Structure information

OT receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6TPK

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIADV.ABB5419

PUBLICATION DATE

Aug. 5, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
retosiban K116 3.29x29 TM3 polar (charge-assisted hydrogen bond)
retosiban Q119 3.32x32 TM3 polar (hydrogen bond)
retosiban M123 3.36x36 TM3 hydrophobic
retosiban M123 3.36x36 TM3 Van der Waals
retosiban Q171 4.60x61 TM4 Van der Waals
retosiban Q171 4.60x61 TM4 polar (hydrogen bond)
retosiban F175 4.64x65 TM4 Van der Waals
retosiban I201 5.39x40 TM5 Van der Waals
retosiban I201 5.39x40 TM5 hydrophobic
retosiban W288 6.48x48 TM6 hydrophobic
retosiban W288 6.48x48 TM6 Van der Waals
retosiban F291 6.51x51 TM6 hydrophobic
retosiban F291 6.51x51 TM6 Van der Waals
retosiban Q295 6.55x55 TM6 Van der Waals
retosiban Q295 6.55x55 TM6 polar (hydrogen bond)
retosiban A318 7.42x41 TM7 Van der Waals
retosiban A318 7.42x41 TM7 hydrophobic

Ligands

retosiban

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Residue Diagrams

A N G S L A L L L I L C L V A V E V R A 1 K H L S I A D L V V A F V Q V L P Q L L W 2 L L L L Y T S A F M G V V Q L Y K V L R 3 D R L A V L A T W L G C L V A S A P Q 4 Y C A A L V I V P V I Y V A L T I W T I Y 5 F I I V L A F I V C W T P F F F V Q M W 6 W P N C C S N L S A L L M V I I F A S 7
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ICL1 R Q K H ICL1ECL1 R F Y G ECL1ICL2 P L R S L ICL2ECL2 S L R E V A D G V F D C W A V F I Q P ECL2ICL3 A A A E A P E G A A A G D G G R V A L A R V S S V ICL3ECL3 D A N A P ECL3N-term M E G A L A A N W S A E A A N A S A A P P G A E G N R T A G P P R R N-termC-term S Y L K G R R L G E T S A S K K S N S S S F V L S H R S S S Q R S C S Q P S T A C-term N E A L A R V E V A V L C L I L L L A L S G N A C V L L A L R T T S R L F F F M K H L S I A D L V V A V F Q V L P Q L L W D I T F P D L L C R L V K Y L Q V V G M F A S T Y L L L L M S L D R C L A I C Q R R R T D R L A V L A T W L G C L V A S A P Q V H I F W G P K A Y I T W I T L A V Y I V P V I V L A A C Y G L I S F K I W Q N L R L K T A A A K L I S K A K I R T V K M T F I I V L A F I V C W T P F F F V Q M W S V W K E A S A F I I V M L L A S L N S C C N P W I Y M L F T G H L V Q C S A L F H E R F L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OT receptor
TM3
3x29 3.29x29 K116
3x32 3.32x32 Q119
3x36 3.36x36 M123
TM4
4x61 4.60x61 Q171
4x65 4.64x65 F175
TM5
5x40 5.39x40 I201
TM6
6x48 6.48x48 W288
6x51 6.51x51 F291
6x55 6.55x55 Q295
TM7
7x41 7.42x41 A318