Structure information

glucagon receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

5XEZ

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

B

REFERENCE

10.1038/NATURE22363

PUBLICATION DATE

May 24, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
NNC0640 R346 6.37x37 TM6 polar (hydrogen bond with backbone)
NNC0640 R346 6.37x37 TM6 polar (hydrogen bond with backbone)
NNC0640 S350 6.41x41 TM6 polar (hydrogen bond)
NNC0640 S350 6.41x41 TM6 polar (charge-assisted hydrogen bond)
NNC0640 T353 6.44x44 TM6 polar (hydrogen bond)
NNC0640 L357 6.48x48 TM6 hydrophobic
NNC0640 L399 7.56x56 TM7 polar (hydrogen bond with backbone)
NNC0640 L403 7.60x60 TM7 polar (hydrogen bond with backbone)
NNC0640 N404 8.47x47 H8 polar (hydrogen bond)
NNC0640 N404 8.47x47 H8 polar (hydrogen bond)
NNC0640 N404 8.47x47 H8 polar (hydrogen bond)

Ligands

NNC0640

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Residue Diagrams

L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7
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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
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Residue Table


GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM6
6x32 6.37x37 R346
6x36 6.41x41 S350
6x39 6.44x44 T353
6x43 6.48x48 L357
TM7
7x52 7.56x56 L399
7x56 7.60x60 L403
H8
8x47 8.47x47 N404