Structure information

CB1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5XRA

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE23272

PUBLICATION DATE

July 12, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AM11542 F170 2.57x57 TM2 aromatic (edge-to-face)
AM11542 F174 2.61x61 TM2 hydrophobic
AM11542 F177 2.64x64 TM2 hydrophobic
AM11542 F189 3.25x25 TM3 hydrophobic
AM11542 L193 3.29x29 TM3 hydrophobic
AM11542 V196 3.32x32 TM3 hydrophobic
AM11542 F268 ECL2 aromatic (edge-to-face)
AM11542 P269 ECL2 hydrophobic
AM11542 W279 5.43x43 TM5 hydrophobic
AM11542 L359 6.51x51 TM6 hydrophobic
AM11542 M363 6.55x55 TM6 hydrophobic
AM11542 F379 7.35x34 TM7 hydrophobic
AM11542 S383 7.39x38 TM7 Van der Waals
AM11542 S383 7.39x38 TM7 polar (hydrogen bond)

Ligands

AM11542

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Residue Diagrams

L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7
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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x57 2.57x57 F170
2x61 2.61x61 F174
2x64 2.64x64 F177
TM3
3x25 3.25x25 F189
3x29 3.29x29 L193
3x32 3.32x32 V196
TM5
5x43 5.43x43 W279
TM6
6x51 6.51x51 L359
6x55 6.55x55 M363
TM7
7x34 7.35x34 F379
7x38 7.39x38 S383