Structure information

AT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6OS1

SPECIES

Homo sapiens

RESOLUTION

2.790

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIENCE.AAY9813

PUBLICATION DATE

Feb. 19, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
TRV023 Q15 N-term polar (hydrogen bond with backbone)
TRV023 Q15 N-term Van der Waals
TRV023 D16 N-term Van der Waals
TRV023 D17 N-term Van der Waals
TRV023 D17 N-term polar (hydrogen bond with backbone)
TRV023 W84 2.60x60 TM2 Van der Waals
TRV023 W84 2.60x60 TM2 hydrophobic
TRV023 Y87 2.63x63 TM2 polar (hydrogen bond)
TRV023 Y87 2.63x63 TM2 Van der Waals
TRV023 Y92 ECL1 hydrophobic
TRV023 Y92 ECL1 Van der Waals
TRV023 V108 3.32x32 TM3 Van der Waals
TRV023 V108 3.32x32 TM3 hydrophobic
TRV023 S109 3.33x33 TM3 Van der Waals
TRV023 R167 ECL2 polar (charge-assisted hydrogen bond)
TRV023 A181 45.51x51 ECL2 Van der Waals
TRV023 A181 45.51x51 ECL2 hydrophobic
TRV023 F182 45.52x52 ECL2 Van der Waals
TRV023 F182 45.52x52 ECL2 polar (hydrogen bond with backbone)
TRV023 H183 ECL2 polar (hydrogen bond)
TRV023 Y184 ECL2 polar (hydrogen bond with backbone)
TRV023 Y184 ECL2 Van der Waals
TRV023 K199 5.42x43 TM5 polar (charge-assisted hydrogen bond)
TRV023 H1256 6.51x51 TM6 Van der Waals
TRV023 D1263 6.58x58 TM6 polar (charge-assisted hydrogen bond)
TRV023 I1266 6.61x61 TM6 Van der Waals
TRV023 D1281 7.32x31 TM7 polar (charge-assisted hydrogen bond)
TRV023 M1284 7.35x34 TM7 hydrophobic
TRV023 M1284 7.35x34 TM7 Van der Waals
TRV023 P1285 7.36x35 TM7 Van der Waals
TRV023 I1288 7.39x38 TM7 Van der Waals
TRV023 I1288 7.39x38 TM7 hydrophobic

Ligands

TRV023

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Residue Diagrams

S N G F I G V V F I I S Y L T P I M V F 1 L N L A L A D L C F L L T L P L W A V Y 2 C T L L F V S A Y L N F S V S A S A I K 3 A K V T C I I I W L L A G L A S L P A 4 Y S T L I I L F P F L F G L I N K T L G L 5 M A I V L F F F F S W I P H Q I F T F L 6 L P N L C N N F Y A I C I T I P M A T 7
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ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
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Residue Table


GPCRdb(A)
GPCRdb(A)
AT1 receptor
TM2
2x60 2.60x60 W84
2x63 2.63x63 Y87
TM3
3x32 3.32x32 V108
3x33 3.33x33 S109
ECL2
45x51 45.51x51 A181
45x52 45.52x52 F182
TM5
5x43 5.42x43 K199
TM6
6x51 6.51x51 H256
6x58 6.58x58 D263
6x61 6.61x61 I266
TM7
7x31 7.32x31 D281
7x34 7.35x34 M284
7x35 7.36x35 P285
7x38 7.39x38 I288