Structure information

OX2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7L1V

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-021-21087-6

PUBLICATION DATE

Feb. 10, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
compound 1 [PMID: 33547286] V114 2.64x63 TM2 hydrophobic
compound 1 [PMID: 33547286] P131 3.29x29 TM3 hydrophobic
compound 1 [PMID: 33547286] Q134 3.32x32 TM3 polar (hydrogen bond)
compound 1 [PMID: 33547286] Q134 3.32x32 TM3 polar (hydrogen bond)
compound 1 [PMID: 33547286] T135 3.33x33 TM3 Van der Waals
compound 1 [PMID: 33547286] V138 3.36x36 TM3 hydrophobic
compound 1 [PMID: 33547286] V138 3.36x36 TM3 Van der Waals
compound 1 [PMID: 33547286] Q187 4.60x61 TM4 Van der Waals
compound 1 [PMID: 33547286] M191 ECL2 Van der Waals
compound 1 [PMID: 33547286] M191 ECL2 hydrophobic
compound 1 [PMID: 33547286] C210 45.50x50 ECL2 Van der Waals
compound 1 [PMID: 33547286] F227 5.42x43 TM5 Van der Waals
compound 1 [PMID: 33547286] F227 5.42x43 TM5 aromatic (edge-to-face)
compound 1 [PMID: 33547286] I320 6.51x51 TM6 Van der Waals
compound 1 [PMID: 33547286] I320 6.51x51 TM6 hydrophobic
compound 1 [PMID: 33547286] N324 6.55x55 TM6 Van der Waals
compound 1 [PMID: 33547286] Y343 7.32x31 TM7 aromatic (face-to-edge)
compound 1 [PMID: 33547286] Y343 7.32x31 TM7 Van der Waals
compound 1 [PMID: 33547286] H350 7.39x38 TM7 aromatic (edge-to-face)
compound 1 [PMID: 33547286] H350 7.39x38 TM7 polar (hydrogen bond)
compound 1 [PMID: 33547286] H350 7.39x38 TM7 Van der Waals

Ligands

compound 1 [PMID: 33547286]

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Residue Diagrams

V N G I L A V V F V I I Y G A I L V W E 1 V N L S L A D V L V T T I C L P A T L V V 2 C S L T L V S V S V S V T Q L Y P I V K 3 A R N S I V I I W I V S C I I M I P Q 4 Y A L V M L C L P A M Y T V L F F C I H Y 5 M I V L L V F A I C Y L P I S I L N V L 6 I P N A A S N A Y V L W H S F T F W A 7
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ICL1 H H M R ICL1ECL1 T W F F ECL1ICL2 P L M F K S ICL2ECL2 E C S T V F P G L A N K T T L F T V C D E R W G G E ECL2ICL3 G T S S V V Q R K W K P L Q P V S Q P R G P G Q P T K S R M S A ICL3ECL3 G M F A H T E ECL3N-term M S G T K L E D S P P C R N W S S A S E L N E T Q E P F L N P T D Y D D E E F L R Y L W R E Y L H P K E N-termC-term G V H H R Q E D R L T R G R T S T E S R K S L T T Q I S N F D N I S K L S E Q V V L T S I S T L P A A N G A G P L Q N W C-term Y E W V L I A G Y I I V F V V A L I G N V L V C V A V W K N T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H T A K R A R N S I V I I W I V S C I I M I P Q A I V M I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C R Q I P V A A E I K Q I R A R R K T A R M L M I V L L V F A I C Y L P I S I L N V L K R V F D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C C L F R E E A F S C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OX2 receptor
TM2
2x63 2.64x63 V114
TM3
3x29 3.29x29 P131
3x32 3.32x32 Q134
3x33 3.33x33 T135
3x36 3.36x36 V138
TM4
4x61 4.60x61 Q187
ECL2
45x50 45.50x50 C210
TM5
5x43 5.42x43 F227
TM6
6x51 6.51x51 I320
6x55 6.55x55 N324
TM7
7x31 7.32x31 Y343
7x38 7.39x38 H350