Structure information

M2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5ZKB

SPECIES

Homo sapiens

RESOLUTION

2.950

PREFERRED CHAIN

A

REFERENCE

10.1038/S41589-018-0152-Y

PUBLICATION DATE

Nov. 21, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AF-DX 384 W99 3.28x28 TM3 hydrophobic
AF-DX 384 L100 3.29x29 TM3 hydrophobic
AF-DX 384 D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
AF-DX 384 Y104 3.33x33 TM3 Van der Waals
AF-DX 384 Y104 3.33x33 TM3 polar (hydrogen bond)
AF-DX 384 S107 3.36x36 TM3 polar (hydrogen bond)
AF-DX 384 N108 3.37x37 TM3 Van der Waals
AF-DX 384 V111 3.40x40 TM3 Van der Waals
AF-DX 384 T190 5.42x43 TM5 Van der Waals
AF-DX 384 A191 5.43x44 TM5 Van der Waals
AF-DX 384 A191 5.43x44 TM5 hydrophobic
AF-DX 384 A194 5.46x461 TM5 hydrophobic
AF-DX 384 A194 5.46x461 TM5 Van der Waals
AF-DX 384 F195 5.47x47 TM5 Van der Waals
AF-DX 384 W400 6.48x48 TM6 hydrophobic
AF-DX 384 W400 6.48x48 TM6 Van der Waals
AF-DX 384 Y403 6.51x51 TM6 Van der Waals
AF-DX 384 Y403 6.51x51 TM6 polar (hydrogen bond)
AF-DX 384 N404 6.52x52 TM6 polar (hydrogen bond)
AF-DX 384 N404 6.52x52 TM6 polar (hydrogen bond)
AF-DX 384 Y426 7.39x38 TM7 hydrophobic
AF-DX 384 Y426 7.39x38 TM7 Van der Waals
AF-DX 384 C429 7.42x41 TM7 Van der Waals
AF-DX 384 Y430 7.43x42 TM7 Van der Waals
AF-DX 384 Y430 7.43x42 TM7 hydrophobic

Ligands

AF-DX 384

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Residue Diagrams

I N G I I T V L S L S G A V L V I F V V 1 F S L A C A D L I I G F V S M N L Y T L Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G M M I A A A W V L S F I L W A P A I 4 Y L V T M I I V P L Y F A A I A T G F T V 5 L A I L L A F I I T W A P Y N V M V L I 6 A P N I T S N I Y C L W Y G I T W V T 7
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ICL1 R H L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P V K R ICL2ECL2 V R T V E D G E C Y I Q F F S ECL2ICL3 P V A N Q D P V S P S L V Q G R I V K P N N N N M P S S D D G L E H N K I Q N G K A P R D P V T E N C V Q G E E K E S S N D S T S V S A V A S N M R D D E I T Q D E N T V S T S L G H S K D E N S K Q T C I R I G T K T P K S D S C T P T N T T V E V V G S S G Q N G D E K Q N I V A R K I V K M T K Q P A K K ICL3ECL3 A P C I ECL3N-term M N N S T N S S N N S L A L T S P Y N-termC-term C H Y K N I G A T R C-term K T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K K D K K E K P P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K H F K K T L L M
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Residue Table


GPCRdb(A)
GPCRdb(A)
M2 receptor
TM3
3x28 3.28x28 W99
3x29 3.29x29 L100
3x32 3.32x32 D103
3x33 3.33x33 Y104
3x36 3.36x36 S107
3x37 3.37x37 N108
3x40 3.40x40 V111
TM5
5x43 5.42x43 T190
5x44 5.43x44 A191
5x461 5.46x461 A194
5x47 5.47x47 F195
TM6
6x48 6.48x48 W400
6x51 6.51x51 Y403
6x52 6.52x52 N404
TM7
7x38 7.39x38 Y426
7x41 7.42x41 C429
7x42 7.43x42 Y430