | K(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.31x30 | 396 | TM7 | P => A | 1.202↑ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 183 | ECL2 | L => A | 1.862↑ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 6.48x48 | 378 | TM6 | W => F | 4.8↓ | K(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => F | 16.596↓ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 3.29x29 | 102 | TM3 | L => A | 1.905↓ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 183 | ECL2 | L => A | 1.413↓ | pK(i) (Binding - Radioligand competition/displacement) | Xanomeline | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 45.52x52 | 180 | ECL2 | I => A | 3.472↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => F | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 2.399↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 3.106↑ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 2.56x551 | 77 | TM2 | F => I | 2.755↑ | pK(A) (Binding - Radioligand saturation) | [3H]QNB | Avlani VA et al (2010) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => F | N/A | N/A | Drubbisch V et al (1992) | ||
| acm1_human | 2.56x551 | 77 | TM2 | F => I | 1.514↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 2.344↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 184 | ECL2 | S => A | 1.621↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 6.51x51 | 381 | TM6 | Y => A | 162.181↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 2.62x61 | 83 | TM2 | T => A | 1.23↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 330 | ICL3 | T => A | 1.018↑ | Single-point (Binding - Other) | [3H]N-methyl scopolamine | Lameh J et al (1992) | Vass M et al (2018) | |
| acm1_human | 2.56x551 | 77 | TM2 | F => I | 1.175↓ | pK(A) (Binding - Radioligand competition/displacement) | Pilocarpine | Avlani VA et al (2010) | Vass M et al (2018) |
| acm1_human | 2.62x61 | 83 | TM2 | T => A | 1.259↓ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 8.913↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.36x35 | 401 | TM7 | E => A | 2.884↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 34.51x51 | 131 | ICL2 | L => D | N/A | N/A | Moro O et al (1994) | ||
| acm1_human | 6.60x60 | 390 | TM6 | F => A | 1.148↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 393 | ECL3 | D => A | 1.738↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 2.692↓ | K(i) (Binding - Radioligand competition/displacement) | AF-DX 116 | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 4.64x64 | 164 | TM4 | W => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 7.39x38 | 404 | TM7 | Y => F | 1.072↑ | pK(i) (Binding - Radioligand competition/displacement) | Methoctramine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 172 | ECL2 | T => A | 1.122↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 6.48x48 | 378 | TM6 | W => A | 4.8↓ | K(i) (Binding - Radioligand competition/displacement) | Pilocarpine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 5.888↓ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 3.09↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => F | 1.479↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => F | 5.37↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => F | 7.244↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.51x51 | 381 | TM6 | Y => A | 2.089↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.26x26 | 356 | TM6 | S => A | 1.091↑ | Single-point (Binding - Other) | [3H]N-methyl scopolamine | Lameh J et al (1992) | Vass M et al (2018) |
| acm1_human | 6.61x61 | 391 | TM6 | C => A | 1.905↑ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | N/A | N/A | Gregory KJ et al (2010) | ||
| acm1_human | 3.28x28 | 101 | TM3 | W => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 6.48x48 | 378 | TM6 | W => A | 115.0↓ | K(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 1.259↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 34.51x51 | 131 | ICL2 | L => F | N/A | N/A | Moro O et al (1994) | ||
| acm1_human | 7.39x38 | 404 | TM7 | Y => A | 1.349↓ | pK(i) (Binding - Radioligand competition/displacement) | Methoctramine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.60x60 | 390 | TM6 | F => A | 1.479↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.36x36 | 366 | TM6 | T => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 2.56x551 | 77 | TM2 | F => I | 4.074↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 55.556↑ | K(l) (Binding - Radioligand competition/displacement) | Acetylcholine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => Y | 3.548↓ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 2.884↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 1.905↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 1.445↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 4.337↓ | K(l) (Binding - Radioligand competition/displacement) | Carbachol | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => F | 2.399↓ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => A | 7.943↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => F | 1.349↓ | pK(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 4.677↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 7.40x39 | 405 | TM7 | W => A | 6.897↑ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => A | 14.791↓ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 15.556↓ | K(d) (Binding - Radioligand saturation) | [3H](R)-QNB | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => F | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 7.39x38 | 404 | TM7 | Y => A | 22.909↓ | pK(i) (Binding - Radioligand competition/displacement) | Himbacine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.36x35 | 401 | TM7 | E => A | 1.585↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.835↑ | K(l) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => F | 5.623↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 182 | ECL2 | F => A | 1.148↑ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 6.30x30 | 360 | TM6 | E => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 182 | ECL2 | F => A | 1.0 | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 45.52x52 | 180 | ECL2 | I => A | 4.367↑ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 2.884↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 23.49x49 | 90 | ECL1 | H => A | 1.0 | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 2.62x61 | 83 | TM2 | T => A | 1.175↑ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 322 | ICL3 | S => A | 1.058↓ | Single-point (Binding - Other) | [3H]N-methyl scopolamine | Lameh J et al (1992) | Vass M et al (2018) | |
| acm1_human | 2.61x60 | 82 | TM2 | Y => F | 1.464↑ | IC50 (Binding - Radioligand competition/displacement) | Carbachol | Drubbisch V et al (1992) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 4.266↓ | pK(i) (Binding - Radioligand competition/displacement) | Methoctramine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 5.455↓ | K(i) (Binding - Radioligand competition/displacement) | (-)-N-methyl scopolamine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 170 | ECL2 | E => A | 1.047↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 23.49x49 | 90 | ECL1 | H => A | 1.548↑ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 182 | ECL2 | F => A | 1.202↓ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | N/A | N/A | Huang XP et al (1999) | ||
| acm1_human | 3.54x54 | 127 | TM3 | V => A | N/A | N/A | Shockley MS et al (1997) | ||
| acm1_human | 392 | ECL3 | K => A | 1.585↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.062↓ | K(h) (Binding - Radioligand competition/displacement) | Carbachol | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 2.399↓ | pK(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 2.128↓ | K(l) (Binding - Radioligand competition/displacement) | Acetylcholine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 34.53x53 | 133 | ICL2 | Y => A | N/A | N/A | Moro O et al (1993) | ||
| acm1_human | 254 | ICL3 | T => A | 2.63↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Sawyer GW et al (2008) | Vass M et al (2018) | |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.852↓ | K(l) (Binding - Radioligand competition/displacement) | CDD-0098 | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 6.48x48 | 378 | TM6 | W => A | 10.0↑ | K(i) (Binding - Radioligand competition/displacement) | McN-A343 | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 14.085↑ | K(h) (Binding - Radioligand competition/displacement) | Acetylcholine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 6.30x30 | 360 | TM6 | E => A | 10.989↑ | IC50 (Binding - Radioligand competition/displacement) | Carbachol | Hogger P et al (1995) | Vass M et al (2018) |
| acm1_human | 3.37x37 | 110 | TM3 | N => Q | 1.35↑ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Thal DM et al (2016) | Vass M et al (2018) |
| acm1_human | 7.31x30 | 396 | TM7 | P => A | 1.318↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.32x32 | 105 | TM3 | D => E | 19.953↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 9.772↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => F | 8.128↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => W | 1.381↑ | pK(b) (Binding - Radioligand competition/displacement) | Benzoquinazolinone 12 | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 269 | ICL3 | L => H | N/A | N/A | Ballesteros JA et al (2001) | |||
| acm1_human | 392 | ECL3 | K => A | 1.905↓ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 393 | ECL3 | D => A | 1.82↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 3.33x33 | 106 | TM3 | Y => A | 870.964↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 182 | ECL2 | F => A | 1.38↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 170 | ECL2 | E => K | 14.454↓ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 2.884↓ | pK(i) (Binding - Radioligand competition/displacement) | Xanomeline | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 23.49x49 | 90 | ECL1 | H => A | 3.09↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 394 | ECL3 | C => A | N/A | N/A | Matsui H et al (1995) | |||
| acm1_human | 392 | ECL3 | K => A | 1.047↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 7.35x34 | 400 | TM7 | W => Y | 2.457↑ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 1.25↑ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => F | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 3.28x28 | 101 | TM3 | W => F | 2.188↑ | pK(i) (Binding - Radioligand competition/displacement) | Himbacine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.61x61 | 391 | TM6 | C => A | 1.096↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 181 | ECL2 | Q => A | 2.041↑ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 393 | ECL3 | D => A | 1.288↓ | pK(i) (Binding - Radioligand competition/displacement) | Atropine | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 182 | ECL2 | F => A | 3.311↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 182 | ECL2 | F => A | 1.318↑ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 50.0↑ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 182 | ECL2 | F => A | 2.818↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 55.556↑ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.781↓ | K(i) (Binding - Radioligand competition/displacement) | APE | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 392 | ECL3 | K => A | 1.259↑ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 4.65x65 | 165 | TM4 | Q => A | 1.413↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.21x21 | 94 | TM3 | G => A | 1.413↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.51x51 | 381 | TM6 | Y => A | 1.658↑ | pK(i) (Binding - Radioligand competition/displacement) | Xanomeline | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 3.32x32 | 105 | TM3 | D => N | 35.481↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Suga H et al (2010) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 1.23↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.32x32 | 105 | TM3 | D => N | 56.234↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Suga H et al (2013) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 13.183↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 393 | ECL3 | D => A | 1.096↓ | pK(i) (Binding - Radioligand competition/displacement) | Xanomeline | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 2.56x551 | 77 | TM2 | F => I | 1.259↓ | pK(A) (Binding - Radioligand competition/displacement) | AC-42 | Avlani VA et al (2010) | Vass M et al (2018) |
| acm1_human | 3.33x33 | 106 | TM3 | Y => A | 34.674↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => A | 1.698↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 21.878↓ | pK(i) (Binding - Radioligand competition/displacement) | Xanomeline | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 5.62x62 | 212 | TM5 | Y => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 85.882↓ | K(i) (Binding - Radioligand competition/displacement) | Scopolamine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => A | 3.02↓ | pK(i) (Binding - Radioligand competition/displacement) | Methoctramine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => F | 1.318↑ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.29x29 | 102 | TM3 | L => A | 24.547↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 2.291↓ | pK(i) (Binding - Radioligand competition/displacement) | Trihexyphenidyl | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 184 | ECL2 | S => A | N/A | N/A | Matsui H et al (1995) | |||
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 9.688↓ | K(d) (Binding - Radioligand saturation) | [3H](R)-QNB | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 4.64x64 | 164 | TM4 | W => A | 1.122↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 392 | ECL3 | K => A | 1.905↓ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 392 | ECL3 | K => A | 1.413↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 2.138↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 182 | ECL2 | F => A | 3.162↓ | pK(i) (Binding - Radioligand competition/displacement) | Atropine | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 13.804↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 27.778↑ | K(l) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 11.749↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.51x51 | 381 | TM6 | Y => A | 2.457↑ | pK(A) (Binding - Radioligand competition/displacement) | AC-42 | Avlani VA et al (2010) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => F | 2.088↑ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 2.951↓ | pK(i) (Binding - Radioligand competition/displacement) | l-Hyoscyamine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.667↑ | K(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 1.072↑ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 272 | ICL3 | Y => H | N/A | N/A | Ballesteros JA et al (2001) | |||
| acm1_human | 3.28x28 | 101 | TM3 | W => A | N/A | N/A | Leach K et al (2011) | ||
| acm1_human | 7.32x31 | 397 | TM7 | E => A | 1.023↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 181 | ECL2 | Q => A | 1.096↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 5.61x61 | 211 | TM5 | I => A | 1.758↓ | IC50 (Binding - Radioligand competition/displacement) | Carbachol | Hogger P et al (1995) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => A | 7.943↓ | pK(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.286↓ | K(i) (Binding - Radioligand competition/displacement) | Arecoline | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 2.188↓ | pK(d) (Binding - Radioligand saturation) | [3H](R)-QNB | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 34.53x53 | 133 | ICL2 | Y => A | N/A | N/A | Moro O et al (1994) | ||
| acm1_human | 6.48x48 | 378 | TM6 | W => A | 1.6↓ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 7.31x30 | 396 | TM7 | P => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 1.846↓ | K(l) (Binding - Radioligand competition/displacement) | Acetylcholine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 394 | ECL3 | C => A | 1.445↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 7.36x35 | 401 | TM7 | E => A | 1.148↑ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.32x31 | 397 | TM7 | E => A | 1.66↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 1.667↑ | K(i) (Binding - Radioligand competition/displacement) | CDD-0102 | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 6.61x61 | 391 | TM6 | C => A | 2.041↑ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.46x46 | 411 | TM7 | S => A | 1.6↓ | K(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 6.32x32 | 362 | TM6 | K => A | 4.848↓ | IC50 (Binding - Radioligand competition/displacement) | Carbachol | Hogger P et al (1995) | Vass M et al (2018) |
| acm1_human | 5.61x61 | 211 | TM5 | I => A | N/A | N/A | Shockley MS et al (1997) | ||
| acm1_human | 3.37x37 | 110 | TM3 | N => A | 6.4↓ | K(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.32x32 | 105 | TM3 | D => E | 1.35↑ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => F | 1.096↑ | pK(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 1.667↑ | K(i) (Binding - Radioligand competition/displacement) | Pilocarpine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.37x37 | 110 | TM3 | N => A | 13.3↓ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => F | 1.869↑ | IC50 (Binding - Radioligand competition/displacement) | Carbachol | Drubbisch V et al (1992) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 1.148↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 7.47x47 | 412 | TM7 | T => A | 1.111↑ | K(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 181 | ECL2 | Q => A | N/A | N/A | Matsui H et al (1995) | |||
| acm1_human | 2.64x63 | 85 | TM2 | Y => F | 1.349↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 2.62x61 | 83 | TM2 | T => A | 1.318↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.29x29 | 102 | TM3 | L => A | 3.548↓ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.36x35 | 401 | TM7 | E => A | 1.259↓ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.51x51 | 381 | TM6 | Y => A | 1.996↑ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 3.29x29 | 102 | TM3 | L => A | 2.884↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 174 | ECL2 | L => P | 12.589↓ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 7.413↓ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => F | 6.457↓ | pK(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 4.57x57 | 157 | TM4 | W => F | 7.4↓ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => A | 3.631↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.32x32 | 105 | TM3 | D => E | 2.138↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 18.621↓ | pK(b) (Binding - Radioligand competition/displacement) | Benzoquinazolinone 12 | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.44x44 | 374 | TM6 | F => A | 5.623↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.32x32 | 362 | TM6 | K => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 8.182↓ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 174 | ECL2 | L => P | 1.175↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 4.786↓ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 5.61x61 | 211 | TM5 | I => A | N/A | N/A | Shockley MS et al (1997) | ||
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 2272.727↓ | K(i) (Binding - Radioligand competition/displacement) | (-)-N-methyl scopolamine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => P | N/A | N/A | Huang XP et al (1998) | ||
| acm1_human | 3.21x21 | 94 | TM3 | G => A | 2.63↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.61x61 | 391 | TM6 | C => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 4.69x69 | 169 | TM4 | G => A | 2.399↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 9.0↓ | K(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => F | 1.047↑ | IC50 (Binding - Radioligand competition/displacement) | Atropine | Drubbisch V et al (1992) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => A | 1.318↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 2.0↑ | K(i) (Binding - Radioligand competition/displacement) | Arecoline | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 2.899↑ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 6.48x48 | 378 | TM6 | W => A | 288.2↓ | K(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 5.66x66 | 216 | TM5 | E => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 90.909↑ | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 3.33x33 | 106 | TM3 | Y => F | 3.6↓ | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 2.951↓ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.40x39 | 405 | TM7 | W => A | 16.129↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => A | 1.318↑ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 395 | ECL3 | V => A | 1.35↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 4.57x57 | 157 | TM4 | W => A | 3.388↓ | pK(A) (Binding - Radioligand saturation) | [3H]QNB | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 172 | ECL2 | T => A | 1.585↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 177 | ECL2 | Q => E | 1.289↑ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | N/A | N/A | Huang XP et al (1999) | ||
| acm1_human | 5.39x40 | 189 | TM5 | T => A | 7.413↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 182 | ECL2 | F => A | N/A | N/A | Matsui H et al (1995) | |||
| acm1_human | 3.32x32 | 105 | TM3 | D => E | 3.086↑ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => Y | N/A | N/A | Huang XP et al (1998) | ||
| acm1_human | 3.28x28 | 101 | TM3 | W => F | 2.2↓ | K(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 77.625↓ | pK(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.0 | K(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 183 | ECL2 | L => A | 11.22↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 1.939↓ | K(l) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 171 | ECL2 | R => A | 2.884↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 3.37x37 | 110 | TM3 | N => A | 8.3↓ | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 7.31x30 | 396 | TM7 | P => A | 1.148↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 284 | ICL3 | S => A | N/A | N/A | Moro O et al (1993) | |||
| acm1_human | 34.51x51 | 131 | ICL2 | L => N | N/A | N/A | Moro O et al (1993) | ||
| acm1_human | 2.61x60 | 82 | TM2 | Y => F | 1.575↑ | K(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Drubbisch V et al (1992) | Vass M et al (2018) |
| acm1_human | 393 | ECL3 | D => A | 1.738↓ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 4.57x57 | 157 | TM4 | W => F | 6.0↓ | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 263 | ICL3 | C => A | 2.089↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Sawyer GW et al (2008) | Vass M et al (2018) | |
| acm1_human | 4.57x57 | 157 | TM4 | W => F | 96.7↓ | K(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => F | 22.909↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.39x40 | 189 | TM5 | T => A | 3.02↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 34.51x51 | 131 | ICL2 | L => A | N/A | N/A | Shockley MS et al (1997) | ||
| acm1_human | 6.24x24 | 354 | TM6 | T => A | 1.127↑ | Single-point (Binding - Other) | [3H]N-methyl scopolamine | Lameh J et al (1992) | Vass M et al (2018) |
| acm1_human | 184 | ECL2 | S => A | 1.622↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 7.31x30 | 396 | TM7 | P => A | 1.35↑ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.33x32 | 398 | TM7 | T => A | 1.413↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 45.52x52 | 180 | ECL2 | I => A | 1.023↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 393 | ECL3 | D => A | 2.344↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 23.49x49 | 90 | ECL1 | H => A | 1.047↑ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => F | 1.071↓ | IC50 (Binding - Radioligand competition/displacement) | Atropine | Drubbisch V et al (1992) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => F | 1.318↑ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => F | 1.445↓ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.30x30 | 360 | TM6 | E => A | N/A | N/A | Shockley MS et al (1997) | ||
| acm1_human | 3.21x21 | 94 | TM3 | G => A | 1.381↑ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 1.034↓ | K(i) (Binding - Radioligand competition/displacement) | CDD-0098 | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 2.56x551 | 77 | TM2 | F => I | 1.047↑ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => F | 2.088↑ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 2.62x61 | 83 | TM2 | T => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 4.786↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 4.266↓ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 183 | ECL2 | L => A | 2.951↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 34.56x56 | 136 | ICL2 | K => A | N/A | N/A | Moro O et al (1994) | ||
| acm1_human | 45.51x51 | 179 | ECL2 | Y => F | 1.072↑ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 2.56x551 | 77 | TM2 | F => I | 1.175↑ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.36x36 | 366 | TM6 | T => A | 2.747↑ | IC50 (Binding - Radioligand competition/displacement) | Carbachol | Hogger P et al (1995) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => A | 7.762↓ | pK(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | >57.692↓ | K(i) (Binding - Radioligand competition/displacement) | AF-DX 116 | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 392 | ECL3 | K => A | 1.445↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 184 | ECL2 | S => A | 2.512↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 23.50x50 | 91 | ECL1 | W => A | 1.818↑ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.905↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 1.288↓ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 5.59x59 | 209 | TM5 | W => A | 1.179↑ | IC50 (Binding - Radioligand competition/displacement) | Carbachol | Hogger P et al (1995) | Vass M et al (2018) |
| acm1_human | 7.36x35 | 401 | TM7 | E => A | 2.57↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 3.32x32 | 105 | TM3 | D => E | 7.413↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 1.949↑ | pK(i) (Binding - Radioligand competition/displacement) | Himbacine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 184 | ECL2 | S => A | 2.399↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 3.28x28 | 101 | TM3 | W => F | 3.546↑ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 2.56x551 | 77 | TM2 | F => I | 1.259↓ | pK(i) (Binding - Radioligand competition/displacement) | Atropine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 183 | ECL2 | L => A | 1.548↑ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 4.65x65 | 165 | TM4 | Q => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 3.1↓ | K(i) (Binding - Radioligand competition/displacement) | Choline | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 1.23↑ | pK(i) (Binding - Radioligand competition/displacement) | Xanomeline | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 7.46x46 | 411 | TM7 | S => A | 1.5↓ | K(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 6.51x51 | 381 | TM6 | Y => A | 1.024↑ | pK(A) (Binding - Radioligand saturation) | [3H]QNB | Avlani VA et al (2010) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 19.1↓ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 34.51x51 | 131 | ICL2 | L => A | N/A | N/A | Moro O et al (1994) | ||
| acm1_human | 181 | ECL2 | Q => A | 1.047↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 174 | ECL2 | L => A | 1.023↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 2.386↓ | K(i) (Binding - Radioligand competition/displacement) | l-Hyoscyamine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | >100.0↓ | K(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 2.56x551 | 77 | TM2 | F => I | 1.862↓ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 393 | ECL3 | D => A | 1.288↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 7.36x35 | 401 | TM7 | E => A | 1.862↓ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => F | 2.95↑ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.48x48 | 378 | TM6 | W => A | 34.6↓ | K(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 6.60x60 | 390 | TM6 | F => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 3.28x28 | 101 | TM3 | W => F | 1.667↑ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | N/A | N/A | Huang XP et al (1999) | ||
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 8.13↑ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.44x44 | 374 | TM6 | F => A | 7.752↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 1.096↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 172 | ECL2 | T => A | N/A | N/A | Matsui H et al (1995) | |||
| acm1_human | 7.39x38 | 404 | TM7 | Y => F | 6.166↓ | pK(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.25↑ | K(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 171 | ECL2 | R => A | 4.169↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 182 | ECL2 | F => A | 3.02↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 3.32x32 | 105 | TM3 | D => N | 47.863↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Suga H et al (2010) | Vass M et al (2018) |
| acm1_human | 7.46x46 | 411 | TM7 | S => A | 1.5↓ | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 18.197↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.65x65 | 215 | TM5 | T => A | N/A | N/A | Lameh J et al (1992) | ||
| acm1_human | 6.32x32 | 362 | TM6 | K => A | N/A | N/A | Shockley MS et al (1997) | ||
| acm1_human | 184 | ECL2 | S => A | 1.024↑ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 23.50x50 | 91 | ECL1 | W => F | 6.166↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 17.378↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 1.429↑ | K(i) (Binding - Radioligand competition/displacement) | McN-A343 | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 772.727↓ | K(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => A | 44.668↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => F | 1.259↓ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 171 | ECL2 | R => A | 3.311↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 2.754↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 184 | ECL2 | S => A | 1.202↑ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 2.137↑ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 174 | ECL2 | L => A | 1.096↑ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 7.33x32 | 398 | TM7 | T => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 52.308↓ | K(l) (Binding - Radioligand competition/displacement) | Acetylcholine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 2.62x61 | 83 | TM2 | T => A | 1.047↑ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => A | 53.703↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 1.202↑ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.48x48 | 378 | TM6 | W => F | 1.8↓ | K(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 5.61x61 | 211 | TM5 | I => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.0 | K(i) (Binding - Radioligand competition/displacement) | Huang XP et al (1999) | Vass M et al (2018) | |
| acm1_human | 6.30x30 | 360 | TM6 | E => A | N/A | N/A | Shockley MS et al (1997) | ||
| acm1_human | 5.62x62 | 212 | TM5 | Y => A | 1.455↓ | IC50 (Binding - Radioligand competition/displacement) | Carbachol | Hogger P et al (1995) | Vass M et al (2018) |
| acm1_human | 34.51x51 | 131 | ICL2 | L => D | N/A | N/A | Moro O et al (1993) | ||
| acm1_human | 45.52x52 | 180 | ECL2 | I => A | 1.23↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 154.882↓ | pK(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 4.65x65 | 165 | TM4 | Q => A | 1.202↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 1.524↑ | K(i) (Binding - Radioligand competition/displacement) | APE | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => A | 58.884↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 184 | ECL2 | S => A | 1.0 | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 181 | ECL2 | Q => A | 1.318↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) | |
| acm1_human | 3.29x29 | 102 | TM3 | L => A | 4.365↓ | pK(A) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 181 | ECL2 | Q => A | 1.479↑ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 7.35x34 | 400 | TM7 | W => F | 9.772↓ | pK(i) (Binding - Radioligand competition/displacement) | Himbacine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 4.67x67 | 167 | TM4 | L => F | 1.95↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 5.623↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 2.62x61 | 83 | TM2 | T => A | 1.096↑ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.60x60 | 390 | TM6 | F => A | 1.318↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.37x37 | 110 | TM3 | N => A | 1.429↑ | K(i) (Binding - Radioligand competition/displacement) | McN-A343 | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.52x52 | 125 | TM3 | F => A | N/A | N/A | Moro O et al (1993) | ||
| acm1_human | 23.49x49 | 90 | ECL1 | H => A | 2.138↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 4.67x67 | 167 | TM4 | L => F | 1.024↑ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => F | 4.898↓ | pK(b) (Binding - Radioligand competition/displacement) | Benzoquinazolinone 12 | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 9.5↓ | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 2.545↓ | K(h) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => F | 10.0↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 7.762↓ | pK(A) (Binding - Radioligand saturation) | [3H]QNB | Avlani VA et al (2010) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 28.84↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 4.65x65 | 165 | TM4 | Q => A | 1.202↑ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.37x37 | 110 | TM3 | N => A | 3.8↓ | K(i) (Binding - Radioligand competition/displacement) | Arecoline | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 2.788↓ | K(l) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 6.51x51 | 381 | TM6 | Y => A | 43.652↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.44x44 | 374 | TM6 | F => A | 7.407↑ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => A | 13.804↓ | pK(i) (Binding - Radioligand competition/displacement) | Himbacine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.32x32 | 105 | TM3 | D => N | 11.749↓ | pK(i) (Binding - Radioligand competition/displacement) | McN-A343 | Suga H et al (2013) | Vass M et al (2018) |
| acm1_human | 6.32x32 | 362 | TM6 | K => A | N/A | N/A | Shockley MS et al (1997) | ||
| acm1_human | 183 | ECL2 | L => A | 1.82↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP813 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 7.51x51 | 416 | TM7 | M => A | N/A | N/A | Schlador ML et al (2000) | ||
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 4.074↓ | pK(i) (Binding - Radioligand competition/displacement) | Xanomeline | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 3.33x33 | 106 | TM3 | Y => F | 2.8↓ | K(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.21x21 | 94 | TM3 | G => A | 3.09↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.47x47 | 412 | TM7 | T => A | 1.429↑ | K(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 3.0↓ | K(i) (Binding - Radioligand competition/displacement) | CDD-0098 | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 6.51x51 | 381 | TM6 | Y => A | 20.0↑ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => A | 1.148↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.60x60 | 390 | TM6 | F => A | 1.23↑ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 16.949↑ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => F | 7.943↓ | pK(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.36x35 | 401 | TM7 | E => A | 1.585↓ | pK(i) (Binding - Radioligand competition/displacement) | Atropine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 393 | ECL3 | D => A | 1.259↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 19.231↑ | K(i) (Binding - Radioligand competition/displacement) | Arecoline | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 24.39↑ | pK(A) (Binding - Radioligand competition/displacement) | AC-42 | Avlani VA et al (2010) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.412↓ | K(i) (Binding - Radioligand competition/displacement) | Scopolamine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 45.52x52 | 180 | ECL2 | I => A | 3.09↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | 1.862↓ | pK(d) (Binding - Radioligand saturation) | [3H]QNB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => F | 1.23↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.61x61 | 211 | TM5 | I => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 97.724↓ | pK(b) (Binding - Radioligand competition/displacement) | Benzoquinazolinone 12 | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.37x37 | 110 | TM3 | N => A | 7.2↓ | K(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => F | 1.25↑ | K(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 7.47x47 | 412 | TM7 | T => A | 2.0↑ | K(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.29x29 | 102 | TM3 | L => A | 58.884↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | N/A | N/A | Huang XP et al (1999) | ||
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 10.87↑ | K(i) (Binding - Radioligand competition/displacement) | CDD-0034 | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 284 | ICL3 | S => A | N/A | N/A | Moro O et al (1993) | |||
| acm1_human | 182 | ECL2 | F => A | 1.148↑ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 181 | ECL2 | Q => A | 1.349↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 34.50x50 | 130 | ICL2 | P => A | N/A | N/A | Moro O et al (1994) | ||
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 11.482↓ | pK(i) (Binding - Radioligand competition/displacement) | (-)-N-methyl scopolamine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => A | 45.709↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => Y | 1.259↑ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 7.36x35 | 401 | TM7 | E => A | 1.096↑ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => F | 1.4↓ | K(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => A | 36.308↓ | pK(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.59x59 | 209 | TM5 | W => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 34.51x51 | 131 | ICL2 | L => A | N/A | N/A | Moro O et al (1993) | ||
| acm1_human | 7.39x38 | 404 | TM7 | Y => A | 9.772↓ | pK(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => A | 1.289↑ | pK(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 34.51x51 | 131 | ICL2 | L => M | N/A | N/A | Moro O et al (1994) | ||
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 3.333↑ | K(i) (Binding - Radioligand competition/displacement) | McN-A343 | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 171 | ECL2 | R => A | 3.021↑ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 177 | ECL2 | Q => E | 1.38↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 172 | ECL2 | T => A | 1.175↓ | pK(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 3.373↓ | K(l) (Binding - Radioligand competition/displacement) | Carbachol | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 183 | ECL2 | L => A | 1.621↑ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 6.51x51 | 381 | TM6 | Y => A | 4.785↑ | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => A | 1.445↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.38x38 | 368 | TM6 | S => A | N/A | N/A | Lameh J et al (1992) | ||
| acm1_human | 6.29x29 | 359 | TM6 | K => A | N/A | N/A | Hogger P et al (1995) | ||
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 3.236↓ | pK(A) (Binding - Radioligand competition/displacement) | Pilocarpine | Avlani VA et al (2010) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | >100.0↓ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 2.64x63 | 85 | TM2 | Y => A | N/A | N/A | Matsui H et al (1995) | ||
| acm1_human | 392 | ECL3 | K => A | 2.818↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) | |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 11000.0↓ | K(i) (Binding - Radioligand competition/displacement) | Trihexyphenidyl | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 4.69x69 | 169 | TM4 | G => A | 1.318↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 32.258↑ | pK(i) (Binding - Radioligand competition/displacement) | TBPB | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.48x48 | 378 | TM6 | W => A | 1.667↑ | K(i) (Binding - Radioligand competition/displacement) | Arecoline | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => F | 5.129↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.48x48 | 378 | TM6 | W => A | 5.0↑ | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.25↑ | K(i) (Binding - Radioligand competition/displacement) | Pilocarpine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 183 | ECL2 | L => A | 1.072↓ | pKx (Binding - Radioligand competition/displacement) | MT7 | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 8.318↓ | pK(i) (Binding - Radioligand competition/displacement) | Carbachol | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 172 | ECL2 | T => A | 1.318↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 1.15↓ | K(i) (Binding - Radioligand competition/displacement) | Choline | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 2.61x60 | 82 | TM2 | Y => A | 6.607↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 3.33x33 | 106 | TM3 | Y => A | 5.012↓ | pK(A) (Binding - Radioligand saturation) | [3H]QNB | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 23.50x50 | 91 | ECL1 | W => F | 2.042↓ | pK(i) (Binding - Radioligand competition/displacement) | Methoctramine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 3.855↓ | K(l) (Binding - Radioligand competition/displacement) | Carbachol | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 171 | ECL2 | R => A | N/A | N/A | Matsui H et al (1995) | |||
| acm1_human | 3.32x32 | 105 | TM3 | D => E | 1.0 | pK(i) (Binding - Radioligand competition/displacement) | 77-LH-28-1 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 34.51x51 | 131 | ICL2 | L => D | N/A | N/A | Moro O et al (1993) | ||
| acm1_human | 330 | ICL3 | T => A | N/A | N/A | Lameh J et al (1992) | |||
| acm1_human | 394 | ECL3 | C => A | 1.514↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) | |
| acm1_human | 34.50x50 | 130 | ICL2 | P => A | N/A | N/A | Moro O et al (1993) | ||
| acm1_human | 3.37x37 | 110 | TM3 | N => Q | 1.698↓ | pK(i) (Binding - Radioligand competition/displacement) | Tiotropium | Thal DM et al (2016) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 1.0 | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.43x43 | 116 | TM3 | L => H | N/A | N/A | Ballesteros JA et al (2001) | ||
| acm1_human | 6.58x58 | 388 | TM6 | S => Y | 1.549↓ | pK(i) (Binding - Radioligand competition/displacement) | (-)-N-methyl scopolamine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 34.56x56 | 136 | ICL2 | K => A | N/A | N/A | Moro O et al (1993) | ||
| acm1_human | 183 | ECL2 | L => A | 1.66↓ | pK(i) (Binding - Radioligand competition/displacement) | N-methyl scopolamine | Marquer C et al (2011) | Vass M et al (2018) | |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 13.2↓ | K(i) (Binding - Radioligand competition/displacement) | 4-DAMP | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.33x33 | 106 | TM3 | Y => A | 4.365↓ | pK(i) (Binding - Radioligand competition/displacement) | VCP794 | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | 3.003↑ | K(i) (Binding - Radioligand competition/displacement) | CDD-0078 | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.32x31 | 397 | TM7 | E => A | 1.479↑ | pK(b) (Binding - Radioligand competition/displacement) | BQCA | Abdul-Ridha A et al (2014) | Vass M et al (2018) |
| acm1_human | 6.52x52 | 382 | TM6 | N => A | >100.0↓ | K(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 45.51x51 | 179 | ECL2 | Y => A | 4.677↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Keov P et al (2014) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 9.7↓ | K(d) (Binding - Radioligand saturation) | [3H]N-methyl scopolamine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 1.111↑ | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.28x28 | 101 | TM3 | W => A | 23.988↓ | pK(i) (Binding - Radioligand competition/displacement) | Acetylcholine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 7.33x32 | 398 | TM7 | T => A | 1.122↓ | pK(i) (Binding - Other) | Gallamine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 5.42x43 | 192 | TM5 | T => A | 4.545↓ | K(i) (Binding - Radioligand competition/displacement) | Oxotremorine-M | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.39x38 | 404 | TM7 | Y => F | 1.122↑ | pK(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 3.33x33 | 106 | TM3 | Y => F | 1.25↑ | K(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 76.923↑ | K(l) (Binding - Radioligand competition/displacement) | Acetylcholine | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 7.35x34 | 400 | TM7 | W => F | 3.715↓ | pK(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Matsui H et al (1995) | Vass M et al (2018) |
| acm1_human | 6.48x48 | 378 | TM6 | W => F | 1.2↓ | K(i) (Binding - Radioligand competition/displacement) | Pirenzepine | Bourdon H et al (1997) | Vass M et al (2018) |
| acm1_human | 3.37x37 | 110 | TM3 | N => Q | 1.202↑ | pK(A) (Binding - Radioligand saturation) | [3H]QNB | Thal DM et al (2016) | Vass M et al (2018) |
| acm1_human | 6.59x59 | 389 | TM6 | T => P | 4.651↑ | K(i) (Binding - Radioligand competition/displacement) | Carbachol | Huang XP et al (1999) | Vass M et al (2018) |
| acm1_human | 3.37x37 | 110 | TM3 | N => A | 10.4↓ | K(i) (Binding - Radioligand competition/displacement) |