Structure information

β1-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6H7O

SPECIES

Meleagris gallopavo

RESOLUTION

2.800

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIENCE.AAU5595

PUBLICATION DATE

Oct. 17, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(S)-Cyanopindolol D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
(S)-Cyanopindolol D121 3.32x32 TM3 polar (charge-charge)
(S)-Cyanopindolol V122 3.33x33 TM3 hydrophobic
(S)-Cyanopindolol F201 45.52x52 ECL2 aromatic (edge-to-face)
(S)-Cyanopindolol S211 5.42x43 TM5 polar (hydrogen bond)
(S)-Cyanopindolol F306 6.51x51 TM6 hydrophobic
(S)-Cyanopindolol F307 6.52x52 TM6 aromatic (edge-to-face)
(S)-Cyanopindolol N329 7.39x38 TM7 polar (charge-assisted hydrogen bond)
(S)-Cyanopindolol N329 7.39x38 TM7 polar (hydrogen bond)
(S)-Cyanopindolol N329 7.39x38 TM7 polar (hydrogen bond)
(S)-Cyanopindolol Y333 7.43x42 TM7 polar (hydrogen bond)

Ligands

(S)-Cyanopindolol

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Residue Diagrams

V N G A V I L L V V L A M L L S M G A E 1 T S L A C A D L V M G L L V V P F G A T L 2 V C L T E I S A T V C L V D L S T W C E 3 A K V I I C T V W A I S A L V S F L P I 4 Y V F I M I L L P I Y F S I I S S A I A Y 5 G I I M G V F T L C W L P F F L V N I V 6 I P N F A S N A Y G L W N F F V F L W 7
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ICL1 Q R L Q ICL1ECL1 T W L W ECL1ICL2 P F R Y Q S L M ICL2ECL2 W W R D E D P Q A L K C Y Q D P G C C D F V T ECL2ICL3 G R F Y G S Q E Q P Q P P P L P Q H Q P I L G N G R A S K ICL3ECL3 R D L V ECL3N-term M G D G W L P P D C G P H N R S G G G G A T A A P T G S R Q V S N-termC-term F P R K A D R R L H A G G Q P A P L P G G F I S T L G S P E H S P G G T W S D C N G G T R G G S E S S L E E R H S K T S R S E S K M E R E K N I L A T T R F Y C T F L G N G D K A V F C T V L R I V K L F E D A T C T C P H T H K L K M K W R F K Q H Q A C-term A E L L S Q Q W E A G M S L L M A L V V L L I V A G N V L V I A A I G R T T L T N L F I T S L A C A D L V M G L L V V P F G A T L V V R G G S F L C E C W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S T R A R A K V I I C T V W A I S A L V S F L P I M M H N R A Y A I A S S I I S F Y I P L L I M I F V Y L R V Y R E A K E Q I R K I D R C E R K T S R V M A M R E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N P D W L F V F F N W L G Y A N S A F N P I I Y C R S P D F K R F R K A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β1-adrenoceptor
TM3
3x32 3.32x32 D121
3x33 3.33x33 V122
ECL2
45x52 45.52x52 F201
TM5
5x43 5.42x43 S211
TM6
6x51 6.51x51 F306
6x52 6.52x52 F307
TM7
7x38 7.39x38 N329
7x42 7.43x42 Y333