Structure information

EP3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6AK3

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

B

REFERENCE

10.1038/S41589-018-0171-8

PUBLICATION DATE

Dec. 5, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PGE<sub>2</sub> M58 1.42x42 TM1 hydrophobic
PGE<sub>2</sub> V110 2.61x61 TM2 hydrophobic
PGE<sub>2</sub> Y114 2.65x65 TM2 Van der Waals
PGE<sub>2</sub> Y114 2.65x65 TM2 polar (hydrogen bond)
PGE<sub>2</sub> M137 3.32x32 TM3 hydrophobic
PGE<sub>2</sub> M137 3.32x32 TM3 Van der Waals
PGE<sub>2</sub> T206 ECL2 Van der Waals
PGE<sub>2</sub> T206 ECL2 polar (hydrogen bond)
PGE<sub>2</sub> W207 ECL2 hydrophobic
PGE<sub>2</sub> W207 ECL2 Van der Waals
PGE<sub>2</sub> F209 45.51x51 ECL2 Van der Waals
PGE<sub>2</sub> W295 6.48x48 TM6 hydrophobic
PGE<sub>2</sub> L329 7.36x35 TM7 hydrophobic
PGE<sub>2</sub> L329 7.36x35 TM7 Van der Waals
PGE<sub>2</sub> V332 7.39x38 TM7 hydrophobic
PGE<sub>2</sub> V332 7.39x38 TM7 Van der Waals
PGE<sub>2</sub> R333 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGE<sub>2</sub> S336 7.43x42 TM7 Van der Waals
PGE<sub>2</sub> Q339 7.46x46 TM7 Van der Waals

Ligands

PGE<sub>2</sub>

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Residue Diagrams

A N G V F G T L L M T I P F A V 1 G W L A L T D L V G Q L L T T P V V I V 2 A S A I F L S S L G F V T M T L G F F T 3 T R A V L L G V W L A V L A F A L L P V 4 N C S F T V T L A L L G L F A F A S A F 5 M G I M C V L S V C W S P L L I M M L K 6 W P D L I Q N L S A L R V A I L F F N 7
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ICL1 R R E S K R ICL1ECL1 Q R W E H I D P S ECL1ICL2 P H W Y A S H M ICL2ECL2 V G Q Y T V Q W P G T W C F I S T G R G G N G T S S S H N ECL2ICL3 T A S Q ICL3ECL3 V E H C K ECL3N-term M K E T R G Y G G D A P F C T R L N H S Y T G M W A P E R S A E A R G N L T R P P G S G E D C G S V S N-termC-term S S T S L P C Q C S S T L M W S D H L E R C-term V A F P I T M L L T G F V G N A L A M L L V S R S Y R K K S F L L C I G W L A L T D L V G Q L L T T P V V I V V Y L S K G R L C T F F G L T M T V F G L S S L F I A S A M A V E R A L A I R A K T R A T R A V L L G V W L A V L A F A L L P V L G W G N L F F A S A F A F L G L L A L T V T F S C N L A T I K A L V S R C R A K A S S A Q W G R I T T E T A I Q L M G I M C V L S V C W S P L L I M M L K M I F N Q T S T H T E K Q K E C N F F L I A V R L A S L N Q I L D P W V Y L L L R K I F C Q T N N L L R K I R Y H Y A S
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP3 receptor
TM1
1x42 1.42x42 M58
TM2
2x61 2.61x61 V110
2x65 2.65x65 Y114
TM3
3x32 3.32x32 M137
ECL2
45x51 45.51x51 F209
TM6
6x48 6.48x48 W295
TM7
7x35 7.36x35 L329
7x38 7.39x38 V332
7x39 7.40x39 R333
7x42 7.43x42 S336
7x46 7.46x46 Q339