Structure information

PAF receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5ZKP

SPECIES

Homo sapiens

RESOLUTION

2.810

PREFERRED CHAIN

A

REFERENCE

10.1038/S41594-018-0068-Y

PUBLICATION DATE

June 20, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Foropafant W73 2.60x60 TM2 aromatic (face-to-face)
Foropafant Y77 2.64x64 TM2 polar (hydrogen bond)
Foropafant F97 3.32x32 TM3 aromatic (face-to-edge)
Foropafant F98 3.33x33 TM3 aromatic (edge-to-face)
Foropafant F174 45.51x51 ECL2 hydrophobic
Foropafant I191 5.43x43 TM5 hydrophobic
Foropafant L279 7.39x38 TM7 hydrophobic

Ligands

Foropafant

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Residue Diagrams

G N A I V G L V F I I S Y V I P F L T Y 1 V N L T M A D M L F L I T L P L W I V Y 2 V G L F A V S C Y T N I F F L C G A V N 3 G I S L S L V I W V A I V G A A S Y F L 4 N C F L I I L F V L F F S F V I F I H I 5 V C T V L A V F I I C F V P H H V V Q L P 6 V P D L V C N T S L L C L T V Q H A D 7
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ICL1 P C K K ICL1ECL1 G N W I L ECL1ICL2 P I K T A Q A N ICL2ECL2 D S T N T V P D S A G S G N V T R C F E H Y E K G ECL2ICL3 P V Q Q ICL3ECL3 F Q ECL3N-term M E P H D S S H M N-termC-term S R K C S R A T T D T V T E V V V P F N Q I P G N S L K N C-term D S E F R Y T L F P I V Y S I I F V L G V I A N G Y V L W V F A R L Y F N E I K I F M V N L T M A D M L F L I T L P L W I V Y Y Q N Q P K F L C N V A G C L F F I N T Y C S V A F L G V I T Y N R F Q A V T R T R K R G I S L S L V I W V A I V G A A S Y F L I L S V P V L I I H I F I V F S F F L V F L I I L F C N L V I I R T L L M Q Q R N A E V K R R A L W M V C T V L A V F I I C F V P H H V V Q L P W T L A E L G D S K F H Q A I N D A H Q V T L C L L S T N C V L D P V I Y C F L T K K F R K K F Y H L T E S M R S
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Residue Table


GPCRdb(A)
GPCRdb(A)
PAF receptor
TM2
2x60 2.60x60 W73
2x64 2.64x64 Y77
TM3
3x32 3.32x32 F97
3x33 3.33x33 F98
ECL2
45x51 45.51x51 F174
TM5
5x43 5.43x43 I191
TM7
7x38 7.39x38 L279