Structure information

AT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6DO1

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

A

REFERENCE

10.1016/J.CELL.2018.12.006

PUBLICATION DATE

Jan. 30, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL404594 Q15 N-term Van der Waals
CHEMBL404594 Q15 N-term polar (hydrogen bond with backbone)
CHEMBL404594 D16 N-term polar (charge-assisted hydrogen bond)
CHEMBL404594 D17 N-term polar (charge-assisted hydrogen bond)
CHEMBL404594 D17 N-term polar (hydrogen bond with backbone)
CHEMBL404594 R23 N-term Van der Waals
CHEMBL404594 W84 2.60x60 TM2 Van der Waals
CHEMBL404594 W84 2.60x60 TM2 hydrophobic
CHEMBL404594 Y87 2.63x63 TM2 Van der Waals
CHEMBL404594 Y92 ECL1 Van der Waals
CHEMBL404594 Y92 ECL1 hydrophobic
CHEMBL404594 V108 3.32x32 TM3 Van der Waals
CHEMBL404594 V108 3.32x32 TM3 hydrophobic
CHEMBL404594 L112 3.36x36 TM3 Van der Waals
CHEMBL404594 L112 3.36x36 TM3 hydrophobic
CHEMBL404594 R167 4.64x65 TM4 polar (charge-assisted hydrogen bond)
CHEMBL404594 C180 45.50x50 ECL2 Van der Waals
CHEMBL404594 A181 45.51x51 ECL2 hydrophobic
CHEMBL404594 A181 45.51x51 ECL2 Van der Waals
CHEMBL404594 F182 45.52x52 ECL2 polar (hydrogen bond with backbone)
CHEMBL404594 F182 45.52x52 ECL2 Van der Waals
CHEMBL404594 H183 ECL2 polar (hydrogen bond)
CHEMBL404594 Y184 ECL2 Van der Waals
CHEMBL404594 Y184 ECL2 polar (hydrogen bond with backbone)
CHEMBL404594 K199 5.42x43 TM5 polar (charge-assisted hydrogen bond)
CHEMBL404594 H355 6.51x51 TM6 Van der Waals
CHEMBL404594 D362 6.58x58 TM6 polar (charge-assisted hydrogen bond)
CHEMBL404594 D380 7.32x31 TM7 polar (charge-assisted hydrogen bond)
CHEMBL404594 M383 7.35x34 TM7 polar (hydrogen bond)
CHEMBL404594 P384 7.36x35 TM7 Van der Waals
CHEMBL404594 I387 7.39x38 TM7 hydrophobic
CHEMBL404594 I387 7.39x38 TM7 Van der Waals
CHEMBL404594 Y391 7.43x42 TM7 Van der Waals

Ligands

CHEMBL404594

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Residue Diagrams

S N G F I G V V F I I S Y L T P I M V F 1 L N L A L A D L C F L L T L P L W A V Y 2 C T L L F V S A Y L N F S V S A S A I K 3 A K V T C I I I W L L A G L A S L P A 4 Y S T L I I L F P F L F G L I N K T L G L 5 M A I V L F F F F S W I P H Q I F T F L 6 L P N L C N N F Y A I C I T I P M A T 7
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ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
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Residue Table


GPCRdb(A)
GPCRdb(A)
AT1 receptor
TM2
2x60 2.60x60 W84
2x63 2.63x63 Y87
TM3
3x32 3.32x32 V108
3x36 3.36x36 L112
TM4
4x65 4.64x65 R167
ECL2
45x50 45.50x50 C180
45x51 45.51x51 A181
45x52 45.52x52 F182
TM5
5x43 5.42x43 K199
TM6
6x51 6.51x51 H256
6x58 6.58x58 D263
TM7
7x31 7.32x31 D281
7x34 7.35x34 M284
7x35 7.36x35 P285
7x38 7.39x38 I288
7x42 7.43x42 Y292