Structure information

ETB receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6IGK

SPECIES

Homo sapiens

RESOLUTION

2.000

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-018-07094-0

PUBLICATION DATE

Nov. 21, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
endothelin-3 S86 N-term polar (hydrogen bond)
endothelin-3 P87 N-term polar (hydrogen bond with backbone)
endothelin-3 P87 N-term Van der Waals
endothelin-3 P88 N-term Van der Waals
endothelin-3 P89 N-term Van der Waals
endothelin-3 P89 N-term hydrophobic
endothelin-3 C90 N-term polar (hydrogen bond with backbone)
endothelin-3 C90 N-term Van der Waals
endothelin-3 I94 N-term hydrophobic
endothelin-3 I94 N-term Van der Waals
endothelin-3 N158 2.61x60 TM2 polar (hydrogen bond)
endothelin-3 K161 2.64x63 TM2 polar (charge-assisted hydrogen bond)
endothelin-3 E165 2.68x67 TM2 polar (hydrogen bond with backbone)
endothelin-3 E165 2.68x67 TM2 Van der Waals
endothelin-3 Q181 3.32x32 TM3 polar (hydrogen bond)
endothelin-3 Q181 3.32x32 TM3 Van der Waals
endothelin-3 K182 3.33x33 TM3 polar (charge-assisted hydrogen bond)
endothelin-3 E236 4.60x61 TM4 polar (charge-assisted hydrogen bond)
endothelin-3 F240 4.64x65 TM4 Van der Waals
endothelin-3 I243 ECL2 Van der Waals
endothelin-3 I243 ECL2 hydrophobic
endothelin-3 M245 ECL2 hydrophobic
endothelin-3 M245 ECL2 Van der Waals
endothelin-3 D246 ECL2 Van der Waals
endothelin-3 D246 ECL2 polar (hydrogen bond with backbone)
endothelin-3 Y247 ECL2 aromatic (face-to-face)
endothelin-3 Y247 ECL2 polar (hydrogen bond)
endothelin-3 Y247 ECL2 Van der Waals
endothelin-3 K248 ECL2 polar (charge-assisted hydrogen bond)
endothelin-3 L252 ECL2 Van der Waals
endothelin-3 L252 ECL2 hydrophobic
endothelin-3 R253 ECL2 Van der Waals
endothelin-3 I254 ECL2 hydrophobic
endothelin-3 I254 ECL2 Van der Waals
endothelin-3 L256 45.51x51 ECL2 Van der Waals
endothelin-3 L256 45.51x51 ECL2 hydrophobic
endothelin-3 L257 45.52x52 ECL2 Van der Waals
endothelin-3 L257 45.52x52 ECL2 polar (hydrogen bond with backbone)
endothelin-3 H258 ECL2 Van der Waals
endothelin-3 H258 ECL2 polar (hydrogen bond)
endothelin-3 P259 ECL2 polar (hydrogen bond with backbone)
endothelin-3 P259 ECL2 Van der Waals
endothelin-3 V260 ECL2 hydrophobic
endothelin-3 V260 ECL2 Van der Waals
endothelin-3 K273 5.38x39 TM5 polar (charge-assisted hydrogen bond)
endothelin-3 D274 5.39x40 TM5 polar (charge-assisted hydrogen bond)
endothelin-3 L277 5.42x43 TM5 Van der Waals
endothelin-3 W336 6.48x48 TM6 Van der Waals
endothelin-3 W336 6.48x48 TM6 hydrophobic
endothelin-3 L339 6.51x51 TM6 Van der Waals
endothelin-3 L339 6.51x51 TM6 hydrophobic
endothelin-3 R343 6.55x55 TM6 polar (charge-assisted hydrogen bond)
endothelin-3 K346 6.58x58 TM6 polar (charge-assisted hydrogen bond)
endothelin-3 Y350 6.62x62 TM6 polar (hydrogen bond)
endothelin-3 Y350 6.62x62 TM6 Van der Waals
endothelin-3 Q352 ECL3 polar (hydrogen bond)
endothelin-3 R357 7.24x23 TM7 polar (charge-assisted hydrogen bond)
endothelin-3 C358 7.25x24 TM7 Van der Waals
endothelin-3 L361 7.28x27 TM7 hydrophobic
endothelin-3 L361 7.28x27 TM7 Van der Waals
endothelin-3 L364 7.31x30 TM7 hydrophobic
endothelin-3 L364 7.31x30 TM7 Van der Waals
endothelin-3 L365 7.32x31 TM7 Van der Waals
endothelin-3 L365 7.32x31 TM7 hydrophobic
endothelin-3 D368 7.35x34 TM7 polar (charge-assisted hydrogen bond)
endothelin-3 Y369 7.36x35 TM7 polar (hydrogen bond)
endothelin-3 Y369 7.36x35 TM7 Van der Waals
endothelin-3 I372 7.39x38 TM7 Van der Waals
endothelin-3 I372 7.39x38 TM7 hydrophobic

Ligands

endothelin-3

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Residue Diagrams

S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7
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ICL1 K C M R N ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
ETB receptor
TM2
2x60 2.61x60 N158
2x63 2.64x63 K161
TM3
3x32 3.32x32 Q181
3x33 3.33x33 K182
TM4
4x61 4.60x61 E236
4x65 4.64x65 F240
ECL2
45x51 45.51x51 L256
45x52 45.52x52 L257
TM5
5x39 5.38x39 K273
5x40 5.39x40 D274
5x43 5.42x43 L277
TM6
6x48 6.48x48 W336
6x51 6.51x51 L339
6x55 6.55x55 R343
6x58 6.58x58 K346
6x62 6.62x62 Y350
TM7
7x23 7.24x23 R357
7x24 7.25x24 C358
7x27 7.28x27 L361
7x30 7.31x30 L364
7x31 7.32x31 L365
7x34 7.35x34 D368
7x35 7.36x35 Y369
7x38 7.39x38 I372