Structure information

CB2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6KPF

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2020.01.008

PUBLICATION DATE

Feb. 12, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AM12033 F87 2.57x57 TM2 hydrophobic
AM12033 F91 2.61x61 TM2 hydrophobic
AM12033 F94 2.64x64 TM2 hydrophobic
AM12033 I110 3.29x29 TM3 hydrophobic
AM12033 V113 3.32x32 TM3 hydrophobic
AM12033 F117 3.36x36 TM3 hydrophobic
AM12033 F183 ECL2 hydrophobic
AM12033 P184 ECL2 hydrophobic
AM12033 W194 5.43x43 TM5 hydrophobic
AM12033 W258 6.48x48 TM6 hydrophobic
AM12033 S285 7.39x38 TM7 Van der Waals
AM12033 S285 7.39x38 TM7 polar (hydrogen bond)
AM12033 C288 7.42x41 TM7 Van der Waals

Ligands

AM12033

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Residue Diagrams

V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7
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ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x57 2.57x57 F87
2x61 2.61x61 F91
2x64 2.64x64 F94
TM3
3x29 3.29x29 I110
3x32 3.32x32 V113
3x36 3.36x36 F117
TM5
5x43 5.43x43 W194
TM6
6x48 6.48x48 W258
TM7
7x38 7.39x38 S285
7x41 7.42x41 C288