Structure information

VPAC1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6VN7

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-020-17933-8

PUBLICATION DATE

Sept. 2, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
[Ac-His<sup>1</sup>]PACAP-27 D132 1.29x29 TM1 polar (hydrogen bond with backbone)
[Ac-His<sup>1</sup>]PACAP-27 D132 1.29x29 TM1 polar (charge-assisted hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 Q135 1.32x32 TM1 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 T136 1.33x33 TM1 polar (hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 Y139 1.36x36 TM1 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 Y139 1.36x36 TM1 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 V142 1.39x39 TM1 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 V142 1.39x39 TM1 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 Y146 1.43x43 TM1 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 Y146 1.43x43 TM1 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 R188 2.60x60 TM2 polar (charge-assisted hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 L199 2.71x71 TM2 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 L199 2.71x71 TM2 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 F222 3.36x36 TM3 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 F222 3.36x36 TM3 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 Q223 3.37x37 TM3 polar (hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 Q223 3.37x37 TM3 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 V226 3.40x40 TM3 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 V226 3.40x40 TM3 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 D287 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 T288 ECL2 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 I289 ECL2 polar (hydrogen bond with backbone)
[Ac-His<sup>1</sup>]PACAP-27 I289 ECL2 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 W294 5.36x37 TM5 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 W294 5.36x37 TM5 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 D362 ECL3 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 K369 7.38x37 TM7 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 M370 7.39x38 TM7 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 M370 7.39x38 TM7 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 L374 7.43x42 TM7 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 L374 7.43x42 TM7 Van der Waals

Ligands

[Ac-His<sup>1</sup>]PACAP-27

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Residue Diagrams

L L T A L S L G Y G I T Y G T K V S G Y 1 M H L F I S F I L R A A A V F I K D L A 2 V L L W F F N A M V C Y Q F F V M A A K 3 Y F W G Y I L G I W G V P S T F T M V W T 4 F L I F N V L I S T L I P G K I I W W L S 5 L L L I P L F G V H Y I M F A F F 6 I A V V F G Q F S G V V L E F V M K V 7
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ICL1 R K L H ICL1ECL1 F D S G E S D Q C S E G ECL1ICL2 S F F ICL2ECL2 D Y G C W D T I ECL2ICL3 R P P D I R K ICL3ECL3 P D N F K ECL3N-term M R P P S P L P A R W L C V L A G A L A W A L G P A G G Q A A R L Q E E C D Y V Q M I E V Q H K Q C L E E A Q L E N E T I G C S K M W D N L T C W P A T P R G Q V V V L A C P L I F K L F S S I Q G R N V S R S C T D E G W T H L E P G P Y P I A C G L D D K A N-termC-term Y R H P S G G S N G A T C S T Q V S M L T R V S P G A R R S S S F Q A E V S L V C-term A S L D E Q Q T M F Y G S V K T G Y T I G Y G L S L A T L L V A T A I L S L F C T R N Y I H M H L F I S F I L R A A A V F I K D L A L S V G C K A A M V F F Q Y C V M A N F F W L L V E G L Y L Y T L L A V S E R K Y F W G Y I L I G W G V P S T F T M V W T I A R I H F E N S S L W W I I K G P I L T S I L V N F I L F I C I I R I L L Q K L S D S S P Y S R L A R S T L L L I P L F G V H Y I M F A F F P E V K M V F E L V V G S F Q G F V V A I L Y C F L N G E L R R W H L G W N V Q A E K W R R Q G V L P K
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Residue Table


GPCRdb(A)
GPCRdb(B)
VPAC1 receptor
TM1
1x25 1.29x29 D132
1x28 1.32x32 Q135
1x29 1.33x33 T136
1x32 1.36x36 Y139
1x35 1.39x39 V142
1x39 1.43x43 Y146
TM2
2x53 2.60x60 R188
2x64 2.71x71 L199
TM3
3x32 3.36x36 F222
3x33 3.37x37 Q223
3x36 3.40x40 V226
ECL2
45x52 45.52x52 D287
TM5
5x41 5.36x37 W294
TM7
7x33 7.38x37 K369
7x34 7.39x38 M370
7x38 7.43x42 L374