Structure information

calcitonin receptor-like receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6UUS

SPECIES

Homo sapiens

RESOLUTION

2.400

PREFERRED CHAIN

R

PUBLICATION DATE

April 1, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
adrenomedullin W72 N-term aromatic (face-to-edge)
adrenomedullin F92 N-term hydrophobic
adrenomedullin Q93 N-term polar (hydrogen bond)
adrenomedullin Q93 N-term polar (hydrogen bond)
adrenomedullin Q93 N-term polar (hydrogen bond with backbone)
adrenomedullin P97 N-term hydrophobic
adrenomedullin S117 N-term polar (hydrogen bond)
adrenomedullin W121 N-term polar (hydrogen bond)
adrenomedullin Y124 N-term hydrophobic
adrenomedullin N128 N-term polar (charge-assisted hydrogen bond)
adrenomedullin V135 1.33x33 TM1 hydrophobic
adrenomedullin F142 1.40x40 TM1 hydrophobic
adrenomedullin L195 2.68x68 TM2 hydrophobic
adrenomedullin A199 ECL1 polar (hydrogen bond with backbone)
adrenomedullin Q202 ECL1 polar (hydrogen bond)
adrenomedullin Q202 ECL1 polar (hydrogen bond)
adrenomedullin V205 ECL1 hydrophobic
adrenomedullin Q216 3.33x33 TM3 polar (hydrogen bond)
adrenomedullin I284 45.52x52 ECL2 hydrophobic
adrenomedullin S286 ECL2 polar (hydrogen bond with backbone)
adrenomedullin S286 ECL2 polar (hydrogen bond)
adrenomedullin L291 5.36x37 TM5 hydrophobic
adrenomedullin Y292 5.37x38 TM5 polar (hydrogen bond)
adrenomedullin H295 5.40x40 TM5 polar (hydrogen bond)
adrenomedullin F349 6.53x53 TM6 hydrophobic

Ligands

adrenomedullin

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Residue Diagrams

L L S A I S L G H G I I T L Y F L N L A 1 K N L F F S F V C N S V V T I I H L T A 2 C L M W F Y N C G M L Y L H I F Q S V K 3 H L M W Y Y F G L W G F P L I P A C I H A 4 L F F L N V L L A A C I P G H I I Y L L 5 L I L V P L L G I E F V L I P W 6 T S V L L G Q F H M L I H M I Y D Y V 7
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ICL1 K S L S ICL1ECL1 A N N Q A L V A T N P ECL1ICL2 A V F A E K Q ICL2ECL2 Y N D N C W I S S D T H ECL2ICL3 V T H Q A E S N L ICL3ECL3 R P E G ECL3N-term M E K K C T L N F L V L L P F F M I L V T A E L E E S P E D S I Q L G V T R N K I M T A Q Y E C Y Q K I M Q D P I Q Q A E G V Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D Q D G N W F R H P A S N R T W T N Y T Q C N V N-termC-term E A L R S A S Y T V S T I S D G P G Y S H D C P S E H L N G K S I H D I E N V L L K P E N L Y N C-term N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F C Q R I T L H K N L F F S F V C N S V V T I I H L T A V V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K L K Y M K A V R A T L I L V P L L G I E F V L I P W K I A E E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E L R R Y K I S F S V Q A I N W N Q Q F G N N S
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Residue Table


GPCRdb(A)
GPCRdb(B)
calcitonin receptor-like receptor
TM1
1x29 1.33x33 V135
1x36 1.40x40 F142
TM2
2x61 2.68x68 L195
TM3
3x29 3.33x33 Q216
ECL2
45x52 45.52x52 I284
TM5
5x41 5.36x37 L291
5x42 5.37x38 Y292
5x44 5.40x40 H295
TM6
6x48 6.53x53 F349