Structure information

OX1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6TO7

SPECIES

Homo sapiens

RESOLUTION

2.260

PREFERRED CHAIN

A

REFERENCE

10.1021/acs.jmedchem.9b01787

PUBLICATION DATE

Jan. 1, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
suvorexant A102 2.60x59 TM2 hydrophobic
suvorexant W112 23.50x50 ECL1 hydrophobic
suvorexant I122 3.28x28 TM3 hydrophobic
suvorexant P123 3.29x29 TM3 hydrophobic
suvorexant V130 3.36x36 TM3 hydrophobic
suvorexant F219 5.42x43 TM5 aromatic (edge-to-face)
suvorexant I314 6.51x51 TM6 hydrophobic
suvorexant N318 6.55x55 TM6 polar (hydrogen bond)
suvorexant N318 6.55x55 TM6 Van der Waals
suvorexant H344 7.39x38 TM7 Van der Waals
suvorexant H344 7.39x38 TM7 aromatic (face-to-face)
suvorexant V347 7.42x41 TM7 Van der Waals
suvorexant V347 7.42x41 TM7 hydrophobic
suvorexant Y348 7.43x42 TM7 Van der Waals
suvorexant Y348 7.43x42 TM7 hydrophobic

Ligands

suvorexant

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Residue Diagrams

T N G V L A V V F V A V Y A A I L V W E 1 V N L S L A D V L V T I A C L P A S L L V 2 F S L T L V A V S V S V A Q L Y P I V K 3 A R G S I L G I W A V S L A I M V P Q 4 Y A M A M L G L P A L Y T V I F F C S H Y 5 M V V L L V F A L C Y L P I S V L N V L 6 I P N A A S N A Y V L W H S F T F C A 7
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ICL1 H H M R ICL1ECL1 S W L F ECL1ICL2 P L L F K S ICL2ECL2 E C S S V L P E L A N R T R L F S V C D E R W A D D ECL2ICL3 G T T S A L V R N W K R P S D Q L G D L E Q G L S G E P Q P R A R A ICL3ECL3 G M F R Q A S ECL3N-term M E P S A T P G A Q M G V P P G S R E P S P V P P D Y E D E F L R Y L W R D Y L Y P K Q Y N-termC-term G L G P C G S L K A P S P R S S A S H K S L S L Q S R C S I S K I S E H V V L T S V T T V L P C-term E W V L I A A Y V A V F V V A L V G N T L V C L A V W R N T V T N Y F I V N L S L A D V L V T A I C L P A S L L V D I T E G H A L C K V I P Y L Q A V S V S V A V L T L S F I A L D R W Y A I C H T A R R A R G S I L G I W A V S L A I M V P Q A A V M L Y P K I Y H S C F F I V T Y L A P L G L M A M A Y F Q I F R K L W G R Q I P F L A E V K Q M R A R R K T A K M L M V V L L V F A L C Y L P I S V L N V L K R V F D R E A V Y A C F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C L P F R E Q A F S C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OX1 receptor
TM2
2x59 2.60x59 A102
ECL1
23x50 23.50x50 W112
TM3
3x28 3.28x28 I122
3x29 3.29x29 P123
3x36 3.36x36 V130
TM5
5x43 5.42x43 F219
TM6
6x51 6.51x51 I314
6x55 6.55x55 N318
TM7
7x38 7.39x38 H344
7x41 7.42x41 V347
7x42 7.43x42 Y348