Structure information

EP3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6M9T

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

REFERENCE

10.1038/S41589-018-0160-Y

PUBLICATION DATE

Dec. 5, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Misoprostol-FA Y114 2.65x65 TM2 polar (hydrogen bond)
Misoprostol-FA Y114 2.65x65 TM2 Van der Waals
Misoprostol-FA M137 3.32x32 TM3 Van der Waals
Misoprostol-FA M137 3.32x32 TM3 hydrophobic
Misoprostol-FA F140 3.35x35 TM3 hydrophobic
Misoprostol-FA F140 3.35x35 TM3 Van der Waals
Misoprostol-FA T206 ECL2 Van der Waals
Misoprostol-FA T206 ECL2 polar (hydrogen bond)
Misoprostol-FA W207 ECL2 Van der Waals
Misoprostol-FA W207 ECL2 hydrophobic
Misoprostol-FA F209 45.51x51 ECL2 Van der Waals
Misoprostol-FA W295 6.48x48 TM6 hydrophobic
Misoprostol-FA W295 6.48x48 TM6 Van der Waals
Misoprostol-FA L329 7.36x35 TM7 Van der Waals
Misoprostol-FA L329 7.36x35 TM7 hydrophobic
Misoprostol-FA V332 7.39x38 TM7 hydrophobic
Misoprostol-FA V332 7.39x38 TM7 Van der Waals
Misoprostol-FA R333 7.40x39 TM7 polar (charge-assisted hydrogen bond)
Misoprostol-FA S336 7.43x42 TM7 Van der Waals
Misoprostol-FA Q339 7.46x46 TM7 Van der Waals
Misoprostol-FA Q339 7.46x46 TM7 polar (hydrogen bond)

Ligands

Misoprostol-FA

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Residue Diagrams

A N G V F G T L L M T I P F A V 1 G W L A L T D L V G Q L L T T P V V I V 2 A S A I F L S S L G F V T M T L G F F T 3 T R A V L L G V W L A V L A F A L L P V 4 N C S F T V T L A L L G L F A F A S A F 5 M G I M C V L S V C W S P L L I M M L K 6 W P D L I Q N L S A L R V A I L F F N 7
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ICL1 R R E S K R ICL1ECL1 Q R W E H I D P S ECL1ICL2 P H W Y A S H M ICL2ECL2 V G Q Y T V Q W P G T W C F I S T G R G G N G T S S S H N ECL2ICL3 T A S Q ICL3ECL3 V E H C K ECL3N-term M K E T R G Y G G D A P F C T R L N H S Y T G M W A P E R S A E A R G N L T R P P G S G E D C G S V S N-termC-term S S T S L P C Q C S S T L M W S D H L E R C-term V A F P I T M L L T G F V G N A L A M L L V S R S Y R K K S F L L C I G W L A L T D L V G Q L L T T P V V I V V Y L S K G R L C T F F G L T M T V F G L S S L F I A S A M A V E R A L A I R A K T R A T R A V L L G V W L A V L A F A L L P V L G W G N L F F A S A F A F L G L L A L T V T F S C N L A T I K A L V S R C R A K A S S A Q W G R I T T E T A I Q L M G I M C V L S V C W S P L L I M M L K M I F N Q T S T H T E K Q K E C N F F L I A V R L A S L N Q I L D P W V Y L L L R K I F C Q T N N L L R K I R Y H Y A S
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP3 receptor
TM2
2x65 2.65x65 Y114
TM3
3x32 3.32x32 M137
3x35 3.35x35 F140
ECL2
45x51 45.51x51 F209
TM6
6x48 6.48x48 W295
TM7
7x35 7.36x35 L329
7x38 7.39x38 V332
7x39 7.40x39 R333
7x42 7.43x42 S336
7x46 7.46x46 Q339