Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6NBH

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

R

PUBLICATION DATE

April 17, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Long-acting parathyroid hormone analog V31 N-term hydrophobic
Long-acting parathyroid hormone analog I115 N-term hydrophobic
Long-acting parathyroid hormone analog D137 N-term polar (charge-assisted hydrogen bond)
Long-acting parathyroid hormone analog F138 N-term hydrophobic
Long-acting parathyroid hormone analog R162 N-term polar (charge-charge)
Long-acting parathyroid hormone analog W164 N-term polar (hydrogen bond)
Long-acting parathyroid hormone analog A165 N-term polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog A165 N-term polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog Y167 N-term hydrophobic
Long-acting parathyroid hormone analog L174 N-term hydrophobic
Long-acting parathyroid hormone analog T175 N-term polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog F184 1.36x36 TM1 aromatic (edge-to-face)
Long-acting parathyroid hormone analog Y195 1.47x47 TM1 polar (charge-assisted hydrogen bond)
Long-acting parathyroid hormone analog R233 2.60x60 TM2 polar (charge-charge)
Long-acting parathyroid hormone analog K240 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Long-acting parathyroid hormone analog F288 3.36x36 TM3 hydrophobic
Long-acting parathyroid hormone analog L292 3.40x40 TM3 hydrophobic
Long-acting parathyroid hormone analog D353 45.52x52 ECL2 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog L354 ECL2 hydrophobic
Long-acting parathyroid hormone analog S355 ECL2 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog Q364 5.40x40 TM5 polar (hydrogen bond)
Long-acting parathyroid hormone analog M425 ECL3 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog T427 ECL3 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog Y429 ECL3 hydrophobic
Long-acting parathyroid hormone analog M441 7.39x38 TM7 hydrophobic
Long-acting parathyroid hormone analog M445 7.43x42 TM7 hydrophobic

Ligands

Long-acting parathyroid hormone analog

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Residue Diagrams

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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x32 1.36x36 F184
1x43 1.47x47 Y195
TM2
2x53 2.60x60 R233
2x60 2.67x67 K240
TM3
3x32 3.36x36 F288
3x36 3.40x40 L292
ECL2
45x52 45.52x52 D353
TM5
5x44 5.40x40 Q364
TM7
7x34 7.39x38 M441
7x38 7.43x42 M445