Structure information

5-HT2B receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5TVN

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

A

REFERENCE

10.1016/J.CELL.2016.12.033

PUBLICATION DATE

Feb. 1, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Lysergide W131 3.28x28 TM3 hydrophobic
Lysergide D135 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Lysergide V136 3.33x33 TM3 hydrophobic
Lysergide V136 3.33x33 TM3 Van der Waals
Lysergide S139 3.36x36 TM3 Van der Waals
Lysergide L209 45.52x52 ECL2 hydrophobic
Lysergide L209 45.52x52 ECL2 Van der Waals
Lysergide F217 5.38x39 TM5 Van der Waals
Lysergide F217 5.38x39 TM5 hydrophobic
Lysergide M218 5.39x40 TM5 hydrophobic
Lysergide G221 5.42x43 TM5 polar (hydrogen bond with backbone)
Lysergide G221 5.42x43 TM5 Van der Waals
Lysergide S222 5.43x44 TM5 Van der Waals
Lysergide A225 5.46x461 TM5 Van der Waals
Lysergide W337 6.48x48 TM6 Van der Waals
Lysergide F340 6.51x51 TM6 Van der Waals
Lysergide F340 6.51x51 TM6 hydrophobic
Lysergide F341 6.52x52 TM6 aromatic (edge-to-face)
Lysergide F341 6.52x52 TM6 Van der Waals
Lysergide N344 6.55x55 TM6 Van der Waals
Lysergide L362 7.35x34 TM7 Van der Waals
Lysergide E363 7.36x35 TM7 Van der Waals
Lysergide V366 7.39x38 TM7 Van der Waals
Lysergide V366 7.39x38 TM7 hydrophobic

Ligands

Lysergide

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Residue Diagrams

T N G G I T P I I V M L I L L A A W H L K 1 M S L A V A D L L V G F L V M P I A L L T 2 A C L H M I S A T S F L V D L F L W A P 3 A F I K I T V V W L I S I G I A I P V 4 Y T V I M I A L P T F F A A L S G F L M F 5 G I V F F L F L L M W C P F F I T N I T 6 L P N V G S S V Y G I W V F I E L L M 7
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ICL1 K K L Q ICL1ECL1 E A M W P L ECL1ICL2 P I Q A N Q Y N ICL2ECL2 I E T D V D N P N N I T C V L T K E R ECL2ICL3 P Q R L T W L T V S T V F Q R D E T P C S S P E K V A M L D G S R K D K A L P N S G D E T L M R R T S T I G K K S ICL3ECL3 D S C ECL3N-term M A L S Y R V S E L Q S T I P E H I L Q S T F V H V I S S N W S G L Q T E S I P E E M K Q I V E E Q G N N-termC-term T C N Y R A T K S V K T L R K R S S K I Y F R N P M A E N S K F F K K H G I R N G I N P A M Y Q S P M R L R S S T I Q S S S I I L L D T L L L T E N E G D K T E E Q V S Y V C-term K L H W A A L L I L M V I I P T I G G N T L V I L A V S L E Y A T N Y F L M S L A V A D L L V G L F V M P I A L L T I M F P L V L C P A W L F L D V L F S T A S I M H L C A I S V D R Y I A I K K S R A T A F I K I T V V W L I S I G I A I P V P I K G F G D F M L F G S L A A F F T P L A I M I V T Y F L T I H A L Q K K A Y L V K N K P V Q T I S N E Q R A S K V L G I V F F L F L L M W C P F F I T N I T L V L C N Q T T L Q M L L E I F V W I G Y V S S G V N P L V Y T L F N K T F G R F R D A Y I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2B receptor
TM3
3x28 3.28x28 W131
3x32 3.32x32 D135
3x33 3.33x33 V136
3x36 3.36x36 S139
ECL2
45x52 45.52x52 L209
TM5
5x39 5.38x39 F217
5x40 5.39x40 M218
5x43 5.42x43 G221
5x44 5.43x44 S222
5x461 5.46x461 A225
TM6
6x48 6.48x48 W337
6x51 6.51x51 F340
6x52 6.52x52 F341
6x55 6.55x55 N344
TM7
7x34 7.35x34 L362
7x35 7.36x35 E363
7x38 7.39x38 V366