Structure information

secretin receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6WZG

SPECIES

Homo sapiens

RESOLUTION

2.300

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-020-17791-4

PUBLICATION DATE

Aug. 12, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
SECRETIN L31 N-term Van der Waals
SECRETIN L31 N-term polar (hydrogen bond with backbone)
SECRETIN V125 N-term polar (hydrogen bond with backbone)
SECRETIN V125 N-term Van der Waals
SECRETIN R135 1.32x32 TM1 polar (charge-assisted hydrogen bond)
SECRETIN H136 1.33x33 TM1 Van der Waals
SECRETIN L139 1.36x36 TM1 hydrophobic
SECRETIN L139 1.36x36 TM1 Van der Waals
SECRETIN K143 1.40x40 TM1 Van der Waals
SECRETIN Y146 1.43x43 TM1 Van der Waals
SECRETIN Y146 1.43x43 TM1 aromatic (edge-to-face)
SECRETIN Y150 1.47x47 TM1 polar (hydrogen bond)
SECRETIN Y150 1.47x47 TM1 polar (hydrogen bond)
SECRETIN R188 2.60x60 TM2 polar (charge-assisted hydrogen bond)
SECRETIN N192 2.64x64 TM2 polar (hydrogen bond)
SECRETIN N192 2.64x64 TM2 polar (hydrogen bond)
SECRETIN K195 2.67x67 TM2 polar (charge-assisted hydrogen bond)
SECRETIN L199 2.71x71 TM2 polar (hydrogen bond with backbone)
SECRETIN L199 2.71x71 TM2 Van der Waals
SECRETIN F200 2.72x72 TM2 Van der Waals
SECRETIN F200 2.72x72 TM2 hydrophobic
SECRETIN S202 ECL1 polar (hydrogen bond with backbone)
SECRETIN S202 ECL1 Van der Waals
SECRETIN D203 ECL1 polar (hydrogen bond with backbone)
SECRETIN D203 ECL1 Van der Waals
SECRETIN V205 ECL1 Van der Waals
SECRETIN V205 ECL1 hydrophobic
SECRETIN F222 3.36x36 TM3 Van der Waals
SECRETIN F222 3.36x36 TM3 hydrophobic
SECRETIN Q223 3.37x37 TM3 Van der Waals
SECRETIN Q223 3.37x37 TM3 polar (hydrogen bond)
SECRETIN I226 3.40x40 TM3 hydrophobic
SECRETIN I226 3.40x40 TM3 Van der Waals
SECRETIN Y230 3.44x44 TM3 Van der Waals
SECRETIN Y230 3.44x44 TM3 hydrophobic
SECRETIN D287 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
SECRETIN I288 ECL2 Van der Waals
SECRETIN I288 ECL2 hydrophobic
SECRETIN N289 ECL2 Van der Waals
SECRETIN N289 ECL2 polar (hydrogen bond with backbone)
SECRETIN W295 5.36x37 TM5 Van der Waals
SECRETIN W295 5.36x37 TM5 aromatic (edge-to-face)
SECRETIN I298 5.39x39 TM5 Van der Waals
SECRETIN M366 7.35x34 TM7 hydrophobic
SECRETIN M366 7.35x34 TM7 Van der Waals
SECRETIN Q369 7.38x37 TM7 Van der Waals
SECRETIN L370 7.39x38 TM7 Van der Waals
SECRETIN L370 7.39x38 TM7 hydrophobic
SECRETIN E373 7.42x41 TM7 polar (charge-assisted hydrogen bond)
SECRETIN L374 7.43x42 TM7 Van der Waals
SECRETIN L374 7.43x42 TM7 hydrophobic

Ligands

SECRETIN

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Residue Diagrams

L L M V L S S S Y G V T Y M V K L K L L 1 M H L F V S F I L R A L S N F I K D A V 2 V L L W S Y N A M I C Y Q F L V M V L K 3 Y L Q G F V A G F W G S P A I F V A L W A 4 F L I F N I L I S L I V P G R I I W W I S 5 L L L I P L F G I H Y I V F A F S 6 V A V V L G Q F S G L A L E F F L Q I 7
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ICL1 R R L H ICL1ECL1 F S S D D V T Y C D A H ECL1ICL2 S F F ICL2ECL2 D V G C W D I N A ECL2ICL3 Q E T R G ICL3ECL3 P E D ECL3N-term M R P H L S P P L Q Q L L L P V L L A C A A H S T G A L P R L C D V L Q V L W E E Q D Q C L Q E L S R E Q T G D L G T E Q P V P G C E G M W D N I S C W P S S V P G R M V E V E C P R F L R M L T S R N G S L F R N C T Q D G W S E T F P R P N L A C G V N V N D S N-termC-term S F S N S T K A S H L E Q S Q G T C R T S I I C-term S N E K R H S Y L L K L K V M Y T V G Y S S S L V M L L V A L G I L C A F C T R N Y I H M H L F V S F I L R A L S N F I K D A V L R A G C K L V M V L F Q Y C I M A N Y S W L L V E G L Y L H T L L A I S E R K Y L Q G F V A F G W G S P A I F V A L W A I A R H F L E N A S I W W I I R G P V I L S I L I N F I L F I N I L R I L M R K L R T N E V S H Y K R L A R S T L L L I P L F G I H Y I V F A F S A M E I Q L F F E L A L G S F Q G L V V A V L Y C F L N G E V Q K W H L L H P V Q L E K W Q Q R E F P V A
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Residue Table


GPCRdb(A)
GPCRdb(B)
secretin receptor
TM1
1x28 1.32x32 R135
1x29 1.33x33 H136
1x32 1.36x36 L139
1x36 1.40x40 K143
1x39 1.43x43 Y146
1x43 1.47x47 Y150
TM2
2x53 2.60x60 R188
2x57 2.64x64 N192
2x60 2.67x67 K195
2x64 2.71x71 L199
TM3
3x32 3.36x36 F222
3x33 3.37x37 Q223
3x36 3.40x40 I226
3x40 3.44x44 Y230
ECL2
45x52 45.52x52 D287
TM5
5x41 5.36x37 W295
5x43 5.39x39 I298
TM7
7x30 7.35x34 M366
7x33 7.38x37 Q369
7x34 7.39x38 L370
7x37 7.42x41 E373
7x38 7.43x42 L374