Structure information

TP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6IIU

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

REFERENCE

10.1038/S41589-018-0170-9

PUBLICATION DATE

Dec. 19, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ramatroban A31 1.39x39 TM1 hydrophobic
ramatroban F34 1.42x42 TM1 hydrophobic
ramatroban L78 2.54x54 TM2 polar (hydrogen bond with backbone)
ramatroban L78 2.54x54 TM2 Van der Waals
ramatroban T81 2.57x57 TM2 polar (hydrogen bond)
ramatroban T81 2.57x57 TM2 polar (hydrogen bond)
ramatroban V85 2.61x61 TM2 hydrophobic
ramatroban V85 2.61x61 TM2 Van der Waals
ramatroban H89 2.65x65 TM2 polar (hydrogen bond)
ramatroban H89 2.65x65 TM2 Van der Waals
ramatroban M112 3.32x32 TM3 Van der Waals
ramatroban M112 3.32x32 TM3 polar (hydrogen bond with backbone)
ramatroban F115 3.35x35 TM3 Van der Waals
ramatroban F115 3.35x35 TM3 hydrophobic
ramatroban G116 3.36x36 TM3 Van der Waals
ramatroban S181 ECL2 Van der Waals
ramatroban S181 ECL2 polar (hydrogen bond)
ramatroban W258 6.48x48 TM6 Van der Waals
ramatroban W258 6.48x48 TM6 hydrophobic
ramatroban L291 7.36x35 TM7 Van der Waals
ramatroban L294 7.39x38 TM7 hydrophobic
ramatroban L294 7.39x38 TM7 Van der Waals
ramatroban R295 7.40x39 TM7 polar (charge-assisted hydrogen bond)
ramatroban T298 7.43x42 TM7 Van der Waals
ramatroban Q301 7.46x46 TM7 polar (hydrogen bond)
ramatroban Q301 7.46x46 TM7 Van der Waals

Ligands

ramatroban

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Residue Diagrams

L N S A L G V V C F S A A F W P S 1 C G L V L T D F L G L L V T G T I V V S 2 A A G L L L P S L G F F I M V V G M F R 3 A W A T V G L V W A A A L A L G L L P L 4 N L L F S L G V S L G G L M S F L L G F 5 L G I M V V A S V C W L P L L V F I A Q 6 W P D L I Q N W T A V R L Y I L L E K 7
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ICL1 G G S H T R ICL1ECL1 L F E W H A V D P G ECL1ICL2 P F S R P A V A ICL2ECL2 V G R Y T V Q Y P G S W C F L T L G A ECL2ICL3 E A A Q ICL3ECL3 N P P A M S P A G Q L ECL3N-term M W P N G S S L G P C F R P T N I T L E E R R L I A N-termC-term L Q P Q L T Q R S G L Q C-term S P W F A A S F C V V G L A S N L L A L S V L A G A R Q S S F L T F L C G L V L T D F L G L L V T G T I V V S Q H A A C R L C R F M G V V M I F F G L S P L L L G A A M A S E R Y L G I T R S Q R R A W A T V G L V W A A A L A L G L L P L L G E S G D V A F G L L F S M L G G L S V G L S F L L N T V S V A T L C H V Y H G Q Q R P R D S E V E M M A Q L L G I M V V A S V C W L P L L V F I A Q T V L R S R T T E K E L L I Y L R V A T W N Q I L D P W V Y I L F R R A L Q P R P R V L R R R L S T S L S
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Residue Table


GPCRdb(A)
GPCRdb(A)
TP receptor
TM1
1x39 1.39x39 A31
1x42 1.42x42 F34
TM2
2x54 2.54x54 L78
2x57 2.57x57 T81
2x61 2.61x61 V85
2x65 2.65x65 H89
TM3
3x32 3.32x32 M112
3x35 3.35x35 F115
3x36 3.36x36 G116
TM6
6x48 6.48x48 W258
TM7
7x35 7.36x35 L291
7x38 7.39x38 L294
7x39 7.40x39 R295
7x42 7.43x42 T298
7x46 7.46x46 Q301